837 results on '"Kunos, George"'
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2. The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics
3. Renal Mitochondrial ATP Transporter Ablation Ameliorates Obesity-Induced CKD
4. In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis
5. A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis
6. TOP-312 Functional characterization of intrahepatic CD8+ T lymphocytes in patients with severe alcohol-associated hepatitis
7. Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
8. Neutrophil-Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis.
9. Cholesterol as a modulator of cannabinoid receptor CB2 signaling
10. A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction
11. Preclinical toxicity evaluation of JD5037, a peripherally restricted CB1 receptor inverse agonist, in rats and dogs for treatment of nonalcoholic steatohepatitis
12. Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis
13. Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling
14. Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis
15. Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models
16. Alcohol-associated bowel disease: new insights into pathogenesis
17. Do endocannabinoids acting via hepatic CB-1 contribute to NAFLD and hepatic insulin resistance?
18. Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice
19. Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling
20. Cannabinoid receptors in GtoPdb v.2023.1
21. A human laboratory study on the link between alcohol administration and circulating fibroblast growth factor 21 (FGF21) in individuals with alcohol use disorder
22. Endocannabinoid Signaling via Cannabinoid Receptor 1 Is Involved in Ethanol Preference and Its Age-Dependent Decline in Mice
23. Cannabinoid-Induced Mesenteric Vasodilation through an Endothelial Site Distinct from CB1 or CB2 Receptors
24. Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis
25. Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids
26. Hepatic [beta]-arrestin 2 is essential for maintaining euglycemia
27. A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome
28. Overview of Nonclassical Cannabinoid Receptors
29. Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy
30. The effects of acute alcohol administration on circulating endocannabinoid levels in humans
31. Cannabinoid‐1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy
32. β‐Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice
33. Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase
34. Chronic alcohol produces neuroadaptations to prime dorsal striatal learning
35. 851 PROTECTIVE EFFECTS OF INTESTINAL CD8 T LYMPHOCYTES ON ALCOHOL-INDUCED ORGAN DAMAGE
36. Sa1531 GUT AND LIVER ALDH2 SYNERGISTICALLY PROMOTE ALCOHOL METABOLISM AND CLEARANCE
37. Central Neural Mechanisms in the Cardiovascular Effects of Ethanol
38. Endorphinergic Neurons in the Brainstem: Role in Cardiovascular Regulation
39. Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance
40. Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice
41. Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB₁) receptors in the regenerating liver
42. A Biosynthetic Pathway for Anandamide
43. Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis
44. N-Arachidonoyl L-Serine, an Endocannabinoid-Like Brain Constituent with Vasodilatory Properties
45. Design of novel melanotropin antagonists and agonists for the recently discovered MC3, MC4 and MC5 receptors and their use to determine new biological roles
46. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity
47. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
48. Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1
49. Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia
50. CB 1 R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome
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