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1. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”

Author

Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Glehen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2023
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2. Dissecting the genetic heterogeneity of gastric cancer

Author

Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Gehlen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2023
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3. Begleitsymptome

Author

Kruschewski, Martin, Hauser, Hubert, editor, Buhr, Heinz Johannes, editor, and Mischinger, Hans-Jörg, editor

Published
2016
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4. Dissecting the genetic heterogeneity of gastric cancer

Author

Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, Schumacher, Johannes, Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, and Schumacher, Johannes

Abstract

Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture. Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO. Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level. Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular me, Errata: Hess, T., Maj, C., Gehlen, J. et. al. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”. eBioMedicine. 2023:94:104709. DOI: 10.1016/j.ebiom.2023.104709

Published
2023
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6. Prognostische Relevanz von p21, p53 und deren Bedeutung als Response-Parameter für die adjuvante Therapie des kolorektalen Karzinoms

Author

Lipka, S., Noske, A., Müller, K., Buhr, H. J., Kruschewski, Martin, Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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7. Mismatch Repair Deficiency, Chemotherapy and Survival for Resectable Gastric Cancer: an Observational Study from the German staR Cohort and a Meta-Analysis

Author

Stolze, Thilo, primary, Franke, Sabine, additional, Haybaeck, Johannes, additional, Moehler, Markus, additional, Grimminger, Peter P., additional, Lang, Hauke, additional, Roth, Wilfried, additional, Gockel, Ines, additional, Kreuser, Nicole, additional, Bläker, Hendrik, additional, Wittekind, Christian, additional, Lordick, Florian, additional, Vieth, Michael, additional, Veits, Lothar, additional, Waidmann, Oliver, additional, Lingohr, Philipp, additional, Peitz, Ulrich, additional, Schildberg, Claus, additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Goni, Elisabetta, additional, Bruns, Christiane J., additional, Ridwelski, Karsten, additional, Wolff, Stefanie, additional, Lippert, Hans, additional, Schumacher, Johannes, additional, Malfertheiner, Peter, additional, and Venerito, Marino, additional

Published
2021
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9. Different Prevalence of Alarm, Dyspeptic and Reflux Symptoms in Patients with Cardia and Non-cardia Gastric Cancer

Author

Franck, Caspar, primary, Zimmermann, Nadja, primary, Goni, Elisabetta, primary, Lippert, Hans, primary, Ridwelski, Karsten, primary, Kruschewski, Martin, primary, Kreuser, Nicole, primary, Lingohr, Philipp, primary, Schildberg, Claus, primary, Vassos, Nikolaos, primary, Waidmann, Oliver, primary, Peitz, Ulrich, primary, Lang, Hauke, primary, Grmminger, Peter P, primary, Bruns, Christiane, primary, Veits, Lothar, primary, Vieth, Michael, primary, Moehler, Markus, primary, Lordick, Florian, primary, Gockel, Ines, primary, Schumacher, Johannes, primary, Malfertheiner, Peter, primary, and Venerito, Marino, primary

Published
2021
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12. Different Prevalence of Alarm, Dyspeptic and Reflux Symptoms in Patients with Cardia and Non-cardia Gastric Cancer

Author

Franck, Caspar, Zimmermann, Nadja, Goni, Elisabetta, Lippert, Hans, Ridwelski, Karsten, Kruschewski, Martin, Kreuser, Nicole, Lingohr, Philipp, Schildberg, Claus, Vassos, Nikolaos, Waidmann, Oliver, Peitz, Ulrich, Lang, Hauke, Grmminger, Peter P., Bruns, Christiane, Veits, Lothar, Vieth, Michael, Moehler, Markus, Lordick, Florian, Gockel, Ines, Schumacher, Johannes, Malfertheiner, Peter, Venerito, Marino, Franck, Caspar, Zimmermann, Nadja, Goni, Elisabetta, Lippert, Hans, Ridwelski, Karsten, Kruschewski, Martin, Kreuser, Nicole, Lingohr, Philipp, Schildberg, Claus, Vassos, Nikolaos, Waidmann, Oliver, Peitz, Ulrich, Lang, Hauke, Grmminger, Peter P., Bruns, Christiane, Veits, Lothar, Vieth, Michael, Moehler, Markus, Lordick, Florian, Gockel, Ines, Schumacher, Johannes, Malfertheiner, Peter, and Venerito, Marino

