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The present investigation aimed at evaluating the effect of Calliandra calothyrsus Meisn green manure on the quality improvement of maize (Zea mays L.) stover compost. To that end, two field experiments were installed with maize (Zea mays L.) and a successive potato (Solanum tuberosum L.) crop, which was specifically set up to investigate the potential residual effects of tested organo-mineral fertilizers. The potato (Solanum tuberosum L.) crop did not receive any fertilizer, either organic or mineral. The experimental design was a randomized complete block with three replicates. The basic experimental plot was 1.6 m wide and 3 m long (4.8 m²). Treatments under evaluation were: T1=Control, T2=Maize stover co-composted with mineral fertilizer, T3=Maize stover co-compost with Calliandra calothyrsus Meisn green manure; T4=Farm manure+45-60-30; and T5=Maize stover co-composted with Calliandra calothyrsus Meisn green manure+45-60-30. Evaluated parameters were grain yields, root biomass, above-ground biomass, Harvest Index, and Root/Shoot ratio for maize (Zea mays L.). Potato yields were categorized into small size (< 35 mm), medium size (35-65 mm) and big size tubers (> 65 mm). Significant effects (p < 0.001) of tested fertilizer treatments were observed for maize grain yields (GY), above-ground biomass (AGB), and root biomass (RB). No effect (p > 0.05) of fertilizer treatments could be noticed on the harvest index (HI=0.31-0.38) or R/S ratio (0.079-0.088). For the successive potato crop, a significant effect (p < 0.001) of tested treatments was only observed for the seed-oriented medium size tubers (MST) potato yield. Overall, the most relevant observation of the maize experiment is that treatments T4 and T5 gave higher and equivalent grain and biomass yields. From there, we derive that maize stover co-composted with Calliandra calothyrsus Meisn green manure could be a sound substitute to farm manure. Additionally, the potato experiment highlighted the residual effects of the T3 treatment, statistically equivalent to that of T2. Consequently, we advise that the effects of compost-based organo-mineral fertilizers on crop yields should be evaluated beyond a single seasonal crop, in order to fully catch their residual fertilizer potentials.&nbsp

Cowpea (Vigna unguiculata L.Walp) is a grain legume and a food major importance for millions of people, especially in less developed countries. It is not only rich in nutrients, but also in nutraceuticals such as dietary fibre, antioxidants and polyunsaturated fatty acids and polyphenols. An experiment was carried out in three blocks completely randomized at Rukoba hill of Kirimiro region to analyse the growth and yield parameters of four cowpea varieties ( Local, Katumani, Rurandaranda and Fahari) to assess the variety which is more adapted to the ecological conditions of the region. The studied parameters were: leaves number, leaf length and width, plant height, pods number per plant, leaf area, grains number per pod, plant height at pods formation and yield. The outcomes showed a significant increase in leaf length and width per plant for the Rurandarada variety than the local and other varieties. Moreover, this variety recorded significantly enhanced leaf area and an effectively improved plant height. Furthermore, rurandarada variety recorded a noteworthy increase in leaves number and has significantly improved yield compared to others. The study highlighted rurandarara variety as the most adapted variety. This suggested that rurandaranda could be considered as a variety that could be cultivated in the area for the promotion of food security and the health of the population.

In Burundi, the major problem for livestock is the lack of sufficient nutrients needed for its growth and development due to Burundi higher population growth rate which put a pressure on arable lands and pastures leading to grass pastures reduction. However the concentrates that can be used alternatively are not only insufficient, but also very expensive under the local farmer conditions. In the Burundi, livestock reduction was recorded while it occupies an important place in Burundian life, especially for smallholders to whom it plays a major role in terms of social life, health and income generation. Fortunately, stylosanthes Guianensis has been identified as an herbaceous forage legume with potential protein supplements of better impacts on livestock growth, development and production. It is more accessible to smallholder, whence this study has been carried out to improve stylosanthes production for better livestock feeding. The experiment has considered six seedling spacing as treatments to analyze the treatment which could effectively improve the stylosanthes production parameters in Imbo natural region. These treatments (T1 (40cm X 5 cm); T2 (40cm X 10 cm), T3 (50cm X 5 cm), T4 (50cm X 10 cm), T5 (60cm X 5 cm), T6 (60cm X 10 cm)) were ranged in three blocs completely randomized with three replications. Data were sampled at the 8th, 10th, 12th, 14th, 16th, 18th, and the 21st weeks after germination by recording as parameters: plant height, ramifications number, plant water content, green and dry matters. All data were analyzed through SPSS at P

