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5. NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction: TRANSITION Study

Author

Pascual-Figal, D, Wachter, R, Senni, M, Bao, W, Noe, A, Schwende, H, Butylin, D, Prescott, M, Gniot, J, Mozheiko, M, Lelonek, M, Dominguez, A, Horacek, T, Garcia del Rio, E, Kobalava, Z, Mueller, C, Cavusoglu, Y, Straburzynska-Migaj, E, Slanina, M, vom Dahl, J, Ryding, A, Moriarty, A, Robles, M, Villota, J, Quintana, A, Nitschke, T, Garcia Pinilla, J, Bonet, L, Chaaban, S, Filali zaatari, S, Spinar, J, Musial, W, Abdelbaki, K, Belohlavek, J, Fehske, W, Bott, M, Hoegalmen, G, Leiro, M, Ozcan, I, Mullens, W, Kryza, R, Al-Ani, R, Loboz-Grudzien, K, Ermoshkina, L, Hojerova, S, Fernandez, A, Spinarova, L, Lapp, H, Bulut, E, Almeida, F, Vishnevsky, A, Belicova, M, Witte, K, Wong, K, Droogne, W, Delforge, M, Peterka, M, Olbrich, H, Carugo, S, Nessler, J, Mcgill, T, Huegl, B, Akin, I, Moreira, I, Baglikov, A, Thambyrajah, J, Hayes, C, Barrionuevo, M, Yigit, Z, Kaya, H, Klimsa, Z, Radvan, M, Kadel, C, Landmesser, U, Di Tano, G, Lisik, M, Fonseca, C, Oliveira, L, Marques, I, Santos, L, Lenner, E, Letavay, P, Bueno, M, Mota, P, Wong, A, Bailey, K, Foley, P, Hasbani, E, Virani, S, Massih, T, Al-Saif, S, Taborsky, M, Kaislerova, M, Motovska, Z, Cohen, A, Logeart, D, Endemann, D, Ferreira, D, Brito, D, Kycina, P, Bollano, E, Basilio, E, Rubio, L, Aguado, M, Schiavi, L, Zivano, D, Lonn, E, El Sayed, A, Pouleur, A, Heyse, A, Schee, A, Polasek, R, Houra, M, Tribouilloy, C, Seronde, M, Galinier, M, Noutsias, M, Schwimmbeck, P, Voigt, I, Westermann, D, Pulignano, G, Vegsundvaag, J, Da Silva Antunes, J, Monteiro, P, Stevlik, J, Goncalvesova, E, Hulkoova, B, Castro Fernandez, A, Davies, C, Squire, I, Meyer, P, Sheppard, R, Sahin, T, Sochor, K, De Geeter, G, Schmeisser, A, Weil, J, Soares, A, Bulashova, O, Oshurkov, A, Sunderland, S, Glover, J, Exequiel, T, Decoulx, E, Meyer, S, Muenzel, T, Frioes, F, Arbolishvili, G, Tokarcikova, A, Karlstrom, P, Trullas Vila, J, Perez, G, Sankaranarayanan, R, Nageh, T, Alasia, D, Refaat, M, Demirkan, B, Al-Buraiki, J, Karabsheh, S, Pascual-Figal D., Wachter R., Senni M., Bao W., Noe A., Schwende H., Butylin D., Prescott M. F., Gniot J., Mozheiko M., Lelonek M., Dominguez A. R., Horacek T., Garcia del Rio E., Kobalava Z., Mueller C. E., Cavusoglu Y., Straburzynska-Migaj E., Slanina M., vom Dahl J., Ryding A., Moriarty A., Robles M. B., Villota J. N., Quintana A. G., Nitschke T., Garcia Pinilla J. M., Bonet L. A., Chaaban S., Filali zaatari S., Spinar J., Musial W., Abdelbaki K., Belohlavek J., Fehske W., Bott M. C., Hoegalmen G., Leiro M. C., Ozcan I. T., Mullens W., Kryza R., Al-Ani R., Loboz-Grudzien K., Ermoshkina L., Hojerova S., Fernandez A. A., Spinarova L., Lapp H., Bulut E., Almeida F., Vishnevsky A., Belicova M., Witte K., Wong K., Droogne W., Delforge M., Peterka M., Olbrich H. -G., Carugo S., Nessler J., McGill T. H., Huegl B., Akin I., Moreira I., Baglikov A., Thambyrajah J., Hayes C., Barrionuevo M. R., Yigit Z., Kaya H., Klimsa Z., Radvan M., Kadel C., Landmesser U., Di Tano G., Lisik M. B., Fonseca C., Oliveira L., Marques I., Santos L. M., Lenner E., Letavay P., Bueno M. G., Mota P., Wong A., Bailey K., Foley P., Hasbani E., Virani S., Massih T. A., Al-Saif S., Taborsky M., Kaislerova M., Motovska Z., Cohen A. A., Logeart D., Endemann D., Ferreira D., Brito D., Kycina P., Bollano E., Basilio E. G., Rubio L. F., Aguado M. G., Schiavi L. B., Zivano D. F., Lonn E., El Sayed A., Pouleur A. -C., Heyse A., Schee A., Polasek R., Houra M., Tribouilloy C., Seronde M. F., Galinier M., Noutsias M., Schwimmbeck P., Voigt I., Westermann D., Pulignano G., Vegsundvaag J., Da Silva Antunes J. A., Monteiro P., Stevlik J., Goncalvesova E., Hulkoova B., Castro Fernandez A. J., Davies C., Squire I., Meyer P., Sheppard R., Sahin T., Sochor K., De Geeter G., Schmeisser A., Weil J., Soares A. O., Bulashova O. V., Oshurkov A., Sunderland S. J., Glover J., Exequiel T., Decoulx E., Meyer S., Muenzel T., Frioes F., Arbolishvili G., Tokarcikova A., Karlstrom P., Trullas Vila J. C., Perez G. P., Sankaranarayanan R., Nageh T., Alasia D. C., Refaat M., Demirkan B., Al-Buraiki J., Karabsheh S., Pascual-Figal, D, Wachter, R, Senni, M, Bao, W, Noe, A, Schwende, H, Butylin, D, Prescott, M, Gniot, J, Mozheiko, M, Lelonek, M, Dominguez, A, Horacek, T, Garcia del Rio, E, Kobalava, Z, Mueller, C, Cavusoglu, Y, Straburzynska-Migaj, E, Slanina, M, vom Dahl, J, Ryding, A, Moriarty, A, Robles, M, Villota, J, Quintana, A, Nitschke, T, Garcia Pinilla, J, Bonet, L, Chaaban, S, Filali zaatari, S, Spinar, J, Musial, W, Abdelbaki, K, Belohlavek, J, Fehske, W, Bott, M, Hoegalmen, G, Leiro, M, Ozcan, I, Mullens, W, Kryza, R, Al-Ani, R, Loboz-Grudzien, K, Ermoshkina, L, Hojerova, S, Fernandez, A, Spinarova, L, Lapp, H, Bulut, E, Almeida, F, Vishnevsky, A, Belicova, M, Witte, K, Wong, K, Droogne, W, Delforge, M, Peterka, M, Olbrich, H, Carugo, S, Nessler, J, Mcgill, T, Huegl, B, Akin, I, Moreira, I, Baglikov, A, Thambyrajah, J, Hayes, C, Barrionuevo, M, Yigit, Z, Kaya, H, Klimsa, Z, Radvan, M, Kadel, C, Landmesser, U, Di Tano, G, Lisik, M, Fonseca, C, Oliveira, L, Marques, I, Santos, L, Lenner, E, Letavay, P, Bueno, M, Mota, P, Wong, A, Bailey, K, Foley, P, Hasbani, E, Virani, S, Massih, T, Al-Saif, S, Taborsky, M, Kaislerova, M, Motovska, Z, Cohen, A, Logeart, D, Endemann, D, Ferreira, D, Brito, D, Kycina, P, Bollano, E, Basilio, E, Rubio, L, Aguado, M, Schiavi, L, Zivano, D, Lonn, E, El Sayed, A, Pouleur, A, Heyse, A, Schee, A, Polasek, R, Houra, M, Tribouilloy, C, Seronde, M, Galinier, M, Noutsias, M, Schwimmbeck, P, Voigt, I, Westermann, D, Pulignano, G, Vegsundvaag, J, Da Silva Antunes, J, Monteiro, P, Stevlik, J, Goncalvesova, E, Hulkoova, B, Castro Fernandez, A, Davies, C, Squire, I, Meyer, P, Sheppard, R, Sahin, T, Sochor, K, De Geeter, G, Schmeisser, A, Weil, J, Soares, A, Bulashova, O, Oshurkov, A, Sunderland, S, Glover, J, Exequiel, T, Decoulx, E, Meyer, S, Muenzel, T, Frioes, F, Arbolishvili, G, Tokarcikova, A, Karlstrom, P, Trullas Vila, J, Perez, G, Sankaranarayanan, R, Nageh, T, Alasia, D, Refaat, M, Demirkan, B, Al-Buraiki, J, Karabsheh, S, Pascual-Figal D., Wachter R., Senni M., Bao W., Noe A., Schwende H., Butylin D., Prescott M. F., Gniot J., Mozheiko M., Lelonek M., Dominguez A. R., Horacek T., Garcia del Rio E., Kobalava Z., Mueller C. E., Cavusoglu Y., Straburzynska-Migaj E., Slanina M., vom Dahl J., Ryding A., Moriarty A., Robles M. B., Villota J. N., Quintana A. G., Nitschke T., Garcia Pinilla J. M., Bonet L. A., Chaaban S., Filali zaatari S., Spinar J., Musial W., Abdelbaki K., Belohlavek J., Fehske W., Bott M. C., Hoegalmen G., Leiro M. C., Ozcan I. T., Mullens W., Kryza R., Al-Ani R., Loboz-Grudzien K., Ermoshkina L., Hojerova S., Fernandez A. A., Spinarova L., Lapp H., Bulut E., Almeida F., Vishnevsky A., Belicova M., Witte K., Wong K., Droogne W., Delforge M., Peterka M., Olbrich H. -G., Carugo S., Nessler J., McGill T. H., Huegl B., Akin I., Moreira I., Baglikov A., Thambyrajah J., Hayes C., Barrionuevo M. R., Yigit Z., Kaya H., Klimsa Z., Radvan M., Kadel C., Landmesser U., Di Tano G., Lisik M. B., Fonseca C., Oliveira L., Marques I., Santos L. M., Lenner E., Letavay P., Bueno M. G., Mota P., Wong A., Bailey K., Foley P., Hasbani E., Virani S., Massih T. A., Al-Saif S., Taborsky M., Kaislerova M., Motovska Z., Cohen A. A., Logeart D., Endemann D., Ferreira D., Brito D., Kycina P., Bollano E., Basilio E. G., Rubio L. F., Aguado M. G., Schiavi L. B., Zivano D. F., Lonn E., El Sayed A., Pouleur A. -C., Heyse A., Schee A., Polasek R., Houra M., Tribouilloy C., Seronde M. F., Galinier M., Noutsias M., Schwimmbeck P., Voigt I., Westermann D., Pulignano G., Vegsundvaag J., Da Silva Antunes J. A., Monteiro P., Stevlik J., Goncalvesova E., Hulkoova B., Castro Fernandez A. J., Davies C., Squire I., Meyer P., Sheppard R., Sahin T., Sochor K., De Geeter G., Schmeisser A., Weil J., Soares A. O., Bulashova O. V., Oshurkov A., Sunderland S. J., Glover J., Exequiel T., Decoulx E., Meyer S., Muenzel T., Frioes F., Arbolishvili G., Tokarcikova A., Karlstrom P., Trullas Vila J. C., Perez G. P., Sankaranarayanan R., Nageh T., Alasia D. C., Refaat M., Demirkan B., Al-Buraiki J., and Karabsheh S.

