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Your search keyword '"Kwan, Jennifer Yin Yee"' showing total 15 results
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15 results on '"Kwan, Jennifer Yin Yee"'

4. Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma.

Author

Abdalla, Moustafa, Tran-Thanh, Danh, Moreno, Juan, Iakovlev, Vladimir, Nair, Ranju, Kanwar, Nisha, Abdalla, Mohamed, Lee, Jennifer PY, Kwan, Jennifer Yin Yee, Cawthorn, Thomas R, Warren, Keisha, Arneson, Nona, Wang, Dong-Yu, Fox, Natalie S, Youngson, Bruce J, Miller, Naomi A, Easson, Alexandra M, McCready, David, Leong, Wey L, Boutros, Paul C, and Done, Susan J

Subjects
Epithelial Cells, Humans, Carcinoma, Ductal, Breast, Breast Neoplasms, RNA-Binding Proteins, Cell Cycle Proteins, RNA, Messenger, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Genomics, Mutation, Genome, Human, Female, Comparative Genomic Hybridization, Neoplasm Grading, Transcriptome, MCF-7 Cells, Carcinoma, Ductal, Breast, Genome, Human, RNA, Messenger
Abstract

Almost all genomic studies of breast cancer have focused on well-established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells. To address this we created a unique dataset of epithelial samples ductoscopically obtained from ducts leading to breast carcinomas and matched samples from ducts on the opposite side of the nipple. Here, we demonstrate that perturbations in mRNA abundance, with increasing proximity to tumour, cannot be explained by copy number aberrations. Rather, we find a possibility of field cancerization surrounding the primary tumour by constructing a classifier that evaluates where epithelial samples were obtained relative to a tumour (cross-validated micro-averaged AUC = 0.74). We implement a spectral co-clustering algorithm to define biclusters. Relating to over-represented bicluster pathways, we further validate two genes with tissue microarrays and in vitro experiments. We highlight evidence suggesting that bicluster perturbation occurs early in tumour development.

Published
2017

7. Radiomic Biomarkers to Refine Risk Models for Distant Metastasis in HPV-related Oropharyngeal Carcinoma

Author

Kwan, Jennifer Yin Yee, Su, Jie, Huang, Shao Hui, Ghoraie, Laleh S., Xu, Wei, Chan, Biu, Yip, Kenneth W., Giuliani, Meredith, Bayley, Andrew, Kim, John, Hope, Andrew J., Ringash, Jolie, Cho, John, McNiven, Andrea, Hansen, Aaron, Goldstein, David, de Almeida, John R., Aerts, Hugo J., Waldron, John N., Haibe-Kains, Benjamin, O'Sullivan, Brian, Bratman, Scott V., and Liu, Fei-Fei

Published
2018
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12. 85: The Role of Cytokine Signaling in the Reversal of Chronic Lymphedema

Author

Kwan, Jennifer Yin Yee, primary, Xu, Wenxi, additional, Sandhu, Vandana, additional, Demidov, Valentin, additional, Shi, Willa, additional, Vitkin, Alex, additional, Jones, Jennifer, additional, Williams, Justin, additional, Haykal, Siba, additional, Haibe-Kains, Benjamin, additional, Brooks, David G., additional, Yip, Kenneth W., additional, and Liu, Fei-Fei, additional

Published
2020
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