43 results on '"López-Madrona, Víctor J."'
Search Results
2. Extracting seizure onset from surface EEG with Independent Component Analysis: insights from simultaneous scalp and intracerebral EEG
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Barborica, Andrei, Mindruta, Ioana, Sheybani, Laurent, Spinelli, Laurent, Oane, Irina, Pistol, Constantin, Donos, Cristian, López-Madrona, Victor J, Vulliemoz, Serge, Bénar, Christian, López-Madrona, Víctor, and Bénar, Christian-George
- Subjects
Quantitative Biology - Neurons and Cognition - Abstract
The success of stereoelectroencephalographic (SEEG) investigations depends crucially on the hypotheses on the putative location of the seizure onset zone. This information is derived from non-invasive data either based on visual analysis or advanced source localization algorithms. While source localization applied to interictal spikes recorded on scalp is the classical method, it does not provide unequivocal information regarding the seizure onset zone. Raw ictal activity contains a mixture of signals originating from several regions of the brain as well as EMG artifacts, hampering direct input to the source localization algorithms. We therefore introduce a methodology that disentangles the various sources contributing to the scalp ictal activity using independent component analysis and uses equivalent current dipole localization as putative locus of ictal sources. We validated the results of our analysis pipeline by performing long-term simultaneous scalp -- intracerebral (SEEG) recordings in 14 patients and analyzing the wavelet coherence between the independent component encoding the ictal discharge and the SEEG signals in 8 patients passing the inclusion criteria. Our results show that invasively recorded ictal onset patterns, including low-voltage fast activity, can be captured by the independent component analysis of scalp EEG. The visibility of the ictal activity strongly depends on the depth of the sources. The equivalent current dipole localization can point to the seizure onset zone (SOZ) with an accuracy that can be as high as 10mm for superficially located sources, that gradually decreases for deeper seizure generators, averaging at 47 mm in the 8 analyzed patients. Independent component analysis is therefore shown to have a promising SOZ localizing value, indicating whether the seizure onset zone is neocortical, and its approximate location, or located in mesial structures. That may contribute to a better crafting of the hypotheses used as basis of the stereo-EEG implantations.
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- 2021
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3. Reconstruction and localization of auditory sources from intracerebral SEEG using independent component analysis
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López-Madrona, Víctor J., Villalon, Samuel Medina, Velmurugan, Jayabal, Semeux-Bernier, Aurore, Garnier, Elodie, Badier, Jean-Michel, Schön, Daniele, and Bénar, Christian-G.
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- 2023
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4. Comparison of beamformer and ICA for dynamic connectivity analysis: A simultaneous MEG-SEEG study
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Coelli, Stefania, Medina Villalon, Samuel, Bonini, Francesca, Velmurugan, Jayabal, López-Madrona, Víctor J., Carron, Romain, Bartolomei, Fabrice, Badier, Jean-Michel, and Bénar, Christian-G.
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- 2023
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5. Inferring correlations associated to causal interactions in brain signals using autoregressive models
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López-Madrona, Víctor J., Matias, Fernanda, Mirasso, Claudio, Canals, Santiago, and Pereda, Ernesto
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Quantitative Biology - Quantitative Methods ,Quantitative Biology - Neurons and Cognition - Abstract
The specific connectivity of a neuronal network is reflected in the dynamics of the signals recorded on its nodes. The analysis of how the activity in one node predicts the behaviour of another gives the directionality in their relationship. However, each node is composed of many different elements which define the properties of the links. For instance, excitatory and inhibitory neuronal subtypes determine the functionality of the connection. Classic indexes such as the Granger causality (GC) quantifies these interactions, but they do not infer into the mechanism behind them. Here, we introduce an extension of the well-known GC that analyses the correlation associated to the specific influence that a transmitter node has over the receiver. This way, the G-causal link has a positive or negative effect if the predicted activity follows directly or inversely, respectively, the dynamics of the sender. The method is validated in a neuronal population model, testing the paradigm that excitatory and inhibitory neurons have a differential effect in the connectivity. Our approach correctly infers the positive or negative coupling produced by different types of neurons. Our results suggest that the proposed approach provides additional information on the characterization of G-causal connections, which is potentially relevant when it comes to understanding interactions in the brain circuits.
