3,935 results on '"Krishnamoorthy, P."'
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2. Nutritional Evaluation of Hydroponic Maize (Zea mays) Grain Sprouts as a Newer Green Feed Resource in Lambs
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Chethan, K.P., Gowda, N.K.S., Prabhu, T.M., Krishnamoorthy, P., Dey, Debaprio Kumar, Giridhar, K., and Anandan, S.
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- 2022
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3. Real-Time Device Reach Forecasting Using HLL and MinHash Data Sketches
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Muniyappa, Chandrashekar, Willets, Kendall, and Krishnamoorthy, Sriraman
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Computer Science - Databases ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,60G25 ,I.5.3 - Abstract
Predicting the right number of TVs (Device Reach) in real-time based on a user-specified targeting attributes is imperative for running multi-million dollar ADs business. The traditional approach of SQL queries to join billions of records across multiple targeting dimensions is extremely slow. As a workaround, many applications will have an offline process to crunch these numbers and present the results after many hours. In our case, the solution was an offline process taking 24 hours to onboard a customer resulting in a potential loss of business. To solve this problem, we have built a new real-time prediction system using MinHash and HyperLogLog (HLL) data sketches to compute the device reach at runtime when a user makes a request. However, existing MinHash implementations do not solve the complex problem of multilevel aggregation and intersection. This work will show how we have solved this problem, in addition, we have improved MinHash algorithm to run 4 times faster using Single Instruction Multiple Data (SIMD) vectorized operations for high speed and accuracy with constant space to process billions of records. Finally, by experiments, we prove that the results are as accurate as traditional offline prediction system with an acceptable error rate of 5%.
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- 2025
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4. On variants of Chowla's conjecture
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Krishnamoorthy, Krishnarjun
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Mathematics - Number Theory ,Mathematics - Combinatorics ,Primary : 11N37, 11P32, Secondary : 11N35, 11T06 - Abstract
Let $P$ be a (possibly empty) subset of primes, and let $H = \{h_1, \ldots, h_d\}$ be a subset of $\{0,1,2,\ldots\}$. We consider the limit \[ \lim_{x\to\infty}\frac{1}{x} \sum_{n\leqslant x} \lambda_P(n+h_1)\ldots\lambda_P(n+h_d) \] where $\lambda_P$ denotes the completely multiplicative function taking the value $-1$ at primes $p$ in $P$ and $1$ at every other prime. When $P$ is a small set, we evaluate the limit exactly, in particular showing that it exists. For arbitrary non-empty $P$, we show that limit (assuming that it exists) does not equal $\{\pm 1\}$, extending a result of Matom\"aki and Radziwi\l\l. We also determine the corresponding ``spectrum''., Comment: 14 Pages, Comments and suggestions welcome
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- 2025
5. DNN-Powered MLOps Pipeline Optimization for Large Language Models: A Framework for Automated Deployment and Resource Management
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Krishnamoorthy, Mahesh Vaijainthymala, Palavesam, Kuppusamy Vellamadam, Arcot, Siva Venkatesh, and Kuppuswami, Rajarajeswari Chinniah
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Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Machine Learning - Abstract
The exponential growth in the size and complexity of Large Language Models (LLMs) has introduced unprecedented challenges in their deployment and operational management. Traditional MLOps approaches often fail to efficiently handle the scale, resource requirements, and dynamic nature of these models. This research presents a novel framework that leverages Deep Neural Networks (DNNs) to optimize MLOps pipelines specifically for LLMs. Our approach introduces an intelligent system that automates deployment decisions, resource allocation, and pipeline optimization while maintaining optimal performance and cost efficiency. Through extensive experimentation across multiple cloud environments and deployment scenarios, we demonstrate significant improvements: 40% enhancement in resource utilization, 35% reduction in deployment latency, and 30% decrease in operational costs compared to traditional MLOps approaches. The framework's ability to adapt to varying workloads and automatically optimize deployment strategies represents a significant advancement in automated MLOps management for large-scale language models. Our framework introduces several novel components including a multi-stream neural architecture for processing heterogeneous operational metrics, an adaptive resource allocation system that continuously learns from deployment patterns, and a sophisticated deployment orchestration mechanism that automatically selects optimal strategies based on model characteristics and environmental conditions. The system demonstrates robust performance across various deployment scenarios, including multi-cloud environments, high-throughput production systems, and cost-sensitive deployments. Through rigorous evaluation using production workloads from multiple organizations, we validate our approach's effectiveness in reducing operational complexity while improving system reliability and cost efficiency., Comment: 22 pages, 15 figures, submitting to a AI Journal
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- 2025
6. A Stable Measure for Conditional Periodicity of Time Series using Persistent Homology
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Krishnamoorthy, Bala and Thompson, Elizabeth P.
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Mathematics - Algebraic Topology ,Mathematics - Statistics Theory ,Statistics - Machine Learning ,62M10, 55N31 - Abstract
Given a pair of time series, we study how the periodicity of one influences the periodicity of the other. There are several known methods to measure the similarity between a pair of time series, such as cross-correlation, coherence, cross-recurrence, and dynamic time warping. But we have yet to find any measures with theoretical stability results. Persistence homology has been utilized to construct a scoring function with theoretical guarantees of stability that quantifies the periodicity of a single univariate time series f1, denoted score(f1). Building on this concept, we propose a conditional periodicity score that quantifies the periodicity of one univariate time series f1 given another f2, denoted score(f1|f2), and derive theoretical stability results for the same. With the use of dimension reduction in mind, we prove a new stability result for score(f1|f2) under principal component analysis (PCA) when we use the projections of the time series embeddings onto their respective first K principal components. We show that the change in our score is bounded by a function of the eigenvalues corresponding to the remaining (unused) N-K principal components and hence is small when the first K principal components capture most of the variation in the time series embeddings. Finally we derive a lower bound on the minimum embedding dimension to use in our pipeline which guarantees that any two such embeddings give scores that are within a given epsilon of each other. We present a procedure for computing conditional periodicity scores and implement it on several pairs of synthetic signals. We experimentally compare our similarity measure to the most-similar statistical measure of cross-recurrence, and show the increased accuracy and stability of our score when predicting and measuring whether or not the periodicities of two time series are similar., Comment: 24 pages, 9 figures
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- 2025
7. Optical Wireless Communications: Enabling the Next Generation Network of Networks
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Krishnamoorthy, Aravindh, Safi, Hossein, Younus, Othman, Kazemi, Hossein, Osahon, Isaac N. O., Liu, Mingqing, Liu, Yi, Babadi, Sina, Ahmad, Rizwana, Ihsan, Asim, Majlesein, Behnaz, Huang, Yifan, Herrnsdorf, Johannes, Rajbhandari, Sujan, McKendry, Jonathan, Tavakkolnia, Iman, Caglayan, Humeyra, Helmers, Henning, Turnbull, Graham, Samuel, Ifor D. W., Dawson, Martin, Schober, Robert, and Haas, Harald
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Electrical Engineering and Systems Science - Signal Processing - Abstract
Optical wireless communication (OWC) is a promising technology anticipated to play a key role in the next-generation network of networks. To this end, this paper details the potential of OWC, as a complementary technology to traditional radio frequency communications, in enhancing networking capabilities beyond conventional terrestrial networks. Several usage scenarios and the current state of development are presented. Furthermore, a summary of existing challenges and opportunities are provided. Emerging technologies aimed at further enhancing future OWC capabilities are introduced. Additionally, value-added OWC-based technologies that leverage the unique properties of light are discussed, including applications such as positioning and gesture recognition. The paper concludes with the reflection that OWC provides unique functionalities that can play a crucial role in building convergent and resilient future network of networks., Comment: This work has been submitted to the IEEE for possible publication. 15pp, 16 figures, and one table
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- 2024
8. On the vanishing of coefficients of $\eta^{26}
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Krishnamoorthy, S. and Dalal, T.
