35 results on '"Kurtzer I"'
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2. Feedback responses rapidly scale with the urgency to correct for external perturbations
- Author
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UCL - SST/ICTM/INMA - Pôle en ingénierie mathématique, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Crevecoeur, Frédéric, Kurtzer, I., Bourke, T., Scott, S. H., UCL - SST/ICTM/INMA - Pôle en ingénierie mathématique, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Crevecoeur, Frédéric, Kurtzer, I., Bourke, T., and Scott, S. H.
- Abstract
Healthy subjects can easily produce voluntary actions at different speeds and with varying accuracy requirements. It remains unknown whether rapid corrective responses to mechanical perturbations also possess this flexibility and, thereby, contribute to the capability expressed in voluntary control. Paralleling previous studies on self-initiated movements, we examined how muscle activity was impacted by either implicit or explicit criteria affecting the urgency to respond to the perturbation. Participants maintained their arm position against torque perturbations with unpredictable timing and direction. In the first experiment, the urgency to respond was explicitly altered by varying the time limit (300 ms vs. 700 ms) to return to a small target. A second experiment addresses implicit urgency criteria by varying the radius of the goal target, such that task accuracy could be achieved with less vigorous corrections for large targets than small target. We show that muscle responses at ∼60 ms scaled with the task demand. Moreover, in both experiments, we found a strong intertrial correlation between long-latency responses (∼50-100 ms) and the movement reversal times, which emphasizes that these rapid motor responses are directly linked to behavioral performance. The slopes of these linear regressions were sensitive to the experimental condition during the long-latency and early voluntary epochs. These findings suggest that feedback gains for very rapid responses are flexibly scaled according to task-related urgency.
- Published
- 2013
3. Control of position and movement is simplified by combined muscle spindle and Golgi tendon organ feedback
- Author
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Kistemaker, D.A., van Soest, A.J., Wong, J.D., Kurtzer, I, Gribble, P.L., Kistemaker, D.A., van Soest, A.J., Wong, J.D., Kurtzer, I, and Gribble, P.L.
- Abstract
Whereas muscle spindles play a prominent role in current theories of human motor control, Golgi tendon organs (GTO) and their associated tendons are often neglected. This is surprising since there is ample evidence that both tendons and GTOs contribute importantly to neuromusculoskeletal dynamics. Using detailed musculoskeletal models, we provide evidence that simple feedback using muscle spindles alone results in very poor control of joint position and movement since muscle spindles cannot sense changes in tendon length that occur with changes in muscle force. We propose that a combination of spindle and GTO afferents can provide an estimate of muscle-tendon complex length, which can be effectively used for low-level feedback during both postural and movement tasks. The feasibility of the proposed scheme was tested using detailed musculoskeletal models of the human arm. Responses to transient and static perturbations were simulated using a 1-degree-of-freedom (DOF) model of the arm and showed that the combined feedback enabled the system to respond faster, reach steady state faster, and achieve smaller static position errors. Finally, we incorporated the proposed scheme in an optimally controlled 2-DOF model of the arm for fast point-to-point shoulder and elbow movements. Simulations showed that the proposed feedback could be easily incorporated in the optimal control framework without complicating the computation of the optimal control solution, yet greatly enhancing the system's response to perturbations. The theoretical analyses in this study might furthermore provide insight about the strong physiological couplings found between muscle spindle and GTO afferents in the human nervous system. © 2013 the American Physiological Society.
- Published
- 2013
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4. Fast corrective responses are evoked by perturbations approaching the natural variability of posture and movement tasks
- Author
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Crevecoeur, F., primary, Kurtzer, I., additional, and Scott, S. H., additional
- Published
- 2012
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5. Temporal Encoding of Movement in Motor Cortical Neurons
- Author
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Pruszynski, J. A., primary, Coderre, A. M., additional, Lillicrap, T. P., additional, and Kurtzer, I., additional
- Published
- 2007
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6. Feedback responses rapidly scale with the urgency to correct for external perturbations.
- Author
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Crevecoeur, F., Kurtzer, I., Bourke, T., and Scott, S. H.
- Subjects
- *
PSYCHOLOGICAL feedback , *VOLUNTEER service , *MUSCLE physiology , *TASK analysis , *REFLEXES , *MOTOR ability - Abstract
Healthy subjects can easily produce voluntary actions at different speeds and with varying accuracy requirements. It remains unknown whether rapid corrective responses to mechanical perturbations also possess this flexibility and, thereby, contribute to the capability expressed in voluntary control. Paralleling previous studies on self-initiated movements, we examined how muscle activity was impacted by either implicit or explicit criteria affecting the urgency to respond to the perturbation. Participants maintained their arm position against torque perturbations with unpredictable timing and direction. In the first experiment, the urgency to respond was explicitly altered by varying the time limit (300 ms vs. 700 ms) to return to a small target. A second experiment addresses implicit urgency criteria by varying the radius of the goal target, such that task accuracy could be achieved with less vigorous corrections for large targets than small target. We show that muscle responses at ~60 ms scaled with the task demand. Moreover, in both experiments, we found a strong intertrial correlation between long-latency responses (~50-100 ms) and the movement reversal times, which emphasizes that these rapid motor responses are directly linked to behavioral performance. The slopes of these linear regressions were sensitive to the experimental condition during the long-latency and early voluntary epochs. These findings suggest that feedback gains for very rapid responses are flexibly scaled according to task-related urgency. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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- View/download PDF
7. Predictive posture stabilization before contact with moving objects: equivalence of smooth pursuit tracking and peripheral vision.
- Author
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Sinha O, Rosenquist T, Fedorshak A, Kpankpa J, Albenze E, T Bonnet C, Bertucco M, Kurtzer I, and Singh T
- Subjects
- Humans, Male, Female, Adult, Young Adult, Fixation, Ocular physiology, Anticipation, Psychological physiology, Postural Balance physiology, Posture physiology, Visual Fields physiology, Pursuit, Smooth physiology, Motion Perception physiology
- Abstract
Postural stabilization is essential to effectively interact with our environment. Humans preemptively adjust their posture to counteract impending disturbances, such as those encountered during interactions with moving objects, a phenomenon known as anticipatory postural adjustments (APAs). APAs are thought to be influenced by predictive models that incorporate object motion via retinal motion and extraretinal signals. Building on our previous work that examined APAs in relation to the perceived momentum of moving objects, here we explored the impact of object motion within different visual field sectors on the human capacity to anticipate motion and prepare APAs for contact between virtual moving objects and the limb. Participants interacted with objects moving toward them under different gaze conditions. In one condition, participants fixated on either a central point (central fixation) or left-right of the moving object (peripheral fixation), whereas in another, they followed the moving object with smooth pursuit eye movements (SPEMs). We found that APAs had the smallest magnitude in the central fixation condition and that no notable differences in APAs were apparent between the SPEM and peripheral fixation conditions. This suggests that the visual system can accurately perceive motion of objects in peripheral vision for posture stabilization. Using Bayesian model averaging, we also evaluated the contribution of different gaze variables, such as eye velocity and gain (ratio of eye and object velocity) and showed that both eye velocity and gain signals were significant predictors of APAs. Taken together, our study underscores the roles of oculomotor signals in the modulation of APAs. NEW & NOTEWORTHY We show that the human visuomotor system can detect motion in peripheral vision and make anticipatory adjustments to posture before contact with moving objects, just as effectively as when the eye movement system tracks those objects with smooth pursuit eye movements. These findings pave the way for research into how age-induced changes in spatial vision, eye movements, and motion perception could affect the control of limb movements and postural stability during motion-mediated interactions with objects.
