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6. Iron Deposit Central Large Nodule in Alagille Syndrome

Author

Koma Y, Okuda T, Fujii T, Yokoi A, Ohtani A, Kumabe T, Kobayashi H, Nakashima O, Morisada N, Fujii Y, Nakai A, Hayakumo T, Kim Sk, and Kim

Subjects
Nodule (geology), Pathology, medicine.medical_specialty, business.industry, Alagille syndrome, medicine, engineering, General Medicine, engineering.material, medicine.disease, business
Published
2021

9. Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

Author

Nobre, L, Zapotocky, M, Khan, S, Fukuoka, K, Fonseca, A, McKeown, T, Sumerauer, D, Vicha, A, Grajkowska, WA, Trubicka, J, Li, KKW, Ng, H-K, Massimi, L, Lee, JY, Kim, S-K, Zelcer, S, Vasiljevic, A, Faure-Conter, C, Hauser, P, Lach, B, Van Veelen-Vincent, M-L, French, PJ, Van Meir, EG, Weiss, WA, Gupta, N, Pollack, IF, Hamilton, RL, Rao, AAN, Giannini, C, Rubin, JB, Moore, AS, Chambless, LB, Vibhakar, R, Ra, YS, Massimino, M, McLendon, RE, Wheeler, H, Zollo, M, Ferruci, V, Kumabe, T, Faria, CC, Sterba, J, Jung, S, Lopez-Aguilar, E, Mora, J, Carlotti, CG, Olson, JM, Leary, S, Cain, J, Krskova, L, Zamecnik, J, Hawkins, CE, Tabori, U, Huang, A, Bartels, U, Northcott, PA, Taylor, MD, Yip, S, Hansford, JR, Bouffet, E, Ramaswamy, V, Nobre, L, Zapotocky, M, Khan, S, Fukuoka, K, Fonseca, A, McKeown, T, Sumerauer, D, Vicha, A, Grajkowska, WA, Trubicka, J, Li, KKW, Ng, H-K, Massimi, L, Lee, JY, Kim, S-K, Zelcer, S, Vasiljevic, A, Faure-Conter, C, Hauser, P, Lach, B, Van Veelen-Vincent, M-L, French, PJ, Van Meir, EG, Weiss, WA, Gupta, N, Pollack, IF, Hamilton, RL, Rao, AAN, Giannini, C, Rubin, JB, Moore, AS, Chambless, LB, Vibhakar, R, Ra, YS, Massimino, M, McLendon, RE, Wheeler, H, Zollo, M, Ferruci, V, Kumabe, T, Faria, CC, Sterba, J, Jung, S, Lopez-Aguilar, E, Mora, J, Carlotti, CG, Olson, JM, Leary, S, Cain, J, Krskova, L, Zamecnik, J, Hawkins, CE, Tabori, U, Huang, A, Bartels, U, Northcott, PA, Taylor, MD, Yip, S, Hansford, JR, Bouffet, E, and Ramaswamy, V

Abstract

Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse. To address this gap in knowledge, an international cohort of 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763-0.925) with 15 relapsed individuals identified. Maintenance chemotherapy is identified as a strong predictor of relapse, with individuals receiving high doses of cyclophosphamide or ifosphamide having only one very late molecularly confirmed relapse (p = 0.032). The anatomical location of recurrence is metastatic in 12 of 15 relapses, with 8 of 12 metastatic relapses in the lateral ventricles. Maintenance chemotherapy, specifically cumulative cyclophosphamide doses, is a significant predictor of relapse across WNT MB. Future efforts to de-escalate therapy need to carefully consider not only the radiation dose but also the chemotherapy regimen and the propensity for metastatic relapses.

Published
2020

10. Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort

Author

de Medeiros, CB, Moxon-Emre, I, Scantlebury, N, Malkin, D, Ramaswamy, V, Decker, A, Law, N, Kumabe, T, Leonard, J, Rubin, J, Jung, S, Kim, SK, Gupta, N, Weiss, W, Faria, CC, Vibhakar, R, Lafay-Cousin, L, Chan, J, Kros, J.M., Janzen, L, Taylor, MD, Bouffet, E, Mabbott, DJ, de Medeiros, CB, Moxon-Emre, I, Scantlebury, N, Malkin, D, Ramaswamy, V, Decker, A, Law, N, Kumabe, T, Leonard, J, Rubin, J, Jung, S, Kim, SK, Gupta, N, Weiss, W, Faria, CC, Vibhakar, R, Lafay-Cousin, L, Chan, J, Kros, J.M., Janzen, L, Taylor, MD, Bouffet, E, and Mabbott, DJ

Published
2020

24. The impact of continuing ALK inhibitors beyond initial disease progression on clinical outcome in patients with advanced ALK-positive non-small cell lung cancer: Results of a multicenter retrospective analysis

Author

Sakata, S., primary, Saeki, S., additional, Sakata, Y., additional, Kawamura, K., additional, Ichikado, K., additional, Inaba, M., additional, Ushijima, S., additional, Imamura, K., additional, Iyonaga, K., additional, Kumabe, T., additional, Fujita, R., additional, Kashiwabara, K., additional, Fujii, S., additional, Komatsu, T., additional, Sakamoto, O., additional, Okabayashi, H., additional, Saruwatari, K., additional, Tomita, Y., additional, and Sakagami, T., additional

Published
2018
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25. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Author

Thompson, EM, Hielscher, T, Bouffet, E, Remke, M, Luu, B, Gururangan, S, McLendon, RE, Bigner, DD, Lipp, ES, Perreault, S, Cho, YJ, Grant, G, Kim, SK, Lee, JY, Rao, AAN, Giannini, C, Li, KKW, Ng, HK, Yao, Y, Kumabe, T, Tominaga, T, Grajkowska, WA, Perek-Polnik, M, Low, DCY, Seow, WT, Chang, KTE, Mora, J, Pollack, IF, Hamilton, RL, Leary, S, Moore, AS, Ingram, WJ, Hallahan, AR, Jouvet, A, Fèvre-Montange, M, Vasiljevic, A, Faure-Conter, C, Shofuda, T, Kagawa, N, Hashimoto, N, Jabado, N, Weil, AG, Gayden, T, Wataya, T, Shalaby, T, Grotzer, M, Zitterbart, K, Sterba, J, Kren, L, Hortobágyi, T, Klekner, A, László, B, Pócza, T, Hauser, P, Schüller, U, Jung, S, Jang, WY, French, PJ, Kros, JM, van Veelen, MLC, Massimi, L, Leonard, JR, Rubin, JB, Vibhakar, R, Chambless, LB, Cooper, MK, Thompson, RC, Faria, CC, Carvalho, A, Nunes, S, Pimentel, J, Fan, X, Muraszko, KM, López-Aguilar, E, Lyden, D, Garzia, L, Shih, DJH, Kijima, N, Schneider, C, Adamski, J, Northcott, PA, Kool, M, Jones, DTW, Chan, JA, Nikolic, A, Garre, ML, Van Meir, EG, Osuka, S, Olson, JJ, Jahangiri, A, and Castro, BA

Subjects
Adult, Male, Canada, Brain Neoplasms, Infant, Prognosis, Magnetic Resonance Imaging, Combined Modality Therapy, Disease-Free Survival, Child, Preschool, Disease Progression, Humans, Female, Child, Medulloblastoma, Retrospective Studies
Abstract

© 2016 Elsevier Ltd Background Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner. Methods We retrospectively identified patients who had a histological diagnosis of medulloblastoma and complete data about extent of resection and survival from centres participating in the Medulloblastoma Advanced Genomics International Consortium. We collected from resections done between April, 1997, and February, 2013, at 35 international institutions. We established medulloblastoma subgroup affiliation by gene expression profiling on frozen or formalin-fixed paraffin-embedded tissues. We classified extent of resection on the basis of postoperative imaging as gross total resection (no residual tumour), near-total resection (30 Gy vs no craniospinal irradiation). The primary analysis outcome was the effect of extent of resection by molecular subgroup and the effects of other clinical variables on overall and progression-free survival. Findings We included 787 patients with medulloblastoma (86 with WNT tumours, 242 with SHH tumours, 163 with group 3 tumours, and 296 with group 4 tumours) in our multivariable Cox models of progression-free and overall survival. We found that the prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. We identified a progression-free survival benefit for gross total resection over sub-total resection (hazard ratio [HR] 1·45, 95% CI 1·07–1·96, p=0·16) but no overall survival benefit (HR 1·23, 0·87–1·72, p=0·24). We saw no progression-free survival or overall survival benefit for gross total resection compared with near-total resection (HR 1·05, 0·71–1·53, p=0·8158 for progression-free survival and HR 1·14, 0·75–1·72, p=0·55 for overall survival). No significant survival benefit existed for greater extent of resection for patients with WNT, SHH, or group 3 tumours (HR 1·03, 0·67–1·58, p=0·89 for sub-total resection vs gross total resection). For patients with group 4 tumours, gross total resection conferred a benefit to progression-free survival compared with sub-total resection (HR 1·97, 1·22–3·17, p=0·0056), especially for those with metastatic disease (HR 2·22, 1·00–4·93, p=0·050). However, gross total resection had no effect on overall survival compared with sub-total resection in patients with group 4 tumours (HR 1·67, 0·93–2·99, p=0·084). Interpretation The prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. Although maximum safe surgical resection should remain the standard of care, surgical removal of small residual portions of medulloblastoma is not recommended when the likelihood of neurological morbidity is high because there is no definitive benefit to gross total resection compared with near-total resection. Funding Canadian Cancer Society Research Institute, Terry Fox Research Institute, Canadian Institutes of Health Research, National Institutes of Health, Pediatric Brain Tumor Foundation, and the Garron Family Chair in Childhood Cancer Research.

Published
2016

30. Pulsed laser-induced liquid jet: evolution from shock/bubble interaction to neurosurgical application

Author

Nakagawa, A., primary, Kumabe, T., additional, Ogawa, Y., additional, Hirano, T., additional, Kawaguchi, T., additional, Ohtani, K., additional, Nakano, T., additional, Sato, C., additional, Yamada, M., additional, Washio, T., additional, Arafune, T., additional, Teppei, T., additional, Atsushi, K., additional, Satomi, S., additional, Takayama, K., additional, and Tominaga, T., additional

Published
2016
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31. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: A retrospective integrated clinical and molecular analysis

