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12. Chlamydial clinical isolates show subtle differences in persistence phenotypes and growth in vitro.

Author

Thomas, M, Lawrence, A, Kroon, S, Vodstrcil, LA, Phillips, S, Hocking, JS, Timms, P, Huston, WM, Thomas, M, Lawrence, A, Kroon, S, Vodstrcil, LA, Phillips, S, Hocking, JS, Timms, P, and Huston, WM

Abstract

Urogenital Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection throughout the world. While progress has been made to better understand how type strains develop and respond to environmental stress in vitro, very few studies have examined how clinical isolates behave under similar conditions. Here, we examined the development and persistence phenotypes of several clinical isolates, to determine how similar they are to each other, and the type strain C. trachomatis D/UW-3/Cx. The type strain was shown to produce infectious progeny at a higher magnitude than each of the clinical isolates, in each of the six tested cell lines. All chlamydial strains produced the highest number of infectious progeny at 44 h post-infection in the McCoy B murine fibroblast cell line, yet showed higher levels of infectivity in the MCF-7 human epithelial cell line. The clinical isolates were shown to be more susceptible than the type strain to the effects of penicillin and iron deprivation persistence models in the MCF-7 cell line. While subtle differences between clinical isolates were observed throughout the experiments conducted, no significant differences were identified. This study reinforces the importance of examining clinical isolates when trying to relate in vitro data to clinical outcomes, as well as the importance of considering the adaptations many type strains have to being cultured in vitro.

Published
2021

13. Idiopathic and hereditary haemorrhagic telangiectasia associated pulmonary arteriovenous malformations: comparison of clinical and radiographic characteristics

Author

Externen Hematologie, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Circulatory Health, Kroon, S., van den Heuvel, D. A.F., Vos, J. A., van Leersum, M., van Strijen, M. J.L., Post, M. C., Mager, J. J., Snijder, R. J., Externen Hematologie, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Circulatory Health, Kroon, S., van den Heuvel, D. A.F., Vos, J. A., van Leersum, M., van Strijen, M. J.L., Post, M. C., Mager, J. J., and Snijder, R. J.

Published
2021

19. A randomized, multicentre study of directed daylight exposure times of 1½ vs. 2½ h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp

Author

Wiegell, S. R., Fabricius, S., Stender, I. M., Berne, B., Kroon, S., Andersen, B. L., Mrk, C., Sandberg, C., Jemec, G. B.E., Mogensen, M., Brocks, K. M., Philipsen, P. A., Heydenreich, J., Hædersdal, M., and Wulf, H. C.

Published
2011
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23. De bijdrage van de Werkplaats aan de professionalisering van leerkrachten ten aanzien van diversiteit en praktijkonderzoek

Author

Gaikhorst, L., Kroon, S., Schaveling, J., de Ruig, N., Soeterik, I., Edzes, H., Fleurke, M., Volman, M., Educational Sciences (RICDE, FMG), Developmental Disorders and Special Education (RICDE, FMG), and Publicaties door niet-onderzoekers (RICDE, FMG)

Abstract

Leerkrachten in de Amsterdamsegrootstedelijke context hebben te makenmet een zeer diverse leerlingpopulatie(Fukkink & Oostdam, 2017). Leerkrachtenwillen graag goed inspelen op de groteverschillen tussen leerlingen, maarervaren ook hoe complex dit is (Gaikhorst,Beishuizen, Roosenboom, & Volman, 2016).

