Search

Your search keyword '"Kumar, Swatantra"' showing total 192 results
Start Over Author "Kumar, Swatantra"
192 results on '"Kumar, Swatantra"'

10. Desloratadine via its anti-inflammatory and antioxidative properties ameliorates TNBS-induced experimental colitis in rats.

Author

Bhat, Mohammad Aadil, Roy, Supriya, Dhaneshwar, Suneela, Kumar, Swatantra, and Saxena, Shailendra K.

Subjects
INFLAMMATORY bowel diseases, ULCERATIVE colitis, DRUG repositioning, LABORATORY rats, MAST cells, HISTAMINE
Abstract

Intestinal mucosal immune cells, notably mast cells, are pivotal in ulcerative colitis (UC) pathophysiology. Its activation elevates tissue concentrations of histamine. Inhibiting colonic histamine release could be an effective therapeutic strategy for treating UC. Experimental model like 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats mimic human IBD, aiding treatment investigations. Drug repurposing is a promising strategy to explore new indications for established drugs. Desloratadine (DES) is second-generation antihistamine utilized for managing allergies by blocking histamine action in the body. It also has reported anti-inflammatory and antioxidant actions. DES was investigated for its repurposing potential in UC by preclinical screening in TNBS-induced colitis in Wistar rats. Therapeutic efficacy of DES was evaluated both individually and in combination with standard drug 5-aminosalicylicacid (5-ASA). Rats were orally administered DES (10 mg/kg), 5-ASA (25 mg/kg), and DES + 5-ASA (5 mg + 12.15 mg) following the induction of colitis. Parameters including disease activity score rate (DASR), colon/body weight ratio (CBWR), colon length, diameter, pH, histological injury, and scoring were evaluated. Inflammatory biomarkers such as IL-1β, TNF-α, along with reduced glutathione (GSH), and malondialdehyde (MDA) were assessed. Significant protective effects of DES, especially in combination with 5-ASA, against TNBS-induced inflammation were observed as evidenced by reduced DASR, CBWR, and improved colon morphology. Drugs significantly lowered plasma and colon histamine and, cytokines levels. GSH restoration, and decreased MDA content were also observed. DES and DES + 5-ASA demonstrated potential in alleviating colonic inflammation associated with TNBS-induced colitis in rats. The effect can be attributed to its antihistamine, anticytokine, and antioxidative properties. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

18. Pandemic Influenza A Virus (pH1N1)

Author

Saxena, Shailendra K., Maurya, Vimal K., Kumar, Swatantra, Bhatt, Madan L. B., Malik, Yashpal Singh, Series Editor, Singh, Rameshwar, Editorial Board Member, Gehlot, A. K., Editorial Board Member, Raj, G. Dhinakar, Editorial Board Member, Bujarbaruah, K. M., Editorial Board Member, Goyal, Sagar M., Editorial Board Member, Tikoo, Suresh K., Editorial Board Member, Singh, Raj Kumar, editor, and Dhama, Kuldeep, editor

Published
2020
Full Text
View/download PDF

19. Nipah Virus

Author

Saxena, Shailendra K., Maurya, Vimal K., Kumar, Swatantra, Bhatt, Madan L. B., Malik, Yashpal Singh, Series Editor, Singh, Rameshwar, Editorial Board Member, Gehlot, A. K., Editorial Board Member, Raj, G. Dhinakar, Editorial Board Member, Bujarbaruah, K. M., Editorial Board Member, Goyal, Sagar M., Editorial Board Member, Tikoo, Suresh K., Editorial Board Member, Singh, Raj Kumar, editor, and Dhama, Kuldeep, editor

Published
2020
Full Text
View/download PDF

20. Animal Flaviviruses

Author

Saxena, Shailendra K., Kumar, Swatantra, Haikerwal, Amrita, Malik, Yashpal Singh, Series Editor, Singh, Rameshwar, Editorial Board Member, Gehlot, A. K., Editorial Board Member, Raj, G. Dhinakar, Editorial Board Member, Bujarbaruah, K. M., Editorial Board Member, Goyal, Sagar M., Editorial Board Member, Tikoo, Suresh K., Editorial Board Member, Singh, Raj Kumar, editor, and Yadav, Mahendra Pal, editor

Published
2020
Full Text
View/download PDF

21. Nanotoxicology in Medicine

Author

Saxena, Shailendra K., Nyodu, Rajni, Kumar, Swatantra, Maurya, Vimal K., Saxena, Shailendra K., editor, and Khurana, S. M. Paul, editor

Published
2020
Full Text
View/download PDF

40. List of contributors

Author

Aseri, G.K., primary, Augustine, Asha, additional, Aziz, Aiman, additional, Babar, Mustafeez Mujtaba, additional, Baloch, Sana Rasul, additional, Bányai, Krisztián, additional, Bedekar, Megha Kadam, additional, Bharati, Jaya, additional, Bhat, Raja Aadil Hussain, additional, Bhat, Sudipta, additional, Bhatt, Madan L.B., additional, Costa, Emília Oliveira Alves, additional, da Cruz, Alex Silva, additional, da Cruz, Aparecido D., additional, Das, Rakesh, additional, Deb, Rajib, additional, Deol, Pallavi, additional, Dhama, Kuldeep, additional, Doszpoly, Andor, additional, D’Occhio, Michael J., additional, Gautam, Ablesh, additional, Ghosh, Souvik, additional, Golkar-Narenji, Afsaneh, additional, Gul, Alvina, additional, Gupta, Vikas, additional, Jain, Mukta, additional, Joseph, Imelda, additional, Kaleh, Karim, additional, Kaszab, Eszter, additional, Khan, Azhar, additional, Kole, Sajal, additional, Kues, Wilfried A., additional, Kumar, Amit, additional, Kumar, Deepak, additional, Kumar, Dharmendra, additional, Kumar, Naveen, additional, Kumar, Ravi, additional, Kumar, Swatantra, additional, Laaldin, Nayaab, additional, Lanave, Gianvito, additional, Mahajan, Supreeti, additional, Malik, Yashpal Singh, additional, Marton, Szilvia, additional, Maurya, Vimal K., additional, Minasi, Lysa Bernardes, additional, Mishra, S.S., additional, Mitra, Namita, additional, Mozdziak, Paul E., additional, Mukhopadhyay, Chandra Sekhar, additional, Nimmanapalli, Ramadevi, additional, Noor, Aneeqa, additional, Pande, Amit, additional, Pawar, Hitesh N., additional, Petitte, James N., additional, Pigg, Alexis, additional, Pinto, Irene Plaza, additional, Polavarapu, Rathnagiri, additional, Punetha, Meeti, additional, Rajput, Tausif Ahmed, additional, Sahoo, S.N., additional, Sai Kumar, B.A.A., additional, Sarkar, Mihir, additional, Saxena, Ankur, additional, Saxena, Shailendra K., additional, Sengar, Gyanendra Singh, additional, Sharma, Deepansh, additional, Shields, Laruen E., additional, Silva, Danilo Conrado, additional, Singh, Raj Kumar, additional, Sohal, Jagdip Singh, additional, Swain, P., additional, Tiwari, Ashish, additional, Tomar, Shailly, additional, Tripathi, Gayatri, additional, Tyagi, Mudit, additional, Vats, Divyang, additional, Verma, Atul, additional, Verma, Ramneek, additional, Vidyalakshmi, G.M., additional, Wang, Xiaofei, additional, Welch, Rebecca L., additional, and Zamani-Ahmadmahmudi, Mohamad, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results