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1. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Author

Yammine, S. G., Huybrechts, I., Biessy, C., Dossus, L., Panico, S., Sánchez, M. J., Benetou, V., Turzanski-Fortner, R., Katzke, V., Idahl, A., Skeie, G., Olsen, K. Standahl, Tjønneland, A., Halkjaer, J., Colorado-Yohar, S., Heath, A. K., Sonestedt, E., Sartor, H., Schulze, M. B., Palli, D., Crous-Bou, M., Dorronsoro, A., Overvad, K., Gurrea, A. Barricarte, Severi, G., Vermeulen, R. C.H., Sandanger, T. M., Travis, R. C., Key, T., Amiano, P., Van Guelpen, B., Johansson, M., Sund, M., Tumino, R., Wareham, N., Sacerdote, C., Krogh, V., Brennan, P., Riboli, E., Weiderpass, E., Gunter, M. J., and Chajès, V.

Published
2023
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2. Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults

Author

Cordova, R., Knaze, V., Viallon, V., Rust, P., Schalkwijk, C. G., Weiderpass, E., Wagner, K-H., Mayen-Chacon, A-L., Aglago, E. K., Dahm, C. C., Overvad, K., Tjønneland, A., Halkjær, J., Mancini, F. R., Boutron-Ruault, M-C., Fagherazzi, G., Katzke, V., Kühn, T., Schulze, M. B., Boeing, H., Trichopoulou, A., Karakatsani, A., Thriskos, P., Masala, G., Krogh, V., Panico, S., Tumino, R., Ricceri, F., Spijkerman, A., Boer, J., Skeie, G., Rylander, C., Borch, K. B., Quirós, J. R., Agudo, A., Redondo-Sánchez, D., Amiano, P., Gómez-Gómez, J-H., Barricarte, A., Ramne, S., Sonestedt, E., Johansson, I., Esberg, A., Tong, T., Aune, D., Tsilidis, K. K., Gunter, M. J., Jenab, M., and Freisling, Heinz

Published
2020
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3. Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis

Author

Chadeau-Hyam, M, Vermeulen, RCH, Hebels, DGAJ, Castagné, R, Campanella, G, Portengen, L, Kelly, RS, Bergdahl, IA, Melin, B, Hallmans, G, Palli, D, Krogh, V, Tumino, R, Sacerdote, C, Panico, S, de Kok, TMCM, Smith, MT, Kleinjans, JCS, Vineis, P, Kyrtopoulos, SA, consortium, on behalf of the EnviroGenoMarkers project, Georgiadis, P, Botsivali, M, Papadopoulou, C, Chatziioannou, A, Valavanis, I, Gottschalk, R, van Leeuwen, D, Timmermans, L, Keun, HC, Athersuch, TJ, Lenner, P, Bendinelli, B, Stephanou, EG, Myridakis, A, Kogevinas, M, Saberi-Hosnijeh, F, Fazzo, L, de Santis, M, Comba, P, Kiviranta, H, Rantakokko, P, Airaksinen, R, Ruokojarvi, P, Gilthorpe, MS, Fleming, S, Fleming, T, Tu, Y-K, Jonsson, B, Lundh, T, Chien, K-L, Chen, WJ, Lee, W-C, Hsiao, CK, Kuo, P-H, Hung, H, and Liao, S-F

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Lymphatic Research, Lymphoma, Clinical Research, Orphan Drug, Genetics, Rare Diseases, Cancer, Hematology, 2.1 Biological and endogenous factors, Adult, Aged, Biomarkers, Tumor, Case-Control Studies, Female, Genome, Human, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Models, Genetic, Principal Component Analysis, Prospective Studies, Transcriptome, epidemiology, lymphoma, chronic lymphocytic leukemia, mRNA analyses, prospective cohort, EnviroGenoMarkers project consortium, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundB-cell lymphomas are a diverse group of hematological neoplasms with differential etiology and clinical trajectories. Increased insights in the etiology and the discovery of prediagnostic markers have the potential to improve the clinical course of these neoplasms.MethodsWe investigated in a prospective study global gene expression in peripheral blood mononuclear cells of 263 incident B-cell lymphoma cases, diagnosed between 1 and 17 years after blood sample collection, and 439 controls, nested within two European cohorts.ResultsOur analyses identified only transcriptomic markers for specific lymphoma subtypes; few markers of multiple myeloma (N = 3), and 745 differentially expressed genes in relation to future risk of chronic lymphocytic leukemia (CLL). The strongest of these associations were consistently found in both cohorts and were related to (B-) cell signaling networks and immune system regulation pathways. CLL markers exhibited very high predictive abilities of disease onset even in cases diagnosed more than 10 years after blood collection.ConclusionsThis is the first investigation on blood cell global gene expression and future risk of B-cell lymphomas. We mainly identified genes in relation to future risk of CLL that are involved in biological pathways, which appear to be mechanistically involved in CLL pathogenesis. Many but not all of the top hits we identified have been reported previously in studies based on tumor tissues, therefore suggesting that a mixture of preclinical and early disease markers can be detected several years before CLL clinical diagnosis.

Published
2014

5. Sex differences in food choices, adherence to dietary recommendations and plasma lipid profile in type 2 diabetes – The TOSCA.IT study

Author

Vitale, M., Masulli, M., Cocozza, S., Anichini, R., Babini, A.C., Boemi, M., Bonora, E., Buzzetti, R., Carpinteri, R., Caselli, C., Ceccarelli, E., Cignarelli, M., Citro, G., Clemente, G., Consoli, A., Corsi, L., De Gregorio, A., Di Bartolo, P., Di Cianni, G., Fontana, L., Garofolo, M., Giorda, C.B., Giordano, C., Grioni, S., Iovine, C., Longhitano, S., Mancastroppa, G., Mazzucchelli, C., Montani, V., Mori, M., Perriello, G., Rinaldi, M.E., Ruffo, M.C., Salvi, L., Sartore, G., Scaranna, C., Tonutti, L., Zamboni, C., Zogheri, A., Krogh, V., Cappellini, F., Signorini, S., Riccardi, G., and Vaccaro, O.