- Published
- 2024
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8. Superior performance by two new methods in identifying the online reaction time of reaching movements.
- Author
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Tanis D and Kurtzer I
- Subjects
- Humans, Male, Adult, Female, Movement physiology, Young Adult, Reaction Time physiology, Psychomotor Performance physiology
- Abstract
Reaching movements can be redirected during their progress to handle unexpected visual changes, such as a change in target location. It is important to know when these redirections start, i.e., the online reaction time (oRT), but this information is not readily evident since redirections are embedded within a time-varying baseline movement that differs from trial to trial. The one previous study that evaluated the performance of different oRT identification methods utilized simulated redirections with the exact same onset, rather than a range of onsets as would be typically encountered. We addressed this gap by utilizing batches of "hybrid" trials with temporal spread in their oRTs. Each hybrid trial combined a sampled baseline movement with an idealized corrective response. Two new methods had the most accurate identification of online reaction times: 1 ) a threshold-aligned grand mean regression, and 2 ) a template-based approach we term the canonical correction search. The threshold-aligned grand mean regression is simple to implement and effective. The canonical correction search is a more complex procedure but arguably better linked to the underlying response. Applying the two methods to a published dataset revealed more delayed oRTs than was previously reported along with new information such as the width of oRT distributions. Taken together, our results demonstrate the utility of two new methods for dissecting corrective action from ongoing movement. NEW & NOTEWORTHY Advancing our understanding of visual feedback control requires methods that accurately identify the onset of corrective action. We developed a modified regression approach and a template-based approach to identify the online reaction time of single-reaching movements. Both outperform previous methods when challenged by temporal jitter in the response onset and increased background noise.
- Published
- 2024
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9. Smooth pursuit eye movements contribute to anticipatory force control during mechanical stopping of moving objects.
- Author
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Sinha O, Madarshahian S, Gómez-Granados A, Paine ML, Kurtzer I, and Singh T
- Subjects
- Humans, Aged, Pursuit, Smooth, Eye Movements, Psychomotor Performance physiology, Hand physiology, Nervous System Diseases, Motion Perception physiology
- Abstract
When stopping a closing door or catching an object, humans process the motion of inertial objects and apply reactive limb force over short period to interact with them. One way in which the visual system processes motion is through extraretinal signals associated with smooth pursuit eye movements (SPEMs). We conducted three experiments to investigate how SPEMs contribute to anticipatory and reactive hand force modulation when interacting with a virtual object moving in the horizontal plane. We hypothesized that SPEM signals are critical for timing motor responses, anticipatory control of hand force, and task performance. Participants held a robotic manipulandum and attempted to stop an approaching simulated object by applying a force impulse (area under force-time curve) that matched the object's virtual momentum upon contact. We manipulated the object's momentum by varying either its virtual mass or its speed under free gaze or constrained gaze conditions. We examined gaze variables, the timing of hand motor responses, anticipatory force control, and overall task performance. Our results show that when participants were fixated at a designated location instead of following objects with SPEM, anticipatory modulation of hand force before contact decreased. However, constraining gaze by asking participants to fixate did not seem to affect the timing of the motor response or the task performance. Together, these results suggest that SPEMs may be important for anticipatory control of hand force before contact and may also play a critical role in anticipatory stabilization of limb posture when humans interact with moving objects. NEW & NOTEWORTHY We show for the first time that smooth pursuit eye movements (SPEMs) play a role in the modulation of anticipatory control of hand force to stabilize posture against contact forces. SPEMs are critical for tracking moving objects, facilitate processing motion of moving objects, and are impacted during aging and in many neurological disorders, such as Alzheimer's disease and multiple sclerosis. These results provide a novel basis to probe how changes in SPEMs could contribute to deficient limb motor control in older adults and patients with neurological disorders.
- Published
- 2023
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10. Object motion influences feedforward motor responses during mechanical stopping of virtual projectiles: a preliminary study.
- Author
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Gómez-Granados A, Kurtzer I, Gordon S, Barany DA, and Singh T
- Subjects
- Humans, Psychomotor Performance physiology, Learning, Motion, Hand Strength physiology, Hand physiology
- Abstract
An important window into sensorimotor function is how humans interact and stop moving projectiles, such as stopping a door from closing shut or catching a ball. Previous studies have suggested that humans time the initiation and modulate the amplitude of their muscle activity based on the momentum of the approaching object. However, real-world experiments are constrained by laws of mechanics, which cannot be manipulated experimentally to probe the mechanisms of sensorimotor control and learning. An augmented-reality variant of such tasks allows for experimental manipulation of the relationship between motion and force to obtain novel insights into how the nervous system prepares motor responses to interact with moving stimuli. Existing paradigms for studying interactions with moving projectiles use massless objects and are primarily focused on quantifying gaze and hand kinematics. Here, we developed a novel collision paradigm using a robotic manipulandum where participants mechanically stopped a virtual object moving in the horizontal plane. On each block of trials, we varied the virtual object's momentum by increasing either its velocity or mass. Participants stopped the object by applying a force impulse that matched the object momentum. We observed that hand force increased as a function of object momentum linked to changes in virtual mass or velocity, similar to results from studies involving catching free-falling objects. In addition, increasing object velocity resulted in later onset of hand force relative to the impending time-to-contact. These findings show that the present paradigm can be used to determine how humans process projectile motion for hand motor control., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
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11. Anticipatory weight shift between arms when reaching from a crouched posture.
