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Your search keyword '"Kumar, Bijender"' showing total 320 results
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320 results on '"Kumar, Bijender"'

2. Increased expression of CD70 in relapsed acute myeloid leukemia after hypomethylating agents

Author

Marques-Piubelli, Mario L., Kumar, Bijender, Basar, Rafet, Panowski, Siler, Srinivasan, Surabhi, Norwood, Kevin, Prashad, Sacha, Szenes, Victoria, Balakumaran, Arun, Arandhya, Akanksha, Lu, Wei, Khan, Khaja, Duenas, Daniela, McAllen, Salome, Gomez, Javier A, Burks, Jared K., Acharyal, Sunil, Borthakur, Gautam, Wang, Wei-Lien, Wang, Wei, Wang, Sa, Solis, Luisa M., Marin, David, Rezvani, Katayoun, Daher, May, and Vega, Francisco

Published
2024
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15. Drowsiness Detection System Using PPG Sensor’s Measured Physiological Parameter

Author

Tripathi, Jyoti, Chand, Satish, Kumar, Bijender, Ghansiyal, Adrija, Nema, Anshula, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Khanna, Ashish, editor, Gupta, Deepak, editor, Bhattacharyya, Siddhartha, editor, Hassanien, Aboul Ella, editor, Anand, Sameer, editor, and Jaiswal, Ajay, editor

Published
2022
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22. Synthesis of waterborne acrylic copolymer resin as a binding agent for the development of water-based inks in the printing application

Author

Sharma, Bhavna, Sauraj, Singh, Kumar, Bijender, Pandey, Arun, Dutt, Dharm, Negi, Yuvraj Singh, Maji, Pradip K., and Kulshreshtha, Anurag

Subjects
Printing-ink -- Composition, Acrylic resins -- Usage, Polyesters -- Usage, Engineering and manufacturing industries, Science and technology
Abstract

In this study, a new waterborne acrylic copolymer resin (acrylic-co-resin) was synthesized to develop water-based printing inks on polyester (PET) film. The synthesized acrylic resin showed good water solubility, high acid value (120 mg KOH/g), about 57% solid content. The developed water-based inks (cyan, magenta, and yellow) exhibited small particle size ( KEYWORDS acrylic resin, adhesion, printing, water-based printing ink, 1 | INTRODUCTION Printing ink plays an essential role in the packaging area, and the demand for printing inks is increasing day-by-day all over the world. [1,2] Due to the [...]

Published
2021
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29. TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax

Author

Tyagi, Anudishi, primary, Jaggupilli, Appalaraju, additional, Ly, Stanley, additional, Yuan, Bin, additional, El-Dana, Fouad, additional, Hegde, Venkatesh L., additional, Anand, Vivek, additional, Kumar, Bijender, additional, Puppala, Mamta, additional, Yin, Zheng, additional, Wong, Stephen T. C., additional, Mollard, Alexis, additional, Vankayalapati, Hariprasad, additional, Foulks, Jason M., additional, Warner, Steven L., additional, Daver, Naval, additional, Borthakur, Gautam, additional, and Battula, V. Lokesh, additional

Published
2023
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40. TP-0184 inhibits FLT3/ACVR1to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax

Author

Tyagi, Anudishi, Jaggupilli, Appalaraju, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Hegde, Venkatesh L., Anand, Vivek, Kumar, Bijender, Puppala, Mamta, Yin, Zheng, Wong, Stephen T. C., Mollard, Alexis, Vankayalapati, Hariprasad, Foulks, Jason M., Warner, Steven L., Daver, Naval, Borthakur, Gautam, and Battula, V. Lokesh

Abstract

We identified activin A receptor type I (ACVR1), a member of the TGF-β superfamily, as a factor favoring acute myeloid leukemia (AML) growth and a new potential therapeutic target. ACVR1is overexpressed in FLT3-mutated AML and inhibition of ACVR1expression sensitized AML cells to FLT3 inhibitors. We developed a novel ACVR1inhibitor, TP-0184, which selectively caused growth arrest in FLT3-mutated AML cell lines. Molecular docking and in vitro kinase assays revealed that TP-0184 binds to both ACVR1and FLT3 with high affinity and inhibits FLT3/ACVR1downstream signaling. Treatment with TP-0184 or in combination with BCL2 inhibitor, venetoclax dramatically inhibited leukemia growth in FLT3-mutated AML cell lines and patient-derived xenograft models in a dose-dependent manner. These findings suggest that ACVR1is a novel biomarker and plays a role in AML resistance to FLT3 inhibitors and that FLT3/ACVR1dual inhibitor TP-0184 is a novel potential therapeutic tool for AML with FLT3mutations.

