1. Collagen-Based Nanoparticles as Drug Delivery System in Wound Healing Applications
- Author
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Kusnadi K, Herdiana Y, Rochima E, Putra ON, Mohd Gazzali A, and Muchtaridi M
- Subjects
wound healing ,biodegradability ,nanoparticles ,fabrication techniques ,collagen ,Medicine (General) ,R5-920 - Abstract
Kusnadi Kusnadi,1,2 Yedi Herdiana,1 Emma Rochima,3 Okta Nama Putra,1,4 Amirah Mohd Gazzali,5 Muchtaridi Muchtaridi1,6 1Department of Pharmacy Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia; 2Department of Pharmacy, Politeknik Harapan Bersama, Tegal, Central Java, 52147, Indonesia; 3Department of Fishery, Faculty of Fisheries and Marine Sciences, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia; 4Research Center for Agroindustry, National Research and Innovation Agency (BRIN), Cibinong, Jawa Barat, 16911, Indonesia; 5School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Penang, 11800, Malaysia; 6Research Collaboration Centre for Radiopharmaceuticals Theranostic, National Research and Innovation Agency (BRIN), Sumedang, West Java, 45363, IndonesiaCorrespondence: Muchtaridi Muchtaridi, Email muchtaridi@unpad.ac.idBackground: Conventional wound dressings often adhere to wounds and can cause secondary injury due to their lack of anti-inflammatory and antibacterial properties. In contrast, collagen-based nanoparticles (NPs) as drug delivery systems exhibit both biocompatibility and biodegradability, presenting a promising avenue for accelerating wound healing processes.Aims of Study: This review aims to provide a comprehensive overview of the mechanisms involved in wound healing, description of the attributes of ideal wound dressings, understanding of wound healing efficacy of collagen, exploring NPs-mediated drug delivery mechanisms in wound therapy, detailing the synthesis and fabrication techniques of collagen-based NPs, and delineating the applications of various collagen-based NPs infused wound dressings on wound healing.Methodology: This review synthesizes relevant literature from reputable databases such as Scopus, Science Direct, Google Scholar, and PubMed.Results: A diverse array of collagen-based NPs, including nanopolymers, metal NPs, nanoemulsions, nanoliposomes, and nanofibers, demonstrate pronounced efficacy in promoting wound closure and tissue regeneration. The incorporation of collagen-based NPs has not only become an agent for the delivery of therapeutics but also actively contributes to the wound healing cascade.Conclusion: In conclusion, In brief, the use of collagen-based NPs presents a compelling strategy for expediting wound healing processes.Keywords: wound healing, biodegradability, nanoparticles, fabrication techniques, collagen
- Published
- 2024