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1. What is the impact of one’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study

Author

An, Hoyoung, Yang, Hee Won, Oh, Dae Jong, Lim, Eunji, Shin, Jin, Moon, Dong Gyu, Suh, Seung Wan, Byun, Seonjeong, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Bae, Jong Bin, Han, Ji Won, and Kim, Ki Woong

Published
2023
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3. Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study

Author

Bae, Jong Bin, Lipnicki, Darren M, Han, Ji Won, Sachdev, Perminder S, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Llibre-Rodriguez, Juan J, Llibre-Guerra, Jorge J, Valhuerdi-Cepero, Adolfo J, Ritchie, Karen, Ancelin, Marie-Laure, Carriere, Isabelle, Skoog, Ingmar, Najar, Jenna, Sterner, Therese Rydberg, Scarmeas, Nikolaos, Yannakoulia, Mary, Dardiotis, Efthimios, Meguro, Kenichi, Kasai, Mari, Nakamura, Kei, Riedel-Heller, Steffi, Roehr, Susanne, Pabst, Alexander, van Boxtel, Martin, Köhler, Sebastian, Ding, Ding, Zhao, Qianhua, Liang, Xiaoniu, Scazufca, Marcia, Lobo, Antonio, De-la-Cámara, Concepción, Lobo, Elena, and Kim, Ki Woong

Subjects
Alzheimer's Disease, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Research, Neurodegenerative, Prevention, Neurosciences, Dementia, Aging, Acquired Cognitive Impairment, Neurological, Cohort Studies, Female, Humans, Middle Aged, Parity, Risk Factors, Alzheimer's disease, Risk factors, Women, for Cohort Studies of Memory in an International Consortium, Alzheimer’s disease, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundDementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied.MethodsWe harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype.ResultsAcross all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10-1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR = 2.99, 95% CI = 1.38-6.47) and Latin America (OR = 1.49, 95% CI = 1.04-2.12), while nulliparous women showed a higher dementia risk in Asia (OR = 2.15, 95% CI = 1.33-3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR = 6.86, 95% CI = 1.81-26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR = 1.91, 95% CI 1.07-3.39) and non-Alzheimer non-vascular dementia (OR = 3.47, 95% CI = 1.44-8.35) in Asia.ConclusionParity is associated with women's risk of dementia, though this is not uniform across regions and dementia subtypes.

Published
2020

6. A Preliminary Study on the Potential Protective Role of the Antioxidative Stress Markers of Cognitive Impairment: Glutathione and Glutathione Reductase

Author

Park, Sang-a, primary, Byeon, Gihwan, additional, Jhoo, Jin Hyeong, additional, Kim, Hyung-Chun, additional, Lim, Myoung-Nam, additional, Jang, Jae-Won, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Dong Young, additional, and Kim, Ki Woong, additional

Published
2023
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7. Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea

Author

Han, Ji Won, primary, Yang, Hee Won, additional, Bae, Jong Bin, additional, Oh, Dae Jong, additional, Moon, Dong Gyu, additional, Lim, Eunji, additional, Shin, Jin, additional, Kim, Bong Jo, additional, Lee, Dong Woo, additional, Kim, Jeong Lan, additional, Jhoo, Jin Hyeong, additional, Park, Joon Hyuk, additional, Lee, Jung Jae, additional, Kwak, Kyung Phil, additional, Lee, Seok Bum, additional, Moon, Seok Woo, additional, Ryu, Seung-Ho, additional, Kim, Shin Gyeom, additional, and Kim, Ki Woong, additional

Published
2023
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8. Driving Risk Questionnaire--Korean Version

Author

Byeon, Gihwan, primary, Kwon, Sung Ok, additional, Jhoo, Jin Hyeong, additional, Jang, Jae‐Won, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung‐Ho, additional, Youn, Jong Chul, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Dong Young, additional, and Kim, Ki Woong, additional

Published
2023
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9. Evidence of risky driving in Korean older adults: A longitudinal cohort

Author

Byeon, Gihwan, primary, Kwon, Sung Ok, additional, Jhoo, Jin Hyeong, additional, Jang, Jae‐Won, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung‐Ho, additional, Youn, Jong Chul, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Dong Young, additional, and Kim, Ki Woong, additional

Published
2022
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10. Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study.