Author

Thompson, E.M. (Eric M.), Hielscher, T. (Thomas), Bouffet, E. (Eric), Remke, M. (Marc), Luu, P. (Phan), Gururangan, S. (Sridharan), McLendon, R.E. (Roger E.), Bigner, D.D. (Darell), Lipp, E.S. (Eric S.), Perreault, S. (Sebastien), Cho, Y.-J. (Yoon-Jae), Grant, G. (Gerald), Kim, S.-K. (Seung-Ki), Lee, J.Y. (Ji Yeoun), Rao, A.A.N. (Amulya A. Nageswara), Giannini, C. (Caterina), Li, K.K.W. (Kay Ka Wai), Ng, H.-K. (Ho-Keung), Yao, Y. (Yu), Kumabe, T. (Toshihiro), Tominaga, T. (Teiji), Grajkowska, W.A. (Wieslawa), Perek-Polnik, M. (Marta), Low, D.C.Y. (David C.Y.), Seow, W.T. (Wan Tew), Chang, K.T.E. (Kenneth T.E.), Mora, J. (Jaume), Pollack, A. (Aaron), Hamilton, R.L. (Ronald L.), Leary, S. (Sarah), Moore, A.S. (Andrew S.), Ingram, W.J. (Wendy J.), Hallahan, A.R. (Andrew R.), Jouvet, A. (Anne), Fèvre-Montange, M. (Michelle), Vasiljevic, A. (Alexandre), Faure-Conter, C. (Cecile), Shofuda, T. (Tomoko), Kagawa, N. (Naoki), Hashimoto, N. (Naoya), Jabado, N. (Nada), Weil, A.G. (Alexander G.), Gayden, T. (Tenzin), Wataya, T. (Takafumi), Shalaby, T. (Tarek), Grotzer, M. (Michael), Zitterbart, K. (Karel), Sterba, J., Kren, L. (Leos), Hortobágyi, T. (Tibor), Klekner, A. (Almos), Bognár, L. (László), Pócza, T. (Tímea), Hauser, P. (Peter), Schüller, U. (Ulrich), Jung, S. (Shin), Jang, W.-Y. (Woo-Youl), French, P.J. (Pim), Kros, J.M. (Johan), Veelen-Vincent, M.L.C. (Marie-Lise) van, Massimi, L. (Luca), Leonard, J.R. (Jeffrey), Rubin, J.B. (Joshua), Vibhakar, R. (Rajeev), Chambless, L.B. (Lola B.), Cooper, M.K. (Michael), Thompson, R.C. (Reid), Faria, R. (Rui), Carvalho, A. (Alice), Nunes, S. (Sofia), Pimentel, J., Fan, X. (Xing), Muraszko, K.M. (Karin), López-Aguilar, E. (Enrique), Lyden, D. (David), Garzia, L. (Livia), Shih, D.J.H. (David J.), Kijima, N. (Noriyuki), Schneider, C. (Christian), Adamski, J. (Jennifer), Northcott, P.A. (Paul A.), Kool, M. (Marcel), Jones, D. (David), Chan, J.A. (Jennifer A.), Nikolic, A. (Ana), Garre, M.L. (Maria Luisa), Van Meir, E.G. (Erwin G.), Osuka, S. (Satoru), Olson, J.J. (Jeffrey J.), Jahangiri, A. (Arman), Castro, B.A. (Brandyn A.), Gupta, N. (Nalin), Weiss, W.A. (William A.), Moxon-Emre, I. (Iska), Mabbott, D.J. (Donald J.), Lassaletta, A. (Alvaro), Hawkins, C.E. (Cynthia), Tabori, U. (Uri), Drake, J. (James), Kulkarni, A. (Abhaya), Dirks, M. (Maaike), Rutka, J.T. (James), Korshunov, A. (Andrey), Pfister, S.M. (Stefan), Packer, R.J. (Roger J.), Ramaswamy, E.A., Taylor, M.D. (Michael), Thompson, E.M. (Eric M.), Hielscher, T. (Thomas), Bouffet, E. (Eric), Remke, M. (Marc), Luu, P. (Phan), Gururangan, S. (Sridharan), McLendon, R.E. (Roger E.), Bigner, D.D. (Darell), Lipp, E.S. (Eric S.), Perreault, S. (Sebastien), Cho, Y.-J. (Yoon-Jae), Grant, G. (Gerald), Kim, S.-K. (Seung-Ki), Lee, J.Y. (Ji Yeoun), Rao, A.A.N. (Amulya A. Nageswara), Giannini, C. (Caterina), Li, K.K.W. (Kay Ka Wai), Ng, H.-K. (Ho-Keung), Yao, Y. (Yu), Kumabe, T. (Toshihiro), Tominaga, T. (Teiji), Grajkowska, W.A. (Wieslawa), Perek-Polnik, M. (Marta), Low, D.C.Y. (David C.Y.), Seow, W.T. (Wan Tew), Chang, K.T.E. (Kenneth T.E.), Mora, J. (Jaume), Pollack, A. (Aaron), Hamilton, R.L. (Ronald L.), Leary, S. (Sarah), Moore, A.S. (Andrew S.), Ingram, W.J. (Wendy J.), Hallahan, A.R. (Andrew R.), Jouvet, A. (Anne), Fèvre-Montange, M. (Michelle), Vasiljevic, A. (Alexandre), Faure-Conter, C. (Cecile), Shofuda, T. (Tomoko), Kagawa, N. (Naoki), Hashimoto, N. (Naoya), Jabado, N. (Nada), Weil, A.G. (Alexander G.), Gayden, T. (Tenzin), Wataya, T. (Takafumi), Shalaby, T. (Tarek), Grotzer, M. (Michael), Zitterbart, K. (Karel), Sterba, J., Kren, L. (Leos), Hortobágyi, T. (Tibor), Klekner, A. (Almos), Bognár, L. (László), Pócza, T. (Tímea), Hauser, P. (Peter), Schüller, U. (Ulrich), Jung, S. (Shin), Jang, W.-Y. (Woo-Youl), French, P.J. (Pim), Kros, J.M. (Johan), Veelen-Vincent, M.L.C. (Marie-Lise) van, Massimi, L. (Luca), Leonard, J.R. (Jeffrey), Rubin, J.B. (Joshua), Vibhakar, R. (Rajeev), Chambless, L.B. (Lola B.), Cooper, M.K. (Michael), Thompson, R.C. (Reid), Faria, R. (Rui), Carvalho, A. (Alice), Nunes, S. (Sofia), Pimentel, J., Fan, X. (Xing), Muraszko, K.M. (Karin), López-Aguilar, E. (Enrique), Lyden, D. (David), Garzia, L. (Livia), Shih, D.J.H. (David J.), Kijima, N. (Noriyuki), Schneider, C. (Christian), Adamski, J. (Jennifer), Northcott, P.A. (Paul A.), Kool, M. (Marcel), Jones, D. (David), Chan, J.A. (Jennifer A.), Nikolic, A. (Ana), Garre, M.L. (Maria Luisa), Van Meir, E.G. (Erwin G.), Osuka, S. (Satoru), Olson, J.J. (Jeffrey J.), Jahangiri, A. (Arman), Castro, B.A. (Brandyn A.), Gupta, N. (Nalin), Weiss, W.A. (William A.), Moxon-Emre, I. (Iska), Mabbott, D.J. (Donald J.), Lassaletta, A. (Alvaro), Hawkins, C.E. (Cynthia), Tabori, U. (Uri), Drake, J. (James), Kulkarni, A. (Abhaya), Dirks, M. (Maaike), Rutka, J.T. (James), Korshunov, A. (Andrey), Pfister, S.M. (Stefan), Packer, R.J. (Roger J.), Ramaswamy, E.A., and Taylor, M.D. (Michael)

Abstract

Background: Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner. Methods: We retrospectively identified patients who had a histological diagnosis of medulloblastoma and complete data about extent of resection and survival from centres participating in the Medulloblastoma Advanced Genomics International Consortium. We collected from resections done between April, 1997, and February, 2013, at 35 international institutions. We established medulloblastoma subgroup affiliation by gene expression profiling on frozen or formalin-fixed paraffin-embedded tissues. We classified extent of resection on the basis of postoperative imaging as gross total resection (no residual tumour), near-total resection (<1·5 cm2 tumour remaining), or sub-total resection (≥1·5 cm2 tumour remaining). We did multivariable analyses of overall survival and progression-free survival using the variables molecular subgroup (WNT, SHH, group 4, and group 3), age (<3 vs ≥3 years old), metastatic status (metastases vs no metastases), geographical location of therapy (North America/Australia vs rest of the world), receipt of chemotherapy (yes vs no) and receipt of craniospinal irradiation (<30 Gy or >30 Gy vs no craniospinal irradiation). The primary analysis outcome was the effect of extent of resection by molecular subgroup and the effects of other clinical variables on overall and progression-free survival. Findings: We included 787 patients with medulloblastoma (86 with WNT tumours, 242 with SHH tumours, 163 with group 3 tumours, and 296 with group 4 tumours) in our multivariable Cox mod

Published
2016
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32. Cytogenetic prognostication within medulloblastoma subgroups

Author

Shih, DJH, Northcott, PA, Remke, M, Korshunov, A, Ramaswamy, V, Kool, M, Luu, B, Yao, Y, Wang, X, Dubuc, AM, Garzia, L, Peacock, J, Mack, SC, Wu, X, Rolider, A, Morrissy, AS, Cavalli, FMG, Jones, DTW, Zitterbart, K, Faria, CC, Schüller, U, Kren, L, Kumabe, T, Tominaga, T, Ra, YS, Garami, M, Hauser, P, Chan, JA, Robinson, S, Bognár, L, Klekner, A, Saad, AG, Liau, LM, Albrecht, S, Fontebasso, A, Cinalli, G, De Antonellis, P, Zollo, M, Cooper, MK, Thompson, RC, Bailey, S, Lindsey, JC, Di Rocco, C, Massimi, L, Michiels, EMC, Scherer, SW, Phillips, JJ, Gupta, N, Fan, X, Muraszko, KM, Vibhakar, R, Eberhart, CG, Fouladi, M, Lach, B, Jung, S, Wechsler-Reya, RJ, Fèvre-Montange, M, Jouvet, A, Jabado, N, Pollack, IF, Weiss, WA, Lee, JY, Cho, BK, Kim, SK, Wang, KC, Leonard, JR, Rubin, JB, De Torres, C, Lavarino, C, Mora, J, Cho, YJ, Tabori, U, Olson, JM, Gajjar, A, Packer, RJ, Rutkowski, S, Pomeroy, SL, French, PJ, Kloosterhof, NK, Kros, JM, Van Meir, EG, Clifford, SC, Bourdeaut, F, Delattre, O, Doz, FF, Hawkins, CE, Malkin, D, and Grajkowska, WA

Subjects
Male, Adolescent, Kruppel-Like Transcription Factors, Zinc Finger Protein Gli2, Risk Assessment, Proto-Oncogene Proteins c-myc, Cytogenetics, Young Adult, Risk Factors, Predictive Value of Tests, Biomarkers, Tumor, Humans, Hedgehog Proteins, Oncology & Carcinogenesis, Child, In Situ Hybridization, Fluorescence, Proportional Hazards Models, Chromosomes, Human, Pair 14, Oncology And Carcinogenesis, Chromosomes, Human, Pair 11, Gene Expression Profiling, Nuclear Proteins, Reproducibility of Results, Infant, Prognosis, Gene Expression Regulation, Neoplastic, Wnt Proteins, Tissue Array Analysis, Child, Preschool, Female, Medulloblastoma
Abstract

Purpose: Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication. Patients and Methods: Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent in situ hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models. Results: Subgroup information improves the predictive accuracy of a multivariable survival model compared with clinical biomarkers alone. Most previously published cytogenetic biomarkers are only prognostic within a single medulloblastoma subgroup. Profiling six FISH biomarkers (GLI2, MYC, chromosome 11 [chr11], chr14, 17p, and 17q) on formalin-fixed paraffin-embedded tissues, we can reliably and reproducibly identify very low-risk and very high-risk patients within SHH, Group 3, and Group 4 medulloblastomas. Conclusion: Combining subgroup and cytogenetic biomarkers with established clinical biomarkers substantially improves patient prognostication, even in the context of heterogeneous clinical therapies. The prognostic significance of most molecular biomarkers is restricted to a specific subgroup. We have identified a small panel of cytogenetic biomarkers that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials. © 2014 by American Society of Clinical Oncology.

