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4. Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

Author

Wang, Jialiang S., Kamath, Tushar, Mazur, Courtney M., Mirzamohammadi, Fatemeh, Rotter, Daniel, Hojo, Hironori, Castro, Christian D., Tokavanich, Nicha, Patel, Rushi, Govea, Nicolas, Enishi, Tetsuya, Wu, Yunshu, da Silva Martins, Janaina, Bruce, Michael, Brooks, Daniel J., Bouxsein, Mary L., Tokarz, Danielle, Lin, Charles P., Abdul, Abdul, Macosko, Evan Z., Fiscaletti, Melissa, Munns, Craig F., Ryder, Pearl, Kost-Alimova, Maria, Byrne, Patrick, Cimini, Beth, Fujiwara, Makoto, Kronenberg, Henry M., and Wein, Marc N.

Published
2021
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8. List of Contributors

Author

Abraham, David, primary, Almeida, Maria, additional, Ambrogini, Elena, additional, Arnold, Andrew, additional, Bakos, Bence, additional, Bergwitz, Clemens, additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Binkley, Neil, additional, Bisello, Alessandro, additional, Bonewald, L.F., additional, Bou-Gharios, George, additional, Bouillon, Roger, additional, Bouxsein, Mary L., additional, Boyce, Brendan F., additional, Boyd, Steven, additional, Brandi, Maria Luisa, additional, Burr, David B., additional, Calvi, Laura M., additional, Canalis, Ernesto, additional, Cao, Xu, additional, Carmeliet, Geert, additional, Carpenter, Thomas O., additional, Chang, Wenhan, additional, Chim, Shek Man, additional, Choudhary, Shilpa, additional, Christakos, Sylvia, additional, Chun, Yong-Hee Patricia, additional, Cipriani, Cristiana, additional, Civitelli, Roberto, additional, Clemens, Thomas L., additional, Collins, Michael T., additional, Conte, Caterina, additional, Cooper, Mark S., additional, Cornish, Jillian, additional, Cremers, Serge, additional, Dawson-Hughes, Bess, additional, de Crombrugghe, Benoit, additional, DeLuca, Hector F., additional, Dempster, David W., additional, Drake, Matthew T., additional, Ducy, Patricia, additional, Ebetino, Frank H., additional, Engelke, Klaus, additional, Erben, Reinhold G., additional, Eyre, David R., additional, Farber, Charles R., additional, Feigenson, Marina, additional, Ferron, Mathieu, additional, Florenzano, Pablo, additional, Fontana, Francesca, additional, Foster, Brian L., additional, Friedman, Peter A., additional, Fukumoto, Seiji, additional, Gamer, Laura W., additional, Gardella, Thomas J., additional, Garnero, Patrick, additional, Genant, Harry K., additional, Giusti, Francesca, additional, Göbel, Andy, additional, Goltzman, David, additional, Gorski, Jeffrey P., additional, Griffith, James, additional, G Russell, R. Graham, additional, Hankenson, Kurt D., additional, Hannan, Fadil M., additional, Harris, Stephen E., additional, Hartley, Iris R., additional, Hartmann, Christine, additional, Heaney, Robert P., additional, Hendy, Geoffrey N., additional, Hilton, Matthew J., additional, Hofbauer, Lorenz C., additional, Holdsworth, Gill, additional, Hsu, Yi-Hsiang, additional, Hudson, David M., additional, Hurley, Marja, additional, Insogna, Karl L., additional, Jilka, Robert L., additional, Johnson, Mark L., additional, Johnson, Rachelle W., additional, Jones, Glenville, additional, Judex, Stefan, additional, Jüppner, Harald, additional, Kalajzic, Ivo, additional, Karsenty, Gérard, additional, Ke, Hua Zhu, additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Klein-Nulend, J., additional, Ko, Frank C., additional, Kobayashi, Yasuhiro, additional, Konrad, Martin, additional, Kostenuik, Paul J., additional, Kovacs, Christopher S., additional, Kremer, Richard, additional, Krishnan, Venkatesh, additional, Kronenberg, Henry M., additional, Lakatos, Peter A., additional, Liberman, Uri A., additional, Lorenzo, Joseph A., additional, Lynch, Conor C., additional, Lyons, Karen M., additional, Ma, Y. Linda, additional, Maes, Christa, additional, Mannstadt, Michael, additional, Manolagas, Stavros, additional, Marcus, Robert, additional, Maridas, David E., additional, Marie, Pierre J., additional, Marini, Francesca, additional, Markovac, Jasna, additional, Martin, T. John, additional, Matthews, Brya G., additional, Maurizi, Antonio, additional, Mirfakhraee, Sasan, additional, Moe, Sharon M., additional, Monroe, David G., additional, Moreira, Carolina A., additional, Müller, Ralph, additional, Musson, David S., additional, Nakatani, Teruyo, additional, Naot, Dorit, additional, Napoli, Nicola, additional, Naveh-Many, Tally, additional, Nemeth, Edward F., additional, Nickolas, Thomas L., additional, Ominsky, Michael S., additional, Ono, Noriaki, additional, Ornitz, David M., additional, Partridge, Nicola C., additional, Patel, Vihitaben S., additional, Pike, J. Wesley, additional, Pilbeam, Carol, additional, Plum, Lori, additional, Potts, John T., additional, Puzas, J. Edward, additional, Rachner, Tilman D., additional, Rakian, Audrey, additional, Rakian, Rubie, additional, Renthal, Nora E., additional, Rhoades (Sterling), Julie A., additional, Riminucci, Mara, additional, Roberts, Scott J., additional, Robey, Pamela Gehron, additional, Rogers, Michael J., additional, Roodman, G. David, additional, Rosen, Clifford J., additional, Rosen, Vicki, additional, Rowe, David W., additional, Rubin, Janet, additional, Rubin, Clinton T., additional, Schlingmann, Karl P., additional, Seeman, Ego, additional, Seibel, Markus J., additional, Sempos, Chris, additional, Shoback, Dolores M., additional, Silve, Caroline, additional, Silver, Justin, additional, Sims, Natalie A., additional, Singer, Frederick R., additional, Stains, Joseph P., additional, Stegen, Steve, additional, Stern, Paula H., additional, Tabacco, Gaia, additional, Takacs, Istvan, additional, Takahashi, Naoyuki, additional, Tay, Donovan, additional, Teti, Anna, additional, Thakker, Rajesh V., additional, Tomlinson, Ryan E., additional, Tonelli, Francesco, additional, Towler, Dwight A., additional, Tsourdi, Elena, additional, Tu, Chia-Ling, additional, Udagawa, Nobuyuki, additional, Weaver, Connie M., additional, Wein, Marc N., additional, Weinstein, Lee S., additional, Weis, MaryAnn, additional, Whyte, Michael P., additional, Williams, Bart O., additional, Xu, Xin, additional, Yakar, Shoshana, additional, Yang, Yingzi, additional, Zanotti, Stefano, additional, and Zhou, Hong, additional

