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2. Survival Outcomes of Complete Pulmonary Metastasectomy for Head and Neck Squamous Cell Carcinomas

Author

Kuroda H, Koyama S, Mun M, Nakajima J, Funai K, Yoshino I, Yamauchi Y, and Kawamura M

Subjects
pulmonary metastasectomy, head and neck squamous cell carcinoma, pulmonary metastasis, survival outcomes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Hiroaki Kuroda,1 Shin Koyama,1 Mingyon Mun,2 Jun Nakajima,3 Kazuhito Funai,4 Ichiro Yoshino,5 Yoshikane Yamauchi,6 Masafumi Kawamura6 On behalf of the Metastatic Lung Tumor Study Group of Japan1Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan; 2Department of Thoracic Surgical Oncology, Cancer Institute Hospital Japanese Foundation for Cancer Research, Tokyo, Japan; 3Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan; 4First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; 5Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan; 6Department of Surgery, Teikyo University School of Medicine, Tokyo, JapanCorrespondence: Hiroaki Kuroda, Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan, Tel +81-52-762-6111, Fax +81-52-763-5233, Email h-kuroda@aichi-cc.jpPurpose: Metastatic head and neck squamous cell carcinoma (HNSCC) is relatively poor; however, depending on the selected cases, pulmonary metastasectomy can be a practical therapeutic option. This study aimed to identify the outcomes of complete metastasectomy based on each primary site and to investigate unfavorable prognostic factors.Patients and Methods: We used the database from the Metastatic Lung Tumour Study Group of Japan. Between November 1980 and April 2017, 231 patients were deemed eligible. According to anatomy and the current epidemiology of HNSCC, the patients were divided into three groups: nasopharynx, oropharynx, and salivary gland (n = 40, Group 1), oral cavity, tongue, and paranasal sinuses (n = 69, Group 2), and larynx and hypopharynx (n = 122, Group 3).Results: The 5-year overall survival after complete pulmonary metastasectomy was 58.5%, 25.0%, and 46.9% in G1, 2, and 3, respectively (p < 0.01). Multivariate analyses revealed unfavourable prognostic factors to be G2, and pathological maximum diameter was > 20 mm. Therefore, on dividing group 1 and 3 with or without diameter, the 5-year overall survival was significantly worse in HNSCC with a diameter > 20 mm (n = 74) than that in the remnant (n = 88; 61.9% vs 35.5%; p < 0.01).Conclusion: According to the multi-institutional Japanese data, pulmonary metastasectomy from HNSCC indicates a potential survival benefit. Oral cavity, tongue, and paranasal sinuses cancer, and tumour size (> 20 mm) were poor prognostic factors for pulmonary metastasectomy from head and neck cancer.Keywords: pulmonary metastasectomy, head and neck squamous cell carcinoma, pulmonary metastasis, survival outcomes

Published
2022

3. Science with the Cherenkov Telescope Array

Author

Consortium, The Cherenkov Telescope Array, Acharya, B. S., Agudo, I., Samarai, I. Al, Alfaro, R., Alfaro, J., Alispach, C., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrosi, G., Antolini, E., Antonelli, L. A., Aramo, C., Araya, M., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ashley, M., Backes, M., Balazs, C., Balbo, M., Ballester, O., Ballet, J., Bamba, A., Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Becherini, Y., Belfiore, A., Benbow, W., Berge, D., Bernardini, E., Bernardini, M. G., Bernardos, M., Bernlöhr, K., Bertucci, B., Biasuzzi, B., Bigongiari, C., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Boisson, C., Bolmont, J., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Bosnjak, Z., Böttcher, M., Braiding, C., Bregeon, J., Brill, A., Brown, A. M., Brun, P., Brunetti, G., Buanes, T., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Canestrari, R., Capalbi, M., Capitanio, F., Caproni, A., Caraveo, P., Cárdenas, V., Carlile, C., Carosi, R., Carquín, E., Carr, J., Casanova, S., Cascone, E., Catalani, F., Catalano, O., Cauz, D., Cerruti, M., Chadwick, P., Chaty, S., Chaves, R. C. G., Chen, A., Chen, X., Chernyakova, M., Chikawa, M., Christov, A., Chudoba, J., Cieślar, M., Coco, V., Colafrancesco, S., Colin, P., Conforti, V., Connaughton, V., Conrad, J., Contreras, J. L., Cortina, J., Costa, A., Costantini, H., Cotter, G., Covino, S., Crocker, R., Cuadra, J., Cuevas, O., Cumani, P., D'Aì, A., D'Ammando, F., D'Avanzo, P., D'Urso, D., Daniel, M., Davids, I., Dawson, B., Dazzi, F., De Angelis, A., Anjos, R. de Cássia dos, De Cesare, G., De Franco, A., Pino, E. M. de Gouveia Dal, de la Calle, I., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., De Lucia, M., de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., De Persio, F., de Souza, V., Deil, C., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Díaz, C., Dib, C., Diebold, S., Djannati-Ataï, A., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Drass, H., Dravins, D., Dubus, G., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Ekoume, T. R. N., Elsässer, D., Ernenwein, J. -P., Espinoza, C., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Falcone, A., Farnier, C., Fasola, G., Fedorova, E., Fegan, S., Fernandez-Alonso, M., Fernández-Barral, A., Ferrand, G., Fesquet, M., Filipovic, M., Fioretti, V., Fontaine, G., Fornasa, M., Fortson, L., Coromina, L. Freixas, Fruck, C., Fujita, Y., Fukazawa, Y., Funk, S., Füßling, M., Gabici, S., Gadola, A., Gallant, Y., Garcia, B., López, R. Garcia, Garczarczyk, M., Gaskins, J., Gasparetto, T., Gaug, M., Gerard, L., Giavitto, G., Giglietto, N., Giommi, P., Giordano, F., Giro, E., Giroletti, M., Giuliani, A., Glicenstein, J. -F., Gnatyk, R., Godinovic, N., Goldoni, P., Gómez-Vargas, G., González, M. M., González, J. M., Götz, D., Graham, J., Grandi, P., Granot, J., Green, A. J., Greenshaw, T., Griffiths, S., Gunji, S., Hadasch, D., Hara, S., Hardcastle, M. J., Hassan, T., Hayashi, K., Hayashida, M., Heller, M., Helo, J. C., Hermann, G., Hinton, J., Hnatyk, B., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Horns, D., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Humensky, T. B., Hütten, M., Iarlori, M., Inada, T., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Iori, M., Ishio, K., Iwamura, Y., Jamrozy, M., Janecek, P., Jankowsky, D., Jean, P., Jung-Richardt, I., Jurysek, J., Kaaret, P., Karkar, S., Katagiri, H., Katz, U., Kawanaka, N., Kazanas, D., Khélifi, B., Kieda, D. B., Kimeswenger, S., Kimura, S., Kisaka, S., Knapp, J., Knödlseder, J., Koch, B., Kohri, K., Komin, N., Kosack, K., Kraus, M., Krause, M., Krauß, F., Kubo, H., Mezek, G. Kukec, Kuroda, H., Kushida, J., La Palombara, N., Lamanna, G., Lang, R. G., Lapington, J., Blanc, O. Le, Leach, S., Lees, J. -P., Lefaucheur, J., de Oliveira, M. A. Leigui, Lenain, J. -P., Lico, R., Limon, M., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., López, M., López-Coto, R., Lu, C. -C., Lucarelli, F., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Maier, G., Majumdar, P., Malaguti, G., Mandat, D., Maneva, G., Manganaro, M., Mangano, S., Marcowith, A., Marín, J., Markoff, S., Martí, J., Martin, P., Martínez, M., Martínez, G., Masetti, N., Masuda, S., Maurin, G., Maxted, N., Mazin, D., Medina, C., Melandri, A., Mereghetti, S., Meyer, M., Minaya, I. A., Mirabal, N., Mirzoyan, R., Mitchell, A., Mizuno, T., Moderski, R., Mohammed, M., Mohrmann, L., Montaruli, T., Moralejo, A., Morcuende-Parrilla, D., Mori, K., Morlino, G., Morris, P., Morselli, A., Moulin, E., Mukherjee, R., Mundell, C., Murach, T., Muraishi, H., Murase, K., Nagai, A., Nagataki, S., Nagayoshi, T., Naito, T., Nakamori, T., Nakamura, Y., Niemiec, J., Nieto, D., Nikołajuk, M., Nishijima, K., Noda, K., Nosek, D., Novosyadlyj, B., Nozaki, S., O'Brien, P., Oakes, L., Ohira, Y., Ohishi, M., Ohm, S., Okazaki, N., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Osborne, J. P., Ostrowski, M., Otte, N., Oya, I., Padovani, M., Paizis, A., Palatiello, M., Palatka, M., Paoletti, R., Paredes, J. M., Pareschi, G., Parsons, R. D., Pe'er, A., Pech, M., Pedaletti, G., Perri, M., Persic, M., Petrashyk, A., Petrucci, P., Petruk, O., Peyaud, B., Pfeifer, M., Piano, G., Pisarski, A., Pita, S., Pohl, M., Polo, M., Pozo, D., Prandini, E., Prast, J., Principe, G., Prokhorov, D., Prokoph, H., Prouza, M., Pühlhofer, G., Punch, M., Pürckhauer, S., Queiroz, F., Quirrenbach, A., Rainò, S., Razzaque, S., Reimer, O., Reimer, A., Reisenegger, A., Renaud, M., Rezaeian, A. H., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Riquelme, M., Rivoire, S., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rojas, G., Romano, P., Romeo, G., Rosado, J., Rovero, A. C., Rowell, G., Rudak, B., Rugliancich, A., Rulten, C., Sadeh, I., Safi-Harb, S., Saito, T., Sakaki, N., Sakurai, S., Salina, G., Sánchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Sarkar, S., Satalecka, K., Saturni, F. G., Schioppa, E. J., Schlenstedt, S., Schneider, M., Schoorlemmer, H., Schovanek, P., Schulz, A., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Seitenzahl, I., Semikoz, D., Sergijenko, O., Servillat, M., Shalchi, A., Shellard, R. C., Sidoli, L., Siejkowski, H., Sillanpää, A., Sironi, G., Sitarek, J., Sliusar, V., Slowikowska, A., Sol, H., Stamerra, A., Stanič, S., Starling, R., Stawarz, Ł., Stefanik, S., Stephan, M., Stolarczyk, T., Stratta, G., Straumann, U., Suomijarvi, T., Supanitsky, A. D., Tagliaferri, G., Tajima, H., Tavani, M., Tavecchio, F., Tavernet, J. -P., Tayabaly, K., Tejedor, L. A., Temnikov, P., Terada, Y., Terrier, R., Terzic, T., Teshima, M., Testa, V., Thoudam, S., Tian, W., Tibaldo, L., Tluczykont, M., Peixoto, C. J. Todero, Tokanai, F., Tomastik, J., Tonev, D., Tornikoski, M., Torres, D. F., Torresi, E., Tosti, G., Tothill, N., Tovmassian, G., Travnicek, P., Trichard, C., Trifoglio, M., Pujadas, I. Troyano, Tsujimoto, S., Umana, G., Vagelli, V., Vagnetti, F., Valentino, M., Vallania, P., Valore, L., van Eldik, C., Vandenbroucke, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Vega, A., Vercellone, S., Veres, P., Vergani, S., Verzi, V., Vettolani, G. P., Viana, A., Vigorito, C., Villanueva, J., Voelk, H., Vollhardt, A., Vorobiov, S., Vrastil, M., Vuillaume, T., Wagner, S. J., Wagner, R., Walter, R., Ward, J. E., Warren, D., Watson, J. J., Werner, F., White, M., White, R., Wierzcholska, A., Wilcox, P., Will, M., Williams, D. A., Wischnewski, R., Wood, M., Yamamoto, T., Yamazaki, R., Yanagita, S., Yang, L., Yoshida, T., Yoshiike, S., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zampieri, L., Zandanel, F., Zanin, R., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., Ziegler, A., and Zorn, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The Cherenkov Telescope Array, CTA, will be the major global observatory for very high energy gamma-ray astronomy over the next decade and beyond. The scientific potential of CTA is extremely broad: from understanding the role of relativistic cosmic particles to the search for dark matter. CTA is an explorer of the extreme universe, probing environments from the immediate neighbourhood of black holes to cosmic voids on the largest scales. Covering a huge range in photon energy from 20 GeV to 300 TeV, CTA will improve on all aspects of performance with respect to current instruments. The observatory will operate arrays on sites in both hemispheres to provide full sky coverage and will hence maximize the potential for the rarest phenomena such as very nearby supernovae, gamma-ray bursts or gravitational wave transients. With 99 telescopes on the southern site and 19 telescopes on the northern site, flexible operation will be possible, with sub-arrays available for specific tasks. CTA will have important synergies with many of the new generation of major astronomical and astroparticle observatories. Multi-wavelength and multi-messenger approaches combining CTA data with those from other instruments will lead to a deeper understanding of the broad-band non-thermal properties of target sources. The CTA Observatory will be operated as an open, proposal-driven observatory, with all data available on a public archive after a pre-defined proprietary period. Scientists from institutions worldwide have combined together to form the CTA Consortium. This Consortium has prepared a proposal for a Core Programme of highly motivated observations. The programme, encompassing approximately 40% of the available observing time over the first ten years of CTA operation, is made up of individual Key Science Projects (KSPs), which are presented in this document., Comment: 213 pages, including references and glossary. Version 2: credits and references updated, some figures updated, and author list updated

