Search

Your search keyword '"Krivitsky, Vadim"' showing total 27 results
Start Over Author "Krivitsky, Vadim"
27 results on '"Krivitsky, Vadim"'

3. Ultrafast and Controlled Capturing, Loading, and Release of Extracellular Vesicles by a Portable Microstructured Electrochemical Fluidic Device

Author

Krivitsky, Vadim, primary, Krivitsky, Adva, additional, Mantella, Valeria, additional, Ben‐Yehuda Greenwald, Maya, additional, Sankar, Devanarayanan Siva, additional, Betschmann, Jil, additional, Bader, Johannes, additional, Zoratto, Nicole, additional, Schreier, Kento, additional, Feiss, Sarah, additional, Walker, Dario, additional, Dengjel, Jörn, additional, Werner, Sabine, additional, and Leroux, Jean‐Christophe, additional

Published
2023
Full Text
View/download PDF

5. Sulfonated Amphiphilic Poly(α)glutamate Amine—A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors

Author

Krivitsky, Adva, primary, Pozzi, Sabina, additional, Yeini, Eilam, additional, Israeli Dangoor, Sahar, additional, Zur, Tal, additional, Golan, Sapir, additional, Krivitsky, Vadim, additional, Albeck, Nitzan, additional, Pisarevsky, Evgeny, additional, Ofek, Paula, additional, Madi, Asaf, additional, and Satchi-Fainaro, Ronit, additional

Published
2021
Full Text
View/download PDF

13. Additional file 1 of Real-time monitoring of bacterial biofilms metabolic activity by a redox-reactive nanosensors array

Author

Yeor-Davidi, Ella, Zverzhinetsky, Marina, Krivitsky, Vadim, and Patolsky, Fernando

Abstract

Additional file 1: (1) Characterization and calibration of the sensing system; (2) Synthesis of p-type silicon nanowires via chemical vapor deposition; (3) Fabrication of silicon nanowire field-effect-transistor array; (4) Electrical characterization of SiNW devices with the use of a water gate; (5) Scanning electron microscope analysis; (6) Surface modification; (7) Preparation of 9,10-anthraquinone-2-sulfochloride; (8) Surface modification of SiNW-FET array with 9,10-anthraquinone-2 sulfochloride; (9) Fabrication of the microfluidic channel as a delivery system; (10) Electrical measurements system of SiNW-FET devices; (11) E. coli culture handling; (12) Formation and maintenance of bacterial biofilms; (13) Measurement protocol; (14) Enzymes, cofactors, antibiotics, and metabolites used for metabolic analysis; (15) Error analysis.

Published
2020
Full Text
View/download PDF

15. Light-Controlled Selective Collection-and-Release of Biomolecules by an On-Chip Nanostructured Device

Author

Borberg, Ella, primary, Zverzhinetsky, Marina, additional, Krivitsky, Adva, additional, Kosloff, Alon, additional, Heifler, Omri, additional, Degabli, Gal, additional, Soroka, Hagit Peretz, additional, Fainaro, Ronit Satchi, additional, Burstein, Larisa, additional, Reuveni, Shlomi, additional, Diamant, Haim, additional, Krivitsky, Vadim, additional, and Patolsky, Fernando, additional

Published
2019
Full Text
View/download PDF

22. Light-Controlled Selective Collection-and-Release of Biomolecules by an On-Chip Nanostructured Device

Author

Borberg, Ella, Zverzhinetsky, Marina, Krivitsky, Adva, Kosloff, Alon, Heifler, Omri, Degabli, Gal, Soroka, Hagit Peretz, Fainaro, Ronit Satchi, Burstein, Larisa, Reuveni, Shlomi, Diamant, Haim, Krivitsky, Vadim, and Patolsky, Fernando

Abstract

The analysis of biosamples, e.g., blood, is a ubiquitous task of proteomics, genomics, and biosensing fields; yet, it still faces multiple challenges, one of the greatest being the selective separation and detection of target proteins from these complex biosamples. Here, we demonstrate the development of an on-chip light-triggered reusable nanostructured selective and quantitative protein separation and preconcentration platform for the direct analysis of complex biosamples. The on-chip selective separation of required protein analytes from raw biosamples is performed using antibody–photoacid-modified Si nanopillars vertical arrays (SiNPs) of ultralarge binding surface area and enormously high binding affinity, followed by the light-controlled rapid release of the tightly bound target proteins in a controlled liquid media. Two important experimental observations are presented: (1) the first demonstration on the control of biological reaction binding affinity by the nanostructuring of the capturing surface, leading to highly efficient protein collection capabilities, and (2) the light-triggered switching of the highly sticky binding surfaces into highly reflective nonbinding surfaces, leading to the rapid and quantitative release of the originally tightly bound protein species. Both of these two novel behaviors were theoretically and experimentally investigated. Importantly, this is the first demonstration of a three-dimensional (3D) SiNPs on-chip filter with ultralarge binding surface area and reversible light-controlled quantitative release of adsorbed biomolecules for direct purification of blood samples, able to selectively collect and separate specific low abundant proteins, while easily removing unwanted blood components (proteins, cells) and achieving desalting results, without the requirement of time-consuming centrifugation steps, the use of desalting membranes, or affinity columns.

