439 results on '"Kuehn R"'
Search Results
2. Cell reprogramming modelled as transitions in a hierarchy of cell cycles
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Hannam, R, Annibale, A, and Kuehn, R
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Quantitative Biology - Cell Behavior ,Condensed Matter - Disordered Systems and Neural Networks ,Quantitative Biology - Molecular Networks - Abstract
We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell lineages. Although reprogramming has been demonstrated experimentally, much of the underlying processes governing cell fate decisions remain unknown. This work aims to bridge this gap by modelling cell types as a set of hierarchically related dynamical attractors representing cell cycles. Stages of the cell cycle are characterised by the configuration of gene expression levels, and reprogramming corresponds to triggering transitions between such configurations. Two mechanisms were found for reprogramming in a two level hierarchy: cycle specific perturbations and a noise-induced switching. The former corresponds to a \emph{directed} perturbation that induces a transition into a cycle state of a different cell type in the potency hierarchy (mainly a stem cell) whilst the latter is a priori undirected and could be induced, e.g., by a (stochastic) change in the cellular environment. These reprogramming protocols were found to be effective in large regimes of the parameter space and make specific predictions concerning reprogramming dynamics which are broadly in line with experimental findings.
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- 2016
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3. Spectra of Modular and Small-World Matrices
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Kuehn, R. and van Mourik, J. M.
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Condensed Matter - Disordered Systems and Neural Networks ,Computer Science - Social and Information Networks ,Physics - Physics and Society - Abstract
We compute spectra of symmetric random matrices describing graphs with general modular structure and arbitrary inter- and intra-module degree distributions, subject only to the constraint of finite mean connectivities. We also evaluate spectra of a certain class of small-world matrices generated from random graphs by introducing short-cuts via additional random connectivity components. Both adjacency matrices and the associated graph Laplacians are investigated. For the Laplacians, we find Lifshitz type singular behaviour of the spectral density in a localised region of small $|\lambda|$ values. In the case of modular networks, we can identify contributions local densities of state from individual modules. For small-world networks, we find that the introduction of short cuts can lead to the creation of satellite bands outside the central band of extended states, exhibiting only localised states in the band-gaps. Results for the ensemble in the thermodynamic limit are in excellent agreement with those obtained via a cavity approach for large finite single instances, and with direct diagonalisation results., Comment: 18 pages, 5 figures
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- 2010
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4. Quantum Statistical Physics of Glasses at Low Temperatures
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van Baardewijk, J. and Kuehn, R.
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Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Statistical Mechanics - Abstract
We present a quantum statistical analysis of a microscopic mean-field model of structural glasses at low temperatures. The model can be thought of as arising from a random Born von Karman expansion of the full interaction potential. The problem is reduced to a single-site theory formulated in terms of an imaginary-time path integral using replicas to deal with the disorder. We study the physical properties of the system in thermodynamic equilibrium and develop both perturbative and non-perturbative methods to solve the model. The perturbation theory is formulated as a loop expansion in terms of two-particle irreducible diagrams, and is carried to three-loop order in the effective action. The non-perturbative description is investigated in two ways, (i) using a static approximation, and (ii) via Quantum Monte Carlo simulations. Results for the Matsubara correlations at two-loop order perturbation theory are in good agreement with those of the Quantum Monte Carlo simulations. Characteristic low-temperature anomalies of the specific heat are reproduced, both in the non-perturbative static approximation, and from a three-loop perturbative evaluation of the free energy. In the latter case the result so far relies on using Matsubara correlations at two-loop order in the three-loop expressions for the free energy, as self-consistent Matsubara correlations at three-loop order are still unavailable. We propose to justify this by the good agreement of two-loop Matsubara correlations with those obtained non-perturbatively via Quantum Monte Carlo simulations., Comment: 13 pages, 6 figures
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- 2009
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5. Spectra of Modular Random Graphs
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Ergun, G. and Kuehn, R.
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Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Statistical Mechanics - Abstract
We compute spectra of symmetric random matrices defined on graphs exhibiting a modular structure. Modules are initially introduced as fully connected sub-units of a graph. By contrast, inter-module connectivity is taken to be incomplete. Two different types of inter-module connectivity are considered, one where the number of intermodule connections per-node diverges, and one where this number remains finite in the infinite module-size limit. In the first case, results can be understood as a perturbation of a superposition of semicircular spectral densities one would obtain for uncoupled modules. In the second case, matters can be more involved, and depend in detail on inter-module connectivities. For suitable parameters we even find near-triangular shaped spectral densities, similar to those observed in certain scale-free networks, in a system of consisting of just two coupled modules. Analytic results are presented for the infinite module-size limit; they are well corroborated by numerical simulations., Comment: 16 pages, 4 figures. to appear in J. Phys. A
- Published
- 2009
6. Credit contagion and credit risk
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Hatchett, J. P. L. and Kuehn, R.
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Physics - Physics and Society ,Quantitative Finance - Risk Management - Abstract
We study a simple, solvable model that allows us to investigate effects of credit contagion on the default probability of individual firms, in both portfolios of firms and on an economy wide scale. While the effect of interactions may be small in typical (most probable) scenarios they are magnified, due to feedback, by situations of economic stress, which in turn leads to fatter tails in loss distributions of large loan portfolios., Comment: 11 pages, 3 figures
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- 2006
7. Effects of Economic Interactions on Credit Risk
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Hatchett, J. P. L. and Kuehn, R.
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Physics - Physics and Society ,Quantitative Finance - Risk Management - Abstract
We study a credit risk model which captures effects of economic interactions on a firm's default probability. Economic interactions are represented as a functionally defined graph, and the existence of both cooperative, and competitive, business relations is taken into account. We provide an analytic solution of the model in a limit where the number of business relations of each company is large, but the overall fraction of the economy with which a given company interacts may be small. While the effects of economic interactions are relatively weak in typical (most probable) scenarios, they are pronounced in situations of economic stress, and thus lead to a substantial fattening of the tails of loss distributions in large loan portfolios. This manifests itself in a pronounced enhancement of the Value at Risk computed for interacting economies in comparison with their non-interacting counterparts., Comment: 24 pages, 6 figures
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- 2005
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8. Influence of Random Internal Fields on the Tunneling of OH Defects in NaCl Crystals
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Thesen, M., Kühn, R., Enss, C., and Ludwig, S.
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Condensed Matter - Disordered Systems and Neural Networks - Abstract
Alkali halide crystals doped with certain impurity ions show a low temperature behaviour, which differs significantly from that of pure crystals. The origin of these characteristic differences are tunneling centers formed by atomic or molecular impurity ions. We have investigated the dielectric susceptibility of hydroxyl ions in NaCl crystals at very low concentrations (below 30 ppm), where interactions are believed to be negligible. We find that the temperature dependence of the susceptibility is noticeably different from what one would expect for isolated defects in a symmetric environment. We propose that the origin of these deviations are random internal strains arising from imperfections of the host crystal. We will present the experimental data and a theoretical model which allows a quantitative understanding on a microscopic basis., Comment: 3 pages 3 figures, REVTeX, submitted to the proceedings of the PHONONS 2001 conference
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- 2001
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9. Learning structured data from unspecific reinforcement
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Biehl, M., Kuehn, R., and Stamatescu, I. -O.
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Condensed Matter - Abstract
We show that a straightforward extension of a simple learning model based on the Hebb rule, the previously introduced Association-Reinforcement-Hebb-Rule, can cope with "delayed", unspecific reinforcement also in the case of structured data and lead to perfect generalization., Comment: 13 pages, 3 figures
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- 2000
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10. Non-equilibrium dynamics of simple spherical spin models
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Zippold, W., Kuehn, R., and Horner, H.