- Author
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Gallagher R, Perez S, DeLuca D, and Kurtzer I
- Subjects
- Adult, Biomechanical Phenomena, Electromyography, Humans, Young Adult, Anticipation, Psychological physiology, Motor Activity physiology, Muscle, Skeletal physiology, Postural Balance physiology, Posture physiology, Psychomotor Performance physiology
- Abstract
Reaching movements performed from a crouched body posture require a shift of body weight from both arms to one arm. This situation has remained unexamined despite the analogous load requirements during step initiation and the many studies of reaching from a seated or standing posture. To determine whether the body weight shift involves anticipatory or exclusively reactive control, we obtained force plate records, hand kinematics, and arm muscle activity from 11 healthy right-handed participants. They performed reaching movements with their left and right arm in two speed contexts, "comfortable" and "as fast as possible," and two postural contexts, a less stable knees-together posture and a more stable knees-apart posture. Weight-shifts involved anticipatory postural actions (APAs) by the reaching and stance arms that were opposing in the vertical axis and aligned in the side-to-side axis similar to APAs by the legs for step initiation. Weight-shift APAs were correlated in time and magnitude, present in both speed contexts, more vigorous with the knees placed together, and similar when reaching with the dominant and nondominant arm. The initial weight-shift was preceded by bursts of muscle activity in the shoulder and elbow extensors (posterior deltoid and triceps lateral) of the reach arm and shoulder flexor (pectoralis major) of the stance arm, which indicates their causal role; leg muscles may have indirectly contributed but were not recorded. The strong functional similarity of weight-shift APAs during crouched reaching to human stepping and cat reaching suggests that they are a core feature of posture-movement coordination. NEW & NOTEWORTHY This work demonstrates that reaching from a crouched posture is preceded by bimanual anticipatory postural adjustments (APAs) that shift the body weight to the stance limb. Weight-shift APAs are more robust in an unstable body posture (knees together) and involve the shoulder and elbow extensors of the reach arm and shoulder flexor of the stance arm. This pattern mirrors the forelimb coordination of cats reaching and humans initiating a step.
- Published
- 2021
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12. Similar stretch reflexes and behavioral patterns are expressed by the dominant and nondominant arms during postural control.
- Author
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Maurus P, Kurtzer I, Antonawich R, and Cluff T
- Subjects
- Adult, Arm innervation, Female, Humans, Joints physiology, Male, Motor Skills, Muscle, Skeletal physiology, Torque, Arm physiology, Functional Laterality, Postural Balance, Reflex, Stretch
- Abstract
Limb dominance is evident in many daily activities, leading to the prominent idea that each hemisphere of the brain specializes in controlling different aspects of movement. Past studies suggest that the dominant arm is primarily controlled via an internal model of limb dynamics that enables the nervous system to produce efficient movements. In contrast, the nondominant arm may be primarily controlled via impedance mechanisms that rely on the strong modulation of sensory feedback from individual joints to control limb posture. We tested whether such differences are evident in behavioral responses and stretch reflexes following sudden displacement of the arm during posture control. Experiment 1 applied specific combinations of elbow-shoulder torque perturbations (the same for all participants). Peak joint displacements, return times, end point accuracy, and the directional tuning and amplitude of stretch reflexes in nearly all muscles were not statistically different between the two arms. Experiment 2 induced specific combinations of joint motion (the same for all participants). Again, peak joint displacements, return times, end point accuracy, and the directional tuning and amplitude of stretch reflexes in nearly all muscles did not differ statistically when countering the imposed loads with each arm. Moderate to strong correlations were found between stretch reflexes and behavioral responses to the perturbations with the two arms across both experiments. Collectively, the results do not support the idea that the dominant arm specializes in exploiting internal models and the nondominant arm in impedance control by increasing reflex gains to counter sudden loads imposed on the arms during posture control. NEW & NOTEWORTHY A prominent hypothesis is that the nervous system controls the dominant arm through predictive internal models and the nondominant arm through impedance mechanisms. We tested whether stretch reflexes of muscles in the two arms also display such specialization during posture control. Nearly all behavioral responses and stretch reflexes did not differ statistically but were strongly correlated between the arms. The results indicate individual signatures of feedback control that are common for the two arms.
- Published
- 2021
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13. Interjoint coupling of position sense reflects sensory contributions of biarticular muscles.
- Author
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Herter TM, Kurtzer I, Granat L, Crevecoeur F, Dukelow SP, and Scott SH
- Subjects
- Adult, Aged, Female, Hand physiology, Humans, Male, Middle Aged, Muscle Spindles physiology, Young Adult, Models, Biological, Muscle, Skeletal physiology, Proprioception physiology, Psychomotor Performance physiology, Upper Extremity physiology
- Abstract
Perception of limb position and motion combines sensory information from spindles in muscles that span one joint (monoarticulars) and two joints (biarticulars). This anatomical organization should create interactions in estimating limb position. We developed two models, one with only monoarticulars and one with both monoarticulars and biarticulars, to explore how biarticulars influence estimates of arm position in hand ( x , y ) and joint ( shoulder, elbow ) coordinates. In hand coordinates, both models predicted larger medial-lateral than proximal-distal errors, although the model with both muscle groups predicted that biarticulars would reduce this bias. In contrast, the two models made significantly different predictions in joint coordinates. The model with only monoarticulars predicted that errors would be uniformly distributed because estimates of angles at each joint would be independent. In contrast, the model that included biarticulars predicted that errors would be coupled between the two joints, resulting in smaller errors for combinations of flexion or extension at both joints and larger errors for combinations of flexion at one joint and extension at the other joint. We also carried out two experiments to examine errors made by human subjects during an arm position matching task in which a robot passively moved one arm to different positions and the subjects moved their other arm to mirror-match each position. Errors in hand coordinates were similar to those predicted by both models. Critically, however, errors in joint coordinates were only similar to those predicted by the model with monoarticulars and biarticulars. These results highlight how biarticulars influence perceptual estimates of limb position by helping to minimize medial-lateral errors. NEW & NOTEWORTHY It is unclear how sensory information from muscle spindles located within muscles spanning multiple joints influences perception of body position and motion. We address this issue by comparing errors in estimating limb position made by human subjects with predicted errors made by two musculoskeletal models, one with only monoarticulars and one with both monoarticulars and biarticulars. We provide evidence that biarticulars produce coupling of errors between joints, which help to reduce errors.
- Published
- 2021
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14. Spinal Circuits Mediate a Stretch Reflex Between the Upper Limbs in Humans.
