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282 results on '"Krishnan, Rajesh"'

1. BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells

Author

Thakore, Pratiksha I., Schnell, Alexandra, Huang, Linglin, Zhao, Maryann, Hou, Yu, Christian, Elena, Zaghouani, Sarah, Wang, Chao, Singh, Vasundhara, Singaraju, Anvita, Krishnan, Rajesh Kumar, Kozoriz, Deneen, Ma, Sai, Sankar, Venkat, Notarbartolo, Samuele, Buenrostro, Jason D., Sallusto, Federica, Patsopoulos, Nikolaos A., Rozenblatt-Rosen, Orit, Kuchroo, Vijay K., and Regev, Aviv

Published
2024
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2. APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Author

Yin, Zhuoran, Rosenzweig, Neta, Kleemann, Kilian L., Zhang, Xiaoming, Brandão, Wesley, Margeta, Milica A., Schroeder, Caitlin, Sivanathan, Kisha N., Silveira, Sebastian, Gauthier, Christian, Mallah, Dania, Pitts, Kristen M., Durao, Ana, Herron, Shawn, Shorey, Hannah, Cheng, Yiran, Barry, Jen-Li, Krishnan, Rajesh K., Wakelin, Sam, Rhee, Jared, Yung, Anthony, Aronchik, Michael, Wang, Chao, Jain, Nimansha, Bao, Xin, Gerrits, Emma, Brouwer, Nieske, Deik, Amy, Tenen, Daniel G., Ikezu, Tsuneya, Santander, Nicolas G., McKinsey, Gabriel L., Baufeld, Caroline, Sheppard, Dean, Krasemann, Susanne, Nowarski, Roni, Eggen, Bart J. L., Clish, Clary, Tanzi, Rudolph E., Madore, Charlotte, Arnold, Thomas D., Holtzman, David M., and Butovsky, Oleg

Published
2023
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5. Experimental demonstration of high-entropy time of arrival based optical QRNG qualifying stringent statistical tests

Author

Banerjee, Anindita, Sethia, Anuj, Mogiligidda, Vijayalaxmi, Krishnan, Rajesh Kumar, AR, Meiyappan, Rajamani, Sairam, and Shenoy, Vivek

Subjects
Quantum Physics
Abstract

We report a demonstration of a high-entropy optical quantum random number generator (QRNG) based on photon arrival time. We have implemented the scheme with high-speed and high-precision electronics with a time resolution of 1 ps generating 115 Mbps raw data. The random bit generation efficiency is 8 bits per detection. The experimental data is quite consistent with theoretical estimation showing minimum bias. We apply a real-time information-theoretic randomness extractor to generate a final data rate of 109 Mbps. The randomness is rigorously evaluated against well-known statistical test suites of NIST, ENT, Diehard, TU-01 and Dieharder., Comment: 10 pages

Published
2021

7. On Single-Server Delegation of RSA

Author

Di Crescenzo, Giovanni, Khodjaeva, Matluba, Chen, Ta, Krishnan, Rajesh, Shur, David, Kahrobaei, Delaram, Shpilrain, Vladimir, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bella, Giampaolo, editor, Doinea, Mihai, editor, and Janicke, Helge, editor

Published
2023
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8. ChaQra: a cellular unit of the Indian quantum network

Author

Gupta, Shashank, Agarwal, Iteash, Mogiligidda, Vijayalaxmi, Kumar Krishnan, Rajesh, Chennuri, Sruthi, Aggarwal, Deepika, Hoodati, Anwesha, Cooper, Sheroy, Ranjan, Bilal Sheik, Mohammad, Bhavya, K. M., Hegde, Manasa, Krishna, M. Naveen, Chauhan, Amit Kumar, Korrapati, Mallikarjun, Singh, Sumit, Singh, J. B., Sud, Sunil, Gupta, Sunil, Pant, Sidhartha, Sankar, Agrawal, Neha, Ranjan, Ashish, Mohapatra, Piyush, Roopak, T., Ahmad, Arsh, Nanjunda, M., and Singh, Dilip

Published
2024
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11. On Single-Server Delegation of RSA