The present investigation highlights and compares the direct and residual fertilizer values of maize (Zea mays L.) stover composted with Calliandra calothyrsus Meisn and Tithonia diversifolia (Hemsl.) A. Gray-green manure on maize (Zea mays L.) and successive potato (Solanum tuberosum L.). Two field studies were installed with maize and successive potato crops in a completely randomized block design (CRBD) with three replicates. Statistical analyses were performed using R commander, version 4.0.2. Grain yields, root biomass, above ground biomass and calculated parameters (Root/Shoot ratio, Harvest Index and GinningRate) were evaluated for maize. Total potato yields were evaluated and categorized into small size tubers (SST < 35 mm) medium size tubers (MST: 35-65 mm) and big size tubers (BST > 65 mm). Treatments under evaluation were: T1=Control, T2=Farm (cow) manure alone, T3=Maize stover co-composted with Calliandra calothyrsus Meisn green manure; T4= Maize stover co-composted with Tithonia diversifolia (Hemsl.) A. Gray green manure; T5= Farm (cow) manure+45-60-30; T6= Maize stover co-composted with Calliandra calothyrsus Meisn green manure+45-60-30; T7=Maize stover co-composted with Tithonia diversifolia (Hemsl.) A. Gray green manure+45-60-30; and T8=Farm (cow) manure+FOMI Imbura+FOMI Totahaza. Obtained results indicated highest maize yields with FOMI organo-mineral fertilizers (2.7 T/ha) seconded by the recommended fertilizer practice T5 (2 T/ha). In the same line, highest R/S value (=0.38) was registered with the same FOMI treatment (T8), while the highest HI value (0.21) was observed with the maize stover co-composted with Tithonia diversifolia (Hemsl.) A. Gray (T4). Highest potato total yields were observed with the maize stover compost enriched with Tithonia diversifolia (Hemsl.) A. Gray and supplemented with mineral fertilizer (7.61 T/ha), followed by the same compost without mineral fertilizer addition (6.35 T/ha). We conclude our study with the following statements: i) the highest direct fertilizer value was observed with the FOMI treatment; ii) the residual fertilizer effects were more expressed with the maize stover co-composted with Tithonia diversifolia A. Gray green manure with or without mineral additive, followed by farm manure and maize stover enriched with Calliandra calothyrsus Meisn green manure. Consequently, we restate that the effects of compost-based organo-mineral fertilizers on crop yields should be definitely evaluated on a multiseasonal basis so as to fully capture their residual fertilizer potentials.

Objectives: To find out the method which could effectively control erosion to improve the crop growth parameters at Buhoro hill. Methods/Statistical Analysis: The experiments have considered three plots with three different erosion control methods such as the traditional plowing methods (M1) which was the control, anti-erosive hedges planting (M2) and anti-erosive hedges coupled with anti-erosive ditches (M3). The experiments were carried out in 2016 and 2017. Data were recorded at three homogeneous regions (upstream, middle and downstream) by choosing two lines at each region and analyzed through SPSS at P

An 8-week incubation study was conducted under controlled laboratory conditions to evaluate the potential acidifying effect of urea and Di-Ammonium Phosphate (DAP) on three Burundi representative soils, namely two acidic high altitude soils (Nyabisindu and Kajondi) and a saline-sodic soil from the Imbo plain (Gihanga). Urea was applied at equivalent rates of 40 and 80 kg ha-1, while Di-Ammonium Phosphate (DAP) was applied at 100 and 200 kg ha-1. At the completion of the study, the acidifying effect of urea and DAP increased with the increasing original soil pH values. In comparison with the unfertilised control treatments, soil pH decreased by - 0.18 to - 0.217 pH units in Nyabisindu soil (pH = 5.07), whereas in Kajondi soil (pH = 5.2) and Gihanga (pH = 7.40), it decreased by - 0.073 to - 0.286 and - 0.367 to - 0.470 pH units, respectively. Furthermore, results highlighted that each soil-applied kg of N as urea and each soil-applied kg of N as DAP requires 3.6 kg and 5.4 kg of CaCO3 to neutralize their respective residual acidity. The study revealed a helpful approach of using CaCO3 as a rational N fertilizers management that the agriculture extension services and farmers can undertake in order to reduce soil acidity, improve soil fertility and increase crop production in Burundi and beyond under similar soil conditions.

An incubation study was conducted for 56 days under room temperature in a high altitude acidic soil (pH = 4.2) to evaluate carbon(C) mineralization from pea (Pisum sativum L.) residues and leaves from two agroforestry species (Calliandra calothyrsus Meisnand Gliricidia sepium (Jacq.) Walp. Carbon dioxide (CO2) evolution was measured at 7, 14, 21, 28, 42 and 56 days of incubation.Carbon mineralization was best fit to a sequential decomposition model with a rapid and slow phase, each described by first-order kinetics. Percent rapid, rapid and slow fraction rate constants and half-lives were determined. At the completion of the study, percent decomposition was higher for Pisum sativum L. (77.3 %) followed by Calliandra calothyrsus Meisn (60.8 %) andGliricidia sepium (Jacq.) Walp (56.7 %). Similarly, higher percent rapid fractions (78 %), higher decomposition rate constants (kr= 0.053 day-1 ; ks = 0.012 day-1 ) and lower half-lives [t0.5(r) = 13 days; t0.5(s) = 58 days] were also observed with Pisum sativum L.residues. From the findings of this investigation, it appears that the higher lignin content of the two agroforestry species, Gliricidiasepium (Jacq.) Walp (6.33 %) and Calliandra calothyrsus Meisn (4.16 %) was the limiting factor of their decomposability, as compared to Pisum sativum L. which had zero lignin content. This study highlighted pea (Pisum sativum L.) residue as the mosteffective in C mineralization.

