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1,043 results on '"Krieg, Sandro M"'

7. Multi-class glioma segmentation on real-world data with missing MRI sequences: comparison of three deep learning algorithms

Author

Pemberton, Hugh G., Wu, Jiaming, Kommers, Ivar, Müller, Domenique M. J., Hu, Yipeng, Goodkin, Olivia, Vos, Sjoerd B., Bisdas, Sotirios, Robe, Pierre A., Ardon, Hilko, Bello, Lorenzo, Rossi, Marco, Sciortino, Tommaso, Nibali, Marco Conti, Berger, Mitchel S., Hervey-Jumper, Shawn L., Bouwknegt, Wim, Van den Brink, Wimar A., Furtner, Julia, Han, Seunggu J., Idema, Albert J. S., Kiesel, Barbara, Widhalm, Georg, Kloet, Alfred, Wagemakers, Michiel, Zwinderman, Aeilko H., Krieg, Sandro M., Mandonnet, Emmanuel, Prados, Ferran, de Witt Hamer, Philip, Barkhof, Frederik, and Eijgelaar, Roelant S.

Published
2023
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22. Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee

Author

Vucic, Steve, Stanley Chen, Kai-Hsiang, Kiernan, Matthew C., Hallett, Mark, Benninger, David.H., Di Lazzaro, Vincenzo, Rossini, Paolo M, Benussi, Alberto, Berardelli, Alfredo, Currà, Antonio, Krieg, Sandro M, Lefaucheur, Jean-Pascal, Long Lo, Yew, Macdonell, Richard A, Massimini, Marcello, Rosanova, Mario, Picht, Thomas, Stinear, Cathy M, Paulus, Walter, Ugawa, Yoshikazu, Ziemann, Ulf, and Chen, Robert

Published
2023
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23. DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment

Author

Bernhardt, Denise, König, Laila, Grosu, Anca-L., Rieken, Stefan, Krieg, Sandro M., Wick, Wolfgang, Wiestler, Benedikt, Schmidt-Graf, Friederike, Sahm, Felix, Gempt, Jens, Meyer, Bernhard, Krause, Bernd J., Petersen, Cordula, Fietkau, Rainer, Thomas, Michael, Giordano, Frank, Wittig-Sauerwein, Andrea, Debus, Jürgen, Tabatabai, Ghazaleh, Hau, Peter, Steinbach, Joachim, and Combs, Stephanie E.

Published
2022
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24. DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis

Author

Bernhardt, Denise, König, Laila, Grosu, Anca, Wiestler, Benedikt, Rieken, Stefan, Wick, Wolfgang, Gempt, Jens, Krieg, Sandro M., Schmidt-Graf, Friederike, Sahm, Felix, Meyer, Bernhard, Krause, Bernd J., Petersen, Cordula, Fietkau, Rainer, Thomas, Michael, Giordano, Frank, Wittig-Sauerwein, Andrea, Debus, Jürgen, Tabatabai, Ghazaleh, Hau, Peter, Steinbach, Joachim, and Combs, Stephanie E.

Published
2022
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26. Motor Cortical Network Plasticity in Patients With Recurrent Brain Tumors

Author

Bulubas, Lucia, Sardesh, Nina, Traut, Tavish, Findlay, Anne, Mizuiri, Danielle, Honma, Susanne M, Krieg, Sandro M, Berger, Mitchel S, Nagarajan, Srikantan S, and Tarapore, Phiroz E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Neurosciences, Minority Health, Brain Cancer, Brain Disorders, Biomedical Imaging, Clinical Research, Rare Diseases, Bioengineering, Neurological, brain tumor, magnetoencephalography, motor cortex, neurological surgery, preoperative motor mapping, plasticity, recurrent tumors, Psychology, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

Objective: The adult brain's potential for plastic reorganization is an important mechanism for the preservation and restoration of function in patients with primary glial neoplasm. Patients with recurrent brain tumors requiring multiple interventions over time present an opportunity to examine brain reorganization. Magnetoencephalography (MEG) is a noninvasive imaging modality that can be used for motor cortical network mapping which, when performed at regular intervals, offers insight into this process of reorganization. Utilizing MEG-based motor mapping, we sought to characterize the reorganization of motor cortical networks over time in a cohort of 78 patients with recurrent glioma. Methods: MEG-based motor cortical maps were obtained by measuring event-related desynchronization (ERD) in ß-band frequency during unilateral index finger flexion. Each patient presented at our Department at least on two occasions for tumor resection due to tumor recurrence, and MEG-based motor mapping was performed as part of preoperative assessment before each surgical resection. Whole-brain activation patterns from first to second MEG scan (obtained before first and second surgery) were compared. Additionally, we calculated distances of activation peaks, which represent the location of the primary motor cortex (MC), to determine the magnitude of movement in motor eloquent areas between the first and second MEG scan. We also explored which demographic, anatomic, and pathological factors influence these shifts. Results: The whole-brain activation motor maps showed a subtle movement of the primary MC from first to second timepoint, as was confirmed by the determination of motor activation peaks. The shift of ipsilesional MC was directly correlated with a frontal-parietal tumor location (p < 0.001), presence of motor deficits (p = 0.021), and with a longer period between MEG scans (p = 0.048). Also, a disengagement of wide areas in the contralesional (ipsilateral to finger movement) hemisphere at the second time point was observed. Conclusions: MEG imaging is a sensitive method for depicting the plasticity of the motor cortical network. Although the location of the primary MC undergoes only subtle changes, appreciable shifts can occur in the setting of a stronger and longer impairment of the tumor on the MC. The ipsilateral hemisphere may serve as a reservoir for functional recovery.