Author

Di Crescenzo, Giovanni, primary, Khodjaeva, Matluba, additional, Chen, Ta, additional, Krishnan, Rajesh, additional, Shur, David, additional, Kahrobaei, Delaram, additional, and Shpilrain, Vladimir, additional

Published
2023
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12. Human regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in multiple sclerosis

Author

Varghese, Johnna F., primary, Kaskow, Belinda J., additional, von Glehn, Felipe, additional, Case, Junning, additional, Li, Zhenhua, additional, Julé, Amélie M., additional, Berdan, Emma, additional, Ho Sui, Shannan Janelle, additional, Hu, Yong, additional, Krishnan, Rajesh, additional, Chitnis, Tanuja, additional, Kuchroo, Vijay K., additional, Weiner, Howard L., additional, and Baecher-Allan, Clare Mary, additional

Published
2024
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18. An analysis of the value of optimal routing and signal timing control strategy with connected autonomous vehicles.

Author

Li, Tang, Guo, Fangce, Krishnan, Rajesh, and Sivakumar, Aruna

Subjects
TRAVEL time (Traffic engineering), AUTONOMOUS vehicles, TRAVEL costs
Abstract

With the emergence of connected and automated technologies, Connected Autonomous Vehicles (CAVs) are able to communicate and interact with other vehicles and signal controllers. Vehicle to Vehicle (V2V) and Vehicle to Infrastructure (V2I) communications open up an opportunity to improve routing and signal timing efficiency with additional information from CAVs, such as prior travel time and signal green time. Most of the existing research on routing and signal timing for Human Driven Vehicles (HDVs) has to face the fact that human drivers only have partial knowledge about travel costs and traffic status on the road network, which typically reduces the system efficiency. In this paper, the impacts of additional information from CAVs on routing and signal timing efficiency in terms of total travel time have been investigated. An Optimal Routing and Signal Timing (ORST) control strategy for CAVs has been proposed and compared with four existing routing and signal timing strategies where drivers have different levels of information. The results of the simulation demonstrate that with additional information from CAVs, ORST can reduce about 49% of the total travel time compared with Stochastic User Equilibrium (SUE) and about 10% of the total travel time compared with User Equilibrium (UE). [ABSTRACT FROM AUTHOR]

Published
2024
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23. Secure and scalable match: overcoming the universal circuit bottleneck using group programs

Author

Krishnan, Rajesh and Sundaram, Ravi

Subjects
Computer Science - Cryptography and Security
Abstract

Confidential Content-Based Publish/Subscribe (C-CBPS) is an interaction (pub/sub) model that allows parties to exchange data while still protecting their security and privacy interests. In this paper we advance the state of the art in C-CBPS by showing how all predicate circuits in NC1 (logarithmic-depth, bounded fan-in) can be securely computed by a broker while guaranteeing perfect information-theoretic security. Previous work could handle only strictly shallower circuits (e.g. those with depth O(\sqrt{\lg n}) [SYY99, V76]. We present three protocols -- UGP-Match, FSGP-Match and OFSGP-Match -- all three are based on (2-decomposable randomized encodings of) group programs and handle circuits in NC1. UGP-Match is conceptually simple and has a clean proof of correctness but it is inefficient and impractical. FSGP-Match uses a "fixed structure" trick to achieve efficiency and scalability. And, finally, OFSGP-Match uses hand-optimized group programs to wring greater efficiencies. We complete our investigation with an experimental evaluation of a prototype implementation.

