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3. Efficacy of Burosumab in Adults with X-linked Hypophosphatemia (XLH): A Post Hoc Subgroup Analysis of a Randomized Double-Blind Placebo-Controlled Phase 3 Study

Author

Brandi, Maria Luisa, Jan de Beur, Suzanne, Briot, Karine, Carpenter, Thomas, Cheong, Hae Il, Cohen-Solal, Martine, Crowley, Rachel K., Eastell, Richard, Imanishi, Yasuo, Imel, Erik A., Ing, Steven W., Insogna, Karl, Ito, Nobuaki, Javaid, Kassim, Kamenicky, Peter, Keen, Richard, Kubota, Takuo, Lachmann, Robin H., Perwad, Farzana, Pitukcheewanont, Pisit, Portale, Anthony, Ralston, Stuart H., Tanaka, Hiroyuki, Weber, Thomas J., Yoo, Han-Wook, Sun, Wei, Williams, Angela, Nixon, Annabel, and Takeuchi, Yasuhiro

Published
2022
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4. Burosumab treatment of X-linked hypophosphatemia patients: interim analysis of the SUNFLOWER longitudinal, observational cohort study

Author

Michigami, Toshimi, primary, Kang, Hee Gyung, additional, Namba, Noriyuki, additional, Ito, Nobuaki, additional, Kubota, Takuo, additional, Shintani, Ayumi, additional, Kabata, Daijiro, additional, Kanematsu, Masanori, additional, Nishida, Yayoi, additional, Fukumoto, Seiji, additional, and Ozono, Keiichi, additional

Published
2024
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6. Impact of X-linked hypophosphatemic rickets/osteomalacia on health and quality of life: baseline data from the SUNFLOWER longitudinal, observational cohort study.

Author

Namba, Noriyuki, Ito, Nobuaki, Michigami, Toshimi, Kang, Hee Gyung, Kubota, Takuo, Miyazaki, Osamu, Shintani, Ayumi, Kabata, Daijiro, Nishida, Yayoi, Fukumoto, Seiji, and Ozono, Keiichi

Subjects
BONE health, PHYSICAL mobility, BRIEF Pain Inventory, AGE groups, PHOSPHATE metabolism
Abstract

The SUNFLOWER study was initiated in Japan and South Korea to clarify the course of X-linked hypophosphatemic rickets/osteomalacia (XLH); delineate its physical, mental, and financial burdens; and collect information on treatment. Here, we report cross-sectional data at the time of patient enrollment to better understand the real-world management and complications in patients with XLH and examine the effect of XLH on quality of life (QOL). This is an ongoing, longitudinal, observational cohort study of patients with a diagnosis of XLH. Data from 147 patients (118 in Japan and 29 in South Korea) were evaluated. In total, 77 children (mean age, 9.7 yr; 67.5% female) and 70 adults (mean age, 37.6 yr; 65.7% female) were enrolled. PHEX gene mutations were confirmed in 46/77 (59.7%) children and 37/70 (52.9%) adults. Most patients in both age groups were receiving a combination of phosphate and active vitamin D at baseline. The mean height Z-score was −2.21 among adults (male: −2.34; female: −2.14). The mean Rickets Severity Score in children was 1.62. Whereas children appeared to have low pain levels (mean revised faces pain scale score, 1.3), adults reported mild-to-moderate pain (mean Brief Pain Inventory pain severity, 2.02). Mean QOL in children (assessed using the 10-item short-form health survey for children) was low, with a score below normative level for physical functioning. In adults, results from the Western Ontario and McMaster Universities osteoarthritis index indicated the presence of pain, stiffness, and decreased physical function. The respective mean total days/year of work/school non-attendance due to symptoms/complications and management of XLH were 0.7 and 3.0 among adults, and 6.4 and 6.1 among children. Our findings reconfirmed a relationship between disease and QOL in patients with XLH. We anticipate that these data will be important in enabling clinicians to understand the daily reality of patients with XLH. Lay Summary: X-linked hypophosphatemic rickets/osteomalacia (XLH) is a rare, PHEX gene mutation-linked disorder that causes weak bones and bone deformities. The ongoing SUNFLOWER study aims to collect information on Japanese and South Korean patients with XLH to better understand how this disease progresses over time, its impact on quality of life (QOL), and how it is currently being treated. Data from 147 patients (77 children and 70 adults) were evaluated. Over half of the adults and children included in this study had a confirmed PHEX gene mutation. Although most patients were receiving conventional therapy for XLH, laboratory tests revealed that they had underlying issues with bone health and that their growth rates were still being negatively affected. Bone-related complications were more common among adults than children. Children reported low levels of pain, whereas adults reported mild-to-moderate pain. Children with XLH scored low for physical functioning on QOL tests. Adults with XLH reported pain, stiffness, and decreased physical function on QOL tests. XLH had a larger impact on children's school attendance than adults' work attendance. Our findings will help improve understanding of the daily reality of XLH patients in Japan and South Korea. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Genotype–phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling

Author

Ishihara, Yasuki, Ohata, Yasuhisa, Takeyari, Shinji, Kitaoka, Taichi, Fujiwara, Makoto, Nakano, Yukako, Yamamoto, Kenichi, Yamada, Chieko, Yamamoto, Katsusuke, Michigami, Toshimi, Mabe, Hiroyo, Yamaguchi, Takeshi, Matsui, Katsuyuki, Tamada, Izumi, Namba, Noriyuki, Yamamoto, Akiko, Etoh, Junya, Kawaguchi, Azusa, Kosugi, Rieko, Ozono, Keiichi, and Kubota, Takuo

Published
2021
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8. Clinical outcomes and medical management of achondroplasia in Japanese children: A retrospective medical record review of clinical data

Author

Saitou, Hiroyuki, primary, Kitaoka, Taichi, additional, Kubota, Takuo, additional, Kanno, Junko, additional, Mochizuki, Hiroshi, additional, Michigami, Toshimi, additional, Hasegawa, Kosei, additional, Fujiwara, Ikuma, additional, Hamajima, Takashi, additional, Harada, Daisuke, additional, Seki, Yuko, additional, Nagasaki, Keisuke, additional, Dateki, Sumito, additional, Namba, Noriyuki, additional, Tokuoka, Hirofumi, additional, Pimenta, Jeanne M., additional, Cohen, Shelda, additional, and Ozono, Keiichi, additional

Published
2024
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11. Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome

Author

Araki, Yoshinori, Nagaoka, Yoshinobu, Okamoto, Takayuki, Sato, Yasuyuki, Hayashi, Asako, Takahashi, Toshiyuki, Aoyagi, Hayato, Ueno, Michihiko, Nakanishi, Masanori, Toita, Nariaki, Uetake, Kimiaki, Kobayashi, Norio, Fujita, Shoji, Tsuruga, Kazushi, Kumagai, Naonori, Kudo, Hiroki, Tanaka, Eriko, Omori, Tae, Okada, Mari, Hatai, Yoshiho, Udagawa, Tomohiro, Motoyoshi, Yaeko, Ishikura, Kenji, Kamei, Koichi, Ogura, Masao, Sato, Mai, Kano, Yuji, Hattori, Motoshi, Miura, Kenichiro, Harita, Yutaka, Kanda, Shoichiro, Sawanobori, Emi, Kobayashi, Anna, Kojika, Manabu, Ohwada, Yoko, Yan, Kunimasa, Hataya, Hiroshi, Hamada, Riku, Terano, Chikako, Harada, Ryoko, Hamasaki, Yuko, Hashimoto, Junya, Ito, Shuichi, Machida, Hiroyuki, Inaba, Aya, Matsuyama, Takeshi, Goto, Miwa, Shimizu, Masaki, Ohta, Kazuhide, Ikezumi, Yohei, Yamada, Takeshi, Suzuki, Toshiaki, Tamamura, Soichi, Mori, Yukiko, Hidaka, Yoshihiko, Matsuoka, Daisuke, Kinoshita, Tatsuya, Noda, Shunsuke, Kitahara, Masashi, Fujita, Naoya, Hibino, Satoshi, Iijima, Kazumoto, Nozu, Kandai, Kaito, Hiroshi, Minamikawa, Shogo, Yamamura, Tomohiko, Nagano, China, Horinouchi, Tomoko, Nakanishi, Keita, Fujimura, Junya, Sakakibara, Nana, Aoto, Yuya, Ishiko, Shinya, Tanaka, Ryojiro, Kanda, Kyoko, Inaguma, Yosuke, Hashimura, Yuya, Ishimori, Shingo, Kamiyoshi, Naohiro, Shibano, Takayuki, Takeshima, Yasuhiro, Fujimaru, Rika, Ueda, Hiroaki, Ashida, Akira, Matsumura, Hideki, Kubota, Takuo, Kitaoka, Taichi, Okuda, Yusuke, Sawai, Toshihiro, Sakai, Tomoyuki, Shima, Yuko, Hama, Taketsugu, Fujieda, Mikiya, Ishihara, Masayuki, Itoh, Shigeru, Iwaki, Takuma, Shimizu, Maki, Nagatani, Koji, Kagami, Shoji, Urushihara, Maki, Kaku, Yoshitsugu, Nishimura, Manao, Yoshino, Miwa, Hatae, Ken, Hinokiyama, Maiko, Kuroki, Rie, Ohtsuka, Yasufumi, Oka, Masafumi, Nishimura, Shinji, Sato, Tadashi, Tanaka, Seiji, Zaitsu, Ayuko, Nakazato, Hitoshi, Tamura, Hiroshi, Nakanishi, Koichi, Cho, Min Hyun, Ha, Tae-Sun, Cheong, Hae Il, Kang, Hee Gyung, Ha, Il-Soo, Kim, Ji Hyun, Park, Peong Gang, Cho, Myung Hyun, Han, Kyoung Hee, Yang, Eun Mi, Quiroga, Alejandro, Moudgil, Asha, Chavers, Blanche, Kwon, Charles, Bowers, Corinna, Gipson, Deb, Chand, Deepa, Weaver, Donald Jack, Abraham, Elizabeth, Janjua, Halima, Lin, Jen-Jar, Greenbaum, Larry, Kallash, Mahmoud, Rheault, Michelle, De Jeus Gonzalez, Nilka, Brophy, Patrick, Gbadegesin, Rasheed, Nagaraj, Shashi, Massengill, Susan, Srivastava, Tarak, Hunley, Tray, Cai, Yi, Omoloja, Abiodun, Silva, Cynthia, Adeyemo, Adebowale, Thalgahagoda, Shenal, Kari, Jameela A., El Desoky, Sherif, Abdelhadi, Mohammed, Akil, Rachida, Azib, Sonia, Basmaci, Romain, Benoist, Gregoire, Bensaid, Philippe, Blanc, Philippe, Boyer, Olivia, Bucher, Julie, Chace, Anne, Chalvon, Arnaud, Cheminee, Marion, Chendjou, Sandrine, Daoud, Patrick, Deschênes, Georges, Dossier, Claire, Elias, Ossam, Gagliadone, Chantal, Gajdos, Vincent, Galerne, Aurélien, Aigrain, Evelyne Jacqz, Sanchez, Lydie Joly, Khaled, Mohamed, Khelfaoui, Fatima, Laoudi, Yacine, Larakeb, Anis, Limani, Tarek, Mahdi, Fouad, Mandelcwaijg, Alexis, Muller, Stephanie, Nacer, Kacem, Nathanson, Sylvie, Pellegrino, Béatrice, Pharaon, Isabelle, Roudault, Véronica, Rouget, Sébastien, Saf, Marc, Simon, Tabassom, Tahiri, Cedric, Ulinski, Tim, Zenkhri, Férielle, Jia, Xiaoyuan, McNulty, Michelle T., Song, Kyuyong, Hitomi, Yuki, Lee, Dongwon, Aiba, Yoshihiro, Khor, Seik-Soon, Ueno, Kazuko, Kawai, Yosuke, Nagasaki, Masao, Noiri, Eisei, Baek, Jiwon, Abeyagunawardena, Asiri, Lane, Brandon, Chryst-Stangl, Megan, Esezobor, Christopher, Solarin, Adaobi, Vivarelli, Marina, Debiec, Hanna, Matsuo, Masafumi, Ronco, Pierre, Sampson, Matthew G., and Tokunaga, Katsushi

Published
2020
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13. Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway*

Author

Tahimic, Candice GT, Long, Roger K, Kubota, Takuo, Sun, Maggie Yige, Elalieh, Hashem, Fong, Chak, Menendez, Alicia T, Wang, Yongmei, Vilardaga, Jean-Pierre, and Bikle, Daniel D