Author

Oh, Dae Jong, Bae, Jong Bin, Lipnicki, Darren M., Han, Ji Won, Sachdev, Perminder S., Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung‐Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, and Skoog, Ingmar

Subjects
DISEASE risk factors, ALZHEIMER'S disease, CROSS-sectional method, NEUROPSYCHOLOGICAL tests, OLDER people
Abstract

Background: Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring. Methods: For this cross‐sectional study, we harmonized and pooled data for 17,194 older adults from nine population‐based cohorts of eight countries. These studies conducted face‐to‐face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring. Results: The mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15–1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31–2.26), but not with the risk of non‐AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15–1.97) and AD (OR = 1.80, 95% CI = 1.33–2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28–3.55 in males; OR = 1.68, 95% CI = 1.16–2.44 for females). Conclusions: Maternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Association of Low Emotional and Tangible Support With Risk of Dementia Among Adults 60 Years and Older in South Korea

Author

Oh, Dae Jong, primary, Yang, Hee Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2022
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14. Differential effects of completed and incomplete pregnancies on the risk of Alzheimer disease

Author

Jang, Hyesue, Bae, Jong Bin, Dardiotis, Efthimios, Scarmeas, Nikolaos, Sachdev, Perminder S., Lipnicki, Darren M., Han, Ji Won, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Yannakoulia, Mary, Kosmidis, Mary H., Hadjigeorgiou, Giorgos M., Sakka, Paraskevi, and Kim, Ki Woong

Published
2018
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15. The impact of the COVID-19 pandemic on depression in community-dwelling older adults: a prospective cohort study.

Author

Oh, Dae Jong, Yang, Hee Won, Suh, Seung Wan, Byun, Seonjeong, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Bae, Jong Bin, Han, Ji Won, and Kim, Ki Woong

Subjects
MENTAL depression risk factors, SOCIAL participation, CONFIDENCE intervals, SPIRITUALITY, PSYCHOLOGICAL vulnerability, MULTIPLE regression analysis, AGE distribution, ECONOMIC status, INTERVIEWING, GERIATRIC Depression Scale, DISEASE incidence, RISK assessment, PSYCHOLOGICAL tests, SEVERITY of illness index, SEX distribution, INDEPENDENT living, DESCRIPTIVE statistics, MENTAL depression, RESEARCH funding, LOGISTIC regression analysis, ODDS ratio, DATA analysis software, SMOKING, COVID-19 pandemic, LONGITUDINAL method, COMORBIDITY
Abstract

Background: There are growing concerns about the impact of the COVID-19 pandemic on the mental health of older adults. We examined the effect of the pandemic on the risk of depression in older adults. Methods: We analyzed data from the prospective cohort study of Korean older adults, which has been followed every 2 years. Among the 2308 participants who completed both the third and the fourth follow-up assessments, 58.4% completed their fourth follow-up before the outbreak of COVID-19 and the rest completed it during the pandemic. We conducted face-to-face diagnostic interviews using Mini International Neuropsychiatric Interview and used Geriatric Depression Scale. We performed generalized estimating equations and logistic regression analyses. Results: The COVID-19 pandemic was associated with increased depressive symptoms in older adults [ b (standard error) = 0.42 (0.20), p = 0.040] and a doubling of the risk for incident depressive disorder even in euthymic older adults without a history of depression (odds ratio = 2.44, 95% confidence interval 1.18–5.02, p = 0.016). Less social activities, which was associated with the risk of depressive disorder before the pandemic, was not associated with the risk of depressive disorder during the pandemic. However, less family gatherings, which was not associated with the risk of depressive disorder before the pandemic, was associated with the doubled risk of depressive disorder during the pandemic. Conclusions: The COVID-19 pandemic significantly influences the risk of late-life depression in the community. Older adults with a lack of family gatherings may be particularly vulnerable. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Effects of lifetime cumulative ginseng intake on cognitive function in late life