Abstract

Background & Aims: Symptoms of patients with gastric cancer (GC) are often unspecific and differences in symptoms between patients with cardia and non-cardia GC have been poorly investigated. We aimed to characterize symptoms of patients with cardia and non-cardia GC. Methods: Patients with cardia (Siewert type II and III) and non-cardia GC were recruited in the German multicenter cohort of the Gastric Cancer Research (staR) study between 2013 and 2017. Alarm, dyspeptic and reflux symptoms at the time of presentation were documented using a self-administered questionnaire. Results: A completed self-administered questionnaire was available for 568/759 recruited patients (132 cardia GC, 436 non-cardia GC, male 61%, mean age 64 years). Dyspeptic symptoms were more common in patients with non-cardia GC (69.0 vs. 54.5%, p=0.0024). Cardia GC patients reported more frequently alarm symptoms (69.7 vs. 44.7%, p<0.0001), and were more likely to have Union for International Cancer Control (UICC) stage III-IV (54.1vs. 38.9%, p=0.0034). Especially, dysphagia and weight loss were more common in patients with cardia GC (49.2 vs. 6.4 %, p<0.0001 and 37.1 vs. 25.7%, p=0.02, respectively). No differences between the two groups were observed with respect to reflux symptoms. Patients with alarm symptoms were more likely to have UICC stage III-IV at presentation (69.4 vs. 42.9%, p<0.0001). Conclusions: In clinical practice the symptom pattern at presentation may serve as a hint for tumor localization. Despite the fact that they are common in the general population, dyspeptic symptoms offer a chance for earlier GC detection. Thus, in patients with dyspeptic symptoms who fail empiric approaches, endoscopy should not be delayed.

Published
2021

18. Gastric cancer in autoimmune gastritis: A case-control study from the German centers of the staR project on gastric cancer research

Author

Weise, Friederike, Vieth, Michael, Reinhold, Dirk, Haybaeck, Johannes, Goni, Elisabetta, Lippert, Hans, Ridwelski, Karsten, Lingohr, Philipp, Schildberg, Claus, Vassos, Nikolaos, Kruschewski, Martin, Krasniuk, Iurii, Grimminger, Peter P., Waidmann, Oliver, Peitz, Ulrich, Veits, Lothar, Kreuser, Nicole, Lang, Hauke, Bruns, Christiane, Moehler, Markus, Lordick, Florian, Gockel, Ines, Schumacher, Johannes, Malfertheiner, Peter, Venerito, Marino, Weise, Friederike, Vieth, Michael, Reinhold, Dirk, Haybaeck, Johannes, Goni, Elisabetta, Lippert, Hans, Ridwelski, Karsten, Lingohr, Philipp, Schildberg, Claus, Vassos, Nikolaos, Kruschewski, Martin, Krasniuk, Iurii, Grimminger, Peter P., Waidmann, Oliver, Peitz, Ulrich, Veits, Lothar, Kreuser, Nicole, Lang, Hauke, Bruns, Christiane, Moehler, Markus, Lordick, Florian, Gockel, Ines, Schumacher, Johannes, Malfertheiner, Peter, and Venerito, Marino