Abstract

Objectives: This study examined the effects of sacubitril/valsartan on N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels and determined patient characteristics associated with favorable NT-proBNP reduction response. Background: NT-proBNP levels reflect cardiac wall stress and predict event risk in patients with acute decompensated heart failure (ADHF). Methods: Post-hoc analysis of the TRANSITION (Comparison of Pre- and Post-discharge Initiation of Sacubitril/Valsartan Therapy in HFrEF Patients After an Acute Decompensation Event) study, including stabilized ADHF patients with reduced ejection fraction, randomized to open-label sacubitril/valsartan initiation in-hospital (pre-discharge) versus post-discharge. NT-proBNP was measured at randomization (baseline), discharge, and 4 and 10 weeks post-randomization. A favorable NT-proBNP response was defined as reduction to ≤1,000 pg/ml or >30% from baseline. Results: In patients receiving sacubitril/valsartan in-hospital, NT-proBNP was reduced by 28% at discharge, with 46% of patients obtaining favorable NT-proBNP reduction response compared with a 4% reduction and 18% favorable response rate in patients initiated post-discharge (p < 0.001). NT-proBNP was reduced similarly in patients initiating sacubitril/valsartan pre- and post-discharge (reduction at 4 weeks: 25%/22%; 10 weeks: 38%/34%) with comparable favorable response rates (46%/42% and 51%/48% at 4 and 10 weeks, respectively). NT-proBNP favorable response at 4 weeks was associated with lower risk of first heart failure (HF) rehospitalization or cardiovascular death through 26 weeks (hazard ratio: 0.57; 95% confidence interval [CI]: 0.38 to 0.86; p = 0.007). Predictors of a favorable response at 4 weeks were starting dose ≥49/51 mg twice daily, higher baseline NT-proBNP, lower baseline serum creatinine, de novo HF, no atrial fibrillation, angiotensin-converting enzyme inhibitor–naive or angiotensin receptor blocker–naive, and no prior myocardial inf

Published
2020

6. NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction: TRANSITION Study

Author

Pascual-Figal D., Wachter R., Senni M., Bao W., Noe A., Schwende H., Butylin D., Prescott M. F., Gniot J., Mozheiko M., Lelonek M., Dominguez A. R., Horacek T., Garcia del Rio E., Kobalava Z., Mueller C. E., Cavusoglu Y., Straburzynska-Migaj E., Slanina M., vom Dahl J., Ryding A., Moriarty A., Robles M. B., Villota J. N., Quintana A. G., Nitschke T., Garcia Pinilla J. M., Bonet L. A., Chaaban S., Filali zaatari S., Spinar J., Musial W., Abdelbaki K., Belohlavek J., Fehske W., Bott M. C., Hoegalmen G., Leiro M. C., Ozcan I. T., Mullens W., Kryza R., Al-Ani R., Loboz-Grudzien K., Ermoshkina L., Hojerova S., Fernandez A. A., Spinarova L., Lapp H., Bulut E., Almeida F., Vishnevsky A., Belicova M., Witte K., Wong K., Droogne W., Delforge M., Peterka M., Olbrich H. -G., Carugo S., Nessler J., McGill T. H., Huegl B., Akin I., Moreira I., Baglikov A., Thambyrajah J., Hayes C., Barrionuevo M. R., Yigit Z., Kaya H., Klimsa Z., Radvan M., Kadel C., Landmesser U., Di Tano G., Lisik M. B., Fonseca C., Oliveira L., Marques I., Santos L. M., Lenner E., Letavay P., Bueno M. G., Mota P., Wong A., Bailey K., Foley P., Hasbani E., Virani S., Massih T. A., Al-Saif S., Taborsky M., Kaislerova M., Motovska Z., Cohen A. A., Logeart D., Endemann D., Ferreira D., Brito D., Kycina P., Bollano E., Basilio E. G., Rubio L. F., Aguado M. G., Schiavi L. B., Zivano D. F., Lonn E., El Sayed A., Pouleur A. -C., Heyse A., Schee A., Polasek R., Houra M., Tribouilloy C., Seronde M. F., Galinier M., Noutsias M., Schwimmbeck P., Voigt I., Westermann D., Pulignano G., Vegsundvaag J., Da Silva Antunes J. A., Monteiro P., Stevlik J., Goncalvesova E., Hulkoova B., Castro Fernandez A. J., Davies C., Squire I., Meyer P., Sheppard R., Sahin T., Sochor K., De Geeter G., Schmeisser A., Weil J., Soares A. O., Bulashova O. V., Oshurkov A., Sunderland S. J., Glover J., Exequiel T., Decoulx E., Meyer S., Muenzel T., Frioes F., Arbolishvili G., Tokarcikova A., Karlstrom P., Trullas Vila J. C., Perez G. P., Sankaranarayanan R., Nageh T., Alasia D. C., Refaat M., Demirkan B., Al-Buraiki J., Karabsheh S., Pascual-Figal, D, Wachter, R, Senni, M, Bao, W, Noe, A, Schwende, H, Butylin, D, Prescott, M, Gniot, J, Mozheiko, M, Lelonek, M, Dominguez, A, Horacek, T, Garcia del Rio, E, Kobalava, Z, Mueller, C, Cavusoglu, Y, Straburzynska-Migaj, E, Slanina, M, vom Dahl, J, Ryding, A, Moriarty, A, Robles, M, Villota, J, Quintana, A, Nitschke, T, Garcia Pinilla, J, Bonet, L, Chaaban, S, Filali zaatari, S, Spinar, J, Musial, W, Abdelbaki, K, Belohlavek, J, Fehske, W, Bott, M, Hoegalmen, G, Leiro, M, Ozcan, I, Mullens, W, Kryza, R, Al-Ani, R, Loboz-Grudzien, K, Ermoshkina, L, Hojerova, S, Fernandez, A, Spinarova, L, Lapp, H, Bulut, E, Almeida, F, Vishnevsky, A, Belicova, M, Witte, K, Wong, K, Droogne, W, Delforge, M, Peterka, M, Olbrich, H, Carugo, S, Nessler, J, Mcgill, T, Huegl, B, Akin, I, Moreira, I, Baglikov, A, Thambyrajah, J, Hayes, C, Barrionuevo, M, Yigit, Z, Kaya, H, Klimsa, Z, Radvan, M, Kadel, C, Landmesser, U, Di Tano, G, Lisik, M, Fonseca, C, Oliveira, L, Marques, I, Santos, L, Lenner, E, Letavay, P, Bueno, M, Mota, P, Wong, A, Bailey, K, Foley, P, Hasbani, E, Virani, S, Massih, T, Al-Saif, S, Taborsky, M, Kaislerova, M, Motovska, Z, Cohen, A, Logeart, D, Endemann, D, Ferreira, D, Brito, D, Kycina, P, Bollano, E, Basilio, E, Rubio, L, Aguado, M, Schiavi, L, Zivano, D, Lonn, E, El Sayed, A, Pouleur, A, Heyse, A, Schee, A, Polasek, R, Houra, M, Tribouilloy, C, Seronde, M, Galinier, M, Noutsias, M, Schwimmbeck, P, Voigt, I, Westermann, D, Pulignano, G, Vegsundvaag, J, Da Silva Antunes, J, Monteiro, P, Stevlik, J, Goncalvesova, E, Hulkoova, B, Castro Fernandez, A, Davies, C, Squire, I, Meyer, P, Sheppard, R, Sahin, T, Sochor, K, De Geeter, G, Schmeisser, A, Weil, J, Soares, A, Bulashova, O, Oshurkov, A, Sunderland, S, Glover, J, Exequiel, T, Decoulx, E, Meyer, S, Muenzel, T, Frioes, F, Arbolishvili, G, Tokarcikova, A, Karlstrom, P, Trullas Vila, J, Perez, G, Sankaranarayanan, R, Nageh, T, Alasia, D, Refaat, M, Demirkan, B, Al-Buraiki, J, and Karabsheh, S