Subjects
Biochemistry and Cell Biology, Biological Sciences, Bioengineering, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Aetiology, 2.1 Biological and endogenous factors, Cell Line, Humans, Insulin-Like Growth Factor I, Integrins, Mechanotransduction, Cellular, Osteoblasts, Receptor, IGF Type 1, Signal Transduction, Stress, Mechanical, insulin-like growth factor, integrin, mechanotransduction, osteoblast, shear stress, IGF1 receptor, IGF1 signaling, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences
Abstract

Mechanical loading of the skeleton, as achieved during daily movement and exercise, preserves bone mass and stimulates bone formation, whereas skeletal unloading from prolonged immobilization leads to bone loss. A functional interplay between the insulin-like growth factor 1 receptor (IGF1R), a major player in skeletal development, and integrins, mechanosensors, is thought to regulate the anabolic response of osteogenic cells to mechanical load. The mechanistic basis for this cross-talk is unclear. Here we report that integrin signaling regulates activation of IGF1R and downstream targets in response to both IGF1 and a mechanical stimulus. In addition, integrins potentiate responsiveness of IGF1R to IGF1 and mechanical forces. We demonstrate that integrin-associated kinases, Rous sarcoma oncogene (SRC) and focal adhesion kinase (FAK), display distinct actions on IGF1 signaling; FAK regulates IGF1R activation and its downstream effectors, AKT and ERK, whereas SRC controls signaling downstream of IGF1R. These findings linked to our observation that IGF1 assembles the formation of a heterocomplex between IGF1R and integrin β3 subunit indicate that the regulation of IGF1 signaling by integrins proceeds by direct receptor-receptor interaction as a possible means to translate biomechanical forces into osteoanabolic signals.

Published
2016

14. IGF‐I Signaling in Osterix‐Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development

Author

Wang, Yongmei, Menendez, Alicia, Fong, Chak, ElAlieh, Hashem Z, Kubota, Takuo, Long, Roger, and Bikle, Daniel D

Subjects
Biomedical and Clinical Sciences, Pediatric, Musculoskeletal, Animals, Bone Development, Bone Marrow Cells, Bone and Bones, Cartilage, Cell Differentiation, Cell Proliferation, Chondrocytes, Ephrin-B2, Female, Femur, Gene Deletion, Genotype, Green Fluorescent Proteins, Growth Plate, Immunohistochemistry, Insulin-Like Growth Factor I, Integrases, Matrix Metalloproteinases, Mice, Mice, Knockout, Osteoblasts, Phenotype, Promoter Regions, Genetic, Real-Time Polymerase Chain Reaction, Receptors, Somatomedin, Signal Transduction, Tibia, Vascular Endothelial Growth Factor A, IGF-I RECEPTOR, ENDOCHONDRAL BONE FORMATION, SECONDARY OSSIFICATION CENTER, PERICHONDRIUM, OSTERIX-EXPRESSING CELLS, Biological Sciences, Engineering, Medical and Health Sciences, Anatomy & Morphology, Biological sciences, Biomedical and clinical sciences
Abstract

To investigate the role of IGF-I signaling in osterix (OSX)-expressing cells in the skeleton, we generated IGF-I receptor (IGF-IR) knockout mice ((OSX)IGF-IRKO) (floxed-IGF-IR mice × OSX promoter-driven GFP-labeled cre-recombinase [(OSX)GFPcre]), and monitored postnatal bone development. At day 2 after birth (P2), (OSX)GFP-cre was highly expressed in the osteoblasts in the bone surface of the metaphysis and in the prehypertrophic chondrocytes (PHCs) and inner layer of perichondral cells (IPCs). From P7, (OSX)GFP-cre was highly expressed in PHCs, IPCs, cartilage canals (CCs), and osteoblasts (OBs) in the epiphyseal secondary ossification center (SOC), but was only slightly expressed in the OBs in the metaphysis. Compared with the control mice, the IPC proliferation was decreased in the (OSX)IGF-IRKOs. In these mice, fewer IPCs invaded into the cartilage, resulting in delayed formation of the CC and SOC. Immunohistochemistry indicated a reduction of vessel number and lower expression of VEGF and ephrin B2 in the IPCs and SOC of (OSX)IGF-IRKOs. Quantitative real-time PCR revealed that the mRNA levels of the matrix degradation markers, MMP-9, 13 and 14, were decreased in the (OSX)IGF-IRKOs compared with the controls. The (OSX)IGF-IRKO also showed irregular morphology of the growth plate and less trabecular bone in the tibia and femur from P7 to 7 weeks, accompanied by decreased chondrocyte proliferation, altered chondrocyte differentiation, and decreased osteoblast differentiation. Our data indicate that during postnatal bone development, IGF-I signaling in OSX-expressing IPCs promotes IPC proliferation and cartilage matrix degradation and increases ephrin B2 production to stimulate vascular endothelial growth factor (VEGF) expression and vascularization. These processes are required for normal CC formation in the establishment of the SOC. Moreover, IGF-I signaling in the OSX-expressing PHC is required for growth plate maturation and osteoblast differentiation in the development of the metaphysis.