Published
2016
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6. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Author

Yammine, S G, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, M J, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, K Standahl, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, A K, Sonestedt, E, Sartor, H, Schulze, M B, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, A Barricarte, Severi, G, Vermeulen, R C H, Sandanger, T M, Travis, R C, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, M J, Chajès, V, Yammine, S G, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, M J, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, K Standahl, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, A K, Sonestedt, E, Sartor, H, Schulze, M B, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, A Barricarte, Severi, G, Vermeulen, R C H, Sandanger, T M, Travis, R C, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, M J, and Chajès, V

Published
2023

7. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Author

Yammine, S.G., Huybrechts, I., Biessy, C., Dossus, L., Panico, S., Sánchez, M.J., Benetou, V., Turzanski-Fortner, R., Katzke, V., Idahl, Annika, Skeie, G., Olsen, K. Standahl, Tjønneland, A., Halkjaer, J., Colorado-Yohar, S., Heath, A.K., Sonestedt, E., Sartor, H., Schulze, M.B., Palli, D., Crous-Bou, M., Dorronsoro, A., Overvad, K., Gurrea, A. Barricarte, Severi, G., Vermeulen, R.C.H., Sandanger, T.M., Travis, R.C., Key, T., Amiano, P., van Guelpen, Bethany, Johansson, M., Sund, Malin, Tumino, R., Wareham, N., Sacerdote, C., Krogh, V., Brennan, P., Riboli, E., Weiderpass, E., Gunter, M.J., Chajès, V., Yammine, S.G., Huybrechts, I., Biessy, C., Dossus, L., Panico, S., Sánchez, M.J., Benetou, V., Turzanski-Fortner, R., Katzke, V., Idahl, Annika, Skeie, G., Olsen, K. Standahl, Tjønneland, A., Halkjaer, J., Colorado-Yohar, S., Heath, A.K., Sonestedt, E., Sartor, H., Schulze, M.B., Palli, D., Crous-Bou, M., Dorronsoro, A., Overvad, K., Gurrea, A. Barricarte, Severi, G., Vermeulen, R.C.H., Sandanger, T.M., Travis, R.C., Key, T., Amiano, P., van Guelpen, Bethany, Johansson, M., Sund, Malin, Tumino, R., Wareham, N., Sacerdote, C., Krogh, V., Brennan, P., Riboli, E., Weiderpass, E., Gunter, M.J., and Chajès, V.

Published
2023
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8. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Author

Yammine, S.G. Huybrechts, I. Biessy, C. Dossus, L. Panico, S. Sánchez, M.J. Benetou, V. Turzanski-Fortner, R. Katzke, V. Idahl, A. Skeie, G. Olsen, K.S. Tjønneland, A. Halkjaer, J. Colorado-Yohar, S. Heath, A.K. Sonestedt, E. Sartor, H. Schulze, M.B. Palli, D. Crous-Bou, M. Dorronsoro, A. Overvad, K. Gurrea, A.B. Severi, G. Vermeulen, R.C.H. Sandanger, T.M. Travis, R.C. Key, T. Amiano, P. Van Guelpen, B. Johansson, M. Sund, M. Tumino, R. Wareham, N. Sacerdote, C. Krogh, V. Brennan, P. Riboli, E. Weiderpass, E. Gunter, M.J. Chajès, V. and Yammine, S.G. Huybrechts, I. Biessy, C. Dossus, L. Panico, S. Sánchez, M.J. Benetou, V. Turzanski-Fortner, R. Katzke, V. Idahl, A. Skeie, G. Olsen, K.S. Tjønneland, A. Halkjaer, J. Colorado-Yohar, S. Heath, A.K. Sonestedt, E. Sartor, H. Schulze, M.B. Palli, D. Crous-Bou, M. Dorronsoro, A. Overvad, K. Gurrea, A.B. Severi, G. Vermeulen, R.C.H. Sandanger, T.M. Travis, R.C. Key, T. Amiano, P. Van Guelpen, B. Johansson, M. Sund, M. Tumino, R. Wareham, N. Sacerdote, C. Krogh, V. Brennan, P. Riboli, E. Weiderpass, E. Gunter, M.J. Chajès, V.

Published
2023

9. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Author

IRAS OH Epidemiology Chemical Agents, Yammine, S G, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, M J, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, K Standahl, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, A K, Sonestedt, E, Sartor, H, Schulze, M B, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, A Barricarte, Severi, G, Vermeulen, R C H, Sandanger, T M, Travis, R C, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, M J, Chajès, V, IRAS OH Epidemiology Chemical Agents, Yammine, S G, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, M J, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, K Standahl, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, A K, Sonestedt, E, Sartor, H, Schulze, M B, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, A Barricarte, Severi, G, Vermeulen, R C H, Sandanger, T M, Travis, R C, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, M J, and Chajès, V

Published
2023

13. Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis

Author

Georgiadis, P., Botsivali, M., Papadopoulou, C., Chatziioannou, A., Valavanis, I., Gottschalk, R., van Leeuwen, D., Timmermans, L., Keun, H.C., Athersuch, T.J., Lenner, P., Bendinelli, B., Stephanou, E.G., Myridakis, A., Kogevinas, M., Saberi-Hosnijeh, F., Fazzo, L., de Santis, M., Comba, P., Kiviranta, H., Rantakokko, P., Airaksinen, R., Ruokojarvi, P., Gilthorpe, M.S., Fleming, S., Fleming, T., Tu, Y.-K., Jonsson, B., Lundh, T., Chien, K.-L., Chen, W.J., Lee, W.-C., Hsiao, C.K., Kuo, P.-H., Hung, H., Liao, S.-F., Chadeau-Hyam, M., Vermeulen, R.C.H., Hebels, D.G.A.J., Castagné, R., Campanella, G., Portengen, L., Kelly, R.S., Bergdahl, I.A., Melin, B., Hallmans, G., Palli, D., Krogh, V., Tumino, R., Sacerdote, C., Panico, S., de Kok, T.M.C.M., Smith, M.T., Kleinjans, J.C.S., Vineis, P., and Kyrtopoulos, S.A.

Published
2014
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16. Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: a cross-sectional study within the EPIC cohort

Author

Rinaldi, S., Kaaks, R., Friedenreich, C. M., Key, T. J., Travis, R., Biessy, C., Slimani, N., Overvad, K., Østergaard, J. N., Tjønneland, A., Olsen, A., Mesrine, S., Fournier, A., Dossus, L., Lukanova, A., Johnson, T., Boeing, H., Vigl, M., Trichopoulou, A., Benetou, V., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Ricceri, F., Panico, S., Bueno-de-Mesquita, H. B., Monninkhof, E. M., May, A. M., Weiderpass, E., Quirós, J. R., Travier, N., Molina-Montes, E., Amiano, P., Huerta, J. M., Ardanaz, E., Sund, M., Johansson, M., Khaw, K. T., Wareham, N., Scalbert, A., Gunter, M. J., Riboli, E., and Romieu, I.

