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6 results on '"Krishnan Abinaya"'

1. Valorization of surplus onion for the development and characterization of antioxidant-rich gummies

Author

Krishnan Abinaya, Kumar Sharmila, Santhanvelayudham Priya, Marimuthu Ponmozhi, and Radhakrishnan Linekha

Subjects
Quercetin, Antioxidant, Food pharmacy, Confectionery, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Allium cepa is an herbaceous biennial plant cultivated for its edible bulb and the elementary ingredient in Indian cooking. The surplus onion presents a huge loss due to drying rotting, sprouting, fungal damage, etc. Formulating an onion gummy is a rich source of antioxidants that can promote healthy living and prevent diseases. Our study developed an antioxidant-rich gummy using red onion transforming its pungent taste using tamarind. The gummy samples were subjected to physicochemical analysis where the pH of the samples was in the range of 5.64 to 5.51, the moisture and sugar content ranged from 59.6 to 57.9 and 60.97 to 59.10 respectively, the texture properties of the gummy jelly showed hardness in the range from 571.81±0.2 to 378.26±0.9 g, chewiness from 1,819.1 ± 64.22 to 1,390.9 ± 56.7 g, adhesiveness from 57.4 ± 1.33 to 58.6 ± 1.55, and springiness from 48.78±0.2 to 40.73±0.4 and finally the chromaticity values (L*, a*, and b*) of gummy jelly were, lightness in the range from 7.78±0.08 to 5.83±0.08, redness from 3.39±0.10 to 0.54±0.08 and yellowness from 1.65±0.05 to 1.27±0.05. The antioxidant activity was analyzed using DPPH and ABTS radical scavenging activity and was in the range of 29.75 to 78.85% and 18 to 62% respectively. The sensory evaluation showed that buying intention was highly ranked followed by appearance, taste, flavor, overall preference, and texture. In this study, we conclude that the antioxidant-rich red onion gummy jelly (ROGJ) developed with potential antioxidant activity can be commercialized and could be a healthy substitute for commercial unhealthy gummy jellies.

Published
2023
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3. The effect of social determinants of health on severity of microbial keratitis presentation at a tertiary eye care hospital in Southern India

Author

Annadanam, Anvesh, Hicks, Patrice, Lu, Ming-Chen, Pawar, Mercy, Kochar, Prabhleen, Selvaraj, Suvitha, Kuppuraj, Dhanya, Rathod, Chetan, Muppala, Rekha, Gaur, Smriti, Krishnan, Abinaya, Sumithra, S., Woodward, Maria, and Prajna, N.

Subjects
Eye infections -- Statistics -- Risk factors -- Demographic aspects, Keratitis -- Statistics -- Risk factors -- Demographic aspects, Health
Abstract

Byline: Anvesh. Annadanam, Patrice. Hicks, Ming-Chen. Lu, Mercy. Pawar, Prabhleen. Kochar, Suvitha. Selvaraj, Dhanya. Kuppuraj, Chetan. Rathod, Rekha. Muppala, Smriti. Gaur, Abinaya. Krishnan, S. Sumithra, Maria. Woodward, N. Prajna Purpose: [...]

Published
2023

4. GC-MS fingerprinting and in silico molecular interaction of antioxidant agents from A. malabarica as tyrosinase inhibitors

Author

Gnanaselvan Suvathika, Alagar Yadav Sangilimuthu, Manoharan Sowmya Priya, Arumugam Shanmugapriya, and Krishnan Abinaya

Subjects
Bioengineering, Applied Microbiology and Biotechnology, Biotechnology
Abstract

Free radicals are generated by the chemical reaction of oxidation and they set off chain reactions that damage cells. In this study, the antioxidant activity of Anisomeles malabarica methanolic leaves extract were examined by DPPH and ABTS radical scavenging assays (in vitro). Molecular docking (in silico) using SeeSAR-9.2 was performed to find out the possible antioxidant phytoconstituents that inhibit the tyrosinase receptor (3NM8) from A. malabarica. Physicochemical and ADMET properties of phytocompounds were evaluated using StarDrop software. About 6 phytoconstituents were identified from A. malabarica methanolic leaves extract by using GC-MS analysis. DPPH and ABTS free radical scavenging activities of leaves extract reveal dose dependent and IC50 values of 81.28 ± 0.02 and 81.49 ± 0.15 μg/ml and the standard L-ascorbic acid showed 52.19 ± 0.05 and 66.46 ± 0.23 μg/ml respectively. Molecular docking studies report that 2,5-ditert-butylphenol and phytol had stronger binding efficiency on tyrosinase enzyme. Physicochemical and ADMET analysis of phytocompounds showed that 2,5-ditert-butylphenol had higher druglikeness properties.

Published
2022

6. Mechanistic insights into the effect of CYP2C9*2 and CYP2C9*3 variants on the 7-hydroxylation of warfarin

Author

Addepalli Pavani, Krishnan Abinaya, Addepally Uma, Renganathan Gnanambal Kamakshi, Vijay Kumar Kutala, Balraj Alex Stanley, Malempati Amaresh Rao, and Shaik Mohammad Naushad

Subjects
Adult, Male, Genotype, In silico, Computational biology, Pharmacology, Hydroxylation, chemistry.chemical_compound, Pharmacokinetics, Linear regression, Genetics, medicine, Humans, heterocyclic compounds, cardiovascular diseases, CYP2C9, Cytochrome P-450 CYP2C9, Polymorphism, Genetic, biology, Hydrogen bond, Warfarin, Anticoagulants, Hydrogen Bonding, Middle Aged, CYP2C9*3, chemistry, biology.protein, Molecular Medicine, Female, medicine.drug
Abstract

Aim: To evaluate the impact of CYP2C9*2 and CYP2C9*3 variants on binding and hydroxylation of warfarin. Materials & methods: Multiple linear regression model of warfarin pharmacokinetics was developed from the dataset of patients (n = 199). Pymol based in silico models were developed for the genetic variants. Results: CYP2C9*2 and CYP2C9*3 variants exhibited high warfarin/7-hydroxywarfarin (multiple linear regression model), dose-dependent disruption of hydrogen bonds with warfarin, dose-dependent increase in the distance between C7 of S-warfarin and Fe–O of CYP2C9, dose-dependent decrease in the glide scores (in silico). Conclusion: CYP2C9*2 and CYP2C9*3 variants result in disruption of hydrogen bonding interactions with warfarin and longer distance between C7 and Fe–O thus impairing warfarin 7-hydroxylation due to lower binding affinity of warfarin. Original submitted 7 May 2014; Revision submitted 30 October 2014

Published
2015

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