Published
2017
Full Text
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4. Cherenkov Telescope Array Contributions to the 35th International Cosmic Ray Conference (ICRC2017)

Author

Acero, F., Acharya, B. S., Portella, V. Acín, Adams, C., Agudo, I., Aharonian, F., Samarai, I. Al, Alberdi, A., Alcubierre, M., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Anderson, J., Anduze, M., Angüner, E. O., Antolini, E., Antonelli, L. A., Antonuccio, V., Antoranz, P., Aramo, C., Araya, M., Arcaro, C., Armstrong, T., Arqueros, F., Arrabito, L., Arrieta, M., Asano, K., Asano, A., Ashley, M., Aubert, P., Singh, C. B., Babic, A., Backes, M., Bajtlik, S., Balazs, C., Balbo, M., Ballester, O., Ballet, J., Ballo, L., Balzer, A., Bamba, A., Bandiera, R., Barai, P., Barbier, C., Barcelo, M., Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Bauer, C., Becciani, U., Becherini, Y., Tjus, J. Becker, Bednarek, W., Belfiore, A., Benbow, W., Benito, M., Berge, D., Bernardini, E., Bernardini, M. G., Bernardos, M., Bernhard, S., Bernlöhr, K., Salucci, C. Bertinelli, Bertucci, B., Besel, M. -A., Beshley, V., Bettane, J., Bhatt, N., Bhattacharyya, W., Bhattachryya, S., Biasuzzi, B., Bicknell, G., Bigongiari, C., Biland, A., Bilinsky, A., Bird, R., Bissaldi, E., Biteau, J., Bitossi, M., Blanch, O., Blasi, P., Blazek, J., Boccato, C., Bockermann, C., Boehm, C., Bohacova, M., Boisson, C., Bolmont, J., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Borkowski, J., Bose, R., Bosnjak, Z., Böttcher, M., Boutonnet, C., Bouyjou, F., Bowman, L., Bozhilov, V., Braiding, C., Brau-Nogué, S., Bregeon, J., Briggs, M., Brill, A., Brisken, W., Bristow, D., Britto, R., Brocato, E., Brown, A. M., Brown, S., Brügge, K., Brun, P., Brun, F., Brunetti, L., Brunetti, G., Bruno, P., Bryan, M., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Buson, S., Buss, J., Byrum, K., Caccianiga, A., Cameron, R., Canelli, F., Canestrari, R., Capalbi, M., Capasso, M., Capitanio, F., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Cárdenas, V., Cardenzana, J., Cardillo, M., Carlile, C., Caroff, S., Carosi, R., Carosi, A., Carquín, E., Carr, J., Casandjian, J. -M., Casanova, S., Cascone, E., Castro-Tirado, A. J., Mora, J. Castroviejo, Catalani, F., Catalano, O., Cauz, D., Silva, C. Celestino, Celli, S., Cerruti, M., Chabanne, E., Chadwick, P., Chakraborty, N., Champion, C., Chatterjee, A., Chaty, S., Chaves, R., Chen, A., Chen, X., Cheng, K., Chernyakova, M., Chikawa, M., Chitnis, V. R., Christov, A., Chudoba, J., Cieślar, M., Clark, P., Coco, V., Colafrancesco, S., Colin, P., Colombo, E., Colome, J., Colonges, S., Conforti, V., Connaughton, V., Conrad, J., Contreras, J. L., Cornat, R., Cortina, J., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Covone, G., Cristofari, P., Criswell, S. J., Crocker, R., Croston, J., Crovari, C., Cuadra, J., Cuevas, O., Cui, X., Cumani, P., Cusumano, G., D'Aì, A., D'Ammando, F., D'Avanzo, P., D'Urso, D., Da Vela, P., Dale, Ø., Dang, V. T., Dangeon, L., Daniel, M., Davids, I., Dawson, B., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De Lisio, C., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., De Lucia, M., Neto, J. R. T. de Mello, de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., De Persio, F., de Souza, V., Decock, J., Deil, C., Deiml, P., Del Santo, M., Delagnes, E., Deleglise, G., Reznicek, M. Delfino, Delgado, C., Mengual, J. Delgado, Della Ceca, R., della Volpe, D., Detournay, M., Devin, J., Di Girolamo, T., Di Giulio, C., Di Pierro, F., Di Venere, L., Diaz, L., Díaz, C., Dib, C., Dickinson, H., Diebold, S., Digel, S., Djannati-Ataï, A., Doert, M., Domínguez, A., Prester, D. Dominis, Donnarumma, I., Dorner, D., Doro, M., Dournaux, J. -L., Downes, T., Drake, G., Drappeau, S., Drass, H., Dravins, D., Drury, L., Dubus, G., Morå, K. Dundas, Durkalec, A., Dwarkadas, V., Ebr, J., Eckner, C., Edy, E., Egberts, K., Einecke, S., Eisch, J., Eisenkolb, F., Ekoume, T. R. N., Eleftheriadis, C., Elsässer, D., Emmanoulopoulos, D., Ernenwein, J. -P., Escarate, P., Eschbach, S., Espinoza, C., Evans, P., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Falcone, A., Ramazani, V. Fallah, Farakos, K., Farrell, E., Fasola, G., Favre, Y., Fede, E., Fedora, R., Fedorova, E., Fegan, S., Fernandez-Alonso, M., Fernández-Barral, A., Ferrand, G., Ferreira, O., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovic, M., Fink, D., Finley, J. P., Finley, C., Finoguenov, A., Fioretti, V., Fiorini, M., Flores, H., Foffano, L., Föhr, C., Fonseca, M. V., Font, L., Fontaine, G., Fornasa, M., Fortin, P., Fortson, L., Fouque, N., Fraga, B., Franco, F. J., Coromina, L. Freixas, Fruck, C., Fugazza, D., Fujita, Y., Fukami, S., Fukazawa, Y., Fukui, Y., Funk, S., Furniss, A., Füßling, M., Gabici, S., Gadola, A., Gallant, Y., Galloway, D., Gallozzi, S., Garcia, B., Garcia, A., Gil, R. García, López, R. Garcia, Garczarczyk, M., Gardiol, D., Gargano, F., Gargano, C., Garozzo, S., Garrido-Ruiz, M., Gascon, D., Gasparetto, T., Gaté, F., Gaug, M., Gebhardt, B., Gebyehu, M., Geffroy, N., Genolini, B., Ghalumyan, A., Ghedina, A., Ghirlanda, G., Giammaria, P., Gianotti, F., Giebels, B., Giglietto, N., Gika, V., Gimenes, R., Giommi, P., Giordano, F., Giovannini, G., Giro, E., Giroletti, M., Gironnet, J., Giuliani, A., Glicenstein, J. -F., Gnatyk, R., Godinovic, N., Goldoni, P., Gómez, J. L., Gómez-Vargas, G., González, M. M., González, J. M., Gothe, K. S., Gotz, D., Goullon, J., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Grasseau, G., Gredig, R., Green, A. J., Greenshaw, T., Grenier, I., Griffiths, S., Grillo, A., Grondin, M. -H., Grube, J., Guarino, V., Guest, B., Gueta, O., Gunji, S., Gyuk, G., Hadasch, D., Hagge, L., Hahn, J., Hahn, A., Hakobyan, H., Hara, S., Hardcastle, M. J., Hassan, T., Haubold, T., Haupt, A., Hayashi, K., Hayashida, M., He, H., Heller, M., Helo, J. C., Henault, F., Henri, G., Hermann, G., Hermel, R., Llorente, J. Herrera, Herrero, A., Hervet, O., Hidaka, N., Hinton, J., Hiroshima, N., Hirotani, K., Hnatyk, B., Hoang, J. K., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Hörbe, M., Horns, D., Horvath, P., Houles, J., Hovatta, T., Hrabovsky, M., Hrupec, D., Huet, J. -M., Hughes, G., Hui, D., Hull, G., Humensky, T. B., Hussein, M., Hütten, M., Iarlori, M., Ikeno, Y., Illa, J. M., Impiombato, D., Inada, T., Ingallinera, A., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Ionica, M., Iori, M., Iriarte, A., Ishio, K., Israel, G. L., Iwamura, Y., Jablonski, C., Jacholkowska, A., Jacquemier, J., Jamrozy, M., Janecek, P., Jankowsky, F., Jankowsky, D., Jansweijer, P., Jarnot, C., Jean, P., Johnson, C. 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Mc, McHardy, I., Medina, C., Melandri, A., Melioli, C., Melkumyan, D., Mereghetti, S., Meunier, J. -L., Meures, T., Meyer, M., Micanovic, S., Michael, T., Michałowski, J., Mievre, I., Miller, J., Minaya, I. A., Mineo, T., Mirabel, F., Miranda, J. M., Mirzoyan, R., Mitchell, A., Mizuno, T., Moderski, R., Mohammed, M., Mohrmann, L., Molijn, C., Molinari, E., Moncada, R., Montaruli, T., Monteiro, I., Mooney, D., Moore, P., Moralejo, A., Morcuende-Parrilla, D., Moretti, E., Mori, K., Morlino, G., Morris, P., Morselli, A., Moscato, F., Motohashi, D., Moulin, E., Mueller, S., Mukherjee, R., Munar, P., Mundell, C., Mundet, J., Murach, T., Muraishi, H., Murase, K., Murphy, A., Nagai, A., Nagar, N., Nagataki, S., Nagayoshi, T., Nagesh, B. K., Naito, T., Nakajima, D., Nakamori, T., Nakamura, Y., Nakayama, K., Naumann, D., Nayman, P., Neise, D., Nellen, L., Nemmen, R., Neronov, A., Neyroud, N., Nguyen, T., Nguyen, T. T., Trung, T. Nguyen, Nicastro, L., Nicolau-Kukliński, J., Niemiec, J., Nieto, D., Nievas-Rosillo, M., Nikołajuk, M., Nishijima, K., Nishikawa, K. -I., Nishiyama, G., Noda, K., Nogues, L., Nolan, S., Nosek, D., Nöthe, M., Novosyadlyj, B., Nozaki, S., Nunio, F., O'Brien, P., Oakes, L., Ocampo, C., Ochoa, J. P., Oger, R., Ohira, Y., Ohishi, M., Ohm, S., Okazaki, N., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlati, A., Osborne, J. P., Ostrowski, M., Otte, N., Ou, Z., Ovcharov, E., Oya, I., Ozieblo, A., Padovani, M., Paiano, S., Paizis, A., Palacio, J., Palatiello, M., Palatka, M., Pallotta, J., Panazol, J. -L., Paneque, D., Panter, M., Paoletti, R., Paolillo, M., Papitto, A., Paravac, A., Paredes, J. M., Pareschi, G., Parsons, R. D., Paśko, P., Pavy, S., Pe'er, A., Pech, M., Pedaletti, G., Del Campo, P. Peñil, Perez, A., Pérez-Torres, M. A., Perri, L., Perri, M., Persic, M., Petrashyk, A., Petrera, S., Petrucci, P. -O., Petruk, O., Peyaud, B., Pfeifer, M., Piano, G., Piel, Q., Pieloth, D., Pintore, F., García, C. Pio, Pisarski, A., Pita, S., Pizarro, L., Platos, Ł., Pohl, M., Poireau, V., Pollo, A., Porthault, J., Poutanen, J., Pozo, D., Prandini, E., Prasit, P., Prast, J., Pressard, K., Principe, G., Prokhorov, D., Prokoph, H., Prouza, M., Pruteanu, G., Pueschel, E., Pühlhofer, G., Puljak, I., Punch, M., Pürckhauer, S., Queiroz, F., Quinn, J., Quirrenbach, A., Rafighi, I., Rainò, S., Rajda, P. J., Rando, R., Rannot, R. C., Razzaque, S., Reichardt, I., Reimer, O., Reimer, A., Reisenegger, A., Renaud, M., Reposeur, T., Reville, B., Rezaeian, A. H., Rhode, W., Ribeiro, D., Ribó, M., Richer, M. G., Richtler, T., Rico, J., Rieger, F., Riquelme, M., Ristori, P. R., Rivoire, S., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rojas, G., Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rosen, S., Lees, S. Rosier, Rousselle, J., Rovero, A. C., Rowell, G., Rudak, B., Rugliancich, A., del Mazo, J. E. Ruíz, Rujopakarn, W., Rulten, C., Russo, F., Saavedra, O., Sabatini, S., Sacco, B., Sadeh, I., Hatlen, E. Sæther, Safi-Harb, S., Sahakian, V., Sailer, S., Saito, T., Sakaki, N., Sakurai, S., Salek, D., Greus, F. Salesa, Salina, G., Sanchez, D., Sánchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Santangelo, A., Santos, E. M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Satalecka, K., Sato, Y., Saturni, F. G., Savalle, R., Sawada, M., Schanne, S., Schioppa, E. J., Schlenstedt, S., Schmidt, T., Schmoll, J., Schneider, M., Schoorlemmer, H., Schovanek, P., Schulz, A., Schussler, F., Schwanke, U., Schwarz, J., Schweizer, T., Schwemmer, S., Sciacca, E., Scuderi, S., Seglar-Arroyo, M., Segreto, A., Seitenzahl, I., Semikoz, D., Sergijenko, O., Serre, N., Servillat, M., Seweryn, K., Shah, K., Shalchi, A., Sharma, M., Shellard, R. C., Shilon, I., Sidoli, L., Sidz, M., Siejkowski, H., Silk, J., Sillanpää, A., Simone, D., Singh, B. B., Sironi, G., Sitarek, J., Sizun, P., Sliusar, V., Slowikowska, A., Smith, A., Sobczyńska, D., Sokolenko, A., Sol, H., Sottile, G., Springer, W., Stahl, O., Stamerra, A., Stanič, S., Starling, R., Staszak, D., Stawarz, Ł., Steenkamp, R., Stefanik, S., Stegmann, C., Steiner, S., Stella, C., Stephan, M., Sternberger, R., Sterzel, M., Stevenson, B., Stodulska, M., Stodulski, M., Stolarczyk, T., Stratta, G., Straumann, U., Stuik, R., Suchenek, M., Suomijarvi, T., Supanitsky, A. 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Troyano, Tsirou, M., Tsujimoto, S., Tsuru, T., Uchiyama, Y., Umana, G., Uslenghi, M., Vagelli, V., Vagnetti, F., Valentino, M., Vallania, P., Valore, L., Berg, A. M. Van den, van Driel, W., van Eldik, C., van Soelen, B., Vandenbroucke, J., Vanderwalt, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Vázquez, J. R., Acosta, M. Vázquez, Vecchi, M., Vega, A., Veitch, P., Venault, P., Venter, C., Vercellone, S., Veres, P., Vergani, S., Verzi, V., Vettolani, G. P., Veyssiere, C., Viana, A., Vicha, J., Vigorito, C., Villanueva, J., Vincent, P., Vink, J., Visconti, F., Vittorini, V., Voelk, H., Voisin, V., Vollhardt, A., Vorobiov, S., Vovk, I., Vrastil, M., Vuillaume, T., Wagner, S. J., Wagner, R., Wagner, P., Wakely, S. P., Walstra, T., Walter, R., Ward, M., Ward, J. E., Warren, D., Watson, J. J., Webb, N., Wegner, P., Weiner, O., Weinstein, A., Weniger, C., Werner, F., Wetteskind, H., White, M., White, R., Wierzcholska, A., Wiesand, S., Wijers, R., Wilcox, P., Wilhelm, A., Wilkinson, M., Will, M., Williams, D. A., Winter, M., Wojcik, P., Wolf, D., Wood, M., Wörnlein, A., Wu, T., Yadav, K. K., Yaguna, C., Yamamoto, T., Yamamoto, H., Yamane, N., Yamazaki, R., Yanagita, S., Yang, L., Yelos, D., Yoshida, T., Yoshida, M., Yoshiike, S., Yoshikoshi, T., Yu, P., Zaborov, D., Zacharias, M., Zaharijas, G., Zajczyk, A., Zampieri, L., Zandanel, F., Zanin, R., Sanchez, R. Zanmar, Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., Ziegler, A., Ziemann, J., Ziętara, K., Zink, A., Ziółkowski, J., Zitelli, V., Zoli, A., and Zorn, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

List of contributions from the Cherenkov Telescope Array Consortium presented at the 35th International Cosmic Ray Conference, July 12-20 2017, Busan, Korea., Comment: Index of Cherenkov Telescope Array conference proceedings at the ICRC2017, Busan, Korea

Published
2017

5. Clinical Outcome in Soft Tissue Sarcoma Patients with Lung Metastasis Who Received Metastasectomy and/or Radiofrequency Ablation: Tokai Musculoskeletal Oncology Consortium Study

Author

Nakamura T, Asanuma K, Takao M, Yamanaka T, Koike H, Chen-Yoshikawa TF, Tsukushi S, Kuroda H, Kozawa E, Sano M, Aiba H, Nakanishi R, Nagano A, Yamada K, Shido Y, Kawanami K, Izubuchi Y, Sudo A, and Nishida Y

