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182 results on '"Kuku, Kayode O."'

5. Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study

Author

Yacob, Omar, Garcia-Garcia, Hector M., Dan, Kazuhiro, Soud, Mohamad, Adamo, Marianna, Picchi, Andrea, Sardella, Gennaro, Frigoli, Enrico, Limbruno, Ugo, Rigattieri, Stefano, Diletti, Roberto, Boccuzzi, Giacomo, Zimarino, Marco, Contarini, Marco, Russo, Filippo, Calabro, Paolo, Ando, Giuseppe, Varbella, Ferdinando, Garducci, Stefano, Palmieri, Cataldo, Briguori, Carlo, Kuku, Kayode O., Karagiannis, Alexios, and Valgimigli, Marco

Published
2021
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10. First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-Study

Author

Hideo-Kajita, Alexandre, Garcia-Garcia, Hector M., Haude, Michael, Joner, Michael, Koolen, Jacques, Ince, Hüseyin, Abizaid, Alexandre, Toelg, Ralph, Lemos, Pedro A., von Birgelen, Clemens, Christiansen, Evald Høj, Wijns, William, Neumann, Franz-Josef, Kaiser, Christoph, Eeckhout, Eric, Teik, Lim Soo, Escaned, Javier, Azizi, Viana, Kuku, Kayode O., Ozaki, Yuichi, Dan, Kazuhiro, and Waksman, Ron

Published
2019
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13. Development and Validation of a Protein Risk Score for Mortality in Heart Failure: A Community Cohort Study.

Author

Kuku, Kayode O., Shearer, Joseph J., Hashemian, Maryam, Oyetoro, Rebecca, Park, Hoyoung, Dulek, Brittany, Bielinski, Suzette J., Larson, Nicholas B., Ganz, Peter, Levy, Daniel, Psaty, Bruce M., Joo, Jungnam, and Roger, Véronique L.

Subjects
*HEART failure, *DISEASE risk factors, *BLOOD proteins, *COHORT analysis, *PEPTIDES, *HEART failure patients
Abstract

Proteomics offers great promise in improving risk prediction of patients with heart failure. In this community-based cohort study, 7289 plasma proteins were measured in 1351 patients to derive a protein risk score to predict mortality. The study showed that the protein score outperformed clinical risk tools in predicting mortality. Studies to further validate the score and determine risk thresholds for intervention now seem necessary. Visual Abstract. Development and Validation of a Protein Risk Score for Mortality in Heart Failure: Proteomics offers great promise in improving risk prediction of patients with heart failure. In this community-based cohort study, 7289 plasma proteins were measured in 1351 patients to derive a protein risk score to predict mortality. The study showed that the protein score outperformed clinical risk tools in predicting mortality. Studies to further validate the score and determine risk thresholds for intervention now seem necessary. Background: Heart failure (HF) is a complex clinical syndrome with high mortality. Current risk stratification approaches lack precision. High-throughput proteomics could improve risk prediction. Its use in clinical practice to guide the management of patients with HF depends on validation and evidence of clinical benefit. Objective: To develop and validate a protein risk score for mortality in patients with HF. Design: Community-based cohort. Setting: Southeast Minnesota. Participants: Patients with HF enrolled between 2003 and 2012 and followed through 2021. Measurements: A total of 7289 plasma proteins in 1351 patients with HF were measured using the SomaScan Assay (SomaLogic). A protein risk score was derived using least absolute shrinkage and selection operator regression and temporal validation in patients enrolled between 2003 and 2007 (development cohort) and 2008 and 2012 (validation cohort). Multivariable Cox regression was used to examine the association between the protein risk score and mortality. The performance of the protein risk score to predict 5-year mortality risk was assessed using calibration plots, decision curves, and relative utility analyses and compared with a clinical model, including the Meta‐Analysis Global Group in Chronic Heart Failure mortality risk score and N -terminal pro–B-type natriuretic peptide. Results: The development (n = 855; median age, 78 years; 50% women; 29% with ejection fraction <40%) and validation cohorts (n = 496; median age, 76 years; 45% women; 33% with ejection fraction <40%) were mostly similar. In the development cohort, 38 unique proteins were selected for the protein risk score. Independent of ejection fraction, the protein risk score demonstrated good calibration, reclassified mortality risk particularly at the extremes of the risk distribution, and showed greater clinical utility compared with the clinical model. Limitation: Participants were predominantly of European ancestry, potentially limiting the generalizability of the findings to different patient populations. Conclusion: Validation of the protein risk score demonstrated good calibration and evidence of predicted benefits to stratify the risk for death in HF superior to that of clinical methods. Further studies are needed to prospectively evaluate the score's performance in diverse populations and determine risk thresholds for interventions. Primary Funding Source: Division of Intramural Research at the National Heart, Lung, and Blood Institute of the National Institutes of Health. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Comparison of the Efficacy and Safety of Orbital and Rotational Atherectomy in Calcified Narrowings in Patients Who Underwent Percutaneous Coronary Intervention