Abstract

Objectives Patients with autoimmune gastritis (AIG) are reported to have an increased risk of developing gastric cancer (GC). In this study, we assess the characteristics and outcomes of GC patients with AIG in a multicenter case-control study. Methods Between April 2013 and May 2017, patients with GC, including cancers of the esophagogastric junction (EGJ) Siewert type II and III, were recruited. Patients with histological characteristics of AIG were identified and matched in a 1:2 fashion for age and gender to GC patients with no AIG. Presenting symptoms were documented using a self-administered questionnaire. Results Histological assessment of gastric mucosa was available for 572/759 GC patients. Overall, 28 (4.9%) of GC patients had AIG (67 +/- 9 years, female-to-male ratio 1.3:1). In patients with AIG, GC was more likely to be localized in the proximal (i.e. EGJ, fundus, corpus) stomach (odds ratio (OR) 2.7, 95% confidence interval (CI) 1.0-7.1). In GC patients with AIG, pernicious anemia was the leading clinical sign (OR 22.0, 95% CI 2.6-187.2), and the most common indication for esophagogastroduodenoscopy (OR 29.0, 95% CI 7.2-116.4). GC patients with AIG were more likely to present without distant metastases (OR 6.2, 95% CI 1.3-28.8) and to be treated with curative intention (OR 3.0, 95% CI 1.0-9.0). The five-year survival rates with 95% CI in GC patients with and with no AIG were 84.7% (83.8-85.6) and 53.5% (50.9-56.1), respectively (OR 0.25, 95% CI 0.08-0.75, p = 0.001). Conclusions Pernicious anemia leads to earlier diagnosis of GC in AIG patients and contributes significantly to a better clinical outcome.

Published
2020

22. Gastric cancer in autoimmune gastritis: A case‐control study from the German centers of the staR project on gastric cancer research

Author

Weise, Friederike, primary, Vieth, Michael, additional, Reinhold, Dirk, additional, Haybaeck, Johannes, additional, Goni, Elisabetta, additional, Lippert, Hans, additional, Ridwelski, Karsten, additional, Lingohr, Philipp, additional, Schildberg, Claus, additional, Vassos, Nikolaos, additional, Kruschewski, Martin, additional, Krasniuk, Iurii, additional, Grimminger, Peter P, additional, Waidmann, Oliver, additional, Peitz, Ulrich, additional, Veits, Lothar, additional, Kreuser, Nicole, additional, Lang, Hauke, additional, Bruns, Christiane, additional, Moehler, Markus, additional, Lordick, Florian, additional, Gockel, Ines, additional, Schumacher, Johannes, additional, Malfertheiner, Peter, additional, and Venerito, Marino, additional

Published
2020
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24. Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Author