Published
2014

33. 528P - The impact of continuing ALK inhibitors beyond initial disease progression on clinical outcome in patients with advanced ALK-positive non-small cell lung cancer: Results of a multicenter retrospective analysis

Author

Sakata, S., Saeki, S., Sakata, Y., Kawamura, K., Ichikado, K., Inaba, M., Ushijima, S., Imamura, K., Iyonaga, K., Kumabe, T., Fujita, R., Kashiwabara, K., Fujii, S., Komatsu, T., Sakamoto, O., Okabayashi, H., Saruwatari, K., Tomita, Y., and Sakagami, T.

Published
2018
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36. WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

Author

Zhukova, N, Ramaswamy, V, Remke, M, Martin, DC, Castelo-Branco, P, Zhang, CH, Fraser, M, Tse, K, Poon, R, Shih, DJH, Baskin, B, Ray, PN, Bouffet, E, Dirks, P, von Bueren, AO, Pfaff, E, Korshunov, A, Jones, DTW, Northcott, PA, Kool, M, Pugh, TJ, Pomeroy, SL, Cho, YJ, Pietsch, T, Gessi, M, Rutkowski, S, Bognár, L, Cho, BK, Eberhart, CG, Conter, CF, Fouladi, M, French, PJ, Grajkowska, WA, Gupta, N, Hauser, P, Jabado, N, Vasiljevic, A, Jung, S, Kim, SK, Klekner, A, Kumabe, T, Lach, B, Leonard, JR, Liau, LM, Massimi, L, Pollack, IF, Ra, YS, Rubin, JB, Van Meir, EG, Wang, KC, Weiss, WA, Zitterbart, K, Bristow, RG, Alman, B, Hawkins, CE, Malkin, D, Clifford, SC, Pfister, SM, Taylor, MD, Tabori, U, Zhukova, N, Ramaswamy, V, Remke, M, Martin, DC, Castelo-Branco, P, Zhang, CH, Fraser, M, Tse, K, Poon, R, Shih, DJH, Baskin, B, Ray, PN, Bouffet, E, Dirks, P, von Bueren, AO, Pfaff, E, Korshunov, A, Jones, DTW, Northcott, PA, Kool, M, Pugh, TJ, Pomeroy, SL, Cho, YJ, Pietsch, T, Gessi, M, Rutkowski, S, Bognár, L, Cho, BK, Eberhart, CG, Conter, CF, Fouladi, M, French, PJ, Grajkowska, WA, Gupta, N, Hauser, P, Jabado, N, Vasiljevic, A, Jung, S, Kim, SK, Klekner, A, Kumabe, T, Lach, B, Leonard, JR, Liau, LM, Massimi, L, Pollack, IF, Ra, YS, Rubin, JB, Van Meir, EG, Wang, KC, Weiss, WA, Zitterbart, K, Bristow, RG, Alman, B, Hawkins, CE, Malkin, D, Clifford, SC, Pfister, SM, Taylor, MD, and Tabori, U

Abstract

TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or mutant human medulloblastoma cell-lines and normal neural stem cells were used to test radioresistance of TP53 mutations and the radiosensitizing effect of WNT activation on tumors and the developing brain. Children with WNT/TP53 mutant medulloblastoma had higher 5-year survival than those with SHH/TP53 mutant tumours (100% and 36.6% ± 8.7%, respectively (p < 0.001)). Introduction of TP53 mutation into medulloblastoma cells induced radioresistance (survival fractions at 2Gy (SF2) of 89% ± 2% vs. 57.4% ± 1.8% (p < 0.01)). In contrast, β-catenin mutation sensitized TP53 mutant cells to radiation (p < 0.05). Lithium, an activator of the WNT pathway, sensitized TP53 mutant medulloblastoma to radiation (SF2 of 43.5% ± 1.5% in lithium treated cells vs. 56.6 ± 3% (p < 0.01)) accompanied by increased number of γH2AX foci. Normal neural stem cells were protected from lithium induced radiation damage (SF2 of 33% ± 8% for lithium treated cells vs. 27% ± 3% for untreated controls (p = 0.05). Poor survival of patients with TP53 mutant medulloblastoma may be related to radiation resistance. Since constitutive activation of the WNT pathway by lithium sensitizes TP53 mutant medulloblastoma cells and protect normal neural stem cells from radiation, this oral drug may represent an attractive novel therapy for high-risk medulloblastomas.

Published
2014

38. NEUROPSYCHOLOGY

Author

Boman, K. K., primary, Hornquist, L., additional, Rickardsson, J., additional, Lannering, B., additional, Gustafsson, G., additional, Pitchford, N., additional, Davis, E., additional, Walker, D., additional, Hoang, D. H., additional, Pagnier, A., additional, Cousin, E., additional, Guichardet, K., additional, Schiff, I., additional, Dubois-Teklali, F., additional, Krainik, A., additional, Lazar, M. B., additional, Resnik, K., additional, Olsson, I. T., additional, Perrin, S., additional, Burtscher, I. B., additional, Lundgren, J., additional, Kahn, A., additional, Johanson, A., additional, Korzeniewska, J., additional, Dembowska-Baginska, B., additional, Perek-Polnik, M., additional, Walsh, K., additional, Gioia, A., additional, Wells, E., additional, Packer, R., additional, de Speville, E. D., additional, Dufour, C., additional, Bolle, S., additional, Giraudat, K., additional, Longaud, A., additional, Kieffer, V., additional, Grill, J., additional, Puget, S., additional, Valteau-Couanet, D., additional, Hetz-Pannier, L., additional, Noulhiane, M., additional, Chieffo, D., additional, Tamburrini, G., additional, Caldarelli, M., additional, Di Rocco, C., additional, Margelisch, K., additional, Studer, M., additional, Steinlin, M., additional, Leibundgut, K., additional, Heinks, T., additional, Longaud-Vales, A., additional, Chevignard, M., additional, Pujet, S., additional, Sainte-Rose, C., additional, Dellatolas, G., additional, Kahalley, L., additional, Grosshans, D., additional, Paulino, A., additional, Ris, M. D., additional, Chintagumpala, M., additional, Okcu, F., additional, Moore, B., additional, Stancel, H., additional, Minard, C., additional, Guffey, D., additional, Mahajan, A., additional, Herrington, B., additional, Raiker, J., additional, Manning, E., additional, Criddle, J., additional, Karlson, C., additional, Guerry, W., additional, Finlay, J., additional, Sands, S., additional, Dockstader, C., additional, Skocic, J., additional, Bouffet, E., additional, Laughlin, S., additional, Tabori, U., additional, Mabbott, D., additional, Moxon-Emre, I., additional, Scantlebury, N., additional, Taylor, M. D., additional, Malkin, D., additional, Law, N., additional, Kumabe, T., additional, Leonard, J., additional, Rubin, J., additional, Jung, S., additional, Kim, S.-K., additional, Gupta, N., additional, Weiss, W., additional, Faria, C., additional, Vibhakar, R., additional, Spiegler, B., additional, Janzen, L., additional, Liu, F., additional, Decker, L., additional, Lemiere, J., additional, Vercruysse, T., additional, Haers, M., additional, Vandenabeele, K., additional, Geuens, S., additional, Jacobs, S., additional, Van Gool, S., additional, Riggs, L., additional, Piscione, J., additional, Timmons, B., additional, Cunningham, T., additional, Bartels, U., additional, Chakravarty, M., additional, Laperriere, N., additional, Pipitone, J., additional, Strother, D., additional, Hukin, J., additional, Fryer, C., additional, McConnell, D., additional, Secco, D. E., additional, Cappelletti, S., additional, Gentile, S., additional, Cacchione, A., additional, Del Bufalo, F., additional, Staccioli, S., additional, Spagnoli, A., additional, Messina, R., additional, Carai, A., additional, Marras, C. E., additional, Mastronuzzi, A., additional, Brinkman, T., additional, Armstrong, G., additional, Kimberg, C., additional, Gajjar, A., additional, Srivastava, D. K., additional, Robison, L., additional, Hudson, M., additional, Krull, K., additional, Hardy, K., additional, Hostetter, S., additional, Hwang, E., additional, Leiss, U., additional, Bemmer, A., additional, Pletschko, T., additional, Grafeneder, J., additional, Schwarzinger, A., additional, Deimann, P., additional, Slavc, I., additional, Batchelder, P., additional, Wilkening, G., additional, Hankinson, T., additional, Foreman, N., additional, and Handler, M., additional

Published
2014
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39. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Author

Remke, M. (Marc), Ramaswamy, E.A., Peacock, M. (Munro), Shih, D.J.H. (David J.), Koelsche, C. (Christian), Northcott, P.A. (Paul A.), Hill, N. (Nadia), Cavalli, S. (Silvia), Kool, M. (Marcel), Wang, X. (Xin), Mack, S. (Stephen), Barszczyk, M. (Mark), Morrissy, A.S. (A. Sorana), Wu, X. (Xiaochong), Agnihotri, S. (Sameer), Luu, P. (Phan), Jones, D. (David), Garzia, L. (Livia), Dubuc, A.M. (Adrian), Zhukova, N. (Nataliya), Vanner, R. (Robert), Kros, J.M. (Johan), French, P.J. (Pim), Meir, E.G. (Erwin) van, Vibhakar, R. (Rajeev), Zitterbart, K. (Karel), Chan, J.A. (Jennifer), Bognár, L. (László), Klekner, A. (Almos), Lach, B. (Boleslaw), Jung, S. (Shin), Saad, F. (Fred), Liau, L.M. (Linda), Albrecht, S. (Steffen), Zollo, M. (Maurizio), Cooper, M.K. (Michael), Thompson, R.C. (Reid), Delattre, O. (Olivier), Bourdeaut, F. (Franck), Doz, F.F. (François), Garami, M. (Miklós), Hauser, P. (Peter), Carlotti, C.G. (Carlos), Van Meter, T.E. (Timothy), Massimi, L. (Luca), Fults, D. (Daniel), Pomeroy, L.W. (Laura), Kumabe, T. (Toshiro), Ra, Y.S. (Young Shin), Leonard, J.R. (Jeffrey), Elbabaa, S.K. (Samer), Mora, J. (Jaume), Rubin, J.B. (Joshua), Cho, Y.-J. (Yoon-Jae), McLendon, R.E. (Roger), Bigner, D.D. (Darell), Eberhart, C.G. (Charles), Fouladi, M. (Maryam), Wechsler-Reya, R.J. (Robert), Faria, R. (Rui), Croul, S.E. (Sidney), Huang, A. (Anding), Bouffet, E. (Eric), Hawkins, C.E. (Cynthia), Dirks, M. (Maaike), Weiss, W.A. (William), Schüller, U. (Ulrich), Pollack, A. (Aaron), Rutkowski, P. (Piotr), Meyronet, D. (David), Jouvet, A. (Anne), Fèvre-Montange, M. (Michelle), Jabado, N. (Nada), Perek-Polnik, M. (Marta), Grajkowska, W.A. (Wieslawa), Kim, S.-K. (Seung-Ki), Rutka, J.T. (James), Malkin, E. (Elissa), Tabori, U. (Uri), Pfister, S.M. (Stefan), Korshunov, A. (Andrey), Deimling, A. (Andreas) von, Taylor, M.D. (Michael), Remke, M. (Marc), Ramaswamy, E.A., Peacock, M. (Munro), Shih, D.J.H. (David J.), Koelsche, C. (Christian), Northcott, P.A. (Paul A.), Hill, N. (Nadia), Cavalli, S. (Silvia), Kool, M. (Marcel), Wang, X. (Xin), Mack, S. (Stephen), Barszczyk, M. (Mark), Morrissy, A.S. (A. Sorana), Wu, X. (Xiaochong), Agnihotri, S. (Sameer), Luu, P. (Phan), Jones, D. (David), Garzia, L. (Livia), Dubuc, A.M. (Adrian), Zhukova, N. (Nataliya), Vanner, R. (Robert), Kros, J.M. (Johan), French, P.J. (Pim), Meir, E.G. (Erwin) van, Vibhakar, R. (Rajeev), Zitterbart, K. (Karel), Chan, J.A. (Jennifer), Bognár, L. (László), Klekner, A. (Almos), Lach, B. (Boleslaw), Jung, S. (Shin), Saad, F. (Fred), Liau, L.M. (Linda), Albrecht, S. (Steffen), Zollo, M. (Maurizio), Cooper, M.K. (Michael), Thompson, R.C. (Reid), Delattre, O. (Olivier), Bourdeaut, F. (Franck), Doz, F.F. (François), Garami, M. (Miklós), Hauser, P. (Peter), Carlotti, C.G. (Carlos), Van Meter, T.E. (Timothy), Massimi, L. (Luca), Fults, D. (Daniel), Pomeroy, L.W. (Laura), Kumabe, T. (Toshiro), Ra, Y.S. (Young Shin), Leonard, J.R. (Jeffrey), Elbabaa, S.K. (Samer), Mora, J. (Jaume), Rubin, J.B. (Joshua), Cho, Y.-J. (Yoon-Jae), McLendon, R.E. (Roger), Bigner, D.D. (Darell), Eberhart, C.G. (Charles), Fouladi, M. (Maryam), Wechsler-Reya, R.J. (Robert), Faria, R. (Rui), Croul, S.E. (Sidney), Huang, A. (Anding), Bouffet, E. (Eric), Hawkins, C.E. (Cynthia), Dirks, M. (Maaike), Weiss, W.A. (William), Schüller, U. (Ulrich), Pollack, A. (Aaron), Rutkowski, P. (Piotr), Meyronet, D. (David), Jouvet, A. (Anne), Fèvre-Montange, M. (Michelle), Jabado, N. (Nada), Perek-Polnik, M. (Marta), Grajkowska, W.A. (Wieslawa), Kim, S.-K. (Seung-Ki), Rutka, J.T. (James), Malkin, E. (Elissa), Tabori, U. (Uri), Pfister, S.M. (Stefan), Korshunov, A. (Andrey), Deimling, A. (Andreas) von, and Taylor, M.D. (Michael)