Rice is a portion of luxury food, a cereal that constitutes a major source of calories for the urban and rural population. It is the second-largest crop grown worldwide. In Burundi country, rice demand has been increasing more rapidly in both urban and sub-urban areas due to its use in alcohol and oil fabrication, marketing for household economic income, and cattle feeding. Unfortunately, rice production is limited due to population growth, coupled with its cultivation almost in lower altitude regions only. An experiment on the characterization of new rice lines for the development of high-yielding genotypes with desirable agronomic traits was carried out to assess the most adapted lines which could be recommended to farmers in the region. The experiment was laid out in randomized complete block design with three replications. It has considered 10 rice lignes (V3, V7, V8, V13, V14, V16, V18, V22, V34, V35), planted on 8 ha area, divided into single plots of 8 m2 each with 20 X 20 cm for spacing. Based on statistic analysis, the results of the study showed line V34 as the most adapted variety with significant differences compared to other lines. It showed improved growth parameters as plant height, panicles exsertion and panicles length. Moreover, this line V34 has recorded enhanced yield with p

Seedling spacing is an important factor which plays a vital role in boosting yield. Many plants are very sensitive to this factor especially cowpea, a key plant with major benefits to households nutrition and health around the world. However, cowpea seedling spacing still a factor that requires adjustment in many countries, especially in Burundi where this crop is not yet well domesticated, with cultivation under traditional systems, inadequate planting methods coupled with lack of different varieties. An experiment was carried out in three blocks completely randomized with three replications for each. It has considered three cowpea varieties (local and Tanzanian varieties (Katumani and Vuli)) and four seedling spacing (SS): SS1 (50cmX40cm); SS2 (50cmX50cm); SS3 (60cmX40cm) and SS4 (60cmX50cm). Results highlighted Seedling spacing SS1 as the effective seedling spacing which could effectively improve all studied growth parameters and yield attributes for local and katumani varieties. It has effectively improved plant height; leaf area index; the number of flowers, pods and grains. Moreover, this seedling spacing has also recorded enhanced crop yield, whence it has been considered as the most effective seedling spacing, especially for local (L) and katumani (K), varieties which could be considered for cultivation in Burundi. Regarding Vuli variety, although it has also recorded improved yield, data variabilities was observed, whence further studies were recommended for more clarification.&nbsp

Lower soil fertility was identified as a major problem affecting crop yield in Burundi, especially at Bihunge, a hill of Matongo commune Kayanza province. An experiment was therefore carried out with five treatments to assess the effective and economically affordable treatment on maze growth parameters improvement. The experimental has considered five treatments: the control (T1); Compost from maize residues + mineral adjuvant (T2); Compost from maize residues + organic adjuvant based on Calliandra calothyrsus Meisn (T3); ISABU formula for maize fertilization (T4); the maize compost + Calliandra + recommended mineral fertilization for maize (T5)), in randomized complete blocks with three replications for each. The recorded parameters were the leaves number, plant height, stem girth as well as the leaf area. After analysis with SPSS and Advanced Excel, results showed a significant difference between treatments. The treatment T4 was the most effective in improving all growth parameters than others and showed a significant difference from treatments T1, T2, and T3. However, it did not differ to treatment T5 which also significantly differed from other treatments with P

Erosion negatively affects crop yields and decreases crop productivity. It removes nutrients, reduces rooting depth, and damages soil structure, resulting in negative nutrient balances and lower crop yields. A study for two years was conducted using three soil erosion control methods to appraise the method which could effectively control erosion and improve bean production characteristics on a hill more prone to erosion. Designed on three different plots ( P1, P2, P3) divided in four sub plots (S1, S2, S3, S4), these methods were traditional plowing method (M1); anti-erosive hedges planting method (M2) and anti-erosive hedges coupled with anti-erosive ditches (M3). The recorded parameters were the number of: pods, full pods and grains, as well as the average yield weight. After analysis with SPSS and Advanced excel, results showed no significant difference between M1 and M2 but highlighted the significant effects of M3 method in improving the number of: pods, full pods and grains. Likewise, this method has somehow enhanced the average yield weight. These outcomes suggest M3 as the most effective method in enhancing bean production characteristics and yield at Buhoro hill.

Soil water deficit is a principal and biotic factor that limits plant growth and development. Amaranth is very sensitive to water stress. Foregoing research highlighted a reduced amaranth leaf area and dry matter, while others affirmed that water deficit impaired amaranth growth and yield. Although amaranth is recorded as the most important annual crops with higher nutritional value worldwide, higher reduction of amaranth production has been recorded in Burundi, while published information is limited concerning affective irrigation rate for improving amaranth growth and yield in this country. An experiment was carried out in Bujumbura peri-urban zone to evaluate the effective irrigation rate for amaranth cultivation. It was laid out as completely randomized blocs design, consisting of three treatments with different irrigation rates as treatment T1 (10%), treatment T2 (30%) and treatment T3 (60%) with six repetitions for each. During the experiment, growth parameters (number of leaves, stem diameter, plant height, leaf area and root growth) and production attributes (fresh and dry weight of leaves and roots) were measured. The results highlighted treatment T2 of 30% irrigation rate as the most significant and effective treatment. It has significantly improved the number of leaves, stem diameter, plant height, leaf area and root growth. Moreover, this treatment T2 has effectively enhanced the water use efficiency, fresh and dry weight of leaves and roots. It can be used to improve the growth and production of amaranth in Bujumbura peri-urban zone.

Bean is globally an important leguminous vegetable that has been used for several centuries as a food for humans. Originated from the American, the bean is now cultivated all over the world due to its nutritional and culinary values. However, it is verysensitive to applied fertilizers. In Mabayi commune of Cibitoke province, many farmers use to cultivate bean without potassiumwhile it is one of the most important nutrients for plant growth and development. An experiment was carried out in completelyrandomized blocs design with three treatments (T1 (NPK: 00-00-00), T2 (NPK: 18-46-00) and T3 (NPK: 18-46-30)) and four replications for each to evaluate the treatments which could effectively improve crop bean growth and yield parameters. Therecorded parameters were the plant height, leaf area, flowers number, stem diameter, root length, yield and production attributes (number of pods, grains, full pods and empty pods). The results highlighted treatment T3 as the most effective treatment. It has significantly improved plant height, leaf area, flowers number, stem diameter, and root length. Moreover, treatment T3 has enhanced the yield and number of pods, grains and full pods. The treatment T3 is suggested for improving the bean growth and yield parameters at Nyabungere hill in Mabayi commune.