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Mathematics - Number Theory - Abstract
J.-P. Serre, in his paper [1], established a sufficient condition on $n$ for the $n$-th coefficient of the series $\eta^{26}$ to vanish. However, the question that whether this is a necessary condition remained unanswered. In this paper, using the theory of Hecke eigenforms explored by Serre, we prove some partial cases for the converse part., Comment: arXiv admin note: text overlap with arXiv:2006.15511 by other authors
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- 2024
9. On an indivisibility version of Iizuka's conjecture
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R, Muneeswaran, Krishnamoorthy, Srilakshmi, and Bhakta, Subham
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Mathematics - Number Theory - Abstract
We establish the existence of a positive proportion of \( d \in \mathbb{N} \) such that the class numbers of \( \mathbb{Q}(\sqrt{d}), \mathbb{Q}(\sqrt{d+1}), \dots, \mathbb{Q}(\sqrt{d+n}) \) are not divisible by \( 3^k \), where \( n = 3^{k+1} - 5 \) and \( k \in \mathbb{N} \). This provides an indivisibility analog of Iizuka's conjecture. Similarly, for \( d < 0 \) and the same \( n \), a positive proportion of \( d \) ensures that the class numbers of \( \mathbb{Q}(\sqrt{d}), \mathbb{Q}(\sqrt{d+1}), \dots, \mathbb{Q}(\sqrt{d+n}) \) are not divisible by \( 3^{k+1} \). Denoting the square-free natural numbers by \( (d_n) \), we prove the existence of a positive density set of \( i\in\mathbb{N} \) such that the class numbers of \( \mathbb{Q}(\sqrt{d_i}), \mathbb{Q}(\sqrt{d_{i+1}}), \dots, \mathbb{Q}(\sqrt{d_{i+n}}) \) are not divisible by \( 3^k \). Moreover, we study the indivisibility of class numbers by $3$ for imaginary biquadratic fields.
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- 2024
10. Flight Demonstration and Model Validation of a Prototype Variable-Altitude Venus Aerobot
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Izraelevitz, Jacob S., Krishnamoorthy, Siddharth, Goel, Ashish, Turner, Caleb, Aiazzi, Carolina, Pauken, Michael, Carlson, Kevin, Walsh, Gerald, Leake, Carl, Quintana, Carlos, Lim, Christopher, Jain, Abhi, Dorsky, Leonard, Baines, Kevin, Cutts, James, Byrne, Paul K., Lachenmeier, Tim, and Hall, Jeffery L.
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Computer Science - Robotics - Abstract
This paper details a significant milestone towards maturing a buoyant aerial robotic platform, or aerobot, for flight in the Venus clouds. We describe two flights of our subscale altitude-controlled aerobot, fabricated from the materials necessary to survive Venus conditions. During these flights over the Nevada Black Rock desert, the prototype flew at the identical atmospheric densities as 54 to 55 km cloud layer altitudes on Venus. We further describe a first-principle aerobot dynamics model which we validate against the Nevada flight data and subsequently employ to predict the performance of future aerobots on Venus. The aerobot discussed in this paper is under JPL development for an in-situ mission flying multiple circumnavigations of Venus, sampling the chemical and physical properties of the planet's atmosphere and also remotely sensing surface properties., Comment: Preprint submitted to AIAA Journal of Aircraft
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- 2024
11. A Comparative Study of Distributed Feedback Optimizing Control Architectures
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Dirza, Risvan, Varadarajan, Hari Prasad, Aas, Vegard, Skogestad, Sigurd, and Krishnamoorthy, Dinesh
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Mathematics - Optimization and Control ,Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper considers the problem of steady-state real-time optimization (RTO) of interconnected systems with a common constraint that couples several units, for example, a shared resource. Such problems are often studied under the context of distributed optimization, where decisions are made locally in each subsystem, and are coordinated to optimize the overall performance. Here, we use distributed feedback-optimizing control framework, where the local systems and the coordinator problems are converted into feedback control problems. This is a powerful scheme that allows us to design feedback control loops, and estimate parameters locally, as well as provide local fast response, allowing different closed-loop time constants for each local subsystem. This paper provides a comparative study of different distributed feedback optimizing control architectures using two case studies. The first case study considers the problem of demand response in a residential energy hub powered by a common renewable energy source, and compares the different feedback optimizing control approaches using simulations. The second case study experimentally validates and compares the different approaches using a lab-scale experimental rig that emulates a subsea oil production network, where the common resource is the gas lift that must be optimally allocated among the wells. %The pros and cons of the different approaches are discussed., Comment: Accepted to IEEE Transactions on Control Systems Technology
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- 2024
12. Meta-Sealing: A Revolutionizing Integrity Assurance Protocol for Transparent, Tamper-Proof, and Trustworthy AI System
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Krishnamoorthy, Mahesh Vaijainthymala
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Computer Science - Cryptography and Security ,Computer Science - Artificial Intelligence - Abstract
The Artificial intelligence in critical sectors-healthcare, finance, and public safety-has made system integrity paramount for maintaining societal trust. Current verification methods for AI systems lack comprehensive lifecycle assurance, creating significant vulnerabilities in deployment of both powerful and trustworthy AI. This research introduces Meta-Sealing, a cryptographic framework that fundamentally changes integrity verification in AI systems throughout their operational lifetime. Meta-Sealing surpasses traditional integrity protocols through its implementation of cryptographic seal chains, establishing verifiable, immutable records for all system decisions and transformations. The framework combines advanced cryptography with distributed verification, delivering tamper-evident guarantees that achieve both mathematical rigor and computational efficiency. Our implementation addresses urgent regulatory requirements for AI system transparency and auditability. The framework integrates with current AI governance standards, specifically the EU's AI Act and FDA's healthcare AI guidelines, enabling organizations to maintain operational efficiency while meeting compliance requirements. Testing on financial institution data demonstrated Meta-Sealing's capability to reduce audit timeframes by 62% while enhancing stakeholder confidence by 47%. Results can establish a new benchmark for integrity assurance in enterprise AI deployments. This research presents Meta-Sealing not merely as a technical solution, but as a foundational framework ensuring AI system integrity aligns with human values and regulatory requirements. As AI continues to influence critical decisions, provides the necessary bridge between technological advancement and verifiable trust. Meta-Sealing serves as a guardian of trust, ensuring that the AI systems we depend on are as reliable and transparent as they are powerful., Comment: 24 pages, 3 figures and 10 Code blocks, to be presented in the conference
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- 2024
13. Data Obfuscation through Latent Space Projection (LSP) for Privacy-Preserving AI Governance: Case Studies in Medical Diagnosis and Finance Fraud Detection
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Krishnamoorthy, Mahesh Vaijainthymala
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Cryptography and Security ,Computer Science - Computers and Society ,F.2.1 ,E.3 - Abstract
As AI systems increasingly integrate into critical societal sectors, the demand for robust privacy-preserving methods has escalated. This paper introduces Data Obfuscation through Latent Space Projection (LSP), a novel technique aimed at enhancing AI governance and ensuring Responsible AI compliance. LSP uses machine learning to project sensitive data into a latent space, effectively obfuscating it while preserving essential features for model training and inference. Unlike traditional privacy methods like differential privacy or homomorphic encryption, LSP transforms data into an abstract, lower-dimensional form, achieving a delicate balance between data utility and privacy. Leveraging autoencoders and adversarial training, LSP separates sensitive from non-sensitive information, allowing for precise control over privacy-utility trade-offs. We validate LSP's effectiveness through experiments on benchmark datasets and two real-world case studies: healthcare cancer diagnosis and financial fraud analysis. Our results show LSP achieves high performance (98.7% accuracy in image classification) while providing strong privacy (97.3% protection against sensitive attribute inference), outperforming traditional anonymization and privacy-preserving methods. The paper also examines LSP's alignment with global AI governance frameworks, such as GDPR, CCPA, and HIPAA, highlighting its contribution to fairness, transparency, and accountability. By embedding privacy within the machine learning pipeline, LSP offers a promising approach to developing AI systems that respect privacy while delivering valuable insights. We conclude by discussing future research directions, including theoretical privacy guarantees, integration with federated learning, and enhancing latent space interpretability, positioning LSP as a critical tool for ethical AI advancement., Comment: 19 pages, 6 figures, submitted to Conference ICADCML2025
