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1. Information Science Approaches to Scientific Information Systems and Their Implications to Scientific Researches.

Author

Kyushu Univ., Fukuoka (Japan). and Kitagawa, Tosio

Abstract

Some crucial aspects of international scientific information systems whose establishment will be urgently required in the near future are explored. The exploration is concerned with futuristic aspects of the coming thirty-two years of the present century. The main sections of this report cover: (1) descriptions of the cybernetic era; (2) aspects of information problems (function, system and coordination) and (3) discussions of a world scientific information network system. (MM)

Published
1969

2. Proton-3He Elastic Scattering at Intermediate Energies

Author

A., Watanabe (Tohoku Univ.), S., Nakai (Tohoku Univ.), Y., Wada (Tohoku Univ.), K., Sekiguchi (Tohoku Univ.), A., Deltuva (Inst. Theoretical Physics and Astronomy), T., Akieda (Tohoku Univ.), D., Etoh (Tohoku Univ.), M., Inoue (Tohoku Univ.), K., Kawahara (Tohoku Univ.), H., Kon (Tohoku Univ.), K., Miki (Tohoku Univ.), T., Mukai (Tohoku Univ.), D., Sakai (Tohoku Univ.), S., Shibuya (Tohoku Univ.), Y., Shiokawa (Tohoku Univ.), T., Taguchi (Tohoku Univ.), H., Umetsu (Tohoku Univ.), Y., Utsuki (Tohoku Univ.), M., Watanabe (Tohoku Univ.), S., Goto (Kyushu Univ.), K., Hatanaka (Osaka Univ., RCNP), Y., Hirai (Kyushu Univ.), T., Ino (KEK), D., Inomoto (Kyushu Univ.), A., Inoue (Osaka Univ., RCNP), S., Ishikawa (Hosei Univ.), M., Itoh (Tohoku Univ., CYRIC), H., Kanda (Osaka Univ., RCNP), H., Kasahara (Kyushu Univ.), N., Kobayashi (Osaka Univ., RCNP), Y., Maeda (Univ. Miyazaki), S., Mitsumoto (Kyushu Univ.), S., Nakamura (Osaka Univ., RCNP), K., Nonaka (Univ. Miyazaki), H., J. Ong (Osaka Univ., RCNP), H., Oshiro (Kyushu Univ.), Y., Otake (RIKEN), H., Sakai (RIKEN), A., Taketani (RIKEN), A., Tamii (Osaka Univ., RCNP), D., T. Tran (Osaka Univ., RCNP), T., Wakasa (Kyushu Univ.), Y., Wakabayashi (RIKEN), Wakui , T., Inoue, Y., and Takashi, Wakui

Subjects
Nuclear Theory, Nuclear Experiment
Abstract

We present a precise measurement of the cross section, proton and 3He analyzing powers, and spin correlation coefficient Cy,y for the p-3He elastic scattering near 65 MeV, and comparison with rigorous four-nucleon scattering calculations based on realistic nuclear potentials and a model with Δ-isobar excitation. Clear discrepancies are seen in some of the measured observables in the regime around the cross section minimum. Theoretical predictions using scaling relations between the calculated cross section and the 3He binding energy are not successful in reproducing the data. Large sensitivity to the NN potentials and rather small Δ-isobar effects in the calculated cross section are noticed as different features from those in the deuteron-proton elastic scattering. The results obtained above indicate that p-3He scattering at intermediate energies is an excellent tool to explore the nuclear interactions not accessible by the three-nucleon scattering.

Published
2021

3. How Different is the Core of 25F from 24Og.s. ?

Author

T., L. Tang (Univ. Tokyo, CNS), T., Uesaka (RIKEN), S., Kawase (Univ. Tokyo, CNS), D., Beaumel (Inst. Phys. Nucl. Orsay), M., Dozono (RIKEN), T., Fujii (Univ. Tokyo CNS), N., Fukuda (RIKEN), T., Fukunaga (Kyushu Univ.), A., Galindo-Uribarri (Oak Ridge Natl. Lab.), S., H. Hwang (Kyungpook Natl. Univ.), N., Inabe (RIKEN), D., Kameda (RIKEN), T., Kawahara (Toho Univ.), W., Kim ( Kyungpook Natl. Univ. ), K., Kisamori (Univ. Tokyo, CNS), M., Kobayashi (Univ. Tokyo, CNS), T., Kubo (RIKEN), Y., Kubota (Univ. Tokyo, CNS), K., Kusaka (RIKEN), C., S. Lee (Univ. Tokyo, CNS), Y., Maeda (Univ. Miyazaki), Wakui, Takashi, al., et, Takashi, Wakui, T., L. Tang (Univ. Tokyo, CNS), T., Uesaka (RIKEN), S., Kawase (Univ. Tokyo, CNS), D., Beaumel (Inst. Phys. Nucl. Orsay), M., Dozono (RIKEN), T., Fujii (Univ. Tokyo CNS), N., Fukuda (RIKEN), T., Fukunaga (Kyushu Univ.), A., Galindo-Uribarri (Oak Ridge Natl. Lab.), S., H. Hwang (Kyungpook Natl. Univ.), N., Inabe (RIKEN), D., Kameda (RIKEN), T., Kawahara (Toho Univ.), W., Kim ( Kyungpook Natl. Univ. ), K., Kisamori (Univ. Tokyo, CNS), M., Kobayashi (Univ. Tokyo, CNS), T., Kubo (RIKEN), Y., Kubota (Univ. Tokyo, CNS), K., Kusaka (RIKEN), C., S. Lee (Univ. Tokyo, CNS), Y., Maeda (Univ. Miyazaki), Wakui, Takashi, al., et, and Takashi, Wakui

Abstract

The structure of a neutron-rich F-25 nucleus is investigated by a quasifree (p, 2p) knockout reaction at 270A MeV in inverse kinematics. The sum of spectroscopic factors of pi 0d(5/2) orbital is found to be 1.0 +/- 0.3. However, the spectroscopic factor with residual O-24 nucleus being in the ground state is found to be only 0.36 +/- 0.13, while those in the excited state is 0.65 +/- 0.25. The result shows that the O-24 core of F-25 nucleus significantly differs from a free O-24 nucleus, and the core consists of similar to 35% O-24(g.s.). and similar to 65% excited O-24. The result may infer that the addition of the 0d(5/2) proton considerably changes neutron structure in F-25 from that in O-24, which could be a possible mechanism responsible for the oxygen dripline anomaly.