Published
2014

17. Flavonoid and lignan intake in a mediterranean population: proposal for a holistic approach in polyphenol dietary analysis, the Moli-sani study

Author

Pounis, G., Castelnuovo, A. Di, Bonaccio, M., Costanzo, S., Persichillo, M., Krogh, V., Donati, M.B., de Gaetano, G., and Iacoviello, L.

Subjects
Health aspects, Flavonoids -- Health aspects, Lignin -- Health aspects, Polyphenols -- Health aspects
Abstract

INTRODUCTION According to a crude chemical definition, polyphenols are secondary metabolites of plants and are generally involved in the defense against ultraviolet radiation or aggression by pathogens. (1) Dietary polyphenols [...], BACKGROUND/OBJECTIVES: The objective of this study is to extract and assess data on the dietary intake of flavonoids and lignans in a healthy free-living Mediterranean population, using newly updated harmonized European Union food composition data. This work also aimed at analyzing in a holistic way the total content of the diet in major classes of polyphenols. SUBJECTS/METHODS: Six thousand nine hundred and eighty-one men and 7 048 women (aged [greater than or equal to] 35years) of the Moli-sani cohort, randomly recruited from the general population, were analyzed. The European Prospective Investigation into Cancer (EPIC) and Nutrition-Food Frequency Questionnaire was used for dietary assessment. The polyphenol content of each food group was evaluated using Eurofir BioActive Substances in Food Information System and the United States Department of Agriculture food composition tables (FCTs), when data were missing. Flavonol, flavone, flavanone, flavanol, anthocyanin, isoflavone and lignan intakes were calculated and polyphenol antioxidant content (PAC) score (-28, 28) constructed, to assess the total content of the diet in these nutrients. RESULTS: Seasonal and citrus fruits, leafy, grain, pod and root vegetables, and onions and garlic accounted for different proportions (11-70%) of the total intake of different polyphenols. Within the Moli-sani population, men or older, or no/former smokers, or physically active or obese/overweight individuals presented higher consumption of flavonoids, lignans and PAC score (P for all < 0.01). Multiple regression analysis showed that PAC score and its seven components were positively associated with Mediterranean diet (MeD) adherence in both genders ([beta]-coefficient >0, P < 0.001). In addition, 1 unit increase in PAC score was associated with 7.1-7.8% increase in the likelihood of high MeD adherence (P < 0.001). CONCLUSIONS: The intake of flavonoids and lignans in an European Union population was calculated using harmonized European Union FCT data. In addition, a holistic approach in dietary analysis of polyphenol intake was proposed. European Journal of Clinical Nutrition (2016) 70, 338-345; doi: 10.1038/ejcn.2015.178; published online 4 November 2015

Published
2016
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20. Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project

Author

González, C.A., Megraud, F., Buissonniere, A., Lujan Barroso, L., Agudo, A., Duell, E.J., Boutron-Ruault, M.C., Clavel-Chapelon, F., Palli, D., Krogh, V., Mattiello, A., Tumino, R., Sacerdote, C., Quirós, J.R., Sanchez-Cantalejo, E., Navarro, C., Barricarte, A., Dorronsoro, M., Khaw, K.-T., Wareham, N., Allen, N.E., Tsilidis, K.K., Bas Bueno-de-Mesquita, H., Jeurnink, S.M., Numans, M.E., Peeters, P.H.M., Lagiou, P., Valanou, E., Trichopoulou, A., Kaaks, R., Lukanova-McGregor, A., Bergman, M.M., Boeing, H., Manjer, J., Lindkvist, B., Stenling, R., Hallmans, G., Mortensen, L.M., Overvad, K., Olsen, A., Tjonneland, A., Bakken, K., Dumeaux, V., Lund, E., Jenab, M., Romieu, I., Michaud, D., Mouw, T., Carneiro, F., Fenge, C., and Riboli, E.

Published
2012
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23. Milk intake and incident stroke and coronary heart disease in populations of European descent : a mendelian randomization study

Author

Vissers, L.E.T., Sluijs, I., Burgess, S., Forouhi, N.G., Freisling, H., Imamura, F., Nilsson, Torbjörn K., Renström, Frida, Weiderpass, E., Aleksandrova, K., Dahm, C.C., Perez-Cornago, A., Schulze, M.B., Tong, T.Y.N., Aune, D., Bonet, C., Boer, J.M.A., Boeing, H., Chirlaque, M.D., Conchi, M.I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M.J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W.M.M., Riboli, E., Wareham, N.J., Danesh, J., Butterworth, A.S., Van Der Schouw, Y.T., Vissers, L.E.T., Sluijs, I., Burgess, S., Forouhi, N.G., Freisling, H., Imamura, F., Nilsson, Torbjörn K., Renström, Frida, Weiderpass, E., Aleksandrova, K., Dahm, C.C., Perez-Cornago, A., Schulze, M.B., Tong, T.Y.N., Aune, D., Bonet, C., Boer, J.M.A., Boeing, H., Chirlaque, M.D., Conchi, M.I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M.J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W.M.M., Riboli, E., Wareham, N.J., Danesh, J., Butterworth, A.S., and Van Der Schouw, Y.T.

Abstract

MEGASTROKE

Published
2022
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24. Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization

Author

Dam, V. Onland-Moret, N.C. Burgess, S. Chirlaque, M.-D. Peters, S.A.E. Schuit, E. Tikk, K. Weiderpass, E. Oliver-Williams, C. Wood, A.M. Tjønneland, A. Dahm, C.C. Overvad, K. Boutron-Ruault, M.-C. Schulze, M.B. Trichopoulou, A. Ferrari, P. Masala, G. Krogh, V. Tumino, R. Matullo, G. Panico, S. Boer, J.M.A. Verschuren, W.M.M. Waaseth, M. PCrossed D sign©rez, M.J.S. Amiano, P. Imaz, L. Moreno-Iribas, C. Melander, O. Harlid, S. Nordendahl, M. Wennberg, P. Key, T.J. Riboli, E. Santiuste, C. Kaaks, R. Katzke, V. Langenberg, C. Wareham, N.J. Schunkert, H. Erdmann, J. Willenborg, C. Hengstenberg, C. Kleber, M.E. Delgado, G. März, W. Kanoni, S. Dedoussis, G. Deloukas, P. Nikpay, M. Mcpherson, R. Scholz, M. Teren, A. Butterworth, A.S. Van Der Schouw, Y.T. and Dam, V. Onland-Moret, N.C. Burgess, S. Chirlaque, M.-D. Peters, S.A.E. Schuit, E. Tikk, K. Weiderpass, E. Oliver-Williams, C. Wood, A.M. Tjønneland, A. Dahm, C.C. Overvad, K. Boutron-Ruault, M.-C. Schulze, M.B. Trichopoulou, A. Ferrari, P. Masala, G. Krogh, V. Tumino, R. Matullo, G. Panico, S. Boer, J.M.A. Verschuren, W.M.M. Waaseth, M. PCrossed D sign©rez, M.J.S. Amiano, P. Imaz, L. Moreno-Iribas, C. Melander, O. Harlid, S. Nordendahl, M. Wennberg, P. Key, T.J. Riboli, E. Santiuste, C. Kaaks, R. Katzke, V. Langenberg, C. Wareham, N.J. Schunkert, H. Erdmann, J. Willenborg, C. Hengstenberg, C. Kleber, M.E. Delgado, G. März, W. Kanoni, S. Dedoussis, G. Deloukas, P. Nikpay, M. Mcpherson, R. Scholz, M. Teren, A. Butterworth, A.S. Van Der Schouw, Y.T.

Abstract

Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men. © 2022 The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

Published
2022

25. Milk intake and incident stroke and coronary heart disease in populations of European descent:A Mendelian Randomization study

Author

Vissers, L. E.T., Sluijs, I., Burgess, S., Forouhi, N. G., Freisling, H., Imamura, F., Nilsson, T. K., Renström, F., Weiderpass, E., Aleksandrova, K., Dahm, C. C., Perez-Cornago, A., Schulze, M. B., Tong, T. Y.N., Aune, D., Bonet, C., Boer, J. M.A., Boeing, H., Chirlaque, M. D., Conchi, M. I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M. J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W. M.M., Riboli, E., Wareham, N. J., Danesh, J., Butterworth, A. S., Van Der Schouw, Y. T., Vissers, L. E.T., Sluijs, I., Burgess, S., Forouhi, N. G., Freisling, H., Imamura, F., Nilsson, T. K., Renström, F., Weiderpass, E., Aleksandrova, K., Dahm, C. C., Perez-Cornago, A., Schulze, M. B., Tong, T. Y.N., Aune, D., Bonet, C., Boer, J. M.A., Boeing, H., Chirlaque, M. D., Conchi, M. I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M. J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W. M.M., Riboli, E., Wareham, N. J., Danesh, J., Butterworth, A. S., and Van Der Schouw, Y. T.

Published
2022

26. Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies

Author

Dugue, P-A, Bodelon, C, Chung, FF, Brewer, HR, Ambatipudi, S, Sampson, JN, Cuenin, C, Chajes, V, Romieu, I, Fiorito, G, Sacerdote, C, Krogh, V, Panico, S, Tumino, R, Vineis, P, Polidoro, S, Baglietto, L, English, D, Severi, G, Giles, GG, Milne, RL, Herceg, Z, Garcia-Closas, M, Flanagan, JM, Southey, MC, Dugue, P-A, Bodelon, C, Chung, FF, Brewer, HR, Ambatipudi, S, Sampson, JN, Cuenin, C, Chajes, V, Romieu, I, Fiorito, G, Sacerdote, C, Krogh, V, Panico, S, Tumino, R, Vineis, P, Polidoro, S, Baglietto, L, English, D, Severi, G, Giles, GG, Milne, RL, Herceg, Z, Garcia-Closas, M, Flanagan, JM, and Southey, MC

Abstract

BACKGROUND: DNA methylation in blood may reflect adverse exposures accumulated over the lifetime and could therefore provide potential improvements in the prediction of cancer risk. A substantial body of research has shown associations between epigenetic aging and risk of disease, including cancer. Here we aimed to study epigenetic measures of aging and lifestyle-related factors in association with risk of breast cancer. METHODS: Using data from four prospective case-control studies nested in three cohorts of European ancestry participants, including a total of 1,655 breast cancer cases, we calculated three methylation-based measures of lifestyle factors (body mass index [BMI], tobacco smoking and alcohol consumption) and seven measures of epigenetic aging (Horvath-based, Hannum-based, PhenoAge and GrimAge). All measures were regression-adjusted for their respective risk factors and expressed per standard deviation (SD). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional or unconditional logistic regression and pooled using fixed-effects meta-analysis. Subgroup analyses were conducted by age at blood draw, time from blood sample to diagnosis, oestrogen receptor-positivity status and tumour stage. RESULTS: None of the measures of epigenetic aging were associated with risk of breast cancer in the pooled analysis: Horvath 'age acceleration' (AA): OR per SD = 1.02, 95%CI: 0.95-1.10; AA-Hannum: OR = 1.03, 95%CI:0.95-1.12; PhenoAge: OR = 1.01, 95%CI: 0.94-1.09 and GrimAge: OR = 1.03, 95%CI: 0.94-1.12, in models adjusting for white blood cell proportions, body mass index, smoking and alcohol consumption. The BMI-adjusted predictor of BMI was associated with breast cancer risk, OR per SD = 1.09, 95%CI: 1.01-1.17. The results for the alcohol and smoking methylation-based predictors were consistent with a null association. Risk did not appear to substantially vary by age at blood draw, time to diagnosis or tumour characteristics. CONCLUSION

Published
2022

27. Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking

Author

Petrovic, D, Bodinier, B, Dagnino, S, Whitaker, M, Karimi, M, Campanella, G, Haugdahl Nost, T, Polidoro, S, Palli, D, Krogh, V, Tumino, R, Sacerdote, C, Panico, S, Lund, E, Dugue, P-A, Giles, GG, Severi, G, Southey, M, Vineis, P, Stringhini, S, Bochud, M, Sandanger, TM, Vermeulen, RCH, Guida, F, Chadeau-Hyam, M, Petrovic, D, Bodinier, B, Dagnino, S, Whitaker, M, Karimi, M, Campanella, G, Haugdahl Nost, T, Polidoro, S, Palli, D, Krogh, V, Tumino, R, Sacerdote, C, Panico, S, Lund, E, Dugue, P-A, Giles, GG, Severi, G, Southey, M, Vineis, P, Stringhini, S, Bochud, M, Sandanger, TM, Vermeulen, RCH, Guida, F, and Chadeau-Hyam, M

