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430 results on '"Krokan, Hans E."'

1. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Author

Bonagas, Nadilly, Gustafsson, Nina M. S., Henriksson, Martin, Marttila, Petra, Gustafsson, Robert, Wiita, Elisée, Borhade, Sanjay, Green, Alanna C., Vallin, Karl S. A., Sarno, Antonio, Svensson, Richard, Göktürk, Camilla, Pham, Therese, Jemth, Ann-Sofie, Loseva, Olga, Cookson, Victoria, Kiweler, Nicole, Sandberg, Lars, Rasti, Azita, Unterlass, Judith E., Haraldsson, Martin, Andersson, Yasmin, Scaletti, Emma R., Bengtsson, Christoffer, Paulin, Cynthia B. J., Sanjiv, Kumar, Abdurakhmanov, Eldar, Pudelko, Linda, Kunz, Ben, Desroses, Matthieu, Iliev, Petar, Färnegårdh, Katarina, Krämer, Andreas, Garg, Neeraj, Michel, Maurice, Häggblad, Sara, Jarvius, Malin, Kalderén, Christina, Jensen, Amanda Bögedahl, Almlöf, Ingrid, Karsten, Stella, Zhang, Si Min, Häggblad, Maria, Eriksson, Anders, Liu, Jianping, Glinghammar, Björn, Nekhotiaeva, Natalia, Klingegård, Fredrik, Koolmeister, Tobias, Martens, Ulf, Llona-Minguez, Sabin, Moulson, Ruth, Nordström, Helena, Parrow, Vendela, Dahllund, Leif, Sjöberg, Birger, Vargas, Irene L., Vo, Duy Duc, Wannberg, Johan, Knapp, Stefan, Krokan, Hans E., Arvidsson, Per I., Scobie, Martin, Meiser, Johannes, Stenmark, Pål, Berglund, Ulrika Warpman, Homan, Evert J., and Helleday, Thomas

Published
2022
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2. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Author

Visnes, Torkild, Cázares-Körner, Armando, Hao, Wenjing, Wallner, Olov, Masuyer, Geoffrey, Loseva, Olga, Mortusewicz, Oliver, Wiita, Elisée, Sarno, Antonio, Manoilov, Aleksandr, Astorga-Wells, Juan, Jemth, Ann-Sofie, Pan, Lang, Sanjiv, Kumar, Karsten, Stella, Gokturk, Camilla, Grube, Maurice, Homan, Evert J., Hanna, Bishoy M. F., Paulin, Cynthia B. J., Pham, Therese, Rasti, Azita, Berglund, Ulrika Warpman, von Nicolai, Catharina, Benitez-Buelga, Carlos, Koolmeister, Tobias, Ivanic, Dag, Iliev, Petar, Scobie, Martin, Krokan, Hans E., Baranczewski, Pawel, Artursson, Per, Altun, Mikael, Jensen, Annika Jenmalm, Kalderén, Christina, Ba, Xueqing, Zubarev, Roman A., Stenmark, Pål, Boldogh, Istvan, and Helleday, Thomas

Published
2018

3. XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage

Author

Hanssen‐Bauer, Audun, Solvang‐Garten, Karin, Sundheim, Ottar, Peña‐Diaz, Javier, Andersen, Sonja, Slupphaug, Geir, Krokan, Hans E, Wilson, David M, Akbari, Mansour, and Otterlei, Marit

Subjects
Genetics, Animals, Blotting, Western, CHO Cells, Cell Culture Techniques, Cricetinae, Cricetulus, DNA Breaks, Single-Stranded, DNA Polymerase beta, DNA Repair, DNA-Binding Proteins, Dose-Response Relationship, Radiation, HeLa Cells, Humans, Immunoprecipitation, Lasers, Microscopy, Confocal, Models, Biological, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerases, Polynucleotide 5'-Hydroxyl-Kinase, Proliferating Cell Nuclear Antigen, Recombinant Fusion Proteins, Transfection, X-ray Repair Cross Complementing Protein 1, Hela Cells, Environmental Sciences, Biological Sciences, Medical and Health Sciences, Toxicology
Abstract