Subjects
Heart Failure, acute decompensated heart failure, Aminobutyrates, Biphenyl Compounds, Aftercare, Stroke Volume, TRANSITION study, Patient Discharge, Peptide Fragments, Angiotensin Receptor Antagonists, Drug Combinations, sacubitril/valsartan, Natriuretic Peptide, Brain, Humans, Valsartan, heart failure with reduced ejection fraction, N-terminal pro–B-type natriuretic peptide
Abstract

Objectives: This study examined the effects of sacubitril/valsartan on N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels and determined patient characteristics associated with favorable NT-proBNP reduction response. Background: NT-proBNP levels reflect cardiac wall stress and predict event risk in patients with acute decompensated heart failure (ADHF). Methods: Post-hoc analysis of the TRANSITION (Comparison of Pre- and Post-discharge Initiation of Sacubitril/Valsartan Therapy in HFrEF Patients After an Acute Decompensation Event) study, including stabilized ADHF patients with reduced ejection fraction, randomized to open-label sacubitril/valsartan initiation in-hospital (pre-discharge) versus post-discharge. NT-proBNP was measured at randomization (baseline), discharge, and 4 and 10 weeks post-randomization. A favorable NT-proBNP response was defined as reduction to ≤1,000 pg/ml or >30% from baseline. Results: In patients receiving sacubitril/valsartan in-hospital, NT-proBNP was reduced by 28% at discharge, with 46% of patients obtaining favorable NT-proBNP reduction response compared with a 4% reduction and 18% favorable response rate in patients initiated post-discharge (p < 0.001). NT-proBNP was reduced similarly in patients initiating sacubitril/valsartan pre- and post-discharge (reduction at 4 weeks: 25%/22%; 10 weeks: 38%/34%) with comparable favorable response rates (46%/42% and 51%/48% at 4 and 10 weeks, respectively). NT-proBNP favorable response at 4 weeks was associated with lower risk of first heart failure (HF) rehospitalization or cardiovascular death through 26 weeks (hazard ratio: 0.57; 95% confidence interval [CI]: 0.38 to 0.86; p = 0.007). Predictors of a favorable response at 4 weeks were starting dose ≥49/51 mg twice daily, higher baseline NT-proBNP, lower baseline serum creatinine, de novo HF, no atrial fibrillation, angiotensin-converting enzyme inhibitor–naive or angiotensin receptor blocker–naive, and no prior myocardial infarction. Conclusions: In-hospital initiation of sacubitril/valsartan produced rapid reductions in NT-proBNP, statistically significant at discharge. A favorable NT-proBNP response over time was associated with a better prognosis and predicted by higher starting dose and predisposing clinical profile. (Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event [TRANSITION]; NCT02661217)

Published
2020

7. Early Palaeozoic initial-rift volcanism in the Central European Variscides (the Kaczawa Mountains, Sudetes, SW Poland): evidence from SIMS dating of zircons

Author

Kryza, R., Zalasiewicz, J.A., Mazur, S., Aleksandrowski, P., Sergeev, S., and Presnyakov, S.

Subjects
Europe -- Natural history, Volcanism -- Research, Chronology -- Methods, Zircon -- Properties, Faults (Geology) -- Research, Earth sciences
Abstract

Early Palaeozoic volcanic suites are widespread throughout the Variscan Belt, and have commonly been ascribed to incipient rifling along the northern periphery of Gondwana in Cambrian to Ordovician times. Their distribution across Europe defines the present-day extent of Gondwana-derived terranes and constrains the timing of their separation from the Gondwanan margin. The Kaczawa Mountains in the West Sudetes, at the eastern termination of the Variscan Belt, include bimodal rift-related rocks, but their protolith age and, hence, their significance have been highly uncertain. We have applied secondary ionization mass spectrometry zircon geochronology to a metarhyodacite and a metatrachyte from this suite, yielding ages of 502.4 [+ or -] 2.6 Ma and 485.7 [+ or -] 1.6 Ma, respectively. This constrains the initial rift magmatism to c. 500-485 Ma in this part of the European Variscides. The rift-related Early Palaeozoic volcanism thus seems to have been broadly synchronous throughout the peri-Gondwanan terranes of Europe.

Published
2007

11. New U-Pb monazite and zircon data from the Sudetes Mountains in SW Poland: evidence for a single-cycle Variscan orogeny

Author

Timmermann, H., Parrish, R.R., Noble, S.R., and Kryza, R.

Subjects
Poland -- Natural history, Geology -- Research, Geological time -- Research, Earth sciences
Abstract

New U-Pb monazite and zircon data combined with a study of their internal morphologies significantly clarifies the controversy surrounding the Palaeozoic geodynamic evolution of the Sudetes Mountains in the northeastern Bohemian Massif. Variably thin rims of secondary magmatic overgrowth on zircons from an anatectic granite in the Gory Sowie block are dated by a U-Pb zircon lower intercept age of 353 [+ or -] 61 Ma, by magmatic monazite growth at 378 [+ or -] 2 Ma, and by xenotime crystallization at 383-370 Ma in a late syntectonic pegmatite, reflecting the anatectic event associated with a single-cycle Variscan orogeny in this area. Keywords: Sudetes, Variscan orogeny, geochronology, monazite, zircon.

Published
2000

12. Kinematic data on major Variscan strike-slip faults and shear zones in the Polish Sudetes, northeast Bohemian Massif

Author

Aleksandrowski, P., Kryza, R., Mazur, S., and Zaba, J.

Subjects
Poland -- Natural history, Kinematics -- Research, Faults (Geology) -- Research, Shear (Mechanics) -- Research, Rocks -- Research, Earth sciences
Abstract

The still highly disputable terrane boundaries in the Sudetic segment of the Variscan belt mostly seem to follow major strike-slip faults and shear zones. Their kinematics, expected to place important constraints on the regional structural models, is discussed in some detail. The most conspicuous is the WNW-ESE Intra-Sudetic Fault Zone, separating several different structural units of the West Sudetes. It showed ductile dextral activity and, probably, displacement magnitude of the order of tens to hundreds kilometres, during late Devonian(?) to early Carboniferous times. In the late Carboniferous (to early Permian?), the sense of motion on the Intra-Sudetic Fault was reversed in a semi-brittle to brittle regime, with the left-lateral offset on the fault amounting to single kilometres. The north-south trending Niemcza and northeast-southwest Skrzynka shear zones are left-lateral, ductile features in the eastern part of the West Sudetes. Similarly oriented (northeast-southwest to NNE-SSW) regional size shear zones of as yet undetermined kinematics were discovered in boreholes under Cenozoic cover in the eastern part of the Sudetic foreland (the Niedzwiedz and Nysa-Brzeg shear zones). One of these is expected to represent the northern continuation of the major Stare Mesto Shear Zone in the Czech Republic, separating the geologically different units of the West and East Sudetes. The Rudawy Janowickie Metamorphic Unit, assumed in some reconstructions to comprise a mostly strike-slip terrane boundary, is characterized by ductile fabric developed in a thrusting regime, modified by a superimposed normal-slip extensional deformation. Thrusting-related deformational fabric was locally reoriented prior to the extensional event and shows present-day strike-slip kinematics in one of the sub-units. The Sudetic Boundary Fault, although prominent in the recent structure and topography of the region, was not active as a Variscan strike-slip fault zone. The reported data emphasize the importance of syn-orogenic strike-slip tectonics in the Sudetes. The recognized shear sense is compatible with a strike-slip model of the northeast margin of the Bohemian Massif, in which the Kaczawa and Gory Sowie Units underwent late Devonian-early Carboniferous southeastward long-distance displacement along the Intra-Sudetic Fault Zone from their hypothetical original position within the Northern Phyllite Zone and the Mid-German Crystalline High of the German Variscides, respectively, and were juxtaposed with units of different provenance southwest of the fault. The Intra-Sudetic Fault Zone, together with the Elbe Fault Zone further south, were subsequently cut in the east and their eastern segments were displaced and removed by the younger, early to late Carboniferous, NNE-SSW trending, transpressional Moldanubian-Stare Mesto Shear Zone.