Published
2015

17. Gender‐Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts

Author

Babey, Muriel, Wang, Yongmei, Kubota, Takuo, Fong, Chak, Menendez, Alicia, ElAlieh, Hashem Z, and Bikle, Daniel D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Osteoporosis, 2.1 Biological and endogenous factors, Aetiology, Animals, Bone Development, Cells, Cultured, Female, Male, Mice, Mice, Knockout, Osteoblasts, Parathyroid Hormone, Receptor, IGF Type 1, Sex Characteristics, IGF1 RECEPTOR, MATURE OSTEOBLAST, CONTINUOUS PTH, SEX DIFFERENCE, OSTEOCLAST, Biological Sciences, Engineering, Medical and Health Sciences, Anatomy & Morphology, Biological sciences, Biomedical and clinical sciences
Abstract

The primary goal of this study was to determine whether the IGF1R in mature osteoblasts and osteocytes was required for the catabolic actions of continuous parathyroid hormone (cPTH). Igf1r was deleted from male and female FVN/B mice by breeding with mice expressing cre recombinase under control of the osteocalcin promoter ((0CN) Igfr1(-/-) ). Littermates lacking the cre recombinase served as controls. PTH, 60 μg/kg/d, was administered continuously by Alzet minipumps for 4 weeks. Blood was obtained for indices of calcium metabolism. The femurs were examined by micro-computed tomography for structure, immunohistochemistry for IGF1R expression, histomorphometry for bone formation rates (BFR), mRNA levels by qPCR, and bone marrow stromal cell cultures (BMSC) for alkaline phosphatase activity (ALP(+) ), mineralization, and osteoblast-induced osteoclastogenesis. Whereas cPTH led to a reduction in trabecular bone volume/tissue volume (BV/TV) and cortical thickness in the control females, no change was found in the control males. Although trabecular BV/TV and cortical thickness were reduced in the (0CN) Igfr1(-/-) mice of both sexes, no further reduction after cPTH was found in the females, unlike the reduction in males. BFR was stimulated by cPTH in the controls but blocked by Igf1r deletion in the females. The (0CN) Igfr1(-/-) male mice showed a partial response. ALP(+) and mineralized colony formation were higher in BMSC from control males than from control females. These markers were increased by cPTH in both sexes, but BMSC from male (0CN) Igfr1(-/-) also were increased by cPTH, unlike those from female (0CN) Igfr1(-/-) . cPTH stimulated receptor activator of NF-κB ligand (RANKL) and decreased osteoprotegerin and alkaline phosphatase expression more in control female bone than in control male bone. Deletion of Igf1r blocked these effects of cPTH in the female but not in the male. However, PTH stimulation of osteoblast-driven osteoclastogenesis was blocked by deleting Igfr1 in both sexes. We conclude that cPTH is catabolic in female but not male mice. Moreover, IGF1 signaling plays a greater role in the skeletal actions of cPTH in the female mouse than in the male mouse, which may underlie the sex differences in the response to cPTH.