Author

Lho, Silvia Kyungjin, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Kayoung, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Kim, Tae Hyun, Moon, Seok Woo, Park, Jae Young, Park, Joon Hyuk, Byun, Seonjeong, Suh, Seung Wan, Seo, Ji Young, So, Yoonseop, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Kyoung Hwan, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Lee, Ju Ri, Jeong, Hyeon, Jeong, Hyun-Ghang, Jhoo, Jin Hyeong, Han, Kyuhee, Hong, Jong Woo, Han, Ji Won, and Kim, Ki Woong

Published
2018
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17. Driving-Related Adverse Events in the Elderly Men: A Population-Based Prospective Cohort Study

Author

Kim, Jae Sung, Bae, Jong Bin, Han, Kyuhee, Hong, Jong Woo, Han, Ji Hyun, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Kayoung, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Kim, Tae Hyun, Moon, Seok Woo, Park, Jae Young, Park, Joon Hyuk, Byun, Seonjeong, Suh, Seung Wan, Seo, Ji Young, So, Yoonseop, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Kyoung Hwan, Lee, Dong Young, Lee, Dong-Woo, Lee, Seok Bum, Lee, Jung Jae, Lee, Ju Ri, Jeong, Hyeon, Jeong, Hyun-Ghang, Jhoo, Jin Hyeong, Han, Ji Won, and Kim, Ki Woong

Subjects
Longitudinal study, Violation, business.industry, Incidence, Incidence (epidemiology), Cognition, Population based, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Accident, Memory, medicine, Dementia, Original Article, 030212 general & internal medicine, Adverse effect, Prospective cohort study, Memory test, business, 030217 neurology & neurosurgery, Biological Psychiatry, Driving, Demography
Abstract

Objective This study estimated the incidence of driving-related adverse events and examined the association of cognitive function with the risk of future driving-related adverse events in the elderly Korean male population.Methods We analyzed 1,172 male drivers aged 60 years or older in the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD). Using the data from Korean National Police Agency, we classified the participants into three groups: safe driving (drove for 2 years after baseline without a traffic accident or repeated violations), driving cessation (stopped driving), and risky driving (one or more traffic accidents or repeated violations). We estimated the incidences of driving cessation and risky driving, and examined the effect of cognitive function on their risks.Results The incidence of driving cessation and risky driving in the Korean male drivers aged 60 years or older was 19.3 and 69.9 per 1,000 person-years respectively and increased in the late 80s. Drivers with better baseline Word List Memory Test scores showed less risky driving (OR=0.94, p=0.039).Conclusion Driving-related adverse events increased in late 80s, and better memory function was protective against these events.

Published
2020

18. Exploration of Cognitive Outcomes and Risk Factors for Cognitive Decline Shared by Couples

Author

Yang, Hee Won, primary, Bae, Jong Bin, additional, Oh, Dae Jong, additional, Moon, Dong Gyu, additional, Lim, Eunji, additional, Shin, Jin, additional, Kim, Bong Jo, additional, Lee, Dong Woo, additional, Kim, Jeong Lan, additional, Jhoo, Jin Hyeong, additional, Park, Joon Hyuk, additional, Lee, Jung Jae, additional, Kwak, Kyung Phil, additional, Lee, Seok Bum, additional, Moon, Seok Woo, additional, Ryu, Seung-Ho, additional, Kim, Shin Gyeom, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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19. The impact of the COVID-19 pandemic on depression in community-dwelling older adults: a prospective cohort study

Author

Oh, Dae Jong, primary, Yang, Hee Won, additional, Suh, Seung Wan, additional, Byun, Seonjeong, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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21. Association Between Plasma Monocyte Trafficking-Related Molecules and Future Risk of Depression in Older Adults.