Published
1997

13. Geochemical evidence for progressive, rift-related early Palaeozoic volcanism in the western Sudetes

Author

Furnes, H., Kryza, R., Muszynski, A., Pin, C., and Garmann, L.B.

Subjects
Sudetenland -- Natural history, Volcanism -- Research, Geology, Stratigraphic -- Paleozoic, Petrology -- Research, Petrofabric analysis -- Research, Rifts (Geology) -- Research, Earth sciences
Abstract

The volcanigenic rocks of the Kaczawa Mts (western Sudetes, Poland), in the eastern Variscides, show changing geological and geochemical evolution during early Palaeozoic time. The lower part of the succession (Cambrian (?)-Ordovician) has three components. 1. Shallow marine to subaerial metabasalts, associated with limestones and volcaniclastics. The lavas are dominantly of a transitional tholeiitic-alkaline type and their trace element patterns typically represent a rift-related environment. They pass laterally (and upwards ?) into more depleted basalts resembling enriched MORB, with Nd-isotopic characteristics indicating contamination by continental crust. 2. Interlayered rhyodacitic lavas and volcaniclastics which show negative Epsilon(sub Nd) values, suggesting formation of the original magma by crustal melting. 3. An overlying alkaline bimodal suite of lavas and volcaniclastic rocks, as well as alkaline metabasites of shallow-intrusive character. The geochemistry of the latter resembles oceanic island volcanics, but they may well have been emplaced in the same evolving rift environment. The upper part of the Kaczawa succession, Ordovician-Silurian (?) in age, comprises a thick and monotonous sequence of deep-marine pillowed and massive metabasalts, associated with black shales and cherts. These lavas exhibit MORB trace element characteristics, with minor evidence of crustal contamination. During this stage of rifting, true oceanic crust probably formed. It is thus suggested that the studied part of the Kaczawa succession developed in a progressively evolving rift, initially within an ensialic environment, and finally reaching the stage of a basin underlain by oceanic-type crust. Together with similar Cambrian-Ordovician volcanic-sedimentary associations, widely distributed in western Europe, from Portugal, through France and Germany, they represent a record of the Early Palaeozoic rifting in the northern periphery of Gondwana.

Published
1994

15. Evolocumab and clinical outcomes in patients with cardiovascular disease

Author

Sabatine, Marc S., Giugliano, Robert P., Keech, Anthony C., Honarpour, Narimon, Wiviott, Stephen D., Murphy, Sabina A., Kuder, Julia F., Wang, Huei, Liu, Thomas, Wasserman, Scott M., Sever, Peter S., Pedersen, Fish MP, Terje R., Abrahamsen, Te, Im, K, Kanevsky, E, Bonaca, Mp, Lira Pineda, A, Hanlon, K, Knusel, B, Somaratne, R, Kurtz, C, Scott, R, Accini Mendoza JL, Amerena, J, Badariene, J, Burgess, L, Ceska, R, Charng, Mj, Choi, D, Cobos, Jl, Dan, Ga, De Ferrari GM, Deedwania, Pc, Chopra, Vk, Erglis, A, Ezhov, Mv, Ferreira, J, Filipová, S, Gaciong, Za, Pasierski, T, Georgiev, Bg, Gonzalez-Galvez, G, Gouni-Berthold, I, Schäufele, T, Hirayama, A, Huber, K, Rammer, M, Kjaerulf Jensen, H, Wermuth, S, Jiang, L, Jukema, Jw, Kraydashenko, O, Leiter, La, Lewis, Bs, López-Miranda, J, Lorenzatti, Aj, Mach, F, Mcadam, B, Nilsson, L, Olsson, Å, Rallidis, L, Rogelio, Gg, Kerr Saraiva JF, Scheen, A, Schiele, F, Scott, Rs, Connolly, D, Siu, Cw, Tay, L, Thorgeirsson, G, Tikkanen, Mj, Tokgozoglu, Sl, 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Tahirkheli, N, Delgado, E, Derian, W, Greenwald, J, Harris, M, Jackson, R, Marhefka, G, Mcelveen, W, Mooss, A, Morris, P, Murray, J, Pearlstein, P, Raisinghani, A, Rezkalla, S, Sakhrani, L, Schreibman, D, Shaoulian, E, Steinsapir, J, Yataco, A, De La Cruz, A, Fredrick, M, Goldenberg, E, Lee, D, Mccullum, K, Mclellan, B, Stephens, L, Wilson, S, Alfieri, A, Mandviwala, M, Orourke, D, Samal, A, Schmedtje, J, Waxman, F, Carhart, R, Clements, B, Dyke, C, Ghali, J, Gruberg, L, Hack, T, Jehle, A, Pogue, B, Schooley, C, and Shifrin, G

Subjects
Male, STATIN THERAPY, 2700 General Medicine, Disease, Cardiovascular, PLACEBO-CONTROLLED TRIAL, Gastroenterology, 0302 clinical medicine, Anticholesteremic Agent, Medicine, Myocardial infarction, 11 Medical and Health Sciences, ddc:616, Incidence, Antibodies, Monoclonal, General Medicine, Cholesterol, Cardiovascular Diseases, Monoclonal, Drug Therapy, Combination, Proprotein Convertase 9, Antibody, Aged, Anticholesteremic Agents, Atherosclerosis, Cholesterol, LDL, Double-Blind Method, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Least-Squares Analysis, Middle Aged, Medicine (all), REDUCING LIPIDS, Human, medicine.medical_specialty, Evinacumab, Clinical Trials and Supportive Activities, PCSK9 INHIBITION, Follow-Up Studie, LDL, 03 medical and health sciences, Drug Therapy, Clinical Research, LDL-C, Least-Squares Analysi, Science & Technology, Unstable angina, PCSK9, medicine.disease, chemistry, Clinical Biochemistry, 030204 cardiovascular system & hematology, Bococizumab, FOURIER Steering Committee and Investigators, Medical and Health Sciences, chemistry.chemical_compound, Antibodies monoclonal, Cardiovascular Disease, 030212 general & internal medicine, Stroke, Humanized, RISK, biology, PCSK9 Inhibitors, 10051 Rheumatology Clinic and Institute of Physical Medicine, Heart Disease, Atherosclerosi, 6.1 Pharmaceuticals, Combination, Cardiology, Life Sciences & Biomedicine, Antibodies, Monoclonal, Humanized, EZETIMIBE, 610 Medicine & health, Antibodies, Medicine, General & Internal, General & Internal Medicine, Internal medicine, CORONARY-HEART-DISEASE, In patient, Heart Disease - Coronary Heart Disease, Alirocumab, Ldl cholesterol, business.industry, Evaluation of treatments and therapeutic interventions, Evolocumab, Good Health and Well Being, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, biology.protein, MODERATE, Hydroxymethylglutaryl-CoA Reductase Inhibitor, business
Abstract

Background Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin–kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. Methods We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. Results At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P