Subjects
lung metastasis, metastasectomy, radiofrequency ablation, soft tissue sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Tomoki Nakamura,1 Kunihiro Asanuma,1 Motoshi Takao,2 Takashi Yamanaka,3 Hiroshi Koike,4 Toyofumi F Chen-Yoshikawa,5 Satoshi Tsukushi,6 Hiroaki Kuroda,7 Eiji Kozawa,8 Masaaki Sano,9 Hisaki Aiba,10 Ryoichi Nakanishi,11 Akihito Nagano,12 Kenji Yamada,13 Yoji Shido,14 Katsuhisa Kawanami,15 Yuya Izubuchi,16 Akihiro Sudo,1 Yoshihiro Nishida4,17 1Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan; 2Department of Thoracic Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan; 3Department of Radiology, Mie University Graduate School of Medicine, Tsu, Mie, Japan; 4Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; 5Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; 6Department of Orthopedic Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan; 7Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan; 8Department of Orthopedic Surgery, Nagoya Memorial Hospital, Nagoya, Aichi, Japan; 9Department of Thoracic Surgery, Nagoya Memorial Hospital, Nagoya, Aichi, Japan; 10Department of Orthopedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan; 11Department of Oncology, Immunology and Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan; 12Department of Orthopedic Surgery, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan; 13Department of Musculoskeletal Oncology, Okazaki City Hospital, Okazaki, Aichi, Japan; 14Department of Orthopedic Surgery, Hamamatsu Medical University, Hamamatsu, Sizuoka, Japan; 15Department of Orthopedic Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 16Department of Orthopedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Eiheiji, Fukui, Japan; 17Department of Rehabilitation, Nagoya University Hospital, Nagoya, Aichi, JapanCorrespondence: Tomoki NakamuraDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, JapanTel +81592315022Fax +81592315211Email tomoki66@med.mie-u.ac.jpPurpose: Here, we investigated the oncological outcomes of lung metastasectomy and/or radiofrequency ablation (RFA) of 92 patients with soft tissue sarcoma (STS) at nine institutions.Methods: The study cohort included 65 men and 27 women with a mean age of 59 years at the time of metastasis. The mean follow-up duration was 51 months. All patients underwent metastasectomy and/or RFA for lung metastasis.Results: The mean maximum size of the initial lung metastasis was 14.6 mm. At the initial evaluation, 41 patients had a single metastasis, whereas 51 patients had multiple metastases. The mean number of metastasectomies and/or RFA was 2 per patient. A total of 70 patients underwent lung metastasectomy, whereas the other 13 underwent lung RFA. The remaining nine patients underwent both RFA and metastasectomy. The 5-year post-metastatic survival rate was 52%. The patients who underwent complete treatment for the initial metastasis had better post-metastatic survival rates than those who underwent incomplete treatment. A univariate analysis of all possible prognostic factors for complete treatment confirmed the predictive value of disease-free interval, metastasis at initial presentation, distribution, tumor size, and number of lung metastases. Of the 92 patients, 74 underwent complete treatment for initial metastasis; in these patients, univariate and multivariate analyses showed that a smaller tumor size and single-lung metastasis were prognostic factors for superior post-metastatic survival. The patients with a smaller (< 11.5 mm) single metastasis had better post-metastasis survival. The 5-year post-metastatic survival rates were 89.9% for patients with a smaller (< 11.5 mm) single metastasis versus 22.7% for patients with larger (> 11.5 mm) and multiple metastases.Discussion: We propose that complete treatment for lung metastasis in patients with STS may improve post-metastatic survival rates. Furthermore, tumor number and size are important variables for clinical decision-making.Keywords: lung metastasis, metastasectomy, radiofrequency ablation, soft tissue sarcoma

Published
2021

6. Contributions of the Cherenkov Telescope Array (CTA) to the 6th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma 2016)

Author

Consortium, The CTA, Abchiche, A., Abeysekara, U., Abril, Ó., Acero, F., Acharya, B. S., Adams, C., Agnetta, G., Aharonian, F., Akhperjanian, A., Albert, A., Alcubierre, M., Alfaro, J., Alfaro, R., Allafort, A. J., Aloisio, R., Amans, J. -P., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Anderson, J., Anduze, M., Angüner, E. O., Antolini, E., Antonelli, L. A., Antonucci, M., Antonuccio, V., Antoranz, P., Aramo, C., Aravantinos, A., Araya, M., Arcaro, C., Arezki, B., Argan, A., Armstrong, T., Arqueros, F., Arrabito, L., Arrieta, M., Asano, K., Ashley, M., Aubert, P., Singh, C. B., Babic, A., Backes, M., Bais, A., Bajtlik, S., Balazs, C., Balbo, M., Balis, D., Balkowski, C., Ballester, O., Ballet, J., Balzer, A., Bamba, A., Bandiera, R., Barber, A., Barbier, C., Barcelo, M., Barkov, M., Barnacka, A., de Almeida, U. Barres, Barrio, J. A., Basso, S., Bastieri, D., Bauer, C., Becciani, U., Becherini, Y., Tjus, J. Becker, Beckmann, V., Bednarek, W., Benbow, W., Ventura, D. Benedico, Berdugo, J., Berge, D., Bernardini, E., Bernardini, M. G., Bernhard, S., Bernlöhr, K., Bertucci, B., Besel, M. -A., Beshley, V., Bhatt, N., Bhattacharjee, P., Bhattacharyya, W., Bhattachryya, S., Biasuzzi, B., Bicknell, G., Bigongiari, C., Biland, A., Bilinsky, A., Bilnik, W., Biondo, B., Bird, R., Bird, T., Bissaldi, E., Bitossi, M., Blanch, O., Blasi, P., Blazek, J., Bockermann, C., Boehm, C., Bogacz, L., Bogdan, M., Bohacova, M., Boisson, C., Boix, J., Bolmont, J., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonifacio, P., Bonnarel, F., Bonnoli, G., Borkowski, J., Bose, R., Bosnjak, Z., Böttcher, M., Bousquet, J. -J., Boutonnet, C., Bouyjou, F., Bowman, L., Braiding, C., Brantseg, T., Brau-Nogué, S., Bregeon, J., Briggs, M., Brigida, M., Bringmann, T., Brisken, W., Bristow, D., Britto, R., Brocato, E., Bron, S., Brook, P., Brooks, W., Brown, A. M., Brügge, K., Brun, F., Brun, P., Brunetti, G., Brunetti, L., Bruno, P., Buanes, T., Bucciantini, N., Buchholtz, G., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Buson, S., Buss, J., Byrum, K., Cadoux, F., Tovar, J. Calvo, Cameron, R., Canelli, F., Canestrari, R., Capalbi, M., Capasso, M., Capobianco, G., Caproni, A., Caraveo, P., Cardenzana, J., Cardillo, M., Carius, S., Carlile, C., Carosi, A., Carosi, R., Carquín, E., Carr, J., Carroll, M., Carter, J., Carton, P. -H., Casandjian, J. -M., Casanova, S., Cascone, E., Casiraghi, M., Castellina, A., Mora, J. Castroviejo, Catalani, F., Catalano, O., Catalanotti, S., Cauz, D., Cavazzani, S., Cerchiara, P., Chabanne, E., Chadwick, P., Chaleil, T., Champion, C., Chatterjee, A., Chaty, S., Chaves, R., Chen, A., Chen, X., Cheng, K., Chernyakova, M., Chiappetti, L., Chikawa, M., Chinn, D., Chitnis, V. R., Cho, N., Christov, A., Chudoba, J., Cieślar, M., Ciocci, M. A., Clay, R., Colafrancesco, S., Colin, P., Colley, J. -M., Colombo, E., Colome, J., Colonges, S., Conforti, V., Connaughton, V., Connell, S., Conrad, J., Contreras, J. L., Coppi, P., Corbel, S., Coridian, J., Cornat, R., Corona, P., Corti, D., Cortina, J., Cossio, L., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Covone, G., Crimi, G., Criswell, S. J., Crocker, R., Croston, J., Cuadra, J., Cumani, P., Cusumano, G., Da Vela, P., Dale, Ø., D'Ammando, F., Dang, D., Dang, V. T., Dangeon, L., Daniel, M., Davids, I., Dawson, B., Dazzi, F., Costa, B. de Aguiar, De Angelis, A., Cardoso, R. F. de Araujo, De Caprio, V., Anjos, R. de Cássia dos, De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De Lisio, C., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., Neto, J. R. T. de Mello, de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., De Persio, F., de Souza, V., Decock, G., Decock, J., Deil, C., Del Santo, M., Delagnes, E., Deleglise, G., Delgado, C., Delgado, J., della Volpe, D., Deloye, P., Detournay, M., Dettlaff, A., Devin, J., Di Girolamo, T., Di Giulio, C., Di Paola, A., Di Pierro, F., Diaz, M. A., Díaz, C., Dib, C., Dick, J., Dickinson, H., Diebold, S., Digel, S., Dipold, J., Disset, G., Distefano, A., Djannati-Ataï, A., Doert, M., Dohmke, M., Domínguez, A., Dominik, N., Dominique, J. -L., Prester, D. Dominis, Donat, A., Donnarumma, I., Dorner, D., Doro, M., Dournaux, J. -L., Downes, T., Doyle, K., Drake, G., Drappeau, S., Drass, H., Dravins, D., Drury, L., Dubus, G., Ducci, L., Dumas, D., Morå, K. 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Zanmar, Zaric, D., Zavrtanik, D., Zavrtanik, M., Zdziarski, A., Zech, A., Zechlin, H., Zhao, A., Zhdanov, V., Ziegler, A., Ziemann, J., Ziętara, K., Zink, A., Ziółkowski, J., Zitelli, V., Zoli, A., Zorn, J., and Żychowski, P.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

List of contributions from the Cherenkov Telescope Array (CTA) Consortium presented at the 6th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma 2016), July 11-15, 2016, in Heidelberg, Germany., Comment: Index of CTA conference proceedings for the Gamma 2016, Heidelberg, Germany

Published
2016

7. Simple standard equation for daily step count in Japanese patients with chronic obstructive pulmonary disease

Author

Nakanishi M, Minakata Y, Tanaka R, Sugiura H, Kuroda H, Yoshida M, and Yamamoto N