Published
2020

4. Aspects of Privacy for RFID Systems

Author

System LSI Research Center, Grad. Sch. Information Science & Electrical Engineering, Kyushu Univ., Japan, Inoue, Sozo, System LSI Research Center, Grad. Sch. Information Science & Electrical Engineering, Kyushu Univ., Japan, and Inoue, Sozo

Abstract

type:Presentation, International Workshop Series on RFID - Information Sharing and Privacy - November 10 and December 6, 2004, Tokyo University of Science, Tokyo, Japan

Published
2020

5. Is radical local therapy effective in postoperative recurrent EGFR‐mutated non‐small cell lung cancer?

Author

Tomoyoshi Takenaka, Tokujiro Yano, Koji Yamazaki, Tatsuro Okamoto, Motoharu Hamatake, Shinkichi Takamori, Mikihiro Kohno, Naoko Miura, Mototsugu Shimokawa, Tomoharu Yoshizumi, and Kyushu University Lung Surgery Study Group

Subjects
epidermal growth factor receptor mutation, non‐small cell lung cancer, post‐recurrence survival, recurrence, surgical resection, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Long‐term survival can be achieved with radical local therapy in some cases of postoperative recurrence of non‐small cell lung cancer (NSCLC). Here, we evaluated post‐recurrence survival (PRS) after treatment of postoperative recurrent epidermal growth factor receptor (EGFR) mutated NSCLC and examined the effectiveness of radical local therapy. Methods This multicenter prospective cohort study was conducted in 14 hospitals. The inclusion criteria for this study were patients with recurrence after radical resection for NSCLC. Information about the patient characteristics at recurrence, tumor‐related variables, primary surgery, and treatment for recurrence was collected. After registration, follow‐up data (e.g., treatment and survival outcomes) were obtained and analyzed. Results From 2010 to 2015, 505 patients with recurrent NSCLC were enrolled into the study, and 154 EGFR mutation‐positive cases were included. As the initial treatment for recurrence, 111 patients (72%) received chemotherapy, 14 (9%) received chemoradiotherapy, 14 (9%) received definitive radiotherapy, and seven (5%) received surgical resection. The remaining eight patients (5%) received supportive care. The median PRS and 5‐year survival rates for all cases were 64 months and 53.2%, respectively. The 5‐year survival rate according to the initial treatment was as follows: supportive care, 0%; chemotherapy, 53.3% and radical local therapy, 60.1%. The six patients who received radical local treatment remained recurrence‐free for more than 3 years after recurrence with only initial treatment. Conclusions Although radical local therapy may be curative in some patients, chemotherapy including EGFR‐TKI treatment is expected to provide long‐term survival comparable to that of radical local therapy.

Published
2023
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6. Fluid Dynamics for Global Environmental Studies

Author

Dept. Earth Sys Sci. Tech., Interdis.Grad Sch Engg Sci, Kyushu Univ and Dept. Earth Sys Sci. Tech., Interdis.Grad Sch Engg Sci, Kyushu Univ

Subjects
Environmental engineering--Mathematical models, Fluid dynamics--Mathematics
Abstract

This book introduces the basic concepts of environmental fluid dynamics. It is intended for use by students, researchers, engineers, and specialists working not only in general fluid research but also in the atmospheric and oceanic research fields. The Earth is covered by atmosphere and oceans and is exposed to solar wind. Therefore, the knowledge of fluid dynamics is essential for tackling its environmental issues. Although many textbooks have treated fluid dynamics, practically no book has been published that clearly describes all essential ideas, from the fundamentals of fluid dynamics to advanced environmental sciences, with careful sequential explanations of the governing mathematics. This book has been developed to solve these educational problems and has actually been in use in lectures in the graduate school of Kyushu University for more than 15 years.

Published
2017

7. An easy parameter estimation by the EM algorithm in the new up-and-down method

Author

Kyushu Univ. of Technol., Fukuoka (Kyushu institute of Technology, Kitakyushu, Japan), Komori, Yoshio, Hirose, Hideo, Kyushu Univ. of Technol., Fukuoka (Kyushu institute of Technology, Kitakyushu, Japan), Komori, Yoshio, and Hirose, Hideo

Abstract

type:Journal Article, Flashover voltage estimation has been carried out conventionally with the up-and-down method by Dixon and Mood. Recently, Hirose and Kato proposed a new version of the method to change the way of analyzing data. Although the method has better properties than the conventional one, it requires solving maximum likelihood equations. In this paper we reduce the troublesome task (e.g. implementation and the selection of a proper initial value) attendant on the requirement by using the expectation-maximization (EM) algorithm that gives a useful iterative formula to solve the equations. The iterative formula almost always can give the solutions of the likelihood equations because of its excellent global convergence of the EM algorithm

Published
2017

8. Inhomogeneous distribution of flux pinning strength and its effecton irreversibility line and vortex glass-liquid transition line in Bi-2212 tapes

Author

Graduate Sch. of Inf. Sci. & Electron. Eng., Kyushu Univ., Fukuoka, （Kyushu Institute of Technology, Fukuoka, Japan）, Kiuchi, Masaru, Matsushita, Teruo, Nakayama, Y, Takase, N, Graduate Sch. of Inf. Sci. & Electron. Eng., Kyushu Univ., Fukuoka, （Kyushu Institute of Technology, Fukuoka, Japan）, Kiuchi, Masaru, Matsushita, Teruo, Nakayama, Y, and Takase, N

Abstract

type:Journal Article, The irreversibility line and the vortex glass-liquid transition line under a magnetic field parallel to the c-axis are investigated for silver-sheathed and dip-coated Bi-2212 tape wires. It is found that the two characteristic lines for silver-sheathed tape is well explained by the flux creep-flow model assuming the distribution of pinning strength with a single peak. On the other hand, general agreements are obtained for these characteristic lines and the critical current density between experiments and theory only when two peaks are assumed in the distribution of flux pinning strength for the dip-coated tape. The causative structure in the dip-coated tape for the peak at small strength in the distribution is discussed, source:DOI: 10.1109/77.784828

Published
2017

9. Dependence on metalloid content for magnetic properties of Fe-Si-B metallic glasses

Author

Faculty of Engng., Kyushu Univ, Narita, K, Yamasaki, J, Fukunaga, H, Faculty of Engng., Kyushu Univ, Narita, K, Yamasaki, J, and Fukunaga, H

Abstract

type:Journal Article, On the splat-cooled metallic (Fe0.79Si0.21) 1-xBx glasses the concentration dependence of the magnetic properties has been investigated. For representative specimens, magnetic domain structures have been observed. The crystallization temperature increases and the Curie temperature monotonously decreases from 713K to 671K contrary to the result for reported Fe-P-C or Fe-P-B glasses as the metalloid content is increased. The highest value of crystallization temperature (797K) is about 150K higher than those for iron-rich glassy alloys reported up to now. The coercive force also depends on the boron content and the lowest value (0.04 Oe) has been obtained at about X=0.10. The magnetization process is discussed in the light of domain patterns observed

Published
2017

10. Composition dependence of magnetic moment and Curie temperature in amorphous (FexCo100-x)100-(y+z)Siy Bz ribbons

Author

Faculty of Engng., Kyushu Univ, Narita, K, Yamasaki, J, Fukunaga, H, Faculty of Engng., Kyushu Univ, Narita, K, Yamasaki, J, and Fukunaga, H

Abstract

type:Journal Article, Composition dependence of the magnetic moment and Curie temperature in amorphous (FexCo100-x)100-(y+z)SiyB z ribbons has been studied systematically with changing x, y, and z. A knee suggesting a peak was found in the magnetic moment vs. metalloid content curve for Fe-Si-B alloys, while the moment of Co-Si-B alloys decreases nearly linearly with increasing metalloid content. The moment of (FeCo)-Si-B alloys decreases monotonously with decreasing iron content. A clear peak in the Curie temperature vs. metalloid content curve was found not only for Fe-Si-B alloys but also for Co-Si-B alloys. The Curie temperature of (FeCo)-Si-B alloys peaks for varying iron content independently of the amount of total metalloid contained in the alloys. These behaviors are discussed in the framework of the Slater-Bethe's curve

Published
2017

11. Nucleation and Growth Control of ZnO via Impurity-mediated Crystallization

Author

KYUSHU UNIV FUKUOKA (JAPAN), Itagaki, Naho, KYUSHU UNIV FUKUOKA (JAPAN), and Itagaki, Naho

Abstract

The primary objective is to develop a fabrication method of ZnO based on magnetron sputtering, impurity-mediated crystallization (IMC) , where crystal nucleation and the growth are controlled by adsorbed impurities on the growth surface. By utilizing ZnO films prepared by IMC method as buffer layers (IMC buffer layers), two kinds of high-quality ZnO based semiconductors have been fabricated, the properties of which are superior to those of conventional ZnO films fabricated without IMC buffer layers.

