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2. Synthesis of oleanolic acid analogues targeting PDGF receptor inhibitors and their antitumor biological activities.

Author

Meng, Yan-Qiu, Zhou, Ying, Li, Qian-Wen, Tong, Si-Miao, Kuai, Zheng-Yu, and Li, Xiao-Xiao

Subjects
STEROIDS analysis, CELL proliferation, ANTINEOPLASTIC agents, CELL lines, CELL receptors, CHEMICAL processes, MOLECULAR structure, PLATELET-derived growth factor, RESEARCH funding, STEROIDS, THIN layer chromatography, IN vitro studies, MOLECULAR docking, FLUORESCENCE polarization immunoassay, PHARMACODYNAMICS
Abstract

The PDGF receptor is mock-coupled with a known active compound, and 14 novel skeleton candidate compounds were designed and synthesized. The structure was confirmed by 1H NMR, 13C NMR and MS. The in vitro cytotoxicity of the two cancer cell lines (SGC-7901 and A549) was evaluated by MTT assay. PDGF receptor protein inhibition assays were performed on I6 and II4 using fluorescence polarization immunoassay (FPIA). [ABSTRACT FROM AUTHOR]

Published
2021
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