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Cuili Kuang, Yunfei ZhaRadiological Department, Renmin Hospital of Wuhan University, Hubei, People’s Republic of ChinaCorrespondence: Yunfei ZhaRadiological Department, Renmin Hospital of Wuhan University, No.99 ZhangZhiDong Road, Wuchang District, Wuhan, Hubei 430060, People’s Republic of ChinaTel +86 135 5406 1833Email fskyanteam@126.comPurpose: We employed resting-state fMRI analyses to reveal central functional reorganization in the brains of patients with cervical spondylotic myelopathy (CSM) and to provide complementary evidence of cortex reorganization in these patients.Patients and methods: We obtained Fisher’s z transformation amplitude of low-frequency fluctuations (zALFF) and Fisher’s z transformation regional homogeneity (zReHo) measurements from 33 patients with CSM and 33 healthy controls (HC) and used the brain regions with significant alterations in the zALFF or zReHo values as seed regions. Then, we calculated Pearson’s correlation coefficients between the resting-state time courses of each seed and the time series of the rest of the brain. Lastly, we computed correlations between the altered zALFF, zReHo, and functional connectivity with Japanese Orthopaedic Association scores, Neck Disability Index score, and the duration of symptoms in patients with CSM.Results: zALFF and zReHo values were increased in the left medial superior frontal gyrus (lSFGmed) and left supramarginal gyrus (lSMG) in patients with CSM compared with those in the HC group. Selecting lSFGmed as the seed, we observed increased functional connectivity between it and the left postcentral gyrus (lPoCG) and left rolandic operculum and decreased functional connectivity with the right medial superior frontal gyrus in patients with CSM. In addition, there was a significant increase in the functional connectivity between the lSMG (seed) and the left calcarine and lPoCG in patients with CSM. However, we did not find any significant correlation between the resting-state findings and the clinical performance of patients with CSM.Conclusion: These observed intrinsic functional changes in the patients with CSM may be related to functional reorganization and reflect the innate cortical plasticity in patients with CSM. Notably, the increased connectivity between the lPoCG and the two seed ROIs indicates the adaptive changes in patients with CSM. These findings provide complementary evidence of cortex reorganization in CSM.Keywords: ALFF, ReHo, seed-based functional connectivity, cervical spondylotic myelopathy

Deep learning (DL)–based algorithms to determine prostate cancer (PCa) Grade Group (GG) on biopsy slides have not been validated by comparison to clinical outcomes. We used a DL-based algorithm, AIRAProstate, to regrade initial prostate biopsies in 2 independent PCa active surveillance (AS) cohorts. In a cohort initially diagnosed with GG1 PCa using only systematic biopsies (n = 138), upgrading of the initial biopsy to ≥GG2 by AIRAProstate was associated with rapid or extreme grade reclassification on AS (odds ratio = 3.3, P  =  .04), whereas upgrading of the initial biopsy by contemporary uropathologist reviews was not associated with this outcome. In a contemporary validation cohort that underwent prostate magnetic resonance imaging before initial biopsy (n = 169), upgrading of the initial biopsy (all contemporary GG1 by uropathologist grading) by AIRAProstate was associated with grade reclassification on AS (hazard ratio = 1.7, P  =  .03). These results demonstrate the utility of a DL-based grading algorithm in PCa risk stratification for AS. [ABSTRACT FROM AUTHOR]