Abstract

Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were determined according to subgroup affiliation, demographics, and clinical, prognostic, and molecular features. Integrated genomics approaches were used to identify specific somatic copy number alterations in TERT promoter-mutated and wild-type tumors. Overall, TERT promoter mutations were identified in 21 % of medulloblastomas. Strikingly, the highest frequencies of TERT mutations were observed in SHH (83 %; 55/66) and WNT (31 %; 4/13) medulloblastomas derived from adult patients. Group 3 and Group 4 harbored this alteration in <5 % of cases and showed no association with

Published
2013
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40. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Author

Remke, M, Ramaswamy, V, Peacock, J, Shih, DJH, Koelsche, C, Northcott, PA, Hill, N, Cavalli, FMG, Kool, Mirjam, Wang, X, Mack, SC, Barszczyk, M, Morrissy, AS, Wu, XC, Agnihotri, S, Luu, B, Jones, DTW, Garzia, L, Dubuc, AM, Zhukova, N, Vanner, R, Kros, J.M., French, Pim, van Meir, EG, Vibhakar, R, Zitterbart, K, Chan, JA, Bognar, L, Klekner, A, Lach, B, Jung, S, Saad, AG, Albrecht, S, Liau, LM, Zollo, M, Cooper, MK, Thompson, RC, Delattre, OO, Bourdeaut, F, Doz, FF, Garami, M, Hauser, P, Carlotti, CG, Van Meter, TE, Massimi, L, Fults, D, Pomeroy, SL, Kumabe, T, Ra, YS, Leonard, JR, Elbabaa, SK, Mora, J, Rubin, JB, Cho, YJ, McLendon, RE, Bigner, DD, Eberhart, CG, Fouladi, M, Wechsler-Reya, RJ, Faria, CC, Croul, SE, Huang, A, Bouffet, E, Hawkins, CE, Dirks, PB, Weiss, WA, Schuller, U, Pollack, IF, Rutkowski, S, Meyronet, D, Jouvet, A, Fevre-Montange, M, Jabado, N, Perek-Polnik, M, Grajkowska, WA, Kim, SK, Rutka, JT, Malkin, D, Tabori, U, Pfister, SM, Korshunov, A, von Deimling, A, Taylor, MD, Remke, M, Ramaswamy, V, Peacock, J, Shih, DJH, Koelsche, C, Northcott, PA, Hill, N, Cavalli, FMG, Kool, Mirjam, Wang, X, Mack, SC, Barszczyk, M, Morrissy, AS, Wu, XC, Agnihotri, S, Luu, B, Jones, DTW, Garzia, L, Dubuc, AM, Zhukova, N, Vanner, R, Kros, J.M., French, Pim, van Meir, EG, Vibhakar, R, Zitterbart, K, Chan, JA, Bognar, L, Klekner, A, Lach, B, Jung, S, Saad, AG, Albrecht, S, Liau, LM, Zollo, M, Cooper, MK, Thompson, RC, Delattre, OO, Bourdeaut, F, Doz, FF, Garami, M, Hauser, P, Carlotti, CG, Van Meter, TE, Massimi, L, Fults, D, Pomeroy, SL, Kumabe, T, Ra, YS, Leonard, JR, Elbabaa, SK, Mora, J, Rubin, JB, Cho, YJ, McLendon, RE, Bigner, DD, Eberhart, CG, Fouladi, M, Wechsler-Reya, RJ, Faria, CC, Croul, SE, Huang, A, Bouffet, E, Hawkins, CE, Dirks, PB, Weiss, WA, Schuller, U, Pollack, IF, Rutkowski, S, Meyronet, D, Jouvet, A, Fevre-Montange, M, Jabado, N, Perek-Polnik, M, Grajkowska, WA, Kim, SK, Rutka, JT, Malkin, D, Tabori, U, Pfister, SM, Korshunov, A, von Deimling, A, and Taylor, MD

Abstract

Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were determined according to subgroup affiliation, demographics, and clinical, prognostic, and molecular features. Integrated genomics approaches were used to identify specific somatic copy number alterations in TERT promoter-mutated and wild-type tumors. Overall, TERT promoter mutations were identified in 21 % of medulloblastomas. Strikingly, the highest frequencies of TERT mutations were observed in SHH (83 %; 55/66) and WNT (31 %; 4/13) medulloblastomas derived from adult patients. Group 3 and Group 4 harbored this alteration in < 5 % of cases and showed no association with increased patient age. The prognostic implications of these mutations were highly subgroup-specific. TERT mutations identified a subset with good and poor prognosis in SHH and Group 4 tumors, respectively. Monosomy 6 was mostly restricted to WNT tumors without TERT mutations. Hallmark SHH focal copy number aberrations and chromosome 10q deletion were mutually exclusive with TERT mutations within SHH tumors. TERT promoter mutations are the most common recurrent somatic point mutation in medulloblastoma, and are very highly enriched in adult SHH and WNT tumors. TERT mutations define a subset of SHH medulloblastoma with distinct demographics, cytogenetics, and outcomes.

Published
2013

41. SURGICAL THERAPIES

Author

Aghi, M., primary, Vogelbaum, M. A., additional, Jolly, D. J., additional, Robbins, J. M., additional, Ostertag, D., additional, Ibanez, C. E., additional, Gruber, H. E., additional, Kasahara, N., additional, Bankiewicz, K., additional, Cloughesy, T. F., additional, Chang, S. M., additional, Butowski, N., additional, Kesari, S., additional, Chen, C., additional, Mikkelsen, T., additional, Landolfi, J., additional, Chiocca, E. A., additional, Elder, J. B., additional, Foltz, G., additional, Pertschuk, D., additional, Anaizi, A., additional, Taylor, C., additional, Kosty, J., additional, Zimmer, L., additional, Theodosopoulos, P., additional, Gantwerker, E., additional, Pensak, M., additional, Grewal, S., additional, Arakawa, Y., additional, Kang, Y., additional, Murata, D., additional, Fujimoto, K.-i., additional, Miyamoto, S., additional, Blagia, M., additional, Paulis, M., additional, Orunesu, G., additional, Serra, S., additional, Akers, J., additional, Ramakrishnan, V., additional, Kim, R., additional, Skog, J., additional, Nakano, I., additional, Pingle, S., additional, Kalinina, J., additional, Breakfield, X., additional, Hochberg, F., additional, Van Meir, E., additional, Carter, B., additional, Czech, T., additional, Nicholson, J., additional, Frappaz, D., additional, Kortmann, R.-D., additional, Alapetite, C., additional, Garre, M.-L., additional, Ricardi, U., additional, Saran, F., additional, Calaminus, G., additional, Hamer, P. D. W., additional, Hendriks, E., additional, Mandonnet, E., additional, Barkhof, F., additional, Zwinderman, K., additional, Duffau, H., additional, Esquenazi, Y., additional, Johnson, J., additional, Tandon, N., additional, Friedman, E., additional, Lin, Y., additional, Zhu, J.-J., additional, Fujimaki, T., additional, Kobayashi, M., additional, Wakiya, K., additional, Ohta, M., additional, Adachi, J., additional, Fukuoka, K., additional, Suzuki, T., additional, Yanagisawa, T., additional, Matsutani, M., additional, Mishima, K., additional, Sasaki, J., additional, Nishikawa, R., additional, Hoffermann, M., additional, Bruckmann, L., additional, Ali, K. M., additional, Asslaber, M., additional, Payer, F., additional, von Campe, G., additional, Jungk, C., additional, Beigel, B., additional, Abb, V., additional, Herold-Mende, C., additional, Unterberg, A., additional, Kim, J. H., additional, Cho, Y. H., additional, Kim, C. J., additional, Mardor, Y., additional, Nissim, O., additional, Grober, Y., additional, Guez, D., additional, Last, D., additional, Daniels, D., additional, Hoffmann, C., additional, Nass, D., additional, Talianski, A., additional, Spiegelmann, R., additional, Cohen, Z., additional, Zach, L., additional, Marupudi, N., additional, Mittal, S., additional, Michaud, K., additional, Cantin, L., additional, Cottin, S., additional, Dandurand, C., additional, Mohammadi, A., additional, Hawasli, A., additional, Rodriguez, A., additional, Schroeder, J., additional, Laxton, A., additional, Elson, P., additional, Tatter, S., additional, Barnett, G., additional, Leuthardt, E., additional, Moriuchi, S., additional, Dehara, M., additional, Fukunaga, T., additional, Hagiwara, Y., additional, Soda, H., additional, Imakita, M., additional, Nitta, M., additional, Maruyama, T., additional, Iseki, H., additional, Ikuta, S., additional, Tamura, M., additional, Chernov, M., additional, Okamoto, S., additional, Okada, Y., additional, Muragaki, Y., additional, Ohue, S., additional, Kohno, S., additional, Inoue, A., additional, Yamashita, D., additional, Kumon, Y., additional, Ohnishi, T., additional, Oppido, P., additional, Villani, V., additional, Vidiri, A., additional, Pace, A., additional, Pompili, A., additional, Carapella, C., additional, Orringer, D., additional, Lau, D., additional, Niknafs, Y., additional, Piquer, J., additional, Llacer, J. L., additional, Rovira, V., additional, Riesgo, P., additional, Cremades, A., additional, Rotta, R., additional, Levine, N., additional, Prabhu, S., additional, Sawaya, R., additional, Weinberg, J., additional, Rao, G., additional, Tummala, S., additional, Tilley, C., additional, Rovin, R., additional, Kassam, A., additional, Schwartz, C., additional, Romagna, A., additional, Thon, N., additional, Tonn, J.-C., additional, Schwarz, S. B., additional, Kreth, F.-W., additional, Sonoda, Y., additional, Shibahara, I., additional, Saito, R., additional, Kanamori, M., additional, Kumabe, T., additional, Tominaga, T., additional, Steele, C., additional, Lawrence, J., additional, Winn, R., additional, Rachinger, W., additional, Simon, M., additional, Dutzmann, S., additional, Feigl, G., additional, Kremenevskaya, N., additional, Whelan, H., additional, Kelly, M., additional, Jogel, S., additional, Kaufmann, B., additional, Foy, A., additional, Lew, S., additional, Quirk, B., additional, Yong, R. L., additional, Wu, T., additional, Mihatov, N., additional, Shen, M. J., additional, Brown, M. A., additional, Zaghloul, K. A., additional, Park, G. E., additional, and Park, J. K., additional