Heinrichs, Sophie K. M., Hess, Timo, Becker, Jessica, Hamann, Lutz, Vashist, Yogesh K., Butterbach, Katja, Schmidt, Thomas, Alakus, Hakan, Krasniuk, Iurii, Hoeblinger, Aksana, Lingohr, Philipp, Ludwig, Monika, Hagel, Alexander F., Schildberg, Claus W., Veits, Lothar, Gyvyte, Ugne, Weise, Katharina, Schueller, Vitalia, Boehmer, Anne C., Schroeder, Julia, Gehlen, Jan, Kreuser, Nicole, Hofer, Sebastian, Lang, Hauke, Lordick, Florian, Malfertheiner, Peter, Moehler, Markus, Pech, Oliver, Vassos, Nikolaos, Rodermann, Ernst, Izbicki, Jakob R., Kruschewski, Martin, Ott, Katja, Schumann, Ralf R., Vieth, Michael, Mangold, Elisabeth, Gasenko, Evita, Kupcinskas, Limas, Brenner, Hermann, Grimminger, Peter, Bujanda, Luis, Sopena, Federico, Espinel, Jesus, Thomson, Concha, Perez-Aisa, Angeles, Campo, Rafael, Geijo, Fernando, Collette, Daniela, Bruns, Christiane, Messerle, Katharina, Gockel, Ines, Noethen, Markus M., Lippert, Hans, Ridwelski, Karsten, Lanas, Angel, Keller, Gisela, Knapp, Michael, Leja, Marcis, Kupcinskas, Juozas, Garcia-Gonzalez, Maria A., Venerito, Marino, Schumacher, Johannes, Heinrichs, Sophie K. M., Hess, Timo, Becker, Jessica, Hamann, Lutz, Vashist, Yogesh K., Butterbach, Katja, Schmidt, Thomas, Alakus, Hakan, Krasniuk, Iurii, Hoeblinger, Aksana, Lingohr, Philipp, Ludwig, Monika, Hagel, Alexander F., Schildberg, Claus W., Veits, Lothar, Gyvyte, Ugne, Weise, Katharina, Schueller, Vitalia, Boehmer, Anne C., Schroeder, Julia, Gehlen, Jan, Kreuser, Nicole, Hofer, Sebastian, Lang, Hauke, Lordick, Florian, Malfertheiner, Peter, Moehler, Markus, Pech, Oliver, Vassos, Nikolaos, Rodermann, Ernst, Izbicki, Jakob R., Kruschewski, Martin, Ott, Katja, Schumann, Ralf R., Vieth, Michael, Mangold, Elisabeth, Gasenko, Evita, Kupcinskas, Limas, Brenner, Hermann, Grimminger, Peter, Bujanda, Luis, Sopena, Federico, Espinel, Jesus, Thomson, Concha, Perez-Aisa, Angeles, Campo, Rafael, Geijo, Fernando, Collette, Daniela, Bruns, Christiane, Messerle, Katharina, Gockel, Ines, Noethen, Markus M., Lippert, Hans, Ridwelski, Karsten, Lanas, Angel, Keller, Gisela, Knapp, Michael, Leja, Marcis, Kupcinskas, Juozas, Garcia-Gonzalez, Maria A., Venerito, Marino, and Schumacher, Johannes

Abstract

Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 x 10(-04)) and on chromosome 8q24 at rs2585176 (P = 1.09 x 10(-09)). On chromosome 5p13 we found cis-eQTL effects with an up-regulation of PTGER4 expression in GC risk allele carrier (P = 9.27 x 10(-11)). On chromosome 8q24 we observed cis-eQTL effects with an upregulation of PSCA expression in GC risk allele carrier (P = 2.17 x 10(-47)). In addition, we found trans-eQTL effects for the same variants on 8q24 with a downregulation of MBOAT7 expression in GC risk allele carrier (P = 3.11 x 10(-09)). In summary, we confirmed and refined the previously reported GC associations at both chromosomal regions. Our data point to shared etiological factors between Asians and Europeans. Furthermore, our data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring GC pathomechanisms.

Published
2018

25. Evidence for PTGER4 ,PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Author

Heinrichs, Sophie K. M., primary, Hess, Timo, additional, Becker, Jessica, additional, Hamann, Lutz, additional, Vashist, Yogesh K., additional, Butterbach, Katja, additional, Schmidt, Thomas, additional, Alakus, Hakan, additional, Krasniuk, Iurii, additional, Höblinger, Aksana, additional, Lingohr, Philipp, additional, Ludwig, Monika, additional, Hagel, Alexander F., additional, Schildberg, Claus W., additional, Veits, Lothar, additional, Gyvyte, Ugne, additional, Weise, Katharina, additional, Schüller, Vitalia, additional, Böhmer, Anne C., additional, Schröder, Julia, additional, Gehlen, Jan, additional, Kreuser, Nicole, additional, Hofer, Sebastian, additional, Lang, Hauke, additional, Lordick, Florian, additional, Malfertheiner, Peter, additional, Moehler, Markus, additional, Pech, Oliver, additional, Vassos, Nikolaos, additional, Rodermann, Ernst, additional, Izbicki, Jakob R., additional, Kruschewski, Martin, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Vieth, Michael, additional, Mangold, Elisabeth, additional, Gasenko, Evita, additional, Kupcinskas, Limas, additional, Brenner, Hermann, additional, Grimminger, Peter, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Espinel, Jesús, additional, Thomson, Concha, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Geijo, Fernando, additional, Collette, Daniela, additional, Bruns, Christiane, additional, Messerle, Katharina, additional, Gockel, Ines, additional, Nöthen, Markus M., additional, Lippert, Hans, additional, Ridwelski, Karsten, additional, Lanas, Angel, additional, Keller, Gisela, additional, Knapp, Michael, additional, Leja, Marcis, additional, Kupcinskas, Juozas, additional, García-González, Maria A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2018
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26. Gastric Cancer in Autoimmune Gastritis: A Case–Control Study from the Star Project on Gastric Cancer Research