Abstract

Smoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung cancer and explored the role of smoking in these associations. We analysed CpGs in relation to lung cancer in participants from two nested case-control studies, using (LASSO)-penalised regression. We accounted for the effects of smoking using known smoking-related CpGs, and through conditional-independence network. We identified 29 CpGs (8 smoking-related, 21 smoking-unrelated) associated with lung cancer. Models additionally adjusted for Comprehensive Smoking Index-(CSI) selected 1 smoking-related and 49 smoking-unrelated CpGs. Selected CpGs yielded excellent discriminatory performances, outperforming information provided by CSI only. Of the 8 selected smoking-related CpGs, two captured lung cancer-relevant effects of smoking that were missed by CSI. Further, the 50 CpGs identified in the CSI-adjusted model complementarily explained lung cancer risk. These markers may provide further insight into lung cancer carcinogenesis and help improving early identification of high-risk patients.

Published
2022

28. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Author

Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), Järvelin, M.-R. (Marjo-Riitta), Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), and Järvelin, M.-R. (Marjo-Riitta)

Abstract

We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.

Published
2022

29. Milk intake and incident stroke and CHD in populations of European descent: A Mendelian randomisation study

Author

Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Public Health Practice, Public Health Epidemiologie, Vissers, L. E.T., Sluijs, I., Burgess, S., Forouhi, N. G., Freisling, H., Imamura, F., Nilsson, T. K., Renström, F., Weiderpass, E., Aleksandrova, K., Dahm, C. C., Perez-Cornago, A., Schulze, M. B., Tong, T. Y.N., Aune, D., Bonet, C., Boeing, H., Chirlaque, M. D., Conchi, M. I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M. J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W. M.M., Riboli, E., Wareham, N. J., Danesh, J., Butterworth, A. S., Van Der Schouw, Y. T., Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Public Health Practice, Public Health Epidemiologie, Vissers, L. E.T., Sluijs, I., Burgess, S., Forouhi, N. G., Freisling, H., Imamura, F., Nilsson, T. K., Renström, F., Weiderpass, E., Aleksandrova, K., Dahm, C. C., Perez-Cornago, A., Schulze, M. B., Tong, T. Y.N., Aune, D., Bonet, C., Boeing, H., Chirlaque, M. D., Conchi, M. I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M. J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W. M.M., Riboli, E., Wareham, N. J., Danesh, J., Butterworth, A. S., and Van Der Schouw, Y. T.

Published
2022

30. Meat Intake and Bladder Cancer in a Prospective Study: A Role for Heterocyclic Aromatic Amines?

Author

Lumbreras, B., Garte, S., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Linseisen, J. P., Boeing, H., Trichopoulou, A., Palli, D., Peluso, M., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H. B., Peeters, P. H., Lund, E., Martinez, C., Dorronsoro, M., Barricarte, A., Chirlaque, M.-D., Quiros, J. R., Berglund, G., Hallmans, G., Day, N. E., Key, T. J., Saracci, R., Kaaks, R., Malaveille, C., Ferrari, P., Boffetta, P., Norat, T., Riboli, E., Gonzalez, C. A., and Vineis, P.

Published
2008
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31. Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study

Author

Mariosa, D, Smith-Byrne, K, Richardson, TG, Ferrari, P, Gunter, MJ, Papadimitriou, N, Murphy, N, Christakoudi, S, Tsilidis, KK, Riboli, E, Muller, D, Purdue, MP, Chanock, SJ, Hung, RJ, Amos, CI, O'Mara, TA, Amiano, P, Pasanisi, F, Rodriguez-Barranco, M, Krogh, V, Tjønneland, A, Halkjær, J, Perez-Cornago, A, Chirlaque, M-D, Skeie, G, Rylander, C, Borch, KB, Aune, D, Heath, AK, Ward, HA, Schulze, M, Bonet, C, Weiderpass, E, Smith, GD, Brennan, P, Johansson, M, Mariosa, Daniela, Smith-Byrne, Karl, Richardson, Tom G, Ferrari, Pietro, Gunter, Marc J, Papadimitriou, Niko, Murphy, Neil, Christakoudi, Sofia, Tsilidis, Konstantinos K, Riboli, Elio, Muller, David, Purdue, Mark P, Chanock, Stephen J, Hung, Rayjean J, Amos, Christopher I, O'Mara, Tracy A, Amiano, Pilar, Pasanisi, Fabrizio, Rodriguez-Barranco, Miguel, Krogh, Vittorio, Tjønneland, Anne, Halkjær, Jytte, Perez-Cornago, Aurora, Chirlaque, María-Dolore, Skeie, Guri, Rylander, Charlotta, Borch, Kristin Benjaminsen, Aune, Dagfinn, Heath, Alicia K, Ward, Heather A, Schulze, Matthia, Bonet, Catalina, Weiderpass, Elisabete, Smith, George Davey, Brennan, Paul, and Johansson, Mattias

Subjects
Adult, SUSCEPTIBILITY LOCI, Epidemiology, OVARIAN-CANCER, Body Mass Index, 1117 Public Health and Health Services, POOLED ANALYSIS, Cohort Studies, MASS INDEX, Neoplasms, Body Size, Humans, Obesity, Prospective Studies, Genetics & Heredity, LIFE-COURSE, 0604 Genetics, Science & Technology, IDENTIFICATION, ENDOMETRIAL CANCER, Mendelian Randomization Analysis, Oncology, ADIPOSITY, Mathematical & Computational Biology, Life Sciences & Biomedicine, ANTHROPOMETRIC FACTORS, Genome-Wide Association Study
Abstract

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23-2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09-1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.

Published
2022
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32. Country-specific dietary patterns and associations with socioeconomic status in European children: the IDEFICS study

Author

Fernandez-Alvira, J.M., Bammann, K., Pala, V., Krogh, V., Barba, G., Eiben, G., Hebestreit, A., Veidebaum, T., Reisch, L., Tornaritis, M., Kovacs, E., Huybrechts, I., and Moreno, L.A.

