Search

Your search keyword '"Kulathinal, Rob J."' showing total 211 results
Start Over Author "Kulathinal, Rob J."
211 results on '"Kulathinal, Rob J."'

2. Designing a broad-spectrum integrative approach for cancer prevention and treatment

Author

Block, Keith I, Gyllenhaal, Charlotte, Lowe, Leroy, Amedei, Amedeo, Amin, ARM Ruhul, Amin, Amr, Aquilano, Katia, Arbiser, Jack, Arreola, Alexandra, Arzumanyan, Alla, Ashraf, S Salman, Azmi, Asfar S, Benencia, Fabian, Bhakta, Dipita, Bilsland, Alan, Bishayee, Anupam, Blain, Stacy W, Block, Penny B, Boosani, Chandra S, Carey, Thomas E, Carnero, Amancio, Carotenuto, Marianeve, Casey, Stephanie C, Chakrabarti, Mrinmay, Chaturvedi, Rupesh, Chen, Georgia Zhuo, Chen, Helen, Chen, Sophie, Chen, Yi Charlie, Choi, Beom K, Ciriolo, Maria Rosa, Coley, Helen M, Collins, Andrew R, Connell, Marisa, Crawford, Sarah, Curran, Colleen S, Dabrosin, Charlotta, Damia, Giovanna, Dasgupta, Santanu, DeBerardinis, Ralph J, Decker, William K, Dhawan, Punita, Diehl, Anna Mae E, Dong, Jin-Tang, Dou, Q Ping, Drew, Janice E, Elkord, Eyad, El-Rayes, Bassel, Feitelson, Mark A, Felsher, Dean W, Ferguson, Lynnette R, Fimognari, Carmela, Firestone, Gary L, Frezza, Christian, Fujii, Hiromasa, Fuster, Mark M, Generali, Daniele, Georgakilas, Alexandros G, Gieseler, Frank, Gilbertson, Michael, Green, Michelle F, Grue, Brendan, Guha, Gunjan, Halicka, Dorota, Helferich, William G, Heneberg, Petr, Hentosh, Patricia, Hirschey, Matthew D, Hofseth, Lorne J, Holcombe, Randall F, Honoki, Kanya, Hsu, Hsue-Yin, Huang, Gloria S, Jensen, Lasse D, Jiang, Wen G, Jones, Lee W, Karpowicz, Phillip A, Keith, W Nicol, Kerkar, Sid P, Khan, Gazala N, Khatami, Mahin, Ko, Young H, Kucuk, Omer, Kulathinal, Rob J, Kumar, Nagi B, Kwon, Byoung S, Le, Anne, Lea, Michael A, Lee, Ho-Young, Lichtor, Terry, Lin, Liang-Tzung, Locasale, Jason W, Lokeshwar, Bal L, Longo, Valter D, Lyssiotis, Costas A, MacKenzie, Karen L, Malhotra, Meenakshi, Marino, Maria, Martinez-Chantar, Maria L, and Matheu, Ander

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Rare Diseases, Precision Medicine, Aetiology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, Good Health and Well Being, Antineoplastic Agents, Phytogenic, Drug Resistance, Neoplasm, Genetic Heterogeneity, Humans, Molecular Targeted Therapy, Neoplasms, Signal Transduction, Tumor Microenvironment, Multi-targeted, Cancer hallmarks, Phytochemicals, Targeted therapy, Integrative medicine, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered.

Published
2015

9. Additional file 2 of Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals

Author

Richardson, Victorya, Engel, Nora, and Kulathinal, Rob J.

Abstract

Additional file 2: Table S1. Transcriptomic datasets used across developmental time and sex.. Table S2. Mouse sex-differential expression results. Table S3. Human sex-differential expression results. Table S4. NMF cluster size and number of genes per cluster. Table S5. Mouse male NMF coefficient matrix of gene expression data. Table S6. Mouse female NMF coefficient matrix of gene expression data. Table S7. Human male NMF coefficient matrix of gene expression data. Table S8. Human female NMF coefficient matrix of gene expression data. Table S9. Mouse male gene set enrichment analysis results of NMF clusters. Table S10. Mouse female gene set enrichment analysis results of NMF clusters. Table S11. Human male gene set enrichment analysis results of NMF clusters. Table S12. Human female gene set enrichment analysis results of NMF clusters. Table S13. Functional annotations of top 10 UMAP-positionally conserved genes between mouse and human from each developmental stage-adjacent group.

Published
2023
Full Text
View/download PDF

10. Additional file 1 of Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals

Author

Richardson, Victorya, Engel, Nora, and Kulathinal, Rob J.

Abstract

Additional file 1: Figure S1. Distributions of counts per gene for unfiltered and filtered expression data in mouse and human. Figure S2. Cophenetic correlation plots of NMF clusters across factorization rank, or the specified number of clusters inputted into NMF, in male mouseand female mouse. Figure S3. Cophenetic correlation plots of NMF clusters across factorization rank, or the specified number of clusters inputted into NMF, in male humanand female human. Figure S4. Average expression value of each gene from each NMF cluster metagene across samples in male and female mouse. Figure S5. Average expression value of each gene from each NMF cluster metagene across human samples of males and females. Figure S6. Genes with the highest and lowest principal component scores for the top 15 principal components of gene expression data in mouse. Figure S7. Genes with the highest and lowest principal component scores for the top 15 principal components of gene expression data in human. Figure S8. Bar plots of the number of interactions between each groupnormalized by the number of DEGs at each developmental stage. Figure S9. Median number of enriched NMF clusters per biological processGOSlim term, normalized by cluster size, between mouse male and female. Figure S10. Median number of enriched NMF clusters per biological processGOSlim term, normalized by cluster size, between human male and female. Figure S11. Median number of enriched NMF clusters per cellular componentGOSlim term, normalized by cluster size, between mouse male and female. Figure S12. Median number of enriched NMF clusters per cellular componentGOSlim term, normalized by cluster size, between human male and female. Figure S13. Median number of enriched NMF clusters per molecular functionGOSlim term, normalized by cluster size, between mouse male and female. Figure S14. Median number of enriched NMF clusters per molecular functionGOSlim term, normalized by cluster size, between human male and female. Figure S15. Median number of enriched NMF clusters per biological processGOSlim term, normalized by cluster size, between male mouse vs. humanand female mouse vs. human. Top five terms with the largest difference between mouse and human are labeled. Figure S16. Median number of enriched NMF clusters per cellular componentGOSlim term, normalized by cluster size, between male mouse vs. humanand female mouse vs. human. Top five terms with the largest difference between mouse and human are labeled. Figure S17. Median number of enriched NMF clusters per molecular functionGOSlim term, normalized by cluster size, between male mouse vs. humanand female mouse vs. human. Top five terms with the largest difference between mouse and human are labeled. Figure S18. Heatmap of the normalized number of NMF clusters enriched under each GOslim term for biological process. Figure S19. Heatmap of the normalized number of NMF clusters enriched under each GOslim term for cellular component. Figure S20. Heatmap of the normalized number of NMF clusters enriched under each GOslim term for molecular function.

