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1. RNTuple: Towards First-Class Support for HPC data centers

Author

Miotto, Giovanna Lazzari and Lopez-Gomez, Javier

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Physics - Accelerator Physics, Physics - Computational Physics, H.3.0, E.2, J.2
Abstract

Compared to LHC Run 1 and Run 2, future HEP experiments, e.g., at the HL-LHC, will increase the volume of generated data by an order of magnitude. In order to sustain the expected analysis throughput, ROOT's RNTuple I/O subsystem has been engineered to overcome the bottlenecks of the TTree I/O subsystem, focusing also on a compact data format, asynchronous and parallel requests, and a layered architecture that allows supporting distributed filesystem-less storage systems, e.g. HPC-oriented object stores. In a previous publication, we introduced and evaluated the RNTuple's native backend for Intel DAOS. Since its first prototype, we carried out a number of improvements both on RNTuple and its DAOS backend aiming to saturate the physical link, such as support for vector writes and an improved RNTuple-to-DAOS mapping, only to name a few. In parallel, the latest developments allow for better integration between RNTuple and ROOT's storage-agnostic, declarative interface to write HEP analyses, RDataFrame. In this work, we contribute with the following: (i) a redesign of the RNTuple DAOS backend, including a mechanism for efficient population of the object store based on existing data; and (ii) an experimental evaluation on a single-node platform, showing a significant increase in the analysis throughput for typical HEP workflows., Comment: 21st International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT 2022), 5 pages

Published
2023

3. RNTuple performance: Status and Outlook

Author

Lopez-Gomez, Javier and Blomer, Jakob

Subjects
Physics - Data Analysis, Statistics and Probability, Computer Science - Databases, Physics - Accelerator Physics, Physics - Computational Physics, H.3.0, E.2, J.2
Abstract

Upcoming HEP experiments, e.g. at the HL-LHC, are expected to increase the volume of generated data by at least one order of magnitude. In order to retain the ability to analyze the influx of data, full exploitation of modern storage hardware and systems, such as low-latency high-bandwidth NVMe devices and distributed object stores, becomes critical. To this end, the ROOT RNTuple I/O subsystem has been designed to address performance bottlenecks and shortcomings of ROOT's current state of the art TTree I/O subsystem. RNTuple provides a backwards-incompatible redesign of the TTree binary format and access API that evolves the ROOT event data I/O for the challenges of the upcoming decades. It focuses on a compact data format, on performance engineering for modern storage hardware, for instance through making parallel and asynchronous I/O calls by default, and on robust interfaces that are easy to use correctly. In this contribution, we evaluate the RNTuple performance for typical HEP analysis tasks. We compare the throughput delivered by RNTuple to popular I/O libraries outside HEP, such as HDF5 and Apache Parquet. We demonstrate the advantages of RNTuple for HEP analysis workflows and provide an outlook on the road to its use in production., Comment: 5 pages, 5 figures; submitted to proceedings of 20th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT 2021)

Published
2022
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4. Exploring Object Stores for High-Energy Physics Data Storage

Author

López-Gómez, Javier and Blomer, Jakob

Subjects
Computer Science - Databases, High Energy Physics - Experiment
Abstract

Over the last two decades, ROOT TTree has been used for storing over one exabyte of High-Energy Physics (HEP) events. The TTree columnar on-disk layout has been proved to be ideal for analyses of HEP data that typically require access to many events, but only a subset of the information stored for each of them. Future colliders, and particularly HL-LHC, will bring an increase of at least one order of magnitude in the volume of generated data. Therefore, the use of modern storage hardware, such as low-latency high-bandwidth NVMe devices and distributed object stores, becomes more important. However, TTree was not designed to optimally exploit modern hardware and may become a bottleneck for data retrieval. The ROOT RNTuple I/O system aims at overcoming TTree's limitations and at providing improved efficiency for modern storage systems. In this paper, we extend RNTuple with a backend that uses Intel DAOS as the underlying storage, demonstrating that the RNTuple architecture can accommodate high-performance object stores. From the user perspective, data can be accessed with minimal changes to the code, that is by replacing a filesystem path by a DAOS URI. Our performance evaluation shows that the new backend can be used for realistic analyses, while outperforming the compatibility solution provided by the DAOS project., Comment: Accepted for Proceedings of 25th International Conference on Computing in High-Energy and Nuclear Physics

Published
2021
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5. Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Author

