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6 results on '"Kugler, Carla-Maria"'

1. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

Author

Rücker, Frank G., Schlenk, Richard F., Bullinger, Lars, Kayser, Sabine, Teleanu, Veronica, Kett, Helena, Habdank, Marianne, Kugler, Carla-Maria, Holzmann, Karlheinz, Gaidzik, Verena I., Paschka, Peter, Held, Gerhard, von Lilienfeld-Toal, Marie, Lübbert, Michael, Fröhling, Stefan, Zenz, Thorsten, Krauter, Jürgen, Schlegelberger, Brigitte, Ganser, Arnold, Lichter, Peter, Döhner, Konstanze, and Döhner, Hartmut

Published
2012
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2. TP53 Alterations in Acute Myeloid Leukemia with Complex Karyotype Correlate with Specific Copy Number Alterations, Monosomal Karyotype, and Dismal Outcome,

Author

Rücker, Frank G., primary, Schlenk, Richard F., additional, Bullinger, Lars, additional, Kayser, Sabine, additional, Teleanu, Veronica, additional, Kett, Helena, additional, Habdank, Marianne, additional, Kugler, Carla-Maria, additional, Holzmann, Karlheinz, additional, Gaidzik, Verena I., additional, Paschka, Peter, additional, Held, Gerhard, additional, von Lilienfeld-Toal, Marie, additional, Lübbert, Michael, additional, Fröhling, Stefan, additional, Zenz, Thorsten, additional, Krauter, Jürgen, additional, Schlegelberger, Brigitte, additional, Ganser, Arnold, additional, Lichter, Peter, additional, Döhner, Konstanze, additional, and Döhner, Hartmut, additional

Published
2011
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3. In Acute Myeloid Leukemia with Complex Karyotype TP53 Alterations Are Associated with Specific Genomic Aberrations and Predict Inferior Survival.

Author

Rücker, Frank G, primary, Schlenk, Richard F, additional, Bullinger, Lars, additional, Kett, Helena, additional, Becker, Annegret, additional, Kugler, Carla-Maria, additional, Zenz, Thorsten, additional, Lichter, Peter, additional, Krauter, Jürgen, additional, Schlegelberger, Brigitte, additional, Ganser, Arnold, additional, Döhner, Hartmut, additional, and Döhner, Konstanze, additional

Published
2009
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4. TP53alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

Author

Rücker, Frank G., Schlenk, Richard F., Bullinger, Lars, Kayser, Sabine, Teleanu, Veronica, Kett, Helena, Habdank, Marianne, Kugler, Carla-Maria, Holzmann, Karlheinz, Gaidzik, Verena I., Paschka, Peter, Held, Gerhard, von Lilienfeld-Toal, Marie, Lübbert, Michael, Fröhling, Stefan, Zenz, Thorsten, Krauter, Jürgen, Schlegelberger, Brigitte, Ganser, Arnold, Lichter, Peter, Döhner, Konstanze, and Döhner, Hartmut

Abstract

To assess the frequency of TP53alterations and their correlation with other genetic changes and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed integrative analysis using TP53mutational screening and array-based genomic profiling in 234 CK-AMLs. TP53mutations were found in 141 of 234 (60%) and TP53losses were identified in 94 of 234 (40%) CK-AMLs; in total, 164 of 234 (70%) cases had TP53alterations. TP53-altered CK-AML were characterized by a higher degree of genomic complexity (aberrations per case, 14.30 vs 6.16; P< .0001) and by a higher frequency of specific copy number alterations, such as −5/5q−, −7/7q−, −16/16q−, −18/18q−, +1/+1p, and +11/+11q/amp11q13∼25; among CK-AMLs, TP53-altered more frequently exhibited a monosomal karyotype (MK). Patients with TP53alterations were older and had significantly lower complete remission rates, inferior event-free, relapse-free, and overall survival. In multivariable analysis for overall survival, TP53alterations, white blood cell counts, and age were the only significant factors. In conclusion, TP53is the most frequently known altered gene in CK-AML. TP53alterations are associated with older age, genomic complexity, specific DNA copy number alterations, MK, and dismal outcome. In multivariable analysis, TP53alteration is the most important prognostic factor in CK-AML, outweighing all other variables, including the MK category.

Published
2012
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5. TP53Alterations in Acute Myeloid Leukemia with Complex Karyotype Correlate with Specific Copy Number Alterations, Monosomal Karyotype, and Dismal Outcome,

Author

Rücker, Frank G., Schlenk, Richard F., Bullinger, Lars, Kayser, Sabine, Teleanu, Veronica, Kett, Helena, Habdank, Marianne, Kugler, Carla-Maria, Holzmann, Karlheinz, Gaidzik, Verena I., Paschka, Peter, Held, Gerhard, von Lilienfeld-Toal, Marie, Lübbert, Michael, Fröhling, Stefan, Zenz, Thorsten, Krauter, Jürgen, Schlegelberger, Brigitte, Ganser, Arnold, Lichter, Peter, Döhner, Konstanze, and Döhner, Hartmut

Abstract

Abstract 3558

Published
2011
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