Author

Venerito, Marino, primary, Weise, Friederike, additional, Goni, Elisabetta, additional, Reinhold, Dirk, additional, Ridwelski, Karsten, additional, Lingohr, Philipp, additional, Matthaei, Hanno, additional, Schildberg, Claus, additional, Kruschewski, Martin, additional, Krasniuk, Iurii, additional, Grimminger, Peter P., additional, Moehler, Markus, additional, Wolff, Stefanie, additional, Lippert, Hans, additional, Vieth, Michael, additional, Veits, Lothar, additional, Bruns, Christiane, additional, Lordick, Florian, additional, Gockel, Ines, additional, Malfertheiner, Peter, additional, and Schumacher, Johannes, additional

Published
2017
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28. Ist der Kontinenzerhalt beim primären synchron hepatisch metastasierten Rektumkarzinom gerechtfertigt?

Author

Gröne, Jörn, Joensson, Peer, Zimmermann, Maxie, Buhr, Heinz Johannes, and Kruschewski, Martin

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Bis zu 20% aller Patienten mit primären Rektumkarzinom haben eine synchrone Leber-Metastasierung. Das Ziel war es zu prüfen, ob bei der Resektion des Primärtumors die Kontinenz- oder aber ob aufgrund der fortgeschrittenen Tumorerkrankung primär die risikoärmere[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
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30. Animal experimental trials using rat colitis models

Author

Kruschewski, Martin

Subjects
inflammatory bowel disease, COX-2, endothelin, mitomycin colitis, intravital microscopy, microcirculation, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit, histological scoring system, TNBS colitis
Abstract

Ätiologie und Pathogenese der chronisch entzündlichen Darmerkrankungen, Morbus Crohn und Colitis ulcerosa, sind trotz zahlreicher neuer wissenschaftlicher Erkenntnisse ungeklärt. Das Ziel dieser Arbeit war es, den Stellenwert der Mikrozirkulation in diesem Zusammenhang zu evaluieren. Dazu erfolgten intravitalmikroskopische Untersuchungen am gesunden Darm sowie bei zwei verschiedenen Colitis-Modellen der Ratte. Bei der TNBS-Colitis kommt es im akuten, bei der Mitomycin C-Colitis im chronischen Stadium der Entzündung zu signifikanten Störungen der mukosalen Mikrozirkulation. Schließlich wurden im Rahmen einer Interventionsstudie verschiedene Substanzen appliziert. Es zeigt sich, dass die Gabe des selektiven Endothelin-A-Rezeptor-Antagonisten LU-135252 zu einer signifikanten Besserung sämtlicher Mirkozirkulationsparameter sowie auch der klinischen Befunde gegenüber der Kontroll-TNBS-Colitisgruppe führt. Die Zufuhr des selektiven COX-2-Inhibitors NS-398 hat denselben Effekt, wenn auch nicht so ausgeprägt. Der hemmende Einfluss beider Substanzen auf die Leukozyten–Endothel–Interaktion scheint hierbei eine Rolle zu spielen. Da die Endothelin-A-Rezeptor-Blockade allerdings hinsichtlich der Colitis-Aktivtät signifikant effektiver ist, muss ein weiterer Mechanismus im Sinne einer direkten Wirkung auf den kapillären Blutfluss vorliegen, was die pathogenetische Bedeutung der Mikrozirkulation für die Progression der Colitis unterstreicht., The etiology and pathogenesis of chronic inflammatory bowel disease, Crohn’s disease and ulcerative colitis, remains unclear despite numerous new scientific findings. The aim of this study was to evaluate the role of the microcirculation in this context. For this purpose, intravital microscopic examination of the healthy bowel and in two different rat colitis models was performed. Significant disturbances of the mucosal microcirculation were observed at the acute inflammatory stage of TNBS colitis and at the chronic stage of mitomycin C colitis. Finally, different substances were applied in an intervention study. Application of the selective endothelin-A receptor antagonist LU-135252 resulted in a significant improvement of all microcirculatory parameters and clinical findings compared to the control TNBS colitis group. The same effect, though not as pronounced, was seen with the selective COX-2 inhibitor NS-398. The inhibitory influence of the two substances on leukocyte-endothelium interaction seems to play a role. However, there may be another mechanism like a direct effect on capillary blood flow, since endothelin A receptor blockade is significantly more effective with regard to colitis activity, underscoring the pathogenetic role of the microcirculation on the progression of colitis.