Abdallah, A, Abentroth, AL, Acheimastos, V, Agunaoun, M, Al Bisher, HM, Al Ghuzlan, A, Alakus, H, Alkan, M, Almaraz Almaraz, MC, Amram, K, Anesidis, S, Anestiadou, E, Angelucci, D, Ansaldo, GL, Antonopoulou, MI, Arciniegas, M, Armellin, C, Arredondo Saldaña, G, Astl, J, Athanasakis, E, Avenia, S, Aydın, H, Baba, B, Babala, J, Banús, MV, Barba-Valadez, LA, Barcons, SV, Battafarano, F, Bayat, A, Bella, RMC, Benariba, F, Bernardi, S, Bignami, EG, Bitenc, M, Bitsianis, S, Bolaños de la Torre, JDD, Bonati, E, Bonetti, T, Borges, FA, Bouchagier, K, Boudina, M, Bourial, A, Breuskin, I, Brock, P, Bruns, C, Burlacu, MC, Burton, T, Buta, M, Buzanakov, D, Caliseo, C, Callanan, D, Calu, V, Cameselle-Teijeiro, JM, Camilo-Junior, DJ, Canberk, S, Candalise, V, Candanedo-Gonzalez, F, Carrillo Lizarazo, LJ, Carvalho, GB, Casallas, D, Casolino, C, Castellani, L, Castillo Morales, C, Chambon, G, Chatzipavlidou, V, Chernikov, R, Chorti, A, Chow, TCM, Chrisoulidou, A, Chrysos, E, Conrado-Neto, S, Cordova García, D, Corigliano, A, Crocco, A, Cuesta, A, Čukman, M, Curto, LS, Damilano, RA, D'Anna, R, De, M, De Virgilio, A, Dellaportas, D, Demarquet, L, Devresse, A, Di Meo, G, Diaz Pedrero, R, Dimitrov, D, Dmitry, Z, Domínguez Garijo, P, Dulgeroglu, O, Dural, AC, Eksi, A, El Hammoumi, M, El Kaoui, H, Eleni, G, Elliyanti, A, Ersöz, Ş, Escobar-Jiménez, M, Fedorova, L, Feeley, L, Fernández Rodríguez, E, Ferreli, F, Filoia, A, Fingeret, A, Francescato, A, Gaino, F, Galiandro, F, Gallegos-Hernández, JF, Garas, G, García Lorenzo, F, García-Chávez, JP, Gaudiello, M, Gay, S, Gerasimos, S, Gerek, M, Gervasi, R, Giordano, A, Gjeloshi, B, Gocký, L, Golubinskaya, E, González Romero, S, González-Mínguez, C, Goran, M, Gosman, A, Granados Garcia, M, Greco, E, Grünbart, M, Grützmann, R, Guerlain, J, Guirao, XG, Guzey, D, Hajjij, A, Hamdy, O, Hameed, MS, Hauth, LA, Hernández-Acevedo, JD, Hernandez-Carrillo, JF, Hevilla Sánchez, F, Hoi, H, Hongkwon, K, Hu Zhu, R, Huang, E, Hyeung Kyoo, K, Ignjatovic, V, Ioannidis, A, Iossa, A, Işık, A, James, D, Jung Hoon, L, Kara, H, Karajovic, J, Kartini, D, Khambri, D, Kholová, I, Kisiel, M, Knežević, M, Koh, YQ, Konca, C, Kosmidis, C, Kotsovolis, G, Kowalski, LP, Kralik, R, Kuczma, P, Kuravi, BG, Kurnia, A, Kyriaki, V, Lai, CM, Lallemant, B, Lardhi, AA, Leboulleux, S, Lee, JW, Lelli, G, Leutner, M, Lim, MY, Lim, CM, Llanos, A, Lo, X, Loderer, T, López-Corrales, MA, Ludwig, M, Magnabosco, FF, Maheo, C, Maia, AL, Makay, O, Maksimova, P, Mallick, S, Mallouk, C, Mamani, Z, Mandal, S, Manyalich Blasi, M, Marincola, G, Marulanda, M, Mavromati, M, Mayilvaganan, S, Metso, S, Micalizzi, A, Michalopoulos, A, Min-Su, K, Miron, A, Mishra, AK, Misso, C, Mittermair, C, Morosán Allo, Y, Mourad, M, Moysidis, M, Nabhan, F, Nasiri, R, Nastos, C, Ngiam, KY, Nomine-Criqui, C, Ntziovara, AM, Nuño Vázquez-Garza, JM, Nutautiene, V, Obtulovičová, K, O'Keeffe, L, Okudur, NO, Ossola, P, Ovejero Merino, E, Ozdemir, M, Pangonis, A, Panigoro, SS, Panuzi, A, Papaconstantinou, D, Pardo Matamoros, N, Paschou, S, Pasculli, A, Paterakis, K, Peiris, K, Pennestrì, F, Peppa, M, Perdikaris, P, Perdikaris, I, Pérez-Soto, RH, Piana, S, Piccoli, M, Pietrasanta, D, Placentino, G, Pliakos, I, Polistena, A, Pongtippan, A, Potard, G, Quinn, V, Rahul, P, Ramos, T, Rankin, A, Ratnayake, P, Reuto-Castillo, J, Ridolfo, A, Rios-Valencia, J, Riss, P, Rival, E, Rivillas, J, Roi, D, Rollo, EM, Romanchishen, A, Romito, M, Rotnagl, J, Rovcanin, B, Russo, G, Sabol, M, Saki, S, Saleh, S, Salih, A, Saltiki, A, Salvador-Camarmo, G, Samal, DK, Sánchez-Flores, S, Sapalidis, K, Sarin, D, Sarin, H, Savkovic, N, Scheffel, RS, Scheinpflug, AL, Scheuba, C, Scheyer, N, Schmidt, M, Senashova, O, Serafini, E, Serrano Arévalo, ML, Shank, J, Shindo, ML, Shoshkova, M, Shvan, M, Sičák, M, Silva, TG, Simó