Published
2015

12. Development of Odor Sensor to Recognize Partial Structures of Chemical Substances

Author

KYUSHU UNIV FUKUOKA (JAPAN), Toko, Kiyoshi, KYUSHU UNIV FUKUOKA (JAPAN), and Toko, Kiyoshi

Abstract

The aim of this research is to develop an odor sensor information system that can resolve molecular information into the information of partial structures, the so-called artificial olfactory epithelium. Furthermore an attempt was made to quantify odor using molecular information.

Published
2007

13. Microstructural Control of a Precipitate-Hardenable Al-Ag Alloy Using Severe Plastic Deformation

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF MATERIALS SCIENCE AND ENGINEERING, Ohashi, Kunihiro, Fujita, Takeshi, Oh-ishi, Keiichiro, Kaneko, Kenji, Horita, Zenji, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF MATERIALS SCIENCE AND ENGINEERING, Ohashi, Kunihiro, Fujita, Takeshi, Oh-ishi, Keiichiro, Kaneko, Kenji, and Horita, Zenji

Abstract

An Al-10.8wt%Ag alloy was subjected to aging treatment followed by Equal-Channel Angular Pressing (ECAP) (designated process AE) or ECAP followed by aging treatment (designated process EA). Hardness measurements were undertaken with respect to the number of ECAP passes for process AE or with respect to aging time for process EA. Microstructures were examined by transmission electron microscopy (TEM) including X-ray mapping. It is shown that age hardening is observed for the ECAP sample due to the precipitation of very fine particles within the small grains., Presented at International Conference on Processing and Manufacturing of Advanced Materials (THERMEC'2003) held in Leganes, Madrid, Spain on 7-11 July 2003. ISSN 0255-5476. ISBN 0-87849-919-9. This article is from ADA430670 International Conference on Processing and Manufacturing of Advanced Materials (THERMEC'2003) Part 3

Published
2004

14. Dynamical Behavior of Coupled Chaotic Oscillators Including Phase Synchronization and Complete Synchronization in Plasma

Author

KYUSHU UNIV FUKUOKA (JAPAN), Fukuyama, Takao, Kawai, Yoshinobu, KYUSHU UNIV FUKUOKA (JAPAN), Fukuyama, Takao, and Kawai, Yoshinobu

Abstract

The dynamical behavior of two coupled chaotic oscillators caused by the current-driven ion acoustic instability is experimentally studied. It is found that when two oscillators (two unstable waves) are interacting, and the dc potential applied to either of the two oscillators is varied gradually while maintaining coupling, the two oscillators synchronize in a certain region., Pub. in International Conference on Phenomena in Ionized Gases (26th), v4 p180-181, July 2003. This article is from ADA421147 International Conference on Phenomena in Ionized Gases (26th) Held in Greifswald, Germany on 15-20 July 2003. Proceedings, Volume 4

Published
2003

15. Controlling Chaos Caused by the Current-Driven Ion Acoustic Instability in a Laboratory Plasma Using Delayed Feedback

Author

KYUSHU UNIV FUKUOKA (JAPAN), Fukuyama, Takao, Taniguchi, Kazunari, Shirahama, Hiroyuki, Kawai, Yoshinobu, KYUSHU UNIV FUKUOKA (JAPAN), Fukuyama, Takao, Taniguchi, Kazunari, Shirahama, Hiroyuki, and Kawai, Yoshinobu

Abstract

Controlling chaos caused by the current-driven ion acoustic instability is attempted using the delayed continuous feedback method, i.e., the time-delay auto synchronization (TDAS) method introduced by Pyragas Phys. Lett. A 170 (1992) 421.J with flexibility., Pub. in International Conference on Phenomena in Ionized Gases (26th), v4 p178-179, July 2003. Prepared in cooperation with Dept. of Science, Kyoto University of Education, Japan; Division of Technology, Faculty of Education, Ehime, Japan. This article is from ADA421147 International Conference on Phenomena in Ionized Gases (26th) Held in Greifswald, Germany on 15-20 July 2003. Proceedings, Volume 4

Published
2003

16. Magnetism of Cobalt Base Artificial Lattice Films

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF MATERIALS SCIENCE AND ENGINEERING, Masuda, Masataka, Matsumoto, Shun, Taka, Kunihiko, Yoshitake, Naoki, Hayashi, Yasunori, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF MATERIALS SCIENCE AND ENGINEERING, Masuda, Masataka, Matsumoto, Shun, Taka, Kunihiko, Yoshitake, Naoki, and Hayashi, Yasunori

Abstract

The Co/Pd and Co/Pd artificial lattice films have attracted much interest by their special magnetization properties. We discussed the effect of the Pt, Pd layer thickness on the magnetic anisotropy, and we showed the effect of the hydrogen ion implantation on the magnetic properties of multi-layered films. The Co/Pt and Co/Pd multi-layered films were formed on Si(111) substrates with molecular beam epitaxy. We did structure analysis, magnetic domain analysis and magnetic properties evaluation with XRD, MFM and VSM, respectively. Among the series of films of 0.4 nm Co layer, XRD showed that the film of 1.0 nm Pt layer had a highest periodicity and that they had (111) plane orientation completely. The magnetic domain size reduced with the increase of the thickness of Pt layer. We found out that the coercivity decreased linearly as a function of the length of magnetic domain wall in the unit area. The result of VSM showed that the multi-layered films of Pt thickness of less than 2.8 nm had perpendicular magnetic anisotropy. The perpendicular anisotropy energy changed by the nonmagnetic layer thickness and had a maximum value for 0.4 nm Co 0.4 nm/nonmagnetic metal 1.0 nm multi-layered film. After hydrogen implantation into the films, XRD showed that the lattice spacing was swelled with hydrogen dose. Also, MFM observed that the magnetic domain size reduced with the increase of the hydrogen dose. The easy axis of magnetization changed from perpendicular to parallel in the plane with the increase of the hydrogen dose. After evacuation of hydrogen at 473 K, perpendicular anisotropy was partially recovered. This phenomenon suggested that the origin of magnetic anisotropy was mainly the lattice mismatch and distortion in the layer interface. But Co/Pd film was not recovered by this thermal treatment. This means that Pd made stable hydride and did not evacuate hydrogen at this temperature., Pub. in Materials Research Society symposium proceedings; v. 674 pT1.3.1-T1.3.6, 2001. This article is from ADA402512 Applications of Ferromagnetic and Optical Materials, Storage and Magnetoelectronics: Symposia Held in San Francisco, California, U.S.A. on April 16-20, 2001

Published
2001

17. Numerical Simulation of Rarefied Nozzle Plume Impingements

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF AERONAUTICS AND ASTRONAUTICS, Hyakutake, Toru, Nishide, Michio, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF AERONAUTICS AND ASTRONAUTICS, Hyakutake, Toru, and Nishide, Michio

Abstract

This paper describes numerical simulation of rarefied nozzle plume impingements. Two different reservoir pressures 400 kPa and 4 kPa are considered, In the case of 400 kPa, the simulation of the nozzle flow was conducted by using the Navier-Stokes equation and then the analysis of the plume flow was carried out by the DSMC method employing the nozzle exit conditions obtained by Navier-Stokes equation. On the other hand., for 4 kPa both the nozzle flow and the plume impingement have been calculated using the DSMC method. Concerning the angle between the nozzle axis and the flat plate, three kinds of angle are selected, that is 90 degrees, 45 degrees and 0 degrees. In addition, we considered the case where there exists a flat plate behind the nozzle. Simulated results have been compared with the existing experiments for the pressure and shear stress distributions on the flat plate. A good agreement between the DSMC results and the experiments are shown. In the case of the oblique and parallel impingements, the location of the impingement pressure peak and the stagnation point shifted upstream with increasing rarefaction., Papers from Rarefied Gas Dynamics (RGD) 22nd International Symposium held in Sydney, Australia on 9-14 July 2000. See also ADM001341 for whole conference on cd-rom.