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- 2024
14. Large Language Models for More Efficient Reporting of Hospital Quality Measures.
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Boussina, Aaron, Krishnamoorthy, Rishivardhan, Quintero, Kimberly, Joshi, Shreyansh, Wardi, Gabriel, Pour, Hayden, Hilbert, Nicholas, Malhotra, Atul, Hogarth, Michael, Sitapati, Amy, VanDenBerg, Chad, Singh, Karandeep, Longhurst, Christopher, and Nemati, Shamim
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Hospital quality measures are a vital component of a learning health system, yet they can be costly to report, statistically underpowered, and inconsistent due to poor interrater reliability. Large language models (LLMs) have recently demonstrated impressive performance on health care-related tasks and offer a promising way to provide accurate abstraction of complete charts at scale. To evaluate this approach, we deployed an LLM-based system that ingests Fast Healthcare Interoperability Resources data and outputs a completed Severe Sepsis and Septic Shock Management Bundle (SEP-1) abstraction. We tested the system on a sample of 100 manual SEP-1 abstractions that University of California San Diego Health reported to the Centers for Medicare & Medicaid Services in 2022. The LLM system achieved agreement with manual abstractors on the measure category assignment in 90 of the abstractions (90%; κ=0.82; 95% confidence interval, 0.71 to 0.92). Expert review of the 10 discordant cases identified four that were mistakes introduced by manual abstraction. This pilot study suggests that LLMs using interoperable electronic health record data may perform accurate abstractions for complex quality measures. (Funded by the National Institute of Allergy and Infectious Diseases [1R42AI177108-1] and others.).
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- 2024
15. NiOx/\b{eta}-Ga2O3 Heterojunction Diode Achieving Breakdown Voltage >3 kV with Plasma Etch Field-Termination
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Liu, Yizheng, Roy, Saurav, Peterson, Carl, Bhattacharyya, Arkka, and Krishnamoorthy, Sriram
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Physics - Applied Physics - Abstract
This work reports the fabrication and characterization of a NiOx/\b{eta}-Ga2O3 heterojunction diode (HJD) that uses a metallic nickel (Ni) target to deposit NiOx layers via reactive RF magnetron sputtering and lift-off processing with >3 kV breakdown voltage, record-low reverse current leakage under high reverse bias, and high junction electric fields (>3.34 MV/cm). The heterojunction diodes are fabricated via bilayer NiOx sputtering followed by self-aligned mesa-etching for field-termination on both large (1-mm2) and small area (100-{\mu}m diameter) devices. The HJD exhibits a ~135 A/cm2 forward current density at 5 V with a rectifying ratio of ~1010. The minimum differential specific on-resistance is measured to be 17.26 m{\Omega} cm2. The breakdown voltage on 100-{\mu}m diameter pads was measured to be greater than 3 kV with a noise floor-level reverse leakage current density (10-8~10-6 A/cm2) until 3 kV, accomplishing a parallel-plane junction electric field to be at least 3.34 MV/cm at 3 kV with a power figure of merit (PFOM) >0.52 GW/cm2. Temperature-dependent forward current density-voltage (J-V) measurements are performed from room temperature (25 C) to 200 C which showed a temperature coefficient of resistance ({\alpha}) equaling 1.56, higher than that of \b{eta}-Ga2O3 Schottky barrier diodes (SBDs), indicating potential conductivity degradation within NiOx at elevated temperatures., Comment: 6 pages, 5 figures, APL Journal
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- 2024
16. Learning to Simulate Aerosol Dynamics with Graph Neural Networks
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Ferracina, Fabiana, Beeler, Payton, Halappanavar, Mahantesh, Krishnamoorthy, Bala, Minutoli, Marco, and Fierce, Laura
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Physics - Atmospheric and Oceanic Physics ,Computer Science - Machine Learning - Abstract
Aerosol effects on climate, weather, and air quality depend on characteristics of individual particles, which are tremendously diverse and change in time. Particle-resolved models are the only models able to capture this diversity in particle physiochemical properties, and these models are computationally expensive. As a strategy for accelerating particle-resolved microphysics models, we introduce Graph-based Learning of Aerosol Dynamics (GLAD) and use this model to train a surrogate of the particle-resolved model PartMC-MOSAIC. GLAD implements a Graph Network-based Simulator (GNS), a machine learning framework that has been used to simulate particle-based fluid dynamics models. In GLAD, each particle is represented as a node in a graph, and the evolution of the particle population over time is simulated through learned message passing. We demonstrate our GNS approach on a simple aerosol system that includes condensation of sulfuric acid onto particles composed of sulfate, black carbon, organic carbon, and water. A graph with particles as nodes is constructed, and a graph neural network (GNN) is then trained using the model output from PartMC-MOSAIC. The trained GNN can then be used for simulating and predicting aerosol dynamics over time. Results demonstrate the framework's ability to accurately learn chemical dynamics and generalize across different scenarios, achieving efficient training and prediction times. We evaluate the performance across three scenarios, highlighting the framework's robustness and adaptability in modeling aerosol microphysics and chemistry.