Author

Koifman, Edward, Garcia-Garcia, Hector M., Kuku, Kayode O., Kajita, Alexandre H., Buchanan, Kyle D., Steinvil, Arie, Rogers, Toby, Bernardo, Nelson L., Lager, Robert, Gallino, Robert A., Ben-Dor, Itsik, Pichard, Augusto D., Torguson, Rebecca, Gai, Jiaxiang, Satler, Lowell F., and Waksman, Ron

Published
2018
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18. Intravascular ultrasound assessment of the effect of laser energy on the arterial wall during the treatment of femoro-popliteal lesions: a CliRpath excimer laser system to enlarge lumen openings (CELLO) registry study

Author

Kuku, Kayode O., Garcia-Garcia, Hector M., Koifman, Edward, Kajita, Alexandre H., Desale, Sameer, Azizi, Viana, Melaku, Gebremedhin, Bui, Anh, Meirovich, Yael F., Beyene, Solomon, Dheendsa, Aaphtaab, Schneider, Blaine, Waksman, Ron, and On behalf of the CELLO study investigators

Published
2018
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26. Comparison of Shear Stress Related to Neointimal Healing Between Ultrathin, Bioresorbable-Polymer Sirolimus-Eluting Stents Versus Thin, Durable-Polymer Everolimus-Eluting Stents in Patients Undergoing Coronary Revascularization: An Optical Coherence Tomography BIOFLOW II Substudy

Author

Beyene, Solomon, primary, Safi, Hannah, additional, Kuku, Kayode O., additional, Desale, Sameer, additional, Waksman, Ron, additional, Torii, Ryo, additional, Bourantas, Christos, additional, and Garcia-Garcia, Hector M., additional

Published
2022
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28. Human vs. Machine vs. Core Lab in Lumen and Vessel Contour Segmentation With Intravascular Ultrasound

Author

Bass, Ronald, primary, Garcia-Garcia, Hector M., additional, Sanz-Sanchez, Jorge, additional, Ziemer, Paulo G.P., additional, Bulant, Carlos A., additional, Kuku, Kayode O., additional, Kahsay, Yirga A., additional, Beyene, Solomon, additional, Melaku, Gebremedhin, additional, Otsuka, Tatsuhiko, additional, Choi, JooHee, additional, Fernandez-Peregrina, Estefania, additional, Erdogan, Emrah, additional, Gonzalo, Nieves, additional, Bourantas, Christos V., additional, Blanco, Pablo J., additional, and Raber, Lorenz, additional

Published
2022
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32. CRT-400.04 Human vs. Machine vs. Core Lab in Lumen and Vessel Contour Segmentation With Intravascular Ultrasound

Author

Bass, Ronald, primary, Garcia-Garcia, Hector M., additional, Sanz-Sanchez, Jorge, additional, Ziemer, Paulo GP., additional, Bulant, Carlos A., additional, Kuku, Kayode O., additional, Kahsay, Yirga A., additional, Beyene, Solomon, additional, Melaku, Gebremedhin, additional, Otsuka, Tatsuhiko, additional, Choi, JooHee, additional, Fernandez-Peregrina, Estefania, additional, Erdogan, Emrah, additional, Gonzalo, Nieves, additional, Bourantas, Christos V., additional, Blanco, Pablo J., additional, and Raber, Lorenz, additional

Published
2022
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36. Comparison of Angiographic and Intravascular Ultrasound Vessel Measurements in Infra-Popliteal Endovascular Interventions: The Below-the-Knee Calibration Study

Author

Kuku, Kayode O., primary, Garcia-Garcia, Hector M., additional, Finizio, Michael, additional, Melaku, Gebremedhin D., additional, Wilson, Vanessa A., additional, Beyene, Solomon S., additional, Kahsay, Yirga, additional, Jones-McMeans, Jennifer M., additional, Rapoza, Richard J., additional, Parikh, Sahil A., additional, DeRubertis, Brian G., additional, Varcoe, Ramon L., additional, and Adams, George L., additional

Published
2022
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39. Predicting future left anterior descending artery events from non-culprit lesions: insights from the Lipid-Rich Plaque study.