Published
2024
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43. Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia

Author

Zhang, Bin, Nguyen, Le Xuan Truong, Li, Ling, Zhao, Dandan, Kumar, Bijender, Wu, Herman, Lin, Allen, Pellicano, Francesca, Hopcroft, Lisa, Su, Yu-Lin, Copland, Mhairi, Holyoake, Tessa L, Kuo, Calvin J, Bhatia, Ravi, Snyder, David S, Ali, Haris, Stein, Anthony S, Brewer, Casey, Wang, Huafeng, McDonald, Tinisha, Swiderski, Piotr, Troadec, Estelle, Chen, Ching-Cheng, Dorrance, Adrienne, Pullarkat, Vinod, Yuan, Yate-Ching, Perrotti, Danilo, Carlesso, Nadia, Forman, Stephen J, Kortylewski, Marcin, Kuo, Ya-Huei, and Marcucci, Guido

Subjects
Bone marrow -- Genetic aspects -- Health aspects, MicroRNA -- Health aspects, Stem cells -- Genetic aspects -- Health aspects, Chronic myeloid leukemia -- Genetic aspects -- Development and progression -- Care and treatment, Gene expression -- Health aspects, Biological sciences, Health
Abstract

Leukemia stem cells (LSCs) in individuals with chronic myelogenous leukemia (CML) (hereafter referred to as CML LSCs) are responsible for initiating and maintaining clonal hematopoiesis. These cells persist in the bone marrow (BM) despite effective inhibition of BCR-ABL kinase activity by tyrosine kinase inhibitors (TKIs). Here we show that although the microRNA (miRNA) miR-126 supported the quiescence, self-renewal and engraftment capacity of CML LSCs, miR-126 levels were lower in CML LSCs than in long-term hematopoietic stem cells (LT-HSCs) from healthy individuals. Downregulation of miR-126 levels in CML LSCs was due to phosphorylation of Sprouty-related EVH1-domain-containing 1 (SPRED1) by BCR-ABL, which led to inhibition of the RAN-exportin-5-RCC1 complex that mediates miRNA maturation. Endothelial cells (ECs) in the BM supply miR-126 to CML LSCs to support quiescence and leukemia growth, as shown using mouse models of CML in which Mir126a (encoding miR-126) was conditionally knocked out in ECs and/or LSCs. Inhibition of BCR-ABL by TKI treatment caused an undesired increase in endogenous miR-126 levels, which enhanced LSC quiescence and persistence. Mir126a knockout in LSCs and/or ECs, or treatment with a miR-126 inhibitor that targets miR-126 expression in both LSCs and ECs, enhanced the in vivo anti-leukemic effects of TKI treatment and strongly diminished LSC leukemia-initiating capacity, providing a new strategy for the elimination of LSCs in individuals with CML., Author(s): Bin Zhang (corresponding author) [1]; Le Xuan Truong Nguyen [1, 2]; Ling Li [1]; Dandan Zhao [1]; Bijender Kumar [1]; Herman Wu [1]; Allen Lin [1]; Francesca Pellicano [3]; [...]

Published
2018
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44. Methods and figures from ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model

Author

Srideshikan, Sargur Madabushi, primary, Brooks, Jamison, primary, Zuro, Darren, primary, Kumar, Bijender, primary, Sanchez, James, primary, Echavarria Parra, Liliana, primary, Orellana, Marvin, primary, Vishwasrao, Paresh, primary, Nair, Indu, primary, Chea, Junie, primary, Poku, Kofi, primary, Bowles, Nicole, primary, Miller, Aaron, primary, Ebner, Todd, primary, Molnar, Justin, primary, Rosenthal, Joseph, primary, Vallera, Daniel A., primary, Wong, Jeffrey Y.C., primary, Stein, Anthony S., primary, Colcher, David, primary, Shively, John E., primary, Yazaki, Paul J., primary, and Hui, Susanta K., primary

Published
2023
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45. Data from ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model

Author

Srideshikan, Sargur Madabushi, primary, Brooks, Jamison, primary, Zuro, Darren, primary, Kumar, Bijender, primary, Sanchez, James, primary, Echavarria Parra, Liliana, primary, Orellana, Marvin, primary, Vishwasrao, Paresh, primary, Nair, Indu, primary, Chea, Junie, primary, Poku, Kofi, primary, Bowles, Nicole, primary, Miller, Aaron, primary, Ebner, Todd, primary, Molnar, Justin, primary, Rosenthal, Joseph, primary, Vallera, Daniel A., primary, Wong, Jeffrey Y.C., primary, Stein, Anthony S., primary, Colcher, David, primary, Shively, John E., primary, Yazaki, Paul J., primary, and Hui, Susanta K., primary

Published
2023
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