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10. P4669The advantage of echocardiographic RV wall thickness over ECG criteria of RVH for detection of confirmed pulmonary hypertension

Author

Wierzbowska-Drabik, K, primary, Gargani, L, additional, Cieslik-Guerra, U, additional, Kurpesa, M, additional, Uznanska-Loch, B, additional, Sobczak, M, additional, Trzos, E, additional, Szymczyk, E, additional, Rechcinski, T, additional, Nowak, B, additional, Nowakowski, R, additional, and Kasprzak, J, additional

Published
2018
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11. 340 Myocardial infarction and return to work

Author

Gadzicka, E, primary, Siedlecka, J, additional, Makowiec- Dąbrowska, T, additional, Viebig, P, additional, Szyjkowska, A, additional, Wranicz, K, additional, Trzos, E, additional, Kurpesa, M, additional, Szymczak, W, additional, and Bortkiewicz, A, additional

Published
2018
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14. A prospective survey in European Society of Cardiology member countries of atrial fibrillation management:baseline results of EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot General Registry

Author

Lip, G. Y. H., Laroche, C., Dan, G. -A., Santini, M., Kalarus, Z., Rasmussen, L. H., Oliveira, M. M., Mairesse, G., Crijns, H. J. G. M., Simantirakis, E., Atar, D., Kirchhof, P., Vardas, P., Tavazzi, L., Maggioni, A. P., Raepers, M., El Husseini, Z., Dilling-Boer, D., Schurmans, J., Vijgen, J., Koopman, P., Huybrechts, W., Dormal, F., Blommaert, D., Deceuninck, O., Xhaet, O., Fragtrup Hellum, C., Mortensen, B., Ginnerup Sorensen, B., Joensen, A. M., Karlsdottir, A., Pehrson, S., Hummelshoj, J., Svenningsen, A-M., Tanggaard, L., Wiggers, P., Nygaard, A., Jonstrup, A., Petersen, J., Odgaard, A., Mortensen, M., Frost, L., Svenstrup Moller, D., Sondergaard, H. M., Christensen, P. D., Xydonas, S., Lioni, L., Dimopoulou, M., Georgiopoulos, G., Papatheodorou, E., Boutas, P., Kartalis, A., Nakou, H., Kanoupakis, E., Tahmatzidis, D., Styliadis, I., Vassilikos, V., Koskinas, K., Fragakis, N., Polymeropoulos, K., Maligos, G., Martignani, C., Diemberger, I., Boriani, G., Frisoni, J., Biffi, M., Ziacchi, M., Cimaglia, P., Fantecchi, E., Boni, S., Gabbai, D., Marchionni, N., Fumagalli, S., Bobbo, M., Ramani, F., Sinagra, G., Vitali-Serdoz, L., Nordio, A., Porto, A., Zecchin, M., Di Nora, C., Novo, S., Guarneri, F. P., Macaione, F., Rod, R., Stodle, R. M. O., Pervez, M. O., Smith, P., Buvarp, M., Ronnevik, P. K., Vold, A., Fuglestved, J., Stenshjemmet, E., Risberg, K., Sokal, A., Kubicius, A., Prochniewicz, E., Pokrywa, K., Rzeuski, R., Weryszko, A., Haberka, M., Gasior, Z., Slowikowski, A., Janion, M., Kolodziej, M., Janion-Sadowska, A., Drozdz, J., Stasiak, M., Jakubowski, P., Ciurus, T., Pawlak, M., Nowakowska, M., Wiklo, K., Kurpesa, M., Olejnik, A., Miarka, J., Streb, W., Zielinski, L., Dluzniewski, M., Tomaszewska-Kiecana, M., Opolski, G., Budnik, M., Kiliszek, M., Gorska, J., Mamcarz, A., Sliz, D., Makowiecki, K., Fuglewicz, A., Drozd, M., Garncarek, M., Musialik-Lydka, A., Markowicz-Pawlus, E., Kazmierczak, G., Leopold-Jadczyk, A., Koziel, M., Sobral, S., Pereira, H., Brandao Alves, L., Ribeiro, L., Miranda, R., Almeida, S., Madeira, F., Faustino, M., Oliveira, R., Gil, V., Braga, C., Martins, J., Rocha, S., Magalhaes, S., Ramos, V., Bernardo, R., Costa, F., Morgado, F., Galvao Santos, P., Almeida, N., Adragao, P., Carmo, P., Mariano Pego, G., Ferreira, J., Elvas, L., Ventura, M., Antonio, N., Ferreira, R., Damasio, A. F., Santos, A. R., Picarra, B., Neves, D., De Jesus, I., Amado, J., Sousa, P., Candeias, R., Lourenco, A., Pereira, A., Canario-Almeida, F., Fernandes, M., Ferreira, F., Machado, I., Quelhas, I., Guardado, J., Pereira, V., Cavaco, D., Lousinha, A., Valente, B., Silva, N., Cunha, P., Pimenta, R., Santos, S., Martins Oliveira, M., Vicente, S., Bernardes, A., Nunes Diogo, A., Rodrigues, E., Frazao Rodrigues De Sousa, J. M., Carpinteiro, L., Satendra, M., Cortez Dias, N., Neto, S., Gama Ribeiro, V., Goncalves, H., Primo, J., Adao, L., Oliveira, M., Costa, A., Delgado, A., Marmelo, B., Moreira, D., Santos, J., Santos, L., Rodrigues, B., Pop Moldovan, A., Darabantiu, D., Todea, B., Pop, C., Dicu, D., Filip, D., Mercea, D., Kozma, G., Schiopu, M., Catanescu, G., Popescu, C., Bobescu, E., Gabor, A., Buzea, A., Dan, A., Buzea Daha, I., Asan, N., Popescu, R., Bartos, D., Badila, E., Tintea, E., Grigore, C., Daraban, A. M., Sandulescu, A., Carp, A., Gherasim, D., Stoian, I. M., Baluta, M. M., Vintila, M. M., Popescu, M. I., Tica, O., Petrescu, L., Alina-Ramona, N., Dan, R., Cozma, D. C., Tutuianu, C., Mangea, M., Goanta, E., Van Opstal, J. M., Van Rennes, R., Mulder, B. A., Said, S. A. M., Folkeringa, R. J., Philippens, S., Blaauw, Y., Aksoy, I., Pluymen, M., Driessen, R., Limantoro, I., Lankveld, T., Mafi Rad, M., Hendriks, J., Van Unen, W. H., Meeder, J., Cardiologie, MUMC+: MA Cardiologie (9), and RS: CARIM - R2 - Cardiac function and failure

Subjects
Male, medicine.medical_specialty, Registry, Digoxin, medicine.medical_treatment, Physician's Practice Patterns, Administration, Oral, Pilot Projects, Comorbidity, Antiarrhythmic agent, Amiodarone, Anticoagulation, Fibrinolytic Agents, Atrial fibrillation, Risk scores, Risk Factors, Physiology (medical), Internal medicine, Antithrombotic, Atrial Fibrillation, medicine, Prevalence, Humans, Registries, Practice Patterns, Physicians', business.industry, Anticoagulants, Thrombosis, medicine.disease, Causality, Europe, Treatment Outcome, Health Care Surveys, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Anti-Arrhythmia Agents, Fibrinolytic agent, medicine.drug
Abstract

AIMS: Given the advances in atrial fibrillation (AF) management and the availability of new European Society of Cardiology (ESC) guidelines, there is a need for the systematic collection of contemporary data regarding the management and treatment of AF in ESC member countries.METHODS AND RESULTS: We conducted a registry of consecutive in- and outpatients with AF presenting to cardiologists in nine participating ESC countries. All patients with an ECG-documented diagnosis of AF confirmed in the year prior to enrolment were eligible. We enroled a total of 3119 patients from February 2012 to March 2013, with full data on clinical subtype available for 3049 patients (40.4% female; mean age 68.8 years). Common comorbidities were hypertension, coronary disease, and heart failure. Lone AF was present in only 3.9% (122 patients). Asymptomatic AF was common, particularly among those with permanent AF. Amiodarone was the most common antiarrhythmic agent used (∼20%), while beta-blockers and digoxin were the most used rate control drugs. Oral anticoagulants (OACs) were used in 80% overall, most often vitamin K antagonists (71.6%), with novel OACs being used in 8.4%. Other antithrombotics (mostly antiplatelet therapy, especially aspirin) were still used in one-third of the patients, and no antithrombotic treatment in only 4.8%. Oral anticoagulants were used in 56.4% of CHA2DS2-VASc = 0, with 26.3% having no antithrombotic therapy. A high HAS-BLED score was not used to exclude OAC use, but there was a trend towards more aspirin use in the presence of a high HAS-BLED score.CONCLUSION: The EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot Registry has provided systematic collection of contemporary data regarding the management and treatment of AF by cardiologists in ESC member countries. Oral anticoagulant use has increased, but novel OAC use was still low. Compliance with the treatment guidelines for patients with the lowest and higher stroke risk scores remains suboptimal.

