1. Antihyperlipidemic, Antiatherosclerotic and Cardio-protective Activity of Leaves and Aerial Roots of Heritiera fomes (Sundari) Extract on Alloxan-induced Diabetic Sprague Dawley Rats
- Author
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Sarkar AP, Sutradhar A, Saleh Md, Mondal M, Alam KMK, Wahed TB, Ahmed S, and Kundu SK
- Subjects
Very low-density lipoprotein ,biology ,Traditional medicine ,Computer Networks and Communications ,business.industry ,Hypoglycemia ,medicine.disease ,biology.organism_classification ,chemistry.chemical_compound ,chemistry ,Hardware and Architecture ,Weight loss ,Alloxan ,Hyperlipidemia ,medicine ,Heritiera fomes ,medicine.symptom ,business ,Adverse effect ,Medicinal plants ,Software - Abstract
Background: Hyperlipidemia is one of the leading causes of death in developed as well as in developing countries like Bangladesh. Hyperlipidemia is a major risk factor for early development of atherosclerosis and its cardiovascular complications. The objective of the study was to evaluate antihyperlipidemic, antiathersclerotic and cardio-protective activities of the leaves (LE) and aerial root (AR) extracts of Heritiera fomes (Family: Malvaceae, local name: Sundari) which is a common species in the world’s largest mangrove forest, Sundarbans, major part of which is located in Bangladesh. Methods and findings: Extracts of the powdered LE and AR of Heritiera fomes were obtained using methanol, and the extracts were applied at doses of 250 and 500 mg/kg of body weight, to treat the diabetic rats. Alloxan Monohydrate was used to induce diabetic condition in Sprague dawley rats. Metformin Hydrochloride was also used as a standard drug to treat the diabetic rats in order to compare the efficacy of the plant extracts with that of the standard drug. After 21 days of treatment, the animals were sacrificed and lipid profiles were estimated. The lipid levels were elevated in alloxan-induced diabetic rats as compared to the control rats. Total cholesterol, triglycerides, LDL and VLDL were increased in diabetic rats and the HDL level was significantly (P
- Published
- 2018