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Condensed Matter - Statistical Mechanics - Abstract
We investigate the non-equilibrium dynamics of spherical spin models with two-spin interactions. For the exactly solvable models of the d-dimensional spherical ferromagnet and the spherical Sherrington-Kirkpatrick model the asymptotic dynamics has for large times and for large waiting times the same formal structure. In the limit of large waiting times we find in both models an intermediate time scale, scaling as a power of the waiting time with an exponent smaller than one, and thus separating the time-translation invariant short-time dynamics from the aging regime. It is this time scale on which the fluctuation-dissipation regime is violated. Aging in these models is similar to that observed in spin glasses at the level of correlation functions, but different at the level of response functions, and thus different at the level of experimentally accessible quantities like the thermoremanent magnetization., Comment: 8 pages, 1 eps figure
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- 1999
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11. Critical Behaviour of the Randomly Spin--Diluted 2-d Ising Model --- A Grand Ensemble Approach
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Kühn, R.
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Condensed Matter ,High Energy Physics - Lattice - Abstract
The critical behaviour of the randomly spin-diluted Ising model in two space dimensions is investigated by a new method which combines a grand ensemble approach to disordered systems proposed by Morita with the phenomenological renormalization group scheme of Nightingale. Accurate approximations for the phase diagram and for the connectivity length exponent of the percolation transition are obtained. Our results suggest that the thermal phase transition of the disordered system might be different from that of the pure system: we observe a continuous variation of critical exponents with the density $\rho$ of magnetic impurities, respecting, however, weak universality in the sense that $\eta$ and $\gamma/\nu$ do {\it not\/} depend on $\rho$ while $\gamma$ and $\nu$ separately do. Our results are in qualitative and quantitative agreement with a recent Monte--Carlo study., Comment: 10 pages, LaTeX, 2 Figures available by Fax upon request from the author, TVP-94
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- 1994
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12. Replica Symmetry Breaking in Attractor Neural Network Models
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Steffan, H. and Kühn, R.
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Condensed Matter - Abstract
The phenomenon of replica symmetry breaking is investigated for the retrieval phases of Hopfield-type network models. The basic calculation is done for the generalized version of the standard model introduced by Horner [1] and by Perez-Vicente and Amit [2] which can exhibit low mean levels of neural activity. For a mean activity $\bar a =1/2$ the Hopfield model is recovered. In this case, surprisingly enough, we cannot confirm the well known one step replica symmetry breaking (1RSB) result for the storage capacity which was presented by Crisanti, Amit and Gutfreund [3] ($\alpha_c^{\hbox{\mf 1RSB}}\simeq 0.144$). Rather, we find that 1RSB- and 2RSB-Ans\"atze yield only slightly increased capacities as compared to the replica symmetric value ($\alpha_c^{\hbox{\mf 1RSB}}\simeq 0.138\,186$ and $\alpha_c^{\hbox{\mf 2RSB}}\simeq 0.138\,187 $ compared to $\alpha_c^{\hbox{\mf RS}}\simeq 0.137\,905$), significantly smaller also than the value $\alpha_c^{\hbox{\mf sim}} = 0.145\pm 0.009$ reported from simulation studies. These values still lie within the recently discovered reentrant phase [4]. We conjecture that in the infinite Parisi-scheme the reentrant behaviour disappears as is the case in the SK-spin-glass model (Parisi--Toulouse-hypothesis). The same qualitative results are obtained in the low activity range., Comment: Latex file, 20 pages, 8 Figures available from the authors upon request, HD-TVP-94-4
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- 1994
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13. The coupling between tropical meteorology, aerosol lifecycle, convection, and radiation, during the Cloud, Aerosol and Monsoon Processes Philippines Experiment (CAMP2Ex)
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Reid, J. S., primary, Maring, H. B., additional, Narisma, G. T., additional, van den Heever, S., additional, Di Girolamo, L., additional, Ferrare, R., additional, Lawson, P., additional, Mace, G. G., additional, Simpas, J. B., additional, Tanelli, S., additional, Ziemba, L., additional, van Diedenhoven, B., additional, Bruintjes, R., additional, Bucholtz, A., additional, Cairns, B., additional, Cambaliza, M. O., additional, Chen, G., additional, Diskin, G. S., additional, Flynn, J. H., additional, Hostetler, C. A., additional, Holz, R. E., additional, Lang, T. J., additional, Schmidt, K. S., additional, Smith, G., additional, Sorooshian, A., additional, Thompson, E. J., additional, Thornhill, K. L., additional, Trepte, C., additional, Wang, J., additional, Woods, S., additional, Yoon, S., additional, Alexandrov, M., additional, Alvarez, S., additional, Amiot, C. G., additional, Bennett, J. R., additional, Brooks, M.,, additional, Burton, S. P., additional, Cayanan, E., additional, Chen, H., additional, Collow, A., additional, Crosbie, E., additional, DaSilva, A., additional, DiGangi, J. P., additional, Flagg, D. D., additional, Freeman, S. W., additional, Fu, D., additional, Fukada, E., additional, Hilario, M. R. A., additional, Hong, Y., additional, Hristova-Veleva, S. M., additional, Kuehn, R., additional, Kowch, R. S., additional, Leung, G. R., additional, Loveridge, J., additional, Meyer, K., additional, Miller, R. M., additional, Montes, M. J., additional, Moum, J. N., additional, Nenes, Thanos, additional, Nesbitt, S. W., additional, Norgren, M., additional, Nowottnick, E. P., additional, Rauber, R. M., additional, Reid, E. A., additional, Rutledge, S., additional, Schlosser, J. S., additional, Sekiyama, T. T., additional, Shook, M. A., additional, Sokolowsky, G. A., additional, Stamnes, S. A., additional, Tanaka, T. Y., additional, Wasilewski, A., additional, Xian, P., additional, Xiao, Q., additional, Xu, Zhuocan, additional, and Zavaleta, J., additional
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- 2023
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14. Genome wide conditional mouse knockout resources
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Kaloff, C., Anastassiadis, K., Ayadi, A., Baldock, R., Beig, J., Birling, M.-C., Bradley, A., Brown, S.D.M., Bürger, A., Bushell, W., Chiani, F., Collins, F.S., Doe, B., Eppig, J.T., Finnell, R.H., Fletcher, C., Flicek, P., Fray, M., Friedel, R.H., Gambadoro, A., Gates, H., Hansen, J., Herault, Y., Hicks, G.G., Hörlein, A., Hrabé de Angelis, M., Iyer, V., de Jong, P.J., Koscielny, G., Kühn, R., Liu, P., Lloyd, K.C.K, Lopez, R.G., Marschall, S., Martínez, S., McKerlie, C., Meehan, T., von Melchner, H., Moore, M., Murray, S.A., Nagy, A., Nutter, L.M.J., Pavlovic, G., Pombero, A., Prosser, H., Ramirez-Solis, R., Ringwald, M., Rosen, B., Rosenthal, N., Rossant, J., Ruiz Noppinger, P., Ryder, E., Skarnes, W.C., Schick, J., Schnütgen, F., Schofield, P., Seisenberger, C., Selloum, M., Smedley, D., Simpson, E.M., Stewart, A.F., Teboul, L., Tocchini Valentini, G.P., Valenzuela, D., West, A.P., and Wurst, W.