Author

Oh, Dae Jong, Bae, Jong Bin, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Han, Ji Won, and Kim, Ki Woong

Subjects
CD54 antigen, OLDER people, MONOCYTE chemotactic factor, CELL adhesion molecules, MENTAL depression, RESEARCH funding, ANTIGENS, MONOCYTES, LONGITUDINAL method
Abstract

Background: The recruitment of monocytes to the brain plays an important role in the development of depression. However, the association between plasma biomarkers of monocyte trafficking and depression is unclear. This study is aimed to examine the effects of plasma monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) on the risk of depression.Methods: Data were acquired from an ongoing prospective cohort study involving randomly sampled, community-dwelling Korean older adults, which has been followed every 2 years. We included 1539 euthymic older adults (age = 68.2 [5.6] years; 51.7% were women) without a history of major psychiatric disorders and dementia and neurological diseases. Geriatric psychiatrists diagnosed incident depression through a structured interview using the Korean version of the Mini-International Neuropsychiatric Interview.Results: Depression had developed in 134 (8.7%) participants during the follow-up period of 5.7 (0.8) years. The high-plasma MCP-1 tertile group showed twofold higher risk of depression than the low-plasma MCP-1 tertile group (hazards ratio = 2.00, 95% confidence interval = 1.27-3.13, p = .003). The association between high levels of plasma MCP-1 and future risk of depression was significant in the middle-plasma ICAM-1 and VCAM-1 tertile groups; the high-plasma MCP-1 tertile group showed about fourfold higher risk of depression than the low-plasma MCP-1 tertile group.Conclusions: Molecules involved in monocyte trafficking may be good candidates as diagnostic biomarkers and/or therapeutic targets for late-life depression. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Mood disorders increase mortality mainly through dementia: A community-based prospective cohort study

Author

An, Hoyoung, primary, Yang, Hee Won, additional, Oh, Dae Jong, additional, Lim, Eunji, additional, Shin, Jin, additional, Moon, Dong Gyu, additional, Suh, Seung Wan, additional, Byun, Seonjeong, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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23. Association Between Plasma Monocyte Trafficking-Related Molecules and Future Risk of Depression in Older Adults

Author

Oh, Dae Jong, primary, Bae, Jong Bin, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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24. Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study

Author

Bae, Jong Bin, primary, Han, Ji Won, additional, Song, Junghan, additional, Lee, Kyunghoon, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2021
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27. Mood disorders increase mortality mainly through dementia: A community-based prospective cohort study.

Author

An, Hoyoung, Yang, Hee Won, Oh, Dae Jong, Lim, Eunji, Shin, Jin, Moon, Dong Gyu, Suh, Seung Wan, Byun, Seonjeong, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, and Jhoo, Jin Hyeong

Subjects
DEMENTIA risk factors, STRUCTURAL equation modeling, ANALYSIS of variance, INTERVIEWING, RISK assessment, DEMENTIA, MENTAL depression, SURVIVAL analysis (Biometry), RESEARCH funding, LONGITUDINAL method, PROPORTIONAL hazards models, COMORBIDITY
Abstract

Objective: The effects of mood disorders on mortality may be mediated by their effects on the risk of dementia, and interventions to reduce the occurrence of dementia may reduce their overall mortality. This study aimed to investigate the direct effects of depressive and bipolar disorders on the 6-year risk of mortality and also their indirect effects on mortality due to their effect on the risk of dementia. Methods: A total of 5101 Koreans were selected from a community-based prospective cohort study, and 6-year risks of mortality and dementia in participants with depressive and bipolar disorders were estimated by Cox proportional hazard analysis. The direct and indirect effects of depressive and bipolar disorders on the risk of mortality were estimated using structural equation modeling. Results: The depressive and bipolar disorder groups showed 51% and 85% higher 6-year mortality, and 82% and 127% higher risk of dementia, respectively, compared to euthymic controls. The effects of depressive and bipolar disorders on mortality were mainly mediated by their effects on the risk of dementia in a structural equation model. The direct effects of each mood disorder on mortality were not significant. Conclusion: Both depressive and bipolar disorders increased the risks of mortality and dementia, and the effects of mood disorders on mortality were mainly mediated through dementia. As dementia occurs later in life than mood disorders, measures to prevent it may effectively reduce mortality in individuals with a history of mood disorders, as well as being more feasible than attempting to control other causes of death. [ABSTRACT FROM AUTHOR]

Published
2022
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29. A 9-Year Comparison of Dementia Prevalence in Korea: Results of NaSDEK 2008 and 2017