Published
2020

42. Liquid Biopsy in Whole Blood for Identification of Gene Expression Patterns (mRNA and miRNA) Associated with Recurrence of Glioblastoma WHO CNS Grade 4.

Author

Muhtadi, Razan, Bernhardt, Denise, Multhoff, Gabriele, Hönikl, Lisa, Combs, Stephanie E., Krieg, Sandro M., Gempt, Jens, Meyer, Bernhard, Barsegian, Vahé, Lindemann, Monika, Kasper, Mandy, Stewart, Samantha, Port, Matthias, Abend, Michael, Diehl, Christian D., and Ostheim, Patrick

Subjects
GLIOMAS, CANCER relapse, STATISTICAL significance, RESEARCH funding, MICRORNA, BODY fluid examination, DESCRIPTIVE statistics, GENE expression, LONGITUDINAL method, MESSENGER RNA, CENTRAL nervous system tumors, EARLY diagnosis, DATA analysis software, BIOMARKERS
Abstract

Simple Summary: This research investigates the identification of tumor-specific serological biomarkers for the early diagnosis of glioblastoma multiforme (GBM) recurrence using peripheral whole blood samples in a minimally invasive approach known as "liquid biopsy". Our results indicate that gene expression analysis can detect changes in transcriptional (mRNAs) and post-transcriptional (small RNAs) levels after surgery and upon tumor recurrence. This prospective study aims to develop a diagnostic tool complementary to MRI modalities in the clinical follow-up, helping to track tumor progression/recurrence and to make clinical decisions. GBM WHO CNS Grade 4 represents a major challenge for oncology due to its aggressive behavior. Conventional imaging has restrictions in detecting tumor recurrence. This prospective study aims to identify gene-based biomarkers in whole blood instead of isolating exosomes for the early detection of tumor recurrence. Blood samples (n = 33) were collected from seven GBM patients at time points before and after surgery as well as upon tumor recurrence. Four tumor tissue samples were assessed in parallel. Next-generation sequencing (NGS), including mRNA-seq and small RNA-seq, was used to analyze gene expression profiles in blood samples and tumor tissues. A novel filtering pipeline was invented to narrow down potential candidate genes. In total, between 6–93 mRNA and 1–19 small RNA candidates could be identified among the seven patients. The overlap of genes between the patients was minimal, indicating significant inter-individual variance among GBM patients. In summary, this prospective study supports the applicability of gene expression measurements in whole blood for the detection of tumor recurrence. It might provide an alternative to the challenging workflow of liquid biopsy after laborious exosome isolation from whole blood. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Can a Hand-Held Navigation Device Reduce Cognitive Load? A User-Centered Approach Evaluated by 18 Surgeons

Author

Brendle, Caroline, Schütz, Laura, Esteban, Javier, Krieg, Sandro M., Eck, Ulrich, Navab, Nassir, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Martel, Anne L., editor, Abolmaesumi, Purang, editor, Stoyanov, Danail, editor, Mateus, Diana, editor, Zuluaga, Maria A., editor, Zhou, S. Kevin, editor, Racoceanu, Daniel, editor, and Joskowicz, Leo, editor

Published
2020
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50. Proposed definition of competencies for surgical neuro-oncology training

Author

Kamp, Marcel A., Malzkorn, Bastian, von Sass, Christiane, DiMeco, Francesco, Hadjipanayis, Constantinos G., Senft, Christian, Rapp, Marion, Gepfner-Tuma, Irina, Fountas, Konstantinos, Krieg, Sandro M., Neukirchen, Martin, Florian, Ioan Ștefan, Schnell, Oliver, Mijderwijk, Hendrik-Jan, Perin, Alessandro, Baumgarten, Peter, van Lieshout, Jasper H., Thon, Niklas, Renovanz, Miriam, Kahlert, Ulf, Spoor, Jochem K. H., Hänggi, Daniel, McLean, Aaron Lawson, Mäurer, Matthias, Sarrubbo, Silvio, Freyschlag, Christian F., Schmidt, Nils O., Vergani, Francesco, Jungk, Christine, Stein, Marco, Forster, Marie-Therese, Weinberg, Jeffrey S., Sinclair, John, Belykh, Evgenii, Bello, Lorenzo, Mandonnet, Emmanuel, Moiyadi, Aliasgar, and Sabel, Michael

Published
2021
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