- Author
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Muraoka T and Kurtzer I
- Subjects
- Electromyography, Humans, Muscle, Skeletal, Reflex, Shoulder, Torque, Reflex, Stretch, Upper Extremity
- Abstract
Inter-limb reflexes play an important role in coordinating behaviors involving different limbs. Previous studies have demonstrated that human elbow muscles express an inter-limb stretch reflex at long-latency (50-100 ms), a timing consistent with a trans-cortical linkage. Here we probe for inter-limb stretch reflexes in the shoulder muscles of human participants. Unexpected torque pulses displaced one or both shoulders while participants adopted a steady posture against background torques. The results demonstrated inter-limb stretch reflexes occurring at short-latency for both shoulder extensors and flexors; the rapid timing (36-50 ms) must involve a spinal linkage for the two arms. Inter-limb stretch reflexes were also observed at long-latency yet they were opposite to the preceding short-latency; when the short-latency stretch reflex was excitatory then the long-latency stretch reflex was inhibitory and vice versa. Comparing the responses to contralateral arm displacement to those during simultaneous displacement of both arms revealed that inhibitory inter-limb stretch reflexes are independent of within-limb stretch reflexes, but that excitatory inter-limb stretch reflexes are suppressed by within-limb stretch reflexes. Our results provide the first demonstration of short-latency inter-limb stretch reflexes in the upper limb of humans and reveal interacting spinal circuits for within-limb and inter-limb stretch reflexes., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2020
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15. Long-latency reflexes for inter-effector coordination reflect a continuous state feedback controller.
- Author
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Crevecoeur F and Kurtzer I
- Subjects
- Animals, Humans, Motor Activity, Muscle, Skeletal innervation, Muscle, Skeletal physiology, Reaction Time, Feedback, Physiological, Reflex
- Abstract
Successful performance in many everyday tasks requires compensating unexpected mechanical disturbance to our limbs and body. The long-latency reflex plays an important role in this process because it is the fastest response to integrate sensory information across several effectors, like when linking the elbow and shoulder or the arm and body. Despite the dozens of studies on inter-effector long-latency reflexes, there has not been a comprehensive treatment of how these reveal the basic control organization that sets constraints on any candidate model of neural feedback control such as optimal feedback control. We considered three contrasting ways that controllers can be organized: multiple independent controllers vs. a multiple-input multiple-output (MIMO) controller, a continuous feedback controller vs. an intermittent feedback controller, and a direct MIMO controller vs. a state feedback controller. Following a primer on control theory and review of the relevant evidence, we conclude that continuous state feedback control best describes the organization of inter-effector coordination by the long-latency reflex.
- Published
- 2018
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16. Variable impact of tizanidine on the medium latency reflex of upper and lower limbs.
- Author
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Kurtzer I, Bouyer LJ, Bouffard J, Jin A, Christiansen L, Nielsen JB, and Scott SH
- Subjects
- Adult, Clonidine pharmacology, Electromyography, Female, Humans, Interneurons drug effects, Male, Motor Neurons drug effects, Neurons, Afferent drug effects, Robotics, Young Adult, Adrenergic alpha-2 Receptor Agonists pharmacology, Afferent Pathways drug effects, Clonidine analogs & derivatives, Lower Extremity physiology, Motor Activity drug effects, Muscle, Skeletal drug effects, Reflex drug effects, Upper Extremity physiology
- Abstract
Sudden limb displacement evokes a complex sequence of compensatory muscle activity. Following the short-latency reflex and preceding voluntary reactions is an epoch termed the medium-latency reflex (MLR) that could reflect spinal processing of group II muscle afferents. One way to test this possibility is oral ingestion of tizanidine, an alpha-2 adrenergic agonist that inhibits the interneurons transmitting group II signals onto spinal motor neurons. We examined whether group II afferents contribute to MLR activity throughout the major muscles that span the elbow and shoulder. MLRs of ankle muscles were also tested during walking on the same day, in the same participants as well as during sitting in a different group of subjects. In contrast to previous reports, the ingestion of tizanidine had minimal impact on MLRs of arm or leg muscles during motor actions. A significant decrease in magnitude was observed for 2/16 contrasts in arm muscles and 0/4 contrasts in leg muscles. This discrepancy with previous studies could indicate that tizanidine's efficacy is altered by subtle changes in protocol or that group II afferents do not substantially contribute to MLRs.
- Published
- 2018
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17. Long-latency reflexes of elbow and shoulder muscles suggest reciprocal excitation of flexors, reciprocal excitation of extensors, and reciprocal inhibition between flexors and extensors.
- Author
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Kurtzer I, Meriggi J, Parikh N, and Saad K
- Subjects
- Action Potentials, Adult, Female, Humans, Male, Movement, Muscle, Skeletal innervation, Neural Inhibition, Posture, Reaction Time, Elbow physiology, Muscle, Skeletal physiology, Reflex, Shoulder physiology
- Abstract
Postural corrections of the upper limb are required in tasks ranging from handling an umbrella in the changing wind to securing a wriggling baby. One complication in this process is the mechanical interaction between the different segments of the arm where torque applied at one joint induces motion at multiple joints. Previous studies have shown the long-latency reflexes of shoulder muscles (50-100 ms after a limb perturbation) account for these mechanical interactions by integrating information about motion of both the shoulder and elbow. It is less clear whether long-latency reflexes of elbow muscles exhibit a similar capability and what is the relation between the responses of shoulder and elbow muscles. The present study utilized joint-based loads tailored to the subjects' arm dynamics to induce well-controlled displacements of their shoulder and elbow. Our results demonstrate that the long-latency reflexes of shoulder and elbow muscles integrate motion from both joints: the shoulder and elbow flexors respond to extension at both joints, whereas the shoulder and elbow extensors respond to flexion at both joints. This general pattern accounts for the inherent flexion-extension coupling of the two joints arising from the arm's intersegmental dynamics and is consistent with spindle-based reciprocal excitation of shoulder and elbow flexors, reciprocal excitation of shoulder and elbow extensors, and across-joint inhibition between the flexors and extensors., (Copyright © 2016 the American Physiological Society.)
- Published
- 2016
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18. Fast feedback control involves two independent processes utilizing knowledge of limb dynamics.
- Author
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Kurtzer I, Crevecoeur F, and Scott SH
- Subjects
- Adult, Female, Humans, Male, Feedback, Physiological, Movement physiology, Muscle, Skeletal physiology, Upper Extremity physiology
- Abstract
Corrective muscle responses occurring 50-100 ms after a mechanical perturbation are tailored to the mechanical features of the limb and its environment. For example, the evoked response by the shoulder's extensor muscle counters an imposed shoulder torque, rather than local shoulder motion, by integrating motion information from the shoulder and elbow appropriate for their dynamic interaction. Previous studies suggest that arm muscle activity within this epoch, alternately termed the R2/3 response, or long-latency reflex, reflects the summed result of two distinct components: an activity-dependent component which scales with the background muscle activity, and a task-dependent component which scales with the required vigor of the behavioral task. Here we examine how the knowledge of limb dynamics expressed during the shoulder muscle's R2/3 epoch is related to these two functional components. Subjects countered torque steps applied to their shoulder and/or elbow under different conditions of background torque and target size to recruit the activity-dependent and task-dependent component in varying degrees. Experiment 1 involved four torque perturbations, two levels of background torques and two target sizes; this design revealed that both background torque and target size impacted the shoulder's R2/3 activity, indicative of knowledge of limb dynamics. Experiment 2 involved two perturbation torques, five levels of background torque and two target sizes; this design demonstrated that the two factors had an independent impact on the R2/3 activity indicative of knowledge of limb dynamics. We conclude that a sophisticated feature of upper limb feedback control reflects the summation of two processes having a common capability.