Author

Suh, Seung Wan, primary, Kim, You Joung, additional, Kwak, Kyung Phil, additional, Kim, Kiwon, additional, Kim, Moon-Doo, additional, Kim, Byung-Soo, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Moon, Seok Woo, additional, Park, Kyung Won, additional, Park, Jong-Il, additional, Park, Joon Hyuk, additional, Bae, Jae Nam, additional, Seo, Jiyeong, additional, Seong, Su Jeong, additional, Son, Sang Joon, additional, Shin, Il-Seon, additional, Ryu, Seung-Ho, additional, Lee, Kang Joon, additional, Lee, Nam-Jin, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Chang Uk, additional, Chang, Sung Man, additional, Jeong, Hyun-Ghang, additional, Cho, Maeng Je, additional, Cho, Seong-Jin, additional, Jhoo, Jin Hyeong, additional, Choe, Young Min, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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30. Analysis of Correlation Between Cognitive Function and Depressive Symptoms of the Elderly in Community

Author

Cho, Hyeon, primary, Byun, Gi Hwan, additional, Kwon, Sung Ok, additional, Han, Ji Won, additional, Bae, Jong bin, additional, Yang, Hee won, additional, Lim, Eunji, additional, Kim, Ki Woong, additional, Kwak, Kyung Phil, additional, Kim, Bong-Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jeong, Hyun-Ghang, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, and Jhoo, Jin Hyeong, additional

Published
2021
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31. Dual Sensory Impairment and Cognitive Impairment in the Korean Longitudinal Elderly Cohort

Author

Byeon, Gihwan, primary, Oh, Gyu Han, additional, Jhoo, Jin Hyeong, additional, Jang, Jae-Won, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Dong Young, additional, and Kim, Ki Woong, additional

Published
2021
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32. Executive dysfunction and risk of suicide in older adults: a population-based prospective cohort study

Author

Oh, Dae Jong, primary, Han, Ji Won, additional, Bae, Jong Bin, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2021
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33. Mediating Effects of the Risk Factors Shared within Couples on the Risks of Shared Cognitive Disorders

Author

Yang, Hee Won, primary, Bae, Jong Bin, additional, Oh, Dae Jong, additional, Moon, Dong Gyu, additional, Lim, Eunji, additional, Shin, Jin, additional, Kim, Bong Jo, additional, Lee, Dong Woo, additional, Kim, Jeong Lan, additional, Jhoo, Jin Hyeong, additional, Park, Joon Hyuk, additional, Lee, Jung Jae, additional, Kwak, Kyung Phil, additional, Lee, Seok Bum, additional, Moon, Seok Woo, additional, Ryu, Seung-Ho, additional, Kim, Shin Gyeom, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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34. Supplementary_Tables – Supplemental material for Chronic subsyndromal depression and risk of dementia in older adults

Author

Oh, Dae Jong, Han, Ji Won, Bae, Jong Bin, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, and Kim, Ki Woong

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, Supplementary_Tables for Chronic subsyndromal depression and risk of dementia in older adults by Dae Jong Oh, Ji Won Han, Jong Bin Bae, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo and Ki Woong Kim in Australian & New Zealand Journal of Psychiatry

Published
2020
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35. Chronic subsyndromal depression and risk of dementia in older adults

Author

Oh, Dae Jong, primary, Han, Ji Won, additional, Bae, Jong Bin, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2020
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36. Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study

Author

Suh, Seung Wan, primary, Han, Ji Won, additional, Han, Ji Hyun, additional, Bae, Jong Bin, additional, Moon, Woori, additional, Kim, Hye Sung, additional, Oh, Dae Jong, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Seo, Jiyeong, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2020
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37. Frequency of Depressive Disorders According to Cognitive Continuum in the Elderly Living in the Community

Author

Jo, Kyung Hwa, primary, Kwon, Song Ok, additional, Han, Ji Won, additional, Kim, Ki Woong, additional, Kwak, Kyung Phil, additional, Kim, Bong-jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jeong, Hyun-Ghang, additional, Kim, Tae Hui, additional, Park, Jae Young, additional, Jeong, Hyeon, additional, Ryu, Seung-Ho, additional, and Jhoo, Jin Hyeong, additional