XRCC1 is a scaffold protein capable of interacting with several DNA repair proteins. Here we provide evidence for the presence of XRCC1 in different complexes of sizes from 200 to 1500 kDa, and we show that immunoprecipitates using XRCC1 as bait are capable of complete repair of AP sites via both short patch (SP) and long patch (LP) base excision repair (BER). We show that POLβ and PNK colocalize with XRCC1 in replication foci and that POLβ and PNK, but not PCNA, colocalize with constitutively present XRCC1-foci as well as damage-induced foci when low doses of a DNA-damaging agent are applied. We demonstrate that the laser dose used for introducing DNA damage determines the repertoire of DNA repair proteins recruited. Furthermore, we demonstrate that recruitment of POLβ and PNK to regions irradiated with low laser dose requires XRCC1 and that inhibition of PARylation by PARP-inhibitors only slightly reduces the recruitment of XRCC1, PNK, or POLβ to sites of DNA damage. Recruitment of PCNA and FEN-1 requires higher doses of irradiation and is enhanced by XRCC1, as well as by accumulation of PARP-1 at the site of DNA damage. These data improve our understanding of recruitment of BER proteins to sites of DNA damage and provide evidence for a role of XRCC1 in the organization of BER into multiprotein complexes of different sizes.

Published
2011

16. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Author

Wang, Yufei, McKay, James D, Rafnar, Thorunn, Wang, Zhaoming, Timofeeva, Maria N, Broderick, Peter, Zong, Xuchen, Laplana, Marina, Wei, Yongyue, Han, Younghun, Lloyd, Amy, Delahaye-Sourdeix, Manon, Chubb, Daniel, Gaborieau, Valerie, Wheeler, William, Chatterjee, Nilanjan, Thorleifsson, Gudmar, Sulem, Patrick, Liu, Geoffrey, Kaaks, Rudolf, Henrion, Marc, Kinnersley, Ben, Vallée, Maxime, Le Calvez-Kelm, Florence, Stevens, Victoria L, Gapstur, Susan M, Chen, Wei V, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Krokan, Hans E, Gabrielsen, Maiken Elvestad, Skorpen, Frank, Vatten, Lars, Njølstad, Inger, Chen, Chu, Goodman, Gary, Benhamou, Simone, Vooder, Tonu, Välk, Kristjan, Nelis, Mari, Metspalu, Andres, Lener, Marcin, Lubiński, Jan, Johansson, Mattias, Vineis, Paolo, Agudo, Antonio, Clavel-Chapelon, Francoise, Bueno-de-Mesquita, H Bas, Trichopoulos, Dimitrios, Khaw, Kay-Tee, Johansson, Mikael, Weiderpass, Elisabete, Tjønneland, Anne, Riboli, Elio, Lathrop, Mark, Scelo, Ghislaine, Albanes, Demetrius, Caporaso, Neil E, Ye, Yuanqing, Gu, Jian, Wu, Xifeng, Spitz, Margaret R, Dienemann, Hendrik, Rosenberger, Albert, Su, Li, Matakidou, Athena, Eisen, Timothy, Stefansson, Kari, Risch, Angela, Chanock, Stephen J, Christiani, David C, Hung, Rayjean J, Brennan, Paul, Landi, Maria Teresa, Houlston, Richard S, and Amos, Christopher I

Published
2014
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17. Damage Specific Mammalian Endonucleases

Author

Haukanes, Bjørn-Ivar, Doetsch, Paul W., Olsen, Lisbeth C., Huq, Ikramul, Krokan, Hans E., Helland, Dag E., Chu, Ernest H. Y., editor, Sutherland, Betsy M., editor, and Woodhead, Avril D., editor

Published
1990
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18. DNA Repair in Mammalian Tissues and Cells

Author

Krokan, Hans E., Olsen, Lisbeth C., Aasland, Rein, Volden, Gunnar, Eggset, Guri, Myrnes, Bjørnar, Johansen, Berit, Haugen, Åge, Helland, Dag E., Chu, Ernest H. Y., editor, Sutherland, Betsy M., editor, and Woodhead, Avril D., editor