Published
2017

16. Evolocumab and clinical outcomes in patients with cardiovascular disease

Author

Sabatine, M. S., Giugliano, R. P., Keech, A. C., Honarpour, N., Wiviott, S. D., Murphy, S. A., Kuder, J. F., Wang, H., Liu, T., Wasserman, S. M., Sever, P. S., Pedersen, T. R., Fish, M. P., Abrahamsen, T. E., Im, K., Kanevsky, E., Bonaca, M. P., Lira Pineda, A., Hanlon, K., Knusel, B., Somaratne, R., Kurtz, C., Scott, R., Accini Mendoza, J. L., Amerena, J., Badariene, J., Burgess, L., Ceska, R., Charng, M. J., Choi, D., Cobos, J. L., Dan, G. A., De Ferrari, G. M., Deedwania, P. C., Chopra, V. K., Erglis, A., Ezhov, M. V., Ferreira, J., Filipova, S., Gaciong, Z. A., Pasierski, T., Georgiev, B. G., Gonzalez-Galvez, G., Gouni-Berthold, I., Schaufele, T., Hirayama, A., Huber, K., Rammer, M., Kjaerulf Jensen, H., Wermuth, S., Jiang, L., Jukema, J. W., Kraydashenko, O., Leiter, L. A., Lewis, B. S., Lopez-Miranda, J., Lorenzatti, A. J., Mach, F., Mcadam, B., Nilsson, L., Olsson, A., Rallidis, L., Rogelio, G. G., Kerr Saraiva, J. F., Scheen, A., Schiele, F., Connolly, D., Siu, C. W., Tay, L., Thorgeirsson, G., Tikkanen, M. J., Tokgozoglu, S. L., Toth, K., Viigimaa, M., Wan Ahmad, W. A., Hennekens, C. H., Andreotti, F., Baigent, C., Brown, W. V., Davis, B. R., Newcomer, J. W., Wood, S. K., Larosa, J., Ansell, B., Lowe, C., Zahn, L., Awtry, E., Berger, C., Croce, K., Desai, A., Gelfand, E., Ho, C., Leeman, D., Link, M., Norden, A., Pande, A., Rost, N., Ruberg, F., Silverman, S., Singhal, A., Vita, J., Mackinnon, I., Vogel, D. R., Leon de la Fuente, R., Perna, E., Amuchastegui, M., Pacora, F., Hershson, A., Blumberg, E., Glenny, J. A., Colombo, H., Cuadrado, J. A., Nicolosi, L., Rojas, C. G., Ulla, M. R., Hasbani, E. G., Cuneo, C., Lopez Santi, R. G., Sanabria, H. D., Hrabar, A., Lozada, A., Begg, A., Lehman, S., Wittert, G., Juergens, C., Kostner, K., Beltrame, J., Simpson, R., Sinhal, A., Adams, M., Kritharides, L., Roberts Thomson, P., Cross, D., Thompson, P., Van Gaal, W., Cox, N., Farshid, A., Hammett, C., Garrahy, P., Prasan, A., Horrigan, M., Ebenbichler, C., Hanusch, U., Prager, R., Schernthaner, G., Luger, A., Siostrzonek, P., Toplak, H., Bergler-Klein, J., Paulweber, B., Sinzinger, H., Buysschaert, I., Thoeng, J., Vandekerckhove, H., Catez, E., Verheye, S., Descamps, O., Hoffer, E., Wollaert, B., Chenu, P., van de Borne, P., De Meulemeester, M., Friart, A., Charlier, F., De Raedt, H., Rietzschel, E., Roelandt, R., Lalmand, J., Tavares Russo, L. A., Reis, G., Duarte Barbosa, E. C., Vidotti, M. H., Fernandes Manenti, E. R., Dutra, O., Leaes, P. E., Rech, R. L., Bertolim Precoma, D., Nicolau, J. C., Amoedo, R., Eliaschewitz, F. G., Pereira, A., Kurtz Lisboa, H. R., Soares Piegas, L., Cunha Borges, J. L., Ferreira Rossi, P. R., Pimentel Filho, P., Bodanese, L. C., de Sa Cunha, R., Moura Jorge, J. C., Ardito, W. R., Barroso de Souza, W. K., Hissa, M., Izar, M. C., Manolova, A., Kitova, L., Kinova, E., Tzekova, M., Velchev, V., Tarnovska-Kadreva, R., Gotchev, D., Petrov, I., Raev, D., Trendafilova-Lazarova, D., Yotov, Y., Lazov, P., Rahimi, S., St Amour, E., Constance, C., Pesant, Y., Hess, A., Anderson, T., Sussex, B., Henein, S., Tsoukas, G., Pandey, A. S., Bergeron, J., Hart, R., Gosselin, G., Chehayeb, R., Hamet, P., Hartleib, M., Mukherjee, A., Halperin, F., Petrella, R., Bhargava, R., Lonn, E., Sabbah, E., Bata, I., Cha, J., Gaudet, D., Chapman, K., Murthy, D., Nigro, F., Rupka, D., Gossard, D., Gupta, M., Dowell, A., Mansour, S., Baass, A., Geadah, C., Huynh, T., Peterson, S., Poirier, P., Sabe-Affaki, G., Vertes, G., Crowley, D., Duchesne, L., Pincetti Jofre, C. P., Potthoff Cardenas, S., Conejeros Kindel, C., Saavedra Gajardo, V. A., Lanas Zanetti, F., Sepulveda Varela, P. A., Stockins Fernandez, B. A., Li, W., Li, D., Zhao, S., Li, Z., Wang, J., Yang, Y., Zhang, L., Yang, P., Zhang, X., Huang, H., Xue, L., Zheng, Z., Huang, W., Dai, H., Su, H., Zeng, X., Zheng, Y., Tang, Y., Yao, Z., Sun, Y., Du, Y., Ge, Z., Yan, J., Chen, X., Liu, F., Pei, H., Yang, X., Cui, H., Gu, Y., Yang, Z., Li, J., Lian, Y., Cui, Y., Wang, D., Jiang, J., Li, X., Chen, J., Mo, Z., Xu, P., He, Y., Zhou, C., Qu, P., Zhu, Y., Liu, Y., Shen, X., Gao, X., Terront Lozano, M. A., Moncada Corredor, M. A., Hernandez Triana, E., Botero Lopez, R., Coronel Arroyo, J. A., Quintero Baiz, A. E., Sanchez Vallejo, G., Arana Londono, C., Molina de Salazar, D. I., Castellanos Bueno, R., Manzur Jattin, F., Cure Cure, C. A., Sotomayor Herazo, A., Spinar, J., Hala, T., Machkova, M., Klimsa, Z., Polasek, R., Jerabek, O., Kazdera, P., Pozdisek, Z., Vaclavik, J., Frana, P., Elbl, L., Kucera, D., Kryza, R., Malecha, J., Reichert, P., Sochor, K., Ludka, O., Kellnerova, I., Peterka, K., Zidkova, E., Cech, V., Brabec, T., Fiserova, N., Kvasnicka, J., Rosolova, H., Nemecek, E., Adamkova, V., Dunaj, M., Pojsl, S., Cepelak, M., Podpera, I., Kuchar, L., Rysava, D., Burianova, H., Spinarova, L., Skrobakova, J., Charvat, J., Homza, M., Zemanek, J., Koleckar, P., Karen, I., Krupicka, J., Blaha, V., Matuska, J., Brotanek, J., Cifkova, R., Kuchar, R., Vomacka, Z., Kosek, Z., Hulinsky, V., Krejcova, H., Kuchar, J., Jelinek, Z., Jelinek, P., Markdanner Lindgren, L., Saetre Lihn, A., Korsgaard Thomsen, K., Bronnum-Schou, J., Nielsen, H., Nielsen, T., Egstrup, K., Klausen, I. C., Mickley, H., Hove, J., Jeppesen, J., Melchior, T., Schmidt, E. B., Valter, I., Rosenthal, A., Kaik, J., Kork, A., Alt, I., Strand, J., Nieminen, S., Kahri, J., Suomi, J., Nyman, K., Strandberg, T. E., Piippo, T., Savolainen, M., Vikman, S., Pucheu, Y., Cariou, B., Henry, P., Ferrari, E., Montalescot, G., Ferrieres, J., Roubille, F., Bonnet, B., Angoulvant, D., Range, G., Bammert, A., Delarche, N., Mariat, C., Cayla, G., Durlach, V., Coisne, D., Paillard, F., Rouzier, R., Goralski, M., Khanoyan, P., Cottin, Y., Ziegler, O., Khalife, K., Le Corvoisier, P., Motreff, P., Spaulding, C., Vanbelle, E., Bourhaial, H., Opitz, C., Kahrmann, G., Contzen, C., Appel, K., Schenkenberger, I., Rinke, A., Trenk, D., Maus, O., Karakas, M., Hanefeld, M., Darius, H., Hetzel, G., Munzel, T., Wohrle, J., Stawowy, P., Marten, I., Isermann, B., Kast, P., Vorpahl, M., Bosiljanoff, P., Hengstenberg, C., Kassner, U., Salbach, P., Fischer, M., Steiner, S., Wagner, S., Kraatz, U., von Hodenberg, E., Weyland, K., Mantas, I., Tziakas, D., Bousboulas, S., Patsilinakos, S., Mertzanos, G., Panagoulis, C., Bilianou, H., Skoumas, I., Elisaf, M., Manolis, A., Moschos, N., Kochiadakis, G., Ntaios, G., Richter, D., Athyros, V., Kolovou, G., Danias, P., Melidonis, A., Fan, K. Y. Y., Siu, S. C., Hornyik, A., Lakatos, F., Zilahi, Z., Nagy, K., Laszlo, Z., Peterfai, E., Lupkovics, G., Andreka, P., Merkely, B., Herczeg, B., Piros, G. A., Salamon, C., Mark, L., Papp, A., Szakal, I., Edes, I., Mohacsi, A., Tomcsanyi, J., Hajko, E., Nagy, A., Papp, E., Kiss, R., Karadi, I., Sigurdsson, A., Jain, A., Pai, R., Kothiwale, V., Kulkarni, G., Mahajan, A., Aggarwal, S., Mehta, V., Rajadhyaksha, G., Joshi, A., Khandait, V., Parmar, M., Tyagi, S., Airody Govinda, R., Dwivedi, S. K., Parikh, K., Pothineni, R. B., Solanki, B., O'Donnell, M., Crean, P., Barton, J., Shechter, M., Shotan, A., Klutstein, M., Chorin, E., Gavish, D., Kracoff, O., Atar, S., Rigler, S., Hasin, Y., Schiff, E., Merlini, P., Rapezzi, C., Pirro, M., Gonnelli, S., Floresta, A. M., Mennuni, M., Ardissino, D., Senni, M., Marenzi, G., Marcucci, R., Sampietro, T., Cosmi, F., Perrone Filardi, P., De Caterina, R., Fedele, F., Moretti, L., Biasucci, Luigi Marzio, Ferri, C., Go, Y., Kiyosue, A., Higashi, Y., Tokunaga, T., Kawasaki, T., Sakagami, S., Namba, S., Saku, K., Oku, K., Arakawa, T., Iida, H., Nakamura, Y., Yamamoto, K., Hata, Y., Katsuda, Y., Koga, Y., Shimizu, M., Uehara, H., Kajiyama, S., Okamoto, H., Shinozaki, T., Fujino, Y., Funazaki, T., Higa, N., Kaigawa, K., Koike, A., Nakane, H., Sato, K., Satoh, Y., Shirasawa, K., Sugino, H., Tanabe, J., Uemura, O., Yoshimichi, G., Akai, A., Himeno, H., Inage, T., Inoko, M., Kadokami, T., Noguchi, Y., Yamashita, K., Yasumura, Y., Yuge, M., Hosokawa, S., Kawamitsu, K., Kozuma, K., Matsuo, H., Nakashima, E., Okada, M., Wada, A., Yokoya, K., Iwade, K., Kawabata, K., Tanno, H., Ako, J., Fujita, H., Izumiya, Y., Kanno, M., Nunohiro, T., Ohmura, H., Ueno, T., Kakurina, N., Jasinkevica, I., Stukena, I., Veze, I., Eglite, R., Teterovska, D., Sime, I., Strazdiene, V., Venceviciene, L., Gustiene, O., Radzeviciene-Jurgute, R., Kucinskiene, A., Maskon, O., Lee, C. Y., Erng, T., Gan, H. W., Mohamed Yusof, A. K., Ramanathan, G. L., Liew, H., Lopez Alvarado, A., Nevarez Ruiz, L. A., De los Rios Ibarra, M. O., Bazzoni Ruiz, A. E., Ramos Lopez, G. A., Llamas Esperon, G. A., De la Pena Topete, G. D. J., Violante Ortiz, R. M., Illescas Diaz, J. J., Leon Gonzalez, S., Sanchez Diaz, C. J., Mendez Machado, G. F., Venegas Carrillo, L. A., Aldrete Velasco, J. A., Cardona Munoz, E. G., Leiva Pons, J. L., Perez