Author

Kuku, Kayode O, Garcia-Garcia, Hector M, Doros, Gheorghe, Mintz, Gary S, Ali, Ziad A, Skinner, William H, Artis, Andre K, Cate, Tim ten, Powers, Eric, Wong, Shing Chiu, Wykrzykowska, Joanna, Dube, Sandeep, Kazziha, Samer, van der Ent, Martin, Shah, Priti, Sum, Stephen, Torguson, Rebecca, Mario, Carlo Di, and Waksman, Ron

Subjects
MYOCARDIAL infarction risk factors, LIPID analysis, PUBLIC health surveillance, CONFIDENCE intervals, PERCUTANEOUS coronary intervention, ACUTE coronary syndrome, FORECASTING, CARDIAC arrest, CORONARY arteries, DISEASE risk factors
Abstract

Aims The left anterior descending (LAD) artery is the most frequently affected site by coronary artery disease. The prospective Lipid Rich Plaque (LRP) study, which enrolled patients undergoing imaging of non-culprits followed over 2 years, reported the successful identification of coronary segments at risk of future events based on near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) lipid signals. We aimed to characterize the plaque events involving the LAD vs. non-LAD segments. Methods and results LRP enrolled 1563 patients from 2014 to 2016. All adjudicated plaque events defined by the composite of cardiac death, cardiac arrest, non-fatal myocardial infarction, acute coronary syndrome, revascularization by coronary bypass or percutaneous coronary intervention, and rehospitalization for angina with >20% stenosis progression and reported as non-culprit lesion-related major adverse cardiac events (NC-MACE) were classified by NIRS-IVUS maxLCBI4 mm (maximum 4-mm Lipid Core Burden Index) ≤400 or >400 and association with high-risk-plaque characteristics, plaque burden ≥70%, and minimum lumen area (MLA) ≤4 mm2. Fifty-seven events were recorded with more lipid-rich plaques in the LAD vs. left circumflex and right coronary artery; 12.5% vs. 10.4% vs. 11.3%, P  = 0.097. Unequivocally, a maxLCBI4 mm >400 in the LAD was more predictive of NC-MACE [hazard ratio (HR) 4.32, 95% confidence interval (CI) (1.93–9.69); P  = 0.0004] vs. [HR 2.56, 95% CI (1.06–6.17); P  = 0.0354] in non-LAD segments. MLA ≤4 mm2 within the maxLCBI4 mm was significantly higher in the LAD (34.1% vs. 25.9% vs. 13.7%, P  < 0.001). Conclusion Non-culprit lipid-rich segments in the LAD were more frequently associated with plaque-level events. LAD NIRS-IVUS screening may help identify patients requiring intensive surveillance and medical treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Predicting future left anterior descending artery events from non-culprit lesions: insights from the Lipid-Rich Plaque study

Author

Kuku, Kayode O, primary, Garcia-Garcia, Hector M, additional, Doros, Gheorghe, additional, Mintz, Gary S, additional, Ali, Ziad A, additional, Skinner, William H, additional, Artis, Andre K, additional, ten Cate, Tim, additional, Powers, Eric, additional, Wong, Shing Chiu, additional, Wykrzykowska, Joanna, additional, Dube, Sandeep, additional, Kazziha, Samer, additional, van der Ent, Martin, additional, Shah, Priti, additional, Sum, Stephen, additional, Torguson, Rebecca, additional, Di Mario, Carlo, additional, and Waksman, Ron, additional

Published
2021
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41. Impact of Endothelial Shear Stress on Absorption Process of Resorbable Magnesium Scaffold: A BIOSOLVE-II Substudy

Author

Ozaki, Yuichi, primary, Kuku, Kayode O., additional, Sakellarios, Antonis, additional, Haude, Michael, additional, Hideo-Kajita, Alexandre, additional, Desale, Sameer, additional, Siogkas, Panagiotis, additional, Sioros, Spyros, additional, Ince, Hüseyin, additional, Abizaid, Alexandre, additional, Tölg, Ralph, additional, Lemos, Pedro Alves, additional, von Birgelen, Clemens, additional, Christiansen, Evald Høj, additional, Wijns, William, additional, Escaned, Javier, additional, Michalis, Lampros, additional, Fotiadis, Dimitrios I., additional, Djikstra, Jouke, additional, Waksman, Ron, additional, and Garcia-Garcia, Hector M., additional