Published
2019

26. Learning Dynamics of Linear Denoising Autoencoders

Author

Pretorius, A., Kroon, S., and Herman Kamper

Subjects
FOS: Computer and information sciences, Computer Science::Machine Learning, Computer Science - Machine Learning, Statistics - Machine Learning, Machine Learning (stat.ML), Computer Science::Symbolic Computation, Machine Learning (cs.LG)
Abstract

Denoising autoencoders (DAEs) have proven useful for unsupervised representation learning, but a thorough theoretical understanding is still lacking of how the input noise influences learning. Here we develop theory for how noise influences learning in DAEs. By focusing on linear DAEs, we are able to derive analytic expressions that exactly describe their learning dynamics. We verify our theoretical predictions with simulations as well as experiments on MNIST and CIFAR-10. The theory illustrates how, when tuned correctly, noise allows DAEs to ignore low variance directions in the inputs while learning to reconstruct them. Furthermore, in a comparison of the learning dynamics of DAEs to standard regularised autoencoders, we show that noise has a similar regularisation effect to weight decay, but with faster training dynamics. We also show that our theoretical predictions approximate learning dynamics on real-world data and qualitatively match observed dynamics in nonlinear DAEs., 14 pages, 7 figures, accepted at the 35th International Conference on Machine Learning (ICML) 2018

Published
2018

35. De Limburgse Tonen

Author

Gussenhoven, C., Heijenrath, L., Kroon, S., Heijenrath, L., and Kroon, S.

Subjects
Grammar and Cognition
Abstract

Item does not contain fulltext

Published
2007

36. Dialect in Limburg, de zachte g en zoveel meer

Author

Delnoy, P., Kroon, S., Heijenrath, L., Heijenrath, L., and Kroon, S.

Subjects
2006 [Jaarboek (Veldeke Limburg)], Jaarboek (Veldeke Limburg): 2006, Communicative Competences
Abstract

Item does not contain fulltext

Published
2007

37. De scheiding van Nederlandse en Duitse dialecten: geografische versus perceptieve afstand in het Kleverlands

Author

Giesbers, C.H.E., Hout, R.W.N.M. van, Bezooijen, R.A.M.G. van, Heijenrath, L., Kroon, S., Heijenrath, L., and Kroon, S.

Subjects
Jaarboek (Veldeke Limburg), Dialect op de grens van twee talen. Een onderzoek naar taalvariatie en taalkeuze in het Kleverlandse dialectgebied, Language in Time and Space, A study of language variation and language choice in the Kleve dialect area [Dialect at the boundary of two languages], Communicative Competences
Abstract

Item does not contain fulltext

Published
2007

38. Dialect en schoolsucces

Author

Kroon, S., Vallen, T., Heijenrath, L., Heijenrath, L., and Kroon, S.

Subjects
Communicative Competences
Abstract

Item does not contain fulltext

Published
2007

40. Dialectbeleid niet altijd zinvol

Author

Jaspaert, K. and Kroon, S.

Subjects
Communicative Competences
Abstract

Item does not contain fulltext 3 p.

Published
2007

42. Chinese and globalization

Author

Kroon, S., Blommaert, J.M.E., Dong, K. J., Duarte, J., Gogolin, J., and Language and Globalization

Published
2013

43. Globalization in the margins

Author

Wang, X., Spotti, M., Juffermans, K., Cornips, L., Kroon, S., Blommaert, J.M.E., and Language and Globalization

Published
2013

47. Methoden van onderzoek naar lexicale variatie

Author

Bezooijen, R.A.M.G. van, De Caluwe, J., Geeraerts, D., Kroon, S., Marmadouh, V., Soetaert, R., Top, L., Vallen, T., De Caluwe, J., Geeraerts, D., Kroon, S., Marmadouh, V., Soetaert, R., Top, L., and Vallen, T.

Subjects
Structure and Variation, Structuur en variatie
Abstract

Item does not contain fulltext

Published
2002

49. Contributions to the Development of a European Language Policy

Author

Bot, C.L.J. de, Kroon, S., Nelde, P., Velde, H. Van de, Bot, K. de, Bot, K. de, Kroon, S., Nelde, P., and Velde, H. Van de

Subjects
Variation and standard language (VAST), Variatie en standaardtaal (VAST), Taal en maatschappij
Abstract

Item does not contain fulltext

Published
2001

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