Bean belongs to legumes, which play a significant role in human nutrition. An experiment was carried out in a greenhouse to evaluate the irrigation level which could effectively improve bean crop growth and yield parameters. It was laid out as completely randomized blocs design and has considered three treatments of irrigation levels (treatment T1 (5%), T2 (35%) and T3 (65%)) with six replications for each. The recorded parameters were the leaves number, stem diameter, plant height, leaf area, and production attributes. The results highlighted treatment T2 as the most effective treatment. It has significantly improved the leaves number, stem diameter, plant height and leaf area. Moreover, treatment T2 has enhanced the fresh and dry weight of leaves, stem and roots. This treatment T2 can be used to improve the bean growth and yield parameters in Bujumbura peri - urban zone.

Introduction: P-glycoprotein transporters (P-gp) at the Blood-Brain barrier (BBB) are efflux pumps that play an important role in protecting the brain against harmful substances. The expression and function of these proteins is of great interest in neurodegenerative diseases and drug resistance. Its function can be measured in vivo with positron emission tomography (PET) using the novel tracer 5-(1-(2-[18F]fluoroethoxy))-[3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-propyl]-5,6,7,8-tetrahydronaphthalen, [18F]MC225. Preclinical PET scans are performed under anesthesia, and in most longitudinal studies the animals are repeatedly anesthetized. However, the potential effect of anesthesia on P-gp function has not been explored yet using this tracer. Therefore, the aim of this study is to assess the effect of a pre-exposure to anesthesia on P-gp function in rats with [18F]MC225. Material and Methods: Six rats were anesthetized with isoflurane for 90 minutes. Five other rats were not subjected to anesthesia. One week later, all rats underwent a dynamic PET scan (60 min) with arterial blood sampling. [18F]MC225 with a dose of 32±6 MBq and a molar activity higher than 29000 GBq/mmol was injected into a tail vein as a bolus of 1ml/min. After tracer injection, blood samples (0.15 ml) were collected to measure radioactivity in whole blood and plasma, besides the parent fraction of the tracer and its radioactive metabolites. The images were processed with PMOD software, and registered to a tracer-specific brain template. A total of 16 regions inside the brain were selected from a Wistar brain rat atlas. The volume of distribution (VT) which reflects P-gp function was calculated by Logan analysis using plasma activity corrected for metabolites as input function. Results: Significant differences in VT of the whole brain were observed (p=0.002) between the 2 groups. In control animals, VT of the whole brain was 11.04±1.25, whereas in animals pretreated with anesthesia it was 7.89±1.25, a decrease of 29%. Moreover, significant decreases in VT were found between groups in all the brain regions analyzed such as amygdala, hippocampus, hypothalamus, midbrain. Tracer concentration in whole-blood and plasma, and the rate of metabolism were not significantly different between the groups. Discussion/Conclusion: Our results suggest that anesthesia has a prolonged effect on P-gp function at the BBB, lasting at least one week. The group with additional anesthesia displayed a significant decrease of tracer uptake in brain indicating an up-regulation of P-gp. The results indicate that [18F]MC225 is suitable for the detection of increases of P-gp function after drug treatment.