Subjects
COPD, physical activity, behavior modification, goal setting, accelerometer, Diseases of the respiratory system, RC705-779
Abstract

Masanori Nakanishi,1 Yoshiaki Minakata,2 Rie Tanaka,3 Hisatoshi Sugiura,3 Hikaru Kuroda,4 Makoto Yoshida,5 Nobuyuki Yamamoto11Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan; 2Department of Respiratory Medicine, National Hospital Organization Wakayama Hospital, Wakayama, Japan; 3Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; 4Department of Respiratory Medicine, National Hospital Organization Asahikawa Medical Center, Asahikawa, Hokkaido, Japan; 5Department of Respiratory Medicine, National Hospital Organization Fukuoka Hospital, Fukuoka, JapanCorrespondence: Yoshiaki MinakataDepartment of Respiratory Medicine, National Hospital Organization Wakayama Hospital, 1138 Wada Mihama-cho, Hidaka-gun, Wakayama 644-0044, JapanTel +81 73 822 3256Fax +81 73 822 2126Email minakata.yoshiaki.qy@mail.hosp.go.jpPurpose: The improvement of physical activity in patients with COPD is an important issue. However, no standard for the recommended number of steps for patients with COPD has been determined. We conducted a retrospective observational study to create a simple standard equation for the daily step count, which makes it easier to determine whether each subject is attaining his/her predicted value or not.Patients and methods: Stable outpatients diagnosed with COPD whose physical activities had been measured using a triaxial accelerometer for more than 2 weeks were recruited from 5 institutes in Japan. Factors associated with the step count were detected by multivariate regression analysis. After the data were transformed to a normalized distribution, a multivariate linear regression equation was created using stepwise regression.Results: One hundred sixty-two patients aged 72.3 (7.2) years and of FEV1 %pred 59.2 (22.8) % were recruited. Among the parameters, age, mMRC dyspnea scale and inspiratory capacity (IC) were detected by the stepwise method. The created standard equation was “Step count = (−0.079×[age]−1.595×[mMRC]+2.078×[IC]+18.149)3,”. The correlations between the calculated values and the measured values were observed, and fixed, and proportional biases between them were also observed. When patients with

Published
2019

8. Successful postoperative recovery management after thoracoscopic lobectomy and segmentectomy using an ERAS-based protocol of immediate ice cream intake and early ambulation: a 3-year study

Author

Kuroda H, Sugita Y, Watanabe K, Nakanishi K, Sakakura N, Naito Y, and Sakao Y

Subjects
Ice cream, ERAS, Thoracoscopy, Lobectomy, Segmentectomy, chylothorax, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Hiroaki Kuroda,1 Yusuke Sugita,1 Kiyoe Watanabe,2 Keita Nakanishi,1 Noriaki Sakakura,1 Yumiko Naito,2 Yukinori Sakao11Department of Thoracic Surgery; 2Department of Nursing, Aichi Cancer Center Hospital, Nagoya, JapanBackground: Enhanced recovery after surgery (ERAS) protocols are well known for reducing post-operative complications, facilitating early recovery and reducing hospitalization. In this study, we developed ERAS protocols involving immediate ice cream intake for checking postoperative chylothorax and subsequent early ambulation in order to investigate whether these methods have postoperative benefits.Methods: We retrospectively evaluated 500 patients who underwent thoracoscopic segmentectomy and/or lobectomy (TSL) between January 2014 and September 2017. The patients were divided into two groups: 271 patients for Phase I and 229 for Phase II. Ice cream intake commenced during Phase I. Phase I patients were made to walk on the following day, whereas Phase II ambulate within 4 hrs after immediate ice-cream intake.Results: The mean ice cream intake was significantly higher in Phase II than in Phase I (81.6% vs 56.1%). In Phase II, 91.2% and 94.0% were able to ambulate within 4 and 6 hrs, respectively. Minor postoperative complications (Clavien–Dindo I–II classification) were lower in Phase II (3.1%) than in Phase I (10.4%); however, we found no statistical significance (p=0.08). Multivariate analysis showed that ice cream intake and removal of chest drainage tube within 4–6 hrs significantly contributed to the reduction of hospitalization to ≤3 postoperative days (p=0.03 and p

Published
2019

10. Importance of avoiding surgery delays after initial discovery of suspected non-small-cell lung cancer in clinical stage IA patients

Author

Kuroda H, Sugita Y, Ohya Y, Yoshida T, Arimura T, Sakakura N, Hida T, Yatabe Y, and Sakao Y

Subjects
Non-small cell lung cancer, natural history, grand grass opacity, Computed Tomography, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Hiroaki Kuroda,1 Yusuke Sugita,1 Yuko Ohya,2 Tatsuya Yoshida,2 Takaaki Arimura,1 Noriaki Sakakura,1 Toyoaki Hida,2 Yasushi Yatabe,3 Yukinori Sakao1 1Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan; 2Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan; 3Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan Introduction: The natural history of consolidation on computed tomography (CT) rarely includes invasive cancers, and evidence of the ideal timing for surgical intervention via long-term follow-up studies remains unknown. Methods: Between January 2012 and June 2017, pulmonary resection was undertaken in 293 clinical IA patients who were followed-up for > 6 months after the first detection of potential non-small-cell lung cancer (NSCLC) opacities. We evaluated the corresponding HRs and compared the recurrence risk with the CT follow-up duration. Results: HRs calculated for the longest intervals were compared between two patient subsets: a shorter-interval surgery group (SISG: 41.3%; mean follow-up interval, 13.5±5.3 months) and a longer-interval surgery group (58.7%; mean follow-up interval, 54.9±25.6 months). On Cox multivariate regression analyses, CT consolidation (ratio >0.5), an abnormal carcinoembryonic antigen and a triple-negative mutation showed an independent association with an unfavorable prognosis, as measured by disease-free survival after the first detection of potential NSCLC opacities. The longer-interval surgery group fared significantly better than the SISG in terms of 5-year overall survival after the first detection (99.3% vs 93.1%, P

Published
2018

11. Higher frequency of occult lymph node metastasis in clinical N0 pulmonary adenocarcinoma with ALK rearrangement

Author

Seto K, Kuroda H, Yoshida T, Sakata S, Mizuno T, Sakakura N, Hida T, Yatabe Y, and Sakao Y

Subjects
Occult lymph node, pulmonary adenocarcinoma, ALK rearrangement, PET, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Katsutoshi Seto,1 Hiroaki Kuroda,1 Tatsuya Yoshida,2 Shozo Sakata,1 Tetsuya Mizuno,1 Noriaki Sakakura,1 Toyoaki Hida,2 Yasushi Yatabe,3 Yukinori Sakao1 1Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan; 2Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan; 3Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan Objectives: There have been few studies that have fully elucidated the relationship between genomic mutations in pulmonary adenocarcinomas and occult lymph node (LN) metastases (pN1-2) despite a preoperative clinical N0 stage (cN0). It is well known that anaplastic lymphoma kinase (ALK) rearrangements are more likely to occur in younger patients with high grade tumors. The aim of this study was to investigate the genomic status, examine the clinicopathologic features, and evaluate whether ALK mutations are associated with occult LN metastases. Materials and methods: We retrospectively evaluated 459 Japanese patients who underwent pulmonary resection of cN0 adenocarcinomas between January 2012 and December 2015. The clinicopathologic characteristics, including age, sex, smoking index, tumor maximum diameter and consolidation/tumor ratio on computed tomography (CT), maximum standardized uptake value on positron emission tomography (PET) and gene mutations (epidermal growth factor receptor [EGFR], ALK, and kirsten ras genes (KRAS), were evaluated. Results: ALK and EGFR and KRAS mutations were all mutually exclusive. Among 324 patients found to have mutations, ALK was involved in 19 (5.9%), EGFR in 266 (82.1%), and KRAS in 39 (12.0%). The incidence of occult LN metastases did not differ significantly between those with or without mutations (p=0.27). On univariate and multivariate analyses, tumors with ALK were more likely to have occult LN metastases (p=0.03). In cN0 tumors with ALK, pN1 was diagnosed in 26.3% and pN2 in 10.5%, whereas pN1 or pN2 stage was found in

Published
2018

12. Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation

Author

Kuroda, H, Fuentealba, L, Ikeda, A, Reversade, B, and De Robertis, E M

Subjects
neural induction, Smad1, MAPK, FGF, IGF, BMP
Abstract

Xenopus embryonic ectodermal cells dissociated for three or more hours differentiate into neural tissue instead of adopting their normal epidermal fate. This default type of neural induction occurs in the absence of Spemann's organizer signals and is thought to be caused by the dilution of endogenous BMPs into the culture medium. Unexpectedly, we observed that BMP ligands continue to signal in dissociated cells. Instead, cell dissociation induces a sustained activation of the Ras/MAPK pathway, which causes the phosphorylation of Smad1 at sites that inhibit the activity of this transcription factor. It is this activation of Ras/MAPK that is required for neuralization in dissociated ectoderm.