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- 2018
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6. Lead/Lag directionality is not generally equivalent to causality in nonlinear systems: Comparison of phase slope index and conditional mutual information
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Arinyo-i-Prats, Andreu, primary, López-Madrona, Víctor J., additional, and Paluš, Milan, additional
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- 2024
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7. Detection and localization of deep sources in magnetoencephalography: A review
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Bénar, Christian-George, Velmurugan, Jayabal, López-Madrona, Victor J., Pizzo, Francesca, and Badier, Jean-Michel
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- 2021
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8. Identification of Early Hippocampal Dynamics during Recognition Memory with Independent Component Analysis.
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López-Madrona, Víctor J., Trébuchon, Agnès, Mindruta, Ioana, Barbeau, Emmanuel J., Barborica, Andrei, Pistol, Costi, Oane, Irina, Alario, F. Xavier, and Bénar, Christian G.
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- 2024
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9. N°141 – Boosting SEEG with independent component analysis: Identification of local and remote neural sources
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López-Madrona, Víctor J., primary, Trébuchon, Agnès, additional, Medina-Villalon, Samuel, additional, Barborica, Andrei, additional, Semeux-Bernier, Aurore, additional, Garnier, Elodie, additional, Schon, Daniele, additional, and Bénar, Christian, additional
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- 2023
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10. Inferring correlations associated to causal interactions in brain signals using autoregressive models
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López-Madrona, Víctor J., Matias, Fernanda S., Mirasso, Claudio R., Canals, Santiago, and Pereda, Ernesto
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- 2019
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11. Studying memory processes at different levels with simultaneous depth and surface EEG recordings
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Barborica, Andrei, primary, Mindruta, Ioana, additional, López-Madrona, Víctor J., additional, Alario, F-Xavier, additional, Trébuchon, Agnès, additional, Donos, Cristian, additional, Oane, Irina, additional, Pistol, Constantin, additional, Mihai, Felicia, additional, and Bénar, Christian G., additional
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- 2023
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12. Site-dependent shaping of field potential waveforms
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Herreras, Óscar, Torres, Daniel, Martín Vazquez, Gonzalo, Hernández Recio, Sara, López Madrona, Víctor J, Benito, Nuria, Makarov, Valeri A., Makarova, Julia, Herreras, Óscar, Torres, Daniel, Martín Vazquez, Gonzalo, Hernández Recio, Sara, López Madrona, Víctor J, Benito, Nuria, Makarov, Valeri A., and Makarova, Julia
- Abstract
The activity of neuron populations gives rise to field potentials (FPs) that extend beyond the sources. Their mixing in the volume dilutes the original temporal motifs in a site-dependent manner, a fact that has received little attention. And yet, it potentially rids of physiological significance the time-frequency parameters of individual waves (amplitude, phase, duration). This is most likely to happen when a single source or a local origin is erroneously assumed. Recent studies using spatial treatment of these signals and anatomically realistic modeling of neuron aggregates provide convincing evidence for the multisource origin and site-dependent blend of FPs. Thus, FPs generated in primary structures like the neocortex and hippocampus reach far and cross-contaminate each other but also, they add and even impose their temporal traits on distant regions. Furthermore, both structures house neurons that act as spatially distinct (but overlapped) FP sources whose activation is state, region, and time dependent,making the composition of so-called local FPs highly volatile and strongly site dependent. Since the spatial reach cannot be predicted without source geometry, it is important to assess whether waveforms and temporalmotifs arise froma single source; otherwise, those from each of the co-active sources should be sought., Ministerio de Ciencia e Innovación (MICINN), Depto. de Análisis Matemático y Matemática Aplicada, Fac. de Ciencias Matemáticas, Instituto de Matemática Interdisciplinar (IMI), TRUE, pub
- Published
- 2023
13. Uncorrelated bilateral cortical input becomes timed across hippocampal subfields for long waves whereas gamma waves are largely ipsilateral
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Ministerio de Ciencia e Innovación (España), Ministerio de Economía, Industria y Competitividad (España), Hernández-Recio, Sara, Muñoz-Arnaiz, Ricardo, López-Madrona, Víctor J., Makarova, Julia, Herreras, Óscar, Ministerio de Ciencia e Innovación (España), Ministerio de Economía, Industria y Competitividad (España), Hernández-Recio, Sara, Muñoz-Arnaiz, Ricardo, López-Madrona, Víctor J., Makarova, Julia, and Herreras, Óscar
- Abstract