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- 2016
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15. Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins
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Kuehn, R, Stoesser, N, Eyre, D, Darton, TC, Basnyat, B, and Parry, CM
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Adult ,Ofloxacin ,Adolescent ,Ceftriaxone ,Azithromycin ,Cephalosporins ,Anti-Bacterial Agents ,Chloramphenicol ,Anti-Infective Agents ,Cefixime ,Ciprofloxacin ,Recurrence ,Paratyphoid Fever ,Humans ,Pakistan ,Pharmacology (medical) ,Typhoid Fever ,Child ,Fluoroquinolones ,Monobactams - Abstract
Background Typhoid and paratyphoid (enteric fever) are febrile bacterial illnesses common in many low‐ and middle‐income countries. The World Health Organization (WHO) currently recommends treatment with azithromycin, ciprofloxacin, or ceftriaxone due to widespread resistance to older, first‐line antimicrobials. Resistance patterns vary in different locations and are changing over time. Fluoroquinolone resistance in South Asia often precludes the use of ciprofloxacin. Extensively drug‐resistant strains of enteric fever have emerged in Pakistan. In some areas of the world, susceptibility to old first‐line antimicrobials, such as chloramphenicol, has re‐appeared. A Cochrane Review of the use of fluoroquinolones and azithromycin in the treatment of enteric fever has previously been undertaken, but the use of cephalosporins has not been systematically investigated and the optimal choice of drug and duration of treatment are uncertain. Objectives To evaluate the effectiveness of cephalosporins for treating enteric fever in children and adults compared to other antimicrobials. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL, MEDLINE, Embase, LILACS, the WHO ICTRP and ClinicalTrials.gov up to 24 November 2021. We also searched reference lists of included trials, contacted researchers working in the field, and contacted relevant organizations. Selection criteria We included randomized controlled trials (RCTs) in adults and children with enteric fever that compared a cephalosporin to another antimicrobial, a different cephalosporin, or a different treatment duration of the intervention cephalosporin. Enteric fever was diagnosed on the basis of blood culture, bone marrow culture, or molecular tests. Data collection and analysis We used standard Cochrane methods. Our primary outcomes were clinical failure, microbiological failure and relapse. Our secondary outcomes were time to defervescence, duration of hospital admission, convalescent faecal carriage, and adverse effects. We used the GRADE approach to assess certainty of evidence for each outcome. Main results We included 27 RCTs with 2231 total participants published between 1986 and 2016 across Africa, Asia, Europe, the Middle East and the Caribbean, with comparisons between cephalosporins and other antimicrobials used for the treatment of enteric fever in children and adults. The main comparisons are between antimicrobials in most common clinical use, namely cephalosporins compared to a fluoroquinolone and cephalosporins compared to azithromycin. Cephalosporin (cefixime) versus fluoroquinolones Clinical failure, microbiological failure and relapse may be increased in patients treated with cefixime compared to fluoroquinolones in three small trials published over 14 years ago: clinical failure (risk ratio (RR) 13.39, 95% confidence interval (CI) 3.24 to 55.39; 2 trials, 240 participants; low‐certainty evidence); microbiological failure (RR 4.07, 95% CI 0.46 to 36.41; 2 trials, 240 participants; low‐certainty evidence); relapse (RR 4.45, 95% CI 1.11 to 17.84; 2 trials, 220 participants; low‐certainty evidence). Time to defervescence in participants treated with cefixime may be longer compared to participants treated with fluoroquinolones (mean difference (MD) 1.74 days, 95% CI 0.50 to 2.98, 3 trials, 425 participants; low‐certainty evidence). Cephalosporin (ceftriaxone) versus azithromycin Ceftriaxone may result in a decrease in clinical failure compared to azithromycin, and it is unclear whether ceftriaxone has an effect on microbiological failure compared to azithromycin in two small trials published over 18 years ago and in one more recent trial, all conducted in participants under 18 years of age: clinical failure (RR 0.42, 95% CI 0.11 to 1.57; 3 trials, 196 participants; low‐certainty evidence); microbiological failure (RR 1.95, 95% CI 0.36 to 10.64, 3 trials, 196 participants; very low‐certainty evidence). It is unclear whether ceftriaxone increases or decreases relapse compared to azithromycin (RR 10.05, 95% CI 1.93 to 52.38; 3 trials, 185 participants; very low‐certainty evidence). Time to defervescence in participants treated with ceftriaxone may be shorter compared to participants treated with azithromycin (mean difference of −0.52 days, 95% CI −0.91 to −0.12; 3 trials, 196 participants; low‐certainty evidence). Cephalosporin (ceftriaxone) versus fluoroquinolones It is unclear whether ceftriaxone has an effect on clinical failure, microbiological failure, relapse, and time to defervescence compared to fluoroquinolones in three trials published over 28 years ago and two more recent trials: clinical failure (RR 3.77, 95% CI 0.72 to 19.81; 4 trials, 359 participants; very low‐certainty evidence); microbiological failure (RR 1.65, 95% CI 0.40 to 6.83; 3 trials, 316 participants; very low‐certainty evidence); relapse (RR 0.95, 95% CI 0.31 to 2.92; 3 trials, 297 participants; very low‐certainty evidence) and time to defervescence (MD 2.73 days, 95% CI −0.37 to 5.84; 3 trials, 285 participants; very low‐certainty evidence). It is unclear whether ceftriaxone decreases convalescent faecal carriage compared to the fluoroquinolone gatifloxacin (RR 0.18, 95% CI 0.01 to 3.72; 1 trial, 73 participants; very low‐certainty evidence) and length of hospital stay may be longer in participants treated with ceftriaxone compared to participants treated with the fluoroquinolone ofloxacin (mean of 12 days (range 7 to 23 days) in the ceftriaxone group compared to a mean of 9 days (range 6 to 13 days) in the ofloxacin group; 1 trial, 47 participants; low‐certainty evidence). Authors' conclusions Based on very low‐ to low‐certainty evidence, ceftriaxone is an effective treatment for adults and children with enteric fever, with few adverse effects. Trials suggest that there may be no difference in the performance of ceftriaxone compared with azithromycin, fluoroquinolones, or chloramphenicol. Cefixime can also be used for treatment of enteric fever but may not perform as well as fluoroquinolones. We are unable to draw firm general conclusions on comparative contemporary effectiveness given that most trials were small and conducted over 20 years previously. Clinicians need to take into account current, local resistance patterns in addition to route of administration when choosing an antimicrobial.
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- 2022
16. The methylation inhibitor 3DZNep promotes HDR pathway choice during CRISPR-Cas9 genome editing
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Bischoff, N., Wimberger, S., Kuehn, R., Laugesen, A., Turan, V., Larsen, B.D., Sørensen, C.S., Helin, K., Bennett, E.P., Maresca, M., and Brakebusch, C.
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Cancer Research ,Fuel Technology ,Energy Engineering and Power Technology ,Technology Platforms - Abstract
Alteration of specific epigenetic marks might promote homology directed repair (HDR) during CRISPR-Cas9 genome editing. Testing several epigenetic inhibitors in a traffic light reporter assay, the histone methylation inhibitor 3DZNep showed a significant HDR promoting effect, while non-homologous end joining mediated repair was not significantly changed. This HDR promoting effect was largely independent of the target gene and its expression levels but showed a limited cell type specificity. HDR promotion was independent of the best described target of 3DZNep, the H3K27 methyltransferase EZH2, and of altered gene expression, but correlated partially with increased frequency of S/G2 cell cycle stage.
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- 2023
17. RNA Interference in Mice
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Kühn, R., Streif, S., Wurst, W., Starke, K., editor, Born, G. V. R., editor, Duckles, S., editor, Eichelbaum, M., editor, Ganten, D., editor, Hofmann, F., editor, Rosenthal, W., editor, Rubanyi, G., editor, Feil, Robert, editor, and Metzger, Daniel, editor
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- 2007
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18. Radiochemotherapy in Locally Invasive Non-Metastatic Carcinoma of the Bladder
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Brod, J. L., Kühn, R., Schafhauser, W., Schrott, K. M., Atala, Anthony, editor, and Slade, Debra, editor
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- 2003
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19. Benigne testikuläre Fehlbildungen und Erkrankungen des Kindesalters
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Rösch, W., Kühn, R., Sigel, A., editor, and Ringert, R.-H., editor
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- 2001
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20. Erkrankungen des Penis im Kindesalter
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Kühn, R., Sigel, A., editor, and Ringert, R.-H., editor
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- 2001
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21. Enhancement of CRISPR-Cas9 induced precise gene editing by targeting histone H2A-K15 ubiquitination
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Bashir, S., Dang, T., Rossius, J., Wolf, J., and Kuehn, R.