OP03 Selective extraction of medically-related radionuclides from proton-irradiated thorium targets, V. Radchenko, J.W. Engle, C. Roy, J. Griswold, M.F. Nortier, E.R. Birnbaum, M. Brugh, S. Mirzadeh, K. D. John, M.E. Fassbender, OP04 Comparison of [68Ga]FSC(succ-RGD)3 and [68Ga]NODAGA-RGD for PET imaging of αvβ3 integrin expression, Chuangyan Zhai, Gerben M. Franssen, Milos Petrik, Peter Laverman, Clemens Decristoforo, OP05 A new NPY-Y1R targeting peptide for breast cancer PET imaging, Ait-Mohand Samia, Dumulon-Perreault Véronique, Guérin Brigitte, OP06 The influence of multivalency on CCK 2 receptor targeting, D. Summer, A. Kroess, C. Rangger, H. Haas, P. Laverman, F. Gerben, E. von Guggenberg, C.Decristoforo, OP07 SPECT Imaging of αvβ3 Expression by [99mTc(N)PNP43]- Bifunctional Chimeric RGD Peptide not Cross-Reacting with αvβ5, Cristina Bolzati, Nicola Salvarese, Fiorenzo Refosco, Laura Meléndez-Alafort, Debora Carpanese, Antonio Rosato, Michele Saviano, Annarita Del Gatto, Daniela Comegna, Laura Zaccaro, OP09 New dienophiles for the inverse-electron-demand Diels-Alder reaction and for pretargeted PET imaging, Emilie Billaud, Muneer Ahamed, Frederik Cleeren, Elnaz Shahbazali, Tim Noël, Volker Hessel, Alfons Verbruggen and Guy Bormans, OP10 New complexing agent for Al18F-labelling of heat-sensitive biomolecules: Synthesis and preclinical evaluation of Al18F-RESCA1-HAS, Cleeren F, Lecina J, Koole M, Verbruggen A and Bormans G, OP11 A novel versatile precursor efficient for F-18 radiolabelling via click-chemistry, B. Lugatoa, S. Stucchia, E.A. Turollaa, L. Giulianoa, S.Toddea, P. Ferraboschib, OP12 A general applicable method to quantify unidentified UV impurities in radiopharmaceuticals, R.P. Klok, M.P.J. Mooijer, N.H. Hendrikse, A.D. Windhorst, OP13 Development of [18F]Fluoro-C-glycosides to radiolabel peptides, Collet C., Petry N., Chrétien F., Karcher G., Pellegrini-Moïse N., Lamandé-Langle S., OP14 A Microfluidic Approach for the 68Ga-labeling of PSMAHBED-CC and NODAGA-RGD, Sarah Pfaff, Cecile Philippe, Markus Mitterhauser, Marcus Hacker, Wolfgang Wadsak, OP16 Surprising reactivity of astatine in the nucleophilic substitution of aryliodonium salts: application to the radiolabeling of antibodies, François Guérard, Yong-Sok Lee, Sébastien Gouard, Kwamena Baidoo, Cyrille Alliot, Michel Chérel, Martin W. Brechbiel, Jean-François Gestin, OP17 64Cu-NOTA-pertuzumab F(ab')2 fragments, a second-generation probe for PET imaging of the response of HER2-positive breast cancer to trastuzumab (Herceptin), Lam K, Chan C, Reilly RM, OP18 Development of radiohalogenated analogues of a avb6-specific peptide for high LET particle emitter targeted radionuclide therapy of cancer, Salomé Paillas, John Marshall, Jean-Pierre Pouget, Jane Sosabowski, OP19 Ligand Specific Efficiency (LSE) as a guide in tracer optimization, Emmanuelle Briard, Yves P. Auberson, John Reilly, Mark Healy, David Sykes, OP23 The radiosynthesis of an 18F-labeled triglyceride, developed to visualize and quantify brown adipose tissue activity, Andreas Paulus, Wouter van Marken Lichtenbelt,Felix Mottaghy, Matthias Bauwens, OP24 Influence of the fluorescent dye on the tumor targeting properties of dual-labeled HBED-CC based PSMA inhibitors, Baranski, Ann-Christin, Schäfer, Martin, Bauder-Wüst, Ulrike, Haberkorn, Uwe, Eder, Matthias, Kopka, Klaus, OP25 [18F]MEL050 as a melanin PET tracer : fully automated radiosynthesis and evaluation for the detection of pigmented melanoma in mice pulmonary metastases, Chaussard M, Hosten B, Vignal N, Tsoupko-Sitnikov V, Hernio N, Hontonnou F, Merlet P, Poyet JL, Sarda-Mantel L, Rizzo-Padoin N, OP26 Design and Preclinical Evaluation of Novel Radiofluorinated PSMA Targeting Ligands Based on PSMA-617, J. Cardinale, M. Schäfer, M. Benešová, U. Bauder-Wüst, O. Seibert, F. Giesel, U. Haberkorn, M. Eder, K. Kopka, OP27 A novel radiolabeled peptide for PET imaging of prostate cancer: 64Cu-DOTHA2-PEG-RM26, Mansour Nematallah, Paquette Michel, Ait-Mohand Samia, Dumulon-Perreault Véronique, Lecomte Roger, Guérin Brigitte, OP29 Biodistribution of [18F]Amylovis®, a new radiotracer PET imaging of β-amyloid plaques, Fernandez-Maza L, Rivera-Marrero S, Prats Capote A, Parrado-Gallego A, Fernandez-Gomez I, Balcerzyk M, Sablon-Carrazana M, Perera-Pintado A, Merceron-Martinez D, Acosta-Medina E, Rodriguez-Tanty C, OP30 Synthesis and preclinical evaluation of [11C]-BA1 PET tracer for the imaging of CSF-1R, Bala Attili, Muneer Ahamed, Guy Bormans, OP31 In vivo imaging of the MCHR1 in the ventricular system via [18F]FE@SNAP, C. Philippe, M. Zeilinger, T. Scherer, C. Fürnsinn, M. Dumanic, W. Wadsak, M. Hacker, M. Mitterhauser, OP32 