- Published
- 2014
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19. Cerebellar damage diminishes long-latency responses to multijoint perturbations.
- Author
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Kurtzer I, Trautman P, Rasquinha RJ, Bhanpuri NH, Scott SH, and Bastian AJ
- Subjects
- Adult, Aged, Case-Control Studies, Cerebellum, Feedback, Physiological, Humans, Joints innervation, Middle Aged, Motion, Movement, Muscle, Skeletal innervation, Torque, Upper Extremity innervation, Upper Extremity physiopathology, Cerebellar Ataxia physiopathology, Joints physiopathology, Muscle, Skeletal physiopathology, Reaction Time
- Abstract
Damage to the cerebellum can cause significant problems in the coordination of voluntary arm movements. One prominent idea is that incoordination stems from an inability to predictively account for the complex mechanical interactions between the arm's several joints. Motivated by growing evidence that corrective feedback control shares important capabilities and neural substrates with feedforward control, we asked whether cerebellar damage impacts feedback stabilization of the multijoint arm appropriate for the arm's intersegmental dynamics. Specifically, we tested whether cerebellar dysfunction impacts the ability of posterior deltoid to incorporate elbow motion in its long-latency response (R2 = 45-75 ms and R3 = 75-100 ms after perturbation) to an unexpected torque perturbation. Healthy and cerebellar-damaged subjects were exposed to a selected pattern of shoulder-elbow displacements to probe the response pattern from this shoulder extensor muscle. The healthy elderly subjects expressed a long-latency response linked to both shoulder and elbow motion, including an increase/decrease in shoulder extensor activity with elbow flexion/extension. Critically, cerebellar-damaged subjects displayed the normal pattern of activity in the R3 period indicating an intact ability to rapidly integrate multijoint motion appropriate to the arm's intersegmental dynamics. However, cerebellar-damaged subjects had a lower magnitude of activity that was specific to the long-latency period (both R2 and R3) and a slightly delayed onset of multijoint sensitivity. Taken together, our results suggest that the basic motor pattern of the long-latency response is housed outside the cerebellum and is scaled by processes within the cerebellum.
- Published
- 2013
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20. Control of position and movement is simplified by combined muscle spindle and Golgi tendon organ feedback.
- Author
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Kistemaker DA, Van Soest AJ, Wong JD, Kurtzer I, and Gribble PL
- Subjects
- Afferent Pathways physiology, Arm physiology, Humans, Male, Models, Biological, Muscle, Skeletal physiology, Posture, Tendons physiology, Feedback, Sensory, Mechanoreceptors physiology, Movement, Muscle Spindles physiology, Muscle, Skeletal innervation, Tendons innervation
- Abstract
Whereas muscle spindles play a prominent role in current theories of human motor control, Golgi tendon organs (GTO) and their associated tendons are often neglected. This is surprising since there is ample evidence that both tendons and GTOs contribute importantly to neuromusculoskeletal dynamics. Using detailed musculoskeletal models, we provide evidence that simple feedback using muscle spindles alone results in very poor control of joint position and movement since muscle spindles cannot sense changes in tendon length that occur with changes in muscle force. We propose that a combination of spindle and GTO afferents can provide an estimate of muscle-tendon complex length, which can be effectively used for low-level feedback during both postural and movement tasks. The feasibility of the proposed scheme was tested using detailed musculoskeletal models of the human arm. Responses to transient and static perturbations were simulated using a 1-degree-of-freedom (DOF) model of the arm and showed that the combined feedback enabled the system to respond faster, reach steady state faster, and achieve smaller static position errors. Finally, we incorporated the proposed scheme in an optimally controlled 2-DOF model of the arm for fast point-to-point shoulder and elbow movements. Simulations showed that the proposed feedback could be easily incorporated in the optimal control framework without complicating the computation of the optimal control solution, yet greatly enhancing the system's response to perturbations. The theoretical analyses in this study might furthermore provide insight about the strong physiological couplings found between muscle spindle and GTO afferents in the human nervous system.
- Published
- 2013
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21. Primary motor cortex underlies multi-joint integration for fast feedback control.
- Author
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Pruszynski JA, Kurtzer I, Nashed JY, Omrani M, Brouwer B, and Scott SH
- Subjects
- Adult, Animals, Biomechanical Phenomena physiology, Evoked Potentials, Motor physiology, Female, Humans, Macaca mulatta, Male, Motor Neurons physiology, Muscle, Skeletal physiology, Time Factors, Elbow physiology, Feedback, Sensory physiology, Motor Cortex cytology, Motor Cortex physiology, Shoulder physiology
- Abstract
A basic difficulty for the nervous system is integrating locally ambiguous sensory information to form accurate perceptions about the outside world. This local-to-global problem is also fundamental to motor control of the arm, because complex mechanical interactions between shoulder and elbow allow a particular amount of motion at one joint to arise from an infinite combination of shoulder and elbow torques. Here we show, in humans and rhesus monkeys, that a transcortical pathway through primary motor cortex (M1) resolves this ambiguity during fast feedback control. We demonstrate that single M1 neurons of behaving monkeys can integrate shoulder and elbow motion information into motor commands that appropriately counter the underlying torque within about 50 milliseconds of a mechanical perturbation. Moreover, we reveal a causal link between M1 processing and multi-joint integration in humans by showing that shoulder muscle responses occurring ∼50 milliseconds after pure elbow displacement can be potentiated by transcranial magnetic stimulation. Taken together, our results show that transcortical processing through M1 permits feedback responses to express a level of sophistication that rivals voluntary control; this provides neurophysiological support for influential theories positing that voluntary movement is generated by the intelligent manipulation of sensory feedback.