Published
2015

19. Persistent growth-promoting effects of vosoritide in children with achondroplasia are accompanied by improvements in physical and social aspects of health-related quality of life

Author

Savarirayan, Ravi, Irving, Melita, Wilcox, William R., Bacino, Carlos A., Hoover-Fong, Julie E., Harmatz, Paul, Polgreen, Lynda E., Mohnike, Klaus, Prada, Carlos E., Kubota, Takuo, Arundel, Paul, Leiva-Gea, Antonio, Rowell, Richard, Low, Andrea, Sabir, Ian, Huntsman-Labed, Alice, and Day, Jonathan

Published
2024
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20. Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading

Author

Kubota, Takuo, Elalieh, Hashem Z, Saless, Neema, Fong, Chak, Wang, Yongmei, Babey, Muriel, Cheng, Zhiqiang, and Bikle, Daniel D

Subjects
Engineering, Aerospace Engineering, Osteoporosis, 2.1 Biological and endogenous factors, Aetiology, Musculoskeletal, Insulin-like growth factor 1 receptor, Osteoblasts, Unloading, Reloading, Periosteal bone formation, osteoblasts, periosteal bone formation, reloading, unloading, Mechanical Engineering, Aerospace & Aeronautics, Aerospace engineering
Abstract

Skeletal loading and unloading has a pronounced impact on bone remodeling, a process also regulated by insulin-like growth factor 1 (IGF-1) signaling. Skeletal unloading leads to resistance to the anabolic effect of IGF-1, while reloading after unloading restores responsiveness to IGF-1. However, a direct study of the importance of IGF-1 signaling in the skeletal response to mechanical loading remains to be tested. In this study, we assessed the skeletal response of osteoblast-specific Igf-1 receptor deficient (Igf-1r-/- ) mice to unloading and reloading. The mice were hindlimb unloaded for 14 days and then reloaded for 16 days. Igf-1r-/- mice displayed smaller cortical bone and diminished periosteal and endosteal bone formation at baseline. Periosteal and endosteal bone formation decreased with unloading in Igf-1r+/+ mice. However, the recovery of periosteal bone formation with reloading was completely inhibited in Igf-1r-/- mice, although reloading-induced endosteal bone formation was not hampered. These changes in bone formation resulted in the abolishment of the expected increase in total cross-sectional area with reloading in Igf-1r-/- mice compared to the control mice. These results suggest that the Igf-1r in mature osteoblasts has a critical role in periosteal bone formation in the skeletal response to mechanical loading.

Published
2013

21. Continued Beneficial Effects of Burosumab in Adults with X-Linked Hypophosphatemia: Results from a 24-Week Treatment Continuation Period After a 24-Week Double-Blind Placebo-Controlled Period

Author

Portale, Anthony A., Carpenter, Thomas O., Brandi, Maria Luisa, Briot, Karine, Cheong, Hae II, Cohen-Solal, Martine, Crowley, Rachel, Jan De Beur, Suzanne, Eastell, Richard, Imanishi, Yasuo, Imel, Erik A., Ing, Steven, Ito, Nobuaki, Javaid, Muhammad, Kamenicky, Peter, Keen, Richard, Kubota, Takuo, Lachmann, Robin, Perwad, Farzana, Pitukcheewanont, Pisit, Ralston, Stuart H., Takeuchi, Yasuhiro, Tanaka, Hiroyuki, Weber, Thomas J., Yoo, Han-Wook, Zhang, Lin, Theodore-Oklota, Christina, Mealiffe, Matt, San Martin, Javier, and Insogna, Karl

Published
2019
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25. Association of trabecular bone score and bone mineral apparent density with the severity of bone fragility in children and adolescents with osteogenesis imperfecta: A cross-sectional study

Author

Ohata, Yasuhisa, primary, Kitaoka, Taichi, additional, Ishimi, Takeshi, additional, Yamada, Chieko, additional, Nakano, Yukako, additional, Yamamoto, Kenichi, additional, Takeyari, Shinji, additional, Nakayama, Hirofumi, additional, Fujiwara, Makoto, additional, Kubota, Takuo, additional, and Ozono, Keiichi, additional

Published
2023
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27. P141: Persistent growth-promoting effects of vosoritide in children with achondroplasia is accompanied by improvement in physical aspects of quality of life*