Published
2014
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15. HIT Moderated Poster session: imaging in everyday practiceP143Relationship of FDG-PET and pressure-strain loops as novel measures of regional myocardial workload in LBBB-like dyssynchronyP144Cardiotoxicity of anti-vascular endothelial growth factor therapies: results of a pilot studyP145A new animal model of rapid pacing-induced dilated cardiomyopathy and LBBBP146Three-dimensional echocardiography assessment of the systolic variation of effective regurgitant orifice area in patients with functional tricuspid regurgitation: implications for quantificationP147Clinical prognostic value of myocardial mechanics using speckle-tracking echocardiography in patients post primary coronary intervention for acute ST- segment elevation myocardial infarctionP148Relationship between left atrial volumes and emptying fractions and parameters of infarct size and left ventricular filling pressures in survivors of st elevation myocardial infarctionP149Left atrial dysfunction assessed by two dimensional speckle tracking echocardiography in patients with impaired left ventricular ejection fraction and sleep-disordered breathingP150Left atrial morphological and functional remodeling early after ST elevation myocardial infarction insights from threedimensional echocardiographyP151Circumferential strain and strain rate at early stages of dobutamine speckle tracking imaging: are they enough to detect ischemia in patients with coronary artery disease?P152Pulmonary hypertension in hypertrophic cardiomyopathy: a rest and exercise echocardiography study

Author

Duchenne, J, primary, Popara-Voica, AM, primary, Aruta, P, primary, Teo, HK, primary, Onciul, S, primary, Miskowiec, D, primary, Rumbinaite, E, primary, Abellard, JA, primary, Turco, A, additional, Claus, P, additional, Vunckx, K, additional, Pagourelias, E, additional, Rega, F, additional, Gheysens, O, additional, Voigt, JU, additional, Croitoru, A, additional, Alexandru, D, additional, Geavlete, D O, additional, Popescu, B A, additional, Ginghina, C, additional, Jurcut, R, additional, Haemers, P, additional, Van Puyvelde, J, additional, Muraru, D, additional, Janei, C, additional, Haertel Miglioranza, M, additional, Cavalli, G, additional, Romeo, G, additional, Peluso, D, additional, Cucchini, U, additional, Iliceto, S, additional, Badano, L, additional, Kui, SL, additional, Chai, SC, additional, Leong, KT, additional, Tong, KL, additional, Miglioranza, MH, additional, Dorobantu, M, additional, Badano, LP, additional, Kupczynska, K, additional, Uznanska-Loch, B, additional, Kasprzak, JD, additional, Kurpesa, M, additional, Lipiec, P, additional, Vaskelyte, JJ, additional, Lapinskas, T, additional, Karuzas, A, additional, Zvirblyte, R, additional, Viezelis, M, additional, Jonauskiene, I, additional, Gustiene, O, additional, Slapikas, R, additional, Trochu, JN, additional, Gueffet, JP, additional, Cueff, C, additional, De Groote, P, additional, Bauters, C, additional, Millaire, A, additional, Polge, AS, additional, and Le Tourneau, T, additional

Published
2015
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16. Intravenous NPA for the treatment of infarcting myocardium early; InTIME-II, a double-blind comparison of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction

Author

Braunwald, E., Neuhaus, K. -L., Antman, E., Chew, P., Skene, A., Wilcox, R., Ambrosioni, E., Anderson, J., Apetrei, E., Bata, I., Carrageta, M., Col, J., Dalby, A., Davies, R., Deckers, J., Eichman, D., Grande, P., Greene, R., Gurfinkel, E., Heikkilä, J., Henry, T., Hillis, D., Hochman, J., Huber, K., Kostis, J., Klinke, P., López-Sendón, J., Mckendall, G., Móller, B., Moore, P., Morris, A., Mueller, H., Östör, E., Oto, A., Ruda, M., Sadowski, Z., Schweiger, M., Sequeira, R., Shah, P., Shannon, R., Smith, B., Sobel, B., Steingart, R., Tebbe, U., Toman, J., Traboulsi, M., Vahanian, A., Warnica, J. W., Willerson, J., Deitchman, D., Davidson, L., Folgia, T., Foxley, A., Goodman, J., Hauck, C., Henry, D., Mccabe, C., Pangerl, A., Thomson, A., Wagner, M., Kennedy, J. W., Cairns, J., Demets, D., Julian, D., Simoons, M., Charlesworth, A., Easton, J. D., Ferbert, A., Feske, S., Kuhn, P., Moseley, J., Rogg, J. M., Reichmann, H., Sloan, M., von Kummer, R., Zamani, A., Coulter, S., Giugliano, R., Skene, A. M., Ardill, R., Ince, Y., Peters, A., Ward, K., Wolf, L., Curtis, N., De Brés, J., Stead, S., Watson, S., Cutler, S., Friedman, J., Helfrick, R., Williams, S., Klimovsky, J., Kumagai, S., Adams, E., Anderson, C., Bauhuber, I., Bennett, L., Biro, E., Boyce, E., Bregman, B., Carvalho, P., Ciganovic, D., Csukas, M., Cuenca, P., De Cuyper, S., Diez, P., Dijkhuizen, M., Dille-Amo, C., Gonzalez-Santis, A., Gursoy, M., Hammarstrom, K., Harasta, E., Ingman, E., Kelemen, B., Keulen, I., Koren, A., Langthaler, G., Lemaire, F., Little, I., Montalban, C., Nijssen, K., Neumueller, I., Palander, M., Pekuri, T., Persson, U., Pilz, J., Oudotova, S., Pisklakov, V., Proinov, F., Ptaszynska, A., Read, J., Retei, S., Romeyer, F., Romanini, M., Saar, L., Salein, D., Samsonov, M., Simeon-Dubach, D., Simmonds, J., Skaza, M., Skvortsova, N., Smidlova, Z., Spitzerova, H., Strijdveen, I., Szajewski, T., Ugurnal, B., Valcarce, M., van Rompaey, I., Walker, A., Zak, E., Zimova, N., Barrero, C., Beck, E., Bruno, M. L., Caccavo, A., Cagide, A., Campo, A., Cermesoni, R., Chahin, M., Dutra, O., Estrada, J., Falu, E. A., Gagliardi, J., Garre, L. E., Liprandi, A. S., Luciardi, H., Mautner, B., Muntaner, J., Nau, G., Salzberg, S., Santopinto, J., Sinisi, A., Torres, H., Eber, B., Elliott, P., Hiemetsberger, H., Juhasz, M., Kühn, P., Leisch, F., Niktardjam, M., Reisinger, J., Schmalix, G., Schuster, R., Sihorsch, K., Silberhauer, K., Slany, J., Steinbach, K., Tragl, K. H., Valentin, A., Al Shwafi, K., Dasnoy, P., De Clippel, M., de Meester, A., De Raedt, H. J. L. P., Emonts, M., Evrard, P., Eycken, M., Geboers, M., Heyndrickx, G., Lauwers, K., Mitrie, K., Pirenne, B., Renard, M., Somers, Y., Timmermans, P., Van Kuyk, M., Van Mieghem, W., Vermeulen, J., Verrostte, J. M., Albuquerque, D., Ayoub, J. C. A., Carvalho, A., Cesar, L., Gebara, O., Golin, V., Knobel, E., Leaes, P., Neto, J. A. M., Nicolau, J. C., Piegas, L. S., Rabelo, A., Rassi, A., Sila, L., Simao, A. F., Ashton, T., Baillie, H., Bhargava, R., Bota, G., Cameron, W., Chan, N., Chan, Y. K., Daly, P. A., Darcel, I., Davies, E., Desjardin, L., Dhingra, S., Ducas, J., Ervin, F. L., Fortin, C., Fowlis, R., Fulop, J., Furey, M., Gagnon, S., Gebhardt, V., Giannaccro, P., Gosselin, G., Graham, J., Grondin, F., Heath, J. W., Henderson, M., Hilton, D. R., Hiscock, J., Hui, W., Kaza, L., Kesselman, T., Kouz, S., Kucerak, M., Lahoude, N., Lamothe, M., Lebouthillier, P., Lenis, J., Levesque, P., Lopez, J. F., Lubelsky, B., Macritchie, D., Mayer, J. -P., Mcdowell, J. D., Montigny, M., Orestien-Lyall, T., Parekh, P., Pistawka, K., Price, J. B., Pruneau, G., Quinn, B., Reid, B. R., Richmond, M., Rose, B., Schuld, R., Sharma, N. K., Shetty, P., Stanton, E., Strauss, H. D., Sussex, B., Theroux, P., Turabian, M., Turner, C., Vizel, S., Walker, M., Weeks, A., Winkler, L., Zacharias, G., Zimmerman, R., Bartolucci, J., Castro, P., Diaz, M. A., Illanes, G., Potthoff, S., Sanchez, E. C., Silva, L. M., Yovanovich, J., Zanetti, F. L., Alan, D., Balázová, K., Boček, P., Cerny, J., Fischerova, B., Holub, M., Hradec, J., Janota, T., Janský, P., Kasper, J., Klimsa, Z., Motovská, Z., Pleva, L., Pluhacek, L., Pšenčka, M., Semrád, B., Spinar, J., Staněk, V., Štípal, R., Suítil, P., Vítovec, J., Wichterie, D., Widimský, P., Zeman, K., Andersen, C. B., Kriegbaum, J., Nielsen, N., Nielsen, P. E., Schou, J. B., Teesalu, R., Voitk, J., Haapamäki, H. V. H., Halkosaari, M., Härkönen, M., Jägerholm, S., Kärjä-Koskenkari, P., Karthunen, P., Kesäniemi, Y. A., Koskivirta, H., Lehto, P., Lilja, M., Paakkinen, S., Palomäki, A. K., Pietilä, K., Tuominen, J., Viopio-Pulkki, L., Ylönen, H., Adi, I., Admant, P., Akadirik, A., Alagha, Z., Alhabaj, S., Amat, G., Andre, A. A., Apffel, F., Aswad, K., Baradat, G., Bareiss, P., Barthers, F. B., Baudet, M., Baudouy, M., Bearez, E. M., Berthou, J. D., Berzin, B., Bessede, G., Blanc, J. J., Bocara, A., Bonneau, A., Bourdad, C., Bouvier, J. M., Cassagnes, J., Cassat, A., Cazaux, P., Charbonnier, B., Clementy, J., Cohen, A., Coisne, D., Colin, P., Croizier, O., D’Hautefeuille, B., D’Ivernois, C., Daumas, P. L., Dauphin, C. L., Deforet, M. F., Degand, B., Dequeker, J. L., Dickele, M. C., Dugrand, P., Durand, S., Ebagosti, A., Elharrar, C., Equine, O., Fichter, E., Flork, L., Fouche, R., Fourchard, V., Fourme, T., Fournier, P. Y., Funck, F., Galley, D., Garbarz, E., Ghadban, W., Gladin, M., Grall, J. Y., Grand, A., Gryman, R., Guillard, N., Guillo, P., Haftel, Y., Hannebicque, G., Henry, R., Huret, J. F., Janin-Magnificat, L., Jarnier, J., Joly, A., Kamal, H., Khalife, A., Roynard, J. L., Lang, M., Lapeyssonnie, A., Ledain, L., Lejeune, P., Lemetayer, L., Lepori, R., Lombart, A., Lusson, J. R., Magnin, O., Marquand, A., Martelet, M. M., Martelli, A., Mathurin, C., Mentre, B., Messager, D., Morizot, M., Mouallem, M. J., Mouhoub, O., Mycimski, C., Nallet, O., Olive, T., Pacouret, G., Palcoux, M. C., Poulard, J. E., Pruvost, A., Quiret, J. C., Richard, C., Richard, P., Rickaud, P., Riehl-Aleil, V., Rifai, A., Rocher, R., Rotreff, P., Segrestin, B., Slama, M. S., Sultan, P., Tabone, X., Talbodec, A., Tissot, M. T., Toussaint, C., Veyrat, A., Zerrouk, Z., Adamczak, M., Altmann, E., Altybernd, B., Andreassen, G., Andresen, D., Appenrodt, H., Bachmann, S., Bäcker, U., Beckert, U., Behr, H. M., Beier, W., Beier, T., Berger, D., Bernsmeier, R., Beythien, R. D., Biechl, E., Biedermann, G., Bischoff, K. O., Blerich, J., Boch, H. B., Bonzel, T., Both, A. R., Breidenbach, K., Breuer, M., Breuer, H. W. M., Brunkhorst, F. B., Bruns, A., Bundschu, H. D., Burkhardt, W., Busse, H. J., Caesar, K., Cailloud, J., Chlosta, A., Chorlanopoulos, E., Consemüller, S., Decker, W., Dichgans, M., Dick, R., Diederich, K. W., Dienst, C., Dietz, A., Dißmann, R., Ditter, H., Doering, W., Drost, H., Dundalek, E. D., Eckardt, D., Edelmann, A., Eggeling, T., Eggert, G., Eichner, R., Endres, C., Engberding, R., Engel, H. J., Faehnrich, A., Fischer, J. L., Flor, A., Forycki, F. Z. F., Froböse, H. J., Fruehauf, T., Fuchs, M., Geiser, R., Geletneky, J., Gerdes, H., Gerecke, B., Gesing, S., Gieser, H., Girth, E., Glogner, P., Glover, M., Goetz, J., Goetz, H., Göttfert, G., Gottwik, M., Gregori, B., Grieshaber, M., Großmann, C., Gruber, G., Gunold, H., Häßler, W. H., Hackenjos, B., Hader, O., Hamer, H., Harmjanz, D., Hasst, G., Haun, H., Hauptmann, K. E., Hegge, F. J., Heinze, A., Heinze, R., Henrichs, K. J., Hergenröther, H., Herrmann, F., Herzig, C., Hey, D., Hill, S., Hinzmann, S., Hoffmann, S., Höfs, T., Höhler, H., Holle, G., Höltman, B. J., Horacek, T., Hossmann, V., Hübner, F. S., Hülskamp, C., Hunecke, R., Hust, M., Jaeckh, G., Jebens, C., Jennen, E., Jost, M., Justiz, R., Kallmann, L., Kalscheur, F., Kaschner, W., Kaspar, W., Kauder, E., Keitel, B., Keller, H., Kemkes, T., Kerler, N., Kester, M., Kettner, W., Kilp, M., Kirklies, A., Klaus, A., Klein, H. H., Klenböck, J. R., Kley, H. K., Klingenbeck, R., Koch, H., Kohler, B., Kohler, J., Kolloch, R., Konermann, M., Körber, H. G., Kother, T. K., Kötter, V., Kottwitz, B., Kozariszcsuk, G., Kracht, T., Kratzsch, G., Kreft, H. U., Kreuter, G., Krönert, H., Krönig, B., Krueger, E., Krülls-Münch, J., Kuckuk, H., Kuelschbach, M., Kuhrt-Lassay, O. W., Kummerhoff, P. W., Kunevt, R., Kurth, C. U., Lang, C., Lange, C., Langhoff, R., Laskus, A., Lazarus, P., Lehmann, H. U., Lenga, P., Lengfelder, W., Leupolz, W., Limbourg, P., Loos, U., Lucanus, W., Machill, K., Mäckel, P., Mackes, K. G., Maier, S., Makowski, B., Mandok, J., Manz, M., Mäurer, W., Meier, F., Meier, J., Menges, M., Merx, W., Meurers, G., Michels, U., Mickeler, C. H., Mons, D., Moos, E., Mueller, R., Müller, G., Nast, H. P., Naumann, G., Nebelsieck, H., Neubaur, J., Niederer, W., Nitsch, J., Noack, J., Nogai, K. F. W., Oberheiden, A., Obst, R., Ochs, H. R., Odemar, F., Odenthal, H. J. B., Offers, E., Öhl, S., Ohlmeier, H. A. R. M., Patzer, P., Pech, A., Peters, U., Petry, U., Pietschmann, G. J., Pistner, W., Plappert, B., Pohlmann, W. K., Pollock, B., Presser, H. J., Przytarski, K., Puerner, K. L., Raouf, N., Reike, N., Reil, G. H., Reinhard, U., Riebeling, V., Ritzmann, M., Rödder, J., Roth, E., Rüdelstein, R., Saborowski, F., Sauter, B., Sceffler, N., Schartl, A., Schifferdecker, E., Schlotterbeck, K. P., Schmidt, J., Schmidt-Dannert, D. R., Schmidt-Klewitz, H., Schmitz, H. J., Schnebelt, T., Schneider, H. L., Schneider, F. J., Schoeller, R., Scholz, D., Schoppe, W. D., Schreiner, G., Schroeder, J., Schuh, N., Schulte, K. L., Schulze, H., Schulze, H. D., Schuster, P., Schuster, H. P., Schweizer, P., Sechtem, U., Sedlmaier, H. P., Segel, S., Sehnert, W., Seidel, F., Siedentopf, K., Simon, H., Sodomann, C. P., Solbach, C., Sorges, E., Stabenow, S., Stadler, K. P., Stammwitz, E., Stein, U., Sternberg, H., Stiepak, C., Stockmann, M., Straus, W., Striegel, H., Struch, E., Strupp, G., Taubert, T. B. T., Thoeming, B., Thoß, A., Tinnappel, J., Tomsik, H., Topp, H., Troost, S., Öberreiter, A., Uebis, R., Ungler, T., Urbaszek, W., Vöhringer, H. F., von