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4. Commissioning and early experiments of the PHELIX facility

Author

Bagnoud, V., Aurand, B., Blazevic, A., Borneis, S., Bruske, C., Ecker, B., Eisenbarth, U., Fils, J., Frank, A., Gaul, E., Goette, S., Haefner, C., Hahn, T., Harres, K., Heuck, H.-M., Hochhaus, D., Hoffmann, D. H., Javorková, D., Kluge, H.-J., Kuehl, T., Kunzer, S., Kreutz, M., Merz-Mantwill, T., Neumayer, P., Onkels, E., Reemts, D., Rosmej, O., Roth, M., Stoehlker, T., Tauschwitz, A., Zielbauer, B., Zimmer, D., and Witte, K.

Subjects
Physics, Physics, general, Engineering, general, Optics, Optoelectronics, Plasmonics and Optical Devices, Quantum Optics, Laser Technology, Photonics, Physical Chemistry
Abstract

At the Helmholtz center GSI, PHELIX (Petawatt High Energy Laser for heavy Ion eXperiments) has been commissioned for operation in stand-alone mode and, in combination with ions accelerated up to an energy of 13 MeV/u by the heavy ion accelerator UNILAC. The combination of PHELIX with the heavy-ion beams available at GSI enables a large variety of unique experiments. Novel research opportunities are spanning from the study of ion–matter interaction, through challenging new experiments in atomic physics, nuclear physics, and astrophysics, into the field of relativistic plasma physics.

Published
2010

5. Compression Therapy in Acute Deep Venous Thrombosis of the Lower Limb and for the Prevention of Post-Thrombotic Syndrome: A Review Based on a Structured Literature Search.

Author

Thieme, Dorothea, Linnemann, B., Mhlberg, K., Noppeney, T., Kreutz, M., and Thieme, M.

Abstract

Background: After an acute deep venous thrombosis (DVT) of the lower limb, 20% to 63% of patients develop post-thrombotic syndrome (PTS). In this review, we address the efficacy of compression therapy in the treatment of acute DVT of the lower limb, and for the prevention of PTS. Methods: 12 randomized controlled trials (RCTs) and one meta-analysis, with a total of 3751 patients, were identified in a structured literature search. Results: Two RCTs showed that adding compression therapy to drug treatment in the first 9 days of the acute phase of lower limb DVT led to more rapid pain relief (p<0.050) and less swelling (remaining difference in circumference, 1 cm versus 3 cm, p<0.050). As for the prevention of PTS, four RCTs showed a short-term benefit or no benefit of compression therapy. In three further RCTs, medical compression stockings (MCS) brought about a 16% to 27% absolute reduction of the frequency and severity of PTS (47% vs. 20 %, p<0.001; 40% vs. 21% (95% confidence intervals [29.9; 50.1] and [12.7; 29.5], respectively; and 58% vs. 42%, relative risk [RR] 0.73 [0,55; 0.96]). The benefit of MCS was also confirmed in a recent meta-analysis (RR 0.66 [0.44; 0.99], I2 = 88%). Thigh-length MCS were not superior to knee-length MCS for the prevention of PTS (33% vs. 36%, hazard ratio [HR] 0.93 [0.62; 1.41]). Individual, symptom-oriented tailoring of the duration of treatment was not inferior to a fixed treatment duration of 24 months (29% vs. 28%; odds ratio [OR] 1.06 [0.78;1.44]). Conclusion: Compression therapy relieves symptoms in acute DVT and lessens the frequency and severity of PTS. It is therefore recommended as standard treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity

Author

Roig Adam, A., Martínez-López, J., van der Spek, S., Achsel, T., Andres-Alonso, M., Bagni, C., Bayés, À., Biederer, T., Brose, N., Chua, J., Coba, M., Cornelisse, L., de Juan-Sanz, J., Goldschmidt, H., Gundelfinger, E., Huganir, R., Imig, C., Jahn, R., https://orcid.org/0000-0003-1542-3498, Jung, H., Kaeser, P., Kim, E., Koopmans, F., Kreutz, M., Lipstein, N., MacGillavry, H., McPherson, P., O’Connor, V., Pielot, R., Ryan, T., Sala, C., Sheng, M., Smalla, K., Thomas, P., Toonen, R., van Weering, J., Verpelli, C., Sullivan, P., Smit, A., Verhage, M., and Hjerling-Leffler, J.

Abstract

Synapse diversity has been described from different perspectives, ranging from the specific neurotransmitters released, to their diverse biophysical properties and proteome profiles. However, synapse diversity at the transcriptional level has not been systematically identified across all synapse populations in the brain. To quantify and identify specific synaptic features of neuronal cell types we combined the SynGO (Synaptic Gene Ontology) database with single-cell RNA sequencing data of the mouse neocortex. We show that cell types can be discriminated by synaptic genes alone with the same power as all genes. The cell type discriminatory power is not equally distributed across synaptic genes as we could identify functional categories and synaptic compartments with greater cell type specific expression. Synaptic genes, and specific SynGO categories, belonged to three different types of gene modules: gradient expression over all cell types, gradient expression in selected cell types and cell class- or type-specific profiles. This data provides a deeper understanding of synapse diversity in the neocortex and identifies potential markers to selectively identify synapses from specific neuronal populations.

Published
2023

8. Versatile High-Energy and Short-Pulse Operation of PHELIX

Author

Kuehl, T., Bagnoud, V., Bruske, C., Borneis, S., Ecker, B., Eisenbarth, U., Fils, J., Goette, S., Hahn, T., Hochhaus, D., Javorkova, D., Knobloch, F., Kreutz, M., Kunzer, S., Merz-Mantwill, T., Onkels, E., Reemts, D., Tauschwitz, A., Witte, K., Zielbauer, B., Zimmer, D., Lewis, Ciaran L. S., editor, and Riley, Dave, editor

Published
2009
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10. P02.09 Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells

Author

Schmidl, C, primary, Riegel, D, additional, Romero-Fernández, E, additional, Simon, M, additional, Adenugba, A, additional, Singer, K, additional, Mayr, R, additional, Weber, F, additional, Imbusch, CD, additional, Kreutz, M, additional, Brors, B, additional, Ugele, I, additional, Werner, JM, additional, and Siska, PJ, additional

Published
2022
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31. Expression of CD68 in Non-Myeloid Cell Types

Author

Gottfried, E., Kunz-Schughart, L. A., Weber, A., Rehli, M., Peuker, A., Müller, A., Kastenberger, M., Brockhoff, G., Andreesen, R., and Kreutz, M.

Published
2008

40. Diagnostic and neural analysis of skin cancer (DANAOS). A multicentre study for collection and computer-aided analysis of data from pigmented skin lesions using digital dermoscopy

Author

HOFFMANN, K., GAMBICHLER, T., RICK, A., KREUTZ, M., ANSCHUETZ, M., GRÜNENDICK, T., ORLIKOV, A., GEHLEN, S., PEROTTI, R., ANDREASSI, L., BISHOP, J. NEWTON, CÉSARINI, J-P., FISCHER, T., FROSCH, P. J., LINDSKOV, R., MACKIE, R., NASHAN, D., SOMMER, A., NEUMANN, M., ORTONNE, J. P., BAHADORAN, P., PENAS, P. F., ZORAS, U., and ALTMEYER, P.

Published
2003

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