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Cancer Research ,DNA End-Joining Repair ,DNA Repair ,RNF169 ,Ubiquitin-Protein Ligases ,lcsh:Biotechnology ,Gene Expression ,Histones ,tetR ,lcsh:TP248.13-248.65 ,HR ,Animals ,Humans ,Clustered Regularly Interspaced Short Palindromic Repeats ,Gene Knock-In Techniques ,Gene Editing ,Lamin Type B ,BRCA1 Protein ,Ubiquitin ,Ubiquitination ,Recombinational DNA Repair ,Precise gene editing ,Rad18 ,BRCA1 ,DNA-Binding Proteins ,HEK293 Cells ,CRISPR ,Cas9. Genome editing ,Gal4 ,Technology Platforms ,CRISPR-Cas Systems ,Research Article - Abstract
Background Precise genetic modifications are preferred products of CRISPR-Cas9 mediated gene editing in mammalian cells but require the repair of induced double-strand breaks (DSB) through homology directed repair (HDR). Since HDR competes with the prevailing non-homologous end joining (NHEJ) pathway and depends on the presence of repair templates its efficiency is often limited and demands optimized methodology. Results For the enhancement of HDR we redirect the DSB repair pathway choice by targeting the Ubiquitin mark for damaged chromatin at Histone H2A-K15. We used fusions of the Ubiquitin binding domain (UBD) of Rad18 or RNF169 with BRCA1 to promote HDR initiation and UBD fusions with DNA binding domains to attract donor templates and facilitate HDR processing. Using a traffic light reporter system in human HEK293 cells we found that the coexpression of both types of UBD fusion proteins promotes HDR, reduces NHEJ and shifts the HDR/NHEJ balance up to 6-fold. The HDR enhancing effect of UBD fusion proteins was confirmed at multiple endogenous loci. Conclusions Our findings provide a novel efficient approach to promote precise gene editing in human cells. Supplementary information Supplementary information accompanies this paper at 10.1186/s12896-020-00650-x.
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- 2020
22. Muscle-Invasive Bladder Cancer: Transurethral Resection and Radiochemotherapy as an Organ-Sparing Treatment Option
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Sauer, R., Birkenhake, S., Kühn, R., Wittekind, C., Martus, P., Dunst, J., Schrott, K. M., Baert, A. L., editor, Heuck, F. H. W., editor, Youker, J. E., editor, Brady, L. W., editor, Heilmann, H.-P., editor, Petrovich, Zbigniew, editor, Baert, Luc, editor, and Brady, Luther W., editor
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- 1998
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23. Aufrechterhaltung der Mikrozirkulation durch den Bradykinin-Antagonisten Hoe 140 in der Na-Taurocholat-Pankreatitis der Ratte
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Kühn, R., Blöchle, C., Knoefel, W. T., Kusterer, K., Izbicki, J. R., Broelsch, C. E., Beger, Hans G., editor, Hierholzer, G., editor, Seifert, J., editor, and Hartel, W., editor
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- 1995
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24. Multifractal Properties of Discrete Stochastic Mappings
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Behn, U., van Hemmen, J. L., Kühn, R., Lange, A., Zagrebnov, V. A., Fannes, Mark, editor, Maes, Christian, editor, and Verbeure, André, editor
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- 1994
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25. FACS-Analyse immunozytärer Membranantigene in mesenterialen Lymphknoten langzeitüberlebender Ratten nach allogener Dünndarmtransplantation
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Schlemminger, R., Gieseler, R. K. H., Kühn, R., Xu, H., Peters, J. H., Köhler, H., and Beger, Hans G., editor
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- 1994
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26. Benigne testikuläre Fehlbildungen und Erkrankungen des Kindesalters
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Rösch, W., Sigel, A., Kühn, R., and Sigel, Alfred, editor
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- 1993
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27. Erkrankungen des Penis im Kindesalter
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Kühn, R. and Sigel, Alfred, editor
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- 1993
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28. Statistical mechanics for networks of analog neurons
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Kühn, R., Araki, H., editor, Ehlers, J., editor, Hepp, K., editor, Kippenhahn, R., editor, Ruelle, D., editor, Weidenmüller, H. A., editor, Wess, J., editor, Zittartz, J., editor, Beiglböck, W., editor, and Garrido, Luis, editor
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- 1990
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29. Encoding and Decoding of Patterns which are Correlated in Space and Time
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van Hemmen, J. L., Gerstner, W., Herz, A., Kühn, R., Sulzer, B., Vaas, M., Brauer, W., editor, and Dorffner, Georg, editor
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- 1990
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30. Generation and Analysis of Interleukin-4 Deficient Mice
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Kühn, R., Rajewsky, K., and Müller, W.
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- 1991
31. MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7
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Fehling, H. J., Swat, W., Laplace, C., Kühn, R., Rajewsky, K., Müller, U., and von Boehmer, H.
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- 1994
32. Deformation, CPO, and Elastic Anisotropy in Low‐Grade Metamorphic Serpentinites, Atlantis Massif Oceanic Core Complex
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Kuehn, R., Behrmann, Jan H., Stipp, Michael, Kilian, R., Leiss, B., Kuehn, R., Behrmann, Jan H., Stipp, Michael, Kilian, R., and Leiss, B.
- Abstract
Crystallographic preferred orientation (CPO) and the associated seismic anisotropy of serpentinites are important factors for the understanding of tectonic settings involving hydrated Earth´s mantle, for example, at slow-spreading mid-ocean ridges. CPO of lizardite and magnetite in low-grade metamorphic serpentinites from the Atlantis Massif oceanic core complex (Mid-Atlantic Ridge, 30°N) were determined using synchrotron high energy X-ray diffraction in combination with Rietveld texture analysis. Serpentinite mesh structures show weak CPO while deformed samples show a single (0001) maximum perpendicular to the foliation. Seismic anisotropies calculated from CPO show up to >11% anisotropy for compressional waves (Vp) and shear wave splitting up to 0.38 km/s in the deformed samples. This indicates that deformation in shear zones controls elastic anisotropy and highlights its importance in defining the seismic signature of hydrated upper mantle.
- Published
- 2021
- Full Text
- View/download PDF
33. Deformation, CPO, and Elastic Anisotropy in Low‐Grade Metamorphic Serpentinites, Atlantis Massif Oceanic Core Complex
- Author
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Kuehn, R., primary, Behrmann, J. H., additional, Stipp, M., additional, Kilian, R., additional, and Leiss, B., additional
- Published
- 2021
- Full Text
- View/download PDF
34. Fate of recombinant DNA and Cry1Ab protein after ingestion and dispersal of genetically modified maize in comparison to rapeseed by fallow deer (Dama dama)
- Author
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Guertler, P., Lutz, B., Kuehn, R., Meyer, H. H. D., Einspanier, R., Killermann, B., and Albrecht, C.
- Published
- 2008
- Full Text
- View/download PDF
35. Genetic diversity, gene flow and drift in Bavarian red deer populations (Cervus elaphus)
- Author
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Kuehn, R., Schroeder, W., Pirchner, F., and Rottmann, O.
- Published
- 2003
- Full Text
- View/download PDF
36. New Wisconsin butterfly records
- Author
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Kuehn, R M and BioStor
- Published
- 1984
37. Process Definition for Obtaining Ultra-Thin Silicon Oxides Using Full-Wafer Electrical and Optical Measurements
- Author
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Oberhofer, A., Chen, J., Koh, K., Schrader, M., Shah, S., Venables, R., Young, C., Xu, M., Kuehn, R., Maher, D., and Venables, D.
- Published
- 1999
- Full Text
- View/download PDF
38. A Comparison of Mos Devices with In-Situ Boron Doped Polysilicon and Poly Sige Gates Deposited in an Rtcvd System Using S12H6 and B2H6 Gas Mixture
- Author
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Mirabedini, M. R., Li, V. Z. Q., Acker, A. R., Kuehn, R. T., Venables, D., Öztürk, M. C., and Wortman, J. J.
- Published
- 1998
- Full Text
- View/download PDF
39. Legally true but misleading statements: a moral dilemma.
- Author
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Kuehn, R. John, III
- Subjects
Legal ethics -- Laws, regulations and rules ,Financial statements -- Laws, regulations and rules ,Fraud -- Laws, regulations and rules - Published
- 2000
40. Isolation and characterization of 11 novel microsatellite DNA markers in the noble crayfish, Astacus astacus
- Author
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Kõiv, K., Gross, R., Paaver, T., Hurt, M., and Kuehn, R.
- Published
- 2009
41. Genetic Roots of the Red Deer (Cervus elaphus) Population in Eastern Switzerland
- Author
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Kuehn, R., Haller, H., Schroeder, W., and Rottmann, O.