Published
2013
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42. PEDIATRICS CLINICAL RESEARCH

Author

Antony, R., primary, Zagardo, M., additional, Gujrati, M., additional, Lin, J., additional, Antony, R., additional, Al-Rahawan, M., additional, Broniscer, A., additional, Bhardwaj, R., additional, Hampton, C., additional, Ozols, V., additional, Chakravadhanula, M., additional, Bouffet, E., additional, Hawkins, C., additional, Scheinemann, K., additional, Zelcer, S., additional, Johnston, D., additional, Lafay-Cousin, L., additional, Larouche, V., additional, Jabado, N., additional, Carret, A. S., additional, Hukin, J., additional, Eisenstat, D., additional, Pond, G., additional, Poskitt, K., additional, Wilson, B., additional, Bartels, U., additional, Tabori, U., additional, Dhall, G., additional, Haley, K., additional, Finlay, J., additional, Rushing, T., additional, Sposto, R., additional, Seeger, R., additional, Garvin, J., additional, Rupani, K., additional, Stark, E., additional, Anderson, R., additional, Feldstein, N., additional, Grill, J., additional, Hargrave, D., additional, Massimino, M., additional, Jaspan, T., additional, Varlet, P., additional, Jones, C., additional, Morgan, P., additional, Le Deley, M. C., additional, Azizi, A., additional, Canete, A., additional, Saran, F., additional, Bachir, J., additional, Bubuteishvili-Pacaud, L., additional, Rousseau, R., additional, Vassal, G., additional, Gupta, S., additional, Robinson, N., additional, Dhir, N., additional, Wong, K., additional, Zhou, S., additional, Kumabe, T., additional, Kawaguchi, T., additional, Saito, R., additional, Kanamori, M., additional, Yamashita, Y., additional, Sonoda, Y., additional, Tominaga, T., additional, Miyagawa, T., additional, Nwachukwu, C., additional, Youland, R., additional, Laack, N., additional, Filipek, I., additional, Drogosiewicz, M., additional, Polnik, M. P.-, additional, Swieszkowska, E., additional, Dembowska-Baginska, B., additional, Jurkiewicz, E., additional, Perek, D., additional, Grajkowska, W., additional, Roszkowski, M., additional, Sobol, G., additional, Musiol, K., additional, Wachowiak, J., additional, Kazmierczak, B., additional, Pogorzelski, J. P. -, additional, Mlynarski, W., additional, Szewczyk, B. Z.-, additional, Wysocki, M., additional, Niedzielska, E., additional, Kowalczyk, J., additional, Slusarz, H. W. -, additional, Balwierz, W., additional, Czepko, E. Z. -, additional, Szolkiewicz, A., additional, Perek-Polnik, M., additional, Lastowska, M., additional, Chojnacka, M., additional, Tarasinska, M., additional, Perreault, S., additional, Chao, K., additional, Ramaswamy, V., additional, Shih, D., additional, Remke, M., additional, Luu, B., additional, Schubert, S., additional, Fisher, P., additional, Partap, S., additional, Vogel, H., additional, Taylor, M., additional, Goumnerova, L., additional, Cho, Y.-J., additional, Robison, N., additional, Brown, R., additional, Cloughesy, T., additional, Davidson, T. B., additional, Krieger, M., additional, Berger, M., additional, Perry, A., additional, Gilles, F., additional, Finlay, J. L., additional, Khemani, J., additional, Britt, B., additional, Grimm, J., additional, Ruge, M. I., additional, Blau, T., additional, Hafkemeyer, V., additional, Hamisch, C., additional, Klinger, K., additional, Simon, T., additional, Sadighi, Z., additional, Ellezam, B., additional, Guindani, M., additional, Ater, J., additional, Shimizu, Y., additional, Arai, H., additional, Miyajima, M., additional, Shimoji, K., additional, Kondo, A., additional, Shinohara, E., additional, Perkins, S., additional, DeWees, T., additional, Slavc, I., additional, Chocholous, M., additional, Leiss, U., additional, Haberler, C., additional, Peyrl, A., additional, Azizi, A. A., additional, Dieckmann, K., additional, Woehrer, A., additional, Dorfer, C., additional, Czech, T., additional, Spence, T., additional, Picard, D., additional, Barszczyk, M., additional, Kim, S.-K., additional, Ra, Y.-S., additional, Fangusaro, J., additional, Toledano, H., additional, Nakamura, H., additional, Fan, X., additional, Muraszko, K. M., additional, Ng, H.-K., additional, Halliday, W., additional, Shago, M., additional, Hawkins, C. E., additional, Huang, A., additional, Suzuki, M., additional, van Zanten, S. V., additional, Jansen, M., additional, van Vuurden, D., additional, Hulleman, E., additional, Idema, S., additional, Noske, D., additional, Wolf, N., additional, Hendrikse, H., additional, Vandertop, P., additional, Kaspers, G. J., additional, Muller, K., additional, Schlamann, A., additional, Warmuth-Metz, M., additional, Pietsch, T., additional, Pietschmann, S., additional, Kortmann, R.-D., additional, Kramm, C. M., additional, von Bueren, A. O., additional, Walston, S., additional, Williams, T., additional, Hamstra, D., additional, Oh, K., additional, Pelloski, C., additional, Zhukova, N., additional, Pole, J., additional, Mistry, M., additional, Fried, I., additional, Lapperiere, N., additional, Dirks, P., additional, An, J., additional, Alon, N., additional, Nathan, P., additional, Greenberg, M., additional, and Malkin, D., additional

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2013
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43. EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