Alva, J. C., van der Zwaan, C., Oomen, A., van de Wal, R., Magro, M., Boswijk, D., Janus, C., Groutars, R., Tonino, W., Cornel, J. H., Oude Ophuis, A., Troquay, R., Liem, A., Westendorp, I., Van Hessen, M., Lok, D., De Nooijer, C., Den Hartog, F., Van Beek, E., Bendermacher, P., Jansen, R., Romer, T., Rensing, B., Hersbach, F., Herrman, J., Ladyjanskaia, G., Karalis, I., Linssen, G., Bokern, M., Visman, A., Kooij, A., Monajemi, H., Lieverse, A., Baker, J., Tie, S., Risberg, K., Hysing, J., Hoivik, H. O., Norheim, P., Solnor, L., Hovland, A., Kjaernli, T., Jocson, G., Coching, R. M., Batalla, E., Go, A., Habaluyas, R., Barcinas, R., Sy, R. A., Estepar, R. A., Germar, A., Trebacz, J., Szymkowiak, K., Wnetrzak-Michalska, R., Kopaczewski, J., Przekwas-Jaruchowska, M., Kania, G., Zabowka, M., Mirek-Bryniarska, E., Dabrowska, M., Napora, P., Konieczny, M., Spyra, J., Lysek, R., Pijanowski, Z., Grzegorzewski, B., Bednarkiewicz, Z., Kinasz, L., Antkowiak-Piatyszek, K., Stania, K., Szpajer, M., Staneta, P., Skonieczny, G., Ksiezycka-Majczynska, E., Blicharski, T., Piepiorka, M., Wozakowska-Kaplon, B., Zechowicz, T., Ilkowski, J., Lubiszewska, B., Hiczkiewicz, J., Wierzbicka, K., Kosior, D., Garbocz, P., Kubica, J., Raczak, G., Wozniak, I., Cygler, J., Kramarczuk, E., Bystryk, L., Pentela-Nowicka, J., Dabrowski, M., Podolec, P., Zieba, B., Mosiewicz, J., Dubaniewicz, W., Banach, M., Tyszecka, G., Lepich, T., Rychlewska-Hanczewska, A., Guzik, T., Monteiro, P., Pereira, H., Oliveira, L., Matos, P., Soares Goncalves, S., Leitao, A., Vasco Salgado, A., Timoteo, A. T., Pintilei, E., Badila, E., Militaru, C., Tudoran, M., Arsenescu-Georgescu, C., Mitu, F., Zdrenghea, D., Lighezan, D., Teodorescu, I., Popescu, M. I., Coman, I., Vintila, M. M., Vishnevsky, A., Lukyanov, Y., Blokhin, A., Kostenko, V., Shvarts, Y., Markov, V., Motylev, I., Dronov, D., Sherenkov, A., Barbarash, O., Shutemova, E., Bolshakova, O., Kobalava, Z., Voevoda, M., Treshkur, T., Zrazhevskiy, K., Pimenov, L., Solovev, O., Tarasov, N., Arkhipov, M., Freidlin, M., Shalaev, S., Yakhontova, P., Shustov, S., Goloshchekin, B., Panov, A., Bart, B., Bubnova, M., Gordeev, I., Osipova, I., Tereshenko, S., Solovieva, E., Meshkov, A., Zateyshchikov, D., Tan, J. L., Subramaniam, T., Pella, D., Fulop, P., Antalik, L., Dzupina, A., Banikova, A., Sosovec, D., Urgeova, L., Mazur, J., Hranai, M., Banik, M., Vinanska, D., Lennerova, J., Kovar, F., Pastrnakova, E., Uhliar, R., Blasko, P., Gonsorcik, J., Lukacova, J., Oriesek, R., Hatalova, K., du Toit, M., Ebrahim, I., Vawda, G., Lipschitz, S., Blignaut, S., Engelbrecht, J., Coetzer, T. F., Pretorius, M., Urbach, D., Badat, A., Pillay, S., Van Zyl, L., Abelson, M., van der Walt, E., Moodley, R., Jacovides, A., Oosthuysen, W. M., Klug, E., Lottering, H., Kok, J., Saaiman, J., Dawood, S., De Jong, D. M., Kapp, C., Makotoko, E., Bayat, J., Sarvan, M., Vally, T., Stapelberg, A., Kim, M., Bae, J., Cho, Y., Kim, S., Han, K. H., Her, S., Kim, B., Lee, S., Hong, B., Kim, W., Rha, S., Jeong, M., Shin, G. J., Vida Gutierrez, M., Valdes Chavarri, M., Pinto Sala, X., Gonzalez Juanatey, J. R., Civeira Murillo, F., Zamorano Gomez, J. L., Lekuona Goya, I., Iniguez Romo, A., Cordero Fort, A., Ascaso Gimilio, J. F., Millan Nunez-Cortes, J., Lindholm, C., Soderberg, S., Suutari, A., Berglund, S., Mooe, T., Kusiak, D., Bandh, S., Dahlen, G., Olsson, S., Witt, N., Tyden, P., Johansson, P., Cizinsky, S., Falck, G., Pettersson, S. I., Rasmanis, G., Ostergren, J., Moccetti, T., Beer, H. J., Eberli, F., Krahenbuhl, S., Linka, A., Ackermann, D., Michel, P., Yeh, H., Tsai, C. F., Wu, C., Hsia, C., Juang, J., Hsieh, I., Lai, W., Huang, C., Hsieh, Y., Sahin, T., Duzenli, M., Yigit, Z., Demir, M., Yilmaz, M. B., Muderrisoglu, I. H., Kirma, C., Ercan, E., Kayikcioglu, L., Balbay, Y., Lymar, I., Kulynych, O., Prokhorov, O., Karpenko, O., Vakaliuk, I., Stanislavchuk, M., Korzh, O., Rudyk, I., Zhurba, S., Svishchenko, Y., Tseluyko, V., Gyrina, O., Reshotko, D., Kopytsya, M., Volkov, V., Myshanych, G., Rebrov, B., Rishko, M., Rudenko, L., Shatylo, V., Parkhomenko, O., Yena, L., Golovchenko, O., Sorokina, I., Malynovsky, Y., Ivan, P., Blagden, M., Dear, H., Mathew, A., Lagocki, S., Kondagunta, V., Ahsan, A., Mckinnon, C., Douglas, F., Thom, S., Fiore, G., Caulfield, M., Lynch, M., Thomas, H., Bain, S., Hall, A., Mcnally, D., Fisher, M., Keeling, P., Al-Bahrani, A., Lip, G., Ellery, A., Purohit, J., Travill, C., Cappuccio, F., Davis, G., Gaunt, R., Adlam, D., Asamoah, N., Jaafar, F., Mccormack, T., Jupp, B., Pye, M., Ainsworth, P., Chauhan, A., Paul, N., Fairlie, H., Fox, C., Muzulu, S., Trevelyan, J., Aggarwal, R., Issa, B., Saravanan, P., Cruickshank, K., Gorog, D., Heller, S., Newby, D., Nicolson, A., Hare, P. O., Donnelly, P., Rutherfurd, S., de Belder, M., Finlayson, J., Harvey, J., Hoye, A., Kingston, D., Sarkar, D., Negahban, A., Webster, J., Wyatt, N., Muir, S., Cummings, M., Mackenzie, I., Senior, R., Capps, N., Fotherby, K., Mcintyre, H., Aldegather, J., Dixon, L., Saksena, R., Butler, R., Ramstad, D., Pierpont, B., Levinson, D., Mohammed, A., Haddad, T., Goel, A., Dave, K., Haught, W. 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O., Donnelly, P., Rutherfurd, S., de Belder, M., Finlayson, J., Harvey, J., Hoye, A., Kingston, D., Sarkar, D., Negahban, A., Webster, J., Wyatt, N., Muir, S., Cummings, M., Mackenzie, I., Senior, R., Capps, N., Fotherby, K., Mcintyre, H., Aldegather, J., Dixon, L., Saksena, R., Butler, R., Ramstad, D., Pierpont, B., Levinson, D., Mohammed, A., Haddad, T., Goel, A., Dave, K., Haught, W. H., Desire, A., Hershon, K., Napoli, M., Tami, L., Rothschild, R., Khurana, S., Gupta, D., Cheung, D., Hearne, S., Grubb, S., Miller, A., Baird, I., Marcus, A., Srivastava, S., Forgosh, L., Fritz, R., Mays, M., Bertolet, B., Reddy, J., Khan, M., Nakhle, S., Dill, S., Fishbein, G., Khan, B., Marais, H., Reschak, M., Malone, M., Nadar, V., Whitney, R., Reichman, A., Reyes, H., El Shahawy, M., Rabinowitz, A., Weinstein, D., Farhat, N., Onyema, D., Potu, R., Runquist, L., Barnum, O., Crater, T., Fialkow, J., Shah, A., Thompson, C., Wiseman, A., Doyle, T., Henderson, D., Herzog, W., Schnitzler, R., Carr, K., Davis, M., Nagajothi, N., Olsen, S., Rogers, W., Rubino, J., Singh, I., Tarleton, G., Bhagwat, R., Clardy, D., Jardula, M., Robinson, J., Torres, M., Vijay, N., Farris, N., Lillo, J., Moriarty, P., Recknor, C., Berlacher, P., Christensen, T., Gabra, N., Issa, M., Janik, M., Lawless, A., Molter, D., Stout, E., Brezina, B., Claxton, E., Linsky, R., Poock, J., Remler, R., Roseman, H., Schramm, E., Al-Joundi, T., Amin, J., Hitchcock, J., Isserman, S., Kirstein, J., Rider, J., Shalek, M., Sherman, H., Bernstein, M., Chandra, L., Hatharasinghe, R., Ibrahim, H., Iteld, B., Linzmeyer, K., Seaton, B., Zeig, S., Christofides, E., Dunbar, R., Griffin, S., Kohli, N., Koren, M., Pharr, W., Purdy, D., Spencer, R., Yeoman, G., Banerjee, S., Cheek, H. B., Engel, E., Hamroff, G., Huling, R., Kozlowski, L., Levin, P., Makam, S., Meengs, M., Bhushan, R., Erickson, B., Herman, L., Lo, E., Mcdowell, E., Mcgrew, F., Miller, M., Ord, J., Webel, R., Wilhoit, G., Wise, J., Yang, E., Budoff, M., Collins, J., Dauber, I., Dobkin, L., Focil, A., Gandy, W., Pasquini, J., Ramos, M., Rodriguez, D., Rosenson, R., Sanford, K., Schlau, A., Snyder, B., Stonesifer, L., Tang, A., De Souza, J., Elam, M., French, J., Guyton, J., Hage Korban, E., Kereiakes, D., King, M., Loh, I., Navarro, J., Simons, R., Tobin, T., Younis, L., Aboufakher, R., Baldari, D., Ballantyne, C., Broughton, R., Eaton, C., Johnston, J., Simon, W., Thomson, S., Vora, K., Youngman, D., Alzohaili, O., Auerbach, E., Brown, C., Burrough, B., Chen, Y., Gilpatrick, M., Landzberg, J., Mitchell, C., Rice, L., Rubenfire, M., Sofley, C. W., Strobl, D., Atassi, K., Davila, W., Diogo, J., Fagan, T., Joffe, I., Krishna, J., Osea, E., Penny, W., Rowe, W., Shapiro, M., Welker, J., Benton, R., Dobratz, D., Fortuin, F., Graham, J., Henry, B., Kusnick, B., Lutskiy, M., Mcrae, A., Saway, W., Scott, J., Shah, M., Weinberg, B., Zarich, S., Acheatel, R., Case, C., Earl, J., Fernandez, S., Giugliano, G., Handelsman, Y., Hermany, P., Holder, S., Kashyap, M., Khan, A., Lader, E., Peniston, J., Raoof, T., Sacco, J., Shore, K., Spriggs, D., Stringam, S., Tahirkheli, N., Delgado, E., Derian, W., Greenwald, J., Harris, M., Jackson, R., Marhefka, G., Mcelveen, W., Mooss, A., Morris, P., Murray, J., Pearlstein, P., Raisinghani, A., Rezkalla, S., Sakhrani, L., Schreibman, D., Shaoulian, E., Steinsapir, J., Yataco, A., De La Cruz, A., Fredrick, M., Goldenberg, E., Lee, D., Mccullum, K., Mclellan, B., Stephens, L., Wilson, S., Alfieri, A., Mandviwala, M., Orourke, D., Samal, A., Schmedtje, J., Waxman, F., Carhart, R., Clements, B., Dyke, C., Ghali, J., Gruberg, L., Hack, T., Jehle, A., Pogue, B., Schooley, C., Shifrin, G., and Biasucci L. M. (ORCID:0000-0002-6921-6497)

