1. Transgenic mouse model for the fragile X syndrome
- Author
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Guy Nagels, R. Frank Kooy, Kristel De Boulle, Gilbert Clincke, Rudi D'Hooge, Ben A. Oostra, Edwin Reyniers, Patrick Willems, Peter Paul De Deyn, Katrien Storm, and Cathy E. Bakker
- Subjects
Fragile X syndrome ,Genetically modified mouse ,Genetics ,Macroorchidism ,Transgene ,Knockout mouse ,medicine ,Gene mutation ,Biology ,medicine.disease ,FMR1 ,Genetics (clinical) ,Transgenic Model - Abstract
Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. Initial experiments suggested that the knockout mice show macroorchidism and cognitive and behavioral deficits, abnormalities comparable to those of human fragile X patients. In the present study, we have extended our experiments, and conclude that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome. 20 refs., 2 figs., 1 tab.
- Published
- 1996