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Since the first description of chondroectodermal dysplasia by Ellis and van Creveld in 1940,1 approximately 32 cases of this syndrome have been reported in the literature. Recent articles2-5 have reviewed the literature and discussed the salient features of the disease. Characteristically, there is ectodermal dysplasia, chondrodysplasia, and polydactyly, with or without associated congenital heart lesions and other defects.This report is concerned with the 33d case to be described and the results of chromosome analysis done on this patient. To our knowledge there have been no previous reports of chromosome studies in a patient with this syndrome. REPORT OF CASE A 3½-year-old white female of Italian descent, was admitted to the Jersey City Medical Center, N.J., on March 8, 1961 because of fever and respiratory distress of 24 hours' duration.Past History.—This patient was the product of a normal full-term pregnancy and delivery; birth weight was 2,778

A two-year-old Negro-South American girl presented with juvenile laryngeal papilloma which necessitated an emergency tracheostomy. During the next 1½ years of hospitalization, she required general anesthesia for surgical excision of recurrent growths on an average of once every 3.7 weeks. Inasmuch as the process continued unabated, autogenous vaccine prepared from her tumor was administered by 15 weekly injections. There was an apparent dramatic beneficial response with vocalization around the tracheostomy tube occurring for the first time within two months of the start of vaccine therapy. Tumor growth regressed completely, the tracheostomy tube was removed within six months of the utilization of vaccine treatment and the patient was discharged after two years of hospitalization.

DENOUEMENT AND DISCUSSION SHORT-RIB POLYDACTYLY DWARFISM: SALDINO-NOONAN TYPE MANIFESTATIONS The consistent anomalies present in the Saldino-Noonan type of short rib polydactyly dwarfism are hydropic appearance at birth, micromelia, polydactyly, and a narrow thorax. Growth retardation, small weight for gestational age, and decrease in heel-crown length are often present. The characteristic skeletal deformities include short, horizontally-oriented ribs, short tubular bones with metaphyseal dysplasia, small iliac bones, horizontal acetabulae, and premature ossification of epiphyses.Pulmonary hypoplasia is the most common visceral anomaly and next in frequency are anomalies associated with the gastrointestinal tract, which include persistent cloaca, imperforate anus, atresia and/or malrotation of the bowel, and short bowel. Cardiovascular anomalies include transposition, coarctation of the aorta, ventricular septal defects, double-outlet left ventricle, and hypoplastic aortic arch. Renal and genital anomalies are seen less frequently.Based on skeletal criteria, short-rib polydactyly dwarfism has been classified into two distinct types: the Majewski type and

During a cytogenetic investigation of adult narcotic addicts and their newborn offspring, a female infant with a 45,X karyotype was born to a woman who used heroin and cocaine. The baby had multiple features consistent with the Turner's syndrome phenotype, with the additional findings of bilaterally absent fifth toes. This infant was one of 30 offspring of drug addicts, and while this case might represent a fortuitous circumstance, the possibility of increased incidence of newborn chromosomal aberration with parental drug addiction must be considered.

THE DANGERS of femoral venipuncture have been poorly appreciated. Admittedly, there are few documented instances of complications among the countless venipunctures performed on pediatric patients. In a review of the recent literature only two cases of gangrene of the lower extremities1 and one case of arteriovenous fistula following venipuncture2 were found. However it is not rare for transient cyanosis of the lower extremities to occur after femoral venipuncture. The transient changes are attributed to vascular spasm, but persistence of this spasm may be an important factor in causing the irreversible changes that lead to gangrene. This process of irreversible change may be averted by prompt arteriotomy with exploration of the artery when the abnormal appearance of the extremity persists and fails to respond to local measures. REPORT OF A CASE A 2-week-old white male infant was brought to the Margaret Hague Maternity Hospital on July 31, 1964 for