Author

Savarirayan, Ravi, Tofts, Louise, Irving, Melita, Wilcox, William, Bacino, Carlos, Hoover-Fong, Julie, Font, Rosendo Ullot, Harmatz, Paul, Rutsch, Frank, Carroll, Ricki, Polgreen, Lynda, Ginebreda, Ignacio, Mohnike, Klaus, Charrow, Joel, Prada, Carlos, Hoernschemeyer, Daniel, Ozono, Keiichi, Kubota, Takuo, Alanay, Yasemin, Arundel, Paul, Kotani, Yumiko, Yasui, Natsuo, White, Klane, Brandstetter, Shelley, Saal, Howard, Leiva-Gea, Antonio, Luna-González, Felipe, Mochizuki, Hiroshi, Tajima, Asako, Basel, Donald, Fisheleva, Elena, Rowell, Richard, Labed, Alice Huntsman, and Day, Jonathan

Published
2024
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28. P139: Persistent growth-promoting effects of vosoritide in children with achondroplasia for up to 4 years: Update from phase 3 extension study*

Author

Savarirayan, Ravi, Tofts, Louise, Irving, Melita, Wilcox, William, Bacino, Carlos, Hoover-Fong, Julie, Font, Rosendo Ullot, Harmatz, Paul, Rutsch, Frank, Carroll, Ricki, Polgreen, Lynda, Ginebreda, Ignacio, Mohnike, Klaus, Charrow, Joel, Prada, Carlos, Hoernschemeyer, Daniel, Ozono, Keiichi, Kubota, Takuo, Alanay, Yasemin, Arundel, Paul, Kotani, Yumiko, Yasui, Natsuo, White, Klane, Brandstetter, Shelley, Saal, Howard, Leiva-Gea, Antonio, Luna-González, Felipe, Mochizuki, Hiroshi, Tajima, Asako, Basel, Donald, Fisheleva, Elena, Low, Andrea, Lawrinson, Sue, and Day, Jonathan

Published
2024
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36. Pathogenic variants of the GNAS gene introduce an abnormal amino acid sequence in the β6 strand/α5 helix of Gsα, causing pseudohypoparathyroidism type 1A and pseudopseudohypoparathyroidism in two unrelated Japanese families

Author

Ohata, Yasuhisa, primary, Kakimoto, Haruna, additional, Seki, Yuko, additional, Ishihara, Yasuki, additional, Nakano, Yukako, additional, Yamamoto, Kenichi, additional, Takeyari, Shinji, additional, Fujiwara, Makoto, additional, Kitaoka, Taichi, additional, Takakuwa, Satoshi, additional, Kubota, Takuo, additional, and Ozono, Keiichi, additional

Published
2022
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47. Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension

Author

Briot, Karine, primary, Portale, Anthony A, additional, Brandi, Maria Luisa, additional, Carpenter, Thomas O, additional, Cheong, Hae Ii, additional, Cohen-Solal, Martine, additional, Crowley, Rachel K, additional, Eastell, Richard, additional, Imanishi, Yasuo, additional, Ing, Steven, additional, Insogna, Karl, additional, Ito, Nobuaki, additional, Jan de Beur, Suzanne, additional, Javaid, Muhammad K, additional, Kamenicky, Peter, additional, Keen, Richard, additional, Kubota, Takuo, additional, Lachmann, Robin H, additional, Perwad, Farzana, additional, Pitukcheewanont, Pisit, additional, Ralston, Stuart H, additional, Takeuchi, Yasuhiro, additional, Tanaka, Hiroyuki, additional, Weber, Thomas J, additional, Yoo, Han-Wook, additional, Nixon, Annabel, additional, Nixon, Mark, additional, Sun, Wei, additional, Williams, Angela, additional, and Imel, Erik A, additional

Published
2021
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50. An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice

Author

Kimura, Takeshi, primary, Bosakova, Michaela, additional, Nonaka, Yosuke, additional, Hruba, Eva, additional, Yasuda, Kie, additional, Futakawa, Satoshi, additional, Kubota, Takuo, additional, Fafilek, Bohumil, additional, Gregor, Tomas, additional, Abraham, Sara P., additional, Gomolkova, Regina, additional, Belaskova, Silvie, additional, Pesl, Martin, additional, Csukasi, Fabiana, additional, Duran, Ivan, additional, Fujiwara, Masatoshi, additional, Kavkova, Michaela, additional, Zikmund, Tomas, additional, Kaiser, Josef, additional, Buchtova, Marcela, additional, Krakow, Deborah, additional, Nakamura, Yoshikazu, additional, Ozono, Keiichi, additional, and Krejci, Pavel, additional

Published
2021
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