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Byline: Mritunjai. Kumar, Ashutosh. Tiwari, Shakti. Kumar, Rajni. Singh Objective: One or more inexcitable motor (IM) nerves are common during electrodiagnostic (EDx) study in Guillain-Barré syndrome (GBS). This study assessed [...]

Byline: Vinayak. Jatale, Ashutosh. Tiwari, Mritunjai. Kumar, Ravi. Gupta, Niraj. Kumar Objective: To compare the prevalence and characteristics of migraine and tension-type headache (TTH) among patients with Parkinson's disease (PD), [...]

Byline: Ishita. Desai, Ravi. Gupta, Mritunjai. Kumar, Ashutosh. Tiwari, Niraj. Kumar Objective: To assess the impact of coronavirus disease 2019 (COVID-19) pandemic on sleep disorders among Parkinson's disease (PD) patients [...]

Byline: Ishita. Desai, Ashutosh. Tiwari, Mritunjai. Kumar, Jagbir. Singh, Nikita. Dhar, Niraj. Kumar Sir, Cerebral venous sinus thrombosis (CVST) primarily affects young and middle-aged population. It accounts for 0.5-1% of [...]

Byline: Mritunjai. Kumar, Nikita. Dhar, Govind. Madhaw, Ashutosh. Tiwari, Niraj. Kumar Dear Sir, Scrub typhus (ST) is a zoonotic disease, caused by Rickettsia, Orientia tsutsugamushi (OT), an obligate intracellular gram-negative [...]

Byline: Nishant. Goyal, Jitender. Chaturvedi, Pankaj. Kandwal, Priyanka. Gupta, Ashutosh. Kaushal, Mritunjai. Kumar Background: 'White-cord syndrome' is an extremely rare entity following decompression of cervical cord in which post-operative reperfusion [...]

Byline: Nikita. Dhar, Mritunjai. Kumar, Ashutosh. Tiwari, Ishita. Desai, Govind. Madhaw, Niraj. Kumar Objective: To compare the efficacy and safety of thrombolysis using Tenecteplase (TNK) versus alteplase in acute ischaemic [...]

The overall incidence of stroke in the perioperative period following noncardiac, nonneurologic, and noncarotid surgery has been reported to be between 0.1% and 0.8%. Thrombolysis in the postoperative stroke is controversial, with a possible high risk of surgical site hemorrhage (SSH) and intracerebral hemorrhage. We report a case of an old male who developed an ischemic stroke on postoperative day 0 of transurethral resection of prostate. He was thrombolysed with tenecteplase but developed minor SSH as well as cerebral hemorrhagic transformation (HI2). Both complications were managed with appropriate measures. The patient recovered completely (NIHSS 0) and was discharged 1 week later. To the best of our knowledge, this is the first report of a successful thrombolysis in a patient developing acute ischemic stroke following a major urologic surgery on the day of surgery. [ABSTRACT FROM AUTHOR]

Background To compare the safety and efficacy of sequential anti-tubercular treatment (ATT) regimen with the standard regimen in tuberculous meningitis (TBM). Methods This single-centre, open-label, parallel group randomized controlled trial was conducted from May 2017 to June 2019 in India. Treatment-naïve patients with TBM fulfilling the inclusion criteria were randomized to four drug ATT regimens (rifampicin, isoniazid, ethambutol and pyrazinamide) administered either simultaneously (standard arm) or one after another (sequential arm) in a 1 : 1 ratio. The primary endpoint was drug-induced hepatitis (DIH) and the secondary endpoints were in-hospital death and disability at 3 and 6 months using a modified Rankin Scale. Results A total of 97 patients with TBM were recruited; 15 did not meet the inclusion criteria and 2 refused to participate. The median age of the patients was 26 y (range 15–75) and 37 (46.2%) were males. The patients in the sequential arm had fewer cases of DIH (20% vs 42.5%; p=0.03). The patients in the sequential arm had lower in-hospital mortality (2.5% vs 17.5%; p=0.025) and better 6-month outcomes (25.0% vs 50.0%; p=0.02) compared with the standard arm. Conclusions Sequential ATT was associated with a lower frequency of DIH, lower in-hospital mortality and better 6-month outcome. Trial registration Clinical Trials Registry of India (ctri.nic.in) identifier: REF/2016/09/012214/CTRI/2017/10/010072. [ABSTRACT FROM AUTHOR]

Byline: Kolar. Vinod, Mritunjai. Kumar, Kare. Nisar Intravenous immunoglobulin [IVIg] is useful for treating several clinical conditions and is largely considered safe, without major adverse events. Here we report a [...]