Guerrero, O, Skuletic, V, Slijepcevic, N, Slovic, Z, Soares, P, Somova, A, Soto, S, Spiezia, S, Stankovic, V, Stephenson, KJ, Straub, E, Summa, M, Surani, S, Syed, AA, Symeonidis, S, Taciak, A, Tarallo, M, Tarle, A, Tasis, N, Tausanovic, K, Tchabashvili, L, Thierry, M, Tokarczyk, U, Toma, EA, Topuz, S, Torresan, F, Uras, C, Vaccaro, C, Valdés de Anca, Á, Valentini, M, Varaldo, E, Vartanian, JG, Verras, GI, Vithanage, A, Wijayalathge, H, Wiriyaamornchai, P, Wong, YLC, Wongwattana, P, Xenaki, S, Xie, S, Xu, M, Yang, W, Yilmaz, S, Yılmaz, YF, Yotsov, T, Zahid, MT, Zielke, A, Medas, Fabio, Dobrinja, Chiara, Al-Suhaimi, Ebtesam Abdullah, Altmeier, Julia, Anajar, Said, Arikan, Akif Enes, Azaryan, Irina, Bains, Lovenish, Basili, Giancarlo, Bolukbasi, Hakan, Bononi, Marco, Borumandi, Farzad, Bozan, Mehmet Buğra, Brenta, Gabriela, Brunaud, Laurent, Brunner, Maximilian, Buemi, Antoine, Canu, Gian Luigi, Cappellacci, Federico, Cartwright, Sara Burchfield, Castells Fusté, Ignasi, Cavalheiro, Beatriz, Cavallaro, Giuseppe, Chala, Andres, Chan, Shun Yan Bryant, Chaplin, John, Cheema, Mustafa Sajjad, Chiapponi, Costanza, Chiofalo, Maria Grazia, Chrysos, Emmanuel, D'Amore, Annamaria, de Cillia, Michael, De Crea, Carmela, de Manzini, Nicolò, de Matos, Leandro Luongo, De Pasquale, Loredana, Del Rio, Paolo, Demarchi, Marco Stefano, Dhiwakar, Muthuswamy, Donatini, Gianluca, Dora, Jose Miguel, D'Orazi, Valerio, Doulatram Gamgaram, Viyey Kishore, Eismontas, Vitalijus, Kabiri, El Hassane, El Malki, Hadj Omar, Elzahaby, Islam, Enciu, Octavian, Eskander, Antoine, Feroci, Francesco, Figueroa-Bohorquez, David, Filis, Dimitrios, Gorostidi, François, Frías-Fernández, Pedro, Gamboa-Dominguez, Armando, Genc, Volkan, Giordano, Davide, Gómez-Pedraza, Antonio, Graceffa, Giuseppa, Griffin, James, Guerreiro, Sofia Cuco, Gupta, Karan, Gupta, Keshav Kumar, Gurrado, Angela, Hajiioannou, Jiannis, Hakala, Tommi, Harahap, Wirsma Arif, Hargitai, Lindsay, Hartl, Dana, Hellmann, Andrzej, Hlozek, Jiri, Hoang, Van Trung, Iacobone, Maurizio, Innaro, Nadia, Ioannidis, Orestis, Jang, J H Isabelle, Xavier-Junior, Jose Candido, Jovanovic, Milan, Kaderli, Reto Martin, Kakamad, Fahmi, Kaliszewski, Krzysztof, Karamanliev, Martin, Katoh, Hiroshi, Košec, Andro, Kovacevic, Bozidar, Kowalski, Luiz Paulo, Králik, Robert, Yadav, Sanjay Kumar, Kumorová, Adriána, Lampridis, Savvas, Lasithiotakis, Konstantinos, Leclere, Jean-Christophe, Leong, Eugene Kwong Fei, Leow, Melvin Khee-Shing, Lim, James Y, Lino-Silva, Leonardo S, Liu, Shirley Yuk Wah, Llorach, Núria Perucho, Lombardi, Celestino Pio, López-Gómez, Javier, Lori, Eleonora, Quintanilla-Dieck, Lourdes, Lucchini, Roberta, Madani, Amin, Manatakis, Dimitrios, Markovic, Ivan, Materazzi, Gabriele, Mazeh, Haggi, Mercante, Giuseppe, Meyer-Rochow, Goswin Yason, Mihaljevic, Olgica, Miller, Julie A, Minuto, Michele, Monacelli, Massimo, Mulita, Francesk, Mullineris, Barbara, Muñoz-de-Nova, José Luis, Muradás Girardi, Fábio, Nader, Saki, Napadon, Tangjaturonrasme, Nastos, Constantinos, Offi, Chiara, Ronen, Ohad, Oragano, Luigi, Orois, Aida, Pan, Yongqin, Panagiotidis, Emmanouil, Panchangam, Ramakanth Bhargav, Papavramidis, Theodosios, Parida, Pradipta Kumar, Paspala, Anna, Pérez, Òscar Vidal, Petrovic, Sabrina, Raffaelli, Marco, Ramacciotti, Constanza Fernanda, Ratia Gimenez, Tomas, Rivo Vázquez, Ángel, Roh, Jong-Lyel, Rossi, Leonardo, Sanabria, Alvaro, Santeerapharp, Alena, Semenov, Arseny, Seneviratne, Sanjeewa, Serdar, Altinay, Sheahan, Patrick, Sheppard, Sean C, Slotcavage, Rachel L, Smaxwil, Constantin, Kim, Soo Young, Sorrenti, Salvatore, Spartalis, Eleftherios, Sriphrapradang, Chutintorn, Testini, Mario, Turk, Yigit, Tzikos, George, Vabalayte, Kristina, Vargas-Osorio, Kelly, Vázquez Rentería, Rafael Sebastián, Velázquez-Fernández, David, Vithana, Sanura Malinda Pallegoda, Yücel, Levent, Yulian, Erwin Danil, Zahradnikova, Petra, Zarogoulidis, Paul, Ziablitskaia, Evgeniia, Zolotoukho, Anna, and Calò, Pietro Giorgio