Published
1990
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19. Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia

Author

Brenner, Darren R., Amos, Christopher I., Brhane, Yonathan, Timofeeva, Maria N., Caporaso, Neil, Wang, Yufei, Christiani, David C., Bickeböller, Heike, Yang, Ping, Albanes, Demetrius, Stevens, Victoria L., Gapstur, Susan, McKay, James, Boffetta, Paolo, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Krokan, Hans E., Skorpen, Frank, Gabrielsen, Maiken E., Vatten, Lars, Njølstad, Inger, Chen, Chu, Goodman, Gary, Lathrop, Mark, Vooder, Tõnu, Välk, Kristjan, Nelis, Mari, Metspalu, Andres, Broderick, Peter, Eisen, Timothy, Wu, Xifeng, Zhang, Di, Chen, Wei, Spitz, Margaret R., Wei, Yongyue, Su, Li, Xie, Dong, She, Jun, Matsuo, Keitaro, Matsuda, Fumihiko, Ito, Hidemi, Risch, Angela, Heinrich, Joachim, Rosenberger, Albert, Muley, Thomas, Dienemann, Hendrik, Field, John K., Raji, Olaide, Chen, Ying, Gosney, John, Liloglou, Triantafillos, Davies, Michael P.A., Marcus, Michael, McLaughlin, John, Orlow, Irene, Han, Younghun, Li, Yafang, Zong, Xuchen, Johansson, Mattias, Liu, Geoffrey, Tworoger, Shelley S., Le Marchand, Loic, Henderson, Brian E., Wilkens, Lynne R., Dai, Juncheng, Shen, Hongbing, Houlston, Richard S., Landi, Maria T., Brennan, Paul, and Hung, Rayjean J.

Published
2015
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23. Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Author

Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz Raul, Torres-Ruiz Raul, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas, Rodriguez Perales, Sandra, Instituto de Salud Carlos III - ISCIII, European Union (EU), Instituto de Salud Carlos III, and Unión Europea

Subjects
DNA Replication, Guanine, DNA Repair, Poly (ADP-Ribose) Polymerase-1, Mice, Nude, Antineoplastic Agents, DNA Glycosylases, Mice, Cell Line, Tumor, Animals, Humans, Molecular Targeted Therapy, Enzyme Inhibitors, RNA, Small Interfering, Cell Proliferation, DNA, Neoplasm, HCT116 Cells, Survival Analysis, Xenograft Model Antitumor Assays, Tumor Burden, Gene Expression Regulation, Neoplastic, Oxidative Stress, Colonic Neoplasms, Reactive Oxygen Species, DNA Damage, Signal Transduction
Abstract

Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG. Here we hypothesize that OGG1 may represent an attractive target to exploit reactive oxygen species (ROS) elevation in cancer. Although OGG1 depletion is well tolerated in non-transformed cells, we report here that OGG1 depletion obstructs A3 T-cell lymphoblastic acute leukemia growth in vitro and in vivo, validating OGG1 as a potential anti-cancer target. In line with this hypothesis, we show that OGG1 inhibitors (OGG1i) target a wide range of cancer cells, with a favourable therapeutic index compared to non-transformed cells. Mechanistically, OGG1i and shRNA depletion cause S-phase DNA damage, replication stress and proliferation arrest or cell death, representing a novel mechanistic approach to target cancer. This study adds OGG1 to the list of BER factors, e.g. PARP1, as potential targets for cancer treatment. S.R.P.'s laboratory is partially funded by funds from the Spanish National Research and Development Plan, Instituto de Salud Carlos III and FEDER [PI17/02303 to S.R.P]; R.T.R. is supported by a fellowship from the AECC scientific foundation; J.M.B. is supported by Spanish Ministry of Education, Culture and Sport [FPU15/01978]; J.B.'s laboratory is partially funded by FEDER funds, H2020 BRIDGES project and the Spanish Network on Rare Diseases (CIBERER) [FIS PI16/00440]; Faculty of Medicine at the Norwegian University of Science and Technology and the Central Norway Regional Health Authority supports [46056921 to A.S. and H.E.K.]; Svanhild and Arne Must's Fund for Medical Research (to A.S. and H.E.K.); Norwegian Research Council (to T.V.); SIN-TEF SEP project 102020885 (to T.V.); Vinnova (to A.C.K and P.S.); the Torsten and Ragnar Soderberg Foundation (to T.H.) and the Helleday Foundation (to C.B.). Funding for open access charge and project support: European Union's Horizon 2020 research and innovation programunder the Marie Sklodowska-Curie grant agreement [722729 to A.P., B.M.F.H., T.H.]; European Research Council [ERC TAROX-695376 to T.H.]; Swedish Research Council (to T.H. and P.S.); Swedish Cancer Society (to T.H. and P.S.); Swedish Children's Cancer Foundation (to T.H.); Swedish Pain Relief Foundation (to T.H.). Sí