Published
2020
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11. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling

Author

Nishimori, Shigeki, OMeara, Maureen J., Castro, Christian D., Noda, Hiroshi, Cetinbas, Murat, Martins, Janaina da Silva, Ayturk, Ugur, Brooks, Daniel J., Bruce, Michael, Nagata, Mizuki, Ono, Wanida, Janton, Christopher J., Bouxsein, Mary L., Foretz, Marc, Berdeaux, Rebecca, Sadreyev, Ruslan I., Gardella, Thomas J., Juppner, Harald, Kronenberg, Henry M., and Wein, Marc N.

Subjects
Bone density -- Analysis, Parathyroid hormones -- Analysis, Cyclic adenosine monophosphate, Hormones, Animal genetic engineering, Phenotypes, Health care industry
Abstract

The parathyroid hormone 1 receptor (PTH1R) mediates the biologic actions of parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP). Here, we showed that salt-inducible kinases (SIKs) are key kinases that control the skeletal actions downstream of PTH1R and that this GPCR, when activated, inhibited cellular SIK activity. Sik gene deletion led to phenotypic changes that were remarkably similar to models of increased PTH1R signaling. In growth plate chondrocytes, PTHrP inhibited SIK3, and ablation of this kinase in proliferating chondrocytes rescued perinatal lethality of PTHrP-null mice. Combined deletion of Sik2 and Sik3 in osteoblasts and osteocytes led to a dramatic increase in bone mass that closely resembled the skeletal and molecular phenotypes observed when these bone cells express a constitutively active PTH1R that causes Jansen's metaphyseal chondrodysplasia. Finally, genetic evidence demonstrated that class IIa histone deacetylases were key PTH1R-regulated SIK substrates in both chondrocytes and osteocytes. Taken together, our findings establish that SIK inhibition is central to PTH1R action in bone development and remodeling. Furthermore, this work highlights the key role of cAMP-regulated SIKs downstream of GPCR action., Introduction The parathyroid hormone 1 receptor (PTH1R) is a class B, 7-transmembrane G protein-coupled receptor (GPCR) (1) whose biologic actions control mineral ion homeostasis (2), bone development (3, 4), and [...]