Published
2008
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31. Tu1991 - Gastric Cancer in Autoimmune Gastritis: A Case–Control Study from the Star Project on Gastric Cancer Research

Author

Venerito, Marino, Weise, Friederike, Goni, Elisabetta, Reinhold, Dirk, Ridwelski, Karsten, Lingohr, Philipp, Matthaei, Hanno, Schildberg, Claus, Kruschewski, Martin, Krasniuk, Iurii, Grimminger, Peter P., Moehler, Markus, Wolff, Stefanie, Lippert, Hans, Vieth, Michael, Veits, Lothar, Bruns, Christiane, Lordick, Florian, Gockel, Ines, Malfertheiner, Peter, and Schumacher, Johannes

Published
2017
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35. Epigenetic quantification of tumor-infiltrating T-lymphocytes

Author

Sehouli, Jalid, primary, Loddenkemper, Christoph, additional, Cornu, Tatjana, additional, Schwachula, Tim, additional, Hoffmüller, Ulrich, additional, Grützkau, Andreas, additional, Lohneis, Philipp, additional, Dickhaus, Thorsten, additional, Gröne, Jörn, additional, Kruschewski, Martin, additional, Mustea, Alexander, additional, Turbachova, Ivana, additional, Baron, Udo, additional, and Olek, Sven, additional

Published
2011
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39. Gallbladder Involvement of Henoch-Schönlein Purpura Mimicking Acute Acalculous Cholecystitis.

Author

Hoffmann, Jörg C., Cremer, Philipp, Preiss, Jan C., Ebhardt, Harald, Kruschewski, Martin, Buhr, Heinz-Johannes, and Zeitz, Martin

Subjects
CHOLECYSTITIS, VASCULITIS, ULCERS, ADRENOCORTICAL hormones, CHOLECYSTECTOMY
Abstract

Background/Aims: We report the case of a 53-year-old man with fever and severe abdominal pain following an upper respiratory tract infection. Methods/Results: The clinical signs, the laboratory markers, and the ultrasound findings were consistent with acute acalculous cholecystitis and he underwent cholecystectomy. Histologically the gallbladder showed vasculitis and the patient developed postoperatively a purpuric rash of the legs with transient ankle arthritis. Gastroscopy revealed prepyloric ulcers consistent with vasculitis. The patient was diagnosed as having Henoch-Schönlein purpura. Gastric ulcers as well as arthritis disappeared upon treatment with corticosteroids and proton pump inhibitors. Conclusion: Taken together, Henoch-Schönlein purpura can mimic acute cholecystitis and should be considered as a rare differential diagnosis of acute cholecystitis. Copyright © 2004 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2004
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44. Nosokomiale Pneumonie

Author

Oesterlee, U., Holt, S. K., Schneitler, S., Randerath, W., Schneider, Paul, editor, Kruschewski, Martin, editor, and Buhr, Heinz J., editor

Published
2018
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