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Anhand der 4. Universellen Definition des Myokardinfarkts (MI) wird dieses Krankheitsbild mit seinen zahlreichen ischamischen und nichtischamischen Ursachen klassifiziert. Ein akuter Myokardschaden ist durch einen signifikanten Anstieg der kardialen Troponine (cTn) gekennzeichnet. Bei zusatzlichem Vorliegen einer myokardialen Ischamie, die anhand von EKG-, klinischen, bildgebenden und angiographischen Kriterien definiert wird, kann die Diagnose eines akuten MI gestellt werden. Atiologisch lassen sich die MI in 5 Typen unterteilen (Typ 1: ischamisch durch Plaqueruptur oder Plaqueerosion mit Thrombenbildung, Typ 2: Missverhaltnis zwischen myokardialem Sauerstoffangebot und -bedarf, Typ 3: Post-mortem-Verdachtsdiagnose vor Moglichkeit einer cTn-Bestimmung, Typ 4a

The COVID-19 pandemic is placing a heavy burden on healthcare systems worldwide with the risk that acute cardiovascular diseases are treated too late. The present study aims to analyze patients with acute coronary syndrome in the current pandemic. A total of 966 patients (2019 n = 463, 2020 n = 503) can be evaluated. A comparison of patient care during and before the COVID-19 pandemic was made in terms of patient characteristics and pre- and in-hospital processes. Another aim is to show how many patients seek clinical care at a late stage of the disease. After Lockdown in Germany at week 12, 2020, there was a significant decrease in patients with an acute coronary syndrome (ACS), significant for STEMI cases in the first weeks after Lockdown (calendar week 13–16 2019 n = 43, 2020 n = 30; p = 0.02). The time from pain to first medical contact (time to FMC) is significantly extended during Lockdown, while internal clinical processes are unchanged. The rate of subacute myocardial infarction is numerically, but not significantly increased in calendar weeks 15, 2020 (p = 0.40) and 16 (p = 0,19). In addition, elderly patients avoid treatment for multifactorial reasons, and the longer overall pain to FMC may impact long-term mortality.

Background: The vascular access in transcatheter aortic valve replacement (TAVR) was initially dominated by a surgical approach. Meanwhile, percutaneous closure systems became a well-established alternative. The aim of this study was to compare the clinical outcome between the two approaches. Methods: In this retrospective study, we observed 787 patients undergoing a TAVR-Procedure between 2013 and 2019. Of those, 338 patients were treated with surgical access and 449 with the Perclose ProGlide™-System (Abbott, Chicago, IL, USA). According to the Bleeding Academic Research Consortium (BARC) and Valve Academic Research Consortium (VARC) criteria, the primary combined endpoints were defined. Results: Overall hospital mortality was 2.8% with no significant difference between surgical (3.8%) and percutaneous (2.2%) access (p = 0.182). Major vascular complications or bleeding defined as the primary combined endpoint was not significantly different in either group (Surgical group 5.3%, ProGlide group 5.1%, p = 0.899). In the ProGlide group, women with pre-existing peripheral artery disease (PAD) were significantly more often affected by a vascular complication (p = 0.001 for female sex and p = 0.03 for PAD). Conclusions: We were able to show that the use of both accesses is safe. However, the surgical access route should also be considered in case of peripheral artery disease.

This disease with its multiple ischemic and non-ischemic manifestations is classified based on the fourth universal definition of myocardial infarction (MI). An acute myocardial injury is defined as a significant increase of cardiac troponins (cTn). In patients with an additional myocardial ischemia, which is defined by certain clinical, electrocardiographic, imaging and angiographic criteria, the diagnosis of acute MI can be made. Etiologically, MI can be divided into 5 types: type 1 ischemic by plaque rupture or plaque erosion with thrombus formation, type 2 imbalance between myocardial oxygen demand and supply, type 3 MI as suspected cause of death before determination of cTn, type 4a48 h after percutaneous coronary intervention (PCI), type 4b stent thrombosis, type 4c in-stent stenosis and type 548 h after coronary artery bypass grafting (CABG). This classification reflects the heterogeneity of acute MI. Based on clearly defined criteria the guidelines attempt to provide clinically active physicians with assistance in the diagnosis and treatment of this specific disease. Nevertheless, it is still necessary to take a holistic view of the patient with all the individual characteristics.