Subjects
Research, Demographic aspects, Health aspects, Sociological research, Child health -- Research, Medical research, Socioeconomics -- Research, Diet -- Health aspects -- Demographic aspects, Social economics -- Research, Medicine, Experimental, Children -- Health aspects
Abstract

INTRODUCTION Social inequalities in health are present from childhood until adult life; socioeconomic status (SES) differences in the risk of morbidity and mortality have been well documented. (1) The burden [...], BACKGROUND/OBJECTIVES: Children from lower socioeconomic status (SES) may be at higher risk of unhealthy eating. We described country-specific dietary patterns among children aged 2-9 years from eight European countries participating in the IDEFICS study and assessed the association of dietary patterns with an additive SES indicator. SUBJECTS/METHODS: Children aged 2-9 years from eight European countries were recruited in 2007-2008. Principal component analysis was applied to identify dietary country-specific patterns. Linear regression analyses were applied to assess their association with SES. RESULTS: Two to four dietary patterns were identified in the participating regions. The existence of a &apos;processed&apos; pattern was found in the eight regions. Also, a &apos;healthy&apos; pattern was identified in seven of the eight regions. In addition, region-specific patterns were identified, reflecting the existing gastronomic and cultural differences in Europe. The &apos;processed&apos; pattern was significantly inversely associated with the SES additive indicator in all countries except Sweden, whereas the &apos;healthy&apos; pattern was positively associated with SES in the Belgian, Estonian, German and Hungarian regions, but was not significant in the Italian, Spanish and Swedish regions. CONCLUSIONS: A &apos;processed&apos; pattern and a &apos;healthy&apos; pattern were found in most of the participating countries in the IDEFICS study, with comparable food item profiles. The results showed a strong inverse association of SES with the &apos;processed&apos; pattern, suggesting that children of parents with lower SES may be at higher risk of unhealthy eating. Therefore, special focus should be given to parents and their children from lower SES levels when developing healthy eating promotion strategies. European Journal of Clinical Nutrition (2014) 68, 811-821;doi:10.1038/ejcn.2014.78; published online 14 May 2014

Published
2014
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34. Milk intake and incident stroke and coronary heart disease in populations of European descent: A Mendelian Randomization study

Author

Vissers, L.E.T., Sluijs, I., Burgess, S., Forouhi, N.G., Freisling, H., Imamura, F., Nilsson, Torbjörn K., Renström, Frida, Weiderpass, E., Aleksandrova, K., Dahm, C.C., Perez-Cornago, A., Schulze, M.B., Tong, T.Y.N., Aune, D., Bonet, C., Boer, J.M.A., Boeing, H., Chirlaque, M.D., Conchi, M.I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M.J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W.M.M., Riboli, E., Wareham, N.J., Danesh, J., Butterworth, A.S., and Van Der Schouw, Y.T.

Subjects
Näringslära, Nutrition and Dietetics, CHD, Milk, Mendelian Randomization, dairy, stroke
Abstract

Higher milk intake has been associated with a lower stroke risk, but not with risk of coronary heart disease (CHD). Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29,328 participants (4,611 stroke; 9,828 CHD) of the EPIC-CVD (8 European countries) and EPIC-NL case-cohort studies. rs4988235, a lactase persistence (LP) single nucleotide polymorphism which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777,024 participants (50,804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483,966 participants (61,612 cases) from CARDIoGRAM, UK Biobank and EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (β=13.7 g/day; 95%CI: 8.4-19.1) and EPIC-NL (36.8 g/day; 20.0-53.5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/day 1.05; 95%CI: 0.94-1.16) or CHD (1.02; 0.96-1.08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (odds ratios 1.02; 0.99-1.05) or CHD (0.99; 0.95-1.03). Current Mendelian Randomization analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk. MEGASTROKE

Published
2021
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38. Dietary patterns and longitudinal change in body mass in European children: a follow-up study on the IDEFICS multicenter cohort

Author

Pala, V., Lissner, L., Hebestreit, A., Lanfer, A., Sieri, S., Siani, A., Huybrechts, I., Kambek, L., Molnar, D., Tornaritis, M., Moreno, L., Ahrens, W., and Krogh, V.

Subjects
Prevention, Methods, Childhood obesity -- Prevention, Child nutrition -- Methods, Obesity in children -- Prevention
Abstract

INTRODUCTION Childhood overweight and obesity increased at an alarming rate in Europe and elsewhere up to about 2000, but now it appears to have levelled off. (1) However, childhood overweight [...], BACKGROUND/OBJECTIVES: Longitudinal studies investigating dietary patterns (DPs) and their association with childhood overweight/obesity are lacking in Europe. We identified DPs and investigated their association with overweight/obesity and changes in body mass index (BMI) in a cohort of European children. SUBJECTS/METHODS: Children aged 2-10 from eight European countries were recruited in 2007-2008. Food frequency questionnaires were collected from 14989 children. BMI and BMI z-scores were derived from height and weight and were used to identify overweight/obese children. After 2 years (mean), anthropometric measurements were repeated in 9427 children. Principal component analysis was used to identify DPs. Simplified DPs (SDPs) were derived from DPs. Adjusted odds ratios (ORs) for overweight/obesity with increasing DP intake were estimated using multilevel logistic regression. Associations of BMI change with DP and SDP were assessed by multilevel mixed regression. Models were adjusted for baseline BMI, age, sex, physical activity and family income. RESULTS: Four DPs were identified that explained 25% of food intake variance: snacking, sweet and fat, vegetables and wholemeal, and protein and water. After 2 years, 849(9%) children became overweight/obese. Children in the highest vegetables and wholemeal tertile had lower risk of becoming overweight/obese (OR: 0.69, 95% confidence intervals (CIs): 0.54-0.88). Children in the highest SDP tertile of vegetables and wholemeal had similarly lower risk of becoming overweight/obese (OR: 0.64, 95% CIs: 0.51-0.82), and their BMI increased by 0.7 kg/[m.sup.2] over the study period-- significantly less than the increase in the lowest tertile (0.84 kg/[m.sup.2]). CONCLUSIONS: Our findings suggest that promoting a diet rich in vegetables and wholemeal cereals may counteract overweight/obesity in children. European Journal of Clinical Nutrition (2013) 67, 1042-1049; doi: 10.1038/ejcn.2013.145; published online 14 August 2013 Keywords: dietary patterns; simplified dietary patterns; children; body mass index; overweight; cohort study

Published
2013
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39. Clustering of multiple lifestyle behaviours and its association to cardiovascular risk factors in children: the IDEFICS study

Author

Bel-Serrat, S., Mouratidou, T., Santaliestra-Pasias, A.M., Iacoviell, L., Kourides, Y.A., Marild, S., Molnar, D., Reisch, L., Siani, A., Stomfai, S., Vanaelst, B., Veidebaum, T., Pigeot, I., Ahrens, W., Krogh, V., and Moreno, L.A.

