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Background: COVID-19 is the continuously evolving pandemic affecting billions of people. The viruses are notorious for mutations in them. Novel coronavirus is no exception to mutation and mutated into various strains according to geographical locations. Summary: The recent second and third wave which is actually a resurgence in COVID-19 cases after a steep fall is attributed to the mutation that is occurring in novel coronavirus. Various strains has been isolated and is being under study to tackle their menace. But blaming completely the mutant version of the virus is unjust as there are other factors such as lax implementation of preventive measures, negligence on account of people by not wearing masks and not following physical distancing. The impact of COVID-19 on human organ system is almost negative and affects the functioning of the organ adversely. Therefore proper care must be taken to ensure the safety of oneself. Conclusion: Mutations in viruses cannot be stopped and solution lies within us. By following preventive measures and guidelines issued by WHO and other competent authority can a key to keep oneself self. Also balance diet along with proper exercise can help in these pandemic. More study needs to be done to establish various correlation so than containment plan of COVID-19 can be modifies accordingly.