- Published
- 2004
42. Fate of recombinant DNA and Cry1Ab protein after ingestion and dispersal of genetically modified maize in comparison to rapeseed by fallow deer ( Dama dama )
- Author
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Guertler, P., Lutz, B., Kuehn, R., Meyer, H., Einspanier, R., Killermann, B., and Albrecht, C.
- Subjects
fungi ,food and beverages - Abstract
The fate of recombinant DNA in fallow deer (Dama dama) was investigated by feeding a diet of isogenic or genetically modified (GM) maize expressing Cry1Ab protein against the European corn borer (Ostrinia nubilalis). To study the degradability of ingested DNA, polymerase chain reaction (PCR) assays were introduced to detect fragments of the endogenous, highly abundant chloroplast-specific rubisco gene, the maize-specific zein gene and the recombinant cry1Ab gene. PCR analysis revealed that small chloroplast- and maize-specific DNA fragments were detectable in contents of rumen, abomasums, jejunum, caecum and colon and occasionally in visceral tissues. In contrast, no fragments of the recombinant cry1Ab gene were detectable in gastrointestinal (GI) contents. The Cry1Ab protein was analysed using an enzyme-linked immunosorbent assay (ELISA) and immunoblotting technique. Neither ELISA nor immunoblotting yielded positive signals of immunoactive Cry1Ab protein in GI contents and tissues of fallow deer fed with GM maize. In conclusion, after uptake of GM maize, neither cry1Ab-specific gene fragments nor Cry1Ab protein were detected in the GI tract of fallow deer, indicating complete digestion of the GM maize. Additional investigations on the germination capacity of conventional rapeseed and maize seed after ingestion by fallow deer and faecal excretion (endozoochory) were performed to draw conclusions regarding a potential spreading of germinable GM crop seed by deer. Germination tests revealed that germinable rapeseed kernels were detectable in faeces; in contrast, no intact maize seeds were found in faeces
- Published
- 2018
43. Influence of random internal fields on the tunneling of OH − defects in NaCl crystals
- Author
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Thesen, M., Kühn, R., Ludwig, S., and Enss, C.
- Published
- 2002
- Full Text
- View/download PDF
44. EPIDERMAL GROWTH FACTOR RECEPTOR AND G250: USEFUL TARGET ANTIGENS FOR ANTIBODY MEDIATED CELLULAR CYTOTOXICITY AGAINST RENAL CELL CARCINOMA?
- Author
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STADICK, H., STOCKMEYER, B., KÜHN, R., SCHROTT, K.M., KALDEN, J.R., GLENNIE, M.J., van de WINKEL, J.G.J., GRAMATZKI, M., VALERIUS, T., and ELS¨ASSER, D.
- Published
- 2002
- Full Text
- View/download PDF
45. A gravitational-wave standard siren measurement of the Hubble constant
- Author
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Abbott, and Abbott, B. P., and Abbott, R., and Acernese, T. D., and Ackley, F., and Adams, K., and Adams, C., and Addesso, T., and Adhikari, P., and Adya, R. X., and Affeldt, V. B., and Afrough, C., and Agarwal, M., and Agathos, B., and Agatsuma, M., and Aggarwal, K., and Aguiar, N., and Aiello, O. D., and Ain, L., and Ajith, A., and Allen, P., and Allen, B., and Allocca, G., and Altin, A., and Amato, P. A., and Ananyeva, A., and Anderson, A., and Anderson, S. B., and Angelova, W. G., and Antier, S. V., and Appert, S., and Arai, S., and Araya, K., and Areeda, M. C., and Arnaud, J. S., and Arun, N., and Ascenzi, K. G., and Ashton, S., and Ast, G., and Aston, M., and Astone, S. M., and Atallah, P., and Aufmuth, D. V., and Aulbert, P., and AultO'Neal, C., and Austin, K., and Avila-Alvarez, C., and Babak, A., and Bacon, S., and Bader, P., and Bae, M. K. M., and Baker, S., and Baldaccini, P. T., and Ballardin, F., and Ballmer, G., and Banagiri, S. W., and Barayoga, S., and Barclay, J. C., and Barish, S. E., and Barker, B. C., and Barkett, D., and Barone, K., and Barr, F., and Barsotti, B., and Barsuglia, L., and Barta, M., and Bartlett, D., and Bartos, J., and Bassiri, I., and Basti, R., and Batch, N., and Bawaj, J. C., and Bayley, M., and Bazzan, J. C., and Becsy, M., and Beer, B., and Bejger, C., and Belahcene, M., and Bell, I., and Berger, A. S., and Bergmann, B. K., and Bero, G., and Berry, J. J., and Bersanetti, C. P. L., and Bertolini, D., and Betzwieser, A., and Bhagwat, J., and Bhandare, S., and Bilenko, R., and Billingsley, I. A., and Billman, G., and Birch, C. R., and Birney, J., and Birnholtz, R., and Biscans, O., and Biscoveanu, S., and Bisht, S., and Bitossi, A., and Biwer, M., and Bizouard, C., and Blackburn, A., and Blackman, J. K., and Blair, J., and Blair, C. D., and Blair, D. G., and Bloemen, R. M., and Bock, S., and Bode, O., and Boer, N., and Bogaert, M., and Bohe, G., and Bondu, A., and Bonilla, F., and Bonnand, E., and Boom, R., and Bork, B. A., and Boschi, R., and Bose, V., and Bossie, S., and Bouffanais, K., and Bozzi, Y., and Bradaschia, A., and Brady, C., and Branchesi, P. R., and Brau, M., and Briant, J. E., and Brillet, T., and Brinkmann, A., and Brisson, M., and Brockill, V., and Broida, R., and Brooks, J. E., and Brown, N. F., and Brown, D. A., and Brunett, D. D., and Buchanan, S., and Buikema, C. C., and Bulik, A., and Bulten, H., and Buonanno, H. J., and Buskulic, A., and Buy, D., and Byer, C., and Cabero, R. L., and Cadonati, M., and Cagnoli, L., and Cahillane, G., and Bustillo, C., Calderon and Callister, J., and Calloni, T. A., and Camp, E., and Canepa, J. B., and Canizares, M., and Cannon, P., and Cao, K. C., and Cao, H., and Capano, J., and Capocasa, C. D., and Carbognani, E., and Caride, F., and Carney, S., and Diaz, M. F., Casanueva and Casentini, J., and Caudill, C., and Cavaglia, S., and Cavalier, M., and Cavalieri, F., and Cella, R., and Cepeda, G., and Cerda-Duran, C. B., and Cerretani, P., and Cesarini, G., and Chamberlin, E., and Chan, S. J., and Chao, M., and Charlton, S., and Chase, P., and Chassande-Mottin, E., and Chatterjee, E., and Chatziioannou, D., and Cheeseboro, K., and Chen, B. D., and Chen, H. Y., and Chen, X., and Cheng, Y., and Chia, H. -. P., and Chincarini, H., and Chiummo, N., and Chmiel, A., and Cho, T., and Cho, H. S., and Chow, M., and Christensen, J. H., and Chu, N., and Chua, Q., and Chua, A. J. K., and Chung, S., and Chung, A. K. W., and Ciani, S., and Ciolfi, G., and Cirelli, R., and Cirone, C. E., and Clara, N., and Clark, F., and Clearwater, J. A., and Cleva, P., and Cocchieri, F., and Coccia, C., and Cohadon, E., and Cohen, P. -. F., and Colla, D., and Collette, A., and Cominsky, C. G., and Constancio, L. R., J. r., and Conti, M., and Cooper, L., and Corban, S. J., and Corbitt, P., and Cordero-Carrion, T. R., and Corley, I., and Cornish, K. R., and Corsi, N., and Cortese, A., and Costa, S., and Coughlin, C. A., and Coughlin, M. W., and Coulon, S. B., and Countryman, J. -. P., and Couvares, S. T., and Covas, P., and Cowan, P. B., and Coward, E. E., and Cowart, D. M., and Coyne, M. J., and Coyne, D. C., and Creighton, R., and Creighton, J. D. E., and Cripe, T. D., and Crowder, J., and