Published
2023
Full Text
View/download PDF

18. Evolution of genes and genomes on the Drosophila phylogeny

Author

Clark, Andrew G., Eisen, Michael B., Smith, Douglas R., Bergman, Casey M., Oliver, Brian, Markow, Therese A., Kaufman, Thomas C., Kellis, Manolis, Gelbart, William, Iyer, Venky N., Pollard, Daniel A., Sackton, Timothy B., Larracuente, Amanda M., Singh, Nadia D., Abad, Jose P., Abt, Dawn N., Adryan, Boris, Aguade, Montserrat, Akashi, Hiroshi, Anderson, Wyatt W., Aquadro, Charles F., Ardell, David H., Arguello, Roman, Artieri, Carlo G., Barbash, Daniel A., Barker, Daniel, Barsanti, Paolo, Batterham, Phil, Batzoglou, Serafim, Begun, Dave, Bhutkar, Arjun, Blanco, Enrico, Bosak, Stephanie A., Bradley, Robert K., Brand, Adrianne D., Brent, Michael R., Brooks, Angela N., Brown, Randall H., Butlin, Roger K., Caggese, Corrado, Calvi, Brian R., Bernardo de Carvalho, A., Caspi, Anat, Castrezana, Sergio, Celniker, Susan E., Chang, Jean L., Chapple, Charles, Chatterji, Sourav, Chinwalla, Asif, Civetta, Alberto, Clifton, Sandra W., Comeron, Josep M., Costello, James C., Coyne, Jerry A., Daub, Jennifer, David, Robert G., Delcher, Arthur L., Delehaunty, Kim, Do, Chuong B., Ebling, Heather, Edwards, Kevin, Eickbush, Thomas, Evans, Jay D., Filipski, Alan, Findeiß, Sven, Freyhult, Eva, Fulton, Lucinda, Fulton, Robert, Garcia, Ana C. L., Gardiner, Anastasia, Garfield, David A., Garvin, Barry E., Gibson, Greg, Gilbert, Don, Gnerre, Sante, Godfrey, Jennifer, Good, Robert, Gotea, Valer, Gravely, Brenton, Greenberg, Anthony J., Griffiths-Jones, Sam, Gross, Samuel, Guigo, Roderic, Gustafson, Erik A., Haerty, Wilfried, Hahn, Matthew W., Halligan, Daniel L., Halpern, Aaron L., Halter, Gillian M., Han, Mira V., Heger, Andreas, Hillier, LaDeana, Hinrichs, Angie S., Holmes, Ian, Hoskins, Roger A., Hubisz, Melissa J., Hultmark, Dan, Huntley, Melanie A., Jaffe, David B., Jagadeeshan, Santosh, Jeck, William R., Johnson, Justin, Jones, Corbin D., Jordan, William C., Karpen, Gary H., Kataoka, Eiko, Keightley, Peter D., Kheradpour, Pouya, Kirkness, Ewen F., Koerich, Leonardo B., Kristiansen, Karsten, Kudrna, Dave, Kulathinal, Rob J., Kumar, Sudhir, Kwok, Roberta, Lander, Eric, Langley, Charles H., Lapoint, Richard, Lazzaro, Brian P., Lee, So-Jeong, Levesque, Lisa, Li, Ruiqiang, Lin, Chiao-Feng, Lin, Michael F., Lindblad-Toh, Kerstin, Llopart, Ana, Long, Manyuan, Low, Lloyd, Lozovsky, Elena, Lu, Jian, Luo, Meizhong, Machado, Carlos A., Makalowski, Wojciech, Marzo, Mar, Matsuda, Muneo, Matzkin, Luciano, McAllister, Bryant, McBride, Carolyn S., McKernan, Brendan, McKernan, Kevin, Mendez-Lago, Maria, Minx, Patrick, Mollenhauer, Michael U., Montooth, Kristi, Mount, Stephen M., Mu, Xu, Myers, Eugene, Negre, Barbara, Newfeld, Stuart, Nielsen, Rasmus, Noor, Mohamed A. F., O'Grady, Patrick, Pachter, Lior, Papaceit, Montserrat, Parisi, Matthew J., Parisi, Michael, Parts, Leopold, Pedersen, Jakob S., Pesole, Graziano, Phillippy, Adam M., Ponting, Chris P., Pop, Mihai, Porcelli, Damiano, Powell, Jeffrey R., Prohaska, Sonja, Pruitt, Kim, Puig, Marta, Quesneville, Hadi, Ravi Ram, Kristipati, Rand, David, Rasmussen, Matthew D., Reed, Laura K., Reenan, Robert, Reily, Amy, Remington, Karin A., Rieger, Tania T., Ritchie, Michael G., Robin, Charles, Rogers, Yu-Hui, Rohde, Claudia, Rozas, Julio, Rubenfield, Marc J., Ruiz, Alfredo, Russo, Susan, Salzberg, Steven L., Sanchez-Gracia, Alejandro, Saranga, David J., Sato, Hajime, Schaeffer, Stephen W., Schatz, Michael C., Schlenke, Todd, Schwartz, Russell, Segarra, Carmen, Singh, Rama S., Sirot, Laura, Sirota, Marina, Sisneros, Nicholas B., Smith, Chris D., Smith, Temple F., Spieth, John, Stage, Deborah E., Stark, Alexander, Stephan, Wolfgang, Strausberg, Robert