Author

Aaberg-Jessen, C., primary, Fogh, L., additional, Halle, B., additional, Jensen, V., additional, Brunner, N., additional, Kristensen, B. W., additional, Abe, T., additional, Momii, Y., additional, Watanabe, J., additional, Morisaki, I., additional, Natsume, A., additional, Wakabayashi, T., additional, Fujiki, M., additional, Aldaz, B., additional, Fabius, A. W. M., additional, Silber, J., additional, Harinath, G., additional, Chan, T. A., additional, Huse, J. T., additional, Anai, S., additional, Hide, T., additional, Nakamura, H., additional, Makino, K., additional, Yano, S., additional, Kuratsu, J.-i., additional, Balyasnikova, I. V., additional, Prasol, M. S., additional, Kanoija, D. K., additional, Aboody, K. S., additional, Lesniak, M. S., additional, Barone, T., additional, Burkhart, C., additional, Purmal, A., additional, Gudkov, A., additional, Gurova, K., additional, Plunkett, R., additional, Barton, K., additional, Misuraca, K., additional, Cordero, F., additional, Dobrikova, E., additional, Min, H., additional, Gromeier, M., additional, Kirsch, D., additional, Becher, O., additional, Pont, L. B., additional, Kloezeman, J., additional, van den Bent, M., additional, Kanaar, R., additional, Kremer, A., additional, Swagemakers, S., additional, French, P., additional, Dirven, C., additional, Lamfers, M., additional, Leenstra, S., additional, Balvers, R., additional, Kleijn, A., additional, Lawler, S., additional, Gong, X., additional, Andres, A., additional, Hanson, J., additional, Delashaw, J., additional, Bota, D., additional, Chen, C.-C., additional, Yao, N.-W., additional, Chuang, W.-J., additional, Chang, C., additional, Chen, P.-Y., additional, Huang, C.-Y., additional, Wei, K.-C., additional, Cheng, Y., additional, Dai, Q., additional, Morshed, R., additional, Han, Y., additional, Auffinger, B., additional, Wainwright, D., additional, Zhang, L., additional, Tobias, A., additional, Rincon, E., additional, Thaci, B., additional, Ahmed, A., additional, He, C., additional, Lesniak, M., additional, Choi, Y. A., additional, Pandya, H., additional, Gibo, D. M., additional, Fokt, I., additional, Priebe, W., additional, Debinski, W., additional, Chornenkyy, Y., additional, Agnihotri, S., additional, Buczkowicz, P., additional, Rakopoulos, P., additional, Morrison, A., additional, Barszczyk, M., additional, Hawkins, C., additional, Chung, S., additional, Decollogne, S., additional, Luk, P., additional, Shen, H., additional, Ha, W., additional, Day, B., additional, Stringer, B., additional, Hogg, P., additional, Dilda, P., additional, McDonald, K., additional, Moore, S., additional, Hayden-Gephart, M., additional, Bergen, J., additional, Su, Y., additional, Rayburn, H., additional, Edwards, M., additional, Scott, M., additional, Cochran, J., additional, Das, A., additional, Varma, A. K., additional, Wallace, G. C., additional, Dixon-Mah, Y. N., additional, Vandergrift, W. A., additional, Giglio, P., additional, Ray, S. K., additional, Patel, S. J., additional, Banik, N. L., additional, Dasgupta, T., additional, Olow, A., additional, Yang, X., additional, Mueller, S., additional, Prados, M., additional, James, C. D., additional, Haas-Kogan, D., additional, Dave, N. D., additional, Desai, P. B., additional, Gudelsky, G. A., additional, Chow, L. M. L., additional, LaSance, K., additional, Qi, X., additional, Driscoll, J., additional, Ebsworth, K., additional, Walters, M. J., additional, Ertl, L. S., additional, Wang, Y., additional, Berahovic, R. D., additional, McMahon, J., additional, Powers, J. P., additional, Jaen, J. C., additional, Schall, T. J., additional, Eroglu, Z., additional, Portnow, J., additional, Sacramento, A., additional, Garcia, E., additional, Raubitschek, A., additional, Synold, T., additional, Esaki, S., additional, Rabkin, S., additional, Martuza, R., additional, Wakimoto, H., additional, Ferluga, S., additional, Tome, C. L., additional, Forde, H. E., additional, Netland, I. A., additional, Sleire, L., additional, Skeie, B., additional, Enger, P. O., additional, Goplen, D., additional, Giladi, M., additional, Tichon, A., additional, Schneiderman, R., additional, Porat, Y., additional, Munster, M., additional, Dishon, M., additional, Weinberg, U., additional, Kirson, E., additional, Wasserman, Y., additional, Palti, Y., additional, Gramatzki, D., additional, Staudinger, M., additional, Frei, K., additional, Peipp, M., additional, Weller, M., additional, Grasso, C., additional, Liu, L., additional, Berlow, N., additional, Davis, L., additional, Fouladi, M., additional, Gajjar, A., additional, Huang, E., additional, Hulleman, E., additional, Hutt, M., additional, Keller, C., additional, Li, X.-N., additional, Meltzer, P., additional, Quezado, M., additional, Quist, M., additional, Raabe, E., additional, Spellman, P., additional, Truffaux, N., additional, van Vurden, D., additional, Wang, N., additional, Warren, K., additional, Pal, R., additional, Grill, J., additional, Monje, M., additional, Green, A. L., additional, Ramkissoon, S., additional, McCauley, D., additional, Jones, K., additional, Perry, J. A., additional, Ramkissoon, L., additional, Maire, C., additional, Shacham, S., additional, Ligon, K. L., additional, Kung, A. L., additional, Zielinska-Chomej, K., additional, Grozman, V., additional, Tu, J., additional, Viktorsson, K., additional, Lewensohn, R., additional, Gupta, S., additional, Mladek, A., additional, Bakken, K., additional, Carlson, B., additional, Boakye-Agyeman, F., additional, Kizilbash, S., additional, Schroeder, M., additional, Reid, J., additional, Sarkaria, J., additional, Hadaczek, P., additional, Ozawa, T., additional, Soroceanu, L., additional, Yoshida, Y., additional, Matlaf, L., additional, Singer, E., additional, Fiallos, E., additional, Cobbs, C. S., additional, Hashizume, R., additional, Tom, M., additional, Ihara, Y., additional, Santos, R., additional, Torre, J. D. L., additional, Lepe, E., additional, Waldman, T., additional, James, D., additional, Huang, X., additional, Yu-Jen, L., additional, Gupta, N., additional, Solomon, D., additional, Zhang, Z., additional, Hayashi, T., additional, Adachi, K., additional, Nagahisa, S., additional, Hasegawa, M., additional, Hirose, Y., additional, Gephart, M. H., additional, Su, Y. S., additional, Hingtgen, S., additional, Kasmieh, R., additional, Nesterenko, I., additional, Figueiredo, J.-L., additional, Dash, R., additional, Sarkar, D., additional, Fisher, P., additional, Shah, K., additional, Horne, E., additional, Diaz, P., additional, Stella, N., additional, Huang, C., additional, Yang, H., additional, Wei, K., additional, Huang, T., additional, Hlavaty, J., additional, Ostertag, D., additional, Espinoza, F. L., additional, Martin, B., additional, Petznek, H., additional, Rodriguez-Aguirre, M., additional, Ibanez, C., additional, Kasahara, N., additional, Gunzburg, W., additional, Gruber, H., additional, Pertschuk, D., additional, Jolly, D., additional, Robbins, J., additional, Hurwitz, B., additional, Yoo, J. Y., additional, Bolyard, C., additional, Yu, J.-G., additional, Wojton, J., additional, Zhang, J., additional, Bailey, Z., additional, Eaves, D., additional, Cripe, T., additional, Old, M., additional, Kaur, B., additional, Serwer, L., additional, Le Moan, N., additional, Ng, S., additional, Butowski, N., additional, Krtolica, A., additional, Cary, S. P. L., additional, Johns, T., additional, Greenall, S., additional, Donoghue, J., additional, Adams, T., additional, Karpel-Massler, G., additional, Westhoff, M.-A., additional, Kast, R. E., additional, Dwucet, A., additional, Wirtz, C. R., additional, Debatin, K.-M., additional, Halatsch, M.-E., additional, Merkur, N., additional, Kievit, F., additional, Stephen, Z., additional, Wang, K., additional, Kolstoe, D., additional, Ellenbogen, R., additional, Zhang, M., additional, Kitange, G., additional, Haefner, E., additional, Knubel, K., additional, Pernu, B. M., additional, Sufit, A., additional, Pierce, A. M., additional, Nelson, S. K., additional, Keating, A. K., additional, Jensen, S. S., additional, Lachowicz, J., additional, Demeule, M., additional, Regina, A., additional, Tripathy, S., additional, Curry, J.-C., additional, Nguyen, T., additional, Castaigne, J.-P., additional, Davis, T., additional, Davis, A., additional, Tanaka, K., additional, Keating, T., additional, Getz, J., additional, Kapp, G. T., additional, Romero, J. M., additional, Lee, S., additional, Ramisetti, S., additional, Slagle-Webb, B., additional, Sharma, A., additional, Connor, J., additional, Lee, W.-S., additional, Kluk, M., additional, Aster, J. C., additional, Ligon, K., additional, Sun, S., additional, Lee, D., additional, Ho, A. S. W., additional, Pu, J. K. S., additional, Zhang, Z.-q., additional, Lee, N. P., additional, Day, P. J. R., additional, Leung, G. K. K., additional, Liu, Z., additional, Liu, X., additional, Madhankumar, A. B., additional, Miller, P., additional, Webb, B., additional, Connor, J. R., additional, Yang, Q. X., additional, Lobo, M., additional, Green, S., additional, Schabel, M., additional, Gillespie, Y., additional, Woltjer, R., additional, Pike, M., additional, Lu, Y.-J., additional, Luchman, H. A., additional, Stechishin, O., additional, Nguyen, S., additional, Cairncross, J. G., additional, Weiss, S., additional, Lun, X., additional, Wells, J. C., additional, Hao, X., additional, Grinshtein, N., additional, Kaplan, D., additional, Luchman, A., additional, Senger, D., additional, Robbins, S., additional, Madhankumar, A., additional, Rizk, E., additional, Payne, R., additional, Park, A., additional, Pang, M., additional, Harbaugh, K., additional, Wilisch-Neumann, A., additional, Pachow, D., additional, Kirches, E., additional, Mawrin, C., additional, McDonell, S., additional, Liang, J., additional, Piao, Y., additional, Nguyen, N., additional, Yung, A., additional, Verhaak, R., additional, Sulman, E., additional, Stephan, C., additional, Lang, F., additional, de Groot, J., additional, Mizobuchi, Y., additional, Okazaki, T., additional, Kageji, T., additional, Kuwayama, K., additional, Kitazato, K. T., additional, Mure, H., additional, Hara, K., additional, Morigaki, R., additional, Matsuzaki, K., additional, Nakajima, K., additional, Nagahiro, S., additional, Kumala, S., additional, Heravi, M., additional, Devic, S., additional, Muanza, T., additional, Knubel, K. H., additional, Neuwelt, A., additional, Wu, Y. J., additional, Donson, A., additional, Vibhakar, R., additional, Venkatamaran, S., additional, Amani, V., additional, Neuwelt, E., additional, Rapkin, L., additional, Foreman, N., additional, Ibrahim, F., additional, New, P., additional, Cui, K., additional, Zhao, H., additional, Chow, D., additional, Stephen, W., additional, Nozue-Okada, K., additional, Nagane, M., additional, McDonald, K. L., additional, Ogawa, D., additional, Chiocca, E., additional, Godlewski, J., additional, Patel, A., additional, Pasupuleti, N., additional, Gorin, F., additional, Valenzuela, A., additional, Leon, L., additional, Carraway, K., additional, Ramachandran, C., additional, Nair, S., additional, Quirrin, K.-W., additional, Khatib, Z., additional, Escalon, E., additional, Melnick, S., additional, Phillips, A., additional, Boghaert, E., additional, Vaidya, K., additional, Ansell, P., additional, Shalinsky, D., additional, Zhang, Y., additional, Voorbach, M., additional, Mudd, S., additional, Holen, K., additional, Humerickhouse, R., additional, Reilly, E., additional, Parab, S., additional, Diago, O., additional, Ryken, T., additional, Agarwal, S., additional, Al-Keilani, M., additional, Alqudah, M., additional, Sibenaller, Z., additional, Assemolt, M., additional, Sai, K., additional, Li, W.-y., additional, Li, W.-p., additional, Chen, Z.-p., additional, Saito, R., additional, Sonoda, Y., additional, Kanamori, M., additional, Yamashita, Y., additional, Kumabe, T., additional, Tominaga, T., additional, Sarkar, G., additional, Curran, G., additional, Jenkins, R., additional, Scharnweber, R., additional, Kato, Y., additional, Lin, J., additional, Everson, R., additional, Soto, H., additional, Kruse, C., additional, Liau, L., additional, Prins, R., additional, Semenkow, S., additional, Chu, Q., additional, Eberhart, C., additional, Sengupta, R., additional, Marassa, J., additional, Piwnica-Worms, D., additional, Rubin, J., additional, Shai, R., additional, Pismenyuk, T., additional, Moshe, I., additional, Fisher, T., additional, Freedman, S., additional, Simon, A., additional, Amariglio, N., additional, Rechavi, G., additional, Toren, A., additional, Yalon, M., additional, Shimazu, Y., additional, Kurozumi, K., additional, Ichikawa, T., additional, Fujii, K., additional, Onishi, M., additional, Ishida, J., additional, Oka, T., additional, Watanabe, M., additional, Nasu, Y., additional, Kumon, H., additional, Date, I., additional, Sirianni, R. W., additional, McCall, R. L., additional, Spoor, J., additional, van der Kaaij, M., additional, Geurtjens, M., additional, Veiseh, O., additional, Fang, C., additional, Leung, M., additional, Strohbehn, G., additional, Atsina, K.-K., additional, Patel, T., additional, Piepmeier, J., additional, Zhou, J., additional, Saltzman, W. M., additional, Takahashi, M., additional, Valdes, G., additional, Inagaki, A., additional, Kamijima, S., additional, Hiraoka, K., additional, Micewicz, E., additional, McBride, W. H., additional, Iwamoto, K. S., additional, Gruber, H. E., additional, Robbins, J. M., additional, Jolly, D. J., additional, McCully, C., additional, Bacher, J., additional, Thomas, T., additional, Murphy, R., additional, Steffen-Smith, E., additional, McAllister, R., additional, Pastakia, D., additional, Widemann, B., additional, Chen, P., additional, Hua, M., additional, Liu, H., additional, Woolf, E. C., additional, Abdelwahab, M. G., additional, Fenton, K. E., additional, Liu, Q., additional, Turner, G., additional, Preul, M. C., additional, Scheck, A. C., additional, Shen, W., additional, Brown, D., additional, Pedersen, H., additional, Hariono, S., additional, Yao, T.-W., additional, Sidhu, A., additional, Weiss, W. A., additional, Nicolaides, T. P., additional, and Olusanya, T., additional

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2013
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44. LAB-IMMUNOLOGY RESEARCH