Cullen, S. G., and Cumming, T. J., and Cunningham, A., and Cuoco, L., and Dal Canton, E., and Dalya, T., and Danilishin, G., and D'Antonio, S. L., and Danzmann, S., and Dasgupta, K., and Costa, A., Da Silva and Datrier, C. F., and Dattilo, L. E. H., and Dave, V., and Davier, I., and Davis, M., and Daw, E. J., and Day, E. J., and De, B., and DeBra, S., and Degallaix, D., and De laurentis, J., and Deleglise, M., and Del Pozzo, S., and Demos, W., and Denker, N., and Dent, T., and De Pietri, T., and Dergachev, R., and De Rosa, V., and DeRosa, R., and De Rossi, R. T., and DeSalvo, C., and de Verona, R., and Devenson, O., and Dhurancihar, J., and Diaz, S., and Di Fiore, M. C., and Di Giovanni, L., and Di Girolamo, M., and Di Lieto, T., and Di Pace, A., and Di Palma, S., and Di Renzo, I., and Doctor, F., and Dolique, Z., and Donovan, V., and Dooley, F., and Doravari, K. L., and Dorrington, S., and Douglas, I., and Alvarez, R., Dovale and Downes, M., and Drago, T. P., and Dreissigacker, M., and Driggers, C., and Du, J. C., and Ducrot, Z., and Dupej, M., and Dwyer, P., and Edo, S. E., and Edwards, T. B., and Effler, M. C., and Eggenstein, N., and Ehrens, H. -. B., and Eichholz, P., and Eikenberry, J., and Eisenstein, S. S., and Essick, R. A., and Estevez, R. C., and Etienne, D., and Etzel, Z. B., and Evans, T., and Evans, M., and Factourovich, T. M., and Fafone, M., and Fair, V., and Fairhurst, H., and Fan, S., and Farinon, X., and Farr, S., and Farr, B., and Fauchon-Jones, W. M., and Favata, E. J., and Fays, M., and Fee, M., and Fehrmann, C., and Feicht, H., and Fejer, J., and Fernandez-Galiana, M. M., and Ferrante, A., and Ferreira, I., and Ferrini, E. C., and Fidecaro, F., and Finstad, F., and Fiori, D., and Fiorucci, I., and Fishbach, D., and Fisher, M., and Fitz-Axen, R. P., and Flaminio, M., and Fletcher, R., and Fong, M., and Font, H., and Forsyth, J. A., and Forsyth, P. W. F., and Fournier, S. S., and Frasca, J. -. D., and Frasconi, S., and Frei, E., and Freise, Z., and Frey, A., and Frey, R., and Fries, V., and Fritschel, E. M., and Frolov, P., and Fulda, V. V., and Fyffe, P., and Gabbard, M., and Gadre, H., and Gaebel, B. U., and Gair, S. M., and Gammaitoni, J. R., and Ganija, L., and Gaonkar, M. R., and Garcia-Quiros, S. G., and Garufi, C., and Gateley, F., and Gaudio, B., and Gaur, S., and Gayathril, G., and Gehrels, V., and Gemme, N., and Genin, G., and Gennai, E., and George, A., and George, D., and Gergely, J., and Germain, L., and Ghonge, V., and Ghosh, S., Abhirup and Ghosh, Archisman and Ghosh, and Giaime, S., and Giardina, J. A., and Giazotto, K. D., and Gill, A., and Glover, K., and Goetz, L., and Goetz, E., and Gomes, R., and Goncharov, S., and Gonzalez, B., and Castro, G., Gonzalez and Gopakumar, J. M., and Gorodetsky, A., and Gossan, M. L., and Gosselin, S. E., and Gouaty, M., and Grado, R., and Graef, A., and Granata, C., and Grant, M., and Gras, A., and Gray, S., and Greco, C., and Green, G., and Gretarsson, A. C., and Groot, E. M., and Grote, P., and Grunewald, H., and Gruning, S., and Guidi, P., and Guo, G. M., and Gupta, X., and Gupta, A., and Gushwa, M. K., and Gustafson, K. E., and Gustafson, E. K., and Halim, R., and Hall, O., and Hall, B. R., and Hamilton, E. D., and Hammond, E. Z., and Haney, G., and Hanke, M., and Hanks, M. M., and Hanna, J., and Hannam, C., and Hannuksela, M. D., and Hanson, O. A., and Hardwick, J., and Harms, I., and Harry, J., and Harry, G. M., and Hart, I. W., and Hester, M. J., and Haughian, C. -. J., and Healy, K., and Heidmann, J., and Heintze, N., and Heitmann, M. C., and Hello, H., and Hemming, P., and Hendry, G., and Heng, M., and Hennig, I. S., and Heptonstall, J., and Heurs, A. W., and Hild, M., and Hinderer, S., and Hoak, T., and Hofman, D., and Holt, D., and Holz, K., and Hopkins, D. E., and Horst, P., and Hough, C., and Houston, J., and Howell, E. A., and Hreibi, E. J., and Hu, A., and Huerta, Y. M., and Huet, E. A., and Hughey, D., and Husa, B., and Huttner, S., and Huynh-Dinh, S. H., and Indik, T., and Inta, N., and Intini, R., and Isa, G., and Isac, H. N., and Isi, J. -. M., and Iyer, M., and Izumi, B. R., and Jacqmin, K., and Jani, T., and Jaranowski, K., and Jawahar, P., and Jimenez-Forteza, S., and Johnson, F., and Jones, W. W., and Jones, D. I., and Jonker, R., and Ju, R. J. G., and Junker, L., and Kalaghatgi, J., and Kalogera, C. V., and Kamai, V., and Kandhasamy, B., and Kang, S., and Kanner, G., and Kapadia, J. B., and Karki, S. J., and Karvinen, S., and Kasprzack, K. S., and Katolik, M., and Katsavounidis, M., and Katzman, E., and Kaufer, W., and Kawabe, S., and Kefelian, K., and Keitel, E., and Kemball, D., and Kennedy, A. J., and Kent, R., and Key, C., and Khalili, J. S., and Khan, F. Y., and Khan, I., and Khan, S., and Khazanov, Z., and Kijbunchoo, E. A., and Kim, N., Chunglee and Kim, and Kim, J. C., and Kim, K., and Kim, W., and Kim, W. S., and Kimbrell, Y. -. M., and King, S. J., and King, E. J., and Kinley-Hanlon, P. J., and Kirchhoff, M., and Kissel, R., and Kleybolte, J. S., and Klimenko, L., and Knowles, S., and Koch, T. D., and Koehlenbeck, P., and Koley, S. M., and Kondrashov, S., and Kontos, V., and Korobko, A., and Korth, M., and Kowalska, W. Z., and Kozak, I., and Kraemer, D. B., and Kringel, C., and Krishnan, V., and Krolak, B., and Kuehn, A., and Kumar, G., and Kumar, P., and Kumar, R., and Kuo, S., and Kutynia, L., and Kwang, A., and Lackey, S., and Lai, B. D., and Landry, K. H., and Lang, M., and Lange, R. N., and Lantz, J., and Lanza, B., and Lartaux-Vollard, R. K., and Lasky, N., and Laxen, P. D., and Lazzarini, M., and Lazzaro, A., and Leaci, C., and Leavey, P., and Lee, S., and Lee, C. H., and Lee, H. K., and Lee, H. M., and Lee, H. W., and Lehmann, K., and Lenon, J., and Leonardi, A., and Leroy, M., and Letendre, N., and Levin, N., and Li, Y., and Linker, T. G. F., and Littenberg, S. D., and Liu, T. B., and Liu, J., and Lo, X., and Lockerbie, R. K. L., and London, N. N., and Lord, L. T., and Lorenzini, J. E., and Loriette, M., and Lormand, V., and Losurdo, M., and Lough, G., and Lousto, J. D., and Lovelace, C. O., and Lueock, G., and Lumaca, H., and Lundgren, D., and Lynch, A. P., and Ma, R., and Macas, Y., and Macfoy, R., and Machenschalk, S., and Maclnnis, B., and Macleod, M., and Hernandez, D. M., Magana and Magana-Sandoval, I., and Zertuche, F., Magana and Magee, L., and Majorana, R. M., and Maksimovic, E., and Man, I., and Mandic, N., and Mangano, V., and Mansell, V., and Manske, G. L., and Mantovani, M., Marchesoni, F., And, Marion, and Marka, F., and Marka, S., and Markakis, Z., and Markosyan, C., and Markowitz, A. S., and Maros, A., and Marquina, E., and Martelli, A., and Martellini, F., and Martin, L., and Martin, I. W., and Martynov, R. M., and Mason, D. V., and Massera, K., and Masserot, E., and Massinger, A., and Masso-Reid, T. J., and Mastrogiovanni, M., and Matas, S., and Matichard, A., and Matone, F., and Mavalvala, L., and Mazumder, N., and McCarthy, N., and McClelland, R., and McCormick, D. E., and