Published
2023
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6. Integration of RNTuple in ATLAS Athena

Author

de Geus Florine, López-Gómez Javier, Blomer Jakob, Nowak Marcin, and van Gemmeren Peter

Subjects
Physics, QC1-999
Abstract

After using ROOT’s TTree I/O subsystem for over two decades and storing more than an exabyte of compressed High Energy Physics (HEP) data, advances in technology have motivated a complete redesign, RNTuple, which breaks backward-compatibility to take better advantage of these storage options. The RNTuple I/O subsystem has been designed to address performance bottlenecks and other shortcomings of TTree. Specifically, RNTuple comes with an updated, more compact binary data format that can be stored both in ROOT files and natively in object stores. It is designed for modern storage hardware (e.g. high-throughput low-latency NVMe SSDs), and provides robust and easy to use interfaces. The binary format of RNTuple is scheduled to become production grade in 2024, and recently has become mature enough to start exploring the integration into software used by HEP experiments. In this contribution, we discuss the developments to support the features as required by the ATLAS analysis Event Data Model (EDM) in RNTuple, which will enable its integration into the Athena software framework. With these developments in place, we evaluate the performance of the current most recent versions of RNTuple-based ATLAS data sets and compare this to that of TTree.

Published
2024
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12. Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Author

Medas, Fabio, primary, Dobrinja, Chiara, additional, Al-Suhaimi, Ebtesam Abdullah, additional, Altmeier, Julia, additional, Anajar, Said, additional, Arikan, Akif Enes, additional, Azaryan, Irina, additional, Bains, Lovenish, additional, Basili, Giancarlo, additional, Bolukbasi, Hakan, additional, Bononi, Marco, additional, Borumandi, Farzad, additional, Bozan, Mehmet Buğra, additional, Brenta, Gabriela, additional, Brunaud, Laurent, additional, Brunner, Maximilian, additional, Buemi, Antoine, additional, Canu, Gian Luigi, additional, Cappellacci, Federico, additional, Cartwright, Sara Burchfield, additional, Castells Fusté, Ignasi, additional, Cavalheiro, Beatriz, additional, Cavallaro, Giuseppe, additional, Chala, Andres, additional, Chan, Shun Yan Bryant, additional, Chaplin, John, additional, Cheema, Mustafa Sajjad, additional, Chiapponi, Costanza, additional, Chiofalo, Maria Grazia, additional, Chrysos, Emmanuel, additional, D'Amore, Annamaria, additional, de Cillia, Michael, additional, De Crea, Carmela, additional, de Manzini, Nicolò, additional, de Matos, Leandro Luongo, additional, De Pasquale, Loredana, additional, Del Rio, Paolo, additional, Demarchi, Marco Stefano, additional, Dhiwakar, Muthuswamy, additional, Donatini, Gianluca, additional, Dora, Jose Miguel, additional, D'Orazi, Valerio, additional, Doulatram Gamgaram, Viyey Kishore, additional, Eismontas, Vitalijus, additional, Kabiri, El Hassane, additional, El Malki, Hadj Omar, additional, Elzahaby, Islam, additional, Enciu, Octavian, additional, Eskander, Antoine, additional, Feroci, Francesco, additional, Figueroa-Bohorquez, David, additional, Filis, Dimitrios, additional, Gorostidi, François, additional, Frías-Fernández, Pedro, additional, Gamboa-Dominguez, Armando, additional, Genc, Volkan, additional, Giordano, Davide, additional, Gómez-Pedraza, Antonio, additional, Graceffa, Giuseppa, additional, Griffin, James, additional, Guerreiro, Sofia Cuco, additional, Gupta, Karan, additional, Gupta, Keshav Kumar, additional, Gurrado, Angela, additional, Hajiioannou, Jiannis, additional, Hakala, Tommi, additional, Harahap, Wirsma Arif, additional, Hargitai, Lindsay, additional, Hartl, Dana, additional, Hellmann, Andrzej, additional, Hlozek, Jiri, additional, Hoang, Van Trung, additional, Iacobone, Maurizio, additional, Innaro, Nadia, additional, Ioannidis, Orestis, additional, Jang, J H Isabelle, additional, Xavier-Junior, Jose Candido, additional, Jovanovic, Milan, additional, Kaderli, Reto Martin, additional, Kakamad, Fahmi, additional, Kaliszewski, Krzysztof, additional, Karamanliev, Martin, additional, Katoh, Hiroshi, additional, Košec, Andro, additional, Kovacevic, Bozidar, additional, Kowalski, Luiz Paulo, additional, Králik, Robert, additional, Yadav, Sanjay Kumar, additional, Kumorová, Adriána, additional, Lampridis, Savvas, additional, Lasithiotakis, Konstantinos, additional, Leclere, Jean-Christophe, additional, Leong, Eugene Kwong Fei, additional, Leow, Melvin Khee-Shing, additional, Lim, James Y, additional, Lino-Silva, Leonardo S, additional, Liu, Shirley Yuk Wah, additional, Llorach, Núria Perucho, additional, Lombardi, Celestino Pio, additional, López-Gómez, Javier, additional, Lori, Eleonora, additional, Quintanilla-Dieck, Lourdes, additional, Lucchini, Roberta, additional, Madani, Amin, additional, Manatakis, Dimitrios, additional, Markovic, Ivan, additional, Materazzi, Gabriele, additional, Mazeh, Haggi, additional, Mercante, Giuseppe, additional, Meyer-Rochow, Goswin Yason, additional, Mihaljevic, Olgica, additional, Miller, Julie A, additional, Minuto, Michele, additional, Monacelli, Massimo, additional, Mulita, Francesk, additional, Mullineris, Barbara, additional, Muñoz-de-Nova, José Luis, additional, Muradás Girardi, Fábio, additional, Nader, Saki, additional, Napadon, Tangjaturonrasme, additional, Nastos, Constantinos, additional, Offi, Chiara, additional, Ronen, Ohad, additional, Oragano, Luigi, additional, Orois, Aida, additional, Pan, Yongqin, additional, Panagiotidis, Emmanouil, additional, Panchangam, Ramakanth Bhargav, additional, Papavramidis, Theodosios, additional, Parida, Pradipta Kumar, additional, Paspala, Anna, additional, Pérez, Òscar Vidal, additional, Petrovic, Sabrina, additional, Raffaelli, Marco, additional, Ramacciotti, Constanza Fernanda, additional, Ratia Gimenez, Tomas, additional, Rivo Vázquez, Ángel, additional, Roh, Jong-Lyel, additional, Rossi, Leonardo, additional, Sanabria, Alvaro, additional, Santeerapharp, Alena, additional, Semenov, Arseny, additional, Seneviratne, Sanjeewa, additional, Serdar, Altinay, additional, Sheahan, Patrick, additional, Sheppard, Sean C, additional, Slotcavage, Rachel L, additional, Smaxwil, Constantin, additional, Kim, Soo Young, additional, Sorrenti, Salvatore, additional, Spartalis, Eleftherios, additional, Sriphrapradang, Chutintorn, additional, Testini, Mario, additional, Turk, Yigit, additional, Tzikos, George, additional, Vabalayte, Kristina, additional, Vargas-Osorio, Kelly, additional, Vázquez Rentería, Rafael Sebastián, additional, Velázquez-Fernández, David, additional, Vithana, Sanura Malinda Pallegoda, additional, Yücel, Levent, additional, Yulian, Erwin Danil, additional, Zahradnikova, Petra, additional, Zarogoulidis, Paul, additional, Ziablitskaia, Evgeniia, additional, Zolotoukho, Anna, additional, Calò, Pietro Giorgio, additional, Abdallah, A, additional, Abentroth, AL, additional, Acheimastos, V, additional, Agunaoun, M, additional, Al Bisher, HM, additional, Al Ghuzlan, A, additional, Alakus, H, additional, Alkan, M, additional, Almaraz Almaraz, MC, additional, Amram, K, additional, Anesidis, S, additional, Anestiadou, E, additional, Angelucci, D, additional, Ansaldo, GL, additional, Antonopoulou, MI, additional, Arciniegas, M, additional, Armellin, C, additional, Arredondo