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Aim: The present study compared the safety, efficacy, and tolerability of the new fixed-dose combination (FDC) of telmisartan 40 mg + bisoprolol 5 mg (TBP) tablets with the existing comparator FDC telmisartan 40 mg + metoprolol succinate ER 50 mg (TMS) tablets in patients with stage 1 and stage 2 hypertension. Methodology: The multicentric, double-blind, parallel-group, comparative, prospective, phase-III clinical study involved 264 subjects with stage 1 and stage 2 hypertension from 10 centres across India. The selected subjects were randomized into two groups: group A received the TMS and group B received the new FDC TBP. The primary endpoint was the mean change in seated systolic blood pressure (SeSBP) and seated diastolic blood pressure (SeDBP) from baseline to week 12 in both the control and study arms. The secondary endpoint was achieving the target of SeSBP

Recent research has explored the utilization of sugarcane bagasse, a bio-industrial waste, to fabricate energy storage devices due to ecofriendly nature, low cost with industrial scale production. In this investigation, cobalt oxide hollow spheres (Co3O4 HSs) were synthesized from waste sugarcane bagasse extract with the carbon spheres (CSs) act as template. The main component of sucrose (C12H22O11) linked with cellulose fibers and other oxygenic functional groups were used to prepare CSs. Previously, a metal precursor (Co(NO3)2.6H2O) was mixed with sugarcane bagasse extract and subjected to a hydrothermal process, resulting in uniform-sized metal CSs. The uniform sized Co3O4 HSs were formed by calcined metal CSs. The calcination temperature plays a crucial role to eliminating implanted carbon material on inter surface area of the metal oxide, shaping the Co3O4 HSs. Structural, vibrational, morphology and elemental analyses were confirmed by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), respectively. Electrochemical tests show improved ion transport and low resistance, leading to high capacitance in asymmetric supercapacitor (ASC) devices. Subsequently, for asymmetric supercapacitor (ASC) devices, using with Co3O4 HSs has function of cathode and activated carbon (AC) as anode, the devices demonstrated impressive results of 33.1 Fg− 1 at 1 Ag− 1, 86.8% retention after 4,000 cycles, as well as the energy density and power density of 5.9 W h kg− 1 at 1500 W kg− 1. The Co3O4 HSs||AC device exhibits promising energy storage properties for future applications. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study was to validate the potential of teneligliptin in managing type 2 diabetes mellitus (T2DM) with renal impairment and to evaluate its effect on renal parameters in Indian subjects. Patients and Methods: The prospective observational study included 86 subjects aged >40 years with suboptimal control of T2DM (HbA1c >7.5). The demographic details of the selected subjects were recorded. The patients were continued on existing oral hypoglycemic agents (OHAs) and antihypertensives. The following clinical and anthropometric parameters were measured at baseline, 4 months, 8 months, and 12 months during the treatment using 20 mg of teneligliptin per day: HbA1c, eGFRs, UACR, FBG, and PPBG levels. Comparisons of anthropometric and laboratory parameters were carried out using analysis of variance (ANOVA) and t test for normal data, Kruskal–Wallis for nonnormal data, and chi-square test for counts data. Results: The mean age of the subjects was 54.28 ± 6.8 years and the male-to-female ratio noted was 1:0.65. The mean values of FBG (mg/dL ± SD) at 4, 8, and 12 months were found to be statistically significant (P < 0.001, 117.12 ± 30.51, 109.69 ± 43.66, and 113.16 ± 56.93, respectively). t test carried out for PPBG indicated that the levels at respective intervals were significantly reduced as opposed to baseline (P < 0.05). The difference in HbA1c (%) across baseline, 4, 8, and 12 months was found to be statistically significant (P < 0.001) and the mean levels noted were 8.09 ± 2.26, 7.57 ± 1.84, 6.95 ± 1.80, and 6.46 ± 1.81, respectively. The difference in UACR across different intervals was found to be statistically significant (P < 0.001) and the corresponding mean UACRs (mg/g ± SD) noted were 417.21 ± 182.87, 291.82 ± 98.30, 296.84 ± 109.48 and 284.18 ± 103.26. Conclusion: Teneligliptin monotherapy is well tolerated with a persistent reduction in HbA1C and significant improvement in renal function.

High edge energy storage with large life-span stable materials have become the most significant and major requirement in near future. Bismuth sulfide (Bi2S3) nanoparticles (NPs) was effectively synthesized by utilizing bismuth diethyldithiocarbamate (Bi[DTC]3) complex as single-source antecedent. The synthesized Bi2S3 NPs were affirmed by structural, morphological and thermal analysis with various analytical studies. The electrochemical performance of Bi2S3 NPs reveals that, exhibit redox behavior from cyclic voltammetry analysis, the charge–discharge analysis was examined by the galvanostatic chronopotentiometry. Bi2S3 NPs exhibit excellent supercapacitor behavior with value of the specific capacitance 470 Fg−1 at current density 0.5 Ag−1 and the retentivity of 79% after 1000 cycles. The Bi2S3 NPs were further utilized as photocatalytic discoloration of Congo Red (CR) dye in aqueous medium under UV light irradiation. Which shows, excellent catalytic behaviour, up to 98% of CR dye degrade within 150 min and it is exhibit good catalytic stability and reusability. [ABSTRACT FROM AUTHOR]