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- 2024
17. Almost-catalytic Computation
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Bisoyi, Sagar, Dinesh, Krishnamoorthy, Rai, Bhabya Deep, and Sarma, Jayalal
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Computer Science - Computational Complexity - Abstract
Designing algorithms for space bounded models with restoration requirements on the space used by the algorithm is an important challenge posed about the catalytic computation model introduced by Buhrman et al. (2014). Motivated by the scenarios where we do not need to restore unless is useful, we define $ACL(A)$ to be the class of languages that can be accepted by almost-catalytic Turing machines with respect to $A$ (which we call the catalytic set), that uses at most $c\log n$ work space and $n^c$ catalytic space. We show that if there are almost-catalytic algorithms for a problem with catalytic set as $A \subseteq \Sigma^*$ and its complement respectively, then the problem can be solved by a ZPP algorithm. Using this, we derive that to design catalytic algorithms, it suffices to design almost-catalytic algorithms where the catalytic set is the set of strings of odd weight ($PARITY$). Towards this, we consider two complexity measures of the set $A$ which are maximized for $PARITY$ - random projection complexity (${\cal R}(A)$) and the subcube partition complexity (${\cal P}(A)$). By making use of error-correcting codes, we show that for all $k \ge 1$, there is a language $A_k \subseteq \Sigma^*$ such that $DSPACE(n^k) \subseteq ACL(A_k)$ where for every $m \ge 1$, $\mathcal{R}(A_k \cap \{0,1\}^m) \ge \frac{m}{4}$ and $\mathcal{P}(A_k \cap \{0,1\}^m)=2^{m/4}$. This contrasts the catalytic machine model where it is unclear if it can accept all languages in $DSPACE(\log^{1+\epsilon} n)$ for any $\epsilon > 0$. Improving the partition complexity of the catalytic set $A$ further, we show that for all $k \ge 1$, there is a $A_k \subseteq \{0,1\}^*$ such that $\mathsf{DSPACE}(\log^k n) \subseteq ACL(A_k)$ where for every $m \ge 1$, $\mathcal{R}(A_k \cap \{0,1\}^m) \ge \frac{m}{4}$ and $\mathcal{P}(A_k \cap \{0,1\}^m)=2^{m/4+\Omega(\log m)}$., Comment: 22 pages, A new lower bound on the subcube partition complexity of Hamming balls (Proposition 2.6 and Lemma 2.7), improving the bound and fixing an error in the previous version
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- 2024
18. Dielectric Reliability and Interface Trap Characterization in MOCVD grown In-situ Al$_2$O$_3$ on $\beta$-Ga$_2$O$_3$
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Roy, Saurav, Bhattacharyya, Arkka, Peterson, Carl, and Krishnamoorthy, Sriram
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Condensed Matter - Materials Science ,Physics - Applied Physics - Abstract
In this article, we investigate the in-situ growth of Al$_2$O$_3$ on $\beta$-Ga$_2$O$_3$ using metal-organic chemical vapor deposition (MOCVD) at a high temperature of 800{\deg}C. The Al$_2$O$_3$ is grown within the same reactor as the $\beta$-Ga$_2$O$_3$, employing trimethylaluminum (TMAl) and O$_2$ as precursors without breaking the vacuum. We characterize the shallow and deep-level traps through stressed capacitance-voltage (C-V) and photo-assisted C-V methods. The high-temperature deposited dielectric demonstrates an impressive breakdown field of approximately 10 MV/cm. Furthermore, we evaluate the reliability and lifetime of the dielectrics using time-dependent dielectric breakdown (TDDB) measurements. By modifying the dielectric deposition process to include a high-temperature (800{\deg}C) thin interfacial layer and a low-temperature (600{\deg}C) bulk layer, we report a 10-year lifetime under a stress field of 3.5 MV/cm along a breakdown field of 7.8 MV/cm.
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- 2024
19. Watkins's conjecture for elliptic curves with a rational torsion
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Bhakta, Subham and Krishnamoorthy, Srilakshmi
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Mathematics - Number Theory ,Primary 11F30, 11L07, Secondary 11F52, 11F80 - Abstract
Watkins's conjecture suggests that for an elliptic curve $E/\mathbb{Q}$, the rank of the group $E(\mathbb{Q})$ of rational points is bounded above by $\nu_2 (m_E)$, where $m_E$ is the modular degree associated with $E$. It is known that Watkins's conjecture holds on average. This article investigates the conjecture over certain thin families of elliptic curves. For example, for prime $\ell$, we quantify the elliptic curves featuring a rational $\ell$-torsion that satisfies Watkins's conjecture. Additionally, the study extends to a broader context, investigating the inequality $\mathrm{rank}(E(\mathbb{Q}))+M\leq \nu_2(m_E)$ for any positive integer $M$., Comment: 26 pages; comments, and feedback are welcome
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- 2024
20. Record-High Electron Mobility and Controlled Low 10$^{15}$ cm$^{-3}$ Si-doping in (010) $\beta$-Ga$_2$O$_3$ Epitaxial Drift Layers
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Peterson, Carl, Bhattacharyya, Arkka, Chanchaiworawit, Kittamet, Kahler, Rachel, Roy, Saurav, Liu, Yizheng, Rebollo, Steve, Kallistova, Anna, Mates, Thomas E., and Krishnamoorthy, Sriram
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Physics - Applied Physics - Abstract
We report on metalorganic chemical vapor deposition (MOCVD) growth of controllably Si-doped 4.5 $\mu$m thick $\beta$-Ga$_2$O$_3$ films with electron concentrations in the 10$^{15}$ cm$^{-3}$ range and record-high room temperature Hall electron mobilities of up to 200 cm$^2$/V.s, reaching the predicted theoretical maximum room temperature mobility value for $\beta$-Ga$_2$O$_3$. Growth of the homoepitaxial films was performed on Fe-doped (010) $\beta$-Ga$_2$O$_3$ substrates at a growth rate of 1.9 $\mu$m/hr using TEGa as the Gallium precursor. To probe the background electron concentration, an unintentionally doped film was grown with a Hall concentration of 3.43 x 10$^{15}$ cm$^{-3}$ and Hall mobility of 196 cm$^2$/V.s. Growth of intentionally Si-Doped films was accomplished by fixing all growth conditions and varying only the silane flow, with controllable Hall electron concentrations ranging from 4.38 x 10$^{15}$ cm$^{-3}$ to 8.30 x 10$^{15}$ cm$^{-3}$ and exceptional Hall mobilities ranging from 194 - 200 cm$^2$/V.s demonstrated. C-V measurements showed a flat charge profile with the N$_D^+$ - N$_A^-$ values correlating well with the Hall-measured electron concentration in the films. SIMS measurements showed the silicon atomic concentration matched the Hall electron concentration with Carbon and Hydrogen below detection limit in the films. The Hall, C-V, and SIMS data indicate the growth of high-quality 4.5 $\mu$m thick $\beta$-Ga$_2$O$_3$ films and controllable doping into the mid 10$^{15}$ cm$^{-3}$ range. These results demonstrate MOCVD growth of electronics grade record-high mobility, low carrier density, and thick $\beta$-Ga$_2$O$_3$ drift layers for next generation vertical $\beta$-Ga$_2$O$_3$ power devices., Comment: 16 Pages, 10 Figures, 2 Tables
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- 2024
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21. Geophysical Observations of the 24 September 2023 OSIRIS-REx Sample Return Capsule Re-Entry