Published
2019
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15. Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo

Author

Massengale, Mei, primary, Massengale, Justin L., additional, Benson, Catherine R., additional, Barywano, Ninib, additional, Oki, Toshihiko, additional, Steinhauser, Matthew L., additional, Wang, Alissa, additional, Balani, Deepak, additional, Oh, Luke S., additional, Randolph, Mark A., additional, Gill, Thomas J., additional, Kronenberg, Henry M., additional, and Scadden, David T., additional

Published
2023
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16. A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Author

Sato, Tadatoshi, Verma, Shiv, Andrade, Christian D. Castro, Omeara, Maureen, Campbell, Nia, Wang, Jialiang S., Cetinbas, Murat, Lang, Audrey, Ausk, Brandon J., Brooks, Daniel J., Sadreyev, Ruslan I., Kronenberg, Henry M., Lagares, David, Uda, Yuhei, Pajevic, Paola Divieti, Bouxsein, Mary L., Gross, Ted S., and Wein, Marc N.

Published
2020
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28. List of Contributors

Author

Bowles, Annie C., primary, Caetano-Silva, Soraia P., additional, Colombier, Pauline, additional, Correa, Diego, additional, Craft, April M., additional, Decker, Rebekah S., additional, Farrell, Eric, additional, Galloway, Jenna L., additional, Grinstein, Mor, additional, Javaheri, Behzad, additional, Kiernan, Caoimhe, additional, Knuth, Callie, additional, Koyama, Eiki, additional, Kronenberg, Henry M., additional, Narcisi, Roberto, additional, Novicky, Astrid, additional, Ono, Noriaki, additional, Pacifici, Maurizio, additional, Pitsillides, Andrew A., additional, Risbud, Makarand V., additional, Sandell, Linda J., additional, Seale, Nailah M., additional, Varghese, Shyni, additional, and Zeng, Yuze, additional

Published
2018
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31. Parathyroid hormone regulates fates of murine osteoblast precursors in vivo

Author

Balani, Deepak H., Ono, Noriaki, and Kronenberg, Henry M.

Subjects
Parathyroid hormones -- Health aspects, Osteoblasts -- Health aspects, Health care industry
Abstract

Teriparatide, a recombinant form of parathyroid hormone (PTH), is the only approved treatment for osteoporosis that increases the rate of bone formation. Teriparatide increases osteoblast numbers by suppressing osteoblast apoptosis and activating bone-lining cells. No direct evidence for teriparatide's actions on early cells of the osteoblast lineage has been demonstrated. Here, we have employed a lineage-tracing strategy that uses a tamoxifen-dependent, promoter-driven cre to mark early cells of the osteoblast lineage in adult mice. We show that teriparatide increases the numbers of osteoblast precursors and drives their differentiation into mature osteoblasts. Unexpectedly, following withdrawal of teriparatide therapy, bone marrow adipocytes increased dramatically in number. Some of these adipocytes derived from cells marked by Sox9-cre expression weeks earlier. Continued therapy with teriparatide prevented the appearance of adipocytes. Selective, inducible deletion of the PTH receptor in Sox9-cre cells demonstrated that PTH receptor expression is required for teriparatide-mediated increases in early osteoblast precursors. The increase in early precursors after teriparatide administration was associated with robust suppression of precursor apoptosis without affecting their rate of proliferation. Thus, teriparatide increases the numbers of early cells of the osteoblast lineage, hastens their differentiation into osteoblasts, and suppresses their differentiation into adipocytes in vivo., Introduction Parathyroid hormone (PTH) acts as a major regulator of mammalian calcium homeostasis, partly through actions on bone (1). When PTH 1-34 is administered by once-daily subcutaneous injection to humans [...]

Published
2017
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39. Anabolic action of parathyroid hormone regulated by the β₂-adrenergic receptor

Author

Hanyu, Ryo, Wehbi, Vanessa L., Hayata, Tadayoshi, Moriya, Shuichi, Feinstein, Timothy N., Ezura, Yoichi, Nagao, Masashi, Saita, Yoshitomo, Hemmi, Hiroaki, Notomi, Takuya, Nakamoto, Tetsuya, Schipani, Ernestina, Takeda, Shu, Kaneko, Kazuo, Kurosawa, Hisashi, Karsenty, Gerard, Kronenberg, Henry M., Vilardaga, Jean-Pierre, and Noda, Masaki

Published
2012

43. Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice

Author

Daley, Eileen J, primary, Yoon, Sung-Hee, additional, Reyes, Monica, additional, Bruce, Michael, additional, Brooks, Daniel J, additional, Bouxsein, Mary, additional, Potts, John T, additional, Kronenberg, Henry M, additional, Wein, Marc N, additional, Lanske, Beate, additional, Jüppner, Harald, additional, and Gardella, Thomas J, additional

Published
2022
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45. Contributors