Published
2024
Full Text
View/download PDF

24. Supersensitive fingerprinting of explosives by chemically modified nanosensors arrays

Author

Lichtenstein, Amir, primary, Havivi, Ehud, additional, Shacham, Ronen, additional, Hahamy, Ehud, additional, Leibovich, Ronit, additional, Pevzner, Alexander, additional, Krivitsky, Vadim, additional, Davivi, Guy, additional, Presman, Igor, additional, Elnathan, Roey, additional, Engel, Yoni, additional, Flaxer, Eli, additional, and Patolsky, Fernando, additional

Published
2014
Full Text
View/download PDF

26. Supersensitive fingerprinting of explosives by chemically modified nanosensors arrays

Author

Fernando Patolsky, Vadim Krivitsky, Guy Davivi, Igor Presman, Amir Lichtenstein, Ronen Shacham, Ronit Leibovich, Alexander Pevzner, Eli Flaxer, Ehud Hahamy, Roey Elnathan, Ehud Havivi, Yoni Engel, Lichtenstein, Amir, Havivi, Ehud, Shacham, Ronen, Hahamy, Ehud, Leibovich, Ronit, Pevzner, Alexander, Krivitsky, Vadim, Davivi, Guy, Presman, Igor, Elnathan, Roey, Engel, Yoni, Flaxer, Eli, and Patolsky, Fernando

Subjects
Remote detection, Multidisciplinary, Materials science, nanotechnology, Explosive material, detection method, General Physics and Astronomy, Nanotechnology, array, General Chemistry, explosive, tracer, Sensitivity (explosives), Rapid detection, General Biochemistry, Genetics and Molecular Biology, thermodynamics, sensor, Nanosensor, reaction kinetics
Abstract

The capability to detect traces of explosives sensitively, selectively and rapidly could be of great benefit for applications relating to civilian national security and military needs. Here, we show that, when chemically modified in a multiplexed mode, nanoelectrical devices arrays enable the supersensitive discriminative detection of explosive species. The fingerprinting of explosives is achieved by pattern recognizing the inherent kinetics, and thermodynamics, of interaction between the chemically modified nanosensors array and the molecular analytes under test. This platform allows for the rapid detection of explosives, from air collected samples, down to the parts-per-quadrillion concentration range, and represents the first nanotechnology-inspired demonstration on the selective supersensitive detection of explosives, including the nitro-and peroxide-derivatives, on a single electronic platform. Furthermore, the ultrahigh sensitivity displayed by our platform may allow the remote detection of various explosives, a task unachieved by existing detection technologies. Refereed/Peer-reviewed

Published
2014

27. Si nanowires forest-based on-chip biomolecular filtering, separation and preconcentration devices: nanowires do it all

Author

Vadim Krivitsky, Raisa Kantaev, Amir Lichtenstein, Fernando Patolsky, Roey Elnathan, Boris Brudnik, Alexander Pevzner, Artium Khatchtourints, Lo Chang Hsiung, Krivitsky, Vadim, Hsiung, Lo-Chang, Lichtenstein, Amir, Brudnik, Boris, Kantaev, Raisa, Elnathan, Roey, Pevzner, Alexander, Khatchtourints, Artium, and Patolsky, Fernando

Subjects
separation, Analyte, Silicon, Materials science, nanowire arrays, Nanowire, Ultrafiltration, Bioengineering, Nanotechnology, biomolecules, Materials Testing, preconcentration, General Materials Science, Particle Size, Silicon nanowires, Direct analysis, chemistry.chemical_classification, Mechanical Engineering, Biomolecule, General Chemistry, Blood Proteins, biosensors, Condensed Matter Physics, Nanostructures, filters, chemistry, Blood Component Removal, Adsorption, Biosensor, Porosity
Abstract

The development of efficient biomolecular separation and purification techniques is of critical importance in modern genomics, proteomics, and biosensing areas, primarily due to the fact that most biosamples are mixtures of high diversity and complexity. Most of existent techniques lack the capability to rapidly and selectively separate and concentrate specific target proteins from a complex biosample, and are difficult to integrate with lab-on-a-chip sensing devices. Here, we demonstrate the development of an on-chip all-SiNW filtering, selective separation, desalting, and preconcentration platform for the direct analysis of whole blood and other complex biosamples. The separation of required protein analytes from raw biosamples is first performed using a antibody-modified roughness-controlled SiNWs (silicon nanowires) forest of ultralarge binding surface area, followed by the release of target proteins in a controlled liquid media, and their subsequent detection by supersensitive SiNW-based FETs arrays fabricated on the same chip platform. Importantly, this is the first demonstration of an all-NWs device for the whole direct analysis of blood samples on a single chip, able to selectively collect and separate specific low abundant proteins, while easily removing unwanted blood components (proteins, cells) and achieving desalting effects, without the requirement of time-consuming centrifugation steps, the use of desalting or affinity columns. Futhermore, we have demonstrated the use of our nanowire forest-based separation device, integrated in a single platform with downstream SiNW-based sensors arrays, for the real-time ultrasensitive detection of protein biomarkers directly from blood samples. The whole ultrasensitive protein label-free analysis process can be practically performed in less than 10 min. Refereed/Peer-reviewed

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results