Published
2005

13. Effects of minodronate in postmenopausal women with osteoporosis who received prior treatment with raloxifene

Author

Toda A, Sawada K, Yoshimura A, Nakatsuka E, Kuroda H, Kozasa K, Miyamoto M, Hashimoto K, Mabuchi S, and Kimura T

Subjects
Osteoporosis, Minodronate, Raloxifene, Switching therapy, Gynecology and obstetrics, RG1-991
Abstract

Aska Toda, Kenjiro Sawada, Akihiko Yoshimura, Erika Nakatsuka, Hiromasa Kuroda, Katsumi Kozasa, Mayuko Miyamoto, Kae Hashimoto, Seiji Mabuchi, Tadashi Kimura Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan Background: In clinical practice, patients with postmenopausal osteoporosis have often shown a poor response to treatment with an antiresorptive agent for several years. The purpose of this study was to investigate the efficacy of switching raloxifene with minodronate in patients who responded poorly to the treatment of postmenopausal osteoporosis with raloxifene. Patients and methods: This observational study was conducted based on a single-arm, non-randomized, open-label design and was approved by the institute’s institutional review board. Postmenopausal women with osteoporosis who became unresponsive in terms of bone mineral density (BMD) after being administered raloxifene for two or more years were enrolled. Patients were treated with 1 mg minodronate daily or 50 mg minodronate monthly. Changes in BMD and serum bone turnover markers were monitored at baseline, 6, 12, and 24 months after switching treatment.Results: Twenty-seven patients were enrolled. Two discontinued treatment because of adverse events related to the study drug. Among the remaining 25 patients, lumbar BMD significantly increased by 3.67%, 5.08%, and 6.97% at 6, 12, and 24 months, respectively, and femoral neck BMD increased by 1.63%, 2.18%, and 3.85% at 6, 12, and 24 months, respectively. Serum bone-specific alkaline phosphatase showed a significant reduction of 30.35% from the baseline (p

Published
2017

14. A retrospective study on analgesic requirements for thoracoscopic surgery postoperative pain

Author

Kuroda H, Mizuno H, Dejima H, Watanabe K, Yoshida T, Naito Y, and Sakao Y

Subjects
Tramadol, Thoracoscopic surgery, Ambulation, NRS, Postoperative pain, Medicine (General), R5-920
Abstract

Hiroaki Kuroda,1 Hitomi Mizuno,2 Hitoshi Dejima,1 Kiyoe Watanabe,2 Tatsuya Yoshida,3 Yumiko Naito,2 Yukinori Sakao1 1Department of Thoracic Surgery, 2Department of Nursing, 3Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan Background: Thoracoscopic surgery (TS) has been performed as a minimally invasive procedure since the beginning of the 1990s. This has led to a dramatic change in the postoperative condition of these patients, facilitating early ambulation and easier management of postoperative pain. However, empirical evidence on postoperative pain management after TS is limited. The aims of this study were to determine the efficacy and adequacy of postoperative analgesic medications and to simplify the choice of additional drugs based on a numerical rating scale (NRS).Materials and methods: A retrospective study of patients who underwent TS was performed to evaluate postoperative pain, analgesia requirements, and the number of drugs needed during the perioperative period based on the NRS score.Results: Of the 524 patients, mild pain was noted in 87% patients on the day of the operation and in 75.6% patients on ambulation. The mean NRS score was 1.83±1.49 on the day of the operation and 2.73±1.75 on ambulation. An NRS score of 3 on both the day of operation and on ambulation was defined as the necessary condition for improved pain management. Multivariate analysis showed that high surgical stress significantly influenced pain scores. Reduction in pain with an NRS score of ≥1 was significant with the addition of pentazocine hydrochloride (p3 on ambulation.Conclusion: A small number of patients have moderate-to-severe pain after TS. Tramadol demonstrated borderline efficacy in controlling postoperative intense pain with an NRS score of ≥3. Keywords: tramadol, thoracoscopic surgery, ambulation, NRS, postoperative pain