Synthesis of the first carbon-11 labelled P2Y12 receptor antagonist for imaging the anti-inflammatory phenotype of activated microglia, B. Janssen, D.J. Vugts, G.T. Molenaar, U. Funke, P.S. Kruijer, F. Dollé, G. Bormans, A.A. Lammertsma, A.D. Windhorst, OP33 Radiosynthesis of a selective HDAC6 inhibitor [11C]KB631 and in vitro and ex vivo evaluation, Koen Vermeulen, Muneer Ahamed, Michael Schnekenburger, Mathy Froeyen, Dag Erlend Olberg, Marc Diederich, Guy Bormansa, OP34 Improving metabolic stability of fluorine-18 labelled verapamil analogues, Raaphorst RM, Luurtsema G, Lammertsma AA, Elsinga PH, Windhorst AD, OP36 Development of a novel PET tracer for the activin receptor-like kinase 5, Lonneke Rotteveel, Uta Funke, Peter ten Dijke, Harm Jan Bogaard, Adriaan A. Lammertsma, Albert D. Windhorst, OP37 SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo, Lei Song, Sarah Able, Nadia Falzone, Veerle Kersemans, Katherine Vallis, OP38 Melanoma targeting with [99mTc(N)(PNP3)]-labeled NAPamide derivatives: preliminary pharmacological studies, Davide Carta, Nicola Salvarese, Wiebke Sihver, Feng Gao, Hans Jürgen Pietzsch, Barbara Biondi, Paolo Ruzza, Fiorenzo Refosco, Cristina Bolzati, OP39 [68Ga]NODAGA-RGD: cGMP synthesis and data from a phase I clinical study, Roland Haubner, Armin Finkensted, Armin Stegmair, Christine Rangger, Clemens Decristoforo, Heinz Zoller, Irene J. Virgolin, OP44 Implementation of a GMP-grade radiopharmacy facility in Maastricht, Ivo Pooters, Maartje Lotz, Roel Wierts, Felix Mottaghy, Matthias Bauwens, OP45 Setting up a GMP production of a new radiopharmaceutical, Forsback, Sarita, Bergman Jörgen, Kivelä Riikka, OP48 In vitro and in vivo evaluation of 68-gallium labeled Fe3O4-DPD nanoparticles as potential PET/MRI imaging agents, M. Karageorgou, M. Radović, C. Tsoukalas, B. Antic, M. Gazouli, M. Paravatou-Petsotas, S. Xanthopouls, M. Calamiotou, D. Stamopoulos, S. Vranješ-Durić, P. Bouziotis, OP49 Fast PET imaging of inflammation using 68Ga-citrate with Fe-containing salts of hydroxy acids, A. S. Lunev, A. A. Larenkov, K.A. Petrosova, O. E. Klementyeva, G. E. Kodina, PP01 Installation and validation of 11C-methionine synthesis, Kvernenes, O.H., Adamsen, T.C.H., PP02 Fully automated synthesis of 68Ga-labelled peptides using the IBA Synthera® and Synthera® Extension modules, René Martin, Sebastian Weidlich, Anna-Maria Zerges, Cristiana Gameiro, Neva Lazarova, Marco Müllera, PP03 GMP compliant production of 15O-labeled water using IBA 18 MeV proton cyclotron, Gert Luurtsema, Michèl de Vries, Michel Ghyoot, Gina van der Woude, Rolf Zijlma, Rudi Dierckx, Hendrikus H. Boersma, Philip H. Elsinga, PP04 In vitro Nuclear Imaging Potential of New Subphthalocyanine and Zinc Phthalocyanine, Fatma Yurt Lambrecht, Ozge Er, Mine Ince, Cıgır Biray Avci, Cumhur Gunduz, Fatma Aslihan Sarı, PP05 Synthesis, Photodynamic Therapy Efficacy and Nuclear Imaging Potential of Zinc Phthalocyanines, Kasim Ocakoglu, Ozge Er, Onur Alp Ersoz, Fatma Yurt Lambrecht, Mine Ince, Cagla Kayabasi, Cumhur Gunduz, PP06 Radio-U(H)PLC – the Search on the Optimal Flow Cell for the γ-Detector, Torsten Kniess, Sebastian Meister, Steffen Fischer, Jörg Steinbach, PP07 Radiolabeling, characterization & biodistribution study of cysteine and its derivatives with Tc99m, Rabia Ashfaq, Saeed Iqbal, Atiq-ur-Rehman, Irfan ullah Khan, PP08 Radiolabelling of poly (lactic-co.glycolic acid) (PLGA) nanoparticles with 99mTC, R Iglesias-Jerez, Cayero-Otero, L. Martín-Banderas, A. Perera-Pintado, I. Borrego-Dorado, PP09 Development of [18F]PD-410 as a non-peptidic PET radiotracer for gastrin releasing peptide receptors, Ines Farinha-Antunes, Chantal Kwizera, Enza Lacivita, Ermelinda Lucente, Mauro Niso, Paola De Giorgio, Roberto Perrone, Nicola A. Colabufo, Philip H. Elsinga, Marcello Leopoldo, PP10 An improved nucleophilic synthesis of 2-(3,4-dimethoxyphenyl)-6-(2-[18F]fluoroethoxy) benzothiazole ([18F]FEDMBT), potential diagnostic agent for breast cancer imaging by PET, V.V. Vaulina, O.S. Fedorova, V.V. Orlovskaja, ?