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34 results on '"Kuroda, Tomoko"'

10. Preimplantation Genetic Testing for Aneuploidy for Recurrent Pregnancy Loss and Recurrent Implantation Failure in Minimal Ovarian Stimulation Cycle for Women Aged 35–42 Years: Live Birth Rate, Developmental Follow-up of Children, and Embryo Ranking

Author

Kato, Keiichi, primary, Kuroda, Tomoko, additional, Yamadera-Egawa, Rie, additional, Ezoe, Kenji, additional, Aoyama, Naoki, additional, Usami, Akemi, additional, Miki, Tetsuya, additional, Yamamoto, Toshiyuki, additional, and Takeshita, Toshiyuki, additional

Published
2022
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14. Preimplantation genetic testing using comprehensive genomic copy number analysis is beneficial for balanced translocation carriers

Author

Yamazaki, Aya, Kuroda, Tomoko, Kawasaki, Nami, Kato, Keiichi, Shimojima Yamamoto, Keiko, Iwasa, Takeshi, Kuwahara, Akira, Taniguchi, Yuka, Takeshita, Toshiyuki, Kita, Yosuke, Mikami, Mikio, Irahara, Minoru, and Yamamoto, Toshiyuki

Abstract

Balanced chromosomal translocation is one of chromosomal variations. Carriers of balanced chromosomal translocations have an increased risk of spontaneous miscarriage. To avoid the risk, preimplantation genetic testing (PGT) using comprehensive genomic copy number analysis has been developed. This study aimed to verify whether and how embryos from couples in which one partner is a balanced translocation carrier have a higher ratio of chromosomal abnormalities. A total of 894 biopsied trophectoderms (TEs) were obtained from 130 couples in which one partner was a balanced translocation carrier (Robertsonian translocation, reciprocal translocation, or intrachromosomal inversion) and grouped as PGT-SR. Conversely, 3269 TEs from 697 couples who experienced recurrent implantation failure or recurrent pregnancy loss were included in the PGT-A group. The transferable blastocyst ratio was significantly lower in the PGT-SR group, even when bias related to the sample number and patient age was corrected. Subgroup analysis of the PGT-SR group revealed that the transferable blastocyst ratio was higher in the Robertsonian translocation group. Because the PGT-SR group had a higher proportion of untransferable embryos than the PGT-A group, PGT using comprehensive genomic copy number analysis was more beneficial for balanced translocation carriers than for infertility patients without chromosomal translocations. The frequencies of de novo aneuploidies were further analyzed, and the frequency in the PGT-SR group was lower than that in the PGT-A group. Therefore, we could not confirm the existence of interchromosomal effects in this study.

Published
2023
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16. Preimplantation genetic testing for aneuploidy: a comparison of live birth rates in patients with recurrent pregnancy loss due to embryonic aneuploidy or recurrent implantation failure

Author

Sato, Takeshi, primary, Sugiura-Ogasawara, Mayumi, additional, Ozawa, Fumiko, additional, Yamamoto, Toshiyuki, additional, Kato, Takema, additional, Kurahashi, Hiroki, additional, Kuroda, Tomoko, additional, Aoyama, Naoki, additional, Kato, Keiichi, additional, Kobayashi, Ryota, additional, Fukuda, Aisaku, additional, Utsunomiya, Takafumi, additional, Kuwahara, Akira, additional, Saito, Hidekazu, additional, Takeshita, Toshiyuki, additional, and Irahara, Minoru, additional

Published
2020
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17. Preimplantation genetic testing for aneuploidy: a comparison of live birth rates in patients with recurrent pregnancy loss due to embryonic aneuploidy or recurrent implantation failure

Author

Sato, Takeshi, primary, Sugiura-Ogasawara, Mayumi, additional, Ozawa, Fumiko, additional, Yamamoto, Toshiyuki, additional, Kato, Takema, additional, Kurahashi, Hiroki, additional, Kuroda, Tomoko, additional, Aoyama, Naoki, additional, Kato, Keiichi, additional, Kobayashi, Ryota, additional, Fukuda, Aisaku, additional, Utsunomiya, Takafumi, additional, Kuwahara, Akira, additional, Saito, Hidekazu, additional, Takeshita, Toshiyuki, additional, and Irahara, Minoru, additional

Published
2019
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24. Synthesis and Biological Evaluationof CyclopentaquinolineDerivatives as Nonsteroidal Glucocorticoid Receptor Antagonists.