The role of interhemispheric connections along successive segments of cortico-hippocampal circuits is poorly understood. We aimed to obtain a global picture of spontaneous transfer of activity during non-theta states across several nodes of the bilateral circuit in anesthetized rats. Spatial discrimination techniques applied to bilateral laminar field potentials (FP) across the CA1/Dentate Gyrus provided simultaneous left and right readouts in five FP generators that reflect activity in specific hippocampal afferents and associative pathways. We used a battery of correlation and coherence analyses to extract complementary aspects at different time scales and frequency bands. FP generators exhibited varying bilateral correlation that was high in CA1 and low in the Dentate Gyrus. The submillisecond delays indicate coordination but not support for synaptic dependence of one side on another. The time and frequency characteristics of bilateral coupling were specific to each generator. The Schaffer generator was strongly bilaterally coherent for both sharp waves and gamma waves, although the latter maintained poor amplitude co-variation. The lacunosum-moleculare generator was composed of up to three spatially overlapping activities, and globally maintained high bilateral coherence for long but not short (gamma) waves. These two CA1 generators showed no ipsilateral relationship in any frequency band. In the Dentate Gyrus, strong bilateral coherence was observed only for input from the medial entorhinal areas, while those from the lateral entorhinal areas were largely asymmetric, for both alpha and gamma waves. Granger causality testing showed strong bidirectional relationships between all homonymous bilateral generators except the lateral entorhinal input and a local generator in the Dentate Gyrus. It also revealed few significant relationships between ipsilateral generators, most notably the anticipation of lateral entorhinal cortex toward all others. Thus, with the notab
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- 2023
14. Identification of an early hippocampal recognition system using intracerebral evoked potentials in humans
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López-Madrona, Víctor J., primary, Trébuchon, Agnès, additional, Mindruta, Ioana, additional, Barbeau, Emmanuel J., additional, Barborica, Andrei, additional, Pistol, Costi, additional, Oane, Irina, additional, Alario, F. Xavier, additional, and Bénar, Christian G., additional
- Published
- 2022
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15. Cover Image
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López‐Madrona, Víctor J., primary, Medina Villalon, Samuel, additional, Badier, Jean‐Michel, additional, Trébuchon, Agnès, additional, Jayabal, Velmurugan, additional, Bartolomei, Fabrice, additional, Carron, Romain, additional, Barborica, Andrei, additional, Vulliémoz, Serge, additional, Alario, F.‐Xavier, additional, and Bénar, Christian G., additional
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- 2022
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16. Site-dependent shaping of field potential waveforms
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Herreras, Oscar, primary, Torres, Daniel, additional, Martín-Vázquez, Gonzalo, additional, Hernández-Recio, Sara, additional, López-Madrona, Víctor J, additional, Benito, Nuria, additional, Makarov, Valeri A, additional, and Makarova, Julia, additional
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- 2022
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17. Magnetoencephalography can reveal deep brain network activities linked to memory processes
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López‐Madrona, Víctor J., primary, Medina Villalon, Samuel, additional, Badier, Jean‐Michel, additional, Trébuchon, Agnès, additional, Jayabal, Velmurugan, additional, Bartolomei, Fabrice, additional, Carron, Romain, additional, Barborica, Andrei, additional, Vulliémoz, Serge, additional, Alario, F.‐Xavier, additional, and Bénar, Christian G., additional
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- 2022
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18. Low-Power Lossless Data Compression for Wireless Brain Electrophysiology
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Cuevas-López, Aarón, primary, Pérez-Montoyo, Elena, additional, López-Madrona, Víctor J., additional, Canals, Santiago, additional, and Moratal, David, additional
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- 2022
- Full Text
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19. Low-power lossless data compression for wireless brain electrophysiology
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Cuevas López, Aarón, Pérez-Montoyo, Elena, López-Madrona, Víctor J., Canals, Santiago, Moratal, David, Cuevas López, Aarón, Pérez-Montoyo, Elena, López-Madrona, Víctor J., Canals, Santiago, and Moratal, David
- Abstract
Wireless electrophysiology opens important possibilities for neuroscience, especially for recording brain activity in more natural contexts, where exploration and interaction are not restricted by the usual tethered devices. The limiting factor is transmission power and, by extension, battery life required for acquiring large amounts of neural electrophysiological data. We present a digital compression algorithm capable of reducing electrophysiological data to less than 65.5% of its original size without distorting the signals, which we tested in vivo in experimental animals. The algorithm is based on a combination of delta compression and Huffman codes with optimizations for neural signals, which allow it to run in small, low-power Field-Programmable Gate Arrays (FPGAs), requiring few hardware resources. With this algorithm, a hardware prototype was created for wireless data transmission using commercially available devices. The power required by the algorithm itself was less than 3 mW, negligible compared to the power saved by reducing the transmission bandwidth requirements. The compression algorithm and its implementation were designed to be device-agnostic. These developments can be used to create a variety of wired and wireless neural electrophysiology acquisition systems with low power and space requirements without the need for complex or expensive specialized hardware.
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- 2022
20. Brain network allostasis after chronic alcohol drinking Is characterized by functional dedifferentiation and narrowing
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European Commission, Academy of Finland, Federal Ministry of Education and Research (Germany), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Generalitat Valenciana, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Ministerio de Educación, Cultura y Deporte (España), German Research Foundation, Pérez-Ramírez, Úrsula, López-Madrona, Víctor J., Pérez-Segura, Andrés, Pallarés, Vicente, Moreno, Andrea, Ciccocioppo, Roberto, Hyytiä, Petri, Sommer, Wolfgang H., Moratal, David, Canals, Santiago, European Commission, Academy of Finland, Federal Ministry of Education and Research (Germany), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Generalitat Valenciana, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Ministerio de Educación, Cultura y Deporte (España), German Research Foundation, Pérez-Ramírez, Úrsula, López-Madrona, Víctor J., Pérez-Segura, Andrés, Pallarés, Vicente, Moreno, Andrea, Ciccocioppo, Roberto, Hyytiä, Petri, Sommer, Wolfgang H., Moratal, David, and Canals, Santiago
- Abstract
Alcohol use disorder (AUD) causes complex alterations in the brain that are poorly understood. The heterogeneity of drinking patterns and the high incidence of comorbid factors compromise mechanistic investigations in AUD patients. Here we used male Marchigian Sardinian alcohol-preferring (msP) rats, a well established animal model of chronic alcohol drinking, and a combination of longitudinal resting-state fMRI and manganese-enhanced MRI to provide objective measurements of brain connectivity and activity, respectively. We found that 1 month of chronic alcohol drinking changed the correlation between resting-state networks. The change was not homogeneous, resulting in the reorganization of pairwise interactions and a shift in the equilibrium of functional connections. We identified two fundamentally different forms of network reorganization. First is functional dedifferentiation, which is defined as a regional increase in neuronal activity and overall correlation, with a concomitant decrease in preferential connectivity between specific networks. Through this mechanism, occipital cortical areas lost their specific interaction with sensory-insular cortex, striatal, and sensorimotor networks. Second is functional narrowing, which is defined as an increase in neuronal activity and preferential connectivity between specific brain networks. Functional narrowing strengthened the interaction between striatal and prefrontocortical networks, involving the anterior insular, cingulate, orbitofrontal, prelimbic, and infralimbic cortices. Importantly, these two types of alterations persisted after alcohol discontinuation, suggesting that dedifferentiation and functional narrowing rendered persistent network states. Our results support the idea that chronic alcohol drinking, albeit at moderate intoxicating levels, induces an allostatic change in the brain functional connectivity that propagates into early abstinence.
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- 2022
21. Site-dependent shaping of field potential waveforms
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Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Herreras, Óscar, Torres, Daniel, Martín-Vázquez, Gonzalo, Hernández-Recio, Sara, López-Madrona, Víctor J., Benito, N., Makarov, V. A., Makarova, Julia, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Herreras, Óscar, Torres, Daniel, Martín-Vázquez, Gonzalo, Hernández-Recio, Sara, López-Madrona, Víctor J., Benito, N., Makarov, V. A., and Makarova, Julia
- Abstract
The activity of neuron populations gives rise to field potentials (FPs) that extend beyond the sources. Their mixing in the volume dilutes the original temporal motifs in a site-dependent manner, a fact that has received little attention. And yet, it potentially rids of physiological significance the time-frequency parameters of individual waves (amplitude, phase, duration). This is most likely to happen when a single source or a local origin is erroneously assumed. Recent studies using spatial treatment of these signals and anatomically realistic modeling of neuron aggregates provide convincing evidence for the multisource origin and site-dependent blend of FPs. Thus, FPs generated in primary structures like the neocortex and hippocampus reach far and cross-contaminate each other but also, they add and even impose their temporal traits on distant regions. Furthermore, both structures house neurons that act as spatially distinct (but overlapped) FP sources whose activation is state, region, and time dependent, making the composition of so-called local FPs highly volatile and strongly site dependent. Since the spatial reach cannot be predicted without source geometry, it is important to assess whether waveforms and temporal motifs arise from a single source; otherwise, those from each of the co-active sources should be sought.
- Published
- 2022
22. Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing
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Pérez-Ramírez, Úrsula, primary, López-Madrona, Víctor J., additional, Pérez-Segura, Andrés, additional, Pallarés, Vicente, additional, Moreno, Andrea, additional, Ciccocioppo, Roberto, additional, Hyytiä, Petri, additional, Sommer, Wolfgang H., additional, Moratal, David, additional, and Canals, Santiago, additional
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- 2022
- Full Text
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23. Magnetoencephalography can reveal deep brain network activities linked to memory processes
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López-Madrona, Víctor J., primary, Villalon, Samuel Medina, additional, Badier, Jean-Michel, additional, Trébuchon, Agnès, additional, Jayabal, Velmurugan, additional, Bartolomei, Fabrice, additional, Carron, Romain, additional, Barborica, Andrei, additional, Vulliémoz, Serge, additional, Alario, F. Xavier, additional, and Bénar, Christian G., additional
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- 2022
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24. Functional Interactions between Entorhinal Cortical Pathways Modulate Theta Activity in the Hippocampus
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López-Madrona, Víctor J., primary and Canals, Santiago, additional
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- 2021
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25. Changes in epileptogenicity biomarkers after stereotactic thermocoagulation
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Contento, Margherita, primary, Pizzo, Francesca, additional, López‐Madrona, Víctor J., additional, Lagarde, Stanislas, additional, Makhalova, Julia, additional, Trébuchon, Agnes, additional, Medina Villalon, Samuel, additional, Giusiano, Bernard, additional, Scavarda, Didier, additional, Carron, Romain, additional, Roehri, Nicolas, additional, Bénar, Christian‐George, additional, and Bartolomei, Fabrice, additional
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- 2021
- Full Text
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26. Studying connectivity between time-series using an interactive application
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Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, López-Madrona, Víctor J., Moratal, David, Bénar, Christian G., Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, López-Madrona, Víctor J., Moratal, David, and Bénar, Christian G.
- Abstract
[Otros] Connectivity is a complex concept whose meaning varies for each domain. In a broad sense, it is possible to divide the connectivity in two main groups: physical and statistical. The former represents whether there is a physical link connecting the elements, like the telephone line, while the latter indicates a relation between the dynamics of the elements, as the number of sales and the income of a company. In several scientific fields, including economics, physics and neuroscience, the statistical connectivity is computed based on the analysis of time-series. Several different methods can be applied on the data, using different features of the signals, like covariance and frequency, to estimate the connectivity, yielding different results and interpretations. The covariance indicates if two elements follow the same dynamics, i.e., if they increase or decrease at the same time. On the other hand, the frequency is related to the time required for the elements to change, which can be daily in the case of the tides, or milliseconds if referred to the computations in a microchip. A third factor is the directionality, with one element depending on the other, but not in the opposite case. This work proposes an interactive computer-based application to generate a three-node network and estimate its connectivity following different approaches. We describe how the application is structured, from the selection of the parameters to the interpretation of the output results, detailing the skills in connectivity that can be developed by the students.
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- 2021
27. Functional interactions between entorhinal cortical pathways modulate theta activity in the hippocampus
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Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Agence Nationale de la Recherche (France), López-Madrona, Víctor J., Canals, