1. [Normalizing effect of interferon on the system of mixed-function oxidases in the liver of mice with Lewis lung carcinoma].
- Author
-
Kudriabets IuI, Vorontsova AL, Orlovskiĭ AA, Pel'kis FP, and Chekhun VF
- Subjects
- Animals, Enzyme Activation, Lung Neoplasms secondary, Male, Mice, Mice, Inbred C57BL, Neoplasm Transplantation, Neoplasms, Experimental pathology, Vinblastine antagonists & inhibitors, Vinblastine pharmacokinetics, Vinblastine pharmacology, Interferons pharmacology, Liver enzymology, Mixed Function Oxygenases metabolism, Neoplasms, Experimental enzymology, Tumor Cells, Cultured drug effects
- Abstract
The effect of interferon (IF) on the activity of multipurpose hepatic oxidases (MHO) in animals in the process of metastatic tumour development as well as interaction of IF and vinblastine (VBL) in the cell culture have been studied. IF activates MHO under conditions of their inhibition at the beginning of the tumour development and inhibits them to the normal level under activation in the postmetastatic period. Contrary to the data obtained in vivo IF does not decrease the toxicity of VBL for the tumour cells in vitro. The data obtained evidence for the modulating effect of IF on the MHO system under the tumour development.
- Published
- 1987