Subjects
Physiological aspects, Research, Risk factors, Child health -- Research, Lifestyles -- Research, Cardiovascular diseases -- Physiological aspects -- Risk factors, Life style -- Research, Children -- Health aspects
Abstract

INTRODUCTION Increased risk of CVD is characterized by a cluster of metabolic abnormalities, such as abdominal obesity, atherogenic dyslipemia, hypertension, insulin resistance and glucose intolerance. (1) CVD remains the leading [...], BACKGROUND/OBJECTIVES: Individual lifestyle behaviours have independently been associated with cardiovascular diseases (CVD) risk factors in children. This study aimed to identify clustered lifestyle behaviours (dietary, physical activity (PA) and sedentary indicators) and to examine their association with CVD risk factors in children aged 2-9 years. SUBJECTS/METHODS: Participants included 4619 children (51.6% boys) from eight European countries participating in the IDEFICS cross-sectional baseline survey (2007-2008). Insulin resistance, total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, sum of two skinfolds and systolic blood pressure (SBP) z-scores were summed to compute a CVD risk score. Cluster analyses stratified by sex and age groups (2 to < 6 years; 6-9 years) were performed using parental-reported data on fruit, vegetables and sugar-sweetened beverages (SSB) consumption, PA performance and television video/DVD viewing. RESULTS: Five clusters were identified. Associations between CVD risk factors and score, and clusters were obtained by multiple linear regression using cluster 5 ('low beverages consumption and low sedentary') as the reference cluster. SBP was positively associated with clusters 1 ('physically active'; β = 1.34;95% confidence interval (CI): 0.02, 2.67), 2 ('sedentary'; β = 1.84; 95% CI: 0.57, 3.11), 3 ('physically active and sedentary'; β = 1.45;95% CI: 0.15, 2.75) and 4 ('healthy diet'; β = 1.83;95% CI: 0.50, 3.17) in older boys. A positive association was observed between CVD risk score and clusters 2 (b = 0.60;95% CI: 0.20, 1.01), 3 (b = 0.55;95% CI: 0.14, 0.97) and 4 (β = 0.60, 95% CI: 0.18, 1.02) in older boys. CONCLUSIONS: Low television/video/DVD viewing levels and low SSB consumption may result in a healthier CVD profile rather than having a diet rich in fruits and vegetables or being physically active in (pre-)school children. European Journal of Clinical Nutrition (2013) 67, 848-854; doi:10.1038/ejcn.2013.84; published online 1 May 2013 Keywords: cardiovascular diseases; lifestyle; diet; exercise; sedentary lifestyle; child

Published
2013
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40. Milk intake and incident stroke and CHD in populations of European descent: a Mendelian randomisation study

Author

Vissers, L. E. T., primary, Sluijs, I., additional, Burgess, S., additional, Forouhi, N. G., additional, Freisling, H., additional, Imamura, F., additional, Nilsson, T. K., additional, Renström, F., additional, Weiderpass, E., additional, Aleksandrova, K., additional, Dahm, C. C., additional, Perez-Cornago, A., additional, Schulze, M. B., additional, Tong, T. Y. N., additional, Aune, D., additional, Bonet, C., additional, Boer, J. M. A., additional, Boeing, H., additional, Chirlaque, M. D., additional, Conchi, M. I., additional, Imaz, L., additional, Jäger, S., additional, Krogh, V., additional, Kyrø, C., additional, Masala, G., additional, Melander, O., additional, Overvad, K., additional, Panico, S., additional, Sánches, M. J., additional, Sonestedt, E., additional, Tjønneland, A., additional, Tzoulaki, I., additional, Verschuren, W. M. M., additional, Riboli, E., additional, Wareham, N. J., additional, Danesh, J., additional, Butterworth, A. S., additional, and van der Schouw, Y. T., additional

Published
2021
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41. Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Author

Ferrari, P, McKay, J D, Jenab, M, Brennan, P, Canzian, F, Vogel, U, Tjønneland, A, Overvad, K, Tolstrup, J S, Boutron-Ruault, M-C, Clavel-Chapelon, F, Morois, S, Kaaks, R, Boeing, H, Bergmann, M, Trichopoulou, A, Katsoulis, M, Trichopoulos, D, Krogh, V, Panico, S, Sacerdote, C, Palli, D, Tumino, R, Peeters, P H, van Gils, C H, Bueno-de-Mesquita, B, Vrieling, A, Lund, E, Hjartåker, A, Agudo, A, Suarez, L R, Arriola, L, Chirlaque, M-D, Ardanaz, E, Sánchez, M-J, Manjer, J, Lindkvist, B, Hallmans, G, Palmqvist, R, Allen, N, Key, T, Khaw, K-T, Slimani, N, Rinaldi, S, Romieu, I, Boffetta, P, Romaguera, D, Norat, T, and Riboli, E

Published
2012
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46. Alcohol consumption patterns, diet and body weight in 10 European countries

Author

Sieri, S., Krogh, V., Saieva, C., Grobbee, D.E., Bergmann, M., Rohrmann, S., Tjonneland, A., Ferrari, P., Chloptsios, Y., Dilis, V., Jenab, M., Linseisen, J., Wallstrom, P., Johansson, I., Chirlaque, M.D., Sanchez, M.J., Niravong, M., Clavel-Chapelon, F., Welch, A.A., Allen, N.E., Bueno-de-Mesquita, H.B., van der Schouw, Y.T., Sacerdote, C., Panico, S., Parr, C.L., Braaten, T., Olsen, A., Jensen, M.K., Bingham, S., Riboli, E., and Slimani, N.

