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3 results on '"Kunka M. Ramkumar"'

1. Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes in vitro and in vivo

Author

Rashmi Rajappa, Dornadula Sireesh, Magesh B. Salai, Kunka M. Ramkumar, Suryanarayanan Sarvajayakesavulu, and SubbaRao V. Madhunapantula

Subjects
diabetes, streptozotocin, naringenin, Nrf2, MIN6 cells, apoptosis, Therapeutics. Pharmacology, RM1-950
Abstract

Chronic hyperglycemia and unusually high oxidative stress are the key contributors for diabetes in humans. Since nuclear factor E2-related factor 2 (Nrf2) controls the expression of antioxidant- and detoxification genes, it is hypothesized that targeted activation of Nrf2 using phytochemicals is likely to protect pancreatic β-cells, from oxidative damage, thereby mitigates the complications of diabetes. Naringenin is one such activator of Nrf2. However, it is currently not known whether the protective effect of naringenin against streptozotocin (STZ) induced damage is mediated by Nrf2 activation. Hence, the potential of naringenin to activate Nrf2 and protect pancreatic β-cells from STZ-induced damage in MIN6 cells is studied. In MIN6 cells, naringenin could activate Nrf2 and its target genes GST and NQO1, thereby inhibit cellular apoptosis. In animals, administration of 50 mg/kg body weight naringenin, for 45 days, significantly decreased STZ-induced blood glucose levels, normalized the lipid profile, and augmented the levels of antioxidants in pancreatic tissues. Immunohistochemical analysis measuring the number of insulin-positive cells in pancreas showed restoration of insulin expression similar to control animals. Furthermore, naringenin promoted glycolysis while inhibiting gluconeogenesis. In conclusion, naringenin could be a good anti-diabetic agent, which works by promoting Nrf2 levels and by decreasing cellular oxidative stress.

Published
2019
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2. Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes

Author

Rashmi, Rajappa, Dornadula, Sireesh, Magesh B, Salai, Kunka M, Ramkumar, Suryanarayanan, Sarvajayakesavulu, and SubbaRao V, Madhunapantula

Subjects
Pharmacology, diabetes, naringenin, apoptosis, food and beverages, digestive system, streptozotocin, Nrf2, MIN6 cells, Original Research
Abstract

Chronic hyperglycemia and unusually high oxidative stress are the key contributors for diabetes in humans. Since nuclear factor E2-related factor 2 (Nrf2) controls the expression of antioxidant- and detoxification genes, it is hypothesized that targeted activation of Nrf2 using phytochemicals is likely to protect pancreatic β-cells, from oxidative damage, thereby mitigates the complications of diabetes. Naringenin is one such activator of Nrf2. However, it is currently not known whether the protective effect of naringenin against streptozotocin (STZ) induced damage is mediated by Nrf2 activation. Hence, the potential of naringenin to activate Nrf2 and protect pancreatic β-cells from STZ-induced damage in MIN6 cells is studied. In MIN6 cells, naringenin could activate Nrf2 and its target genes GST and NQO1, thereby inhibit cellular apoptosis. In animals, administration of 50 mg/kg body weight naringenin, for 45 days, significantly decreased STZ-induced blood glucose levels, normalized the lipid profile, and augmented the levels of antioxidants in pancreatic tissues. Immunohistochemical analysis measuring the number of insulin-positive cells in pancreas showed restoration of insulin expression similar to control animals. Furthermore, naringenin promoted glycolysis while inhibiting gluconeogenesis. In conclusion, naringenin could be a good anti-diabetic agent, which works by promoting Nrf2 levels and by decreasing cellular oxidative stress.

Published
2018

3. List of Contributors

Author

Padma Ambalam, Frank Antonicelli, Syed Asrafuzzaman, Debasis Bagchi, Philippe Bernard, Elango Bhakkiyalakshmi, Chhanda Biswas, Marco Bonesi, Nabil Bosco, Olivier Cexus, Scott Chaffee, Shampa Chatterjee, Dorothy H.J. Cheong, Sung J. Choe, Amitava Das, Ingrid De Meester, Fernando Del Rosario, Neeraj Dholia, Mukesh Doble, Katia Falasca, Koustav Ganguly, Leema George, Nandini Ghosh, Catherine L. Grimes, Zhaoping He, Elizabeth D. Hood, Melanie-Jayne R. Howes, Shaik Abdul Hussain, Se K. Jeong, Wolfgang Jungraithmayr, Toshihide Kabuki, Yoshihiro Kawasaki, Charmy Kothari, Anis Larbi, Sébastien Le Jan, Eun-Ji Lee, Jeong-Sang Lee, Robert J. Lee, Chae J. Lim, Monica R. Loizzo, Francesco Menichini, Karthik B. Mallilankaraman, Selvaraj Manoj Kumar Kingsley, Derek B. McMahon, James E. Melnyk, Tomohiro Moriya, David L. Moyes, Hye-Kyung Na, Pradeep M.K. Nair, Jun Nishihira, Mie Nishimura, Keedon Park, Kyungho Park, Priyal Patel, Bela Peethambaran, Sheetal Pithva, Julie Plée, Ramesh Pothuraju, Nupoor Prasad, Ravi Kiran Purama, Yongkang Qiao, Maya Raman, Kunka M. Ramkumar, Prerna Ramteke, Marcella Reale, Sashwati Roy, Fumihiko Sakai, Hyndavi Salwa, Venkatesh Sampath, Amy K. Schaefer, Chandan K. Sen, Rahul Shah, Ashish K. Sharma, Minaxi Sharma, Travis M. Sifers, Dina C. Simes, Dornadula Sireesh, Young-Joon Surh, Tania A. Thimraj, Thai Tran, Rosa Tundis, Swapna Upadhyay, Jose P. Vazquez-Medina, Carla S.B. Viegas, Ballambattu Vishnu Bhat, Gwendolyn Vliegen, Elizabeth A. Witherden, Umesh C.S. Yadav, Vengala Rao Yenuganti, and Huihui You

Published
2018
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