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Silber, Elizabeth A., Bowman, Daniel C., Carr, Chris G., Eisenberg, David P., Elbing, Brian R., Fernando, Benjamin, Garcés, Milton A., Haaser, Robert, Krishnamoorthy, Siddharth, Langston, Charles A., Nishikawa, Yasuhiro, Webster, Jeremy, Anderson, Jacob F., Arrowsmith, Stephen, Bazargan, Sonia, Beardslee, Luke, Beck, Brant, Bishop, Jordan W., Blom, Philip, Bracht, Grant, Chichester, David L., Christe, Anthony, Clarke, Jacob, Cummins, Kenneth, Cutts, James, Danielson, Lisa, Donahue, Carly, Eack, Kenneth, Fleigle, Michael, Fox, Douglas, Goel, Ashish, Green, David, Hasumi, Yuta, Hayward, Chris, Hicks, Dan, Hix, Jay, Horton, Stephen, Hough, Emalee, Huber, David P., Hunt, Madeline A., Inman, Jennifer, Islam, S. M. Ariful, Izraelevitz, Jacob, Jacob, Jamey D., Johnson, James, KC, Real J., Komjathy, Attila, Lam, Eric, LaPierre, Justin, Lewis, Kevin, Lewis, Richard D., Liu, Patrick, Martire, Léo, McCleary, Meaghan, McGhee, Elisa A., Mitra, Ipsita, Nag, Amitabh, Giraldo, Luis Ocampo, Pearson, Karen, Plaisir, Mathieu, Popenhagen, Sarah K., Rassoul, Hamid, Giannone, Miro Ronac, Samnani, Mirza, Schmerr, Nicholas, Spillman, Kate, Srinivas, Girish, Takazawa, Samuel K., Tempert, Alex, Turley, Reagan, Van Beek, Cory, Viens, Loïc, Walsh, Owen A., Weinstein, Nathan, White, Robert, Williams, Brian, Wilson, Trevor C., Wyckoff, Shirin, Yamamoto, Masa-yuki, Yap, Zachary, Yoshiyama, Tyler, and Zeiler, Cleat
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Geophysics - Abstract
Sample Return Capsules (SRCs) entering Earth's atmosphere at hypervelocity from interplanetary space are a valuable resource for studying meteor phenomena. The 24 September 2023 arrival of the OSIRIS-REx (Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer) SRC provided an unprecedented chance for geophysical observations of a well-characterized source with known parameters, including timing and trajectory. A collaborative effort involving researchers from 16 institutions executed a carefully planned geophysical observational campaign at strategically chosen locations, deploying over 400 ground-based sensors encompassing infrasound, seismic, distributed acoustic sensing (DAS), and GPS technologies. Additionally, balloons equipped with infrasound sensors were launched to capture signals at higher altitudes. This campaign (the largest of its kind so far) yielded a wealth of invaluable data anticipated to fuel scientific inquiry for years to come. The success of the observational campaign is evidenced by the near-universal detection of signals across instruments, both proximal and distal. This paper presents a comprehensive overview of the collective scientific effort, field deployment, and preliminary findings. The early findings have the potential to inform future space missions and terrestrial campaigns, contributing to our understanding of meteoroid interactions with planetary atmospheres. Furthermore, the dataset collected during this campaign will improve entry and propagation models as well as augment the study of atmospheric dynamics and shock phenomena generated by meteoroids and similar sources., Comment: 87 pages, 14 figures
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- 2024
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22. Exploring the Therapeutic Potential of Terminalia chebula Retz. in Alleviating the Complications of Letrozole-Induced PCOS in Rat Model
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Kalimuthu, Vignesh, Chandran Manimegalai, Swathi, Venkatesan, Ramya, Krishnamoorthy, Sathiya Priya, Dey, Nigamananda, Ramesh, Thiyagarajan, and Balamuthu, Kadalmani
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- 2025
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23. Chitin Extraction from Lutjanus campechanus for Sustainable Bio-plastic Production (Red Snapper)
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Sagaya Deva Niranjana, X. and Krishnamoorthy, R.
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- 2025
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24. Clinical outcomes after complex and high-risk percutaneous coronary intervention according to baseline chronic kidney disease
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Di Muro, Francesca Maria, Sartori, Samantha, Vogel, Birgit, Feng, Yihan, Gitto, Mauro, Oliva, Angelo, Krishnan, Prakash, Bay, Benjamin, Sweeny, Joseph, Moreno, Pedro, Krishnamoorthy, Parasuram, Dangas, George, Kini, Annapoorna, Sharma, Samin, and Mehran, Roxana
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- 2025
- Full Text
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25. Mindful machines: evaluating ChatGPT’s impact on higher education
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Krishnamoorthy, Ravichandran, Srivastava, Mini, and Khanna, Divita
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- 2025
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26. MAP/Ek/1 queue with working vacation and N-policy
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Sindhu, S. and Krishnamoorthy, Achyutha
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- 2025
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27. Impact of environments on combining ability and heterosis in cotton (Gossypium hirsutum L.)
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Meera, Mundakochi, Subramanian, Alagesan, Premalatha, Nallathambi, Boopathi, Narayanan Manikanda, Vijayalakshmi, Dhashnamurthi, Iyanar, Krishnamoorthy, Thangapandian, Ramalingam, and Patil, Santosh Ganapati
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- 2025
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28. Adult head circumference and the risk of cancer: a retrospective cohort study
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Krishnamoorthy, Suhas, Mak, Jonathan K. L., Tan, Kathryn C. B., Li, Gloria H. Y., and Cheung, Ching-Lung
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- 2025
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29. The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9: ACUTE MYELOID LEUKEMIA
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Krishnamoorthy, Vignesh, Daly, John, Kim, Jimmy, Piatnitca, Lidia, Yuen, Katie A., Kumar, Bhoj, Taherzadeh Ghahfarrokhi, Mehrnoush, Bui, Tom Q. T., Azadi, Parastoo, Vu, Ly P., and Wisnovsky, Simon
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- 2025
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30. Graphene Oxide Assisted Humidity Sensing Antenna Sensor
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Singh, Vishwanath Pratap, Kandasamy, Krishnamoorthy, and Rahman, Mohammad Rizwanur
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- 2025
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31. Essential oil profile of Garcinia Pushpangadaniana, a recently described species from the Western Ghats of India
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Sharma, Pranav Murali, Krishnamoorthy, Devanathan, Velusamy, Sundaresan, and V S, Pragadheesh
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- 2025
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32. A general-purpose approach to multi-agent Bayesian optimization across decomposition methods
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Krishnamoorthy, Dinesh
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- 2025
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33. Synergizing reaction systems and graph rewriting: a hyper-edge replacement PR system
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Krishnamoorthy, Vinodhini and Sankar, Meena Parvathy
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- 2025
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34. Biochar-based controlled-release fertilizers for enhancing plant growth and environmental sustainability: a review
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Palansooriya, Kumuduni Niroshika, Dissanayake, Pavani Dulanja, El-Naggar, Ali, Gayesha, Erandi, Wijesekara, Hasintha, Krishnamoorthy, Nageshwari, Cai, Yanjiang, and Chang, Scott X.
