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7. Synthesis and characterization of nucleoside derivatives, n-(benzoyl)-n-(deoxyguanosin-8-yl)4-aminobiphenyl and n-(2'-deoxyguanosin-8-yl)4-aminobiphenyl via alpha-phenyl-n-(4-biphenyl)nitrone.

Author

Mallesha H, Kumar KR, and Rangappa KS

Subjects
Aminobiphenyl Compounds pharmacology, DNA Adducts, Deoxyguanosine pharmacology, Hydrogen-Ion Concentration, Models, Chemical, Aminobiphenyl Compounds chemical synthesis, Deoxyguanosine analogs & derivatives, Deoxyguanosine chemical synthesis, Nucleosides chemical synthesis, Nucleosides pharmacology, Organometallic Compounds pharmacology
Abstract

Lead tetraacetate (LTA) oxidation of alpha-Phenyl-N-(4-bipheny])nitrone (8) to give a new ultimate carcinogen, N-acetoxy-N-benzoyl-4-aminobiphenyl (9) which was reacted with deoxyguanosine (dG) at pH 6.9 to give nucleoside derivative, N-(benzoyl)-N-(deoxyguanosin-8-yl)-4-aminobiphenyl (10). Following debenzoylation with sodium carbonate-methanol leads to N-(2'-deoxyguanosin-8-yl)-4-aminobiphenyl (11).

Published
2002
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