�.L. Chen, G.Y. Li, F.C. Meng, R.S. Liu, H.E. Wang, R.N. Krasikova, PP11 Internal radiation dose assessment of radiopharmaceuticals prepared with accelerator-produced 99mTc, Laura Meléndez-Alafort, Mohamed Abozeid, Guillermina Ferro-Flores, Anna Negri, Michele Bello, Nikolay Uzunov, Martha Paiusco, Juan Esposito, Antonio Rosato, PP12 A specialized five-compartmental model software for pharmacokinetic parameters calculation, Laura Meléndez-Alafort, Cristina Bolzati, Guillermina Ferro-Flores, Nicola Salvarese, Debora Carpanese, Mohamed Abozeid, Antonio Rosato, Nikolay Uzunov, PP13 Molecular imaging of the pharmacokinetic behavior of low molecular weight 18F-labeled PEtOx in comparison to 89Zr-labeled PEtOx, Palmieri L, Verbrugghen T, Glassner M, Hoogenboom R, Staelens S, Wyffels L, PP14 Towards nucleophilic synthesis of the α-[18F]fluoropropyl-L-dihydroxyphenylalanine, V. V. Orlovskaja, O. F. Kuznetsova, O. S. Fedorova, V. I. Maleev, Yu. N. Belokon, A. Geolchanyan, A. S. Saghyan, L. Mu, R. Schibli, S. M. Ametamey, R. N. Krasikova, PP15 A convenient one-pot synthesis of [18F]clofarabine, Revunov, Evgeny, Malmquist, Jonas, Johnström, Peter, Van Valkenburgh, Juno, Steele, Dalton, Halldin, Christer, Schou, Magnus, PP16 BODIPY-estradiol conjugates as multi-modality tumor imaging agents, Samira Osati,Michel Paquette,Simon Beaudoin,Hasrat Ali,Brigitte Guerin, Jeffrey V. Leyton, Johan E. van Lier, PP17 Easy and high yielding synthesis of 68Ga-labelled HBED-PSMA and DOTA-PSMA by using a Modular-Lab Eazy automatic synthesizer, Di Iorio V, Iori M, Donati C, Lanzetta V, Capponi PC, Rubagotti S, Dreger T, Kunkel F, Asti M, PP18 Synthesis and evaluation of fusarinine C-based octadentate bifunctional chelators for zirconium-89 labelling, Chuangyan Zhai, Christine Rangger, Dominik Summer, Hubertus Haas, Clemens Decristoforo, PP19 Fully automated production of [18F]NaF using a re-configuring FDG synthesis module., Suphansa Kijprayoon, Ananya Ruangma, Suthatip Ngokpol, Samart Tuamputsha, PP20 Extension of the Carbon-11 Small Labeling Agents Toolbox and Conjugate Addition, Ulrike Filp, Anna Pees, Carlotta Taddei, Aleksandra Pekošak, Antony D. Gee, Alex J. Poot, Albert D. Windhorst, PP21 In vitro studies on BBB penetration of pramipexole encapsulated theranostic liposomes for the therapy of Parkinson’s disease, Mine Silindir Gunay, A. Yekta Ozer, Suna Erdogan, Ipek Baysal, Denis Guilloteau, Sylvie Chalon, PP22 Factors affecting tumor uptake of 99mTc-HYNIC-VEGF165, Filippo Galli, Marco Artico, Samanta Taurone, Enrica Bianchi, Bruce D. Weintraub, Mariusz Skudlinski, Alberto Signore, PP23 Rhenium-188: a suitable radioisotope for targeted radiotherapy, Nicolas Lepareur, Nicolas Noiret, François Hindré, Franck Lacœuille, Eric Benoist, Etienne Garin, PP24 Preparation of a broad palette of 68Ga radiopharmaceuticals for clinical applications, Trejo-Ballado F, Zamora-Romo E, Manrique-Arias JC, Gama-Romero HM, Contreras-Castañon G, Tecuapetla-Chantes RG, Avila-Rodriguez MA, PP25 68Ga-peptide preparation with the use of two 68Ge/68Ga-generators, H. Kvaternik, D. Hausberger, C. Zink, B. Rumpf, R. M. Aigner, PP26 Assay of HEPES in 68Ga-peptides by HPLC, H. Kvaternik, D. Hausberger, B. Rumpf, R. M. Aigner, PP27 Preparation, in vitro and in vivo evaluation of a 99mTc(I)-Diethyl Ester (S,S)-Ethylenediamine- N,N´-DI-2-(3-Cyclohexyl) Propionic acid as a target-specific radiopharmaceutical, Drina Janković, Mladen Lakić, Aleksandar Savić, Slavica Ristić, Nadežda Nikolić, Aleksandar Vukadinović, Tibor J. Sabo, Sanja Vranješ-Đurić, PP28 90Y-labeled magnetite nanoparticles for possible application in cancer therapy, S. Vranješ-Đurić, M. Radović, D. Janković, N. Nikolić, G. F. Goya, P. Calatayud, V. Spasojević, B. Antić, PP29 Simplified automation of the GMP production of 68Ga-labelled peptides, David Goblet, Cristiana Gameiro, Neva Lazarova, PP30 Combining commercial production of multi-products in a GMP environment with Clinical & R&D activities, Cristiana Gameiro, Ian Oxley, Antero Abrunhosa, Vasko Kramer, Maria Vosjan, Arnold Spaans, PP31 99mTc(CO)3-labeling and Comparative In-Vivo Evaluation of Two Clicked cRGDfK Peptide Derivatives, Kusum Vats, Drishty Satpati, Haladhar D Sarma, Sharmila Banerjee, PP32 Application of AnaLig resin for 99mTc separation from molybdenum excess, Wojdowska W., Pawlak D.W., Parus L. J., Garnuszek P., Mikołajczak R., PP33 Constraints for selection of suitable precursor for one-step automated synthesis of [18F]FECNT, the dopamine transporter ligand, Pijarowska-Kruszyna J, Jaron A, Kachniarz A, Malkowski B, Garnuszek P, Mikolajczak R, PP34 Gamma scintigraphy studies with 99mTc- amoxicillin sodium in bacterially infected and sterile inflamed rats, Derya Ilem-Ozdemir, Oya Caglayan-Orumlu, Makbule Asikoglu, PP35 Preparation of 99mTc- Amoxicillin Sodium Lyophilized Kit, Derya Ilem-Ozdemir, Oya Caglayan-Orumlu, Makbule Asikoglu, PP36 Outfits of Tracerlan FXC-PRO for 11C-Labeling, Arponen Eveliina, Helin Semi, Saarinen Timo, Vauhkala Simo, Kokkomäki Esa, Lehikoinen Pertti, PP37 Microfluidic synthesis of ω-[18F]fluoro-1-alkynes, Mariarosaria De Simone, Giancarlo Pascali, Ludovica