- Published
- 2011
- Full Text
- View/download PDF
22. The long-latency reflex is composed of at least two functionally independent processes.
- Author
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Pruszynski JA, Kurtzer I, and Scott SH
- Subjects
- Adult, Biomechanical Phenomena physiology, Electromyography, Female, Humans, Male, Motor Activity physiology, Muscle, Skeletal physiology, Upper Extremity physiology, Young Adult, Feedback, Physiological, Reaction Time, Reflex physiology
- Abstract
The nervous system counters mechanical perturbations applied to the arm with a stereotypical sequence of muscle activity, starting with the short-latency stretch reflex and ending with a voluntary response. Occurring between these two events is the enigmatic long-latency reflex. Although researchers have been fascinated by the long-latency reflex for over 60 years, some of the most basic questions about this response remain unresolved and often debated. In the present study we help resolve one such question by providing clear evidence that the human long-latency reflex during a naturalistic motor task is not a single functional response; rather, it appears to reflect the output of (at least) two functionally independent processes that overlap in time and sum linearly. One of these functional components shares an important attribute of the short-latency reflex (i.e., automatic gain scaling, sensitivity to background load), and the other shares a defining feature of voluntary control (i.e., task dependency, sensitivity to goal target position). We further show that the task-dependent component of long-latency activity reflects a feedback control process rather than the simplest triggered reaction to a mechanical stimulus.
- Published
- 2011
- Full Text
- View/download PDF
23. Long-latency and voluntary responses to an arm displacement can be rapidly attenuated by perturbation offset.
- Author
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Kurtzer I, Pruszynski JA, and Scott SH
- Subjects
- Adult, Arm innervation, Elbow Joint innervation, Elbow Joint physiology, Electromyography methods, Feedback, Physiological physiology, Female, Humans, Male, Mechanical Phenomena, Movement physiology, ROC Curve, Time Factors, Torque, Arm physiology, Muscle, Skeletal physiology, Reaction Time physiology, Reflex, Stretch physiology
- Abstract
Feedback control of our limbs must account for the unexpected offset of mechanical perturbations. Here we examine the evoked activity of elbow flexor and extensor muscles to torque pulses lasting 22-152 ms and how torque offset impacts activity in the long-latency (45-100 ms) and voluntary epochs (120-180 ms). For each pulse width, we found a significant attenuation of muscle activity approximately 30 ms after the offset of torque compared with when the torque was sustained. The brief time between the offset of torque and the attenuation of muscle activity implicates group I afferents acting through a spinal pathway, because this route is the only one fast enough and short enough to be responsible. Moreover, elbow muscle activity in the subsequent 20-45 ms following torque-offset was approximately 35% smaller than when the torque was sustained. These results show that a fast spinal process can powerfully attenuate corrective responses of the arm to a torque perturbation.
- Published
- 2010
- Full Text
- View/download PDF
24. Long-latency responses during reaching account for the mechanical interaction between the shoulder and elbow joints.
- Author
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Kurtzer I, Pruszynski JA, and Scott SH
- Subjects
- Adult, Biomechanical Phenomena, Electromyography, Feedback, Physiological physiology, Female, Humans, Male, Muscle Contraction physiology, Muscle, Skeletal physiology, Torque, Young Adult, Elbow Joint physiology, Mechanical Phenomena, Movement physiology, Psychomotor Performance physiology, Reaction Time physiology, Shoulder Joint physiology
- Abstract
Although considerable research indicates that reaching movements rely on knowledge of the arm's mechanical properties and environment to anticipate and counter predictable loads, far less research has examined whether this degree of sophistication is present for on-line corrections during reaching. Here we examine the R2/3 response to mechanical perturbations (45-100 ms, also called the long-latency reflex), which is highly flexible and includes the fastest possible contribution from primary motor cortex, a key neural substrate for self-initiated action. Torque perturbations were occasionally and unexpectedly applied to the subject's shoulder and/or elbow in the course of performing reaching movements. Critically, these perturbations would evoke different patterns of feedback corrections from a shoulder extensor muscle if it countered only the local shoulder displacement relative to unperturbed motion or accounted for the mechanical interactions between the shoulder and elbow joints and countered the underlying shoulder torque. Our results show that the earliest response (R1: 20-45 ms) reflected local shoulder displacement, whereas the R2/3 response (45-100 ms) reflected knowledge of multijoint dynamics. Moreover, the same pattern of feedback occurred whether the shoulder muscle helped initiate the movement (during its agonist phase) or helped terminate the movement (during its antagonist phase). These results contribute to the accumulating evidence that highly sophisticated feedback control underlies motor behavior and are consistent with a shared neural substrate, such as primary motor cortex, for feedforward and feedback control.
- Published
- 2009
- Full Text
- View/download PDF
25. Temporal evolution of "automatic gain-scaling".
- Author
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Pruszynski JA, Kurtzer I, Lillicrap TP, and Scott SH
- Subjects
- Analysis of Variance, Biomechanical Phenomena, Elasticity, Electromyography, Hand, Humans, Regression Analysis, Time Factors, Elbow physiology, Models, Biological, Motor Activity physiology, Muscle, Skeletal physiology
- Abstract
The earliest neural response to a mechanical perturbation, the short-latency stretch response (R1: 20-45 ms), is known to exhibit "automatic gain-scaling" whereby its magnitude is proportional to preperturbation muscle activity. Because gain-scaling likely reflects an intrinsic property of the motoneuron pool (via the size-recruitment principle), counteracting this property poses a fundamental challenge for the nervous system, which must ultimately counter the absolute change in load regardless of the initial muscle activity (i.e., show no gain-scaling). Here we explore the temporal evolution of gain-scaling in a simple behavioral task where subjects stabilize their arm against different background loads and randomly occurring torque perturbations. We quantified gain-scaling in four elbow muscles (brachioradialis, biceps long, triceps lateral, triceps long) over the entire sequence of muscle activity following perturbation onset-the short-latency response, long-latency response (R2: 50-75 ms; R3: 75-105 ms), early voluntary corrections (120-180 ms), and steady-state activity (750-1250 ms). In agreement with previous observations, we found that the short-latency response demonstrated substantial gain-scaling with a threefold increase in background load resulting in an approximately twofold increase in muscle activity for the same perturbation. Following the short-latency response, we found a rapid decrease in gain-scaling starting in the long-latency epoch ( approximately 75-ms postperturbation) such that no significant gain-scaling was observed for the early voluntary corrections or steady-state activity. The rapid decrease in gain-scaling supports our recent suggestion that long-latency responses and voluntary control are inherently linked as part of an evolving sensorimotor control process through similar neural circuitry.