Author

Fujita, M., primary, Zhang, R., additional, Nakata, S., additional, Kuzushima, K., additional, Wainwright, D. A., additional, Balyasnikova, I. V., additional, Auffinger, B., additional, Ahmed, A. U., additional, Han, Y., additional, Lesniak, M. S., additional, Knight, A., additional, Arnouk, H., additional, Gillespie, G. Y., additional, Britt, W., additional, Su, Y., additional, Lowdell, M. W., additional, Lamb, L. S., additional, Wang, J., additional, Leiss, L., additional, Choi, B. D., additional, Kuan, C.-T., additional, Cai, M., additional, Bigner, D. D., additional, Sampson, J. H., additional, Shibahara, I., additional, Saito, R., additional, Kanamori, M., additional, Sonoda, Y., additional, Kumabe, T., additional, Kikuchi, T., additional, So, T., additional, Ishii, N., additional, Tominaga, T., additional, Zhang, L., additional, Wang, H., additional, Zhang, I., additional, Chen, X., additional, Da Fonseca, A., additional, Fan, H., additional, Badie, B., additional, Sayour, E. J., additional, McLendon, P., additional, Reynolds, R., additional, McLendon, R., additional, Mitchell, D. A., additional, Sanchez-Perez, L., additional, Pham, C., additional, Snyder, D., additional, Xie, W., additional, Cui, X., additional, McConnell, M. J., additional, Broadley, K. W., additional, Farrand, K., additional, Authier, A., additional, Brown, J. H., additional, Hunn, M., additional, Hermans, I., additional, Cantini, G., additional, Pisati, F., additional, Pessina, S., additional, Finocchiaro, G., additional, Pellegatta, S., additional, Yeung, J. T., additional, Hamilton, R., additional, Pollack, I., additional, Jakacki, R., additional, Okada, H., additional, Choi, B., additional, Schmittling, R. J., additional, Flores, C., additional, Johnson, L., additional, Archer, G. A., additional, Raychaudhuri, B., additional, Rayman, P., additional, Huang, P., additional, Ireland, J., additional, Donnola, S., additional, Hamburdzumyan, D., additional, Finke, J., additional, Vogelbaum, M. A., additional, Batich, K., additional, Reap, E., additional, Archer, G., additional, Sampson, J., additional, Mitchell, D., additional, Martin, A. M., additional, Nirschl, C., additional, Polanczyk, M., additional, Cohen, K. J., additional, Pardoll, D. M., additional, Drake, C. G., additional, Lim, M., additional, Rutledge, W. C., additional, Kong, J., additional, Gao, J., additional, Gutman, D. A., additional, Cooper, L. A., additional, Chisolm, C., additional, Scarpace, L., additional, Mikkelsen, T., additional, Saltz, J. H., additional, Moreno, C. S., additional, Brat, D. J., additional, Everson, R. G., additional, Lisiero, D. N., additional, Soto, H., additional, Liau, L. M., additional, Prins, R. M., additional, Gonzalez, G. C., additional, Chae, M., additional, Peterson, T. E., additional, Parney, I. F., additional, and Johnson, A. J., additional

Published
2012
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45. MEDICAL AND NEURO-ONCOLOGY

Author

Prithviraj, G. K., primary, Sommers, S. R., additional, Jump, R. L., additional, Halmos, B., additional, Chambless, L. B., additional, Parker, S. L., additional, Hassam-Malani, L., additional, McGirt, M. J., additional, Thompson, R. C., additional, Hunter, K., additional, Chamberlain, M. C., additional, Le, E. M., additional, Lee, E. L. T., additional, Sadighi, Z. S., additional, Pearlman, M. L., additional, Slopis, J. M., additional, Vats, T. S., additional, Khatua, S., additional, DeVito, N. C., additional, Yu, M., additional, Chen, R., additional, Pan, E., additional, Cloughesy, T., additional, Raizer, J., additional, Drappatz, J., additional, Gerena-Lewis, M., additional, Rogerio, J., additional, Yacoub, S., additional, Desjardin, A., additional, Groves, M. D., additional, DeGroot, J., additional, Loghin, M., additional, Conrad, C. A., additional, Hess, K., additional, Ni, J., additional, Ictech, S., additional, Yung, W. A., additional, Porter, A. B., additional, Dueck, A. C., additional, Karlin, N. J., additional, Olson, J., additional, Silber, J., additional, Reiner, A. S., additional, Panageas, K. S., additional, Iwamoto, F. M., additional, Cloughesy, T. F., additional, Aldape, K. D., additional, Rivera, A. L., additional, Eichler, A. F., additional, Louis, D. N., additional, Paleologos, N. A., additional, Fisher, B. J., additional, Ashby, L. S., additional, Cairncross, J. G., additional, Roldan, G. B., additional, Wen, P. Y., additional, Ligon, K. L., additional, Shiff, D., additional, Robins, H. I., additional, Rocque, B. G., additional, Mason, W. P., additional, Weaver, S. A., additional, Green, R. M., additional, Kamar, F. G., additional, Abrey, L. E., additional, DeAngelis, L. M., additional, Jhanwar, S. C., additional, Rosenblum, M. K., additional, Lassman, A. B., additional, Cachia, D., additional, Alderson, L., additional, Moser, R., additional, Smith, T., additional, Yunus, S., additional, Saito, K., additional, Mukasa, A., additional, Narita, Y., additional, Tabei, Y., additional, Shinoura, N., additional, Shibui, S., additional, Saito, N., additional, Flechl, B., additional, Ackerl, M., additional, Sax, C., additional, Dieckmann, K., additional, Crevenna, R., additional, Widhalm, G., additional, Preusser, M., additional, Marosi, C., additional, Ay, C., additional, Dunkler, D., additional, Pabinger, I., additional, Zielinski, C., additional, Belongia, M., additional, Jogal, S., additional, Schlingensiepen, K.-H., additional, Bogdahn, U., additional, Stockhammer, G., additional, Mahapatra, A. K., additional, Venkataramana, N. K., additional, Oliushine, V., additional, Parfenov, V., additional, Poverennova, I., additional, Hau, P., additional, Jachimczak, P., additional, Heinrichs, H., additional, Mammoser, A. G., additional, Shonka, N. A., additional, de Groot, J. F., additional, Shibahara, I., additional, Sonoda, Y., additional, Kumabe, T., additional, Saito, R., additional, Kanamori, M., additional, Yamashita, Y., additional, Watanabe, M., additional, Ishioka, C., additional, Tominaga, T., additional, Silvani, A., additional, Gaviani, P., additional, Lamperti, E., additional, Botturi, A., additional, DiMeco, F., additional, Broggi, G., additional, Fariselli, L., additional, Solero, C. L., additional, Salmaggi, A., additional, Woyshner, E. A., additional, Shu, F., additional, Oh, Y. S., additional, Iganej, S., additional, Singh, G., additional, Vemuri, S. L., additional, Theeler, B. J., additional, Ellezam, B., additional, Gilbert, M. R., additional, Aoki, T., additional, Kobayashi, H., additional, Takano, S., additional, Nishikawa, R., additional, Nagane, M., additional, Muragaki, Y., additional, Sugiyama, K., additional, Kuratsu, J., additional, Matsutani, M., additional, Langford, L. A., additional, Puduvalli, V. K., additional, Shen, D., additional, Chen, Z.-p., additional, Zhang, J.-p., additional, Bedekar, D., additional, Rand, S., additional, Connelly, J., additional, Malkin, M., additional, Paulson, E., additional, Mueller, W., additional, Schmainda, K., additional, Gallego, O., additional, Benavides, M., additional, Segura, P. P., additional, Balana, C., additional, Gil, M., additional, Berrocal, A., additional, Reynes, G., additional, Garcia, J. L., additional, Murata, P., additional, Bague, S., additional, Quintana, M. J., additional, Vasishta, V. G., additional, Kobayashi, K., additional, Tanaka, M., additional, Tsuchiya, K., additional, Shiokawa, Y., additional, Bavle, A. A., additional, Ayyanar, K., additional, Prado, M. P., additional, Hess, K. R., additional, Liu, V., additional, de Groot, J., additional, Loghin, M. E., additional, Colman, H., additional, Levin, V. A., additional, Alfred Yung, W. K., additional, Hackney, J. R., additional, Palmer, C. 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W., additional, Carter, B., additional, Kesari, S., additional, Kong, X.-T., additional, Sparagana, S., additional, Belousova, E., additional, Jozwiak, S., additional, Korf, B., additional, Frost, M., additional, Kuperman, R., additional, Kohrman, M., additional, Witt, O., additional, Wu, J., additional, Flamini, R., additional, Jansen, A., additional, Curtalolo, P., additional, Thiele, E., additional, Whittemore, V., additional, De Vries, P., additional, Ford, J., additional, Shah, G., additional, Cauwel, H., additional, Edrich, P., additional, Sahmoud, T., additional, Franz, D., additional, Khasraw, M., additional, Brown, C., additional, Ashley, D. M., additional, Rosenthal, M. A., additional, Jiang, X., additional, Mou, Y. g., additional, Chen, Z. p., additional, Oh, M., additional, kim, E., additional, Chang, J., additional, Juratli, T. 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M., additional, Jacob, K., additional, Gerges, N., additional, Montpetit, A., additional, Nantel, A., additional, Albrecht, S., additional, Jabado, N., additional, Shah, K., additional, Di, K., additional, Linskey, M., additional, Thon, N., additional, Eigenbrod, S., additional, Kreth, S., additional, Lutz, J., additional, Tonn, J.-C., additional, Kretzschmar, H., additional, Peraud, A., additional, Kreth, F.-W., additional, Muggeri, A. D., additional, Alderuccio, J. P., additional, Diez, B. D., additional, Jiang, P., additional, Chao, Y., additional, Gallagher, M., additional, Kim, R., additional, Pastorino, S., additional, Fogal, V., additional, Rudnick, J. D., additional, Bresee, C., additional, Rogatko, A., additional, Sakowsky, S., additional, Franco, M., additional, Lim, S., additional, Lopez, A., additional, Yu, L., additional, Ryback, K., additional, Tsang, V., additional, Lill, M., additional, Steinberg, A., additional, Sheth, R., additional, Grimm, S., additional, Helenowski, I., additional, Rademaker, A., additional, Nunes, F. P., additional, Merker, V., additional, Jennings, D., additional, Caruso, P., additional, Muzikansky, A., additional, Stemmer-Rachamimov, A., additional, Plotkin, S., additional, Spalding, A. C., additional, Vitaz, T. W., additional, Sun, D. A., additional, Parsons, S., additional, Welch, M. R., additional, Omuro, A., additional, Beal, K., additional, Correa, D., additional, Chan, T., additional, DeAngelis, L., additional, Gavrilovic, I., additional, Nolan, C., additional, Hormigo, A., additional, Kaley, T., additional, Mellinghoff, I., additional, Grommes, C., additional, Panageas, K., additional, Reiner, A., additional, Barradas, R., additional, Abrey, L., additional, Gutin, P., additional, Lee, S. Y., additional, Slagle-Webb, B., additional, Glantz, M. J., additional, Connor, J. R., additional, Schlimper, C. A., additional, Schlag, H., additional, Stoffels, G., additional, Weber, F., additional, Krueger, D. A., additional, Care, M. M., additional, Holland, K., additional, Agricola, K., additional, Tudor, C., additional, Byars, A., additional, Franz, D. N., additional, Rice, L., additional, Chandler, J., additional, Levy, R., additional, Muro, K., additional, Nayak, L., additional, Norden, A. D., additional, Kaley, T. J., additional, Thomas, A. A., additional, Fadul, C. E., additional, Meyer, L. P., additional, Lallana, E. C., additional, Gilbert, M., additional, Aldape, K., additional, De Groot, J., additional, Conrad, C., additional, Levin, V., additional, Groves, M., additional, Chris, P., additional, Puduvalli, V., additional, Nagpal, S., additional, Feroze, A., additional, Recht, L., additional, Rangarajan, H. G., additional, Kieran, M. W., additional, Scott, R. M., additional, Lew, S. M., additional, Firat, S. Y., additional, Segura, A. D., additional, Jogal, S. A., additional, Kumthekar, P. U., additional, Grimm, S. A., additional, Avram, M., additional, Patel, J., additional, Kaklamani, V., additional, McCarthy, K., additional, Cianfrocca, M., additional, Gradishar, W., additional, Mulcahy, M., additional, Von Roenn, J., additional, Galanis, E., additional, Anderson, S. K., additional, Lafky, J. M., additional, Kaufmann, T. J., additional, Uhm, J. H., additional, Giannini, C., additional, Kumar, S. K., additional, Northfelt, D. W., additional, Flynn, P. J., additional, Buckner, J. C., additional, Omar, A. I., additional, Schiff, D., additional, Delios, A., additional, Jakubowski, A., additional, Melguizo-Gavilanes, I., additional, Qiao, W., additional, Wang, X., additional, Hashemi-Sadraei, N., additional, Bawa, H., additional, Rahmathulla, G., additional, Patel, M., additional, Elson, P., additional, Stevens, G., additional, Peereboom, D., additional, Vogelbaum, M., additional, Weil, R., additional, Barnett, G., additional, Ahluwalia, M. S., additional, Alvord, E. C., additional, Rockne, R. C., additional, Rockhill, J. K., additional, Rostomily, R., additional, Lai, A., additional, Wardlaw, J., additional, Spence, A. M., additional, Swanson, K. R., additional, Zadeh, G., additional, Alahmadi, H., additional, Wilson, J., additional, Gentili, F., additional, Beumer, J. J., additional, Wright, J., additional, Takebe, N., additional, Gaur, R., additional, Werner-Wasik, M., additional, Gupta, A. J., additional, Campos-Gines, A., additional, Le, K., additional, Arango, C., additional, Richards, M., additional, Landeros, M., additional, Juan, H., additional, Chang, J. H., additional, Kim, J. S., additional, Cho, J. H., additional, Seo, C. O., additional, Baldock, A. L., additional, Rockne, R., additional, Canoll, P., additional, Born, D., additional, Yagle, K., additional, Alexandru, D., additional, Bota, D., additional, Linskey, M. E., additional, Nabeel, S., additional, Raval, S. N., additional, Rosenow, J., additional, Bredel, M., additional, New, P. Z., additional, Plotkin, S. R., additional, Supko, J. G., additional, Curry, W. T., additional, Chi, A. S., additional, Gerstner, E. R., additional, Batchelor, T. T., additional, Hashemi, N., additional, Chao, S. T., additional, Weil, R. J., additional, Suh, J. H., additional, Vogelbaum, M. A., additional, Stevens, G. H., additional, Barnett, G. H., additional, Corwin, D., additional, Holdsworth, C., additional, Stewart, R., additional, Swanson, K., additional, Graber, J. J., additional, Anderson, A. R., additional, Jeyapalan, S., additional, Goldman, M., additional, Boxerman, J., additional, Donahue, J., additional, Elinzano, H., additional, Evans, D., additional, O'Connor, B., additional, Puthawala, M. Y., additional, Oyelese, A., additional, Cielo, D., additional, Blitstein, M., additional, Dargush, M., additional, Santaniello, A., additional, Constantinou, M., additional, DiPetrillo, T., additional, Safran, H., additional, Halpin, C., additional, Barker, F. G., additional, Maher, E. A., additional, Ganji, S., additional, DeBerardinis, R., additional, Hatanpaa, K., additional, Rakheja, D., additional, Yang, X.-L., additional, Mashimo, T., additional, Raisanen, J., additional, Madden, C., additional, Mickey, B., additional, Malloy, C., additional, Bachoo, R., additional, Choi, C., additional, Ranjan, T., additional, Yono, N., additional, Han, S. J., additional, Sun, M., additional, Berger, M. S., additional, Aghi, M., additional, Gupta, N., additional, and Parsa, A. T., additional