Published
2017

16. Perioperative Pembrolizumab for Early-Stage Non-Small-Cell Lung Cancer

Author

Heather, W, Moishe, L, Terufumi, K, Masahiro, T, Se-Hoon, L, Shugeng, G, Ke-Neng, C, Christophe, D, Margarita, M, Ekkehard, E, Gastón L, M, Olivier, B, Delvys, R, Jamie E, C, Silvia, N, Jing, Y, Steven M, K, Ayman, S, Spicer, D Marcelo Tatangelo, J, Flores, M, Pastor, A, Puig, J, Martinengo, G, Varela, M, Brocca, C, Wong, M, Hui, R, Dooms, C, Vansteenkiste, J, Demedts, I, Sibille, A, Surmont, V, Deschepper, K, Lambrechts, M, Dias, J, Rafael Martins De Marchi, P, Alves, G, Henrique Araujo, L, Matias, D, Chaves, F, Franke, F, Teixeira, C, Tabacof, J, Faria, L, Morbeck, I, Henrique Cronemberger, E, Lima, I, Sardenberg, R, de Paiva Junior, T, Dutra, C, Luiz Guimaraes, J, Begin, P, Langleben, A, Liu, G, Liberman, M, Spicer, J, Gao, S, Zhao, G, Jiang, T, Yan, X, Hu, J, Chen, J, Tan, L, Wang, Q, Li, S, Chen, K, Yang, Y, Bai, J, Ma, S, Chen, H, Chen, Q, Wang, W, Zhang, L, Zhu, Y, Vanakesa, T, Zasadny, X, Duchemann, B, Girard, N, Bylicki, O, Berard, H, Thiberville, L, Mennecier, B, Mazieres, J, Eigendorff, E, Bonnet, R, Fix, P, Reck, M, Rittmeyer, A, Reinacher-Schick, A, Wehler, T, Lehmann, M, Serke, M, Wesseler, C, Täuscher, D, Lang, S, Wermke, M, Grohe, C, Wirtz, H, Kollmeier, J, Ritgen, M, Mueller, A, Frohling, K, Vogel, G, Faehling, M, Cuffe, S, Collins, D, Delmonte, A, Gilli, M, Piantedosi, F, Ogliari, F, Bulotta, A, Gregorc, V, Gianni, L, Grisanti, S, Intagliata, S, Roca, E, Ferrari, V, Berruti, A, Cortinovis, D, Lo Russo, G, Ferrara, R, Garassino, M, Rita Migliorino, M, Novello, S, Santoro, A, Signorelli, D, Tsuboi, M, Okada, M, Kato, T, Nishio, W, Kuroda, H, Shimizu, J, Sakao, Y, Sugio, K, Horinouchi, H, Takamochi, K, Saji, H, Tanaka, F, Ikeda, N, Muto, S, Shio, Y, Suzuki, H, Hegmane, A, Cicenas, S, Zemaitis, M, Kek Pang, Y, Yew Heng, F, Leong Yu, K, Lowczak, A, Makles, K, Bryl, M, Zurawski, B, Pawlak, I, Han, J, Lee, S, Kim, J, Yong Shim, B, Cebotaru, C, Ganea, D, Scheusan, R, Ciurescu, I, Mazilu, L, Ungureanu, A, Gal, C, Ciubotaru, E, Iordan, I, Berceanu-Ion, R, Ciuleanu, T, Laktionov, K, Karaseva, N, Smagina, M, Luft, A, Afanasyev, S, Nesterova, A, Levchenko, E, Arkhipov, A, Fedenko, A, Ruff, P, Jacobs, C, Fourie, S, Carcereny, E, Calles Blanco, A, Rodriguez Abreu, D, Majem Tarruella, M, Bosch Barrera, J, Bernabe Caro, R, Nadal Alforja, E, Martnez Marti, A, Liao, B, Huang, H, Chiu, C, Wang, C, Tsai, C, Voitko, N, Kryzhanivska, A, Kolesnik, O, Levenko, O, Bondarenko, I, Trukhin, D, Ursol, G, Paramonov, V, Sokur, I, Khan, S, Arora, A, Goranov, B, Greystoke, A, Ahmed, S, Pope, T, O'Brien, M, Charu, V, Cobb, P, Costin, D, Weksler, B, Schumacher, L, Finley, G, Furqan, M, Gentzler, R, Misleh, J, Guarino, M, Halmos, B, Keresztes, R, Jain, K, Yan Lou, Y, Molina, J, Liu-Dumlao, T, Zhao, Q, Niu, J, Taysir Hammoud, Z, Rybkin, I, Cuevo, R, Fernando, H, Schiller, J, Srkalovic, G, Koontz, M, Stampleman, L, Anderson, I, Villaruz, L, Wang, S, Komiya, T, Jain, S, Starodub, A, Wakelee, H, Kishor Ganti, A, Ernani, V, Kristedja, T, O'Day, S, Radhi, S, Sangal, A, Duvivier, H, Rich, P, Kazmi, S, Pollock, T, Chaft, J, Rathnasabapathy, C, Savvides, P, Costas, K, Kaywin, P, Villalona-Calero, M, Alekshun, T, Rao, S, Siegel, R, Wakelee, Heather, Liberman, Moishe, Kato, Terufumi, Tsuboi, Masahiro, Lee, Se-Hoon, Gao, Shugeng, Chen, Ke-Neng, Dooms, Christophe, Majem, Margarita, Eigendorff, Ekkehard, Martinengo, Gastón L, Bylicki, Olivier, Rodríguez-Abreu, Delvys, Chaft, Jamie E, Novello, Silvia, Yang, Jing, Keller, Steven M, Samkari, Ayman, Jonathan D Marcelo Tatangelo, Marcos Flores, Andrea Pastor, Juan Puig, Gaston Martinengo, Mirta Varela, Carlos Brocca, Mark Wong, Rina Hui, Christophe Dooms, Johan Vansteenkiste, Ingel Demedts, Anne Sibille, Veerle Surmont, Koenraad Deschepper, Marc Lambrechts, Josiane Dias, Pedro Rafael Martins De Marchi, Gustavo Alves, Luiz Henrique Araujo, Danielli Matias, Fabio Chaves, Fabio Franke, Carlos Teixeira, Jacques Tabacof, Luiza Faria, Igor Morbeck, Eduardo Henrique Cronemberger, Iane Lima, Rodrigo Sardenberg, Tadeu de Paiva Junior, Carolina Dutra, Jose Luiz Guimaraes, Paul Begin, Adrian Langleben, Geoffrey Liu, Moishe Liberman, Jonathan Spicer, Shugeng Gao, Guofang Zhao, Tao Jiang, Xiaolong Yan, Jian Hu, Jun Chen, Lijie Tan, Qun Wang, Shanqing Li, Keneng Chen, Yue Yang, Jie Bai, Shaohua Ma, Haiquan Chen, Qixun Chen, Wenxiang Wang, Lanjun Zhang, Yuming Zhu, Tonu Vanakesa, Xavier Zasadny, Boris Duchemann, Nicolas Girard, Olivier Bylicki, Henri Berard, Luc Thiberville, Bertrand Mennecier, Julien Mazieres, Ekkehard Eigendorff, Reiner Bonnet, Peter Fix, Martin Reck, Achim Rittmeyer, Anke Reinacher-Schick, Thomas Wehler, Markus Lehmann, Monika Serke, Claas Wesseler, Dagmar Täuscher, Susanne Lang, Martin Wermke, Christian Grohe, Hubert Wirtz, Jens Kollmeier, Mathias Ritgen, Annette Mueller, Klaus-Peter Frohling, Gunther Vogel, Martin Faehling, Sinead Cuffe, Dearbhaile Collins, Angelo Delmonte, Marina Gilli, Francovito Piantedosi, Francesca Ogliari, Alessandra Bulotta, Vanesa Gregorc, Luca Gianni, Salvatore Grisanti, Salvatore Intagliata, Elisa Roca, Vittorio Ferrari, Alfredo Berruti, Diego Cortinovis, Giuseppe Lo Russo, Roberto Ferrara, Marina Garassino, Maria Rita Migliorino, Silvia Novello, Armando Santoro, Diego Signorelli, Masahiro Tsuboi, Morihito Okada, Terufumi Kato, Wataru Nishio, Hiroaki Kuroda, Junichi Shimizu, Yukinori Sakao, Kenji Sugio, Hidehito Horinouchi, Kazuya Takamochi, Hisashi Saji, Fumihiro Tanaka, Norihiko Ikeda, Satoshi Muto, Yutaka Shio, Hiroyuki Suzuki, Alinta Hegmane, Saulius Cicenas, Marius Zemaitis, Yong Kek Pang, Fook Yew Heng, Kong Leong Yu, Anna Lowczak, Krytsyna Makles, Maciej Bryl, Bogdan Zurawski, Ireneusz Pawlak, Ji-Youn Han, Se-Hoon Lee, Jhingook Kim, Byoung Yong Shim, Cristina Cebotaru, Doina Ganea, Roxana Scheusan, Ioana Ciurescu, Laura Mazilu, Andrei Ungureanu, Cristian Gal, Elena Ciubotaru, Ingrid Iordan, Radu Berceanu-Ion, Tudor Ciuleanu, Konstantin Laktionov, Nina Karaseva, Maria Smagina, Alexander Luft, Sergey Afanasyev, Alfiya Nesterova, Evgeny Levchenko, Alexander Arkhipov, Alexander Fedenko, Paul Ruff, Conrad Jacobs, Samuel Fourie, Enric Carcereny, Antonio Calles Blanco, Delvys Rodriguez Abreu, Margarita Majem Tarruella, Joaquim Bosch Barrera, Reyes Bernabe Caro, Ernest Nadal Alforja, Alex Martnez Marti, Bin-Chi Liao, Hsu-Ching Huang, Chao-Hua Chiu, Chin-Chou Wang, Chen-Liang Tsai, Nataliia Voitko, Anna Kryzhanivska, Olena Kolesnik, Oleh Levenko, Oleksii Kolesnik, Igor Bondarenko, Dmytro Trukhin, Grygorii Ursol, Viktor Paramonov, Iryna Sokur, Sarah Khan, Arvind Arora, Bojidar Goranov, Alastair Greystoke, Samreen Ahmed, Tony Pope, Mary O'Brien, Veena Charu, Patrick Cobb, Dan Costin, Benny Weksler, Lana Schumacher, Gene Finley, Muhammad Furqan, Ryan Gentzler, Jamal Misleh, Michael Guarino, Balazs Halmos, Roger Keresztes, Kirti Jain, Yan Yan Lou, Julian Molina, Theresa Liu-Dumlao, Qing Zhao, Jiaxin Niu, Zane Taysir Hammoud, Igor Rybkin, Raymund Cuevo, Hiran Fernando, Joan Schiller, Gordan Srkalovic, Michael Koontz, Laura Stampleman, Ian Anderson, Liza Villaruz, Sarah Wang, Takefumi Komiya, Sushil Jain, Alexander Starodub, Heather Wakelee, Apar Kishor Ganti, Vinicius Ernani, Timothy Kristedja, Steven O'Day, Saba Radhi, Ashish Sangal, Herbert Duvivier, Patricia Rich, Shayma Kazmi, Theodore Pollock, Jamie Chaft, Chenthilmurugan Rathnasabapathy, Panayiotis Savvides, Kimberly Costas, Paul Kaywin, Miguel Villalona-Calero, Todd