Published
2020

30. Genetic analysis of the murine u opioid receptor: increased complexity of Oprm gene splicing

Author

Kvam, Tor-Morten, Baar, Cecilie, Rakvag, Trude T., Kaasa, Stein, Krokan, Hans E., and Skorpen, Frank

Subjects
Genetic engineering -- Research, Messenger RNA -- Research, Opioids -- Research, Polymerase chain reaction -- Usage, Science and technology
Abstract

Byline: Tor-Morten Kvam (1), Cecilie Baar (1), Trude T. Rakvag (1), Stein Kaasa (1,2), Hans E. Krokan (1), Frank Skorpen (1) Keywords: Mu opioid receptor; Alternative splicing; Splice variants Abstract: Evidence exists that u analgesics such as morphine, methadone and fentanyl may act through distinct u opioid receptor mechanisms. It has been proposed that the functional diversity of u opioid receptors may be related to alternative splicing of the Oprm gene. Although a number of u opioid receptor mRNA splice variants have been reported, their biological relevance has been controversial, due in part to their very low abundance and a general lack of validation from independent laboratories. We have identified 11 of 17 proposed exons as well as the majority of exon combinations used to make 21 differentially spliced Oprm mRNAs from mouse whole brain cDNA, using polymerase chain reaction (PCR) conditions different from those used by the single other group that has reported multiple splice forms. Alternative splicing was shown to occur at both the 5 and 3 termini. Moreover, verification of a short variant, containing exons 1 and 4 only, suggests that splicing also occurs directly between 5 and 3 exons. Notably, a novel splice variant, MOR-1T, demonstrates for the first time that exon 4 can be used in combination with further downstream exons to make the 3 -end of MOR-1 splice variants. The putative protein encoded by MOR-1T is predicted to be identical to that of MOR-1, implying that the MOR-1 protein can be generated from at least five differentially spliced mRNAs. Our results support the view that the Oprm gene undergoes extensive alternative splicing, as a likely major contributor to the diversity of u opioid receptors. Author Affiliation: (1) Institute of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway (2) Unit for Applied Clinical Research, Department of Environmental Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway Article History: Registration Date: 19/11/2003 Received Date: 12/10/2003 Accepted Date: 03/11/2003 Online Date: 09/01/2004

Published
2004

34. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

Author

Aas, Per Arne, Otterlei, Marit, Falnes, Pal O., Vagbo, Cathrine B., Skorpen, Frank, Akbari, Mansour, Sundheim, Ottar, Bjoras, Magnar, Slupphaug, Geir, Seeberg, Erling, and Krokan, Hans E.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Per Arne Aas [1, 2]; Marit Otterlei [1, 2]; PÃ¥l Ã. Falnes [2, 3]; Cathrine B. VÃ¥gbø [1]; Frank Skorpen [1]; Mansour Akbari [1]; Ottar Sundheim [1]; Magnar BjørÃ¥s [...]