Abstract

BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reacti

Published
2017

17. Deciphering the geochronology of a large granitoid pluton (Karkonosze Granite, SW Poland): an assessment of U-Pb zircon SIMS and Rb-Sr whole-rock dates relatives to U-Pb zircon CA-ID-TIMS

Author

Kryza, R., Pin, Christian, Oberc-Dziedzic, T., Q.G., Crowley, Larionov, A., Institute of Geological Sciences [Wrocław] (UWr), University of Wrocław [Poland] (UWr), Laboratoire Magmas et Volcans (LMV), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Trinity College Dublin, A.P.Karpinsky All-Russian Geological Research Institute (VSEGEI), Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Variscan Karkonosze Granite, Granitoids, [SDU]Sciences of the Universe [physics], ID-TIMS, U-Pb zircon dating, Chemical abrasion, Rb-Sr isotopes, Re-Os dating, ComputingMilieux_MISCELLANEOUS, SHRIMP, Short-lived versus protracted magmatic evolution
Abstract

International audience

Published
2014
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19. Metals in tortula muralis from sandstone buildings in an urban agglomeration

Author

Kosior, G., Prell, M., Samecka-Cymerman, A., Stankiewicz, A., Kolon, K., Kryza, R., Brudzińska-Kosior, A., Frontasyeva, M., Kempers, A.J., Kosior, G., Prell, M., Samecka-Cymerman, A., Stankiewicz, A., Kolon, K., Kryza, R., Brudzińska-Kosior, A., Frontasyeva, M., and Kempers, A.J.