Published
2014

25. microRNA-92a promotes CNS autoimmunity by modulating the regulatory and inflammatory T cell balance

Author

Fujiwara, Mai, Raheja, Radhika, Garo, Lucien P., Ajay, Amrendra K., Kadowaki- Saga, Ryoko, Karandikar, Sukrut H., Gabriely, Galina, Krishnan, Rajesh, Beynon, Vanessa, Paul, Anu, Patel, Amee, Saxena, Shrishti, Hu, Dan, Healy, Brian C., Chitnis, Tanuja, Gandhi, Roopali, Weiner, Howard L., and Murugaiyan, Gopal

Subjects
T cells -- Genetic aspects -- Health aspects, Multiple sclerosis -- Development and progression -- Genetic aspects, Autoimmunity -- Genetic aspects -- Health aspects, MicroRNA -- Health aspects, Cellular control mechanisms -- Genetic aspects -- Health aspects, Health care industry
Abstract

A disequilibrium between immunosuppressive Tregs and inflammatory IL-17- producing Th17 cells is a hallmark of autoimmune diseases, including multiple sclerosis (MS). However, the molecular mechanisms underlying the Treg and Th17 imbalance in CNS autoimmunity remain largely unclear. Identifying the factors that drive this imbalance is of high clinical interest. Here, we report a major disease-promoting role for microRNA-92a (miR- 92a) in CNS autoimmunity. miR-92a was elevated in experimental autoimmune encephalomyelitis (EAE), and its loss attenuated EAE. Mechanistically, miR92a mediated EAE susceptibility in a T cell-intrinsic manner by restricting Treg induction and suppressive capacity, while supporting Th17 responses, by directly repressing the transcription factor Foxo1. Although miR-92a did not directly alter Th1 differentiation, it appeared to indirectly promote Th1 cells by inhibiting Treg responses. Correspondingly, miR-92a inhibitor therapy ameliorated EAE by concomitantly boosting Treg responses and dampening inflammatory T cell responses. Analogous to our findings in mice, miR-92a was elevated in [CD4.sup.+] T cells from patients with MS, and miR-92a silencing in patients' T cells promoted Treg development but limited Th17 differentiation. Together, our results demonstrate that miR-92a drives CNS autoimmunity by sustaining the Treg/Th17 imbalance and implicate miR-92a as a potential therapeutic target for MS., Introduction Multiple sclerosis (MS) and its animal model of experimental autoimmune encephalomyelitis (EAE) are mediated by dysregulated autoreactive T cell responses in the CNS that perpetuate neuroinflammation and neuronal damage [...]

Published
2022
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27. Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine

Author

Conway, Sarah, primary, Saxena, Shrishti, additional, Baecher-Allan, Clare, additional, Krishnan, Rajesh, additional, Houtchens, Maria, additional, Glanz, Bonnie, additional, Saraceno, Taylor J, additional, Polgar-Turcsanyi, Mariann, additional, Bose, Gauruv, additional, Bakshi, Rohit, additional, Bhattacharyya, Shamik, additional, Galetta, Kristin, additional, Kaplan, Tamara, additional, Severson, Christopher, additional, Singhal, Tarun, additional, Stazzone, Lynn, additional, Zurawski, Jonathan, additional, Paul, Anu, additional, Weiner, Howard L, additional, Healy, Brian C, additional, and Chitnis, Tanuja, additional

Published
2023
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28. Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease

Author

Rosenzweig, Neta, Kleemann, Kilian L., Rust, Thomas, Carpenter, Madison, Grucci, Madeline, Aronchik, Michael, Brouwer, Nieske, Valenbreder, Isabel, Cooper-Hohn, Joya, Iyer, Malvika, Krishnan, Rajesh K., Sivanathan, Kisha N., Brandão, Wesley, Yahya, Taha, Durao, Ana, Yin, Zhuoran, Chadarevian, Jean Paul, Properzi, Michael J., Nowarski, Roni, Davtyan, Hayk, Weiner, Howard L., Blurton-Jones, Mathew, Yang, Hyun-Sik, Eggen, Bart J. L., Sperling, Reisa A., and Butovsky, Oleg

Abstract

APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging single-cell transcriptomics across APOE variants in both sexes, multiplex flow cytometry and validation in two independent cohorts of APOE4 female carriers with AD, we identify a new subset of neutrophils interacting with microglia associated with cognitive impairment. This phenotype is defined by increased interleukin (IL)-17 and IL-1 coexpressed gene modules in blood neutrophils and in microglia of cognitively impaired female APOE ε4 carriers, showing increased infiltration to the AD brain. APOE4 female IL-17+neutrophils upregulated the immunosuppressive cytokines IL-10 and TGFβ and immune checkpoints, including LAG3 and PD-1, associated with accelerated immune aging. Deletion of APOE4in neutrophils reduced this immunosuppressive phenotype and restored the microglial response to neurodegeneration, limiting plaque pathology in AD mice. Mechanistically, IL-17F upregulated in APOE4 neutrophils interacts with microglial IL-17RA to suppress the induction of the neurodegenerative phenotype, and blocking this axis supported cognitive improvement in AD mice. These findings provide a translational basis to target IL-17F in APOE ε4 female carriers with cognitive impairment.