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- 2025
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35. Knowledge Graphs for Representing Knowledge Progression of Students across Heterogeneous Learning Systems
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M.D., Soumya and Krishnamoorthy, Shivsubramani
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- 2025
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36. AI in higher education: tapping educators’ perspective
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Krishnamoorthy, Ravichandran, Srivastava, Mini, and Khanna, Divita
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- 2025
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37. Moments of non-normal number fields-II: Moments of non-normal number fields-II
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Krishnamoorthy, Krishnarjun
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- 2025
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38. Integrating GIS-Remote Sensing: A Comprehensive Approach to Predict Oceanographic Health and Coastal Dynamics
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Krishnamoorthy, R., Tanaka, Kazuaki, and Begum, M. Amina
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- 2025
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39. A characterization study on toughening natural fibre composites using functionalized barely husk biosilica
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Krishnamoorthy, N., Nagabhooshanam, N., Rao, Pothamsetty Kasi V., Verma, Rajesh, Kumar, D. Sendil, Sankar, Gullapalli Ajay, Kumar, Boddepalli Kiran, and Mohanavel, V.
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- 2025
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40. Evaluation of Raw and Detoxified Neem Cake in the Diets of Wistar Rats (Rattus norvegicus) as Partial Protein Supplement
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Rao, S.B.N., Dineshkumar, D., Krishnamoorthy, P., Jash, S., and Reddy, I.J.
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- 2018
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41. Nonlinear interferometry-based metrology of magneto-optical properties at infrared wavelengths
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Chakraborty, Tanmoy, Produit, Thomas, Krishnamoorthy, Harish N S, Soci, Cesare, and Paterova, Anna V.
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Physics - Optics ,Physics - Applied Physics ,Quantum Physics - Abstract
Magneto-optical properties of materials are utilized in numerous applications both in scientific research and industries. The novel properties of these materials can be further investigated by performing metrology in the infrared wavelength range, thereby enriching their potential applications. However, current infrared metrology techniques can be challenging and resource-intensive due to the unavailability of suitable components. To address these challenges, we propose and demonstrate a set of measurements based on nonlinear interferometry, which allows us investigating magneto-optical properties of materials at infrared wavelength range by performing optical detection at the visible range. For a proof-of-principle study, we measure the Verdet constant of a bismuth-iron-garnet, over a spectral bandwidth of 600 nm in the near-IR range., Comment: 10 pages, 12 fugures
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- 2024
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42. Hydrogen and Battery Based Energy Storage System (ESS) for Future DC Microgrids
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Diabate, Massiagbe, Vriend, Timothy, Krishnamoorthy, Harish S, and Shi, Jian
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Electrical Engineering and Systems Science - Systems and Control - Abstract
In this paper, a hydrogen-based energy storage system (ESS) is proposed for DC microgrids, which can potentially be integrated with battery ESS to meet the needs of future grids with high renewable penetration. Hydrogen-based ESS can provide a stable energy supply for a long time but has a slower response than battery ESSs. However, a combination of battery and hydrogen storage provides stable energy for an extended period of time and can easily handle the sudden demands and surpluses of the microgrid. One of the main challenges in this system is the integration of power electronics with fuel cell technology to convert renewable energy into electricity seamlessly. This paper proposes a system that uses an isolated DC-DC converter to activate clean hydrogen production using an electrolyzer and then pressurize the hydrogen to store in a tank. The pressured hydrogen becomes an essential input to the fuel cell, which regulates and transforms it into electricity. The electricity produced is then transferred to the grid using a DC-DC boost converter. A Simulink model of the hybrid system with a 1 kV DC bus voltage is used to demonstrate the hydrogen production and fuel cell behavior based on the demand and surplus power of the loads. The proposed system simulates aspects of the power conversion, electrolyzer, storage tank, and fuel cell needed for the proposed hybrid ESS. Due to its economic feasibility, the polymer electrolyte membrane (PEM) is the primary technology considered for the electrolyzer and fuel cell., Comment: A 5-pages Digest paper summarizes in detail the work done
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- 2024
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43. Radio Resource Management Design for RSMA: Optimization of Beamforming, User Admission, and Discrete/Continuous Rates with Imperfect SIC
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Abanto-Leon, L. F., Krishnamoorthy, A., Garcia-Saavedra, A., Sim, G. H., Schober, R., and Hollick, M.
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Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Emerging Technologies ,Computer Science - Information Theory ,Computer Science - Networking and Internet Architecture - Abstract
This paper investigates the radio resource management (RRM) design for multiuser rate-splitting multiple access (RSMA), accounting for various characteristics of practical wireless systems, such as the use of discrete rates, the inability to serve all users, and the imperfect successive interference cancellation (SIC). Specifically, failure to consider these characteristics in RRM design may lead to inefficient use of radio resources. Therefore, we formulate the RRM of RSMA as optimization problems to maximize respectively the weighted sum rate (WSR) and weighted energy efficiency (WEE), and jointly optimize the beamforming, user admission, discrete/continuous rates, accounting for imperfect SIC, which result in nonconvex mixed-integer nonlinear programs that are challenging to solve. Despite the difficulty of the optimization problems, we develop algorithms that can find high-quality solutions. We show via simulations that carefully accounting for the aforementioned characteristics, can lead to significant gains. Precisely, by considering that transmission rates are discrete, the transmit power can be utilized more intelligently, allocating just enough power to guarantee a given discrete rate. Additionally, we reveal that user admission plays a crucial role in RSMA, enabling additional gains compared to random admission by facilitating the servicing of selected users with mutually beneficial channel characteristics. Furthermore, provisioning for possibly imperfect SIC makes RSMA more robust and reliable.
- Published
- 2024
44. LLM-Based Section Identifiers Excel on Open Source but Stumble in Real World Applications
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Krishnamoorthy, Saranya, Singh, Ayush, and Tafreshi, Shabnam
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Electronic health records (EHR) even though a boon for healthcare practitioners, are growing convoluted and longer every day. Sifting around these lengthy EHRs is taxing and becomes a cumbersome part of physician-patient interaction. Several approaches have been proposed to help alleviate this prevalent issue either via summarization or sectioning, however, only a few approaches have truly been helpful in the past. With the rise of automated methods, machine learning (ML) has shown promise in solving the task of identifying relevant sections in EHR. However, most ML methods rely on labeled data which is difficult to get in healthcare. Large language models (LLMs) on the other hand, have performed impressive feats in natural language processing (NLP), that too in a zero-shot manner, i.e. without any labeled data. To that end, we propose using LLMs to identify relevant section headers. We find that GPT-4 can effectively solve the task on both zero and few-shot settings as well as segment dramatically better than state-of-the-art methods. Additionally, we also annotate a much harder real world dataset and find that GPT-4 struggles to perform well, alluding to further research and harder benchmarks., Comment: To appear in NAACL 2024 at the 6th Clinical Natural Language Processing Workshop
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- 2024
45. Effective uniaxial dielectric function tensor and optical phonons in ($\bar{2}01$)-plane oriented $\beta$-Ga$_2$O$_3$ films with equally-distributed six-fold rotation domains
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Mock, Alyssa, Richter, Steffen, Papamichail, Alexis, Stanishev, Vallery, Ghezellou, Misagh, Ul-Hassan, Jawad, Popp, Andreas, Anooz, Saud Bin, Gogova, Daniella, Ranga, Praneeth, Krishnamoorthy, Sriram, Korlacki, Rafal, Schubert, Mathias, and Darakchieva, Vanya
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Condensed Matter - Materials Science - Abstract
Monoclinic $\beta$-Ga$_2$O$_3$ films grown on $c$-plane sapphire have been shown to exhibit six $(\bar{2}01)$-plane oriented domains, which are equally-spaced-by-rotation around the surface normal and equally-sized-by-volume that render the film optical response effectively uniaxial. We derive and discuss an optical model suitable for ellipsometry data analysis of such films. We model mid- and far-infrared ellipsometry data from undoped and electrically insulating films with an effective uniaxial dielectric tensor based on projections of all phonon modes within the rotation domains parallel and perpendicular to the sample normal, i.e., to the reciprocal lattice vector $\mathbf{g}_{\bar{2}01}$. Two effective response functions are described by model, and found sufficient to calculate ellipsometry data that best-match measured ellipsometry data from a representative film. We propose to render either effective dielectric functions, or inverse effective dielectric functions, each separately for electric field directions parallel and perpendicular to $\mathbf{g}_{\bar{2}01}$, by sums of Lorentz oscillators, which permit to determine either sets of transverse optical phonon mode parameters, or sets of longitudinal optical phonon mode parameters, respectively. Transverse optical modes common to both dielectric functions can be traced back to single crystal modes with $B_{\mathrm{u}}$ character, while modes with $A_{\mathrm{u}}$ character only appear within the dielectric function for polarization perpendicular to the sample surface. The thereby obtained parameter sets reveal all phonon modes anticipated from averaging over the six-fold rotation domains of single crystal $\beta$-Ga$_2$O$_3$, but with slightly shifted transverse optical, and completely different longitudinal optical phonon modes., Comment: 14 pgaes, 8 figures
- Published
- 2024
46. Box Filtration
- Author
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Alvarado, Enrique, Gupta, Prashant, and Krishnamoorthy, Bala
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Computer Science - Computational Geometry ,Mathematics - Algebraic Topology ,55N31, 62R40 - Abstract
We define a new framework that unifies the filtration and mapper approaches from TDA, and present efficient algorithms to compute it. Termed the box filtration of a PCD, we grow boxes (hyperrectangles) that are not necessarily centered at each point (in place of balls centered at points). We grow the boxes non-uniformly and asymmetrically in different dimensions based on the distribution of points. We present two approaches to handle the boxes: a point cover where each point is assigned its own box at start, and a pixel cover that works with a pixelization of the space of the PCD. Any box cover in either setting automatically gives a mapper of the PCD. We show that the persistence diagrams generated by the box filtration using both point and pixel covers satisfy the classical stability based on the Gromov-Hausdorff distance. Using boxes also implies that the box filtration is identical for pairwise or higher order intersections whereas the VR and Cech filtration are not the same. Growth in each dimension is computed by solving a linear program (LP) that optimizes a cost functional balancing the cost of expansion and benefit of including more points in the box. The box filtration algorithm runs in $O(m|U(0)|\log(mn\pi)L(q))$ time, where $m$ is number of steps of increments considered for box growth, $|U(0)|$ is the number of boxes in the initial cover ($\leq$ number of points), $\pi$ is the step length for increasing each box dimension, each LP is solved in $O(L(q))$ time, $n$ is the PCD dimension, and $q = n \times |X|$. We demonstrate through multiple examples that the box filtration can produce more accurate results to summarize the topology of the PCD than VR and distance-to-measure (DTM) filtrations. Software for our implementation is available at https://github.com/pragup/Box-Filteration., Comment: 17 figures
- Published
- 2024
47. Performance Characterization of Heliotrope Solar Hot-Air Balloons during Multihour Stratospheric Flights
- Author
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Swaim, Taylor D., Hough, Emalee, Yap, Zachary, Jacob, Jamey D., Krishnamoorthy, Siddharth, Bowman, Daniel C., Martire, Léo, Komjathy, Attila, and Elbing, Brian R.
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Physics - Space Physics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Atmospheric and Oceanic Physics - Abstract
Heliotropes are passive solar hot air balloons that are capable of achieving nearly level flight within the lower stratosphere for several hours. These inexpensive flight platforms enable stratospheric sensing with high-cadence enabled by the low cost to manufacture, but their performance has not yet been assessed systematically. During July to September of 2021, 29 heliotropes were successfully launched from Oklahoma and achieved float altitude as part of the Balloon-based Acoustic Seismology Study (BASS). All of the heliotrope envelopes were nearly identical with only minor variations to the flight line throughout the campaign. Flight data collected during this campaign comprise a large sample to characterize the typical heliotrope flight behavior during launch, ascent, float, and descent. Each flight stage is characterized, dependence on various parameters is quantified, and a discussion of nominal and anomalous flights is provided.
- Published
- 2024
- Full Text
- View/download PDF
48. Predictive Analytics of Varieties of Potatoes
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Ferracina, Fabiana, Krishnamoorthy, Bala, Halappanavar, Mahantesh, Hu, Shengwei, and Sathuvalli, Vidyasagar
- Subjects
Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