Abstract

Contains fulltext : 142462.pdf (Publisher’s version ) (Closed access)

Published
2015

20. The diversity and geodynamic significance of Late Cambrian (ca. 500 Ma) felsic anorogenic magmatism in the northern part of the Bohemian Massif: A review based on Sm-Nd isotope and geochemical data

Author

Pin, Christian, Kryza, R., Oberc-Dziedzic, T., Mazur, S., Turniak, K., Waldhausrovvá, Jarmila, Laboratoire Magmas et Volcans (LMV), Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
fertility, granitoids, partial melting, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, A-type, geochemistry
Abstract

International audience; Ca. 500 Ma orthogneisses and bimodal suites are widespread along the northern part of the Bohemian Massif (central European Variscides) and are interpreted to document intense magmatism during a continental break-up episode along the northern periphery of Gondwana. Based on geological setting, and geochemical and isotopic evidence, these felsic igneous rocks record the generation of: (1) magmas of pure or predominantly crustal derivation, represented by minor extrusives and much more voluminous orthogneisses similar to S-type granitoids; (2) subordinate magmas of exclusively mantle origin (ranging from within-plate alkali trachytes to oceanic plagiogranites) corresponding to felsic derivatives of associated basalts; and (3) magmas of hybrid origin, produced either as a result of large degrees of contamination of mantle-derived magmas ascending through the crust, or alternatively, generated by partial melting of mixed sources, such as interlayered sediments and mafic rocks or graywackes containing a juvenile component. The high-temperature dehydration melting process responsible for the generation of the most abundant rock-types necessitated the advection of mantle heat, in a context of continental lithosphere extension, as documented by broadly coeval basaltic magmatism at the scale of the igneous province. The large volumes of felsic magmas generated during the 500-Ma anorogenic event are interpreted to result from the combination of a hot extensional tectonic regime with the widespread availability in the lower crust of fertile lithologies, such as metagraywackes. This in turn reflects the largely undifferentiated nature of the crustal segment accreted some 50–100 m.y. earlier during the Cadomian orogeny.

Published
2007
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22. Palaeozoic amalgamation of Central Europe: new results from recent geological and geophysical investigations

Author

Winchester, J., Floyd, P., Crowley, Q., Piasecki, M., Lee, M., Pharaoh, T., Williamson, P., Banka, D., Verniers, J., Samuelsson, J., Bayer, U., Marotta, A., Lamarche, J., Franke, W., Dorr, W., Valverde-Vaquero, P., Giese, U., Vecoli, M., Thybo, H., Laigle, M., Scheck, M., Maluski, H., Marheine, D., Noble, S., Paarish, R., Evans, J., Timmerman, H., Gerdes, A., Guterch, A., Grad, M., Cwojdzinski, S., Cymerman, Z., Kozdroj, W., Kryza, R., Alexandrowski, P., Mazur, S., Stedra, V., Kotkova, J., Belka, Z., Patocka, F., Kachlik, V., and 4.4 Basin Analysis, 4.0 Chemistry and Material Cycles, Departments, GFZ Publication Database, Deutsches GeoForschungsZentrum

Subjects
geography, geography.geographical_feature_category, Orocline, Paleozoic, 550 - Earth sciences, Geophysics, Massif, Devonian, Baltica, Suture (geology), East European Craton, Geology, Earth-Surface Processes, Terrane
Abstract

Multidisciplinary studies of geotransects across the North European Plain and Southern North Sea, and geological reexamination of the Variscides of the North Bohemian Massif, permit a new 3-D reassessment of the relationships between the principal crustal blocks abutting Baltica along the Trans-European Suture Zone (TESZ). Accretion was in three stages: Cambrian accretion of the Bruno–Silesian, Lysogory and Malopolska terranes; end-Ordovician/early Silurian accretion of Avalonia; and early Carboniferous accretion of the Armorican Terrane Assemblage (ATA). Palaeozoic plume-influenced metabasite geochemistry in the Bohemian Massif explains the progressive rifting away of peri-Gondwanan crustal blocks before their accretion to Baltica. Geophysical data, faunal and provenance information from boreholes, and dated small inliers and cores confirm that Avalonian crust extends beyond the Anglo-Brabant Deformation Belt eastwards to northwest Poland. The location and dip of reflectors along the TESZ and beneath the North European Plain suggest that Avalonian crust overrode the Baltica passive margin, marked by a high-velocity lower crustal layer, on shallowly southwest-dipping thrust planes forming the Heligoland–Pomerania Deformation Belt. The “Variscan orocline” of southwest Poland masks two junctions between the Armorican Terrane Assemblage (ATA) and previously accreted crustal blocks. To the east is a dextrally transpressive contact with the Bruno–Silesian and Malopolska blocks, accreted in the Cambrian, while to the north is a thrust contact with easternmost Avalonia, deeply buried beneath younger sedimentary cover. In the northeast Bohemian and Rhenohercynian Massifs Devonian “early Variscide” deformation dominated by WNW and NW-directed thrusting, records closure of Ordovician–Devonian seaways between detached “islands” of the ATA and Avalonia.

Published
2002

41. Safety of early discharge in low risk patients after acute ST-segment elevation myocardial infarction, treated with primary percutaneous coronary intervention. Open label, randomized trial.

Author

Novobilsky K, Stipal R, Cerny P, Horak I, Kaucak V, Mrozek J, Vaclavik J, and Kryza R

Subjects
Aged, Female, Humans, Male, Monitoring, Physiologic, Prospective Studies, ST Elevation Myocardial Infarction physiopathology, Time Factors, Treatment Outcome, Continuity of Patient Care standards, Length of Stay statistics & numerical data, Patient Discharge standards, Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction surgery
Abstract

Background: The length of hospital stay in patients with acute myocardial infarction and ST-segment elevation (STEMI) has been shortened in recent years with corresponding savings in costs, but there is limited available data on its implementation in clinical practice. The aim of this trial was to determine whether early discharge in selected patients after STEMI is feasible and safe., Methods: 151 patients with STEMI successfully treated with primary percutaneous coronary intervention (PCI) who fulfilled the inclusion criteria of low risk were randomly assigned to two groups on a 1:1 ratio: early (within 48-72 h of admission) and standard (after 72 h) discharge. The primary end point was the composite of death, myocardial infarction (MI), unstable angina, stroke, unplanned rehospitalization, repeated target vessel revascularization and stent thrombosis at 90 days after discharge. The study is registered with ClinicalTrials.gov (identifier NCT02023983)., Results: The primary end point occurred in 5 patients in the early group and 6 in the standard group (6.6% vs. 8.0%, P=0.765). There were no significant differences in the incidence of individual components of the primary end point at 90 days. The length of hospital stay was significantly shorter in the intervention group (60.8 ± 8.5 vs. 92.1 ± 12.1 h, P<0.0001)., Conclusion: This study confirms that early discharge within 48-72 h in selected low risk patients after STEMI treated with successful primary PCI is feasible and safe, with outcomes comparable to the later discharge. This strategy applies to more than a quarter of all STEMI patients.

Published
2019
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42. CT-guided brachytherapy (CTGB) versus interstitial laser ablation (ILT) of colorectal liver metastases: an intraindividual matched-pair analysis.

Author

Pech M, Wieners G, Kryza R, Dudeck O, Seidensticker M, Mohnike K, Redlich U, Rühl R, Wust P, Gademann G, and Ricke J

Subjects
Aged, Disease Progression, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Liver Neoplasms radiotherapy, Liver Neoplasms surgery, Male, Matched-Pair Analysis, Middle Aged, Brachytherapy methods, Colorectal Neoplasms radiotherapy, Colorectal Neoplasms surgery, Image Processing, Computer-Assisted methods, Laser Therapy methods, Liver Neoplasms secondary, Radiotherapy, Computer-Assisted methods, Tomography, X-Ray Computed methods
Abstract

Purpose: To compare local tumor control after percutaneous tumor ablation by interstitial laser therapy (ILT) or CT-guided brachytherapy (CTGB)., Patients and Methods: In a matched pair analysis including 18 patients with 36 liver metastases of colorectal primary, both ILT and CTGB were performed in different lesions. The following matching factors were considered: (i) tumor size < or = 5 cm, and (ii) execution of chemotherapy after tumor ablation. Primary endpoint was local tumor control., Results: Treated lesions were identical in terms of tumor size and all matching criteria were fulfilled in all patients except for the performance of adjuvant chemotherapy. Median follow-up was 14 months (3-24 months) for both groups. Only five of 18 patients (28%) demonstrated local tumor progression after CTGB, whereas in ten of 18 patients (56%) tumor progression was found after ILT. Differences encountered were significant for all patients (p = 0.04), whereas in those who fulfilled all matching criteria (n = 14) the level of statistical significance was not reached (p = 0.23)., Conclusion: CTGB demonstrated superior local tumor control compared to ILT in long-term follow-up.

Published
2008
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