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12 results on '"Krul, Damaris"'

3. Outbreak of vancomycin-resistant Enterococcus faecium ST1133 in pediatric patients with acute lymphoblastic leukemia from Southern Brazil

Author

Vasconcelos, Thaís Muniz, primary, Mesa, Dany, additional, Rodrigues, Luiza Souza, additional, dos Santos, Érika Medeiros, additional, Krul, Damaris, additional, Siqueira, Adriele Celine, additional, de Abreu, Renata Barbosa Vahia, additional, Motta, Fábio de Araujo, additional, Conte, Danieli, additional, and Dalla-Costa, Libera Maria, additional

Published
2023
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7. ESPECTROSCOPIA DE INFRAVERMELHO COM TRANSFORMADA DE FOURIER (FT-IR) PARA SOROTIPAGEM DE ISOLADOS CLÍNICOS DE STREPTOCOCCUS PNEUMONIAE: ESTUDO PILOTO

Author

Rodrigues, Luiza Souza, primary, de Alencar Siebra, Christian, additional, Krul, Damaris, additional, da Luz, Sthefany Nascimento, additional, da Conceição Barbosa, Sabrina, additional, Vasconcelos, Thaís Muniz, additional, de Araújo Motta, Fábio, additional, and Costa, Libera Maria Dalla, additional

Published
2023
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9. Outbreak of vancomycin-resistant Enterococcus faeciumST1133 in paediatric patients with acute lymphoblastic leukaemia from southern Brazil

Author

Vasconcelos, Thaís Muniz, Mesa, Dany, Rodrigues, Luiza Souza, Medeiros dos Santos, Érika, Krul, Damaris, Siqueira, Adriele Celine, de Abreu, Renata Barbosa Vahia, Motta, Fábio de Araújo, Conte, Danieli, and Dalla-Costa, Libera Maria

Abstract

•ST117 (ST1133) VREfm is circulating in paediatric hospitals, raising concerns.•All VREfm isolates were sensitive to linezolid (4 mg/L).•By the original MLST scheme, all isolates were identified as belonging to ST117.

Published
2024
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10. High-risk clones of carbapenem resistant Klebsiella pneumoniaerecovered from pediatric patients in Southern Brazil

Author

Krul, Damaris, Rodrigues, Luiza Souza, Siqueira, Adriele Celine, Mesa, Dany, dos Santos, Érika Medeiros, Vasconcelos, Thaís Muniz, Spalanzani, Regiane Nogueira, Cardoso, Rodrigo, Ricieri, Marinei Campos, de Araújo Motta, Fábio, Conte, Danieli, and Dalla-Costa, Libera Maria

Abstract

Carbapenem-resistant Klebsiella pneumoniae(CRKP) exhibit high mortality rates in pediatric patients and usually belong to international high-risk clones. This study aimed to investigate the molecular epidemiology and carbapenem resistance mechanisms of K. pneumoniaeisolates recovered from pediatric patients, and correlate them with phenotypical data. Twenty-five CRKP isolates were identified, and antimicrobial susceptibility was assessed using broth microdilution. Carbapenemase production and β-lactamase genes were detected by phenotypic and genotypic tests. Multilocus sequence typing was performed to differentiate the strains and whole-genome sequencing was assessed to characterize a new sequence type. Admission to the intensive care unit and the use of catheters were significantly positive correlates of CRKP infection, and the mortality rate was 36%. Almost all isolates showed multidrug-resistant phenotype, and most frequent resistant gene was blaKPC. We observed the dissemination of ST307 and clones belonging to CG258, which are considered high risk. In pediatric patients, these clones present with high genomic plasticity, favoring adaptation of the KPC and NDM enzymes to healthcare environments.

Published
2024
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12. Invasive Candidiasis in a Pediatric Tertiary Hospital: Epidemiology, Antifungal Susceptibility, and Mortality Rates.

Author

Rodrigues LS, Siqueira AC, Vasconscelos TM, Ferreira AMM, Spalanzani RN, Krul D, Medeiros É, Sestren B, de Almeida Lanzoni L, Ricieri MC, Motta FA, Svidzinski TIE, and Dalla-Costa LM

Abstract

Invasive infections caused by non-albicans Candida are increasing worldwide. However, there is still a lack of information on invasive candidiasis (IC) in the pediatric setting, including susceptibility profiles and clonal studies. We investigated the clinical, epidemiologic, and laboratory characteristics of IC, possible changes in antifungal susceptibility profiles over time, and the occurrence of clonality in our tertiary children's hospital. We analyzed 123 non-duplicate Candida isolates from sterile sites of pediatric patients in a tertiary hospital in southern Brazil, between 2016 and 2021. Data on demographics, comorbidities, and clinical outcomes were collected. Candida species distribution, antifungal susceptibility profiles, biofilm production, and molecular epidemiology of isolates were assessed using reference methods. The range of IC incidence was 0.88-1.55 cases per 1000 hospitalized patients/year, and the IC-related mortality rate was 20.3%. Of the total IC cases, 42.3% were in patients aged < 13 months. Mechanical ventilation, parenteral nutrition, and intensive care unit (ICU) admission were common in this group. In addition, ICU admission was identified as a risk factor for IC-related mortality. The main site of Candida spp. isolation was blood, and non-albicans Candida species were predominant (70.8%). No significant clonal spread was observed among isolates of the three most commonly isolated species, and 99.1% of all isolates were biofilm producers. The incidence of IC and strain susceptibility patterns may vary over time, geographically, and among different populations. Non-albicans Candida species were predominant in this study. Notably, clonal expansion and emergence of antifungal drug resistance were not observed in our pediatric setting., (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)

Published
2024
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