Saldaña, G, additional, Astl, J, additional, Athanasakis, E, additional, Avenia, S, additional, Aydın, H, additional, Baba, B, additional, Babala, J, additional, Banús, MV, additional, Barba-Valadez, LA, additional, Barcons, SV, additional, Battafarano, F, additional, Bayat, A, additional, Bella, RMC, additional, Benariba, F, additional, Bernardi, S, additional, Bignami, EG, additional, Bitenc, M, additional, Bitsianis, S, additional, Bolaños de la Torre, JDD, additional, Bonati, E, additional, Bonetti, T, additional, Borges, FA, additional, Bouchagier, K, additional, Boudina, M, additional, Bourial, A, additional, Breuskin, I, additional, Brock, P, additional, Bruns, C, additional, Burlacu, MC, additional, Burton, T, additional, Buta, M, additional, Buzanakov, D, additional, Caliseo, C, additional, Callanan, D, additional, Calu, V, additional, Cameselle-Teijeiro, JM, additional, Camilo-Junior, DJ, additional, Canberk, S, additional, Candalise, V, additional, Candanedo-Gonzalez, F, additional, Carrillo Lizarazo, LJ, additional, Carvalho, GB, additional, Casallas, D, additional, Casolino, C, additional, Castellani, L, additional, Castillo Morales, C, additional, Chambon, G, additional, Chatzipavlidou, V, additional, Chernikov, R, additional, Chorti, A, additional, Chow, TCM, additional, Chrisoulidou, A, additional, Chrysos, E, additional, Conrado-Neto, S, additional, Cordova García, D, additional, Corigliano, A, additional, Crocco, A, additional, Cuesta, A, additional, Čukman, M, additional, Curto, LS, additional, Damilano, RA, additional, D'Anna, R, additional, De, M, additional, De Virgilio, A, additional, Dellaportas, D, additional, Demarquet, L, additional, Devresse, A, additional, Di Meo, G, additional, Diaz Pedrero, R, additional, Dimitrov, D, additional, Dmitry, Z, additional, Domínguez Garijo, P, additional, Dulgeroglu, O, additional, Dural, AC, additional, Eksi, A, additional, El Hammoumi, M, additional, El Kaoui, H, additional, Eleni, G, additional, Elliyanti, A, additional, Ersöz, Ş, additional, Escobar-Jiménez, M, additional, Fedorova, L, additional, Feeley, L, additional, Fernández Rodríguez, E, additional, Ferreli, F, additional, Filoia, A, additional, Fingeret, A, additional, Francescato, A, additional, Gaino, F, additional, Galiandro, F, additional, Gallegos-Hernández, JF, additional, Garas, G, additional, García Lorenzo, F, additional, García-Chávez, JP, additional, Gaudiello, M, additional, Gay, S, additional, Gerasimos, S, additional, Gerek, M, additional, Gervasi, R, additional, Giordano, A, additional, Gjeloshi, B, additional, Gocký, L, additional, Golubinskaya, E, additional, González Romero, S, additional, González-Mínguez, C, additional, Goran, M, additional, Gosman, A, additional, Granados Garcia, M, additional, Greco, E, additional, Grünbart, M, additional, Grützmann, R, additional, Guerlain, J, additional, Guirao, XG, additional, Guzey, D, additional, Hajjij, A, additional, Hamdy, O, additional, Hameed, MS, additional, Hauth, LA, additional, Hernández-Acevedo, JD, additional, Hernandez-Carrillo, JF, additional, Hevilla Sánchez, F, additional, Hoi, H, additional, Hongkwon, K, additional, Hu Zhu, R, additional, Huang, E, additional, Hyeung Kyoo, K, additional, Ignjatovic, V, additional, Ioannidis, A, additional, Iossa, A, additional, Işık, A, additional, James, D, additional, Jung Hoon, L, additional, Kara, H, additional, Karajovic, J, additional, Kartini, D, additional, Khambri, D, additional, Kholová, I, additional, Kisiel, M, additional, Knežević, M, additional, Koh, YQ, additional, Konca, C, additional, Kosmidis, C, additional, Kotsovolis, G, additional, Kowalski, LP, additional, Kralik, R, additional, Kuczma, P, additional, Kuravi, BG, additional, Kurnia, A, additional, Kyriaki, V, additional, Lai, CM, additional, Lallemant, B, additional, Lardhi, AA, additional, Leboulleux, S, additional, Lee, JW, additional, Lelli, G, additional, Leutner, M, additional, Lim, MY, additional, Lim, CM, additional, Llanos, A, additional, Lo, X, additional, Loderer, T, additional, López-Corrales, MA, additional, Ludwig, M, additional, Magnabosco, FF, additional, Maheo, C, additional, Maia, AL, additional, Makay, O, additional, Maksimova, P, additional, Mallick, S, additional, Mallouk, C, additional, Mamani, Z, additional, Mandal, S, additional, Manyalich Blasi, M, additional, Marincola, G, additional, Marulanda, M, additional, Mavromati, M, additional, Mayilvaganan, S, additional, Metso, S, additional, Micalizzi, A, additional, Michalopoulos, A, additional, Min-Su, K, additional, Miron, A, additional, Mishra, AK, additional, Misso, C, additional, Mittermair, C, additional, Morosán Allo, Y, additional, Mourad, M, additional, Moysidis, M, additional, Nabhan, F, additional, Nasiri, R, additional, Nastos, C, additional, Ngiam, KY, additional, Nomine-Criqui, C, additional, Ntziovara, AM, additional, Nuño Vázquez-Garza, JM, additional, Nutautiene, V, additional, Obtulovičová, K, additional, O'Keeffe, L, additional, Okudur, NO, additional, Ossola, P, additional, Ovejero Merino, E, additional, Ozdemir, M, additional, Pangonis, A, additional, Panigoro, SS, additional, Panuzi, A, additional, Papaconstantinou, D, additional, Pardo Matamoros, N, additional, Paschou, S, additional, Pasculli, A, additional, Paterakis, K, additional, Peiris, K, additional, Pennestrì, F, additional, Peppa, M, additional, Perdikaris, P, additional, Perdikaris, I, additional, Pérez-Soto, RH, additional, Piana, S, additional, Piccoli, M, additional, Pietrasanta, D, additional, Placentino, G, additional, Pliakos, I, additional, Polistena, A, additional, Pongtippan, A, additional, Potard, G, additional, Quinn, V, additional, Rahul, P, additional, Ramos, T, additional, Rankin, A, additional, Ratnayake, P, additional, Reuto-Castillo, J, additional, Ridolfo, A, additional, Rios-Valencia, J, additional, Riss, P, additional, Rival, E, additional, Rivillas, J, additional, Roi, D, additional, Rollo, EM, additional, Romanchishen, A, additional, Romito, M, additional, Rotnagl, J, additional, Rovcanin, B, additional, Russo, G, additional, Sabol, M, additional, Saki, S, additional, Saleh, S, additional, Salih, A, additional, Saltiki, A, additional, Salvador-Camarmo, G, additional, Samal, DK, additional, Sánchez-Flores, S, additional, Sapalidis, K, additional, Sarin, D, additional, Sarin, H, additional, Savkovic, N, additional, Scheffel, RS, additional, Scheinpflug, AL, additional, Scheuba, C, additional, Scheyer, N, additional, Schmidt, M, additional, Senashova, O, additional, Serafini, E, additional, Serrano Arévalo, ML, additional, Shank, J, additional, Shindo, ML, additional, Shoshkova, M, additional, Shvan, M, additional, Sičák, M, additional, Silva, TG, additional, Simó Guerrero, O, additional, Skuletic, V, additional, Slijepcevic, N, additional, Slovic, Z, additional, Soares, P, additional, Somova, A, additional, Soto, S, additional, Spiezia, S, additional, Stankovic, V, additional, Stephenson, KJ, additional, Straub, E, additional, Summa, M, additional, Surani, S, additional, Syed, AA, additional, Symeonidis, S, additional, Taciak, A, additional, Tarallo, M, additional, Tarle, A, additional, Tasis, N, additional, Tausanovic, K, additional, Tchabashvili, L, additional, Thierry, M, additional, Tokarczyk, U, additional, Toma, EA, additional, Topuz, S, additional, Torresan, F, additional, Uras, C, additional, Vaccaro, C, additional, Valdés de Anca, Á, additional, Valentini, M, additional, Varaldo, E, additional, Vartanian, JG, additional, Verras, GI, additional, Vithanage, A, additional, Wijayalathge, H, additional, Wiriyaamornchai, P, additional, Wong, YLC, additional, Wongwattana, P, additional, Xenaki, S, additional, Xie, S, additional, Xu, M, additional, Yang, W, additional, Yilmaz, S, additional, Yılmaz, YF, additional, Yotsov, T, additional, Zahid, MT, additional, and Zielke, A, additional