Published
2000

18. Proceedings of JSASS 13th International Sessions in 37th Aircraft Symposium, Creative Flight - Growth and Evolution to the Future Generations - Aeronautics for the Twenty -First Century

Author

KYUSHU UNIV FUKUOKA (JAPAN) and KYUSHU UNIV FUKUOKA (JAPAN)

Abstract

Sampling of the 10 Sessions included the following: (1) A New Optimal Guidance Law for Short range Homing Missiles, (2) Effective Filtering of Target Glint, (3) Design of a Flight Control System for propulsion Controlled Aircraft, (4) Nonlinear Optimal in Helicopter Flight Control, (5) Flow Control Method Using Unsteady Sensitivity Analysis, (6) Simulation of A Flexible Aircraft Dynamics, (7) BVI Noise Predictions Using Euler/FW-H Method, (8) Suppression of Supersonic Jet Noise by Free Rotating Vane Type Tab, (9) An Accelerated Co-Evolutionary Algorithm Using Neural Networks, (10) A Study of the Swimming Path of the Penguin.

Published
1999

19. Interaction with Phospholipid Bilayers and Antibacterial Activity of Basic Alpha-Helical Amphipathic Peptides

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF CHEMISTRY, Aoyagi, Haruhiko, Lee, Sannamu, Aoki, Reiko, Park, Nam G., Ohno, Motonori, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF CHEMISTRY, Aoyagi, Haruhiko, Lee, Sannamu, Aoki, Reiko, Park, Nam G., and Ohno, Motonori

Abstract

We previously found that an amphipathic alpha-helical peptide Ac-(Leu-Ala-Arg-Leu)3-NHCH3 (4 sub 3) showed various biological activities and fused liposomes.

Published
1992

20. Molecular Properties of Lipopolysaccharide-Binding and Antimicrobial Tachyplesin I from Tachypleus Tridentatus

Author

KYUSHU UNIV FUKUOKA (JAPAN), Park, Nam G., Lee, Sannamu, Aoyagi, Haruhiko, Ohno, Motonori, Muta, Tatsushi, KYUSHU UNIV FUKUOKA (JAPAN), Park, Nam G., Lee, Sannamu, Aoyagi, Haruhiko, Ohno, Motonori, and Muta, Tatsushi

Abstract

This article is from 'Peptides. Chemistry and Biology: Proceedings of the American Peptide Symposium (12th) Held in Cambridge, Massachusetts on 16-21 June 1991', AD-A256 113, p250-252.

Published
1992

21. Non-Amphiphilic Analogs as Functional Probe of Biologically Active Amphiphilic Peptide: Exemplification in Gramicidin S

Author

KYUSHU UNIV FUKUOKA (JAPAN), Shimohigashi, Yasuyuki, Sakamoto, Hiroshi, Yoshitomi, Haruko, Waki, Michinori, Kawano, Keiichi, KYUSHU UNIV FUKUOKA (JAPAN), Shimohigashi, Yasuyuki, Sakamoto, Hiroshi, Yoshitomi, Haruko, Waki, Michinori, and Kawano, Keiichi

Abstract

This article is from 'Peptides. Chemistry and Biology: Proceedings of the American Peptide Symposium (12th) Held in Cambridge, Massachusetts on 16-21 June 1991', AD-A256 113, p271-272.

Published
1992

22. Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan.

Author

Masayuki Ochiai, Yuki Matsushita, Hirosuke Inoue, Takeshi Kusuda, Dongchon Kang, Kiyoshi Ichihara, Naoki Nakashima, Kenji Ihara, Shouichi Ohga, Toshiro Hara, and Kyushu University High-Risk Neonatal Clinical Research Network, Japan

Subjects
Medicine, Science
Abstract

Preterm low-birth-weight infants remain difficult to manage based on adequate laboratory tests. The aim of this study was to establish blood reference intervals (RIs) in those newborns who were admitted to and survived in the neonatal intensive care unit (NICU). A multicenter prospective study was conducted among all infants admitted to 11 affiliated NICUs from 2010 to 2013. The clinical information and laboratory data were registered in a network database designed for this study. The RIs for 26 items were derived using the parametric method after applying the latent abnormal values exclusion method. The influence of birth weight (BW) and gestational age (GA) on the test results was expressed in terms of the standard deviation ratio (SDR), as SDRBW and SDRGA, respectively. A total of 3189 infants were admitted during the study period; 246 were excluded due to a lack of blood sampling data, and 234 were excluded for chromosomal abnormalities (n = 108), congenital anomalies requiring treatment with surgical procedures (n = 76), and death or transfer to another hospital (n = 50). As a result, 2709 infants were enrolled in this study. Both the SDRGA and SDRBW were above 0.4 in the test results for total protein (TP), albumin (ALB), alanine aminotransferase (ALT), and red blood cells (RBC); their values increased in proportion to the BW and GA. We derived 26 blood RIs for infants who were admitted to NICUs. These RIs should help in the performance of proper clinical assessments and research in the field of perinatal-neonatal medicine.

Published
2016
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23. Taxonomic and Ecological Studies on the Lung Fluke, 'Paragonimus' in Central and South America.

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, Miyazaki,Ichiro, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, and Miyazaki,Ichiro

Abstract

Five species of freshwater crabs were collected at four localities in Panama, of which three species were identified as Potamocarcinus richmondi, Ptychophallus montanus cocleensis and Ptychophallus exilepes. The latter two species were new hosts of Paragonimus. Fifty-two or 18% of 293 crabs were infected with 105 Paragonimus metacercariae, which were separated into 13 A-forms, 91 B-forms and one C-form. The A-form was identified as Paragonimus peruvianus Miyazaki et al., 1969, and the B-form as P. caliensis Little, 1968, but the C-form was unknown. P. exilipes harbored mainly B-form, and the other crabs mainly A-form. The metacercaria of P. peruvianus was first found in Costa Rica at two localities mainly from Ptychophallus tristani and rarely from Potamocarcinus magnus., See also annual rept. no. 10, AD-767 753.

Published
1974

24. Wave Resistance of Vertical Cylinders with Ogival and Elliptical Water Planes

Author

KYUSHU UNIV FUKUOKA (JAPAN), Nakatake,K., Nishida,A., Yamazaki,R., KYUSHU UNIV FUKUOKA (JAPAN), Nakatake,K., Nishida,A., and Yamazaki,R.