Alekshun, Kevin Chen, Suman Rao, Robert Siegel, Heather, W, Moishe, L, Terufumi, K, Masahiro, T, Se-Hoon, L, Shugeng, G, Ke-Neng, C, Christophe, D, Margarita, M, Ekkehard, E, Gastón L, M, Olivier, B, Delvys, R, Jamie E, C, Silvia, N, Jing, Y, Steven M, K, Ayman, S, Spicer, D Marcelo Tatangelo, J, Flores, M, Pastor, A, Puig, J, Martinengo, G, Varela, M, Brocca, C, Wong, M, Hui, R, Dooms, C, Vansteenkiste, J, Demedts, I, Sibille, A, Surmont, V, Deschepper, K, Lambrechts, M, Dias, J, Rafael Martins De Marchi, P, Alves, G, Henrique Araujo, L, Matias, D, Chaves, F, Franke, F, Teixeira, C, Tabacof, J, Faria, L, Morbeck, I, Henrique Cronemberger, E, Lima, I, Sardenberg, R, de Paiva Junior, T, Dutra, C, Luiz Guimaraes, J, Begin, P, Langleben, A, Liu, G, Liberman, M, Spicer, J, Gao, S, Zhao, G, Jiang, T, Yan, X, Hu, J, Chen, J, Tan, L, Wang, Q, Li, S, Chen, K, Yang, Y, Bai, J, Ma, S, Chen, H, Chen, Q, Wang, W, Zhang, L, Zhu, Y, Vanakesa, T, Zasadny, X, Duchemann, B, Girard, N, Bylicki, O, Berard, H, Thiberville, L, Mennecier, B, Mazieres, J, Eigendorff, E, Bonnet, R, Fix, P, Reck, M, Rittmeyer, A, Reinacher-Schick, A, Wehler, T, Lehmann, M, Serke, M, Wesseler, C, Täuscher, D, Lang, S, Wermke, M, Grohe, C, Wirtz, H, Kollmeier, J, Ritgen, M, Mueller, A, Frohling, K, Vogel, G, Faehling, M, Cuffe, S, Collins, D, Delmonte, A, Gilli, M, Piantedosi, F, Ogliari, F, Bulotta, A, Gregorc, V, Gianni, L, Grisanti, S, Intagliata, S, Roca, E, Ferrari, V, Berruti, A, Cortinovis, D, Lo Russo, G, Ferrara, R, Garassino, M, Rita Migliorino, M, Novello, S, Santoro, A, Signorelli, D, Tsuboi, M, Okada, M, Kato, T, Nishio, W, Kuroda, H, Shimizu, J, Sakao, Y, Sugio, K, Horinouchi, H, Takamochi, K, Saji, H, Tanaka, F, Ikeda, N, Muto, S, Shio, Y, Suzuki, H, Hegmane, A, Cicenas, S, Zemaitis, M, Kek Pang, Y, Yew Heng, F, Leong Yu, K, Lowczak, A, Makles, K, Bryl, M, Zurawski, B, Pawlak, I, Han, J, Lee, S, Kim, J, Yong Shim, B, Cebotaru, C, Ganea, D, Scheusan, R, Ciurescu, I, Mazilu, L, Ungureanu, A, Gal, C, Ciubotaru, E, Iordan, I, Berceanu-Ion, R, Ciuleanu, T, Laktionov, K, Karaseva, N, Smagina, M, Luft, A, Afanasyev, S, Nesterova, A, Levchenko, E, Arkhipov, A, Fedenko, A, Ruff, P, Jacobs, C, Fourie, S, Carcereny, E, Calles Blanco, A, Rodriguez Abreu, D, Majem Tarruella, M, Bosch Barrera, J, Bernabe Caro, R, Nadal Alforja, E, Martnez Marti, A, Liao, B, Huang, H, Chiu, C, Wang, C, Tsai, C, Voitko, N, Kryzhanivska, A, Kolesnik, O, Levenko, O, Bondarenko, I, Trukhin, D, Ursol, G, Paramonov, V, Sokur, I, Khan, S, Arora, A, Goranov, B, Greystoke, A, Ahmed, S, Pope, T, O'Brien, M, Charu, V, Cobb, P, Costin, D, Weksler, B, Schumacher, L, Finley, G, Furqan, M, Gentzler, R, Misleh, J, Guarino, M, Halmos, B, Keresztes, R, Jain, K, Yan Lou, Y, Molina, J, Liu-Dumlao, T, Zhao, Q, Niu, J, Taysir Hammoud, Z, Rybkin, I, Cuevo, R, Fernando, H, Schiller, J, Srkalovic, G, Koontz, M, Stampleman, L, Anderson, I, Villaruz, L, Wang, S, Komiya, T, Jain, S, Starodub, A, Wakelee, H, Kishor Ganti, A, Ernani, V, Kristedja, T, O'Day, S, Radhi, S, Sangal, A, Duvivier, H, Rich, P, Kazmi, S, Pollock, T, Chaft, J, Rathnasabapathy, C, Savvides, P, Costas, K, Kaywin, P, Villalona-Calero, M, Alekshun, T, Rao, S, Siegel, R, Wakelee, Heather, Liberman, Moishe, Kato, Terufumi, Tsuboi, Masahiro, Lee, Se-Hoon, Gao, Shugeng, Chen, Ke-Neng, Dooms, Christophe, Majem, Margarita, Eigendorff, Ekkehard, Martinengo, Gastón L, Bylicki, Olivier, Rodríguez-Abreu, Delvys, Chaft, Jamie E, Novello, Silvia, Yang, Jing, Keller, Steven M, Samkari, Ayman, Jonathan D Marcelo Tatangelo, Marcos Flores, Andrea Pastor, Juan Puig, Gaston Martinengo, Mirta Varela, Carlos Brocca, Mark Wong, Rina Hui, Christophe Dooms, Johan Vansteenkiste, Ingel Demedts, Anne Sibille, Veerle Surmont, Koenraad Deschepper, Marc Lambrechts, Josiane Dias, Pedro Rafael Martins De Marchi, Gustavo Alves, Luiz Henrique Araujo, Danielli Matias, Fabio Chaves, Fabio Franke, Carlos Teixeira, Jacques Tabacof, Luiza Faria, Igor Morbeck, Eduardo Henrique Cronemberger, Iane Lima, Rodrigo Sardenberg, Tadeu de Paiva Junior, Carolina Dutra, Jose Luiz Guimaraes, Paul Begin, Adrian Langleben, Geoffrey Liu, Moishe Liberman, Jonathan Spicer, Shugeng Gao, Guofang Zhao, Tao Jiang, Xiaolong Yan, Jian Hu, Jun Chen, Lijie Tan, Qun Wang, Shanqing Li, Keneng Chen, Yue Yang, Jie Bai, Shaohua Ma, Haiquan Chen, Qixun Chen, Wenxiang Wang, Lanjun Zhang, Yuming Zhu, Tonu Vanakesa, Xavier Zasadny, Boris Duchemann, Nicolas Girard, Olivier Bylicki, Henri Berard, Luc Thiberville, Bertrand Mennecier, Julien Mazieres, Ekkehard Eigendorff, Reiner Bonnet, Peter Fix, Martin Reck, Achim Rittmeyer, Anke Reinacher-Schick, Thomas Wehler, Markus Lehmann, Monika Serke, Claas Wesseler, Dagmar Täuscher, Susanne Lang, Martin Wermke, Christian Grohe, Hubert Wirtz, Jens Kollmeier, Mathias Ritgen, Annette Mueller, Klaus-Peter Frohling, Gunther Vogel, Martin Faehling, Sinead Cuffe, Dearbhaile Collins, Angelo Delmonte, Marina Gilli, Francovito Piantedosi, Francesca Ogliari, Alessandra Bulotta, Vanesa Gregorc, Luca Gianni, Salvatore Grisanti, Salvatore Intagliata, Elisa Roca, Vittorio Ferrari, Alfredo Berruti, Diego Cortinovis, Giuseppe Lo Russo, Roberto Ferrara, Marina Garassino, Maria Rita Migliorino, Silvia Novello, Armando Santoro, Diego Signorelli, Masahiro Tsuboi, Morihito Okada, Terufumi Kato, Wataru Nishio, Hiroaki Kuroda, Junichi Shimizu, Yukinori Sakao, Kenji Sugio, Hidehito Horinouchi, Kazuya Takamochi, Hisashi Saji, Fumihiro Tanaka, Norihiko Ikeda, Satoshi Muto, Yutaka Shio, Hiroyuki Suzuki, Alinta Hegmane, Saulius Cicenas, Marius Zemaitis, Yong Kek Pang, Fook Yew Heng, Kong Leong Yu, Anna Lowczak, Krytsyna Makles, Maciej Bryl, Bogdan Zurawski, Ireneusz Pawlak, Ji-Youn Han, Se-Hoon Lee, Jhingook Kim, Byoung Yong Shim, Cristina Cebotaru, Doina Ganea, Roxana Scheusan, Ioana Ciurescu, Laura Mazilu, Andrei Ungureanu, Cristian Gal, Elena Ciubotaru, Ingrid Iordan, Radu Berceanu-Ion, Tudor Ciuleanu, Konstantin Laktionov, Nina Karaseva, Maria Smagina, Alexander Luft, Sergey Afanasyev, Alfiya Nesterova, Evgeny Levchenko, Alexander Arkhipov, Alexander Fedenko, Paul Ruff, Conrad Jacobs, Samuel Fourie, Enric Carcereny, Antonio Calles Blanco, Delvys Rodriguez Abreu, Margarita Majem Tarruella, Joaquim Bosch Barrera, Reyes Bernabe Caro, Ernest Nadal Alforja, Alex Martnez Marti, Bin-Chi Liao, Hsu-Ching Huang, Chao-Hua Chiu, Chin-Chou Wang, Chen-Liang Tsai, Nataliia Voitko, Anna Kryzhanivska, Olena Kolesnik, Oleh Levenko, Oleksii Kolesnik, Igor Bondarenko, Dmytro Trukhin, Grygorii Ursol, Viktor Paramonov, Iryna Sokur, Sarah Khan, Arvind Arora, Bojidar Goranov, Alastair Greystoke, Samreen Ahmed, Tony Pope, Mary O'Brien, Veena Charu, Patrick Cobb, Dan Costin, Benny Weksler, Lana Schumacher, Gene Finley, Muhammad Furqan, Ryan Gentzler, Jamal Misleh, Michael Guarino, Balazs Halmos, Roger Keresztes, Kirti Jain, Yan Yan Lou, Julian Molina, Theresa Liu-Dumlao, Qing Zhao, Jiaxin Niu, Zane Taysir Hammoud, Igor Rybkin, Raymund Cuevo, Hiran Fernando, Joan Schiller, Gordan Srkalovic, Michael Koontz, Laura Stampleman, Ian Anderson, Liza Villaruz, Sarah Wang, Takefumi Komiya, Sushil Jain, Alexander Starodub, Heather Wakelee, Apar Kishor Ganti, Vinicius Ernani, Timothy Kristedja, Steven O'Day, Saba Radhi, Ashish Sangal, Herbert Duvivier, Patricia Rich, Shayma Kazmi, Theodore Pollock, Jamie Chaft, Chenthilmurugan Rathnasabapathy, Panayiotis Savvides, Kimberly Costas, Paul Kaywin, Miguel Villalona-Calero, Todd Alekshun, Kevin Chen, Suman Rao, and Robert Siegel