Arnim, T., von Leitner, E. R., von Löwis of Menar, A., von Mengden, H. J., von Smekal, P., Voss, W., Wacker, P., Warning, A., Warzecha, A., Wefers, U., Wehr, M., Weigel, H., Weissthanner, F., Weller, P., Werner, M., Wette, A., Wichert, H., Wielage, T., Wiese, U., Wilbrand, T. B., Wilhelms, E., Wilmsmann, G., Wolf, F. H., Wolf, T., Wonhas, F. C. M., Zastrow, B., Zeymer, U., Ziruler, S., Ziss, W., Zölch, K. A., Zwirner, K., Becker, D., Bosko, M., Csillag, I., Ermenyi, A., Fogas, J., Heltai, K., Jánosi, A., Katona, A., Kiraly, C., Kiss, B., Kutor, G., Mizik, R., Molnar, T., Mühl, M., Nagy, D., Palacti, I., Rudas, L., Sárosi, I., Simon, K., Sitkel, E., Sydó, T., Szaboki, F., Szikla, K., Szönyi, T., Timar, S., Vándor, L., Zamolyl, K., Walsh, M., Caspi, A., Swissa, M., Badano, L., Baldacci, G., Balli, E., Banda, D., Baretta, G., Boccalatte, A., Borgatti, M. L., Branzi, A., Burelli, C., Capelletti, D., Capucci, A., Caragiulo, D., Carbonieri, E., Cassin, M., Ceci, V., Cocchieri, M., Coletta, C., Conte, E., Contini, G. M., Corsini, G., D’Annunzio, E., De Blasi, M., De Luca, I., Delciterna, F., Di Pasquale, G., Diguardo, G., Fattore, L., Ferraiuulo, G., Finardi, A., Fioretti, P. M., Giunta, G., Guiducci, U., Guzzardi, G., Horando, G., Ignone, G., Lazzaroli, A., Levantesi, D., Liberati, R., Losi, E., Macor, F., Mangiameli, S., Martines, C., Meinardi, F., Morgera, T., Morozzi, L., Mostacci, M., Naccarella, F. F., Ottani, F., Palamara, A., Pani, A., Paperini, L., Pes, R., Pesola, A., Porzio, A., Raviele, A., Ricci, S., Rosi, A., Rossi, R., Rotiroti, D., Rusconi, L., Sabino, G., Saccone, V., Sanna, A., Scaramuzzino, G., Scorcu, G. P., Semprini, F., Severini, D., Staniscia, D., Tantalo, L., Tartagni, F., Terrosu, P., Tondelli, S., Trichero, R., Uslenghi, E., Vajola, S. F., Vetrano, A., Violi, E., Zardini, P., Zingarini, G. L., Zobbi, G., Zuin, G., Kalnins, U., Cârvekülg, A., Laanoca, J., Iacis, J., Lankiene, L., Laucevicius, A., Lukoseviciute, A., Palsauskaite, R., Petrauskiene, B., Soopóld, W., Uuetoa, H., Vilks, J., Vitonyte, R., Zakke, I., Dorantes, J., Hernández, H., Jerjes, C., Leva Garza, J. L., Martinez, C., Anneveldt, A., Baars, H. F., Baldew, S. C., Bendermacher, P. E. F., Boersma, L. V. A., Bos, R. J., Breedveld, R. W., Bruggink, P. W. F., Ciampricotti, R., Darmanata, J. I., de Porto, A. E., de Weerd, G. J., Deckers, J. W., Freericks, M. P., Hillebrand, F. A., Kerker, J. P., Koenen, J. C., Kofflard, M. G. M., Liem, K. L., Liem, A. H., Linssen, G. C. M., Lionarons, R. J., Peters, J. R. M., Posma, J. P., Saat, E. W. M., Savalle, L. H., Smits, W. C. G., Suttorp, M. J., Tans, A. C., Troquay, R. P. Th., van Beek, G. J., van Boven, A. J., Van der Heijden, R., Van Hessen, A., van Langeveld, R. A. M., van Lier, T. A. R., van Loo, L. W. H., van Wijngaarden, J., van Ziejl, L. G. P. M., Veerhoek, M. J., Vermer, F., Werner, H. A., Graven, T., Klykken, B., Meyerdieks, O., Omland, T. M., Otterstad, J. E., Pedersen, T., Rød, R., Banaszewski, M., Bednarkiewicz, Z., Bojarski, G., Ceremuzyñski, L., Czestochowska, E., Gajewski, M., Galewicz, M., Gorski, J., Grabczewska, Z. S., Gruchaka, M., Janicki, K., Janion, M., Jaworska, K., Jezewska, M., Kakol, J., Kizciuk, M., Kleinrok, A., Kolodziej, P., Komorowski, P., Konopka, A., Kopaczewski, J., Korecki, J., Kornacewicz-Jach, Z., Kowalewski, M., Kratochwil, D., Krolczyk, J., Krzminska-Pakula, M., Kurek, P., Kurowski, M., Kurpesa, M., Kurzawski, J., Kwiecien, R., Lenartowski, L., Lewandowski, M., Loboz-Grudzieñ, K., Luczak, G., Maliñski, A., Michalski, M., Musial, W., Nartowicz, E., Nowicka, A., Odyniec, A., Pasyk, S., Prastowski, W., Przybylski, A., Raczynska, A., Rodzik, J., Romanowski, M., Rynkiewicz, A., Rzyman, M., Sidorowicz, A., Sledziona, M., Sobiczewski, W., Sobkowicz, B., Sobolewska, J., Sokalski, L., Stepinska, J., Sterlinski, M., Stopinski, M., Świątecka, G., Szpernal, Z., Tarnowska, H., Trzos, E., Ujda, M., Wierzchowiecki, M., Wodynska, T., Wojciechowski, D., Wrabec, K., Wrzesinski, K., Zuk, P., Albuquergue, A., Costa, A., Cunha, D., Ferreira, D., Ferreira, R., Gaog Leiria, J. M., Pimenta, A., Rufino, E., Vasconcelos, J., Aldica, M., Balanescu, S., Bruckner, I. V., Capalneanu, R., Florescu, N., Georgescu, C. S., Cherasim, L., Ginshina, C., Merenta, A., Parvu, O., Radutiu, S., Savulescu, I., Vita, I., Averkov, O., Bokarev, I. N., Gratsiansky, N., Grigoriev, Y., Gruzdev, A., Kakhnovsky, I., Kheevehuk, T. V., Khrustalev, O., Kobalava, Y., Konoratieva, T. B., Koukline, Vladimir, Martiouchov, S., Pavlikova, E., Poskotinov, I., Rogalev, K., Sinopainikov, A., Syrkin, A., Tereschenko, S. T., Yavelov, I., Zavolghin, S., Čurilla, E., Kohn, R., Kovář, F., Murín, J., Poliačik, P., Drinovec, I., Horvat, M., Krivec, B., Markež, J., Pareznik, R., Pehnec, Z., Resman, J., Sifrer, F., Skale, R., Trinkaus, D., Voga, G., Baig, M. M. E., Blomerus, P., Botha, B. P., Burgess, L., Duncan, D., Duncan, D. I., Gillmer, D., Govender, N., Jardine, R. J., Kok, A., Manga, P., Naidu, R. K., Rajput, M. C., Ranjith, N., Roos, J. S., Snyders, F. A., Steingo, L., Stern, A., Tayob, F. Z., Vythilingum, S., Alonso-Orcajo, N., Arribas Jimenez, A., Ayestaran, J. I., Balsera, B. B. G., Barras, C., Castro, A., Cobo, N., Duque, A., Garcia, M. J., Goiriena, P., Gonzalez-Valdayo, M., Gulias Lopez, J. M., Jimenez Gomez, P., Lopez Garanda, V., Martín Santos, F., Nogueira, R., Pabon Osuna, P., Ponce De Leon, E., Quesada Dorador, A., Paya Serrano, R., Rodriguez, L., Rodriguez, M., Rubio, F., Ruiz-Salmeron, R., Solar, J., Toquero, J., Velasco, J., Vilar Herrero, V., Vizcaino, M., Wancisidor, X., Basilier, E., Birgersdotter, V., Björnsdotter, E., Bjurman, A., Hagström, D., Hallin, I., Hansen, O., Hemmingson, L. O., Lundkvist, L., Lycksell, M., Möller, B., Nolgard, P., Sjölund, G., Stjerna, A., Angehrn, W., de Benedetti, E., Diethelm, M., Gallino, A., Plebani, G., Vögelin, H. P., Wojtyna, W., Akgöz, H., Akgün, G., Akyürek, O., Batur, M. K., Bayata, S., Deger, N., Emel, O., Gürgün, C., Korkmaz, M. E., Kozan, O., Kumbasar, D., Muderrisoglu, H., Nisanci, Y., Ozin, B., Ozsaruhan, O., Payzin, S., Postaci, N., Sozcuer, H., Tamci, B., Topuzoglu, F., Türkoglu, C., Tutar, E., Ulucam, M., Ulusoy, T., Umman, B., Yalçinkaya, S., Yesil, M., Zoghi, M., Adams, P. C., Ahir, S., Ahsan, A. J., Akhtar, J., Albers, C. J., Al-Khafaji, M. N., Anderson, N., Bailey, R. J., Bain, R. J. I., Basu, A., Beal, A., Boyle, R. M., Brown, N., Campbell, S., Card, D., Cross, S. J., Davies, P., Davis, E. T. L., Dean, J. W., Deaner, A., Devine, M. A., Dhawan, J., Doig, J. C., Dubrey, S., Dunn, P. G., Dwight, J., Ecob, R., Fitzpatrick, H., Fletcher, S., Francis, C. M., Gershlick, A. H., Glennon, P. E., Goodfield, N. E., Grabau, W. J., Gray, M., Gray, K. E., Heath, J., Hendry, W. G., Highland, J., Hogg, K., Irving, J. B., James, M. A., Jennings, K., Joy, M., Kadr, H. H., Kahn, S., Keeling, P. J., Keir, P. M., Kemp, T. M., Kinaird, J., Kinsey, C., Knowles, K., Kooner, J. S., Lahiri, A., Lawson, C., Lewis, R., Macdermott, A. F. N., Mackay, A., Macleod, D. C., Mccance, A. J., Morrison, A., Mortimer, M., Mulvey, D., Murphy, J. J., Murray, S., Muthusamy, R., Myers, A., Nicolson, V. G., Northridge, D., Odemuyiwa, S., Oldroyd, K. G., Oliver, R. M., Pell, A. C. H., Pohl, J. E. F., Price, B., Quereshi, N., Rae, A. P., Reader, S., Reid, D. S., Reynolds, G. W., Robinson, A., Robson, R. H., Rodger, J. C., Rodrigues, E., Rose, E. L., Rowlands, D. B., Rowley, J. M., Rozkovec, A., Shreeve, J., Siklos, P., Smith, R. H., Sneddon, J. F., Somasundram, U., Squire, I., Stephens, J. D., Stephens-Lloyd, A., Strand, J. M., Stuart, J., Sutaria, N., Swan, J., Tait, G. W., Thomas, R. D., Thompson, M. A., Tildesley, G., Travill, C. M., Treadgold, J. A., Trelawney, J. M. S., Turner, D., Vallance, B. D., Wallbridge, D., Weissberg, P. L., White, E., Wicks, M., Wilcox, R. G., Wilkinson, P., Wiltshire, J. E., Wright, A., Andrea, B., Attassi, K., Bahr, R., Banas, J., Baran, K., Belknap, M., Bensman, M., Bertolet, B., Besley, D., Bethala, V., Betzu, R., Bhalla, R., Bhargava, M., Binder, A., Birkhead, R., Bodine, K., Brewer, D., Carey, S., Chengot, M., Coppola, J., Cragg, D., D’Arcy, B., Denny, D. M., Dilorenzo, P., Dixon, E., Doorey, A., Doty, D., Doty, W., Drossner, M., Eisenberg, P., Falco, T., Feldman, R., Freman, I., Frey, M., Garcia, J., Glassman, J., Goldman, S., Gomez, M., Gonzalez, M., Goodfield, P., Gottlieb, S., Grech, D., Hack, T., Haffey, T., Hanson, J., Havranek, E., Hermany, P., Hernandez, H., Herron, R., Hession, W., Hines, J., Hundley, R., Jacobs, W. C., Jerjes-Sanchez, C., Jerome, S., Josephson, R., Kalan, J., Kawalsky, D., Khan, A., Kmetzo, K., Kraemer, M., Lader, E., Landis, J., Lash, J., Leber, R., Leimbach, W., Leiva Garza, J. -L., Maddox, W., Magorien, R., Mahapatra, S., Mantecon, I., Mendelson, R., Miklin, J., Milas, J., Miller, R., Molk, B., Monrad, E. S., Morrison, J., Morse, H., Neustel, M., Nichols, D., Niederman, A., Nygaard, T., O’Connor, R., O’Riordan, W., Obermueller, S., Palmeri, S., Patel, R., Paul, T., Phiambolis, T., Piana, R., Polansky, B., Polinski, W., Ponce, G., Ribeiro, P., Roccario, E., Rogers, C. P., Rogers, W., Rosenblatt, A., Runyon, J. P., Scheel, F., Schmidt, P., Schneider, R., Schwartz, H., Shelhamer, L., Sheridan, F., Shine, W., Shook, T., Siskind, S., Slama, R., Spear, E., Stouffer, G., Strunk, B., Thadani, U., Timmis, G., Trautloff, R., Tse, A., Wohl, B., Zarren, H., Zucker, R., Kuster, F., and Pardie, J. P.

Subjects
Male, Risk, Infusions, medicine.medical_treatment, Myocardial Infarction, Bolus lytic therapy, Acute myocardial infarction, Tissue plasminogen activator, Thrombolytic drug, Double-Blind Method, Fibrinolytic Agents, medicine, Humans, Thrombolytic Therapy, Myocardial infarction, Infusions, Intravenous, Stroke, Aged, business.industry, ST elevation, Lanoteplase, Emergency department, Middle Aged, medicine.disease, Survival Analysis, Regimen, Relative risk, Anesthesia, Tissue Plasminogen Activator, Female, Intracranial Hemorrhages, Cardiology and Cardiovascular Medicine, business, Intravenous, medicine.drug
Abstract

AIMS To compare the efficacy and safety of lanoteplase, a single-bolus thrombolytic drug derived from alteplase tissue plasminogen activator, with the established accelerated alteplase regimen in patients presenting within 6 h of onset of ST elevation acute myocardial infarction. METHODS AND RESULTS 15,078 patients were recruited from 855 hospitals worldwide and randomized in a 2:1 ratio to receive either lanoteplase 120 KU. kg(-1)as a single intravenous bolus, or up to 100 mg accelerated alteplase given over 90 min. The primary end-point was all-cause mortality at 30 days and the hypothesis was that the two treatments would be equivalent. By 30 days, 6.61% of alteplase-treated patients and 6.75% lanoteplase-treated patients had died (relative risk 1.02). Total stroke occurred in 1.53% alteplase- and 1.87% lanoteplase-treated patients (ns); haemorrhagic stroke rates were 0.64% alteplase and 1.12% lanoteplase (P=0.004). The net clinical deficit of 30-day death or non-fatal disabling stroke was 7.0% and 7.2%, respectively. By 6 months, 8.8% of alteplase-treated patients and 8.7% of lanoteplase-treated patients had died. CONCLUSION Single-bolus weight-adjusted lanoteplase is an effective thrombolytic agent, equivalent to alteplase in terms of its impact on survival and with a comparable risk-benefit profile. The single-bolus regimen should shorten symptoms to treatment times and be especially convenient for emergency department or out-of-hospital administration.

Published
2000

17. Poster Session 2: Thursday 8 December 2011, 14:00-18:00 * Location: Poster Area

Author

Luo, X., primary, Fang, F., additional, Sun, J., additional, Xie, J., additional, Lee, A., additional, Zhang, Q., additional, Yu, C., additional, Breithardt, O., additional, Schiessl, S., additional, Schmid, M., additional, Seltmann, M., additional, Klinghammer, L., additional, Zeissler, C., additional, Kuechle, M., additional, Daniel, W., additional, Ege, M., additional, Guray, U., additional, Guray, Y., additional, Demirkan, B., additional, Kisacik, H., additional, Kim, S.-E., additional, Hong, J.-Y., additional, Lee, J.-H., additional, Park, D.-G., additional, Han, K.-R., additional, Oh, D.-J., additional, Tufekcioglu, O., additional, Cozma, D. C., additional, Mornos, C., additional, Ionac, A., additional, Petrescu, L., additional, Tutuianu, C., additional, Dragulescu, S. I., additional, Guimaraes, L., additional, Tavares, G., additional, Rodrigues, A., additional, Nagamatsu, C., additional, Fischer, C., additional, Vieira, M., additional, Oliveira, W., additional, Wilberg, T., additional, Cordovil, A., additional, Morhy, S., additional, Muraru, D., additional, Peluso, M., additional, Dal Bianco, L., additional, Beraldo, M., additional, Solda', E., additional, Tuveri, M., additional, Cucchini, U., additional, Al Mamary, A., additional, Badano, L., additional, Iliceto, S., additional, Pizzuti, A., additional, Mabritto, B., additional, Derosa, C., additional, Tomasello, A., additional, Rovere, M., additional, Parrini, I., additional, Conte, M., additional, Lareva, N., additional, Govorin, A., additional, Cooper, R., additional, Sharif, J., additional, Somauroo, J. D., additional, Hung, J. D., additional, Porcelli, V., additional, Skevington, R., additional, Shahzad, A., additional, Scott, S., additional, Lindqvist, P., additional, Soderberg, S., additional, Gonzalez, M., additional, Tossavainen, E., additional, Henein, M., additional, Nciri, N., additional, Saad, H., additional, Nawas, S., additional, Ali, A., additional, Youssufzay, A., additional, Safi, A., additional, Faruk, S., additional, Yurdakul, S., additional, Erdemir, V., additional, Tayyareci, Y., additional, Yildirimturk, O., additional, Memic, K., additional, Aytekin, V., additional, Gurel, M., additional, Aytekin, S., additional, Przewlocka-Kosmala, M., additional, Cielecka-Prynda, M., additional, Mysiak, A., additional, Kosmala, W., additional, Pescariu, S., additional, Cozma, D., additional, Mornos, A., additional, Dragulescu, S., additional, Maurea, N., additional, Tocchetti, C. G., additional, Coppola, C., additional, Quintavalle, C., additional, Rea, D., additional, Barbieri, A., additional, Piscopo, G., additional, Arra, C., additional, Condorelli, G., additional, Iaffaioli, R., additional, Dalen, H., additional, Thorstensen, A., additional, Moelmen, H., additional, Torp, H., additional, Stoylen, A., additional, Augustine, D., additional, Basagiannis, C., additional, Suttie, J., additional, Cox, P., additional, Aitzaz, R., additional, Lewandowski, A., additional, Lazdam, M., additional, Holloway, C., additional, Becher, H., additional, Leeson, P., additional, Radovanovic, S., additional, Djokovic, A., additional, Todic, B., additional, Zdravkovic, M., additional, Zaja-Simic, M., additional, Banicevic, S., additional, Lisulov-Popovic, D., additional, Krotin, M., additional, Grapsa, J., additional, O'regan, D., additional, Dawson, D., additional, Durighel, G., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Tulunay Kaya, C., additional, Kilickap, M., additional, Kurklu, H., additional, Ozbek, N., additional, Koca, C., additional, Kozluca, V., additional, Esenboga, K., additional, Erol, C., additional, Kusmierczyk-Droszcz, B., additional, Kowalik, E., additional, Niewiadomska, J., additional, Hoffman, P., additional, Satendra, M., additional, Sargento, L., additional, Lopes, S., additional, Longo, S., additional, Lousada, N., additional, Palma Reis, R., additional, Chillo, P., additional, Rieck, A., additional, Lwakatare, J., additional, Lutale, J., additional, Gerdts, E., additional, Bonapace, S., additional, Molon, G., additional, Targher, G., additional, Rossi, A., additional, Lanzoni, L., additional, Canali, G., additional, Campopiano, E., additional, Zenari, L., additional, Bertolini, L., additional, Barbieri, E., additional, Hristova, K., additional, Vladiomirova-Kitova, L., additional, Katova, T., additional, Nikolov, F., additional, Nikolov, P., additional, Georgieva, S., additional, Simova, I., additional, Kostova, V., additional, Kuznetsov, V. A., additional, Krinochkin, D. V., additional, Chandraratna, P. A., additional, Pak, Y. A., additional, Zakharova, E. H., additional, Plusnin, A. V., additional, Semukhin, M. V., additional, Gorbatenko, E. A., additional, Yaroslavskaya, E. I., additional, Bedetti, G., additional, Gargani, L., additional, Scalese, M., additional, Pizzi, C., additional, Sicari, R., additional, Picano, E., additional, Reali, M., additional, Canali, E., additional, Cimino, S., additional, Francone, M., additional, Mancone, M., additional, Scardala, R., additional, Boccalini, F., additional, Hiramoto, Y., additional, Frustaci, A., additional, Agati, L., additional, Savino, K., additional, Lilli, A., additional, Bordoni, E., additional, Riccini, C., additional, Ambrosio, G., additional, Silva, D., additional, Cortez-Dias, N., additional, Carrilho-Ferreira, P., additional, Jorge, C., additional, Silva-Marques, J., additional, Magalhaes, A., additional, Santos, L., additional, Ribeiro, S., additional, Pinto, F., additional, Nunes Diogo, A., additional, Kinova, E., additional, Zlatareva, N., additional, Goudev, A., additional, Bonanad, C., additional, Lopez-Lereu, M., additional, Monmeneu, J., additional, Bodi, V., additional, Sanchis, J., additional, Nunez, J., additional, Chaustre, F., additional, Llacer, A., additional, Ermacora, D., additional, Peluso, D., additional, Di Lazzari, M., additional, Meimoun, P., additional, Elmkies, F., additional, Benali, T., additional, Boulanger, J., additional, Zemir, H., additional, Clerc, J., additional, Luycx-Bore, A., additional, Velasco Del Castillo, M. S., additional, Cacicedo Fernandez De Bobadilla, A., additional, Onaindia Gandarias, J., additional, Telleria Arrieta, M., additional, Zugazabeitia Irazabal, G., additional, Quintana Raczka, O., additional, Rodriguez Sanchez, I., additional, Romero Pereiro, A., additional, Laraudogoitia Zaldumbide, E., additional, Lekuona Goya, I., additional, Bonello, B., additional, El Louali, E., additional, Fouilloux, V., additional, Kammache, I., additional, Ovaert, C., additional, Kreitmann, B., additional, Fraisse, A., additional, Migliore, R., additional, Adaniya, M., additional, Barranco, M., additional, Miramont, G., additional, Tamagusuku, H., additional, Alassar, A., additional, Sharma, R., additional, Marciniak, A., additional, Valencia, O., additional, Abdulkareem, N., additional, Jahangiri, M., additional, Jander, N., additional, Kienzle, R., additional, Gohlke-Baerwolf, C., additional, Gohlke, H., additional, Neumann, F.-J., additional, Minners, J., additional, Valbuena, S., additional, De Torres, F., additional, Lopez, T., additional, Gomez, J. J., additional, Guzman, G., additional, Dominguez, F., additional, Refoyo, E., additional, Moreno, M., additional, Lopez-Sendon, J. L., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Di Salvo, G., additional, Severino, S., additional, Cavallaro, M., additional, Calabro, R., additional, Enache, R., additional, Piazza, R., additional, Roman-Pognuz, A., additional, Popescu, B., additional, Calin, A., additional, Beladan, C., additional, Purcarea, F., additional, Nicolosi, G., additional, Ginghina, C., additional, Savu, O., additional, Rosca, M., additional, Jurcut, R., additional, Serban, M., additional, Dorobantu, L., additional, Donal, E., additional, Mascle, S., additional, Thebault, C., additional, Veillard, D., additional, Hamonic, H., additional, Leguerrier, A., additional, Corbineau, H., additional, Popa, B. A., additional, Diena, M., additional, Bogdan, A., additional, Benea, D., additional, Lanzillo, G., additional, Casati, V., additional, Novelli, E., additional, Popa, A., additional, Cerin, G., additional, Gual Capllonch, F., additional, Teis, A., additional, Lopez Ayerbe, J., additional, Ferrer, E., additional, Vallejo, N., additional, Gomez Denia, E., additional, Bayes Genis, A., additional, Spethmann, S., additional, Schattke, S., additional, Baldenhofer, G., additional, Stangl, V., additional, Laule, M., additional, Baumann, G., additional, Stangl, K., additional, Knebel, F., additional, Labata, C., additional, Garcia Alonso, C., additional, Gual, F., additional, Nunez Aragon, R., additional, Sousa, C., additional, Vasile, A. I., additional, Dorobantu, M., additional, Iorgulescu, C., additional, Bogdan, S., additional, Constantinescu, D., additional, Caldararu, C., additional, Tautu, O., additional, Vatasescu, R., additional, Badran, H., additional, Elnoamany, M. 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M., additional, Marek, D., additional, Vindis, D., additional, Kocianova, E., additional, Taborsky, M., additional, Yoon, H., additional, Kim, K., additional, Ahn, Y., additional, Chung, M., additional, Cho, J., additional, Kang, J., additional, Rha, W., additional, Ozcan, O., additional, Sezgin Ozcan, D., additional, Candemir, B., additional, Aras, M., additional, Dincer, I., additional, Atak, R., additional, Gianturco, L., additional, Turiel, M., additional, Atzeni, F., additional, Tomasoni, L., additional, Bruschi, E., additional, Epis, O., additional, Sarzi-Puttini, P., additional, Aggeli, C., additional, Poulidakis, E., additional, Felekos, I., additional, Sideris, S., additional, Dilaveris, P., additional, Gatzoulis, K., additional, Stefanadis, C., additional, Roszczyk, N., additional, Sobczak, M., additional, Peruga, J., additional, Krecki, R., additional, Kasprzak, J., additional, Ishii, K., additional, Suyama, T., additional, Kataoka, K., additional, Furukawa, A., additional, Nagai, T., additional, Maenaka, M., additional, Seino, Y., additional, Musca, F., additional, De Chiara, B., additional, Moreo, A., additional, Cataldo, S., additional, Parolini, M., additional, Parodi, O., additional, Bombardini, T., additional, Faita, F., additional, Park, S.-J., additional, Kil, J.-H., additional, Kim, S.-J., additional, Jang, S.-Y., additional, Chang, S.-A., additional, Choi, J.-O., additional, Lee, S.-C., additional, Park, S., additional, Park, P., additional, Oh, J., additional, Cikes, M., additional, Velagic, V., additional, Biocina, B., additional, Gasparovic, H., additional, Djuric, Z., additional, Bijnens, B., additional, Milicic, D., additional, Huqi, A., additional, Klas, B., additional, He, A., additional, Paterson, I., additional, Irween, M., additional, Ezekovitz, J., additional, Choy, J., additional, Chen, Y., additional, Cheng, L., additional, Yao, R., additional, Yao, H., additional, Chen, H., additional, Pan, C., additional, Shu, X., additional, Sobkowicz, B., additional, Kaminska, M., additional, Musial, W., additional, Buechel, R., additional, Sommer, G., additional, Leibundgut, G., additional, Rohner, A., additional, Bremerich, J., additional, Kaufmann, B., additional, Kessel-Schaefer, A., additional, Handke, M., additional, Kiotsekoglou, A., additional, Saha, S., additional, Toole, R., additional, Sharma, S., additional, Gopal, A., additional, Adhya, S., additional, Tsang, W., additional, Kenny, C., additional, Kapetanakis, S., additional, Lang, R., additional, Monaghan, M., additional, Smith, B., additional, Coulter, T., additional, Rendon, A., additional, Cheung, W.-S., additional, Gorissen, W., additional, Ejlersen, J. A., additional, May, O., additional, Van Slochteren, F. J., additional, Van Der Spoel, T., additional, Hanssen, H., additional, Doevendans, P., additional, Chamuleau, S., additional, De Korte, C., additional, Tarr, A., additional, Stoebe, S., additional, Trache, T., additional, Kluge, J.-G., additional, Varga, A., additional, Hagendorff, A., additional, Nagy, A., additional, Kovacs, A., additional, Apor, A., additional, Sax, B., additional, Becker, D., additional, Merkely, B., additional, Lindquist, R., additional, Miller, A., additional, Reece, C., additional, Eidem, B. W., additional, Choi, W.-G., additional, Kim, S., additional, Oh, S., additional, Kim, Y., additional, Iacobelli, R., additional, Chinali, M., additional, D' Asaro, M., additional, Toscano, A., additional, Del Pasqua, A., additional, Esposito, C., additional, Seghetti, G., additional, Parisi, F., additional, Pongiglione, G., additional, Rinelli, G., additional, Omaygenc, O., additional, Bakal, R., additional, Dogan, C., additional, Teber, K., additional, Akpinar, S., additional, Sahin, G., additional, Ozdemir, N., additional, Penhall, A., additional, Joseph, M., additional, Chong, F., additional, De Pasquale, C., additional, Selvanayagam, J., additional, Leong, D., additional, Nyktari, E. G., additional, Patrianakos, A. P., additional, Goudis, C., additional, Solidakis, G., additional, Parthenakis, F., additional, Vardas, P., additional, Nestaas, E., additional, Fugelseth, D., additional, Vitarelli, A., additional, Capotosto, L., additional, Bernardi, M., additional, Conde, Y., additional, Caranci, F., additional, Placanica, G., additional, Dettori, O., additional, Vitarelli, M., additional, De Chiara, S., additional, De Cicco, V., additional, Ferro', M., additional, Calabro', R., additional, Apostolakis, S., additional, Chalikias, G., additional, Tziakas, D., additional, Stakos, D., additional, Thomaidi, A., additional, Konstantinides, S., additional, Iorio, G., additional, Rucos, R., additional, Continanza, G., additional, D Ascanio, M., additional, Alessandroni, L., additional, Saponara, M., additional, Berry, M., additional, Nahum, J., additional, Zaghden, O., additional, Monin, J., additional, Couetil, J., additional, Lairez, O., additional, Macron, L., additional, Dubois Rande, J., additional, Gueret, P., additional, Lim, P., additional, Cameli, M., additional, Giacomin, E., additional, Lisi, M., additional, Benincasa, S., additional, Righini, F., additional, Menci, D., additional, Focardi, M., additional, Mondillo, S., additional, Philip, E., additional, Gorincour, G., additional, Bellsham-Revell, H., additional, Bell, A. J., additional, Miller, O. I., additional, Beerbaum, P., additional, Razavi, R., additional, Greil, G., additional, Simpson, J. M., additional, Ann, S., additional, Kim, T., additional, Lee, J., additional, Chin, J., additional, Cabeza Lainez, P., additional, Escolar Camas, V., additional, Gheorghe, L., additional, Fernandez Garcia, P., additional, Vazquez Garcia, R., additional, Caiulo, V., additional, Caiulo, S., additional, Fisicaro, A., additional, Moramarco, F., additional, Latini, G., additional, Seale, A., additional, Carvalho, J., additional, Gardiner, H., additional, Roughton, M., additional, Simpson, J., additional, Tometzki, A., additional, Uzun, O., additional, Webber, S., additional, Daubeney, P., additional, Dawood, A., additional, Dwivedi, G., additional, Mahadevan, G., additional, Jiminez, D., additional, Steeds, R., additional, Frenneaux, M., additional, Attenhofer Jost, C. H., additional, Knechtle, B., additional, Bernheim, A., additional, Pfyffer, M., additional, Linka, A., additional, Faeh-Gunz, A., additional, Seifert, B., additional, De Pasquale, G., additional, Zuber, M., additional, Tomaszewski, A., additional, Kutarski, A., additional, and Tomaszewski, M., additional

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2011
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18. Poster session IV * Friday 10 December 2010, 14:00-18:00

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Mora, B., primary, Base, E., additional, Schmid, W., additional, Andreas, M., additional, Weber, U., additional, Junreitmaier, M., additional, Foerster, F., additional, Hiesmayr, M., additional, Tschernich, H. D., additional, Guldbrand, D., additional, Goetzsche, O., additional, Eika, B., additional, Fumagalli, S., additional, Francini, S., additional, Gabbai, D., additional, Pedri, S., additional, Casalone Rinaldi, M., additional, Makhanian, Y., additional, Sollami, R., additional, Tarantini, F., additional, Marchionni, N., additional, Azcarate, P. M., additional, Castano, S., additional, Rodriguez-Manero, M., additional, Arraiza, M., additional, Levy, B., additional, Barba, J., additional, Rabago, G., additional, Bastarrika, G., additional, Rus, H., additional, Radoi, M., additional, Ciurea, C., additional, Boda, D., additional, Erdei, T., additional, Denes, M., additional, Mihalcz, A., additional, Kardos, A., additional, Foldesi, C. S., additional, Temesvari, A., additional, Lengyel, M., additional, Cameli, M., additional, Lisi, M., additional, Righini, F., additional, Ballo, P., additional, Henein, M., additional, Mondillo, S., additional, Nistri, S., additional, Galderisi, M., additional, Ballo, P. C., additional, Pagliani, L., additional, Olivotto, I., additional, Santoro, A., additional, Papesso, B., additional, Innelli, P., additional, Cecchi, F., additional, Hristova, K., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Nesheva, N., additional, Ivanovic, B., additional, Tadic, M. T., additional, Simic, D. S., additional, Rao, C. M., additional, Aguglia, D., additional, Casciola, G., additional, Imbesi, C., additional, Marvelli, A., additional, Sgro, M., additional, Benedetto, D., additional, Tripepi, G., additional, Zoccali, C., additional, Benedetto, F. A., additional, Mantziari, L., additional, Kamperidis, V., additional, Damvopoulou, E., additional, Ventoulis, I., additional, Giannakoulas, G., additional, Paraskevaidis, S., additional, Vassilikos, V., additional, Karvounis, H., additional, Styliadis, I. H., additional, Sonder, T. K., additional, Loegstrup, B. B., additional, Lambrechtsen, J., additional, Van Bortel, L. M., additional, Segers, P., additional, Egstrup, K., additional, Tho, A., additional, Moceri, P., additional, Bertora, D., additional, Gibelin, P., additional, Cho, E. J., additional, Choi, K. Y., additional, Kim, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Park, C. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Donal, E., additional, Coquerel, N., additional, Bodi, S., additional, Thebault, C., additional, Kervio, G., additional, Carre, F., additional, Daly, M. J., additional, Fairley, S. L., additional, Doherty, R., additional, Ashfield, K., additional, Kirkpatrick, R., additional, Smith, B., additional, Buchanan, J., additional, Hill, L., additional, Dixon, L. J., additional, Rosca, M., additional, O' Connor, K., additional, Magne, J., additional, Romano, G., additional, Calin, A., additional, Popescu, B. A., additional, Beladan, C. 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I., additional, Tintoiu, I., additional, Greere, V., additional, Cristian, G., additional, Chiriac, L., additional, Pinte, F., additional, Droc, I., additional, Neagoe, G., additional, Stanciu, S., additional, Voicu, V. A., additional, Kuch-Wocial, A., additional, Pruszczyk, P., additional, Szmigielski, C. A., additional, Szulc, M., additional, Styczynski, G., additional, Sinski, M., additional, Kaczynska, A., additional, Ryabikov, A., additional, Malyutina, S., additional, Halcox, J., additional, Bobak, M., additional, Nikitin, Y. U., additional, Marmot, M., additional, Barbosa, D., additional, Kiss, G., additional, Orderud, F., additional, Amundsen, B., additional, Jasaityte, R., additional, Loeckx, D., additional, Claus, P., additional, Torp, H., additional, D'hooge, J., additional, Kuhl, J. T., additional, Lonborg, J., additional, Fuchs, A., additional, Andersen, M., additional, Vejlstrup, N., additional, Engstrom, T., additional, Moller, J. E., additional, Kofoed, K. F., additional, Smith, L. A., additional, Bhan, A., additional, Paul, M., additional, Monaghan, M. J., additional, Zaborska, B., additional, Stec, S., additional, Sikora-Frac, M., additional, Krynski, T., additional, Kulakowski, P., additional, Pushparajah, K., additional, Dashwood, D., additional, Barlow, A., additional, Nugent, K., additional, Miller, O., additional, Simpson, J., additional, Valeur, N., additional, Ersboll, M. K., additional, Kjaergaard, J., additional, Greibe, R., additional, Risum, N., additional, Hassager, C., additional, Kober, L., additional, Popovic, D., additional, Nedeljkovic, I., additional, Petrovic, M., additional, Vujisic-Tesic, B., additional, Arandjelovic, A., additional, Stojiljkovic, S., additional, Jakovljevic, B., additional, Damjanovic, S., additional, Ostojic, M., additional, Agrios, I. A., additional, Bramos, D. B., additional, Skaltsiotis, H. S., additional, Takos, D. T., additional, Kaladaridis, A., additional, Vasiladiotis, N. V., additional, Kottis, G. K., additional, Antoniou, A. A., additional, Pamboucas, C. P., additional, Toumanidis, S. T. T., additional, Locorotondo, G., additional, Porto, I., additional, Paraggio, L., additional, Fedele, E., additional, Barchetta, S., additional, De Caterina, A. R., additional, Rebuzzi, A. G., additional, Crea, F., additional, Galiuto, L., additional, Lipiec, P., additional, Szymczyk, E., additional, Michalski, B., additional, Wozniakowski, B., additional, Stefanczyk, L., additional, Rotkiewicz, A., additional, Shim, A., additional, Vainer, J., additional, Habets, J., additional, Lousberg, A., additional, Pont De, C., additional, Waltenberger, J., additional, Farouk, H., additional, Heshmat, H., additional, Adel, A., additional, El Chilali, K., additional, Baghdady, Y., additional, Sorour, K., additional, Gustafsson, U., additional, Larsson, M., additional, Bjallmark, A., additional, Lindqvist, P., additional, A'roch, R., additional, Haney, M., additional, Waldenstrom, A., additional, Mladenovic, Z., additional, Tavciovski, D., additional, Mijailovic, Z., additional, Djordjevic - Dikic, A., additional, Obradovic, S., additional, Matunovic, R., additional, Jovic, Z., additional, Djuric, P., additional, Aase, S., additional, Dalen, H., additional, Sarkola, T., additional, Redington, A. N., additional, Keeley, F., additional, Bradley, T., additional, Jaeggi, E., additional, and Sahlen, H., additional

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2010
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19. Poster session II * Thursday 9 December 2010, 14:00-18:00

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Pabari, P. A., primary, Kyriacou, A., additional, Moraldo, M., additional, Unsworth, B., additional, Baruah, R., additional, Sutaria, N., additional, Hughes, A., additional, Mayet, J., additional, Francis, D. P., additional, Uejima, T., additional, Loboz, K., additional, Antonini-Canterin, F., additional, Polombo, C., additional, Carerj, S., additional, Vinereanu, D., additional, Evangelista, A., additional, Leftheriotis, G., additional, Fraser, A. G., additional, Kiotsekoglou, A., additional, Govindan, M., additional, Govind, S. C., additional, Saha, S. K., additional, Camm, A. J., additional, Azcarate, P. M., additional, Castano, S., additional, Rodriguez-Manero, M., additional, Arraiza, M., additional, Levy, B., additional, Barba, J., additional, Rabago, G., additional, Bastarrika, G., additional, Nemes, A., additional, Takacs, R., additional, Varkonyi, T., additional, Gavaller, H., additional, Baczko, I., additional, Forster, T., additional, Wittmann, T., additional, Papp, J. G., additional, Lengyel, C., additional, Varro, A., additional, Tumasyan, L. R., additional, Adamyan, K. G., additional, Savu, O., additional, Mieghem, T., additional, Dekoninck, P., additional, Gucciardo, L., additional, Jurcut, R., additional, Giusca, S., additional, Popescu, B. A., additional, Ginghina, C., additional, Deprest, J., additional, Voigt, J. U., additional, Versiero, M., additional, Galderisi, M., additional, Esposito, R., additional, Rapacciuolo, A., additional, Esposito, G., additional, Raia, R., additional, Morgillo, T., additional, Piscione, F., additional, De Simone, G., additional, Oraby, M. A., additional, Maklady, F. A., additional, Mohamed, E. M., additional, Eraki, A. Z., additional, Zaliaduonyte-Peksiene, D., additional, Tamuleviciute, E., additional, Janenaite, J., additional, Marcinkeviciene, J., additional, Mizariene, V., additional, Bucyte, S., additional, Vaskelyte, J., additional, Trifunovic, D., additional, Nedeljkovic, I., additional, Popovic, D., additional, Ostojic, M., additional, Vujisic-Tesic, B., additional, Petrovic, M., additional, Stankovic, S., additional, Sobic-Saranovic, D., additional, Banovic, M., additional, Dikic-Djordjevic, A., additional, Savino, K., additional, Lilli, A., additional, Grikstaite, E., additional, Giglio, V., additional, Bordoni, E., additional, Maragoni, G., additional, Cavallini, C., additional, Ambrosio, G., additional, Jakovljevic, B., additional, Beleslin, B., additional, Nedeljkovic, M., additional, Petrovic, O., additional, Moral, S., additional, Rodriguez-Palomares, J., additional, Descalzo, M., additional, Marti, G., additional, Pineda, V., additional, Mahia, P., additional, Gutierrez, L., additional, Gonzalez-Alujas, T., additional, Garcia-Dorado, D., additional, Schnell, F., additional, Donal, E., additional, Thebault, C., additional, Bernard, A., additional, Corbineau, H., additional, Le Breton, H., additional, Kochanowski, J., additional, Scislo, P., additional, Piatkowski, R., additional, Roik, M., additional, Marchel, M., additional, Kosior, D., additional, Opolski, G., additional, Lesniak-Sobelga, A. 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C., additional, Mady, C. M., additional, Picard, M. H. P., additional, Salemi, V. M. C., additional, Funk, L., additional, Prull, M. W., additional, Shih, J.-Y., additional, Huang, Y.-Y., additional, O'connor, K., additional, Moonen, M., additional, Pierard, L. A., additional, Cozma, D. C., additional, Mornos, C., additional, Ionac, A., additional, Petrescu, L., additional, Dragulescu, D., additional, Dan, R., additional, Popescu, I., additional, Dragulescu, S. I., additional, Von Lueder, T. G., additional, Hodt, A., additional, Gjerdalen, G. F., additional, Andersen, T. E., additional, Solberg, E. E., additional, Steine, K., additional, Van Mieghem, T., additional, Rostek, M., additional, Pikto-Pietkiewicz, W., additional, Dluzniewski, M., additional, Antoniewicz, A., additional, Poletajew, S., additional, Borowka, A., additional, Pasierski, T., additional, Malyutina, S. K., additional, Ryabikov, M., additional, Ragino, J., additional, Ryabikov, A., additional, Sitia, S., additional, Tomasoni, L., additional, Atzeni, F., additional, Gianturco, L., additional, Sarzi-Puttini, P., additional, De Gennaro Colonna, V., additional, Turiel, M., additional, Gutierrez, F. R., additional, Lefhtheriotis, G., additional, Hurst, R. T., additional, Nelson, M. R., additional, Mookadam, F., additional, Thota, V., additional, Emani, U., additional, Al Harthi, M., additional, Stepanek, J., additional, Cha, S., additional, Lester, S. J., additional, Ho, E. M. M., additional, Hemeryck, L., additional, Hall, M., additional, Scott, K., additional, Bennett, K., additional, Mahmud, A., additional, Daly, C., additional, King, G., additional, Murphy, R. T., additional, Brown, A. S., additional, Teske, A. 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Q., additional, Gu, Y., additional, and Tan, R. S., additional

Published
2010
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24. Impact of gender on left ventricle function in postmenopausal women and age-matched men: analysis of echocardiographic parameters in healthy participants and patients with coronary artery disease.

Author

Wierzbowska-Drabik K, Krzeminska-Pakula M, Kurpesa M, Trzos E, Rechcinski T, Wejner-Mik P, Plewka M, Kasprzak JD, Wierzbowska-Drabik, Karina, Krzemińska-Pakuła, Maria, Kurpesa, Małgorzata, Trzos, Ewa, Rechciński, Tomasz, Wejner-Mik, Paulina, Plewka, Michał, and Kasprzak, Jarosław D

Published
2010
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25. Age-dependency of classic and new parameters of diastolic function.

Author

Wierzbowska-Drabik K, Krzeminska-Pakula M, Chrzanowski U, Plewka M, Waszyrowski T, Drod J, Kurpesa M, Trzos E, and Kasprzak JD

Abstract

Age-dependency has been demonstrated for classic diastolic parameters but is less documented for novel markers. We compared wide spectrum of diastolic measurements in healthy subjects younger and older than 50 and 70 years. Method: In 80 subjects (17 to 91 year, 38 male, mean age 53 +/- 16) we assessed in transthoracic echocardiography mitral inflow, pulmonary vein flow, propagation velocity, and tissue Doppler parameters. The data were compared between the groups: A < 50, B 50-70, and C > 70 years and their correlation with age was analyzed. Result: In the older groups a longer duration of isovolumic relaxation, higher velocity of mitral inflow atrial phase, and lower early to atrial mitral inflow velocity ratio (E/A) were observed. In pulmonary veins ratio of peak systolic to diastolic velocity (S/D) was higher and atrial reversal flow faster. Among the new parameters in older groups a lower propagation velocity of early wave (Ep) (30 +/- 8 in C, 44 +/- 10 in B vs 49+/-9 cm/s in A;P< 0.05) and peak early diastolic velocity of mitral annulus (E' 9.5 +/- 1.8 in C and 11.2 +/- 2.9 in B vs 15.8 +/- 4.1 cm/s in A,P< 0.05) were recorded. Conclusions: Besides the evolution of mitral inflow toward the delayed relaxation profile in elderly, a decrease of propagation and tissue Doppler velocities were documented. The strongest positive correlation with age was observed for atrial velocity of mitral inflow (A, r = 0.63) and inverse correlation for E/A ratio (r =-0.6) and early diastolic velocity of mitral annulus (r =-0.69). [ABSTRACT FROM AUTHOR]

Published
2008
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26. Enlarged left atrium is a simple and strong predictor of poor prognosis in patients after myocardial infarction.

Author

Wierzbowska-Drabik K, Krzeminska-Pakula M, Drozdz J, Plewka M, Trzos E, Kurpesa M, Rechcinski T, Rózga A, Plonska-Gosciniak E, and Kasprzak JD

Abstract

Background and Aim: Patients after myocardial infarction (MI) differ according to the extend of myocardial damage and prognosis. Diastolic function impairment may have great impact on development of heart failure and outcomes. We evaluated the prognostic value of various echocardiographic measurements in 18-month and 3-year observation after MI. Methods: 60 patients after MI (44 male, mean age 60 +/- 11) were examined by transthoracic echocardiography with the assessment of wide spectrum of parameters. Mortality and combined end points (cardiac deaths and heart failure exacerbation) were assessed after 18-month and 3-year observation and groups with and without end points were compared. Optimal cutoff values were estimated by receiver operating characteristic (ROC) analysis and resulting Kaplan-Meier curves were compared. Results and Conclusions: After 18 months, 11 deaths occurred and 20 subjects experienced hospitalization caused by heart failure exacerbation. Although the group with cardiac events showed a greater enlargement of the left ventricle and lower ejection fraction, the highest relative risk of poor outcome (RR = 5.0) was related to the left atrial enlargement above 44 mm. Although restrictive or pseudonormal inflows were connected with 2.1 relative risk of combined end point, all patients with E deceleration time

Published
2008
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27. The relationship between heart rate variability and heart rate turbulence dynamics after primary coronary angioplasty.

Author

Kurpesa M, Trzos E, Rechcinski T, Krzeminska-Pakula M, Kurpesa, Małgorzata, Trzos, Ewa, Rechciński, Tomasz, and Krzemińska-Pakuła, Maria

Abstract

Background: The application of heart rate turbulence (HRT) analysis for risk assessment after pharmacologically treated myocardial infarction (MI) was described in 1999. The aim of the present study was to evaluate the dynamics of HRT changes in long-term observation after MI treated with primary coronary angioplasty (PTCA). Moreover, the usefulness was assessed of early postinfarction heart rate variability (HRV) analysis for predicting HRT dynamics.Methods: The study group consisted of 96 patients with MI treated with primary PTCA. Holter monitoring with HRV and HRT analysis was performed 3 days after the procedure and 1 year later.Results: Twelve months after primary PTCA, an improvement (Type I HRT dynamics) was noted in 51 patients, and the worsening of both the HRT parameters (Type II HRT dynamics) in 34 patients. Fourteen patients showed the worsening of only one HRT parameter (Type III HRT dynamics). The following HRV parameters recorded in early postinfarction Holter monitoring had a significant influence on the risk of Type II HRT dynamics: SDNN, RMSSD, Triangle Index and Delta LF/HF (mean day-time LF/HF - mean night-time LF/HF). Only the latter was found in the multivariate analysis as significantly connected with worsened HRT. During the follow-up, SDNN and Triangular Index improved in all the patients.Conclusions: HRT after myocardial infarction treated with primary PTCA presents a significant dynamics, which is different than dynamics of HRV. An abnormal circadian pattern of autonomic activity is a finding that helps identify patients who need to have HRT analysis repeated during a long-term follow-up, due to the tendency for HRT to change with time toward the prognostically unfavorable values. [ABSTRACT FROM AUTHOR]

Published
2007

28. White blood cell count and the occurrence of silent ischemia after myocardial infarction.

Author

Kurpesa M, Trzos E, Krzeminska-Pakula M, Kurpesa, Małgorzata, Trzos, Ewa, and Krzemińska-Pakuła, Maria

Abstract

Background: Inflammation plays a role in the pathogenesis of atherosclerosis. Attempts are made to use markers of inflammation as prognostic factors in coronary artery disease and acute coronary syndromes. The correlation between inflammation and silent postinfarction ischemia is unknown.Methods: The study population consists of 104 asymptomatic patients who had uncomplicated Q-wave myocardial infarction within 6 months prior to the enrollment. After the white blood cell (WBC) count was assessed, the population was divided into two groups: group I comprising 48 patients with WBC < or = 7.0 x 103/microl and group II comprising 56 patients with WBC > 7.0 x 103/microl. Twenty-four-hour Holter monitoring was performed to detect the presence of silent ischemia.Results: Eighty-eight silent ischemic episodes were recorded. Ischemia on Holter monitoring was detected in 47 patients (84%) from group II and in five patients (9%) in group I (P < 0.01). We have found a significant positive correlation between WBC count and the number of ischemic episodes (r = 0.25), their maximal amplitude (r = 0.39), duration (r = 0.34), and total ischemic burden (r = 0.36). In multivariate analysis leucocytosis proved to be the only parameter independently correlated with the presence of silent ischemia.Conclusion: Postinfarction asymptomatic patients with increased WBC count are more likely to have residual ischemia. [ABSTRACT FROM AUTHOR]

Published
2003

49. HIT Moderated Poster session: imaging in everyday practice

Author

Duchenne, J, Turco, A, Claus, P, Vunckx, K, Pagourelias, E, Rega, F, Gheysens, O, Voigt, JU, Popara-Voica, AM, Croitoru, A, Alexandru, D, Geavlete, D O, Popescu, B A, Ginghina, C, Jurcut, R, Duchenne, J, Claus, P, Turco, A, Vunckx, K, Pagourelias, E, Haemers, P, Van Puyvelde, J, Gheysens, O, Rega, F, Voigt, JU, Aruta, P, Muraru, D, Janei, C, Haertel Miglioranza, M, Cavalli, G, Romeo, G, Peluso, D, Cucchini, U, Iliceto, S, Badano, L, Teo, HK, Kui, SL, Chai, SC, Leong, KT, Tong, KL, Onciul, S, Muraru, D, Miglioranza, MH, Cucchini, U, Dorobantu, M, Iliceto, S, Badano, LP, Miskowiec, D, Kupczynska, K, Uznanska-Loch, B, Kasprzak, JD, Kurpesa, M, Lipiec, P, Onciul, S, Muraru, D, Miglioranza, MH, Cucchini, U, Dorobantu, M, Iliceto, S, Badano, LP, Rumbinaite, E, Vaskelyte, JJ, Lapinskas, T, Karuzas, A, Zvirblyte, R, Viezelis, M, Jonauskiene, I, Gustiene, O, Slapikas, R, Abellard, JA, Trochu, JN, Gueffet, JP, Cueff, C, De Groote, P, Bauters, C, Millaire, A, Polge, AS, and Le Tourneau, T

Abstract

Purpose: To investigate the relationship between two measures of regional myocardial workload (RMW): regional myocardial glucose metabolism, assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and regional LV pressure-strain loop area. Both were evaluated in a chronic rapid pacing animal model of dilated cardiomyopathy (DCM) and LBBB-like mechanical dyssynchrony. Methods: Nine sheep were subjected to rapid RV pacing (180 bpm), developing LV dilatation and asymetric remodelling, with LBBB-like ventricular activation. After 8 weeks all animals underwent two FDG-PET scans: one under normal LV conduction (AAI pacing), another under LBBB-like activation (DDD pacing). Potential inhomogeneities in RMW represented by FDG-uptake, were then evaluated. Before the last PET scan, all animals were subjected to invasive pressure-volume and simultaneous echocardiographic circumferential strain (CS) analysis of the mid-ventricular segments. Segmental pressure-CS-loop area was then recorded as alternative measure of RMW and compared to PET results. Results: DDD and AAI pacing led to different, but reproducible patterns of inhomogeneous RMW distribution (Figure) with a significant decreased septal-to-lateral wall ratio of RMW in DDD mode compared to AAI, both in the FDG-uptake (0.87 ± 0.09 vs 1.05 ± 0.15, resp., p=0.005) and pressure-strain loops area (0.22 ± 0.18 vs 0.94 ± 0.23, resp., p=0.0001). A significant correlation was found between both measures (r=0.584, p=0.018). Conclusions: Our study indicates that RMW can be measured with both regional FDG-uptake and the area of regional pressure-strain loops. The influence of motion and partial volume on the reconstructed FDG-uptake in the asymmetrically remodelled hearts is currently being investigated.

Published
2015
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