Search

Your search keyword '"Kulshreshtha, Dinesh K."' showing total 28 results
Start Over Author "Kulshreshtha, Dinesh K."
28 results on '"Kulshreshtha, Dinesh K."'

1. Streblus asper Lour. (Shakhotaka): A Review of its Chemical, Pharmacological and Ethnomedicinal Properties

Author

Rastogi, Subha, Kulshreshtha, Dinesh K., and Rawat, Ajay Kumar Singh

Subjects
Article Subject, parasitic diseases
Abstract

Streblus asper Lour is a small tree found in tropical countries, such as India, Sri Lanka, Malaysia, the Philippines and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as filariasis, leprosy, toothache, diarrhea, dysentery and cancer. Research carried out using different in vitro and in vivo techniques of biological evaluation support most of these claims. This review presents the botany, chemistry, traditional uses and pharmacology of this medicinal plant.

Published
2006
Full Text
View/download PDF

27. ChemInform Abstract: Bacoside A2— A Triterpenoid Saponin from Bacopa monniera.

Author

Rastogi, Subha and Kulshreshtha, Dinesh K.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Published
1999
Full Text
View/download PDF

28. Picroliv accelerates epithelialization and angiogenesis in rat wounds.

Author

Singh AK, Sharma A, Warren J, Madhavan S, Steele K, RajeshKumar NV, Thangapazham RL, Sharma SC, Kulshreshtha DK, Gaddipati J, and Maheshwari RK

Subjects
Administration, Oral, Angiogenesis Inducing Agents administration & dosage, Angiogenesis Inducing Agents therapeutic use, Animals, Aorta drug effects, Aorta pathology, Cinnamates administration & dosage, Cinnamates therapeutic use, Endothelium, Vascular drug effects, Endothelium, Vascular metabolism, Endothelium, Vascular physiology, Fibroblasts drug effects, Fibroblasts metabolism, Fibroblasts physiology, Glycosides administration & dosage, Glycosides therapeutic use, Humans, Male, Neovascularization, Physiologic physiology, Plant Extracts administration & dosage, Plant Extracts therapeutic use, Plant Roots, Rats, Rats, Sprague-Dawley, Umbilical Veins cytology, Vanillic Acid administration & dosage, Vanillic Acid therapeutic use, Vascular Endothelial Growth Factor A metabolism, Wound Healing physiology, Angiogenesis Inducing Agents pharmacology, Cinnamates pharmacology, Glycosides pharmacology, Phytotherapy, Picrorhiza, Plant Extracts pharmacology, Vanillic Acid pharmacology, Wound Healing drug effects
Abstract

Tissue repair and wound healing are complex processes that involve inflammation, granulation and tissue remodeling. Angiogenesis plays a central role in wound healing. Earlier, we have shown that picroliv, a natural product obtained from the roots of Picrorhiza kurrooa, up-regulates the expression of vascular endothelial growth factor in human umbilical vein endothelial cells and of insulin-like growth factor in rats during hypoxia. In the present study, we have investigated the effect of picroliv in an ex vivo rat aorta ring model of angiogenesis. Picroliv enhanced the sprouting and migration of endothelial cells. We also investigated punch wound healing on days 4 and 7 after wounding by histology, morphometry and collagenization. The data showed improved re-epithelialization, neovascularization and migration of various cells such as endothelial, dermal myofibroblasts and fibroblasts into the wound bed after picroliv treatment. Immunohistochemical localization showed increased VEGF and alpha smooth muscle actin staining consistent with an increased number of microvessels in granulation tissue. These findings suggest that picroliv could be developed as a therapeutic angiogenic agent for the restoration of the blood supply in diseases involving inadequate blood supply such as limb ischemia, ischemic myocardium and wound healing.

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results