Subjects
Analysis, Demographic aspects, Health aspects, Human nutrition -- Health aspects -- Analysis, Drinking (Alcoholic beverages) -- Health aspects -- Demographic aspects -- Analysis, Body weight -- Analysis -- Health aspects, Diet -- Health aspects -- Analysis, Drinking of alcoholic beverages -- Health aspects -- Demographic aspects -- Analysis
Abstract

Introduction Europe has the highest level of alcohol consumption in the world (Rehm et al., 2003a). Studies on drinking patterns across Europe, in terms of place of consumption, types of [...], Background/objectives: Europe has the highest level of alcohol consumption in the world. As drinking patterns are important determinants of the beneficial and harmful effects of alcohol consumption, we investigated alcohol consumption in relation to nutrient intake, place of consumption, education and body weight in a sample of adults from 10 European countries. Methods: A 24-h dietary recall interview was conducted on 13 025 men and 23 009 women, aged 35-74 years, from 27 centres participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Means and standard errors of alcohol consumption, adjusted for age, were calculated, stratified by gender and centre. Results: In many centres, higher level drinkers (males consuming >24 g of ethanol/day, equivalent to 42 standard drinks and females consuming >12 g of ethanol/day equivalent to >1 standard drink) obtained more energy from fat and protein and less from sugar than did abstainers. The proportion of energy from starch tended to be higher for male and lower for female higher level drinkers than for abstainers. Female higher level drinkers had a lower body mass index than did abstainers, whereas male higher level drinkers generally weighed more. Male higher level drinkers were less educated than abstainers in Mediterranean countries, but were more educated elsewhere. Female higher level drinkers were usually more educated than were abstainers. Outside the home, consumption (both genders) tended to be at friends' homes, particularly among men in Northern and Central Europe, and in bars in Spain. Conclusions: This study reveals clear geographical differences in drinking habits across Europe, and shows that the characteristics of different alcohol consumption categories also vary. doi: 10.1038/ejcn.2009.76 Keywords: Alcohol; EPIC; 24-h dietary recall; EPIC-Soft; ENDB

Published
2009
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48. A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

Author

Castagné, R., Kelly-Irving, M., Krogh, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Hebels, D.G.A.J., Kleinjans, J.C.S., De Kok, T.M.C.M., Georgiadis, P., Kyrtopoulos, S.A., Vermeulen, R., Stringhini, S., Vineis, P., Chadeau-Hyam, M., Delpierre, C., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, RS: MERLN - Instructive Biomaterials Engineering (IBE), CBITE, RS: MERLN - Cell Biology - Inspired Tissue Engineering (CBITE), Toxicogenomics, RS: GROW - R1 - Prevention, RS: FSE MaCSBio, RS: FPN MaCSBio, RS: FHML MaCSBio, Division Instructive Biomaterials Eng, Cancer Research UK, Commission of the European Communities, IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
0301 basic medicine, Male, Cancer Research, STRESS, Social Determinants of Health, Life course epidemiology, CHILDHOOD, Bioinformatics, Epigenome, 0302 clinical medicine, Gene expression, 030212 general & internal medicine, GENE-EXPRESSION, Genetics & Heredity, DNA methylation, socioeconomic position, Methylation, Middle Aged, Socioeconomic position, CpG site, Italy, life course epidemiology, symbols, Life course approach, Female, HEALTH, medicine.symptom, Life Sciences & Biomedicine, Adult, Inflammation, Biology, 03 medical and health sciences, symbols.namesake, Genetics, medicine, Humans, ddc:613, 0604 Genetics, Science & Technology, CHRONIC LYMPHOCYTIC-LEUKEMIA, Protein, Cancer, 1103 Clinical Sciences, medicine.disease, SOCIAL DETERMINANTS, 030104 developmental biology, Bonferroni correction, Social Class, inflammation, CELLS, gene expression, RISK-FACTORS, BLOOD-SAMPLES, CpG Islands, protein
Abstract

Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

Published
2020

49. Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Zamora-Ros, R., Cayssials, V., Franceschi, S., Kyrø, C., Weiderpass, E., Hennings, J., Sandström, M., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Truong, T., Mancini, F.R., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Karakatsani, A., Martimianaki, G., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Colorado-Yohar, S.M., Ardanaz, E., Almquist, M., Ericson, U., Bueno-de-Mesquita, H.B., Vermeulen, R., Byrnes, G., Scalbert, A., Agudo, A., Rinaldi, S., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
flavonoids, thyroid cancer, cohort, EPIC, intake, polyphenols
Abstract

Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77–1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80–1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55–2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.

Published
2020

50. Reducing socio-economic inequalities in all-cause mortality: A counterfactual mediation approach.

Author

Laine J.E., Baltar V.T., Stringhini S., Gandini M., Chadeau-Hyam M., Kivimaki M., Severi G., Perduca V., Hodge A.M., Dugue P.-A., Giles G.G., Milne R.L., Barros H., Sacerdote C., Krogh V., Panico S., Tumino R., Goldberg M., Zins M., Delpierre C., Laine J.E., Baltar V.T., Stringhini S., Gandini M., Chadeau-Hyam M., Kivimaki M., Severi G., Perduca V., Hodge A.M., Dugue P.-A., Giles G.G., Milne R.L., Barros H., Sacerdote C., Krogh V., Panico S., Tumino R., Goldberg M., Zins M., and Delpierre C.

Abstract

Background: Socio-economic inequalities in mortality are well established, yet the contribution of intermediate risk factors that may underlie these relationships remains unclear. We evaluated the role of multiple modifiable intermediate risk factors underlying socio- economic-associated mortality and quantified the potential impact of reducing early allcause mortality by hypothetically altering socio-economic risk factors. Method(s): Data were from seven cohort studies participating in the LIFEPATH Consortium (total n 179 090). Using both socio-economic position (SEP) (based on occupation) and education, we estimated the natural direct effect on all-cause mortality and the natural indirect effect via the joint mediating role of smoking, alcohol intake, dietary patterns, physical activity, body mass index, hypertension, diabetes and coronary artery disease. Hazard ratios (HRs) were estimated, using counterfactual natural effect models under different hypothetical actions of either lower or higher SEP or education. Result(s): Lower SEP and education were associated with an increase in all-cause mortality within an average follow-up time of 17.5 years. Mortality was reduced via modelled hypothetical actions of increasing SEP or education. Through higher education, the HR was 0.85 [95% confidence interval (CI) 0.84, 0.86] for women and 0.71 (95% CI 0.70, 0.74) for men, compared with lower education. In addition, 34% and 38% of the effect was jointly mediated for women and men, respectively. The benefits from altering SEP were slightly more modest. Conclusion(s): These observational findings support policies to reduce mortality both through improving socio-economic circumstances and increasing education, and by altering intermediaries, such as lifestyle behaviours and morbidities.Copyright © The Author(s) 2019.

Published
2021

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