L., Strempel, Sebastian, Sturgill, David, Sutton, Granger, Sutton, Granger G., Tao, Wei, Teichmann, Sarah, Tobari, Yoshiko N., Tomimura, Yoshihiko, Tsolas, Jason M., Valente, Vera L. S., Venter, Eli, Craig Venter, J., Vicario, Saverio, Vieira, Filipe G., Vilella, Albert J., Villasante, Alfredo, Walenz, Brian, Wang, Jun, Wasserman, Marvin, Watts, Thomas, Wilson, Derek, Wilson, Richard K., Wing, Rod A., Wolfner, Mariana F., Wong, Alex, Ka-Shu Wong, Gane, Wu, Chung-I, Wu, Gabriel, Yamamoto, Daisuke, Yang, Hsiao-Pei, Yang, Shiaw-Pyng, Yorke, James A., Yoshida, Kiyohito, Zdobnov, Evgeny, Zhang, Peili, Zhang, Yu, Zimin, Aleksey V., Baldwin, Jennifer, Abdouelleil, Amr, Abdulkadir, Jamal, Abebe, Adal, Abera, Brikti, Abreu, Justin, Christophe Acer, St, Aftuck, Lynne, Alexander, Allen, An, Peter, Anderson, Erica, Anderson, Scott, Arachi, Harindra, Azer, Marc, Bachantsang, Pasang, Barry, Andrew, Bayul, Tashi, Berlin, Aaron, Bessette, Daniel, Bloom, Toby, Blye, Jason, Boguslavskiy, Leonid, Bonnet, Claude, Boukhgalter, Boris, Bourzgui, Imane, Brown, Adam, Cahill, Patrick, Channer, Sheridon, Cheshatsang, Yama, Chuda, Lisa, Citroen, Mieke, Collymore, Alville, Cooke, Patrick, Costello, Maura, D'Aco, Katie, Daza, Riza, De Haan, Georgius, DeGray, Stuart, DeMaso, Christina, Dhargay, Norbu, Dooley, Kimberly, Dooley, Erin, Doricent, Missole, Dorje, Passang, Dorjee, Kunsang, Dupes, Alan, Elong, Richard, Falk, Jill, Farina, Abderrahim, Faro, Susan, Ferguson, Diallo, Fisher, Sheila, Foley, Chelsea D., Franke, Alicia, Friedrich, Dennis, Gadbois, Loryn, Gearin, Gary, Gearin, Christina R., Giannoukos, Georgia, Goode, Tina, Graham, Joseph, Grandbois, Edward, Grewal, Sharleen, Gyaltsen, Kunsang, Hafez, Nabil, Hagos, Birhane, Hall, Jennifer, Henson, Charlotte, Hollinger, Andrew, Honan, Tracey, Huard, Monika D., Hughes, Leanne, Hurhula, Brian, Erii Husby, M, Kamat, Asha, Kanga, Ben, Kashin, Seva, Khazanovich, Dmitry, Kisner, Peter, Lance, Krista, Lara, Marcia, Lee, William, Lennon, Niall, Letendre, Frances, LeVine, Rosie, Lipovsky, Alex, Liu, Xiaohong, Liu, Jinlei, Liu, Shangtao, Lokyitsang, Tashi, Lokyitsang, Yeshi, Lubonja, Rakela, Lui, Annie, MacDonald, Pen, Magnisalis, Vasilia, Maru, Kebede, Matthews, Charles, McCusker, William, McDonough, Susan, Mehta, Teena, Meldrim, James, Meneus, Louis, Mihai, Oana, Mihalev, Atanas, Mihova, Tanya, Mittelman, Rachel, Mlenga, Valentine, Montmayeur, Anna, Mulrain, Leonidas, Navidi, Adam, Naylor, Jerome, Negash, Tamrat, Nguyen, Thu, Nguyen, Nga, Nicol, Robert, Norbu, Choe, Norbu, Nyima, Novod, Nathaniel, O'Neill, Barry, Osman, Sahal, Markiewicz, Eva, Oyono, Otero L., Patti, Christopher, Phunkhang, Pema, Pierre, Fritz, Priest, Margaret, Raghuraman, Sujaa, Rege, Filip, Reyes, Rebecca, Rise, Cecil, Rogov, Peter, Ross, Keenan, Ryan, Elizabeth, Settipalli, Sampath, Shea, Terry, Sherpa, Ngawang, Shi, Lu, Shih, Diana, Sparrow, Todd, Spaulding, Jessica, Stalker, John, Stange-Thomann, Nicole, Stavropoulos, Sharon, Stone, Catherine, Strader, Christopher, Tesfaye, Senait, Thomson, Talene, Thoulutsang, Yama, Thoulutsang, Dawa, Topham, Kerri, Topping, Ira, Tsamla, Tsamla, Vassiliev, Helen, Vo, Andy, Wangchuk, Tsering, Wangdi, Tsering, Weiand, Michael, Wilkinson, Jane, Wilson, Adam, Yadav, Shailendra, Young, Geneva, Yu, Qing, Zembek, Lisa, Zhong, Danni, Zimmer, Andrew, Zwirko, Zac, Alvarez, Pablo, Brockman, Will, Butler, Jonathan, Chin, CheeWhye, Grabherr, Manfred, Kleber, Michael, Mauceli, Evan, and MacCallum, Iain

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Drosophila 12 Genomes Consortium; Project Leaders; Andrew G. Clark (corresponding author) [1]; Michael B. Eisen (corresponding author) [2, 3]; Douglas R. Smith (corresponding author) [4]; Casey M. Bergman (corresponding [...]