Abstract

At the first workshop, the authors presented the results calculated by three kinds of low speed theories; (1) the modified low speed theory (MLST), (2) the conventional one (LST), and (3) Guevel's theory. Among them, the results of MLST agreed comparably well with Dawson's. He used the Rankine source and the same free surface condition as MLST for wall sided hull, as later pointed out by Mori. This fact encouraged us to adopt MLST and LST again for calculating the wave-resistance of the vertical cylinders with an ogival and an elliptical water planes. The authors also present the purely numerical results which are obtained by the fundamental equations of the low speed theory and Chan's finite difference scheme. Computations are made for the same vertical cylinders. Through the computations performed, the authors concluded that if the results obtained by the low speed theory are fin, the analytical method is still effective in evaluating wave-resistance, because the computer time is very short., This article is from 'Proceedings of the DTNSRDC (David W. Taylor Naval Ship Research and Development Center) Workshop on Ship Wave-Resistance Computations (2nd) Held at Bethesda, Maryland on 16-17 November 1983,' AD-A139 615, p406-421.

Published
1983

25. STRUCTURE AND FUNCTION OF INSECT PHOTORECEPTOR

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF BIOLOGY, Kuwabara, Masutara, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF BIOLOGY, and Kuwabara, Masutara

Abstract

The connections between the retinula cells of the compound eye and the neural elements in the optic lobe in fleshly (Boettcherisca peregrina) were observed by electron microscopy. The ommatidium consisted of eight retinula cells: six ordinary retinula cells, one central retinula cell and one basal retinula cell. The axons of ordinary retinula cells (short fibers) terminated at the lamina, whereas two extraordinary retinula cells extended their proximal axons (long fibers) to the medulla. Five or six short fibers crowded around two axons of monopolar ganglion cells at the lamina, constituting the neurommatidium where they held the repeated synaptic contacts with the monopolar axons. Many spherical invaginations were discovered at the axon membranes of short fiber in the neurommatidium. Such peculiar structures as well as the cytoarchitecture at the lamina were discussed in relation to possible functions.

Published
1966

26. Differentiation, Classification and Laboratory Diagnosis of El Tor Vibrios

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF BACTERIOLOGY, Takeya, Kenji, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF BACTERIOLOGY, and Takeya, Kenji

Abstract

Studies of kappa-type phage: The host range, serological properties and electron microscope morphology of kappa-type phage which is produced specifically by the Celebes type El Tor vibrio were investigated. Kappa-type phage inducing effects of ultraviolet light and mitomycin C were also examined. Lysogenicity of kappa-type phage in El Tor vibrio appeared to be unstable. A kappa-type phage detection method for rapid diagnosis of Celebes type El Tor vibrio carriers was deviced. Application of fluorescent antibody technique to cholera studies: Applicability and limitation of fluorescent antibody technique on diagnosis of cholera vibrio, and cross staining reaction of various vibrios including NAG vibrios and V. parahemolyticus with fluorescent antibody technique were surveyed. Biochemical properties of so-called water vibrios: Biochemical properties of 43 strains of water vibrios were studied and compared with those of known vibrio strains.

Published
1966

27. Changes in Electroencephalogram Spectra during Repeated Exposure to +Gz Acceleration.

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, Berkhout,Jan, O'Donnell,Robert D., Leverett,Sidney, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, Berkhout,Jan, O'Donnell,Robert D., and Leverett,Sidney

Abstract

Eight human subjects experienced a series of +Gz acceleration profiles reaching peak values of +41/2 Gz and +6 Gz. Each subject experienced six 45-second +Gz exposures within 15 minutes. Electroencephalograms (EEG) were made throughout this period and subjected to a narrow-band spectral analysis within 10-second epochs. The subjects wore protective G-suits, and did not experience impairment of central vision during the runs analyzed. Small increases in spectral intensity of the EEG were seen during eyes-closed, resting epochs following +Gz exposure. These increases did not change overall shape of spectral profiles and did not exceed normal levels of EEG intensity. During +Gz forces with eyes open, the raw EEG was dominated by electromyographic (EMG) activity, which was typically proportional to instantaneous +Gz force but might also reflect paroxysmal whole-body contractions occurring at scattered points in the +Gz exposure profile. Increased EEG intensities greatly exceeding basal levels for certain narrow frequency bands were observed during actual +Gz exposures. In all subjects, a return to normal EEG spectral intensity profiles took place within 30 seconds of termination of acceleration. (Modified author abstract), Prepared in cooperation with School of Aerospace Medicine, Brooks AFB, Tex.

Published
1973

28. Taxonomical and Ecological Studies on the Lung Fluke, 'Paragonimus' in the Pacific Area, with Special Reference to South-East Asia.

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, Miyazaki,Ichiro, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, and Miyazaki,Ichiro

Abstract

In Peru, two adult lung flukes were obtained from a 36-year-old Peruvian male, who had never been outside Peru and was suspected to have become infected near Aguaytia, a small town in Amazon area. The worms did not show their normal morphology due to bithionol. In Tingo Maria, about 60 kilometers from Aguaytia, an undescribed metacercaria of Paragonimus was found from one of 13 crabs, Pseudothelphusa chilensis collected in the university campus, and two persons living in the campus were positive for skin test, but negative for eggs. In Cajamarca northern part of Peru, P.caliensis was first recognized as the second lung fluke in this country. In Achiote, Colon Province, Panama, six of nine crabs, Pseudothelphusa richmondi were proved to be infected with Paragonimus metacercariae, which were separated into two species by their characteristics. The first species was identified as P.peruvianus, and the second one was presumed to belong to P.mexicanus. (Author)

Published
1972

29. Taxonomical and Ecological Studies on the Lung Fluke, Paragonimus in the Pacific Area, with Special Reference to South-East Asia.

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, Miyazaki,Ichiro, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, and Miyazaki,Ichiro

Abstract

In Japan, Angustassiminea nitida var. was found to be a new snail host for P. iloktsuenensis on Amami-Oshima Is. and for P ohirai on Tanegashimo Is. of Kagoshima Prefecture. By using a scanning electron microscope, the body surface of cercariae of P. miyazakii and P. iloktsuenensis as well as eggshells of P. kellicotti, P. mexicanus and P. peruvianus were clearly demonstrated. Outside Japan, P. macrorchis and P. siamensis were recognized in Ceylon, and Parathelphusa rugosa and ceylonensis were decided as the crab host for the former and the latter fluke, respectively. P. siamensis was recognized also in India. In Laos, adults of P. heterotremus were removed from the human lungs, showing medical importance of this fluke in Laos and in Thailand. In Korea, two forms of Paragonimus were noted from Eriocheir japonicus on Cheju Is. In Peru, the metacercaria of P. peruvianus was clarified for the first time, and it was concluded that the human disease in Cajamarca Province is not caused by P. westermani, but by the indigenous lung fluke, P. Peruvianus. (Author)

Published
1970

30. BIOPHYSICAL STUDIES OF THE INTESTINAL SMOOTH MUSCLE CELLS.

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PHYSIOLOGY, Toida,Naoki, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PHYSIOLOGY, and Toida,Naoki

Abstract

Various parts of the stomach smooth muscle membrane showed the similar passive properties with those observed in the intestine. Spontaneous discharges of spike appeared on a slow depolarization (slow wave). Tetrodotoxine and atropine decreased the amplitude of slow wave and then ceased the spike generation. On the other hand, MnCl2 blocked the spike generation first and then lowered the amplitude of the slow wave. The slow wave was reduced in amplitude by treatment with tetrodotoxine and atropine and enhanced by prostigmine. Chronaxie for the spike generation was 26 msec, condition velocity was 1.2 cm/sec and the time constant of the foot of the propagated spike was 28 msec. (Author)

Published
1968

31. TAXONOMICAL AND ECOLOGICAL STUDIES ON THE LUNG FLUKE, PARAGONIMUS IN THE PACIFIC AREA, WITH SPECIAL REFERENCE TO SOUTH-EAST ASIA.

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, Miyazaki,Ichiro, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PARASITOLOGY, and Miyazaki,Ichiro

Abstract

During past one year the following results were obtained: (1) As the host of P. miyazakii, a small snail, Bythinella nipponica akiyoshiensis was first determined by experiments. In addition, this snail was proved to be less susceptible to P. ohirai and non-susceptible to P. westermani. (2) The brown rat, Rattus norvegicus and the wild boar, Sus scrofa leucomystax were revealed to be the final host of P. miyazakii. (3) P. sadoensis was found as a new lung fluke on Sado Island, Niigata prefecture, which was proved to be able to mature in the albino rat, Rattus norvegicus, R. rattus, Mus molossinus and the dog. (4) Tricula minima was decided as the snail host of P. sadoensis. Its cercaria was first studied under the scanning electron microscope. (5) In Thailand, P. harinasutai was discovered as a new lung fluke, the metacercaria of which was abundantly parasitic in a crab, Potamon smithianus. Its egg was similar to that of P. westermani in morphology. (6) In Malaysia, two kinds of crab, Parathelphusa maculata and Potamicus cognatus were added to the list of the crab host for P. westermani. (7) In Indonesia, India and USSR, the existence of P. westermani was re-confirmed. (8) In Mexico, two species of Paragonimus were recognized, and one was most probably a new species and the other was similar to the new fluke found in Colombia. (Author)

Published
1968

32. ELECTROPHYSIOLOGICAL STUDY OF THE INTESTINAL SMOOTH MUSCLE OF THE GUINEA-PIG.

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PHYSIOLOGY, Toida,Naoki, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF PHYSIOLOGY, and Toida,Naoki

Abstract

Below 60 mV of membrane potential, overshoot potential and 11-18 V/sec of the maximum rate of rise of the spike were measured from various parts of longitudinal and circular muscles of the intestine. Conduction velocities of the longitudinal muscles of jejunum and rectum under tetrodotoxin were 2.1 and 4.0 cm/sec respectively and chronaxies of them were 2-5 and 5-18 msec respectively. Effective membrane resistance of the above two tissues was the same and showed 40-50 M ohms and time constant was 3-5 msec. Time constants measured by extracellular polarization were differed by the tissues. Relation between the membrane properties and morphological arrangements of the tissues was discussed. (Author)

Published
1966

33. DIFFERENTIATION, CLASSIFICATION AND LABORATORY DIAGNOSIS OF EL TOR VIBRIOS.

Author

KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF BACTERIOLOGY, Takeya,Kenji, KYUSHU UNIV FUKUOKA (JAPAN) DEPT OF BACTERIOLOGY, and Takeya,Kenji

Abstract

By the use of kappa-type phage, El Tor cholera vibrios were classified into 'Celebes type' and 'Classic-Ubon type', and the 'Celebes type' was further divided into 'Original' and 'Cured' strains. This phage-typing was applied to epidemiological studies. Biologic properties of 'Cured' strains and properties of phages liberated from Inaba type El Tor cholera vibrios and some Asiatic cholera vibrios were clarified. The kappa-type phage could be liberated from spheroplast form of Celebes type El Tor cholera vibrios cells, and its significance was discussed in relation to the detection of long-term carriers. Successful results of the application of phage detection method to carrier studies were described, and furthermore, a new phage-enrichment method for detection of long-term carriers was devised. The fluorescent antibody stainability of flagellum of El Tor cholera vibrio after heating or trichloracetic acid treatment was examined. (Author)

Published
1967

38. Space Plasma Environment

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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39. Environmental Fluid Dynamics

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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40. Dynamics of Stratified Fluids

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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41. Dynamics of Rotating Fluids

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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42. Turbulent Flow

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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43. Dynamics of Viscous Fluids

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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44. Dynamics of Perfect Fluids

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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45. Theory of Free Surface Waves

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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46. Fundamental Equations in Fluid Dynamics

Author

Department of Earth System Science and Technology, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University and Interdis.Grad Sch Engg Sci, Kyushu Univ., Dept. Earth Sys Sci. Tech.

Published
2017
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50. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Author