Published
2011
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47. Pre-clinical Experimental Therapeutics and Pharmacology

Author

Jensen, R. L., primary, Gilliespie, D., additional, Ajewung, N., additional, Faure, R., additional, Kamnasaran, D., additional, Poirier, D., additional, Tamura, K., additional, Wakimoto, H., additional, Rabkin, S. D., additional, Martuza, R. L., additional, Shah, K., additional, Hashizume, R., additional, Aoki, Y., additional, Serwer, L. P., additional, Drummond, D., additional, Noble, C., additional, Park, J., additional, Bankiewicz, K., additional, James, D. C., additional, Gupta, N., additional, Agerholm-Larsen, B., additional, Iversen, H. K., additional, Jensen, K. S., additional, Moller, J., additional, Ibsen, P., additional, Mahmood, F., additional, Gehl, J., additional, Corem, E., additional, Ram, Z., additional, Daniels, D., additional, Last, D., additional, Shneor, R., additional, Salomon, S., additional, Perlstein, B., additional, Margel, S., additional, Mardor, Y., additional, Charest, G., additional, Fortin, D., additional, Mathieu, D., additional, Sanche, L., additional, Paquette, B., additional, Li, H.-F., additional, Hariono, S., additional, Dasgupta, T., additional, Kim, J.-S., additional, Haas-Kogan, D., additional, Weiss, W. A., additional, James, C. D., additional, Waldman, T., additional, Nicolaides, T., additional, Ozawa, T., additional, Rao, S., additional, Sun, H., additional, Ng, C., additional, De La Torre, J., additional, Santos, R., additional, Prados, M., additional, Butowski, N., additional, Michaud, K., additional, Solomon, D. A., additional, Prados, M. D., additional, Pandya, H., additional, Gibo, D., additional, Debinski, W., additional, Vinchon-Petit, S., additional, Jarnet, D., additional, Jadaud, E., additional, Feuvret, L., additional, Garcion, E., additional, Menei, P., additional, Chen, R., additional, Yu, J.-C., additional, Liu, C., additional, Jaffer, Z. M., additional, Chabala, J. C., additional, Winssinger, N., additional, Rubenstein, A. E., additional, Emdad, L., additional, Kothari, H., additional, Qadeer, Z., additional, Binello, E., additional, Germano, I., additional, Hirschberg, H., additional, Baek, S.-K., additional, Kwon, Y. J., additional, Sun, C. H., additional, Li, S. C., additional, Madsen, S., additional, Liu, T., additional, Wang, S.-W., additional, Gibo, D. M., additional, Fan, Q.-W., additional, Cheng, C., additional, Hackett, C., additional, Feldman, M., additional, Houseman, B. T., additional, Oakes, S. A., additional, Debnath, J., additional, Shokat, K. M., additional, Sai, K., additional, Chen, F., additional, Qiu, Z., additional, Mou, Y., additional, Zhang, X., additional, Yang, Q., additional, Chen, Z., additional, Patel, T. R., additional, Zhou, J., additional, Piepmeier, J. M., additional, Saltzman, W. M., additional, Banerjee, S., additional, Kaul, A., additional, Gianino, S. M., additional, Christians, U., additional, Gutmann, D. H., additional, Wu, J., additional, Shen, R., additional, Puduvalli, V., additional, Koul, D., additional, Alfred Yung, W. K., additional, Yun, J., additional, Sonabend, A., additional, Stuart, M., additional, Yanagihara, T., additional, Dashnaw, S., additional, Brown, T., additional, McCormick, P., additional, Romanov, A., additional, Sebastian, M., additional, Canoll, P., additional, Bruce, J. N., additional, Piao, L., additional, Joshi, K., additional, Lee, R. J., additional, Nakano, I., additional, Madsen, S. J., additional, Chou, C. C., additional, Blickenstaff, J. W., additional, Sun, C.-H., additional, Zhou, Y.-H., additional, Tome, C. M. L., additional, Wykosky, J., additional, Palma, E., additional, Nduom, E., additional, Machaidze, R., additional, Kaluzova, M., additional, Wang, Y., additional, Nie, S., additional, Hadjipanayis, C., additional, Saito, R., additional, Nakamura, T., additional, Sonoda, Y., additional, Kumabe, T., additional, Tominaga, T., additional, Lun, X., additional, Zemp, F., additional, Zhou, H., additional, Stechishin, O., additional, Kelly, J. J., additional, Weiss, S., additional, Hamilton, M. G., additional, Cairncross, G., additional, Rabinovich, B. A., additional, Bell, J., additional, McFadden, G., additional, Senger, D. L., additional, Forsyth, P. A., additional, Kang, P., additional, Jane, E. P., additional, Premkumar, D. R., additional, Pollack, I. F., additional, Yoo, J. Y., additional, Haseley, A., additional, Bratasz, A., additional, Powell, K., additional, Chiocca, E. A., additional, Kaur, B., additional, Johns, T. G., additional, Ferruzzi, P., additional, Mennillo, F., additional, De Rosa, A., additional, Rossi, M., additional, Giordano, C., additional, Magrini, R., additional, Benedetti, G., additional, Pericot, G. l., additional, Magnoni, L., additional, Mori, E., additional, Thomas, R., additional, Tunici, P., additional, Bakker, A., additional, Pradarelli, J., additional, Kaka, A., additional, Alvarez-Breckenridge, C., additional, Pan, Q., additional, Teknos, T., additional, Cen, L., additional, Ostrem, J. L., additional, Schroeder, M. A., additional, Mladek, A. C., additional, Fink, S. R., additional, Jenkins, R. B., additional, Sarkaria, J. N., additional, Madhankumar, A. B., additional, Slagle-Webb, B., additional, Park, A., additional, Pang, M., additional, Klinger, M., additional, Harbaugh, K. S., additional, Sheehan, J. M., additional, Connor, J. R., additional, Chen, T. C., additional, Wang, W., additional, Hofman, F. M., additional, Drummond, D. C., additional, Noble, C. O., additional, Park, J. W., additional, Zhou, Y., additional, Marks, J. D., additional, Alonso, M. M., additional, Gomez-Manzano, C., additional, Cortes-Santiago, N., additional, Roche, F. P., additional, Fueyo, J., additional, Johannessen, T.-C. A., additional, Grudic, A., additional, Tysnes, B. B., additional, Nigro, J., additional, Bjerkvig, R., additional, Joshi, A. D., additional, Parsons, W., additional, Velculescu, V. E., additional, Riggins, G. J., additional, Bindra, R. S., additional, Jasin, M., additional, Powell, S. N., additional, Fu, J., additional, Shen, R.-J., additional, Colman, H., additional, Lang, F. F., additional, Jensen, M. R., additional, Friedman, G. K., additional, Haas, M., additional, Cassady, K. A., additional, Gillespie, G. Y., additional, Nguyen, V., additional, Murphy, L. T., additional, Beauchamp, A. S., additional, Hollingsworth, C. K., additional, Mintz, A., additional, Garg, S., additional, Kridel, S., additional, Conrad, C. A., additional, Madden, T., additional, Ji, Y., additional, Priebe, W., additional, Seleverstov, O., additional, Purow, B. W., additional, Grant, G. A., additional, Wilson, C., additional, Campbell, M., additional, Humphries, P., additional, Li, S., additional, Li, J., additional, Johnson, A., additional, Bigner, D., additional, Dewhirst, M., additional, Pokorny, J. L., additional, Kitange, G. J., additional, Carlson, B. L., additional, Suphangul, M., additional, Petro, B., additional, Mukhtar, L., additional, Baig, M. S., additional, Villano, J., additional, Mahmud, N., additional, Keir, S. T., additional, Reardon, D. A., additional, Watson, M., additional, Shore, G. C., additional, Bigner, D. D., additional, Friedman, H. S., additional, and Gururangan, S., additional

Published
2010
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