McCuller, S., and McGuire, L., and McIntyre, S. C., and McIver, G., and McManus, J., and McNeill, D. J., and McRae, L., and McWilliams, T., and Meacher, S. T., and Meadors, D., and Mehmet, G. D., and Meidam, M., and Mejuto-Villa, J., and Melatos, E., and Mendell, A., and Mercer, G., and Merilh, R. A., and Merzougui, E. L., and Meshkov, M., and Messenger, S., and Messick, C., and Metzdorff, C., and Meyers, R., and Miao, P. M., and Michel, H., and Middleton, C., and Mikhailov, H., and Milano, E. E., and Miller, L., and Miller, A. L., and Miller, B. B., and Millhouse, J., and Milovich-Goff, M., and Minazzoli, M. C., and Minenkov, O., and Ming, Y., and Mishra, J., and Mitra, C., and Mitrofanov, S., and Mitselmakher, V. R., and Mittleman, G., and Moffa, R., and Moggi, D., and Mogushi, N., and Mohan, K., and Mohapatra, M., and Montani, S. R. P., and Moore, M., and Moraru, C. J., and Moreno, D., and Morriss, G., and Mours, S. R., and Mow-Lowry, B., and Mueller, C. M., and Muir, G., and Mukherjee, A. W., Arunava and Mukherjee, and Mukherjee, D., and Mukund, S., and Mullavey, N., and Munch, A., and Muniz, J., and Muratore, E. A., and Murray, M., and Napier, P. G., and Nardecchia, K., and Naticchioni, I., and Nayak, L., and Neilson, R. K., and Nelemans, J., and Nelson, G., and Nery, T. J. N., and Neunzert, M., and Nevin, A., and Newport, L., and Newton, J. M., and Ng, G., and Nguyen, K. K. Y., and Nichols, T. T., and Nielsen, D., and Nissanke, A. B., and Nitz, S., and Noack, A., and Nocera, A., and Nolting, F., and North, D., and Nuttall, C., and Oberling, L. K., and O'Dea, J., and Ogin, G. D., and Oh, G. H., and Oh, J. J., and Ohme, S. H., and Okada, F., and Oliver, M. A., and Oppermann, M., and Oram, P., and O'Reilly, Richard J., and Ormiston, B., and Ortega, R., and O'Shaughnessy, L. F., and Ossokine, R., and Ottaway, S., and Overmier, D. J., and Owen, H., and Pace, B. J., and Page, A. E., and Page, J., and Pai, M. A., and Pai, A., and Palamos, S. A., and Palashov, J. R., and Palomba, O., and Pal-Singh, C., and Pan, A., Howard and Pan, Huang-Wei and Pang, and Pang, B., and Pankow, P. T. H., and Pannarale, C., and Pant, F., and Paoletti, B. C., and Paoli, F., and Papa, A., and Parida, M. A., and Parker, A., and Pascucci, W., and Pasqualetti, D., and Passaquieti, A., and Passuello, R., and Patil, D., and Patricelli, M., and Pearlstone, B., and Pedraza, B. L., and Pedurand, M., and Pekowsky, R., and Pele, L., and Penn, A., and Perez, S., and Perreca, C. J., and Perri, A., and Pfeiffer, L. M., and Phelps, H. P., and Piccinni, M., and Pichot, O. J., and Piergiovanni, M., and Pierro, F., and Pillant, V., and Pinard, G., and Pinto, L., and Pirello, I. M., and Pitkin, M., and Poe, M., and Poggiani, M., and Popolizio, R., and Porter, P., and Post, E. K., and Powell, A., and Prasad, J., and Pratt, J., and Pratten, J. W. W., and Predoi, G., and Prestegard, V., and Prijatelj, T., and Principe, M., and Privitera, M., and Prodi, S., and Prokhorov, G. A., and Puncken, L. G., and Punturo, O., and Puppo, M., and Puerrer, P., and Qi, M., and Quetschke, H., and Quintero, V., and Quitzow-James, E. A., and Raab, R., and Rabeling, F. J., and Radkins, D. S., and Raffai, H., and Raja, P., and Rajan, S., and Rajbhandari, C., and Rakhmanov, B., and Ramirez, M., and Ramos-Buades, K. E., and Rapagnani, A., and Raymond, P., and Razzano, V., and Read, M., and Regimbau, J., and Rei, T., and Reid, L., and Reitze, S., and Ren, D. H., and Reyes, W., and Ricci, S. D., and Ricker, F., and Rieger, P. M., and Riles, S., and Rizzo, K., and Robertson, M., and Robie, N. A., and Robinet, R., and Rocchi, F., and Rolland, A., and Rollins, L., and Roma, J. G., and Romano, V. J., and Romano, J. D., and Romel, R., and Romie, C. L., and Rosinska, J. H., and Ross, D., and Rowan, M. P., and Ruediger, S., and Ruggi, A., and Rutins, P., and Ryan, G., and Sachdev, K., and Sadecki, S., and Sadeghian, I., and Sakellariadou, L., and Salconi, M., and Saleem, L., and Salemi, M., and Samajdar, F., and Sammut, A., and Sampson, L., and Sanchez, L. M., and Sanchez, E. J., and Sanchis-Gual, L. E., and Sandberg, N., and Sanders, V., and Sassolas, J. 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P., Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Adya, V. B., Affeldt, C., Afrough, M., Agarwal, B., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, B., Allen, G., Allocca, A., Altin, P. A., Amato, A., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arnaud, N., Arun, K. G., Ascenzi, S., Ashton, G., Ast, M., Aston, S. M., Astone, P., Atallah, D. V., Aufmuth, P., Aulbert, C., Aultoneal, K., Austin, C., Avila-Alvarez, A., Babak, S., Bacon, P., Bader, M. K. M., Bae, S., Baker, P. T., Baldaccini, F., Ballardin, G., Ballmer, S. W., Banagiri, S., Barayoga, J. C., Barclay, S. E., Barish, B. C., Barker, D., Barkett, K., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J. C., Bawaj, M., Bayley, J. 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L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Calderón Bustillo, J., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Canizares, P., Cannon, K. C., Cao, H., Cao, J., Capano, C. D., Capocasa, E., Carbognani, F., Caride, S., Carney, M. F., Casanueva Diaz, J., Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C. B., Cerdá-Durán, P., Cerretani, G., Cesarini, E., Chamberlin, S. J., Chan, M., Chao, S., Charlton, P., Chase, E., Chassande-Mottin, E., Chatterjee, D., Chatziioannou, K., Cheeseboro, B. D., Chen, H. Y., Chen, X., Chen, Y., Cheng, H. -P., Chia, H., Chincarini, A., Chiummo, A., Chmiel, T., Cho, H. S., Cho, M., Chow, J. H., Christensen, N., Chu, Q., Chua, A. J. K., Chua, S., Chung, A. K. W., Chung, S., Ciani, G., Ciolfi, R., Cirelli, C. E., Cirone, A., Clara, F., Clark, J. A., Clearwater, P., Cleva, F., Cocchieri, C., Coccia, E., Cohadon, P. -F., Cohen, D., Colla, A., Collette, C. G., Cominsky, L. R., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corley, K. R., Cornish, N., Corsi, A., Cortese, S., Costa, C. A., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Couvares, P., Covas, P. B., Cowan, E. E., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Cripe, J., Crowder, S. G., Cullen, T. J., Cumming, A., Cunningham, L., Cuoco, E., Dal Canton, T., Dálya, G., Danilishin, S. L., D'Antonio, S., Danzmann, K., Dasgupta, A., Da Silva Costa, C. F., Datrier, L. E. H., Dattilo, V., Dave, I., Davier, M., Davis, D., Daw, E. J., Day, B., De, S., Debra, D., Degallaix, J., De Laurentis, M., Deléglise, S., Del Pozzo, W., Demos, N., Denker, T., Dent, T., De Pietri, R., Dergachev, V., De Rosa, Rosario., Derosa, R. T., De Rossi, C., Desalvo, R., De Varona, O., Devenson, J., Dhurandhar, S., Díaz, M. C., Di Fiore, L., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Di Pace, S., Di Palma, I., Di Renzo, F., Doctor, Z., Dolique, V., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Douglas, R., Dovale