Published
2020
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38. Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia

Author

Lee, Dongyun, primary, Kim, Bong-Jo, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Kayoung, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hyun, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Seo, Ji Young, additional, So, Yoonseop, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Kyoung Hwan, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Ju Ri, additional, Jeong, Hyeon, additional, Jeong, Hyun-Ghang, additional, Jhoo, Jin Hyeong, additional, Han, Kyuhee, additional, Hong, Jong Woo, additional, Bae, Jong Bin, additional, and Kim, Ki Woong, additional

Published
2020
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40. Epidemiological characteristics of subsyndromal depression in late life

Author

Oh, Dae Jong, primary, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2019
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41. Supplementary_table – Supplemental material for Epidemiological characteristics of subsyndromal depression in late life

Author

Oh, Dae Jong, Han, Ji Won, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, and Kim, Ki Woong

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, Supplementary_table for Epidemiological characteristics of subsyndromal depression in late life by Dae Jong Oh, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo and Ki Woong Kim in Australian & New Zealand Journal of Psychiatry

Published
2019
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42. Chronic subsyndromal depression and risk of dementia in older adults.

Author

Oh, Dae Jong, Han, Ji Won, Bae, Jong Bin, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, and Kim, Ki Woong

Subjects
DEMENTIA risk factors, CONFIDENCE intervals, MILD cognitive impairment, RISK assessment, MENTAL depression, STATISTICAL sampling, LONGITUDINAL method, PROPORTIONAL hazards models, OLD age
Abstract

Objectives: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its effect on the risk of dementia has barely been investigated. This study is aimed to investigate the effect of subsyndromal depression on dementia risk in cognitively normal older adults and patients with mild cognitive impairment. Methods: Data were collected from a nationwide, population-based, prospective cohort study on a randomly sampled Korean elderly population aged 60 years or older, which has been followed every 2 years. Using 6-year follow-up data of 4456 non-demented elderly, the authors examined the risk of dementia associated with late-onset subsyndromal depression using multivariate Cox proportional hazard models. After standardized diagnostic interviews, subsyndromal depression and dementia were diagnosed by the operational diagnostic criteria and Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria, respectively. Results: Subsyndromal depression tripled the risk of dementia in non-demented elderly individuals (hazard ratio = 3.02, 95% confidence interval = [1.56, 5.85], p < 0.001). In subgroup analyses, subsyndromal depression was associated with the risk of dementia in cognitively normal participants only (hazard ratio = 4.59, 95% confidence interval = [1.20, 17.54], p = 0.026); chronic/recurrent subsyndromal depression with increasing severity during the follow-up period was associated with the risk of dementia (hazard ratio = 15.34, 95% confidence interval = [4.19, 56.18], p < 0.001). Conclusion: Late-onset subsyndromal depression is a potential predictor of incident dementia when it is chronic or recurrent with increasing severity in cognitively normal older adults. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Anhedonia and Dysphoria Are Differentially Associated with the Risk of Dementia in the Cognitively Normal Elderly Individuals: A Prospective Cohort Study

Author

Lee, Ju Ri, primary, Suh, Seung Wan, additional, Han, Ji Won, additional, Byun, Seonjeong, additional, Kwon, Soon Jai, additional, Lee, Kyoung Hwan, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Lee, Dong-Woo, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2019
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44. Short Average Duration of NREM/REM Cycle Is Related to Cognitive Decline in an Elderly Cohort: An Exploratory Investigation

Author

Suh, Seung Wan, primary, Han, Ji Won, additional, Lee, Ju Ri, additional, Byun, Seonjeong, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Seo, Jiyeong, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Yoon, In Young, additional, and Kim, Ki Woong, additional

Published
2019
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45. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment

Author

Jang, Soomin, primary, Han, Ji Won, additional, Shin, Jiyoon, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Kayoung, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hyun, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Seo, Jiyeong, additional, So, Yoonseop, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Kyoung Hwan, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Ju Ri, additional, Jeong, Hyeon, additional, Jeong, Hyun-Ghang, additional, Jhoo, Jin Hyeong, additional, Han, Kyuhee, additional, Hong, Jong Woo, additional, and Kim, Ki Woong, additional