Inhalation of airborne fibers such as asbestos has been a concern for toxicological response that can affect lung tissues. This study aims at developing a computational model that predicts experimental measurements for fibrous particle filtration in nylon mesh screens and elucidates the physics underlying particle dynamics. The filtration process is operated at the constant airflow of 7 cm/s for particles with aerodynamic diameters between 0.8 and 10 μm corresponding to the particle length between 11.4 and 54.3 μm and particle diameter between 0.6 and 8.5 μm. The aerodynamic diameter characterizes particle sizes having different shapes and densities with a single dimension. This two-dimensional (2D) computational model with a single fiber represents the infinite array of screen fibers parallel to each other and screen collection efficiency is estimated by a previously proposed formula taking into account particle laden flow crossing two crossed fibers. The orientations of fibrous particles in a three-dimensional form are projected to the 2D plane and analyzed in the cross-sectional view of a screen. The simulations generally well predict experimental profiles of the screen collection efficiency as a function the aerodynamic diameter and screen pore size. The analyses carried out contain the distribution of particle fraction deposited along fiber surface, particle pathlines, particle distribution in the gas flow, and breakdown of forces acting on a single particle. [ABSTRACT FROM AUTHOR]

The susceptibility of air quality, weather, terrestrial ecosystems, and climate to human activities was investigated in a tropical environment.

For the development of new energy automobile industry and the trend of automobile lightweight have put forward a huge demand for high-strength lightweight materials, so developing high strength aluminum alloys is particularly momentous. As the most widely used aluminum alloy, 6000 series aluminum alloys (Al–Mg–Si alloys) have the advantages such as better mechanical properties, outstanding welding properties, excellent formability and fine processing capability, and therefore have obtained great attention as the structural materials. In addition, the Al–Mg–Si alloys with low density and corrosion resistance not only reduce the total weight of the car, but also extend the service life when subjected to chemical corrosion, which effectively achieve energy saving and emission reduction. This paper summarizes the research progress of 6000 series aluminum alloys, in particular, and reviews the methods of microalloying and particle strengthening, and their effects on the microstructure and properties of the alloy, thus providing a reference for the subsequent development of high-performance aluminum alloys in automobile and aerospace industries.

Rapid growth in industrial sectors such as automotive and shipbuilding has highlighted the significance of strip casting technology to produce lightweight alloys, particularly aluminum alloys widely used in both industrial production and daily life. Twin-roll casting (TRC), as an economically and environmentally friendly method for slab/strip production and processing, has attracted significant interest from researchers. However, the development of TRC aluminum alloys faces many challenges due to limited understanding of microstructural characteristics and control mechanisms. To further enhance comprehension of TRC aluminum alloys, this article reviews the influencing parameters, control methods, and existing issues related to TRC sub-rapid solidification (SRS) microstructure. It firstly summarizes TRC equipment types and their solidification characteristics, followed by a detailed analysis on key parameters affecting the evolution of TRC microstructure including rolling speed, roll separation force (RSF), and heat transfer coefficient (HTC). Finally, solutions to TRC defects are summarized and evaluated alongside their underlying mechanisms. This article provides a comprehensive review of the characteristics and control mechanisms of TRC microstructure while offering valuable insights for the future production of high-quality TRC aluminum strips.

In the global pursuit of energy conservation, reduction in consumption and emissions, as well as lightweighting, 5xxx-series aluminum alloys have emerged as a promising lightweight and high-strength material with a wide range of applications in aerospace, transportation, building structures, medical devices, and more. However, it is worth noting that 5XXX-series aluminum alloys belong to a category of non-heat-treatable reinforced aluminum alloys with limited means of enhancing their properties through heat treatment. Consequently, the development of high-performance 5XXX-series aluminum alloys poses a significant challenge. This paper provides an overview of the research progress on 5xxx-series aluminum alloys while discussing the current state of research regarding the influence of microalloying elements on their microstructure and properties. Furthermore, it elucidates the emerging trends in synergistic regulation between deformation processes and heat treatment processes for enhancing organizational refinement and improving alloy properties. Additionally, this study analyzes the reinforcement mechanism responsible for the exceptional properties exhibited by 5xxx-series aluminum alloys. Lastly, it discusses the exceptional properties exhibited by 5xxx-series alloys along with their primary areas of application. The findings presented herein can serve as a valuable reference for future advancements in advanced high-performance 5xxx-series aluminum alloys.