Tazeen H. Jafar, Lars Lind, Peter Almgren, Wendy Winckler, Eitaro Nakashima, Young Min Cho, Annette Peters, Rona J. Strawbridge, Ananda R. Wickremasinghe, Katharine R. Owen, Lee-Ming Chuang, Tien-Jyun Chang, Graeme I. Bell, James B. Meigs, Bill Musk, Timo A. Lakka, Elin Grundberg, Wei Lu, Sarah Edkins, George Dedoussis, Weiping Jia, Danish Saleheen, Suthesh Sivapalaratnam, Maria Samuel, Tien Yin Wong, Lu Qi, Pierre Fontanillas, Momoko Horikoshi, Jirong Long, Abdul Basit, Anubha Mahajan, Andrew T. Hattersley, Markus M. Nöthen, Denis Rybin, Inger Njølstad, S. Krithika, Miguel Cruz, Delilah Zabaneh, Leena Peltonen, Jasmina Kravic, Sangsoo Kim, David Couper, Lori L. Bonnycastle, Heather M. Stringham, Yi-Cheng Chang, Paul Elliott, Eric J.G. Sijbrands, Nita G. Forouhi, Alena Stančáková, Ghazala Mirza, Robert W. Lawrence, Ruth J. F. Loos, Norman Klopp, Shiro Maeda, Martina Müller-Nurasyid, Jer-Yuarn Wu, Jianjun Liu, Kee Seng Chia, Elodie Eury, Loukianos S. Rallidis, Timothy M. Frayling, Ken Yamamoto, David Altshuler, Gunnar Sigurosson, Harald Grallert, Jackie F. Price, Barbara Thorand, Jouko Saramies, Malene M. Kristensen, Sonali Pechlivanis, Inês Barroso, Jong-Young Lee, Melissa Parkin, Josée Dupuis, Stéphane Lobbens, Jesús Kumate, Elena Tremoli, Sudhir Kowlessur, Xueling Sim, Norihiro Kato, Philippe Froguel, Kathleen Stirrups, Eero Lindholm, Alex S. F. Doney, Andres Metspalu, Yu-Tang Gao, Roman Wennauer, Xiao-Ou Shu, Marilyn C. Cornelis, Veikko Salomaa, Nanette R. Lee, Johanna Kuusisto, Caroline S. Fox, Man Li, James Scott, Wing-Yee So, Andrew R. Wood, Inga Prokopenko, Oddgeir L. Holmen, Tin Aung, Ryoichi Takayanagi, Chen Suo, Hara Kazuo, Carl G. P. Platou, Ann M. Kelly, Teresa Ferreira, Karl-Heinz Jöckel, Wei-Yen Lim, James F. Wilson, Tom Forsén, Qi Sun, Valur Emilsson, Gonçalo R. Abecasis, Fan Zhang, Timo Saaristo, Harry Campbell, Ying Wu, Mark Seielstad, Wei Zheng, Han Chen, Stavroula Kanoni, Yuqian Bao, Jose C. Florez, Wan Ting Tay, Ronald C. WMa, Gerald Steinbach, Min Jin Go, Rong Zhang, Junbin Liang, Vasiliki Lagou, Leif Groop, Emil Rehnberg, Nabi Shah, Weihua Zhang, Yun Li, Bengt Sennblad, Olle Melander, Nancy L. Pedersen, Muhammed Islam, Jaakko Tuomilehto, Young Jin Kim, Richard N. Bergman, Juliana C.N. Chan, Eleftheria Zeggini, Andrew D. Johnson, Kees Hovingh, Joban Sehmi, Rainer Rauramaa, Satu Männistö, Reedik Mägi, Samuel Liju, Mingyu Yang, Ayellet V. Segrè, Noël P. Burtt, Mozhgan Dorkhan, Beverley Balkau, Neelam Hassanali, Hyun Min Kang, Fabrizio Veglia, Eeva Korpi-Hyövälti, Loic Yengo, Elizabeth J. Rossin, Angela Silveira, Maggie C.Y. Ng, Yuan-Tsong Chen, Anders Hamsten, David R. Matthews, Mark J. Caulfield, Emmi Tikkanen, Tanya M. Teslovich, John R. B. Perry, Karen L. Mohlke, Sarah E. Hunt, Soo Heon Kwak, Jorge Escobedo, Christopher J. Groves, Ulf de Faire, Jeremy B M Jowett, Gudmar Thorleifsson, Michael Roden, Evelin Mihailov, Viswanathan Mohan, Craig L. Hanis, Thomas WMühleisen, Congrong Wang, Sonia Shah, Kyle J. Gaulton, Jaspal S. Kooner, Jiro Nakamura, Mustafa Atalay, Linda S. Adair, S Wiltshire, Tõnu Esko, Anna Jonsson, Antigone S. Dimas, Karin Leander, Li Ching Chang, George B. Grant, Bo Isomaa, Anne U. Jackson, Claudia Langenberg, Kristian Hveem, Yoon Shin Cho, Astradur B. Hreidarsson, Xu Wang, Keizo Ohnaka, Alexandra C. Nica, Simon D. Rees, Pau Navarro, Sekar Kathiresan, Rob M. van Dam, Zafar I. Hydrie, Bok Ghee Han, Francis S. Collins, Fuu Jen Tsai, Unnur Thorsteinsdottir, Ross M. Fraser, Caroline Hayward, Cornelia M. van Duijn, Samuli Ripatti, Mieke D. Trip, Hyung Lae Kim, Rafn Benediktsson, Candace Guiducci, Bruna Gigante, Kyong Soo Park, Wen Hong L. Kao, Tom Wilsgaard, Leena Kinnunen, John Danesh, Alan James, Alan R. Shuldiner, Mitsuhiro Yokota, Jen Mai Lee, Kari Stefansson, Erik Ingelsson, Colin N. A. Palmer, David J. Hunter, Paul Zimmet, Manickam Chidambaram, Sirkka Keinänen-Kiukaanniemi, Laura J. Scott, Susanne Moebus, Benjamin F. Voight, Wolfgang Rathmann, Hassan Khan, Thomas Illig, Prasad Katulanda, Christian Gieger, Andrew D. Morris, Yik Ying Teo, Andrew P. Morris, Venkatesan Radha, N. William Rayner, Johan G. Eriksson, Christian Dina, Igor Rudan, Sailaja Vedantam, Cheng Hu, James S. Pankow, Ann-Christine Syvänen, Karl Gertow, Valeriya Lyssenko, Guillaume Charpentier, Albert Hofman, Chiea Chuen Khor, Joseph Trakalo, Peter Kraft, Takashi Kadowaki, Qiuyin Cai, John C. Chambers, André G. Uitterlinden, Simon C. Potter, Nicholas J. Wareham, Soumya Raychaudhuri, Jian'an Luan, Tiinamaija Tuomi, Anthony H. Barnett, Juha Saltevo, Robert A. Scott, Valgerdur Steinthorsdottir, Peng Keat Ng, Mark I. McCarthy, Åsa K. Hedman, Kerrin S. Small, Julia Meyer, Frank B. Hu, Cecilia M. Lindgren, Jennifer E. Below, Nancy J. Cox, Jennie Hui, Andrew Crenshaw, Latonya F. Been, Nam H. Cho, Janani Pinidiyapathirage, A. Samad Shera, Bernhard OBoehm, Jason Carey, Augustine Kong, Twee Hee Ong, Philippe M. Frossard, Donald W. Bowden, Toshimasa Yamauchi, Steve E. Humphries, Cordelia Langford, Xinzhong Li, Hiroshi Ikegami, Stéphane Cauchi, Ching-Ti Liu, Michael Boehnke, Peter M. Nilsson, Debashish Das, John Beilby, Robin Young, Christian Herder, Asif Rasheed, Neil Robertson, Raimund Erbel, Fumihiko Takeuchi, Markku Laakso, Esteban J. Parra, Panos Deloukas, Eric Boerwinkle, Adan Valladares-Salgado, Chien-Hsiun Chen, Kay-Tee Khaw, Damiano Baldassarre, Ashok Kumar, E. Shyong Tai, Peter S. Chines, Dharambir KSanghera, Peter Donnelly, [ 1 ] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England [ 2 ] Natl Inst Hlth, Ctr Genome Sci, Gangoe Myeon, Yeonje Ri, South Korea [ 3 ] Univ London Imperial Coll Sci Technol & Med, London, England [ 4 ] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA [ 5 ] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX1 2JD, England [ 6 ] NHLBI, Framingham Heart Study, Framingham, MA USA [ 7 ] Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC USA [ 8 ] Wake Forest Sch Med, Ctr Diabet Res, Winston Salem, NC USA [ 9 ] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London, England [ 10 ] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England [ 11 ] Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan [ 12 ] Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore [ 13 ] Wellcome Trust Sanger Inst, Cambridge, England [ 14 ] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA [ 15 ] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA [ 16 ] Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden [ 17 ] Univ Eastern Finland, Inst Biomed, Kuopio, Finland [ 18 ] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore [ 19 ] Natl Univ Singapore, Dept Ophthalmol, Singapore 117548, Singapore [ 20 ] IRCCS, Ctr Cardiol Monzino, Milan, Italy [ 21 ] Univ Milan, Dept Pharmacol Sci, Milan, Italy [ 22 ] INSERM, Ctr Rech Epidemiol & Sante Populat CESP, U1018, Villejuif, France [ 23 ] Univ Paris 11, UMRS 1018, Villejuif, France [ 24 ] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab, Shanghai Key Lab Diabet Mellitus,Shanghai Diabet, Shanghai 200030, Peoples R China [ 25 ] Univ Birmingham, Coll Med & Dent Sci, Birmingham, W Midlands, England [ 26 ] Heart England Natl Hlth Serv NHS Fdn Trust, Ctr Biomed Res, Birmingham, W Midlands, England [ 27 ] Univ Cambridge, Addenbrookes Hosp, Metab Res Labs, Inst Metab Sci, Cambridge CB2 2QQ, England [ 28 ] Addenbrookes Hosp, Inst Metab Sci, Cambridge Biomed Res Ctr, Natl Inst Hlth Res, Cambridge, England [ 29 ] Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan [ 30 ] Univ Oklahoma, Hlth