Published
2023
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14. Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Author

Medas, Fabio, Dobrinja, Chiara, Al-Suhaimi, Ebtesam Abdullah, Altmeier, Julia, Anajar, Said, Arikan, Akif Enes, Azaryan, Irina, Bains, Lovenish, Basili, Giancarlo, Bolukbasi, Hakan, Bononi, Marco, Borumandi, Farzad, Bozan, Mehmet Buğra, Brenta, Gabriela, Brunaud, Laurent, Brunner, Maximilian, Buemi, Antoine, Canu, Gian Luigi, Cappellacci, Federico, Cartwright, Sara Burchfield, Castells Fusté, Ignasi, Cavalheiro, Beatriz, Cavallaro, Giuseppe, Chala, Andres, Chan, Shun Yan Bryant, Chaplin, John, Cheema, Mustafa Sajjad, Chiapponi, Costanza, Chiofalo, Maria Grazia, Chrysos, Emmanuel, D'Amore, Annamaria, de Cillia, Michael, De Crea, Carmela, de Manzini, Nicolò, de Matos, Leandro Luongo, De Pasquale, Loredana, Del Rio, Paolo, Demarchi, Marco Stefano, Dhiwakar, Muthuswamy, Donatini, Gianluca, Dora, Jose Miguel, D'Orazi, Valerio, Doulatram Gamgaram, Viyey Kishore, Eismontas, Vitalijus, Kabiri, El Hassane, El Malki, Hadj Omar, Elzahaby, Islam, Enciu, Octavian, Eskander, Antoine, Feroci, Francesco, Figueroa-Bohorquez, David, Filis, Dimitrios, François, Gorostidi, Frías-Fernández, Pedro, Gamboa-Dominguez, Armando, Genc, Volkan, Giordano, Davide, Gómez-Pedraza, Antonio, Graceffa, Giuseppa, Griffin, James, Guerreiro, Sofia Cuco, Gupta, Karan, Gupta, Keshav Kumar, Gurrado, Angela, Hajiioannou, Jiannis, Hakala, Tommi, Harahap, Wirsma Arif, Hargitai, Lindsay, Hartl, Dana, Hellmann, Andrzej, Hlozek, Jiri, Hoang, Van Trung, Iacobone, Maurizio, Innaro, Nadia, Ioannidis, Orestis, Jang, J H Isabelle, Xavier-Junior, Jose Candido, Jovanovic, Milan, Kaderli, Reto Martin, Kakamad, Fahmi, Kaliszewski, Krzysztof, Karamanliev, Martin, Katoh, Hiroshi, Košec, Andro, Kovacevic, Bozidar, Kowalski, Luiz Paulo, Králik, Robert, Yadav, Sanjay Kumar, Kumorová, Adriána, Lampridis, Savvas, Lasithiotakis, Konstantinos, Leclere, Jean-Christophe, Leong, Eugene Kwong Fei, Leow, Melvin Khee-Shing, Lim, James Y, Lino-Silva, Leonardo S, Liu, Shirley Yuk Wah, Llorach, Núria Perucho, Lombardi, Celestino Pio, López-Gómez, Javier, Lori, Eleonora, Quintanilla-Dieck, Lourdes, Lucchini, Roberta, Madani, Amin, Manatakis, Dimitrios, Markovic, Ivan, Materazzi, Gabriele, Mazeh, Haggi, Mercante, Giuseppe, Meyer-Rochow, Goswin Yason, Mihaljevic, Olgica, Miller, Julie A, Minuto, Michele, Monacelli, Massimo, Mulita, Francesk, Mullineris, Barbara, Muñoz-de-Nova, José Luis, Muradás Girardi, Fábio, Nader, Saki, Napadon, Tangjaturonrasme, Nastos, Constantinos, Offi, Chiara, Ronen, Ohad, Oragano, Luigi, Orois, Aida, Pan, Yongqin, Panagiotidis, Emmanouil, Panchangam, Ramakanth Bhargav, Papavramidis, Theodosios, Parida, Pradipta Kumar, Paspala, Anna, Pérez, Òscar Vidal, Petrovic, Sabrina, Raffaelli, Marco, Ramacciotti, Constanza Fernanda, Ratia Gimenez, Tomas, Rivo Vázquez, Ángel, Roh, Jong-Lyel, Rossi, Leonardo, Sanabria, Alvaro, Santeerapharp, Alena, Semenov, Arseny, Seneviratne, Sanjeewa, Serdar, Altinay, Sheahan, Patrick, Sheppard, Sean C, Slotcavage, Rachel L, Smaxwil, Constantin, Kim, Soo Young, Sorrenti, Salvatore, Spartalis, Eleftherios, Sriphrapradang, Chutintorn, Testini, Mario, Turk, Yigit, Tzikos, George, Vabalayte, Kristina, Vargas-Osorio, Kelly, Vázquez Rentería, Rafael Sebastián, Velázquez-Fernández, David, Vithana, Sanura Malinda Pallegoda, Yücel, Levent, Yulian, Erwin Danil, Zahradnikova, Petra, Zarogoulidis, Paul, Ziablitskaia, Evgeniia, Zolotoukho, Anna, and Calò, Pietro Giorgio

Subjects
610 Medicine & health
Abstract

BACKGROUND Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. METHODS In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. FINDINGS Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p

Published
2023
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25. Estudio de detección de faltas en transformadores rectificadores de 12 pulsos de aeronaves

Author

López Gómez, Javier Alexander, Universitat Politècnica de Catalunya. Departament d'Enginyeria Elèctrica, Saura Perisé, Jaime, and Bogarra Rodríguez, Santiago

Subjects
Transformadors elèctrics, Enginyeria elèctrica::Maquinària i aparells elèctrics::Transformadors elèctrics [Àrees temàtiques de la UPC], Aeronàutica i espai::Mecànica de vol [Àrees temàtiques de la UPC], Electric transformers, Application software, Airplanes--Electric equipment, Electric current rectifiers, Programari d'aplicació, Rectificadors de corrent elèctric, Aeronaus -- Equip elèctric
Published
2019

30. Laryngeal chondrosarcoma, case report and literature review

Author

Hernández-Brito, Carlos, primary, Salazar-Álvarez, María Alejandra, additional, Álvarez-Bojórquez, Mario Enrique, additional, Cisneros-Juvera, Francisco Carlos, additional, López-Gómez, Javier, additional, Elizalde-Méndez, Ángel, additional, and Granados-García, Martín, additional

Published
2018
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31. Treatment of intimal sarcoma of peripheral veins

Author

López-Gómez, Javier, primary, Flores-Vázquez, Erwin R., additional, Salazar-Álvarez, Ma. Alejandra, additional, Adame, Rodrigo Y., additional, Garcia-Ortega, Dorian Y., additional, and Cuellar-Hübbe, Mario, additional