Author

Eda, Masahiro, Kuroda, Tomoko, Kaneko, Satoshi, Aoki, Yoshiyuki, Yamashita, Masami, Okumura, Chieko, Ikeda, Yoshitaka, Ohbora, Tomoko, Sakaue, Masaki, Koyama, Natsumi, and Aritomo, Keiichi

Subjects
*QUINOLINE derivatives, *AROMATIC compound synthesis, *GLUCOCORTICOID receptors, *MIFEPRISTONE, *THERAPEUTICS, *MENTAL depression, *DRUG development, *STEROID receptors
Abstract

The steroidal glucocorticoid antagonistmifepristone has been reportedto improve the symptoms of depression. We report the discovery of6-(3,5-dimethylisoxazol-4-yl)-2,2,4,4-tetramethyl-2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]quinolin-3-one 3d(QCA-1093)as a novel nonsteroidal glucocorticoid receptor antagonist. The compounddisplayed potent in vitroactivity, high selectivityover other steroid hormone receptors, and significant antidepressant-likeactivity in vivo. [ABSTRACT FROM AUTHOR]

Published
2015
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27. Reproductive outcomes following preimplantation genetic diagnosis using fluorescence in situhybridization for 52 translocation carrier couples with a history of recurrent pregnancy loss

Author

Kato, Keiichi, Aoyama, Naoki, Kawasaki, Nami, Hayashi, Hiroko, Xiaohui, Tang, Abe, Takashi, and Kuroda, Tomoko

Abstract

Forty-six reciprocal and six Robertsonian translocation carrier couples who experienced recurrent pregnancy loss underwent fluorescence in situhybridization-based preimplantation genetic diagnosis (PGD) for the presence of the two translocated chromosomes. Out of 52 couples, 17 (33%) were undergoing infertility treatment. In total, 239 PGD cycles as oocyte retrieval (OR) were applied. The transferrable rate of negatively diagnosed embryos at the cleavage stage was 26.3%; 71 embryos were transferred as single blastocysts. The clinical pregnancy rate per transfer was 60.6%. We obtained 41 healthy live births with 3 incidences of miscarriage (7.0%). The average cumulative live birth rate was 76.9% during 4.6 OR cycles using a mild ovarian stimulation strategy. The outcomes were classified into four groups based on carrier gender and maternal age (young (<38 years) or advanced). PGD was performed for 52 couples of which the average number of OR cycles was 4.1, 2.1, 6.7 and 4.5 in young female and male carriers and female and male carriers of advanced age; the live birth rate for a primiparity was 77.8, 72.7, 66.7 and 50.0% in those groups. These results suggest that the final live birth rate might be influenced by maternal age regardless of the gender of the carrier.

Published
2016
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34. Neonatal outcome and birth defects in 6623 singletons born following minimal ovarian stimulation and vitrified versus fresh single embryo transfer.

Author

Kato O, Kawasaki N, Bodri D, Kuroda T, Kawachiya S, Kato K, and Takehara Y

Subjects
Adult, Birth Weight, Congenital Abnormalities epidemiology, Congenital Abnormalities etiology, Female, Fertilization in Vitro, Gestational Age, Humans, Infant, Low Birth Weight, Infant, Newborn, Japan epidemiology, Middle Aged, Perinatal Mortality, Pregnancy, Retrospective Studies, Embryo Transfer statistics & numerical data, Ovulation Induction methods, Pregnancy Outcome, Single Embryo Transfer, Vitrification
Abstract

Objective: To compare neonatal outcome between children born after vitrified versus fresh single-embryo transfer (SET)., Study Design: Retrospective, single-centre cohort study of 6623 delivered singletons following 29,944 single-embryo transfers. Patients underwent minimal ovarian stimulation/natural cycle IVF followed by SET of fresh or vitrified-warmed (using Cryotop, Kitazato) cleavage-stage embryos or blastocysts. Outcome measures were gestational age at delivery, birth weight, birth length, low birth weight (LBW), small for gestational age (SGA) and large for gestational age (LGA) infants, perinatal mortality and minor/major birth defects (evaluated by parent questionnaire)., Results: Gestational age (38.6 ± 2 versus 38.7 ± 1.9 weeks) and preterm delivery rate (6.9% versus 6.9%, aOR: 0.96 95%CI: 0.76-1.22) in singletons born after the transfer of vitrified embryos were comparable to those born after the transfer of fresh embryos. Children born after the transfer of vitrified embryos had a higher birth weight (3028 ± 465 versus 2943 ± 470 g, p<0.0001) and lower LBW (8.5% versus 11.9%, aOR: 0.65 95%CI: 0.53-0.79) and SGA (3.6% versus 7.6% aOR: 0.43 95%CI: 0.33-0.56) rates. Total birth defect rates (including minor anomalies) (2.4% versus 1.9%, aOR: 1.41 95%CI: 0.96-2.10) and perinatal mortality rates (0.6% versus 0.5%, aOR: 1.02 95%CI: 0.21-4.85) were comparable between the vitrified and fresh groups., Conclusions: Vitrification of embryos/blastocysts did not increase the incidence of adverse neonatal outcomes or birth defects following single embryo transfer., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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