Sci Ctr, Coll Med, Dept Pediat,Sect Genet, Oklahoma City, OK 73190 USA [ 31 ] Sir Charles Gairdner Hosp, Busselton Populat Med Res Inst, Nedlands, WA 6009, Australia [ 32 ] Queen Elizabeth II Med Ctr, PathWest Lab Med Western Australia, Nedlands, WA, Australia [ 33 ] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia [ 34 ] Univ Chicago, Dept Med, Chicago, IL 60637 USA [ 35 ] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA [ 36 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 37 ] Landspitali Univ Hosp, Reykjavik, Iceland [ 38 ] Cedars Sinai Med Ctr, Diabet & Obes Res Inst, Los Angeles, CA 90048 USA [ 39 ] Univ Med Ctr Ulm, Div Endocrinol & Diabet, Dept Internal Med, Ulm, Germany [ 40 ] Nanyang Technol Univ, Lee Kong Chian LKC Sch Med, Singapore 639798, Singapore [ 41 ] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA [ 42 ] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA [ 43 ] NHGRI, NIH, Bethesda, MD 20892 USA [ 44 ] Broad Inst Harvard & Massachusetts Inst Technol M, Cambridge, MA USA [ 45 ] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med, Nashville, TN 37212 USA [ 46 ] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland [ 47 ] Univ Edinburgh, Western Gen Hosp, MRC, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland [ 48 ] CNRS, Unite Mixte Rech UMR 8199, Inst Biol, Lille, France [ 49 ] Univ Lille 2, Inst Pasteur, Lille, France [ 50 ] Queen Mary Univ London, Barts & London Sch Med, William Harvey Res Inst, London, England [ 51 ] Queen Mary Univ London, Barts & London Sch Med, William Harvey Res Inst, Barts & London Genome Ctr, London, England [ 52 ] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China [ 53 ] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan [ 54 ] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan [ 55 ] Corbeil Essonnes Hosp, Endocrinol Diabetol Unit, Corbeil Essonnes, France [ 56 ] China Med Univ, Sch Chinese Med, Taichung, Taiwan [ 57 ] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA [ 58 ] Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117548, Singapore [ 59 ] Indian Council Med Res, Adv Ctr Genom Diabet, Madras Diabet Res Fdn, Dept Mol Genet, Madras, Tamil Nadu, India [ 60 ] Ajou Univ, Sch Med, Dept Prevent Med, Suwon 441749, South Korea [ 61 ] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea [ 62 ] Natl Taiwan Univ, Sch Med, Grad Inst Clin Med, Taipei 10764, Taiwan [ 63 ] Harvard Univ, Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA 02115 USA [ 64 ] Univ N Carolina, Dept Biostat, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA [ 65 ] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore [ 66 ] Ealing Hosp NHS Trust, Southall, Middx, England [ 67 ] Karolinska Inst, Inst Environm Med, Divis Cardiovasc Epidemiol, S-10401 Stockholm, Sweden [ 68 ] Harokopio Univ, Dept Dietet Nutr, Athens, Greece [ 69 ] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland [ 70 ] Biomed Sci Res Ctr Alexander Fleming, Vari, Greece [ 71 ] INSERM, UMR 1087, Nantes, France [ 72 ] CNRS, UMR 6291, Nantes, France [ 73 ] Univ Nantes, Nantes, France [ 74 ] Univ Dundee, Ninewells Hosp, Biomed Res Inst, Diabet Res Ctr, Dundee, Scotland [ 75 ] Univ Dundee, Ninewells Hosp, Biomed Res Inst, Pharmacogen Ctr, Dundee, Scotland [ 76 ] Univ Oxford, Dept Stat, Oxford OX1 3TG, England [ 77 ] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands [ 78 ] Netherlands Consortium Healthy Ageing, Netherland Genom Initiat, Rotterdam, Netherlands [ 79 ] Ctr Med Syst Biol, Rotterdam, Netherlands [ 80 ] Univ London Imperial Coll Sci Technol & Med, MRC, Hlth Protect Agcy, Ctr Environm & Hlth, London, England [ 81 ] Iceland Heart Assoc, Kopavogur, Iceland [ 82 ] Univ Duisburg Essen, Univ Hosp Essen, West German Heart Ctr, Clin Cardiol, Essen, Germany [ 83 ] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland [ 84 ] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland [ 85 ] Univ Helsinki, Gen Hosp, Unit Gen Practice, Helsinki, Finland [ 86 ] Folkhalsan Res Ctr, Helsinki, Finland [ 87 ] Inst Mexicano Seguro Social, Hosp Gen Reg 1, Unidad Invest Epidemiol Clin, Mexico City, DF, Mexico [ 88 ] Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia [ 89 ] Univ Tartu, Inst Mol & Cell Biol, EE-50090 Tartu, Estonia [ 90 ] Broad Inst, Program Med & Populat Genet, Cambridge, MA USA [ 91 ] Childrens Hosp, Div Genet & Endocrinol, Boston, MA 02115 USA [ 92 ] Harvard Univ, Sch Med, Dept Med, Boston, MA USA [ 93 ] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA [ 94 ] Massachusetts Gen Hosp, Diabet Res Ctr, Diabet Unit, Boston, MA 02114 USA [ 95 ] Addenbrookes Hosp, Inst Metab Sci, MRC, Epidemiol Unit, Cambridge, England [ 96 ] Vaasa Hlth Care Ctr, Vaasa, Finland [ 97 ] Brigham & Womens Hosp, Div Endocrinol & Metab, Boston, MA 02115 USA [ 98 ] Harvard Univ, Sch Med, Boston, MA USA [ 99 ] Univ Exeter, Peninsula Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England [ 100 ] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China [ 101 ] Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden [ 102 ] Karolinska Univ, Hosp Solna, Ctr Mol Med, Stockholm, Sweden [ 103 ] Helmholtz Zentrum Muenchen, Inst Genet Epidemiol, Neuherberg, Germany [ 104 ] Helmholtz Zentrum Muenchen, Res Unit Mol Epidemiol, Neuherberg, Germany [ 105 ] Univ Munich, Clin Cooperat Grp Diabet, Munich, Germany [ 106 ] Helmholtz Zentrum Muenchen, Munich, Germany [ 107 ] Tech Univ Munich, Clin Cooperat Grp Nutrigen & Type Diabet 2, Munich, Germany [ 108 ] German Ctr Diabet Res DZD, 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Subjects
CHROMATIN, endocrine system diseases, South Asian Type 2 Diabetes (SAT2D) Consortium, SCALE ASSOCIATION ANALYSIS, Medizin, LOCI, Genome-wide association study, VARIANTS, 0302 clinical medicine, Risk Factors, IMPUTATION, Glucose homeostasis, 11 Medical and Health Sciences, Genetics & Heredity, Genetics, 0303 health sciences, IDENTIFY, Hispanic or Latino, 3. Good health, MAP, POPULATIONS, Medical genetics, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, Hispanic Americans, Life Sciences & Biomedicine, Asian Continental Ancestry Group, medicine.medical_specialty, European Continental Ancestry Group, TRANSETHNIC METAANALYSIS, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Article, White People, Sykursýki, 03 medical and health sciences, Asian People, SDG 3 - Good Health and Well-being, medicine, Humans, Genetic Predisposition to Disease, Allele, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, Alleles, 030304 developmental biology, Genetic association, Science & Technology, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, 06 Biological Sciences, Arfgengi, Genetic architecture, INDIVIDUALS, Diabetes Mellitus, Type 2, Case-Control Studies, GLUCOSE-HOMEOSTASIS, ASSOCIATION ANALYSES, Imputation (genetics), Developmental Biology, Genome-Wide Association Study
Abstract

To access publisher's full text version of this article click on the hyperlink at the bottom of the page To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry. Canadian Institutes of Health Research Medical Research Council UK G0601261 Mexico Convocatoria SSA/IMMS/ISSSTE-CONACYT 2012-2 clave 150352 IMSS R-2011-785-018 CONACYT Salud-2007-C01-71068 US National Institutes of Health DK062370 HG000376 DK085584 DK085545 DK073541 DK085501 Wellcome Trust WT098017 WT090532 WT090367 WT098381 WT081682 WT085475 info:eu-repo/grantAgreement/EC/FP7/201413

Published
2014
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