Published
2017
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32. Análise preliminar para viabilidade de incorporação de incentivos econômicos para a conservação e uso de recursos hídricos na Bacia Média - Alta do Rio Fragua Chorroso, Amazônia Colombiana

Author

López Gómez, Javier Enrique and Vieira, Gil

Subjects
Conservação, Recursos hídricos, Incentivos econômicos
Abstract

As áreas do Sistema Nacional de Áreas Protegidas (SINAP) são de grande importância estratégica para o fornecimento dos serviços dos ecossistemas, ao abastecer água de forma direta e indireta para a população colombiana numa porcentagem superior ao 52%. Assim, na bacia média do rio de alta Chorroso Fragua localizada em uma zona de amortecimento do Parque Nacional Natural Indi Wasi, está projetada a construção de um aqueduto regional para fornecer os municípios de San José del Fragua, Albânia e Curillo; não obstante, existem atividades agrícolas que ameaçam a conservação dos recursos hídricos, e ainda não têm-se ferramentas que permitam a abordagem de alternativas de mitigação dos impactos. Dadas estas considerações, a presente pesquisa tenta fazer uma análise para avaliar se a introdução de incentivos econômicos é uma ferramenta para mitigar os impactos a esses ecossistemas. Com esse intuito, foi realizada uma análise preliminar da viabilidade econômica da incorporação de um sistema de compensação por serviços ambientais, que permitam a alteração ou melhoria das atividades agrícolas e pecuárias que impactam negativamente a bacia média e alta do Rio Fragua Chorroso. Foi feita uma análise de custo/benefício para as atividades de produção, na qual foram realizados questionários em 35 produtores de gado e 24 produtores de cana. Verificou-se que ambas as atividades são insustentáveis do ponto de vista financeiro e ambiental, e que o custo de oportunidade para a atividade do gado é muito maior do que para o cultivo da cana. Da mesma forma, é evidente que a mudança no uso da terra é baixa, o que é visto como uma oportunidade para implementar um sistema de compensação por serviços ambientais (CSE) , que deve adotar estes valores como referência. The areas of the Protected Areas National System (SINAP) are of great strategic importance for the supply of ecosystem services, for the supply of water directly and indirectly to the Colombian population, in a superior percentage than 52%. Thus, in the average high - Chorroso Fragua river basin, located in a buffer zone of Natural Indi Wasi National Park, it`s being projected the construction of a regional pipeline to supply the municipalities of San Jose del Fragua, Albania and Curillo; however, there are agricultural activities that threaten the conservation of water resources, and still doesn`t exist the tools that allow the approach of impact`s alternative mitigation. Given these considerations, this research tries to make an analysis to assess if the introduction of economic incentives is a tool that allows to mitigate the impacts produced to these ecosystems. With that objective, it was made a preliminary analysis of the economic viability in incorporating a compensation scheme for ecosystem services, that enable the change or improvement of agricultural and livestock activities that negatively affect the middle and upper basin of the Fragua Chorroso river. It was developed a benefit/cost analysis for production activities, for which surveys were conducted at 35 livestock producers and 24 cane producers. It was found that both activities are unsustainable from a financial and environmental point of view, and that the opportunity cost for livestock is much higher than for sugarcane cultivation. Likewise, it is evident that the change in land use is low, situation that can be seen as an opportunity to implement a compensation scheme for Ecosystem Services (CSE), which must take these values as a reference.

Published
2015

33. fsniff: análisis, diseño e implementación de una suite software para captura y análisis de E/S

Author

López Gómez, Javier, Calderón Mateos, Alejandro, Fernández Muñoz, Javier, and Universidad Carlos III de Madrid. Departamento de Informática

Subjects
Informática, Desarrollo Kernel, Ingeniería inversa, Linux (Sistema operativo), Reverse engineering, Kernel development
Abstract

Este proyecto final de carrera ha consistido en la implementación de una suite software para la traza y análisis de acceso a ficheros en el sistema operativo GNU/Linux. Éste incluye un mecanismo de traza de bajo overhead basado en un módulo de kernel que parchea el kernel Linux que está corriendo. Por tanto, no se requiere recompilación del núcleo ni soporte de instrumentación (Ftrace/Kprobe). Para el análisis de log, se proveen varias herramientas que permiten extraer streams o la visualización de un grafo de accesos en tiempo real. Con todo esto se pretende que este proyecto sea de interés para la ingeniería inversa y el perfilaje (puede ser usado para optimizar programas que generan un carga E/S pesada). This thesis consisted in the implementation of a software suite for file access tracing and analysis on the GNU/Linux operating system. It includes a low-overhead trace mechanism based on a kernel module that patches the running Linux kernel. Thus, no kernel recompilation nor instrumentation support (Ftrace/Kprobe) is required. On the log analysis side, several tools that allow stream extraction and real-time access graph visualization are provided. It is intented that this project might be of interest for reverse engineering and profiling (may be used to optimize programs that generate heavy I/O load). Ingeniería Técnica en Informática de Gestión

Published
2015

34. Proyecto estructural de un edificio residencial en hormigón armado

Author

López Gómez, Javier

Subjects
INGENIERIA DE LA CONSTRUCCION, Construcciones de hormigón armado, Consulta en la Biblioteca ETSI Industriales, Ingeniero Industrial-Enginyer Industrial
Abstract

Consulta en la Biblioteca ETSI Industriales (7818)

Published
2013

37. Manejo de las urgencias quirúrgicas gastrointestinales en el paciente oncológico.

Author

LÓPEZ-GÓMEZ, JAVIER, LEÓN-TAKAHASHI, ALBERTO MITSUO, and LÓPEZ-BASAVE, HORACIO N.

Subjects
*BOWEL obstructions, *ENTEROCOLITIS, *CANCER patients, *ENTERITIS
Abstract

Introduction: The oncologic patient has particular characteristics that cause the gastrointestinal surgical urgencies to present with a different clinical presentation, and for its management several characteristics must be considered; however, available information is scarce. Objective: To perform algorithms for the treatment of cancer patients who present with gastrointestinal urgencies. Material and method: A systematic search was made in the literature in PubMed, Cochrane, ESMO Clinical Practice Guideline, NICE Guidelines y TripDatabase with the terms MESH "oncological urgencies", "acute malignant bowel obstruction", "radiation enteritis" and "neutropenic enterocolitis". Results: Management algorithms were generated for each situation based on the history and oncological characteristics of the patient and the surgical management already established for non-cancer patients. Discussion: Given the specific characteristics of the oncologic patient and the high incidence of gastrointestinal complications, it is of vital importance to generate special algorithms of management for this type of population. Conclusions: Management algorithms are proposed for cancer patients based on functional status, clinical stage, tumor type and location, oncologic plan, response to oncologic treatment, administered treatments and comorbidities. [ABSTRACT FROM AUTHOR]

Published
2018

38. Supervivencia y periodo libre de enfermedad en premenopáusicas receptores hormonales positivos con cáncer de mama: comparación de exemestano más supresión ovárica versus tamoxifeno.