Published
2024
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31. sj-docx-1-mso-10.1177_20552173231165196 - Supplemental material for Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine

Author

Conway, Sarah, Saxena, Shrishti, Baecher-Allan, Clare, Krishnan, Rajesh, Houtchens, Maria, Glanz, Bonnie, Saraceno, Taylor J, Polgar-Turcsanyi, Mariann, Bose, Gauruv, Bakshi, Rohit, Bhattacharyya, Shamik, Galetta, Kristin, Kaplan, Tamara, Severson, Christopher, Singhal, Tarun, Stazzone, Lynn, Zurawski, Jonathan, Paul, Anu, Weiner, Howard L, Healy, Brian C, and Chitnis, Tanuja

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-mso-10.1177_20552173231165196 for Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine by Sarah Conway, Shrishti Saxena, Clare Baecher-Allan, Rajesh Krishnan, Maria Houtchens, Bonnie Glanz, Taylor J Saraceno, Mariann Polgar-Turcsanyi, Gauruv Bose, Rohit Bakshi, Shamik Bhattacharyya, Kristin Galetta, Tamara Kaplan, Christopher Severson, Tarun Singhal, Lynn Stazzone, Jonathan Zurawski, Anu Paul, Howard L Weiner, Brian C Healy and Tanuja Chitnis in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Published
2023
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32. sj-docx-2-mso-10.1177_20552173231165196 - Supplemental material for Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine

Author

Conway, Sarah, Saxena, Shrishti, Baecher-Allan, Clare, Krishnan, Rajesh, Houtchens, Maria, Glanz, Bonnie, Saraceno, Taylor J, Polgar-Turcsanyi, Mariann, Bose, Gauruv, Bakshi, Rohit, Bhattacharyya, Shamik, Galetta, Kristin, Kaplan, Tamara, Severson, Christopher, Singhal, Tarun, Stazzone, Lynn, Zurawski, Jonathan, Paul, Anu, Weiner, Howard L, Healy, Brian C, and Chitnis, Tanuja

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-2-mso-10.1177_20552173231165196 for Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine by Sarah Conway, Shrishti Saxena, Clare Baecher-Allan, Rajesh Krishnan, Maria Houtchens, Bonnie Glanz, Taylor J Saraceno, Mariann Polgar-Turcsanyi, Gauruv Bose, Rohit Bakshi, Shamik Bhattacharyya, Kristin Galetta, Tamara Kaplan, Christopher Severson, Tarun Singhal, Lynn Stazzone, Jonathan Zurawski, Anu Paul, Howard L Weiner, Brian C Healy and Tanuja Chitnis in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Published
2023
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36. Vγ1 and Vγ4 γδ T cell subsets play opposing roles in traumatic brain injury

Author

Weiner, Howard, primary, Abou-El-Hassan, Hadi, additional, Rezende, Rafael, additional, Gabriely, Galina, additional, Tatematsu, Bruna, additional, Habashy, Karl, additional, Lopes, Juliana, additional, Maghzi, Hadi, additional, Izzy, Saef, additional, Yahya, Taha, additional, Yin, Zhuoran, additional, Krishnan, Rajesh, additional, and Butovsky, Oleg, additional

Published
2022
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37. Intellectual Property [An open letter to Prime Minister Narendra Modi.]