Published
2003
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35. Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

Author

Timofeeva, Maria N., Hung, Rayjean J., Rafnar, Thorunn, Christiani, David C., Field, John K., Bickeböller, Heike, Risch, Angela, McKay, James D., Wang, Yufei, Dai, Juncheng, Gaborieau, Valerie, McLaughlin, John, Brenner, Darren, Narod, Steven A., Caporaso, Neil E., Albanes, Demetrius, Thun, Michael, Eisen, Timothy, Wichmann, H.-Erich, Rosenberger, Albert, Han, Younghun, Chen, Wei, Zhu, Dakai, Spitz, Margaret, Wu, Xifeng, Pande, Mala, Zhao, Yang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Krokan, Hans E., Gabrielsen, Maiken Elvestad, Skorpen, Frank, Vatten, Lars, Njølstad, Inger, Chen, Chu, Goodman, Gary, Lathrop, Mark, Benhamou, Simone, Vooder, Tõnu, Välk, Kristjan, Nelis, Mari, Metspalu, Andres, Raji, Olaide, Chen, Ying, Gosney, John, Liloglou, Triantafillos, Muley, Thomas, Dienemann, Hendrik, Thorleifsson, Gudmar, Shen, Hongbing, Stefansson, Kari, Brennan, Paul, Amos, Christopher I., Houlston, Richard, and Landi, Maria Teresa

Published
2012
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41. Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Author

Visnes, Torkild, primary, Benítez-Buelga, Carlos, additional, Cázares-Körner, Armando, additional, Sanjiv, Kumar, additional, Hanna, Bishoy M F, additional, Mortusewicz, Oliver, additional, Rajagopal, Varshni, additional, Albers, Julian J, additional, Hagey, Daniel W, additional, Bekkhus, Tove, additional, Eshtad, Saeed, additional, Baquero, Juan Miguel, additional, Masuyer, Geoffrey, additional, Wallner, Olov, additional, Müller, Sarah, additional, Pham, Therese, additional, Göktürk, Camilla, additional, Rasti, Azita, additional, Suman, Sharda, additional, Torres-Ruiz, Raúl, additional, Sarno, Antonio, additional, Wiita, Elisée, additional, Homan, Evert J, additional, Karsten, Stella, additional, Marimuthu, Karthick, additional, Michel, Maurice, additional, Koolmeister, Tobias, additional, Scobie, Martin, additional, Loseva, Olga, additional, Almlöf, Ingrid, additional, Unterlass, Judith Edda, additional, Pettke, Aleksandra, additional, Boström, Johan, additional, Pandey, Monica, additional, Gad, Helge, additional, Herr, Patrick, additional, Jemth, Ann-Sofie, additional, El Andaloussi, Samir, additional, Kalderén, Christina, additional, Rodriguez-Perales, Sandra, additional, Benítez, Javier, additional, Krokan, Hans E, additional, Altun, Mikael, additional, Stenmark, Pål, additional, Berglund, Ulrika Warpman, additional, and Helleday, Thomas, additional

Published
2020
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47. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Author

Hung, Rayjean J., McKay, James D., Gaborieau, Valerie, Boffetta, Paolo, Hashibe, Mia, Zaridze, David, Mukeria, Anush, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Chen, Chu, Goodman, Gary, Field, John K., Liloglou, Triantafillos, Xinarianos, George, Cassidy, Adrian, McLaughlin, John, Liu, Geoffrey, Narod, Steven, Krokan, Hans E., Skorpen, Frank, Elvestad, Maiken Bratt, Hveem, Kristian, Vatten, Lars, Linseisen, Jakob, Clavel-Chapelon, Françoise, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, Lund, Eiliv, Martinez, Carmen, Bingham, Sheila, Rasmuson, Torgny, Hainaut, Pierre, Riboli, Elio, Ahrens, Wolfgang, Benhamou, Simone, Lagiou, Pagona, Trichopoulos, Dimitrios, Holcátová, Ivana, Merletti, Franco, Kjaerheim, Kristina, Agudo, Antonio, Macfarlane, Gary, Talamini, Renato, Simonato, Lorenzo, Lowry, Ray, Conway, David I., Znaor, Ariana, Healy, Claire, Zelenika, Diana, Boland, Anne, Delepine, Marc, Foglio, Mario, Lechner, Doris, Matsuda, Fumihiko, Blanche, Helene, Gut, Ivo, Heath, Simon, Lathrop, Mark, and Brennan, Paul

Published
2008
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