Author

LÓPEZ-GÓMEZ, JAVIER and ALEJANDRA SALAZAR-ÁLVAREZ, MARÍA

Abstract

Introduction: Adjuvant treatment based on hormone therapy in patients with hormone receptors prolongs survival and free-disease progression. Standard treatment for premenopausal women has been tamoxifen, but there is data claiming exemestane plus ovarian suppression is superior to tamoxifen. Material and Methods: A revision of the literature was carried out using exemestane and breast cancer as MeSH descriptors in browsers with levels of evidence used in clinical practice guidelines. Systematic revisions and randomized clinical trials were searched in browsers like PubMed, Cochrane, ESMO Clinical Practice Guideline, NICE Guidelines, and Tripdatabase. Thirteen articles met the inclusion criteria. Results: Patients who received exemestane had better outcomes in terms of survival at five years (91.1 vs 87.3%), disease-free interval (DFI) (92.8 vs 88.8%), and distant free-recurrence interval (93.8 vs 92%). Absolute benefit in DFI was 1.8%. The highest benefit may be present in women younger than 35 years since DFI between tamoxifen and exemestane was 4.5%. Discussion: An aromatase inhibitor plus ovarian suppression is the treatment of choice for premenopausal patients with hormone receptor-positive breast cancer. DFI at 5 years is 85.7% vs 82.5% with an absolute benefit of 1.8% with exemestane. Conclusions: Exemestane plus ovarian suppression has demonstrated superiority in DFI, as well as in survival, compared with tamoxifen plus ovarian suppression and tamoxifen alone, above all in patients younger than 35 years. [ABSTRACT FROM AUTHOR]

Published
2018

39. Herramienta para el diseño de convertidores cc-cc : forward y flyback

Author

López Gómez, Javier, Fernández Herrero, Cristina, Sanz García, Clara Marina, and Universidad Carlos III de Madrid. Departamento de Tecnología Electrónica

Subjects
Herramientas de software, Electrónica de potencia, Convertidores de potencia, Electrónica
Abstract

Este proyecto fin de carrera consiste en el desarrollo y funcionamiento de una herramienta de diseño de convertidores CC-CC. Realizada en entorno Microsoft Excel es una herramienta de fácil manejo para el usuario. Con un amplio catálogo de componentes esta herramienta permite obtener las mejores configuraciones posibles, en topología forward o flyback, a partir de determinadas especificaciones de diseño. Esta herramienta proporciona información sobre todos los componentes necesarios para el convertidor incluido el transformador que proporciona el aislamiento galvánico. Esta información incluye los datos más relevantes del catálogo así como los valores de las magnitudes más representativas en el funcionamiento del convertidor. La herramienta permite al diseñador hacer todas las configuraciones que desee, guardar los resultados de las mismas en nuevos libros Excel para poder compararlas con otras distintas más adelante e incluso contrastar los resultados con el software de simulación de circuitos electrónicos PSIM. _____________________________________________________________________________________________________________________________ This final project consists of the development and operation of a design tool of DC-DC converters. Made in Microsoft Excel environment is a user friendly tool. With a wide range of components this tool allows to obtain the best possible configurations, in forward or flyback topology, from simple design specifications. This tool provides information of all necessary components for the converter including the transformer which provides galvanic isolation. This information includes the relevant manufacturer datasheet and the values of the most representative magnitudes of the converter performance. The tool allows the designer to do all the necessary settings, to save the results in new Excel workbooks for comparison with others and even to compare the results with the simulation software PSIM. Ingeniería Técnica en Electrónica

Published
2012

45. Definición, desarrollo e implantación de una plataforma empotrada HW/SW para el desarrollo de nanosatélites

Author

Cano Moreno, Adán, López Gómez, Javier, and Universidad Carlos III de Madrid. Departamento de Informática

Subjects
Informática, Nanosatélites, Tecnología espacial, Hardware in the loop, Software in the loop, Sistema operativo de tiempo real, Sistemas empotrados
Abstract

La tecnología espacial está en continua mejora. En los últimos años ha surgido la filosofía New Space que se basa en la colonización del espacio a través de pequeños satélites, que son más baratos y rápidos de fabricar en comparación a los satélites clásicos. Cada vez son más los servicios que son prestados al mundo que necesitan una infraestructura espacial. Además, cada vez son más las empresas que colaboran con universidades para el desarrollo de satélites para el estudio de fenómenos espaciales y el análisis del comportamiento de las nuevas tecnologías en entornos hostiles. Este proyecto pertenece a la cátedra UC3M-SENER, una colaboración entre la Universidad Carlos III de Madrid y una empresa española del sector de la ingeniería, SENER. El objetivo de esta cátedra multidisciplinar es que estudiantes de diferentes departamentos construyan un nanosatélite con la colaboración de SENER. Este proyecto se encarga de la definición del entorno de desarrollo del software y de la integración del software del ordenador de a bordo en un sistema empotrado. El desarrollo del sistema empotrado es fundamental, pues será el encargado de ejecutar el software de a bordo. En el proyecto el sistema empotrado se desarrolla en una BeagleBoard-XM de ARM. El software de a bordo es ejecutado sobre un sistema operativo de tiempo real RTEMS. Para verificar el sistema, se realiza la fase de verificación software-in-the-loop (que prueba el sistema sobre un emulador hardware) y la fase hardware-in-the-loop (que prueba el sistema en el hardware real). Space technology is constantly improving. In recent years, the New Space philosophy has emerged, which is based on the colonization of space through small satellites, which are cheaper and faster to manufacture with respect to classic satellites. Lately, most of the services which are being provided to the world need a space infrastructure. In addition, some companies are collaborating with universities to develop satellites and analyze the behaviour of new technologies in hostile environments. This project belongs to the UC3M-SENER chair, a collaboration between the Carlos III University of Madrid and the Spanish engineering company SENER. The aim of this multidisciplinary chair is for students from different departments to build a nanosatellite in collaboration with SENER. This project is responsible for the definition of the software development environment and the integration of the onboard computer software into an embedded system. The development of the embedded system is fundamental, as it will be in charge of executing the onboard software. For this project, the embedded system is based on an ARM BeagleBoard- XM. The onboard software is executed on a Real Time Operating System. In regards to system verification, we perform software-in-the-loop validation (which tests the system on a hardware emulator), and hardware-in-the-loop validation (which tests the system on the real hardware). Ingeniería Informática

Published
2019

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