Published
2007
Full Text
View/download PDF

19. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

Author

Stark, Alexander, Lin, Michael F., Kheradpour, Pouya, Pedersen, Jakob S., Parts, Leopold, Carlson, Joseph W., Crosby, Madeline A., Rasmussen, Matthew D., Roy, Sushmita, Deoras, Ameya N., Ruby, J. Graham, Brennecke, Julius, Matthews, Beverley B., Schroeder, Andrew J., Sian Gramates, L., St Pierre, Susan E., Roark, Margaret, Wiley Jr, Kenneth L., Kulathinal, Rob J., Zhang, Peili, Myrick, Kyl V., Antone, Jerry V., Gelbart, William M., Yu, Charles, Park, Soo, Wan, Kenneth H., Celniker, Susan E., Hodges, Emily, Hinrichs, Angie S., Caspi, Anat, Paten, Benedict, Park, Seung-Won, Han, Mira V., Maeder, Morgan L., Polansky, Benjamin J., Robson, Bryanne E., Aerts, Stein, van Helden, Jacques, Hassan, Bassem, Gilbert, Donald G., Eastman, Deborah A., Rice, Michael, Weir, Michael, Hahn, Matthew W., Park, Yongkyu, Dewey, Colin N., Pachter, Lior, Kent, W. James, Haussler, David, Lai, Eric C., Bartel, David P., Hannon, Gregory J., Kaufman, Thomas C., Eisen, Michael B., Clark, Andrew G., Smith, Douglas, and Kellis, Manolis

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Alexander Stark [1, 2, 35]; Michael F. Lin [1, 2, 35]; Pouya Kheradpour [2, 35]; Jakob S. Pedersen [3, 4, 35]; Leopold Parts [5, 6]; Joseph W. Carlson [7]; [...]

Published
2007
Full Text
View/download PDF

20. Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila

Author

Haerty, Wilfried, Jagadeeshan, Santosh, Kulathinal, Rob J., Wong, Alex, Ram, Kristipati Ravi, Sirot, Laura K., Levesque, Lisa, Artieri, Carlo G., Wolfner, Mariana F., Civetta, Alberto, and Singh, Rama S.

Subjects
Drosophila -- Genetic aspects, Gene expression -- Research, Evolution -- Genetic aspects, Biological sciences
Abstract

A large portion of the annotated genes in Drosophila melanogaster show sex-biased expression, indicating that sex and reproduction-related genes (SRR genes) represent an appreciable component of the genome. Previous studies, in which subsets of genes were compared among few Drosophila species, have found that SRR genes exhibit unusual evolutionary patterns. Here, we have used the newly released genome sequences from 12 Drosophila species, coupled to a larger set of SRR genes, to comprehensively test the generality of these patterns. Among 2505 SRR genes examined, including ESTs with biased expression in reproductive tissues and genes characterized as involved in gametogenesis, we find that a relatively high proportion of SRR genes have experienced accelerated divergence throughout the genus Drosophila. Several testis-specific genes, male seminal fluid proteins (SFPs), and spermatogenesis genes show lineage-specific bursts of accelerated evolution and positive selection. SFP genes also show evidence of lineage-specific gene loss and/ or gain. These results bring us closer to understanding the details of the evolutionary dynamics of SRR genes with respect to species divergence.

Published
2007

21. Male sex drive and the masculinization of the genome

Author

Singh, Rama S. and Kulathinal, Rob J.

Subjects
Fitness (Genetics) -- Research, Genetic variation -- Research, Sexual selection in animals -- Research, Virilism -- Research, Biological sciences
Abstract

A proposal is made that male sex drive directly impacts the genome by leading to its progressive masculinization, genes that possess sex-specific effects on male fitness accumulate to a larger extent and are generally more diverged. Male sex-drive theory complements the female-choice theory of sexual selection and allows for the genetic variation of costly sexual traits to be continuously replenished.

Published
2005

24. Introduction

Author

Singh, Rama S., primary, Xu, Jianping, additional, and Kulathinal, Rob J., additional

Published
2012
Full Text
View/download PDF

30. Commemorating the 20th century Darwin: Ernst Mayr's words and thoughts, five years later

Author

Kulathinal, Rob J.

Subjects
Mayr, Ernst, Biologists, Biological sciences
Abstract

It has been five years since Ernst Mayr, one of the most influential evolutionary biologists of the last century, passed away. Mayr's seminal work as a naturalist and, in particular, as a bird systematist allowed him to approach the species problem in a revolutionary way. As a leading architect of the Modern Evolutionary Synthesis, Mayr helped integrate Darwinian theory with the broad fields of systematics and genetics. We pay tribute to this legend by publishing an interview taken shortly before his death. Key words: neo-Darwinian theory, evolution, speciation, history of science. Cela fait cinq ans qu'est decede Ernst Mayr, l'un des biologistes de revolution parmi les plus influents du dernier siecle. L'oeuvre phare de Mayr en tant que naturaliste et en particulier en matiere de systematique des oiseaux, lui a permis d'approcher le probleme des especes d'une maniere revolutionnaire. En tant qu'architecte principal de la Synthase moderne en evolution, Mayr a aide; a integrer la theorie darwinienne aux champs plus vastes de la systematique et de la genetique. Les auteurs rendent hommage a ce scientifique legendaire en rendant public une entrevue realisee avant sa mort. Mots-cles: theorie neo-darwinienne, evolution, speciation, histoire des sciences. [Traduit par la Redaction], Last year's scores of tributes in honour of Charles Darwin and his 'Abstract', On the Origin of Species, highlighted how the study of evolution imparts a comprehensive and cohesive understanding [...]