We explore the application of machine learning algorithms specifically to enhance the selection process of Russet potato clones in breeding trials by predicting their suitability for advancement. This study addresses the challenge of efficiently identifying high-yield, disease-resistant, and climate-resilient potato varieties that meet processing industry standards. Leveraging manually collected data from trials in the state of Oregon, we investigate the potential of a wide variety of state-of-the-art binary classification models. The dataset includes 1086 clones, with data on 38 attributes recorded for each clone, focusing on yield, size, appearance, and frying characteristics, with several control varieties planted consistently across four Oregon regions from 2013-2021. We conduct a comprehensive analysis of the dataset that includes preprocessing, feature engineering, and imputation to address missing values. We focus on several key metrics such as accuracy, F1-score, and Matthews correlation coefficient (MCC) for model evaluation. The top-performing models, namely a neural network classifier (Neural Net), histogram-based gradient boosting classifier (HGBC), and a support vector machine classifier (SVM), demonstrate consistent and significant results. To further validate our findings, we conduct a simulation study. By simulating different data-generating scenarios, we assess model robustness and performance through true positive, true negative, false positive, and false negative distributions, area under the receiver operating characteristic curve (AUC-ROC) and MCC. The simulation results highlight that non-linear models like SVM and HGBC consistently show higher AUC-ROC and MCC than logistic regression (LR), thus outperforming the traditional linear model across various distributions, and emphasizing the importance of model selection and tuning in agricultural trials., Comment: Minor revision; to appear in Crop Sciences
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- 2024
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49. Characterizing Long COVID in Children and Adolescents
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Gross, Rachel S, Thaweethai, Tanayott, Kleinman, Lawrence C, Snowden, Jessica N, Rosenzweig, Erika B, Milner, Joshua D, Tantisira, Kelan G, Rhee, Kyung E, Jernigan, Terry L, Kinser, Patricia A, Salisbury, Amy L, Warburton, David, Mohandas, Sindhu, Wood, John C, Newburger, Jane W, Truong, Dongngan T, Flaherman, Valerie J, Metz, Torri D, Karlson, Elizabeth W, Chibnik, Lori B, Pant, Deepti B, Krishnamoorthy, Aparna, Gallagher, Richard, Lamendola-Essel, Michelle F, Hasson, Denise C, Katz, Stuart D, Yin, Shonna, Dreyer, Benard P, Carmilani, Megan, Coombs, K, Fitzgerald, Megan L, Güthe, Nick, Hornig, Mady, Letts, Rebecca J, Peddie, Aimee K, Taylor, Brittany D, Foulkes, Andrea S, Stockwell, Melissa S, Balaraman, Venkataraman, Bogie, Amanda, Bukulmez, Hulya, Dozor, Allen J, Eckrich, Daniel, Elliott, Amy J, Evans, Danielle N, Farkas, Jonathan S, Faustino, E Vincent S, Fischer, Laura, Gaur, Sunanda, Harahsheh, Ashraf S, Hasan, Uzma N, Hsia, Daniel S, Huerta-Montanez, Gredia, Hummel, Kathy D, Kadish, Matt P, Kaelber, David C, Krishnan, Sankaran, Kosut, Jessica S, Larrabee, Jerry, Lim, Peter Paul C, Michelow, Ian C, Oliveira, Carlos R, Raissy, Hengameh, Rosario-Pabon, Zaira, Ross, Judith L, Sato, Alice I, Stevenson, Michelle D, Talavera-Barber, Maria M, Teufel, Ronald J, Weakley, Kathryn E, Zimmerman, Emily, Bind, Marie-Abele C, Chan, James, Guan, Zoe, Morse, Richard E, Reeder, Harrison T, Akshoomoff, Natascha, Aschner, Judy L, Bhattacharjee, Rakesh, Cottrell, Lesley A, Cowan, Kelly, D'Sa, Viren A, Fiks, Alexander G, Gennaro, Maria L, Irby, Katherine, Khare, Manaswitha, Landeo Guttierrez, Jeremy, McCulloh, Russell J, Narang, Shalu, Ness- Cochinwala, Manette, Nolan, Sheila, Palumbo, Paul, Ryu, Julie, Salazar, Juan C, Selvarangan, Rangaraj, Stein, Cheryl R, Werzberger, Alan, Zempsky, William T, Aupperle, Robin, and Baker, Fiona C
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Emerging Infectious Diseases ,Neurosciences ,Coronaviruses ,Infectious Diseases ,Pediatric ,Minority Health ,Pain Research ,Infection ,Good Health and Well Being ,RECOVER-Pediatrics Consortium ,RECOVER-Pediatrics Group Authors ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
ImportanceMost research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment.ObjectiveTo identify the most common prolonged symptoms experienced by children (aged 6 to 17 years) after SARS-CoV-2 infection, how these symptoms differ by age (school-age [6-11 years] vs adolescents [12-17 years]), how they cluster into distinct phenotypes, and what symptoms in combination could be used as an empirically derived index to assist researchers to study the likely presence of PASC.Design, setting, and participantsMulticenter longitudinal observational cohort study with participants recruited from more than 60 US health care and community settings between March 2022 and December 2023, including school-age children and adolescents with and without SARS-CoV-2 infection history.ExposureSARS-CoV-2 infection.Main outcomes and measuresPASC and 89 prolonged symptoms across 9 symptom domains.ResultsA total of 898 school-age children (751 with previous SARS-CoV-2 infection [referred to as infected] and 147 without [referred to as uninfected]; mean age, 8.6 years; 49% female; 11% were Black or African American, 34% were Hispanic, Latino, or Spanish, and 60% were White) and 4469 adolescents (3109 infected and 1360 uninfected; mean age, 14.8 years; 48% female; 13% were Black or African American, 21% were Hispanic, Latino, or Spanish, and 73% were White) were included. Median time between first infection and symptom survey was 506 days for school-age children and 556 days for adolescents. In models adjusted for sex and race and ethnicity, 14 symptoms in both school-age children and adolescents were more common in those with SARS-CoV-2 infection history compared with those without infection history, with 4 additional symptoms in school-age children only and 3 in adolescents only. These symptoms affected almost every organ system. Combinations of symptoms most associated with infection history were identified to form a PASC research index for each age group; these indices correlated with poorer overall health and quality of life. The index emphasizes neurocognitive, pain, and gastrointestinal symptoms in school-age children but change or loss in smell or taste, pain, and fatigue/malaise-related symptoms in adolescents. Clustering analyses identified 4 PASC symptom phenotypes in school-age children and 3 in adolescents.Conclusions and relevanceThis study developed research indices for characterizing PASC in children and adolescents. Symptom patterns were similar but distinguishable between the 2 groups, highlighting the importance of characterizing PASC separately for these age ranges.
- Published
- 2024
50. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study.
- Author
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Royce-Nagel, Galen, Jarzebowski, Mary, Wongsripuemtet, Pattrapun, Krishnamoorthy, Vijay, Fuller, Matthew, Ohnuma, Tetsu, Treggiari, Miriam, Yaport, Miguel, Cobert, Julien, Garrigan, Ethan, Bartz, Raquel, and Raghunathan, Karthik
- Subjects
Humans ,Ketamine ,Respiration ,Artificial ,Retrospective Studies ,Male ,Female ,COVID-19 ,Middle Aged ,Hospital Mortality ,Aged ,Length of Stay ,Intensive Care Units ,Cohort Studies ,Hypnotics and Sedatives ,SARS-CoV-2 ,Hospital Costs ,Propensity Score - Abstract
OBJECTIVES: To describe the utilization of early ketamine use among patients mechanically ventilated for COVID-19, and examine associations with in-hospital mortality and other clinical outcomes. DESIGN: Retrospective cohort study. SETTING: Six hundred ten hospitals contributing data to the Premier Healthcare Database between April 2020 and June 2021. PATIENTS: Adults with COVID-19 and greater than or equal to 2 consecutive days of mechanical ventilation within 5 days of hospitalization. INTERVENTION: The exposures were early ketamine use initiated within 2 days of intubation and continued for greater than 1 day. MEASUREMENTS: Primary was hospital mortality. Secondary outcomes included length of stay (LOS) in the hospital and ICUs, ventilator days, vasopressor days, renal replacement therapy (RRT), and total hospital cost. The propensity score matching analysis was used to adjust for confounders. MAIN RESULTS: Among 42,954 patients, 1,423 (3.3%) were exposed to early ketamine use. After propensity score matching including 1,390 patients in each group, recipients of ketamine infusions were associated with higher hospital mortality (52.5% vs. 45.9%, risk ratio: 1.14, [1.06-1.23]), longer median ICU stay (13 vs. 12 d, mean ratio [MR]: 1.15 [1.08-1.23]), and longer ventilator days (12 vs. 11 d, MR: 1.19 [1.12-1.27]). There were no associations for hospital LOS (17 [10-27] vs. 17 [9-28], MR: 1.05 [0.99-1.12]), vasopressor days (4 vs. 4, MR: 1.04 [0.95-1.14]), and RRT (22.9% vs. 21.7%, RR: 1.05 [0.92-1.21]). Total hospital cost was higher (median $72,481 vs. $65,584, MR: 1.11 [1.05-1.19]). CONCLUSIONS: In a diverse sample of U.S. hospitals, about one in 30 patients mechanically ventilated with COVID-19 received ketamine infusions. Early ketamine may have an association with higher hospital mortality, increased total cost, ICU stay, and ventilator days, but no associations for hospital LOS, vasopressor days, and RRT. However, confounding by the severity of illness might occur due to higher extracorporeal membrane oxygenation and RRT use in the ketamine group. Further randomized trials are needed to better understand the role of ketamine infusions in the management of critically ill patients.
- Published
- 2024
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