Author

Bhutani, Shalini, Das, B L, Grover, Anand, Gopakumar, K M, Abrol, Dinesh, Ghosh, Jayati, Menon-Sen, Kalyani, Srinivasan, S, Sengupta, Amit, Shiva, Mira, Dhar, Biswajit, Ramdas, Sagari R, Dora, K Pandu, Kuruganti, Kavitha, Ahuja, Vikas, Gangte, Loon, Rodrigues, Aruna, Sahai, Suman, Dcosta, Wilfred, Mazumdar, Surajit, Kohli, Kanchi, Shah, Kapil, Ashalatha, S, Panjabi, Kavita, Dutt, Umendra, Usha, S, Burte, Aruna, Menon, Nivedita, Dietrich, Gabriele, Raman, Kannamma, Nellithanam, Jacob, Krishnan, Rajesh, Arora, Rachna, Gupta, Ashish, Alvares, Claude, Baiju, M R, Sarin, Madhu, Satheesh, P V, Kumar, C N Suresh, Jayasri, C, Babu, A Giridhar, Masanagari, Narsamma, Mansata, Bharat, James, T C, Reddy, D Narasimha, Choudhary, Mishi, Rao, K Ashok, Ekbal, B, Mody, Gautam, Abraham, Sunil, Johari, Veena, Arunachalam, Subbiah, Shiva, Vandana, Pardeshi, Manoj, Aisola, Malini, and Jafri, Afsar H

Published
2014

38. Positive trends in paediatric renal biopsy service provision in the UK: a national survey and re-audit of paediatric renal biopsy practice

Author

Gupta, Asheeta, Campion-Smith, Joanna, Hayes, Wesley, Deal, Jane E., Gilbert, Rodney D., Inward, Carole, Judd, Brian A., Krishnan, Rajesh G., Marks, Stephen D., O'Brien, Catherine, Shenoy, Mohan, Sinha, Manish D., Tse, Yincent, Tyerman, Kay, Mallik, Meeta, and Hussain, Farida

Subjects
Kidney biopsy -- Research -- Health aspects, Health
Abstract

Background Paediatric renal biopsy standards introduced in the UK in 2010 were intended to reduce variation and improve practice. A concurrent national drive was aimed at building robust paediatric nephrology networks to ensure services cater for the needs of the family and minimise time away from home. We aimed to identify current national practice since these changes on behalf of the British Association for Paediatric Nephrology. Methods All UK paediatric nephrology centres were invited to complete a survey of their biopsy practice, including advance preparation. From 1 January to 30 June 2012, a national prospective audit of renal biopsies was undertaken at participating centres comparing practice with the British Association for Paediatric Nephrology (BAPN) standards and audit results from 2005. Results Survey results from 11 centres demonstrated increased use of pre-procedure information leaflets (63.6 % vs 45.5 %, P = 0.39) and play preparation (90.9 % vs 9.1 %, P = 0.0001). Audit of 331 biopsies showed a move towards day-case procedures (49.5 % vs 32.9 %, P = 0.17) and reduced major complications (4.5 % vs 10.4 %, P = 0.002). Biopsies with 18-gauge needles had significantly higher mean pass rates (3.2 vs 2.3, P = 0.0008) and major complications (15.3 % vs 3.3 %, P = 0.0015) compared with 16-gauge needles. Conclusions Percutaneous renal biopsy remains a safe procedure in children, thus improving family-centered service provision in the UK., Author(s): Asheeta Gupta[sup.1] , Joanna Campion-Smith[sup.2] , Wesley Hayes[sup.3] , Jane E. Deal[sup.4] , Rodney D. Gilbert[sup.5] , Carole Inward[sup.3] , Brian A. Judd[sup.6] , Rajesh G. Krishnan[sup.7] , Stephen [...]

Published
2016
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46. When is biopsy-proven TIN not simply TIN? Answers

Author

Ware, Nicholas, Sebire, Neil J., Chong, W. K., Krishnan, Rajesh, and Marks, Stephen D.

Subjects
Health
Abstract

Author(s): Nicholas Ware [sup.1] , Neil J. Sebire [sup.1] , W. K. Chong [sup.1] , Rajesh Krishnan [sup.2] , Stephen D. Marks [sup.1] Author Affiliations: (1) 0000 0004 0426 7394grid.424537.3Department [...]

Published
2017
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