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Background: Over recent years, the security of the publicly available audio, video and text data has become a big challenge, i.e., social media communication; hence the author presents an exceedingly secure communication system to hide the data from an attentive adversary. Objective: The study aims to design and analyze a novel algorithm to be implemented for message transmission using multi-image LSB steganography and crucial variable-length cryptography. Encoder, decoder and social media as a channel are the main parts of the study. Methods: Various computer techniques like cryptography and steganography with video handling are used to perform the proposed work. The main objective of this work is to implement the raw video as the cover on the QR code image. This image is to be transmitted as information by enshrouding it in the raw footage. Additionally, encryption of QR code image using VLMKG (Variable Length Mixed key Generation) cryptography enhances the reliability of work. The variablelength Key is generated separately to implement the cryptography. Multi-image LSB steganography is imposed with one-bit replacement in the spatial domain. Wavelet Transform (Daubechies family) is applied for denoising, which enhances the accuracy of the received data. Results: The proposed work provides a secure way to transmit any information in the form of QR code image successfully. It is verified with the help of five QR Code images and three raw video groupings. Conclusion: Implementation of LSB steganography, variable-length key cryptography and MATLAB usage had superbly extracted the image features; calculations and the consequences were observed to be palatable.

Peptidic and non-peptidic αvβ6 integrin-binding molecules have been used in the clinic for detection and treatment of tumors expressing αvβ6 integrin, because this protein is expressed in malignant epithelial cells of the oral cavity, pancreas, breast, ovary, colon and stomach carcinomas but it is not expressed in healthy adult tissue except during wound healing and inflammation. This review focuses on the landscape of αvβ6 integrinbinding molecules and their use in cancer treatment and detection, and discusses recent designs for tumor detection, treatment, and immunotherapy. In the last ten years, several reviews abamp;#945;vβ6 integrin-binding molecules and their role in cancer detection and treatment. Firstly, this review describes the role of the αvβ6 integrin in normal tissues, how the expression of this protein is correlated with cancer severity and its role in cancer development. Taking into account the potential of αvβ6 integrin-binding molecules in detection and treatment of specific tumors, special attention is given to several high-affinity αvβ6 integrin-binding peptides used for tumor imaging; particularly, the αvβ6-binding peptide NAVPNLRGDLQVLAQKVART [A20FMDV2], derived from the foot and mouth disease virus. This peptide labeled with either 18F, 111In or with 68Ga has been used for PET imaging of αvβ6 integrin-positive tumors. Moreover, αvβ6 integrin-binding peptides have been used for photoacoustic and fluorescence imaging and could potentially be used in clinical application in cancer diagnosis and intraoperative imaging of αvβ6-integrin positive tumors. Additionally, non-peptidic αvβ6-binding molecules have been designed and used in the clinic for the detection and treatment of αvβ6-expressing tumors. Anti-αvβ6 integrin antibodies are another useful tool for selective identification and treatment of αvβ6 (+) tumors. The utility of these αvβ6 integrin-binding molecules as a tool for tumor detection and treatment is discussed, considering specificity, sensitivity and serum stability. Another use of the αvβ6 integrin-binding peptides is to modify the Ad5 cell tropism for inducing oncolytic activity of αvβ6-integrin positive tumor cells by expressing A20FMDV2 peptide within the fiber knob protein (Ad5NULL-A20). The newly designed oncolytic Ad5NULL-A20 virotherapy is promising for local and systemic targeting of αvβ6-overexpressing cancers. Finally, new evidence has emerged, indicating that chimeric antigen receptor (CAR) containing the αvβ6 integrin- binding peptide on top of CD28+CD3 endodomain displays a potent therapeutic activity in a diverse repertoire of solid tumor models.

Cloud computing offers services to the end users, or the consumers, in a convenient and on-demand fashion. This computing model has several other features which increase its dependency to an incomparable degree, such as resource pooling, pay-per-use (economic), scalability, rapid elasticity, security, and availability. This model allows big or small organizations to get started with the work and to focus primarily on the business modules without worrying about the underlying infrastructure setup costs, i.e., the cost of powerful servers, expensive network devices, etc. Cloud computing finds a very important utility in e-Governance, which allows government applications to offer uninterrupted services to its citizens. Cost-effective, scalable, and secure e-services are possible with the integration of cloud computing. This paper shows the importance of cloud computing in e-Governance.