Carzoli, Mauro Quaglierini, Mauro Telleschi, Piero A. Salvadori, PP38 Automated 18F-flumazenil production using chemically resistant disposable cassettes, Phoebe Lam, Martina Aistleitner, Reinhard Eichinger, Christoph Artner, PP39 The effect of the eluent solutions (TBAHCO3, Kryptand K2.2.2) on the radiochemical yields of 18F-Fluoromethylcholine, Surendra Nakka, Hemantha Kumara MC, Al-Qahtani Mohammed, PP40 [68Ga]Radiolabeling of short peptide that has a PET imaging potentials, Al-Qahtani, Mohammed, Al-Malki, Yousif, PP41 Is validation of radiochemical purity analysis in a public hospital in a developing country possible?, N Mambilima, SM Rubow, PP42 Improved automated radiosynthesis of [18F]FEPPA, N. Berroterán-Infante, M. Hacker, M. Mitterhauser, W. Wadsak, PP43 Synthesis and initial evaluation of Al18F-RESCA1-TATE for somatostatin receptor imaging with PET, Uta Funke, Frederik Cleeren, Joan Lecina, Rodrigo Gallardo, Alfons M. Verbruggen, Guy Bormans, PP44 Radiolabeling and SPECT/CT imaging of different polymer-decorated zein nanoparticles for oral administration, Rocío Ramos-Membrive, Ana Brotons, Gemma Quincoces, Laura Inchaurraga, Inés Luis de Redín, Verónica Morán, Berta García-García, Juan Manuel Irache, Iván Peñuelas, PP45 An analysis of the quality of 68Ga-DOTANOC radiolabelling over a 3 year period, Trabelsi, M., Cooper M.S., PP46 In vivo biodistribution of adult human mesenchymal stem cells I (MSCS-ah) labeled with 99MTC-HMPAO administered via intravenous and intra-articular in animal model. Preliminary results, Alejandra Abella, Teodomiro Fuente, Antonio Jesús Montellano, Teresa Martínez, Ruben Rabadan, Luis Meseguer-Olmo, PP47 Synthesis of [18F]F-exendin-4 with high specific activity, Lehtiniemi P, Yim C, Mikkola K, Nuutila P, Solin O, PP48 Experimental radionuclide therapy with 177Lu-labelled cyclic minigastrin and human dosimetry estimations, von Guggenberg E, Rangger C, Mair C, Balogh L, Pöstényi Z, Pawlak D, Mikołajczak R, PP49 Synthesis of radiopharmaceuticals for cell radiolabelling using anion exchange column, Socan A, Kolenc Peitl P, Krošelj M, Rangger C, Decristoforo C, PP50 [68Ga]peptide production on commercial synthesiser mAIO, Collet C., Remy S., Didier R,Vergote T.,Karcher G., Véran N., PP51 Dry kit formulation for efficient radiolabeling of 68Ga-PSMA, D. Pawlak, M. Maurin, P. Garnuszek, U. Karczmarczyk, R. Mikołajczak, PP52 Development of an experimental method using Cs-131 to evaluate radiobiological effects of internalized Auger-electron emitters, Pil Fredericia, Gregory Severin, Torsten Groesser, Ulli Köster, Mikael Jensen, PP53 Preclinical comparative evaluation of NOTA/NODAGA/DOTA CYCLO-RGD peptides labelled with Ga-68, R. Leonte, F. D. Puicea, A. Raicu, E. A. Min, R. Serban, G. Manda, D. Niculae, PP54 Synthesizer- and Kit-based preparation of prostate cancer imaging agent 68Ga-RM2, Marion Zerna, Hanno Schieferstein, Andre Müller, Mathias Berndt, PP55 Synthesis of pancreatic beta cell-specific [18F]fluoro-exendin-4 via strain-promoted aza-dibenzocyclooctyne/azide cycloaddition, Cheng-Bin Yim, Kirsi Mikkola, Pirjo Nuutila, Olof Solin, PP56 Automated systems for radiopharmacy, D. Seifert, J. Ráliš, O. Lebeda, PP57 Simple, suitable for everyday routine use quality control method to assess radionuclidic purity of cyclotron-produced 99mTc, Svetlana V. Selivanova, Helena Senta, Éric Lavallée, Lyne Caouette, Éric Turcotte, Roger Lecomte, PP58 Effective dose estimation using Monte Carlo simulation for patients undergoing radioiodine therapy, Marina Zdraveska Kochovska, Emilija Janjevik Ivanovska, Vesna Spasic Jokic, PP59 Chemical analysis of the rituximab radioimmunoconjugates in lyophilized formulations intended for oncological applications, Darinka Gjorgieva Ackova, Katarina Smilkov, Petre Makreski, Trajče Stafilov, Emilija Janevik-Ivanovska, PP61 The need and benefits of established radiopharmacy in developing African countries, Aschalew Alemu, Joel Munene Muchira, David Mwanza Wanjeh, Emilija Janevik-Ivanovska, PP62 University Master Program of Radiopharmacy – step forward for Good Radiopharmacy Education, Emilija Janevik-Ivanovska, Zoran Zdravev, Uday Bhonsle, Osso Júnior João Alberto, Adriano Duatti, Bistra Angelovska, Zdenka Stojanovska, Zorica Arsova Sarafinovska, Darko Bosnakovski, Darinka Gorgieva-Ackova, Katarina Smilkov, Elena Drakalska, Meera Venkatesh, Rubin Gulaboski, PP63 Synthesis and preclinical validations of a novel 18F-labelled RGD peptide prepared by ligation of a 2-cyanobenzothiazole with 1,2-aminothiol to image angiogenesis., Didier J. Colin, James A. H. Inkster, Stéphane Germain, Yann Seimbille