Published
2019
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46. P3-293: THE DIAGNOSTIC CRITERIA OF NEUROCOGNITIVE DISORDERS IN DSM-5 MAY HAVE POTENTIAL TO LOSE AT-RISK CLINICAL POPULATIONS

Author

Bae, Jong Bin, primary, Han, Ji Won, additional, Kwak, Kyung Phil, additional, Kim, Bong-Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2019
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47. Is Dementia More Fatal Than Previously Estimated? A Population-based Prospective Cohort Study

Author

Bae, Jong Bin, primary, Han, Ji Won, primary, Kwak, Kyung Phil, primary, Kim, Bong Jo, primary, Kim, Shin Gyeom, primary, Kim, Jeong Lan, primary, Kim, Tae Hui, primary, Ryu, Seung-Ho, primary, Moon, Seok Woo, primary, Park, Joon Hyuk, primary, Youn, Jong Chul, primary, Lee, Dong Young, primary, Lee, Dong Woo, primary, Lee, Seok Bum, primary, Lee, Jung Jae, primary, Jhoo, Jin Hyeong, primary, and Kim, Ki Woong, primary

Published
2019
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48. Epidemiological characteristics of subsyndromal depression in late life.

Author

Oh, Dae Jong, Han, Ji Won, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, and Kim, Ki Woong

Subjects
DIAGNOSIS of mental depression, MENTAL depression risk factors, AGE distribution, CONFIDENCE intervals, MENTAL depression, EXERCISE, GERIATRIC psychiatry, INTERVIEWING, LONGITUDINAL method, CLASSIFICATION of mental disorders, SEX distribution, SLEEP, LOGISTIC regression analysis, SOCIAL support, SOCIOECONOMIC factors, INDEPENDENT living
Abstract

Objectives: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study is to compare the prevalence, incidence and risk factors of subsyndromal depression with those of syndromal depression including major and minor depressive disorders in community-dwelling elderly individuals. Methods: In a nationwide community-based study of randomly sampled Korean elderly population aged 60 years or older (N = 6640), depression was assessed with standardized diagnostic interviews. At baseline and at 2-year and 4-year follow-ups, the authors diagnosed subsyndromal depression by the operational criteria and syndromal depression by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) diagnostic criteria. Multivariate logistic regression analyses were conducted to identify the risk factors for incident depression. Results: The age- and gender-adjusted prevalence rate of subsyndromal depression was 9.24% (95% confidence interval = [8.54, 9.93]), which was 2.4-fold higher than that of syndromal depression. The incidence rate of subsyndromal depression was 21.70 per 1000 person-years (95% confidence interval = [19.29, 24.12]), which was fivefold higher than that of syndromal depression. The prevalence to incidence ratio of subsyndromal depression was about half that of syndromal depression. The risk for subsyndromal depression was associated with female gender, low socioeconomic status, poor social support and poor sleep quality, while that of syndromal depression was associated with old age and less exercise. Conclusion: Subsyndromal depression should be validated as a clinical diagnostic entity, at least in late life, since it has epidemiological characteristics different from those of syndromal depression. [ABSTRACT FROM AUTHOR]

Published
2020
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49. Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia

Author

Han, Ji Won, primary, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Kayoung, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hyun, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Seo, Ji Young, additional, So, Yoonseop, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Kyoung Hwan, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Ju Ri, additional, Jeong, Hyeon, additional, Jeong, Hyun-Ghang, additional, Jhoo, Jin Hyeong, additional, Han, Kyuhee, additional, Hong, Jong Woo, additional, and Kim, Ki Woong, additional

Published
2018
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50. Prevalence and Risk Factors of Abusive Behaviors in the Caregivers of People with Dementia in Korea

Author

Kim, Taehyun, primary, Jeong, Hyeon, additional, Han, Ji Won, additional, Kwak, Kyung Phil, additional, Kim, Bong-Jo, additional, Kim, Shin-Kyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Bae, Jae Nam, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Lee, Jungwon, additional, and Kim, Ki Woong, additional

Published
2018
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