- Published
- 2009
- Full Text
- View/download PDF
26. Rapid motor responses are appropriately tuned to the metrics of a visuospatial task.
- Author
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Pruszynski JA, Kurtzer I, and Scott SH
- Subjects
- Adult, Biomechanical Phenomena, Electromyography, Female, Humans, Male, Muscle, Skeletal innervation, Muscle, Skeletal physiology, ROC Curve, Reaction Time physiology, Upper Extremity innervation, Eye Movements physiology, Mental Processes physiology, Psychomotor Performance physiology, Reflex physiology, Space Perception physiology
- Abstract
Considerable research has established that rapid motor responses (traditionally called reflexes), can be modified by a subject's voluntary goals. Here, we expand on past observations using verbal instructions by defining the voluntary goal via visual target position. This approach allowed us to objectively enforce task adherence and explore a richer set of variables, such as target direction and distance, metrics that modify voluntary control and that--according to our hypothesis--will influence rapid motor responses. Our first experiment tested whether upper-limb responses are categorically modulated by target direction by placing targets such that the same perturbation could push the hand into one target and out of the other, a spatial analogue to "resist/yield" verbal instructions. Consistent with these classical results, we found that the short-latency rapid response (R1, 20-45 ms) was not modulated by target direction, whereas long-latency rapid responses (R2/R3, 45-105 ms) were modified in a manner approaching the voluntary response (VOL, 120-180 ms). Our second experiment tested whether upper-limb responses are continuously modulated by target distance by distributing five targets along one axis centered on the hand. Here, the long-latency and voluntary response mirrored the task demands by increasing activity in a graded fashion with increasing target distance. Our final experiment explored how upper-limb responses incorporate two-dimensional spatial information by placing targets radially around the hand. Notably, long-latency responses exhibited smooth tuning functions to target direction that were similar to those observed for the voluntary response. Taken together, these results illustrate the flexibility of long-latency rapid responses and emphasize their similarity to later voluntary responses.
- Published
- 2008
- Full Text
- View/download PDF
27. Contrasting interpretations of the nonuniform distribution of preferred directions within primary motor cortex.
- Author
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Kurtzer I and Herter TM
- Subjects
- Animals, Macaca mulatta, Motor Cortex cytology, Motor Neurons physiology, Space Perception physiology, Data Interpretation, Statistical, Motor Cortex physiology, Psychomotor Performance physiology
- Published
- 2007
- Full Text
- View/download PDF
28. Characterization of torque-related activity in primary motor cortex during a multijoint postural task.
- Author
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Herter TM, Kurtzer I, Cabel DW, Haunts KA, and Scott SH
- Subjects
- Algorithms, Animals, Data Interpretation, Statistical, Elbow Joint innervation, Elbow Joint physiology, Electrodes, Implanted, Electromyography, Macaca mulatta, Movement physiology, Muscle, Skeletal innervation, Muscle, Skeletal physiology, Shoulder Joint innervation, Shoulder Joint physiology, Joints innervation, Joints physiology, Motor Cortex physiology, Posture physiology
- Abstract
The present study examined neural activity in the shoulder/elbow region of primary motor cortex (M1) during a whole-limb postural task. By selectively imposing torques at the shoulder, elbow, or both joints we addressed how neurons represent changes in torque at a single joint, multiple joints, and their interrelation. We observed that similar proportions of neurons reflected changes in torque at the shoulder, elbow, and both joints and these neurons were highly intermingled across the cortical surface. Most torque-related neurons were reciprocally excited and inhibited (relative to their unloaded baseline activity) by opposing flexor and extensor torques at a single joint. Although coexcitation/coinhibition was occasionally observed at a single joint, it was rarely observed at both joints. A second analysis assessed the relationship between single-joint and multijoint activity. In contrast to our previous observations, we found that neither linear nor vector summation of single-joint activities could capture the breadth of neural responses to multijoint torques. Finally, we studied the neurons' directional tuning across all the torque conditions, i.e., in joint-torque space. Our population of M1 neurons exhibited a strong bimodal distribution of preferred-torque directions (PTDs) that was biased toward shoulder-extensor/elbow-flexor (whole-limb flexor) and shoulder-flexor/elbow-extensor (whole-limb extensor) torques. Notably, we recently observed a similar bimodal distribution of PTDs in a sample of proximal arm muscles. This observation illustrates the intimate relationship between M1 and the motor periphery.
- Published
- 2007
- Full Text
- View/download PDF
29. A multi-level approach to understanding upper limb function.
- Author
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Kurtzer I and Scott SH
- Subjects
- Animals, Humans, Motor Cortex cytology, Motor Neurons physiology, Muscle, Skeletal physiology, Neural Networks, Computer, Movement physiology, Upper Extremity physiology
- Abstract
Here we describe a multi-level approach to study upper limb control. By using non-human primates we were able to examine several different levels of motor organization within the same individual including their voluntary behavior, musculoskeletal plant, and neural activity. This approach revealed several parallels in the global patterns of activity of upper arm muscles and neurons in primary motor cortex (M1). For example, during postural maintenance both arm muscles and arm-related M1 neurons exhibit a bias in torque-related activity towards whole-limb flexion and whole-limb extension torque. A similar bias could be reproduced with a mathematical model of muscle recruitment that minimized the effects of motor noise suggesting a common constraint for the population activation of muscles and cortical neurons. That said, M1 neurons were not merely "upper motor neurons" as they exhibited substantial context-dependency in torque-related activity compared to arm muscles. This flexible association with low-level processing is consistent with M1 having a pivotal role in an optimal feedback controller.
- Published
- 2007
- Full Text
- View/download PDF
30. Nonuniform distribution of reach-related and torque-related activity in upper arm muscles and neurons of primary motor cortex.
- Author
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Kurtzer I, Herter TM, and Scott SH
- Subjects
- Algorithms, Animals, Data Interpretation, Statistical, Elbow innervation, Elbow physiology, Electromyography, Hand innervation, Hand physiology, Macaca mulatta, Male, Motor Cortex cytology, Movement physiology, Shoulder innervation, Shoulder physiology, Space Perception physiology, Arm innervation, Arm physiology, Motor Cortex physiology, Motor Neurons physiology, Muscle, Skeletal innervation, Neurons physiology
- Abstract
The present study examined the activity of primate shoulder and elbow muscles using a novel reaching task. We enforced similar patterns of center-out movement while the animals countered viscous loads at their shoulder, elbow, both joints, or neither joint. Accordingly, we could examine reach-related activity during the unloaded condition and torque-related activity by comparing activity across load conditions. During unloaded reaching the upper arm muscles exhibited a bimodal distribution of preferred hand direction. Maximal reach-related activity occurred with hand movements mostly toward or away from the body. Arm muscles also exhibited a bimodal distribution of their preferred torque direction. Maximal torque-related activity typically occurred with shoulder-extension/elbow-flexion torque or shoulder-flexion/elbow-extension torque. Similar biases in reach-related and torque-related activity could be reproduced by optimizing a global measure of muscle activity. These biases were also observed in the neural activity of primary motor cortex (M1). The parallels between M1 and muscular activity demonstrate another link between motor cortical processing and the motor periphery and may reflect an optimization process performed by the sensorimotor system.