Abstract

BACKGROUND Among patients with resectable early-stage non-small-cell lung cancer (NSCLC), a perioperative approach that includes both neoadjuvant and adjuvant immune checkpoint inhibition may provide benefit beyond either approach alone. METHODS We conducted a randomized, double-blind, phase 3 trial to evaluate perioperative pembrolizumab in patients with early-stage NSCLC. Participants with resectable stage II, IIIA, or IIIB (N2 stage) NSCLC were assigned in a 1:1 ratio to receive neoadjuvant pembrolizumab (200 mg) or placebo once every 3 weeks, each of which was given with cisplatin-based chemotherapy for 4 cycles, followed by surgery and adjuvant pembrolizumab (200 mg) or placebo once every 3 weeks for up to 13 cycles. The dual primary end points were event-free survival (the time from randomization to the first occurrence of local progression that precluded the planned surgery, unresectable tumor, progression or recurrence, or death) and overall survival. Secondary end points included major pathological response, pathological complete response, and safety. RESULTS A total of 397 participants were assigned to the pembrolizumab group, and 400 to the placebo group. At the prespecified first interim analysis, the median follow-up was 25.2 months. Event-free survival at 24 months was 62.4% in the pembrolizumab group and 40.6% in the placebo group (hazard ratio for progression, recurrence, or death, 0.58; 95% confidence interval [CI], 0.46 to 0.72; P<0.001). The estimated 24-month overall survival was 80.9% in the pembrolizumab group and 77.6% in the placebo group (P = 0.02, which did not meet the significance criterion). A major pathological response occurred in 30.2% of the participants in the pembrolizumab group and in 11.0% of those in the placebo group (difference, 19.2 percentage points; 95% CI, 13.9 to 24.7; P<0.0001; threshold, P = 0.0001), and a pathological complete response occurred in 18.1% and 4.0%, respectively (difference, 14.2 percentage points

Published
2023

22. High-order Harmonic Generation from the Laser Plasma Produced on the Surface of Solid Targets

Author

Ganeev, R. A., Suzuki, M., Baba, M., Kuroda, H., Rhodes, William T., editor, Adibi, Ali, editor, Asakura, Toshimitsu, editor, Hänsch, Theodor W., editor, Kamiya, Takeshi, editor, Krausz, Ferenc, editor, Monemar, Bo, editor, Venghaus, Herbert, editor, Weber, Horst, editor, Weinfurter, Harald, editor, Watanabe, Shuntaro, editor, and Midorikawa, Katsumi, editor

Published
2007
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25. 955P Association of skeletal muscle mass with safety and efficacy of atezolizumab (atezo) plus bevacizumab (bev) in Japanese patients (pts) with unresectable hepatocellular carcinoma (uHCC): Results from the ELIXIR study

Author

Hiraoka, A., Aikata, H., Moriguchi, M., Ikeda, M., Morimoto, N., Tsuchiya, K., Takehara, T., Nagai, H., Sakamori, R., Nakamura, S., Tsuji, K., Kuroda, H., Shimizu, M., Shiina, S., Yamasaki, T., Kudo, M., Kokudo, N., Furuse, J., Yamamoto, K., and Yamashita, T.

Published
2024
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26. Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity

Author

Ohyama, S, Ouchi, T, Kimura, M, Kurashima, R, Yasumatsu, K, Nishida, D, Hitomi, S, Ubaidus, S, Kuroda, H, Ito, S, Takano, M, Ono, K, Mizoguchi, T, Katakura, A, Shibukawa, Y, Ohyama, S, Ouchi, T, Kimura, M, Kurashima, R, Yasumatsu, K, Nishida, D, Hitomi, S, Ubaidus, S, Kuroda, H, Ito, S, Takano, M, Ono, K, Mizoguchi, T, Katakura, A, and Shibukawa, Y

Abstract

©2022 Ohyama, Ouchi, Kimura, Kurashima, Yasumatsu, Nishida, Hitomi, Ubaidus, Kuroda, Ito, Takano, Ono, Mizoguchi, Katakura and Shibukawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Published
2022

46. Fundamental Study on Open Fault Detection Technology of Bypass Circuit of PV Module with IR Camera

Author

Nishikawa, S., Fujita, N., and Kuroda, H.

Subjects
PV Module Design, Manufacture, Performance and Reliability, Photovoltaic Modules and BoS Components
Abstract

37th European Photovoltaic Solar Energy Conference and Exhibition; 914-918, When a bypass circuit of PV module is open and performance of solar cells drop by partial shadow, abnormality, and so on, the temperature of those cells increase and become hotspot. Observation of module surface temperature with IR camera is very popular technology for finding hotspot. However, a hotspot does not occur with only existence of open fault of bypass circuit, and temperature does not increase under low irradiance. In our proposed technology, the pseudo sine-wave voltage with DC bias is applied across the PV string. The temperature of the faulty part without bypass circuit changes in accordance with change of applying voltage. The temperature change is observed with an IR camera, and only the fault position is identified by the frequency analysis of temperature change. However, temperature change is influenced by mainly magnitudes of irradiance and applied voltage. To clear their effect, we conducted a fundamental test by using a small string with a dummy open fault of bypass circuit. As a result, when irradiance is more than 200W/m2 and applied voltage across a string is bigger than open circuit voltage Voc of a PV module, we can find an open fault position in a string.

Published
2020
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