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Photodynamic therapy (PDT) has been shown to be useful and effective in the treatment of actinic keratosis, Bowen disease, and basal cell carcinoma. We present a series of 13 Bowen disease lesions treated using PDT. Complete responses were achieved in 11 (84%) of the lesions after 3 months of treatment; at 18 months, complete responses were seen in 9 (70%) of the lesions. Patients who presented a partial response or recurrence were treated with topical 5% imiquimod and achieved complete responses. The lesions that presented partial response or recurrence were the largest lesions, between 3 and 5cm in diameter. PDT in monotherapy or combined sequentially with imiquimod is an excellent and well-tolerated therapeutic option for Bowen disease. The treatment has few adverse effects and shows satisfactory results, particularly in multiple large lesions in areas of difficult surgical reconstruction or in elderly patients with a high surgical risk.

Dermatologic manifestations of leukemia can be both specific and nonspecific (e.g., opportunistic infections, purpura and ecchymosis, Sweet syndrome). Leukemia cutis refers to the infiltration of the skin with neoplastic leukocytes and its early diagnosis has important prognostic implications. We report on 17 cases of leukemia cutis seen in our department between 1994 and 2014 and describe the characteristics of the patients (age, sex, medical history), the morphology of the lesions, and associations with systemic disease. Most of the patients were male and the most common associated malignancy was acute myeloid leukemia. The most frequent dermatologic manifestations were nodules or erythematous papules on the limbs. We describe our experience with the diagnosis and management of leukemia cutis over a period of 20 years and emphasize the importance of clinical signs in the early diagnosis of this condition.

Resumen Las manifestaciones dermatologicas de las leucemias incluyen lesiones especificas e inespecificas (infecciones oportunistas, purpura y equimosis, sindrome de Sweet, etc.). La infiltracion de leucocitos neoplasicos en la piel se conoce como leucemia cutis, y es de especial interes el diagnostico por su implicacion pronostica. Hemos recogido los casos de leucemia cutis en nuestro servicio entre 1994 y 2014, con un total de 17 pacientes, y hemos evaluado sus caracteristicas (edad, sexo, historia medica), la morfologia de las lesiones y su relacion con la enfermedad sistemica. En nuestra serie la mayoria de los pacientes fueron varones, y la asociacion mas frecuente fue con leucemia mieloide aguda y se presento como nodulos o papulas eritematosas en las extremidades de forma mayoritaria. Presentamos nuestra experiencia en el diagnostico y manejo de esta entidad en los ultimos 20 anos, llamando la atencion sobre las caracteristicas clinicas para un diagnostico precoz.

Lentigo maligna is the most common form of in situ melanoma. It is most often found on the head and neck, and its clinical and dermoscopic features in this location have been extensively described in the literature. We present a series of 14 patients diagnosed with extrafacial lentigo maligna and lentigo maligna melanoma at Hospital General de Valencia and Hospital de Manacor in Spain, and describe the clinical, dermoscopic, and histologic features observed. Most of the melanomas were located on the upper limbs; the next most common locations were the trunk and the lower limbs. The dermoscopic patterns were consistent with facial lentigo maligna and superficial spreading melanoma. Extrafacial lentigo maligna is uncommon. It has similar clinical and histologic features to facial lentigo, but dermoscopy may show a mix of patterns typically seen in lentigo maligna and superficial spreading melanoma. This difference in dermoscopic features is essentially due to anatomical differences between skin on the face and on other parts of the body.

Resumen El lentigo maligno es actualmente la variante mas frecuente de melanoma in situ . Se localiza principalmente en la cabeza y el cuello, donde sus caracteristicas clinicas y dermatoscopicas estan descritas ampliamente en la literatura. Presentamos una serie de 14 pacientes diagnosticados de lentigo maligno y lentigo maligno melanoma extrafacial en el Hospital General de Valencia y Hospital de Manacor, describiendo los hallazgos clinicos, dermatoscopicos e histologicos de los mismos. La localizacion mas frecuentemente encontrada fue las extremidades superiores, seguida del tronco y las extremidades inferiores. En la dermatoscopia se hallaron patrones compatibles con lentigo maligno facial y melanoma de extension superficial. La localizacion extracefalica de los lentigos malignos es poco frecuente. Clinica e histologicamente muestra caracteristicas semejantes al de localizacion facial, aunque en la dermatoscopia podemos encontrar una mezcla de patrones de lentigo maligno y melanoma de extension superficial, debido principalmente a las diferencias entre las caracteristicas anatomicas de la piel facial y la extrafacial.

Erythema elevatum diutinum may be confused with Sweet syndrome, Kaposi sarcoma, or bacillary angiomatosis.

Dermatologic manifestations of leukemia can be both specific and nonspecific (e.g., opportunistic infections, purpura and ecchymosis, Sweet syndrome). Leukemia cutis refers to the infiltration of the skin with neoplastic leukocytes and its early diagnosis has important prognostic implications. We report on 17 cases of leukemia cutis seen in our department between 1994 and 2014 and describe the characteristics of the patients (age, sex, medical history), the morphology of the lesions, and associations with systemic disease. Most of the patients were male and the most common associated malignancy was acute myeloid leukemia. The most frequent dermatologic manifestations were nodules or erythematous papules on the limbs. We describe our experience with the diagnosis and management of leukemia cutis over a period of 20 years and emphasize the importance of clinical signs in the early diagnosis of this condition.

Lentigo maligna is the most common form of in situ melanoma. It is most often found on the head and neck, and its clinical and dermoscopic features in this location have been extensively described in the literature. We present a series of 14 patients diagnosed with extrafacial lentigo maligna and lentigo maligna melanoma at Hospital General de Valencia and Hospital de Manacor in Spain, and describe the clinical, dermoscopic, and histologic features observed. Most of the melanomas were located on the upper limbs; the next most common locations were the trunk and the lower limbs. The dermoscopic patterns were consistent with facial lentigo maligna and superficial spreading melanoma. Extrafacial lentigo maligna is uncommon. It has similar clinical and histologic features to facial lentigo, but dermoscopy may show a mix of patterns typically seen in lentigo maligna and superficial spreading melanoma. This difference in dermoscopic features is essentially due to anatomical differences between skin on the face and on other parts of the body.

We present a case report of a patient with epidermal inclusion cyst as a late complication of female genital mutilation (FGM). We describe the management of the patient, and a review of the literature. We report the clinical and pathological findings in a 37-year-old female patient from Nigeria, with a clitoral mass of 1 year duration. She declared to have an FGM since she was 5 years. The lesion was excised successfully with good cosmetic results. Histological examination revealed epidermal cyst with the presence of granular layer. An epidermal inclusion cyst can develop as a long-term consequence of FGM.