Author

Achermann, John C., primary, Aiello, Lloyd P., additional, Alexander, Erik K., additional, Allen, Rebecca H., additional, Altshuler, David, additional, Anderson, Mark S., additional, Atkinson, Mark A., additional, Bahn, Rebecca S., additional, Barker, Jennifer M., additional, Basson, Rosemary, additional, Berga, Sarah L., additional, Bhasin, Shalender, additional, Birnbaum, Morris J., additional, Black, Dennis M., additional, Bose, Anirban, additional, Boulton, Andrew J.M., additional, Braunstein, Glenn D., additional, Bremner, William J., additional, Brent, Gregory A., additional, Bringhurst, F. Richard, additional, Brownlee, Michael, additional, Bulun, Serdar E., additional, Burant, Charles F., additional, Bushinsky, David A., additional, Cone, Roger D., additional, Cooke, David W., additional, Cooper, Mark E., additional, Cryer, Philip E., additional, Dattani, Mehul T., additional, Davies, Terry F., additional, de Paula, Francisco J.A., additional, Demay, Marie B., additional, DiVall, Sara A., additional, Elmquist, Joel K., additional, Filetti, Sebastiano, additional, Gevers, Evelien F., additional, Ghigo, Ezio, additional, Goldberg, Anne C., additional, Goldberg, Ira J., additional, Gottlieb, Peter A., additional, Grinspoon, Steven K., additional, Grumbach, Melvin M., additional, Hay, Ian D., additional, Hayes, Frances J., additional, Hickey, Martha, additional, Hirschhorn, Joel N., additional, Ho, Ken K.Y., additional, Hughes, Ieuan A., additional, Kaiser, Ursula, additional, Kaunitz, Andrew M., additional, Klein, Samuel, additional, Kleinberg, David, additional, Kronenberg, Henry M., additional, Lamberts, Steven W.J., additional, Lanfranco, Fabio, additional, Larsen, P. Reed, additional, Laurberg, Peter, additional, Lazar, Mitchell A., additional, Loriaux, Lynn, additional, Low, Malcolm J., additional, Majithia, Amit R., additional, Marx, Stephen J., additional, Matsumoto, Alvin M., additional, Melmed, Shlomo, additional, Monk, Rebeca D., additional, Murray, Robert D., additional, Newell-Price, John D.C., additional, Nitsche, Joshua F., additional, Öberg, Kjell, additional, Plutzky, Jorge, additional, Polonsky, Kenneth S., additional, Radovick, Sally, additional, Robinson, Alan G., additional, Romijn, Johannes A., additional, Rosen, Clifford J., additional, Salvatore, Domenico, additional, Schlumberger, Martin-Jean, additional, Semenkovich, Clay F., additional, Sluss, Patrick M., additional, Stewart, Paul M., additional, Strasburger, Christian J., additional, Styne, Dennis M., additional, van den Beld, Annewieke W., additional, Vella, Adrian, additional, Verbalis, Joseph G., additional, Vinik, Aaron I., additional, Weetman, Anthony P., additional, Wells, Samuel A., additional, and Young, William F., additional

Published
2016
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49. List of Contributors

Author

Aliprantis, Antonios O., primary, Bello-Irizarry, Sheila N., additional, Berry, Ryan, additional, Briot, Karine, additional, Charles, Julia F., additional, Choi, Yongwon, additional, Daiss, John L., additional, Dayer, Jean-Michel, additional, de Mesy Bentley, Karen L., additional, Einhorn, Thomas A., additional, Faccio, Roberta, additional, Fretz, Jackie A., additional, Garlet, Gustavo P., additional, Gerstenfeld, Louis C., additional, Geusens, Piet, additional, Goldring, Mary B., additional, Goldring, Steven R., additional, Gravallese, Ellen M., additional, Graves, Dana T., additional, Grčević, Danka, additional, Horowitz, Mark C., additional, Ishii, Masaru, additional, Kayal, Rayyan A., additional, Kikuta, Junichi, additional, Klibansky, Anne, additional, Kovačić, Natasa, additional, Kronenberg, Henry M., additional, Lee, Sun-Kyeong, additional, Lorenzo, Joseph, additional, MacDougald, Ormond, additional, Martin, T. John, additional, Nakamura, Mary C., additional, Nanes, Mark S., additional, Nevius, Erin, additional, Nishitani, Kohei, additional, O’Brien, Charles A., additional, Oates, Thomas, additional, Penninger, Josef Martin, additional, Pereira, João P., additional, Quinn, Julian M.W., additional, Rodeheffer, Matthew S., additional, Roodman, Garson David, additional, Rosen, Clifford J., additional, Roux, Christian, additional, Schett, Georg, additional, Schwarz, Edward M., additional, Sigl, Verena, additional, Silbermann, Rebecca, additional, Sims, Natalie A., additional, Steen, Brandon M., additional, Sylvester, Francisco A., additional, Takayanagi, Hiroshi, additional, Teitelbaum, Steven L., additional, Vella, Anthony T., additional, and Wu, Joy Y., additional

Published
2016
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50. Note from the Editors

Author

Kronenberg, Henry M., primary, Larsen, P. Reed, additional, Melmed, Shlomo, additional, and Polonsky, Kenneth S., additional

Published
2016
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