Álvarez, M., Downes, T. P., Drago, M., Dreissigacker, C., Driggers, J. C., Du, Z., Ducrot, M., Dupej, P., Dwyer, S. E., Edo, T. B., Edwards, M. C., Effler, A., Eggenstein, H. -B., Ehrens, P., Eichholz, J., Eikenberry, S. S., Eisenstein, R. A., Essick, R. C., Estevez, D., Etienne, Z. B., Etzel, T., Evans, M., Evans, T. M., Factourovich, M., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fee, C., Fehrmann, H., Feicht, J., Fejer, M. M., Fernandez-Galiana, A., Ferrante, I., Ferreira, E. C., Ferrini, F., Fidecaro, F., Finstad, D., Fiori, I., Fiorucci, D., Fishbach, M., Fisher, R. P., Fitz-Axen, M., Flaminio, R., Fletcher, M., Fong, H., Font, J. A., Forsyth, P. W. F., Forsyth, S. S., Fournier, J. -D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fries, E. M., Fritschel, P., Frolov, V. V., Fulda, P., Fyffe, M., Gabbard, H., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gammaitoni, L., Ganija, M. R., Gaonkar, S. G., Garcia-Quiros, C., Garufi, F., Gateley, B., Gaudio, S., Gaur, G., Gayathri, V., Gehrels, N., Gemme, G., Genin, E., Gennai, A., George, D., George, J., Gergely, L., Germain, V., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giaime, J. A., Giardina, K. D., Giazotto, A., Gill, K., Glover, L., Goetz, E., Goetz, R., Gomes, S., Goncharov, B., González, G., Gonzalez Castro, J. M., Gopakumar, A., Gorodetsky, M. L., Gossan, S. E., Gosselin, M., Gouaty, R., Grado, A., Graef, C., Granata, M., Grant, A., Gras, S., Gray, C., Greco, G., Green, A. C., Gretarsson, E. M., Groot, P., Grote, H., Grunewald, S., Gruning, P., Guidi, G. M., Guo, X., Gupta, A., Gupta, M. K., Gushwa, K. E., Gustafson, E. K., Gustafson, R., Halim, O., Hall, B. 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Rennes ( INSA Rennes ) -École Nationale Supérieure des Sciences Appliquées et de Technologie ( ENSSAT ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Bretagne Loire ( UBL ) -IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ), Laboratoire Kastler Brossel ( LKB (Lhomond) ), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris ( FRDPENS ), Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ) -École normale supérieure - Paris ( ENS Paris ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Institut d'Astrophysique de Paris ( IAP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), ITA, USA, GBR, FRA, DEU, ESP, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), The LIGO Scientific Collaboration, The Virgo Collaboration, The 1M2H Collaboration, The Dark Energy Camera GW-EM Collaboration, The DES Collaboration, The DLT40 Collaboration, The Las Cumbres Observatory Collaboration, The VINROUGE Collaboration, The MASTER Collaboration, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), and (Astro)-Particles Physics
- Subjects
Gamma-Ray Bursts ,cosmological model ,neutron star: binary ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,[ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph] ,Astrophysics::High Energy Astrophysical Phenomena ,Density ,Field ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,gamma ray: burst ,gravitational radiation: direct detection ,General Relativity and Quantum Cosmology ,LIGO ,QC ,Astrophysics::Galaxy Astrophysics ,QB ,Gravitational Waves ,Gravitational Waves, Hubble Constant, LIGO, Virgo ,Multidisciplinary ,Hubble constant ,Virgo ,Hubble Constant ,Astrophysics::Instrumentation and Methods for Astrophysics ,Galaxies ,wave: electromagnetic ,Telescope Key Project ,VIRGO ,gravitational radiation: emission ,astro-ph.CO ,galaxy ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The detection of GW170817 in both gravitational waves and electromagnetic waves heralds the age of gravitational-wave multi-messenger astronomy. On 17 August 2017 the Advanced LIGO and Virgo detectors observed GW170817, a strong signal from the merger of a binary neutron-star system. Less than 2 seconds after the merger, a gamma-ray burst (GRB 170817A) was detected within a region of the sky consistent with the LIGO-Virgo-derived location of the gravitational-wave source. This sky region was subsequently observed by optical astronomy facilities, resulting in the identification of an optical transient signal within $\sim 10$ arcsec of the galaxy NGC 4993. These multi-messenger observations allow us to use GW170817 as a standard siren, the gravitational-wave analog of an astronomical standard candle, to measure the Hubble constant. This quantity, which represents the local expansion rate of the Universe, sets the overall scale of the Universe and is of fundamental importance to cosmology. Our measurement combines the distance to the source inferred purely from the gravitational-wave signal with the recession velocity inferred from measurements of the redshift using electromagnetic data. This approach does not require any form of cosmic "distance ladder;" the gravitational wave analysis can be used to estimate the luminosity distance out to cosmological scales directly, without the use of intermediate astronomical distance measurements. We determine the Hubble constant to be $70.0^{+12.0}_{-8.0} \, \mathrm{km} \, \mathrm{s}^{-1} \, \mathrm{Mpc}^{-1}$ (maximum a posteriori and 68% credible interval). This is consistent with existing measurements, while being completely independent of them. Additional standard-siren measurements from future gravitational-wave sources will provide precision constraints of this important cosmological parameter., Comment: 26 pages, 5 figures, Nature in press. For more information see https://dcc.ligo.org/LIGO-P1700296/public
- Published
- 2017
46. On the two-quasineutron rotational band in [formula omitted]Ba
- Author
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Petkov, P., Dewald, A., Kühn, R., Peusquens, R., Tonev, D., Kasemann, S., Zell, K.O., von Brentano, P., Bazzacco, D., Rossi-Alvarez, C., de Angelis, G., Lunardi, S., Pavan, P., and Napoli, D.R.
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- 2000
- Full Text
- View/download PDF
47. Heuristische Verfahren in der Portefeuilleplanung
- Author
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Kühn, R., Brockhoff, K., editor, Dinkelbach, W., editor, Kall, P., editor, Pressmar, D. B., editor, and Spicher, K., editor
- Published
- 1978
- Full Text
- View/download PDF
48. Pathogenese und Klinik okkulter Hodentumoren
- Author
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Kühn, R., Schott, G., Schmoll, Hans-Joachim, editor, and Weißbach, Lothar, editor
- Published
- 1988
- Full Text
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49. Die Bedeutung von Persönlichkeits-Merkmalen inklusive Streßreagibilität und Streßbewältigung für das Erleben operativer Eingriffe in Regionalanästhesie und die Rolle der Musik
- Author
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Sold, M., Schedel, R., Kühn, R., Spintge, Ralph, editor, and Droh, Roland, editor
- Published
- 1987
- Full Text
- View/download PDF
50. Optical Radiation Receivers
- Author
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Kühn, R. and Roth, Günter Dietmar, editor
- Published
- 1975
- Full Text
- View/download PDF
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