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22 results on '"Kwon, Ki-Dong"'

12. Low-Temperature Thermal Decomposition of Industrial N-Hexane and Benzene Vapors

Author

Lee Joon-Yeob, Kwon Ki-Dong, Kang Jung-Hwan, Shin， Seung-ho, Kim Mo-Geun, and Jo， Wan-Kuen

Subjects
Hexane, chemistry.chemical_compound, Reaction temperature, chemistry, Transition metal, Inorganic chemistry, Thermal, Thermal decomposition, chemistry.chemical_element, Organic chemistry, Platinum, Benzene, Catalysis
Abstract

Present study evaluated the low-temperature destruction of n-hexane and benzene using mesh-type transition-metal platinum(Pt)/stainless steel(SS) catalyst. The parameters tested for the evaluation of catalytic destruction efficiencies of the two volatile organic compounds(VOC) included input concentration, reaction time, reaction temperature, and surface area of catalyst. It was found that the input concentration affected the destruction efficiencies of n-hexane and benzene, but that this input-concentration effect depended upon VOC type. The destruction efficiencies increased as the reaction time increased, but they were similar between two reaction times for benzene(50 and 60 sec), thereby suggesting that high temperatures are not always proper for thermal destruction of VOCs, when considering the destruction efficiency and operation costs of thermal catalytic system together. Similar to the effects of the input concentration on destruction efficiency of VOCs, the reaction temperature influenced the destruction efficiencies of n-hexane and benzene, but this temperature effect depended upon VOC type. As expected, the destruction efficiencies of n-hexane increased as the surface area of catalyst, but for benzene, the increase rate was not significant, thereby suggesting that similar to the effects of the re- action temperature on destruction efficiency of VOCs, high catalyst surface areas are not always proper for economical thermal destruction of VOCs. Depending upon the inlet concentrations and reaction temperatures, almost 100% of both n-hexane and benzene could be destructed, The current results also suggested that when applying the mesh type transition Metal Pt/SS catalyst for the better catalytic pyrolysis of VOC, VOC type should be considered, along with reaction temperature, surface area of catalyst, reaction time and input concentration.

Published
2006

17. 1507 NEUTRALIZING ANTIBODY FOR NERVE INJURY-INDUCED PROTEIN 1 RESTORES ERECTILE FUNCTION THROUGH ENHANCED CAVERNOUS ENDOTHELIAL REGENERATION IN THE STREPTOZOTOCIN-INDUCED DIABETIC MOUSE

Author

Ryu, Ji-Kan, primary, Yin, Guo Nan, additional, Kim, Woo Jean, additional, Jin, Hai-Rong, additional, Choi, Min Ji, additional, Song, Kang-Moon, additional, Kwon, Mi Hye, additional, Kwon, Ki-Dong, additional, Batbold, Dulguun, additional, and Suh, Jun-Kyu, additional

Published
2013
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22. Effect of SMAD7 gene overexpression on TGF-β1-induced profibrotic responses in fibroblasts derived from Peyronie's plaque.

Author

Choi MJ, Song KM, Park JM, Kwon MH, Kwon KD, Park SH, Ryu DS, Ryu JK, and Suh JK

Subjects
Cells, Cultured, Cyclin D1 drug effects, Cyclin D1 metabolism, Extracellular Matrix Proteins antagonists & inhibitors, Extracellular Matrix Proteins drug effects, Extracellular Matrix Proteins metabolism, Fibrosis chemically induced, Humans, Hydroxyproline antagonists & inhibitors, Hydroxyproline drug effects, Hydroxyproline metabolism, Male, Penile Induration drug therapy, Penile Induration physiopathology, Poly(ADP-ribose) Polymerases drug effects, Poly(ADP-ribose) Polymerases metabolism, Signal Transduction drug effects, Signal Transduction physiology, Smad7 Protein genetics, Smad7 Protein therapeutic use, Transfection, Transforming Growth Factor beta1 adverse effects, Transforming Growth Factor beta1 antagonists & inhibitors, Up-Regulation genetics, Fibroblasts drug effects, Fibroblasts pathology, Penile Induration pathology, Smad7 Protein physiology, Transforming Growth Factor beta1 pharmacology, Up-Regulation physiology
Abstract

Transforming growth factor-β1 (TGF-β1) has been identified as one of the most important fibrogenic cytokines associated with Peyronie's disease (PD). The mothers against decapentaplegic homolog 7 (SMAD7) is an inhibitory Smad protein that blocks TGF-β signaling pathway. The aim of this study was to examine the anti-fibrotic effect of the SMAD7 gene in primary fibroblasts derived from human PD plaques. PD fibroblasts were pretreated with the SMAD7 gene and then stimulated with TGF-β1. Treated fibroblasts were used for Western blotting, fluorescent immunocytochemistry, hydroxyproline determination, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assays. Overexpression of the SMAD7 gene inhibited TGF-β1-induced phosphorylation and nuclear translocation of SMAD2 and SMAD3, transdifferentiation of fibroblasts into myofibroblasts, and quashed TGF-β1-induced production of extracellular matrix protein and hydroxyproline. Overexpression of the SMAD7 gene decreased the expression of cyclin D1 (a positive cell cycle regulator) and induced the expression of poly (ADP-ribose) polymerase 1, which is known to terminate Smad-mediated transcription, in PD fibroblasts. These findings suggest that the blocking of the TGF-β pathway by use of SMAD7 may be a promising therapeutic strategy for the treatment of PD.

Published
2015
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