Published
2021
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42. Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Amyloidosis Status

Author

Beyene, Solomon S., primary, Yacob, Omar, additional, Melaku, Gebremedhin D., additional, Hideo-Kajita, Alexandre, additional, Kuku, Kayode O., additional, Brathwaite, Echo, additional, Wilson, Vanessa, additional, Dan, Kazuhiro, additional, Kadakkal, Ajay, additional, Sheikh, Farooq, additional, Mohammed, Selma, additional, and Garcia-Garcia, Hector M., additional

Published
2021
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43. Optical Coherence Tomography based treatment approach for patients with Acute Coronary Syndrome

Author

Chezar-Azerrad, Chava, primary, Garcia-Garcia, Hector M., additional, Dan, Kazuhiro, additional, Barriola, Rodrigo, additional, Kuku, Kayode O., additional, Beyene, Solomon S., additional, Melaku, Gebremedhin D., additional, Shlofmitz, Evan, additional, Yerasi, Charan, additional, Case, Brian C., additional, Forrestal, Brian J., additional, Ben-Dor, Itsik, additional, Medranda, Giorgio A., additional, Hashim, Hayder, additional, De Maria, Giovanni Luigi, additional, Campos, Carlos M., additional, Bourantas, Christos, additional, and Waksman, Ron, additional

Published
2021
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44. Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study

Author

Yacob, Omar, primary, Garcia-Garcia, Hector M., additional, Dan, Kazuhiro, additional, Soud, Mohamad, additional, Adamo, Marianna, additional, Picchi, Andrea, additional, Sardella, Gennaro, additional, Frigoli, Enrico, additional, Limbruno, Ugo, additional, Rigattieri, Stefano, additional, Diletti, Roberto, additional, Boccuzzi, Giacomo, additional, Zimarino, Marco, additional, Contarini, Marco, additional, Russo, Filippo, additional, Calabro, Paolo, additional, Ando, Giuseppe, additional, Varbella, Ferdinando, additional, Garducci, Stefano, additional, Palmieri, Cataldo, additional, Briguori, Carlo, additional, Kuku, Kayode O., additional, Karagiannis, Alexios, additional, and Valgimigli, Marco, additional

Published
2020
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46. Comparison of plaque distribution and wire-free functional assessment in patients with stable angina and non-ST elevation myocardial infarction: an optical coherence tomography and quantitative flow ratio study

Author

Dan, Kazuhiro, primary, Garcia-Garcia, Hector M., additional, Yacob, Omar, additional, Kuku, Kayode O., additional, Kolm, Paul, additional, Shah, Nikunj, additional, Bennett, Martin R., additional, Curzen, Nick, additional, Waksman, Ron, additional, and Mahmoudi, Michael, additional

Published
2020
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48. CRT-500.01 Impact of Endothelial Shear Stress on Absorption Process of Resorbable Magnesium Scaffold: A BIOSOLVE-II Substudy

Author

Ozaki, Yuichi, primary, Kuku, Kayode O., additional, Sakellarios, Antonis, additional, Hideo-Kajita, Alexandre, additional, Desale, Sameer, additional, Siogkas, Panagiotis, additional, Sioros, Spyros, additional, Haude, Michael, additional, Ince, Hüseyin, additional, Abizaid, Alexandre, additional, Tölg, Ralph, additional, Lemos, Pedro Alves, additional, von Birgelen, Clemens, additional, Christiansen, Evald Høj, additional, Wijns, William, additional, Escaned, Javier, additional, Michalis, Lampros, additional, Fotiadis, Dimitrios I., additional, Waksman, Ron, additional, and Garcia-Garcia, Hector M., additional

Published
2020
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50. Comparison of quantitative flow ratio value of left anterior descending and circumflex coronary artery in patients with Takotsubo syndrome

Author

Ozaki, Yuichi, primary, Gonzalo, Nieves, additional, Salazar, Carlos Hernando, additional, Kuku, Kayode O., additional, Mejía-Rentería, Hernán, additional, Hideo-Kajita, Alexandre, additional, Núñez-Gil, Iván J., additional, Escaned, Javier, additional, Waksman, Ron, additional, and Garcia-Garcia, Hector M., additional

Published
2019
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