Published
2010
Full Text
View/download PDF

31. Developing a community-based genetic nomenclature for anole lizards

Author

Kusumi Kenro, Kulathinal Rob J, Abzhanov Arhat, Boissinot Stephane, Crawford Nicholas G, Faircloth Brant C, Glenn Travis C, Janes Daniel E, Losos Jonathan B, Menke Douglas B, Poe Steven, Sanger Thomas J, Schneider Christopher J, Stapley Jessica, Wade Juli, and Wilson-Rawls Jeanne

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Comparative studies of amniotes have been hindered by a dearth of reptilian molecular sequences. With the genomic assembly of the green anole, Anolis carolinensis available, non-avian reptilian genes can now be compared to mammalian, avian, and amphibian homologs. Furthermore, with more than 350 extant species in the genus Anolis, anoles are an unparalleled example of tetrapod genetic diversity and divergence. As an important ecological, genetic and now genomic reference, it is imperative to develop a standardized Anolis gene nomenclature alongside associated vocabularies and other useful metrics. Results Here we report the formation of the Anolis Gene Nomenclature Committee (AGNC) and propose a standardized evolutionary characterization code that will help researchers to define gene orthology and paralogy with tetrapod homologs, provide a system for naming novel genes in Anolis and other reptiles, furnish abbreviations to facilitate comparative studies among the Anolis species and related iguanid squamates, and classify the geographical origins of Anolis subpopulations. Conclusions This report has been generated in close consultation with members of the Anolis and genomic research communities, and using public database resources including NCBI and Ensembl. Updates will continue to be regularly posted to new research community websites such as lizardbase. We anticipate that this standardized gene nomenclature will facilitate the accessibility of reptilian sequences for comparative studies among tetrapods and will further serve as a template for other communities in their sequencing and annotation initiatives.

Published
2011
Full Text
View/download PDF

32. Using comparative genomic hybridization to survey genomic sequence divergence across species: a proof-of-concept from Drosophila

Author

Kulathinal Rob J, Soneji Kosha, Jones Albyn, Machado Heather E, Renn Suzy CP, and Hofmann Hans A

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Genome-wide analysis of sequence divergence among species offers profound insights into the evolutionary processes that shape lineages. When full-genome sequencing is not feasible for a broad comparative study, we propose the use of array-based comparative genomic hybridization (aCGH) in order to identify orthologous genes with high sequence divergence. Here we discuss experimental design, statistical power, success rate, sources of variation and potential confounding factors. We used a spotted PCR product microarray platform from Drosophila melanogaster to assess sequence divergence on a gene-by-gene basis in three fully sequenced heterologous species (D. sechellia, D. simulans, and D. yakuba). Because complete genome assemblies are available for these species this study presents a powerful test for the use of aCGH as a tool to measure sequence divergence. Results We found a consistent and linear relationship between hybridization ratio and sequence divergence of the sample to the platform species. At higher levels of sequence divergence (< 92% sequence identity to D. melanogaster) ~84% of features had significantly less hybridization to the array in the heterologous species than the platform species, and thus could be identified as "diverged". At lower levels of divergence (≥ 97% identity), only 13% of genes were identified as diverged. While ~40% of the variation in hybridization ratio can be accounted for by variation in sequence identity of the heterologous sample relative to D. melanogaster, other individual characteristics of the DNA sequences, such as GC content, also contribute to variation in hybridization ratio, as does technical variation. Conclusions Here we demonstrate that aCGH can accurately be used as a proxy to estimate genome-wide divergence, thus providing an efficient way to evaluate how evolutionary processes and genomic architecture can shape species diversity in non-model systems. Given the increased number of species for which microarray platforms are available, comparative studies can be conducted for many interesting lineages in order to identify highly diverged genes that may be the target of natural selection.

Published
2010
Full Text
View/download PDF

33. Integrative Genomic Analysis Identifies Ancestry-Related Expression Quantitative Trait Loci on DNA Polymerase beta and Supports the Association of Genetic Ancestry With Survival Disparities in Head and Neck Squamous Cell Carcinoma

Author

Ramakodi, Meganathan P., Devarajan, Karthik, Blackman, Elizabeth, Gibbs, Denise, Luce, Danièle, Deloumeaux, Jacqueline, Duflo, Suzy, Liu, Jeffrey C., Mehra, Ranee, Kulathinal, Rob J., Ragin, Camille C., Fox Chase Cancer Center, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), African Caribbean Cancer Consortium [Pointe-à-Pitre, Guadeloupe], CHU Pointe-à-Pitre/Abymes [Guadeloupe], Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), American Cancer Society [RSG-14-033-01-CPPB], National Cancer Institute [CA006927], William J. Avery Postdoctoral Research Fellowship, French National Cancer Institute, and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
survival disparity, dna polymerase beta, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, head and neck squamous cell carcinoma, expression quantitative trait locus (eqtl), genetic ancestry
Abstract

International audience; BACKGROUND: African Americans with head and neck squamous cell carcinoma (HNSCC) have a lower survival rate than whites. This study investigated the functional importance of ancestry-informative single-nucleotide polymorphisms (SNPs) in HNSCC and also examined the effect of functionally important genetic elements on racial disparities in HNSCC survival. METHODS: Ancestry-informative SNPs, RNA sequencing, methylation, and copy number variation data for 316 oral cavity and laryngeal cancer patients were analyzed across 178 DNA repair genes. The results of expression quantitative trait locus (eQTL) analyses were also replicated with a Gene Expression Omnibus (GEO) data set. The effects of eQTLs on overall survival (OS) and disease-free survival (DFS) were evaluated. RESULTS: Five ancestry-related SNPs were identified as cis-eQTLs in the DNA polymerase beta (POLB) gene (false discovery rate [FDR]

Published
2017

34. Integrative genomics analysis identifies ancestral-related eQTLs on POLB, and supports the association of genetic ancestry with survival disparity in HNSCC

Author

Ramakodi, Meganathan P., Devarajan, Karthik, Blackman, Elizabeth, Gibbs, Denise, Luce, Danièle, Deloumeaux, Jacqueline, Duflo, Suzy, Liu, Jeffrey C., Mehra, Ranee, Kulathinal, Rob J., and Ragin, Camille C.