- Published
- 2006
- Full Text
- View/download PDF
31. Limited transfer of learning between unimanual and bimanual skills within the same limb.
- Author
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Nozaki D, Kurtzer I, and Scott SH
- Subjects
- Adaptation, Physiological physiology, Adult, Arm physiology, Clinical Trials as Topic, Humans, Male, Functional Laterality physiology, Motor Skills physiology, Transfer, Psychology physiology
- Abstract
Although a limb's motion appears to be similar across unimanual and bimanual movements, here we demonstrate partial, but not complete, transfer of learning across these behavioral contexts, hidden learning that remains intact (but invisible) until the original context is again encountered, and the ability to associate two conflicting force fields simultaneously, one with each context. These results suggest partial, but not complete, overlap in the learning processes involved in the acquisition of unimanual and bimanual skills.
- Published
- 2006
- Full Text
- View/download PDF
32. Primate upper limb muscles exhibit activity patterns that differ from their anatomical action during a postural task.
- Author
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Kurtzer I, Pruszynski JA, Herter TM, and Scott SH
- Subjects
- Animals, Electromyography methods, Macaca mulatta, Male, Task Performance and Analysis, Torque, Arm physiology, Motor Skills physiology, Movement physiology, Muscle Contraction physiology, Muscle, Skeletal anatomy & histology, Muscle, Skeletal physiology, Posture physiology
- Abstract
The present study examined muscular activity in the primate proximal forelimb during a posture task. By applying loads selectively to the shoulder, elbow, or both joints, we observed that monoarticular shoulder and elbow muscles varied their activity with loads at the unspanned joint. Shoulder monoarticulars changed activity with elbow torque and elbow monoarticulars changed activity with shoulder torque. Due to this additional modulation, the maximal activation of monoarticular muscles was deviated from their anatomical action toward either shoulder-extension/elbow-flexion or shoulder-flexion/elbow-extension. Biarticular muscles also expressed deviations in their preferred torque direction toward either shoulder-extension/elbow-flexion or shoulder-flexion/elbow-extension. The biased distribution of preferred torque directions in proximal forelimb muscles could be modeled by the minimization of a global measure of muscle activity. Moreover, arm-related neurons of primary motor cortex exhibit a similar bias in preferred torque directions consistent with the intimate relationship between the primary motor cortex and the motor periphery.
- Published
- 2006
- Full Text
- View/download PDF
33. Adaptation to a novel multi-force environment.
- Author
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Kurtzer I, DiZio PA, and Lackner JR
- Subjects
- Adolescent, Adult, Biomechanical Phenomena, Central Nervous System physiology, Female, Gravitation, Humans, Male, Models, Neurological, Psychomotor Performance physiology, Weight-Bearing physiology, Adaptation, Physiological physiology, Arm physiology, Movement physiology
- Abstract
Humans display accurate limb behavior when they move in familiar environments composed of many simultaneously-acting forces. Little is known about how multi-force environments are represented and whether this process partitions between the underlying force components, reflects the net forces present, or is cued to the force-context. We tested between these three main alternatives by examining how reaching movements adapt to a novel multi-force field composed of a velocity-dependent force and a constant force. These hypotheses were dissociated first by making the constant force larger and oppositely-oriented to the velocity-dependent force; thereby, the net force was always opposite the velocity-dependent component. Second, we tested adaptation with all novel forces removed to eliminate any potential cues for the force-context. In two experiments that used forces perpendicular or parallel to the forward movement direction, we found adaptation aftereffects consistent with a mechanism that partitioned the velocity-dependent component from the net force field. Specifically, we found aftereffects opposite the rightward or resistive velocity-dependent component of the multi-force field, even though the net force imposed was leftward or assistive, respectively. An additional experiment suggested that the velocity-dependent component is partitioned relative to the background load in a limb-based coordinate frame.
- Published
- 2005
- Full Text
- View/download PDF
34. Random change in cortical load representation suggests distinct control of posture and movement.
- Author
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Kurtzer I, Herter TM, and Scott SH
- Subjects
- Action Potentials physiology, Animals, Behavior, Animal, Electromyography methods, Functional Laterality, Macaca mulatta, Male, Models, Neurological, Motor Cortex physiology, Spectrum Analysis, Time Factors, Torque, Extremities physiology, Motor Cortex cytology, Movement physiology, Neurons physiology, Posture physiology, Psychomotor Performance physiology
- Abstract
Accurately maintaining a fixed limb posture and quickly moving between postures underlies both everyday skills, including holding and lifting a cup of coffee, and expert skills, such as an Olympic wrestler's holding and throwing an opponent. A fundamental question in limb motor control is whether the brain manages these contrasting goals of posture and movement through a single, robust control process or whether each engages a specialized control process. We addressed this question by examining how individual neurons in the primary motor cortex of macaque monkeys represent mechanical loads during posture and movement tasks. Notably, approximately half of the neurons that expressed load-related activity did so exclusively during either posture only or movement only. Further, those neurons with load-related activity during both tasks randomly switched their magnitude of response between tasks. These random changes in load representation suggest specialized control processes, one for posture and one for movement.
- Published
- 2005
- Full Text
- View/download PDF
35. Task-dependent motor learning.
- Author
-
Kurtzer I, DiZio P, and Lackner J
- Subjects
- Adaptation, Physiological physiology, Adult, Feedback physiology, Humans, Male, Psychomotor Performance physiology, Space Perception physiology, Learning physiology, Motor Activity physiology, Movement physiology
- Abstract
We examined whether task-dependent modulation was evident in a motor learning paradigm. Subjects performed reaching movements before, during, and after exposure to a novel force perturbation while adopting either a spatial goal, "continue towards the target", or an effort goal, "keep your effort profile the same". Before the perturbation, the hand trajectories were moderately straight and accurate regardless of the task. However, during and immediately after the perturbation, the reaches exhibited unambiguous task-dependent differences in both the initial and terminal periods of the reach. With the spatial goal, subjects showed terminal compensations to the force-induced displacements indicative of feedback control. In addition, feedforward control was evident in the smaller path deviations with continued exposure and the initial path aftereffects when the perturbation was removed. In contrast, when adopting an effort goal, subjects showed large and chronically deviated endpoints from the perturbation indicating an absence of feedback compensation. They also showed no feedforward adaptation during repeated exposure or visible aftereffects when the perturbation was removed. Therefore, both feedforward and feedback control mechanisms show task-dependent modulation in a motor learning paradigm.
- Published
- 2003
- Full Text
- View/download PDF
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