Subjects
Adult, Male, Mouth, DNA Copy Number Variations, Genotype, Sequence Analysis, RNA, Squamous Cell Carcinoma of Head and Neck, Quantitative Trait Loci, Middle Aged, Polymorphism, Single Nucleotide, Article, Disease-Free Survival, White People, Black or African American, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Humans, Female, Laryngeal Neoplasms, Alleles, DNA Polymerase beta, Genetic Association Studies, Aged
Abstract

African Americans with head and neck squamous cell carcinoma (HNSCC) have a lower survival rate than whites. This study investigated the functional importance of ancestry-informative single-nucleotide polymorphisms (SNPs) in HNSCC and also examined the effect of functionally important genetic elements on racial disparities in HNSCC survival.Ancestry-informative SNPs, RNA sequencing, methylation, and copy number variation data for 316 oral cavity and laryngeal cancer patients were analyzed across 178 DNA repair genes. The results of expression quantitative trait locus (eQTL) analyses were also replicated with a Gene Expression Omnibus (GEO) data set. The effects of eQTLs on overall survival (OS) and disease-free survival (DFS) were evaluated.Five ancestry-related SNPs were identified as cis-eQTLs in the DNA polymerase β (POLB) gene (false discovery rate [FDR] 0.01). The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002). An association was observed between these eQTLs and OS (P .037; FDR 0.0363) as well as DFS (P = .018 to .0629; FDR 0.079) for oral cavity and laryngeal cancer patients treated with platinum-based chemotherapy and/or radiotherapy. Genotypes containing the African allele were associated with poor OS/DFS in comparison with homozygous genotypes harboring the white allele.Analyses show that ancestry-related alleles could act as eQTLs in HNSCC and support the association of ancestry-related genetic factors with survival disparities in patients diagnosed with oral cavity and laryngeal cancer. Cancer 2017;123:849-60. © 2016 American Cancer Society.

Published
2016

36. Comparative Genomics Reveals Accelerated Evolution in Conserved Pathways during the Diversification of Anole Lizards

Author

Tollis, Marc, primary, Hutchins, Elizabeth D, additional, Stapley, Jessica, additional, Rupp, Shawn M, additional, Eckalbar, Walter L, additional, Maayan, Inbar, additional, Lasku, Eris, additional, Infante, Carlos R, additional, Dennis, Stuart R, additional, Robertson, Joel A, additional, May, Catherine M, additional, Crusoe, Michael R, additional, Bermingham, Eldredge, additional, DeNardo, Dale F, additional, Hsieh, Shi-Tong Tonia, additional, Kulathinal, Rob J, additional, McMillan, William Owen, additional, Menke, Douglas B, additional, Pratt, Stephen C, additional, Rawls, Jeffery Alan, additional, Sanjur, Oris, additional, Wilson-Rawls, Jeanne, additional, Wilson Sayres, Melissa A, additional, Fisher, Rebecca E, additional, and Kusumi, Kenro, additional

Published
2018
Full Text
View/download PDF

39. Integrative genomic analysis identifies ancestry‐related expression quantitative trait loci on DNA polymerase β and supports the association of genetic ancestry with survival disparities in head and neck squamous cell carcinoma

Author

Ramakodi, Meganathan P., primary, Devarajan, Karthik, additional, Blackman, Elizabeth, additional, Gibbs, Denise, additional, Luce, Danièle, additional, Deloumeaux, Jacqueline, additional, Duflo, Suzy, additional, Liu, Jeffrey C., additional, Mehra, Ranee, additional, Kulathinal, Rob J., additional, and Ragin, Camille C., additional

Published
2016
Full Text
View/download PDF

40. Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes

Author

Lin, Michael, F., Carlson, Joseph W., Crosby, Madeline A., Matthews, Beverley B., Yu, Charles, Park, Soo, Wan, Kenneth H., Schroeder, Andrew J., Gramates, L. Sian, Pierre, Susan E., Roark, Margaret, Wiley, Kenneth L., Jr., Kulathinal, Rob J., Peili Zhang, Myrick, Kyl V., Antone, Jerry V., Celniker, Susan E., and Gelbart, William M.

Subjects
Drosophila -- Genetic aspects, Genomics -- Research, Messenger RNA -- Research, Genetic translation -- Research, Health
Abstract

The findings from comparative genomic studies from 12 Drosophila species, which provide insight into protein-coding exons in the Drosophila melanogaster genome, are discussed.

Published
2007

46. Designing a broad-spectrum integrative approach for cancer prevention and treatment

Author

Block, Keith I., Gyllenhaal, Charlotte, Lowe, Leroy, Amedei, Amedeo, Ruhul Amin, A. R. M., Amin, Amr, Aquilano, Katia, Arbiser, Jack, Arreola, Alexandra, Arzumanyan, Alla, Salman Ashraf, S., Azmi, Asfar S., Benencia, Fabian, Bhakta, Dipita, Bilsland, Alan, Bishayeen, Anupam, Blain, Stacy W., Block, Penny B., Boosani, Chandra S., Carey, Thomas E., Carnero, Amancio, Carotenuto, Marianeve, Casey, Stephanie C., Chakrabarti, Mrinmay, Chaturvedi, Rupesh, Zhuo Chen, Georgia, Chenx, Helen, Chen, Sophie, Charlie Chen, Yi, Choi, Beom K., Rosa Ciriolo, Maria, Coley, Helen M., Collins, Andrew R., Connell, Marisa, Crawford, Sarah, Curran, Colleen S., Dabrosin, Charlotta, Damia, Giovanna, Dasgupta, Santanu, DeBerardinis, Ralph J., Decker, William K., Dhawan, Punita, Diehl, Anna Mae E., Dong, Jin-Tang, Ping Dou, Q., Drew, Janice E., Elkord, Eyad, El-Rayes, Bassel, Feitelson, Mark A., Felsher, Dean W., Ferguson, Lynnette R., Fimognari, Carmela, Firestone, Gary L., Frezza, Christian, Fujii, Hiromasa, Fuster, Mark M., Generali, Daniele, Georgakilas, Alexandros G., Gieseler, Frank, Gilbertson, Michael, Green, Michelle F., Grue, Brendan, Guha, Gunjan, Halicka, Dorota, Helferich, William G., Heneberg, Petr, Hentosh, Patricia, Hirschey, Matthew D., Hofseth, Lorne J., Holcombe, Randall F., Honoki, Kanya, Hsu, Hsue-Yin, Huang, Gloria S., Jensen, Lasse D., Jiang, Wen G., Jones, Lee W., Karpowicz, Phillip A., Nicol Keith, W., Kerkar, Sid P., Khan, Gazala N., Khatami, Mahin, Ko, Young H., Kucuk, Omer, Kulathinal, Rob J., Kumar, Nagi B., Kwon, Byoung S., Le, Anne, Lea, Michael A., Lee, Ho-Young, Lichtor, Terry, Lin, Liang-Tzung, Locasale, Jason W., Lokeshwar, Bal L., Longo, Valter D., Lyssiotis, Costas A., MacKenzie, Karen L., Malhotra, Meenakshi, Marino, Maria, Martinez-Chantar, Maria L., Matheu, Ander, Maxwell, Christopher, McDonnell, Eoin, Meeker, Alan K., Mehrmohamadi, Mahya, Mehta, Kapil, Michelotti, Gregory A., Mohammad, Ramzi M., Mohammed, Sulma I., James Morre, D., Muqbil, Irfana, Muralidhar, Vinayak, Murphy, Michael P., Purnachandra Nagaraju, Ganji, Nahta, Rita, Niccolai, Elena, Nowsheen, Somaira, Panis, Carolina, Pantano, Francesco, Parslow, Virginia R., Pawelec, Graham, Pedersen, Peter L., Poore, Brad, Poudyal, Deepak, Prakash, Satya, Prince, Mark, Raffaghello, Lizzia, Rathmell, Jeffrey C., Kimryn Rathmell, W., Ray, Swapan K., Reichrath, Joerg, Rezazadeh, Sarallah, Ribatti, Domenico, Ricciardiello, Luigi, Brooks Robey, R., Rodier, Francis, Vasantha Rupasinghe, H. P., Luigi Russo, Gian, Ryan, Elizabeth P., Samadi, Abbas K., Sanchez-Garcia, Isidro, Sanders, Andrew J., Santini, Daniele, Sarkar, Malancha, Sasada, Tetsuro, Saxena, Neeraj K., Shackelford, Rodney E., Shantha Kumara, H. M. C., Sharma, Dipali, Shin, Dong M., Sidransky, David, David Siegelin, Markus, Signori, Emanuela, Singh, Neetu, Sivanand, Sharanya, Sliva, Daniel, Smythe, Carl, Spagnuolo, Carmela, Stafforini, Diana M., Stagg, John, Subbarayan, Pochi R., Sundin, Tabetha, Talib, Wamidh H., Thompson, Sarah K., Tran, Phuoc T., Ungefroren, Hendrik, Vander Heiden, Matthew G., Venkateswaran, Vasundara, Vinay, Dass S., Vlachostergios, Panagiotis J., Wang, Zongwei, Wellendx, Kathryn E., Whelan, Richard L., Yang, Eddy S., Yang, Huanjie, Yang, Xujuan, Yaswen, Paul, Yedjou, Clement, Yin, Xin, Zhu, Jiyue, Zollo, Massimo, Block, Keith I., Gyllenhaal, Charlotte, Lowe, Leroy, Amedei, Amedeo, Ruhul Amin, A. R. M., Amin, Amr, Aquilano, Katia, Arbiser, Jack, Arreola, Alexandra, Arzumanyan, Alla, Salman Ashraf, S., Azmi, Asfar S., Benencia, Fabian, Bhakta, Dipita, Bilsland, Alan, Bishayeen, Anupam, Blain, Stacy W., Block, Penny B., Boosani, Chandra S., Carey, Thomas E., Carnero, Amancio, Carotenuto, Marianeve, Casey, Stephanie C., Chakrabarti, Mrinmay, Chaturvedi, Rupesh, Zhuo Chen, Georgia, Chenx, Helen, Chen, Sophie, Charlie Chen, Yi, Choi, Beom K., Rosa Ciriolo, Maria, Coley, Helen M., Collins, Andrew R., Connell, Marisa, Crawford, Sarah, Curran, Colleen S., Dabrosin, Charlotta, Damia, Giovanna, Dasgupta, Santanu, DeBerardinis, Ralph J., Decker, William K., Dhawan, Punita, Diehl, Anna Mae E., Dong, Jin-Tang, Ping Dou, Q., Drew, Janice E., Elkord, Eyad, El-Rayes, Bassel, Feitelson, Mark A., Felsher, Dean W., Ferguson, Lynnette R., Fimognari, Carmela, Firestone, Gary L., Frezza, Christian, Fujii, Hiromasa, Fuster, Mark M., Generali, Daniele, Georgakilas, Alexandros G., Gieseler, Frank, Gilbertson, Michael, Green, Michelle F., Grue, Brendan, Guha, Gunjan, Halicka, Dorota, Helferich, William G., Heneberg, Petr, Hentosh, Patricia, Hirschey, Matthew D., Hofseth, Lorne J., Holcombe, Randall F., Honoki, Kanya, Hsu, Hsue-Yin, Huang, Gloria S., Jensen, Lasse D., Jiang, Wen G., Jones, Lee W., Karpowicz, Phillip A., Nicol Keith, W., Kerkar, Sid P., Khan, Gazala N., Khatami, Mahin, Ko, Young H., Kucuk, Omer, Kulathinal, Rob J., Kumar, Nagi B., Kwon, Byoung S., Le, Anne, Lea, Michael A., Lee, Ho-Young, Lichtor, Terry, Lin, Liang-Tzung, Locasale, Jason W., Lokeshwar, Bal L., Longo, Valter D., Lyssiotis, Costas A., MacKenzie, Karen L., Malhotra, Meenakshi, Marino, Maria, Martinez-Chantar, Maria L., Matheu, Ander, Maxwell, Christopher, McDonnell, Eoin, Meeker, Alan K., Mehrmohamadi, Mahya, Mehta, Kapil, Michelotti, Gregory A., Mohammad, Ramzi M., Mohammed, Sulma I., James Morre, D., Muqbil, Irfana, Muralidhar, Vinayak, Murphy, Michael P., Purnachandra Nagaraju, Ganji, Nahta, Rita, Niccolai, Elena, Nowsheen, Somaira, Panis, Carolina, Pantano, Francesco, Parslow, Virginia R., Pawelec, Graham, Pedersen, Peter L., Poore, Brad, Poudyal, Deepak, Prakash, Satya, Prince, Mark, Raffaghello, Lizzia, Rathmell, Jeffrey C., Kimryn Rathmell, W., Ray, Swapan K., Reichrath, Joerg, Rezazadeh, Sarallah, Ribatti, Domenico, Ricciardiello, Luigi, Brooks Robey, R., Rodier, Francis, Vasantha Rupasinghe, H. P., Luigi Russo, Gian, Ryan, Elizabeth P., Samadi, Abbas K., Sanchez-Garcia, Isidro, Sanders, Andrew J., Santini, Daniele, Sarkar, Malancha, Sasada, Tetsuro, Saxena, Neeraj K., Shackelford, Rodney E., Shantha Kumara, H. M. C., Sharma, Dipali, Shin, Dong M., Sidransky, David, David Siegelin, Markus, Signori, Emanuela, Singh, Neetu, Sivanand, Sharanya, Sliva, Daniel, Smythe, Carl, Spagnuolo, Carmela, Stafforini, Diana M., Stagg, John, Subbarayan, Pochi R., Sundin, Tabetha, Talib, Wamidh H., Thompson, Sarah K., Tran, Phuoc T., Ungefroren, Hendrik, Vander Heiden, Matthew G., Venkateswaran, Vasundara, Vinay, Dass S., Vlachostergios, Panagiotis J., Wang, Zongwei, Wellendx, Kathryn E., Whelan, Richard L., Yang, Eddy S., Yang, Huanjie, Yang, Xujuan, Yaswen, Paul, Yedjou, Clement, Yin, Xin, Zhu, Jiyue, and Zollo, Massimo

Abstract

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broadspectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address s, Funding Agencies|Terry Fox Foundation Grant [TF-13-20]; UAEU Program for Advanced Research (UPAR) [31S118]; NIH [AR47901, R21CA188818, R15 CA137499-01, F32CA177139, P20RR016477, P20GM103434, R01CA170378, U54CA149145, U54CA143907, R01-HL107652, R01CA166348, R01GM071725, R01 CA109335-04A1, 109511R01CA151304CA168997 A11106131R03CA1711326 1P01AT003961RO1 CA100816P01AG034906 R01AG020642P01AG034906-01A1R01HL108006]; NIH NRSA Grant [F31CA154080]; NIH (NIAID) R01: Combination therapies for chronic HBV, liver disease, and cancer [AI076535]; Sky Foundation Inc. Michigan; University of Glasgow; Beatson Oncology Centre Fund; Spanish Ministry of Economy and Competitivity, ISCIII [PI12/00137, RTICC: RD12/0036/0028]; FEDER from Regional Development European Funds (European Union), Consejeria de Ciencia e Innovacion [CTS-6844, CTS-1848]; Consejeria de Salud of the Junta de Andalucia [PI-0135-2010, PI-0306-2012]; ISCIII [PIE13/0004]; FEDER funds; United Soybean Board; NIH NCCAM Grant [K01AT007324]; NIH NCI Grant [R33 CA161873-02]; Michael Cuccione Childhood Cancer Foundation Graduate Studentship; Ovarian and Prostate Cancer Research Trust, UK; West Virginia Higher Education Policy Commission/Division of Science Research; National Institutes of Health; Italian Association for Cancer Research (AIRC) [IG10636, 15403]; GRACE Charity, UK; Breast Cancer Campaign, UK; Michael Cuccione Childhood Cancer Foundation Postdoctoral Fellowship; Connecticut State University; Swedish Research Council; Swedish Research Society; University of Texas Health Science Centre at Tyler, Elsa U. Pardee Foundation; CPRIT; Cancer Prevention and Research Institute of Texas; NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH National Institute on Alcohol Abuse and Alcoholism (NIAAA); Gilead and Shire Pharmaceuticals; NIH/NCI [1R01CA20009, 5R01CAl27258-05, R21CA184788, NIH P30 CA22453, NCI RO1 28704]; Scottish Governments Rural and Environment Science and Analytical Services Divis

Published
2015
Full Text
View/download PDF

47. Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

Author

Feitelson, Mark A., primary, Arzumanyan, Alla, additional, Kulathinal, Rob J., additional, Blain, Stacy W., additional, Holcombe, Randall F., additional, Mahajna, Jamal, additional, Marino, Maria, additional, Martinez-Chantar, Maria L., additional, Nawroth, Roman, additional, Sanchez-Garcia, Isidro, additional, Sharma, Dipali, additional, Saxena, Neeraj K., additional, Singh, Neetu, additional, Vlachostergios, Panagiotis J., additional, Guo, Shanchun, additional, Honoki, Kanya, additional, Fujii, Hiromasa, additional, Georgakilas, Alexandros G., additional, Bilsland, Alan, additional, Amedei, Amedeo, additional, Niccolai, Elena, additional, Amin, Amr, additional, Ashraf, S. Salman, additional, Boosani, Chandra S., additional, Guha, Gunjan, additional, Ciriolo, Maria Rosa, additional, Aquilano, Katia, additional, Chen, Sophie, additional, Mohammed, Sulma I., additional, Azmi, Asfar S., additional, Bhakta, Dipita, additional, Halicka, Dorota, additional, Keith, W. Nicol, additional, and Nowsheen, Somaira, additional

Published
2015
Full Text
View/download PDF

48. The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint

Author

Castillo-Davis, Cristian I., Kondrashov, Fyodor A., Hartl, Daniel L., and Kulathinal, Rob J.

Subjects
Mammals -- Genetic aspects, Genomes -- Research, Nematoda -- Research, Genetic research, Health
Abstract

The functional spectrum of protein evolution in two separate animal phyla between mammalian and nematode lineages is studied. Observation showed the evidence of accelerated evolution among components of molecular systems involved in co evolutionary change in both phyla.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results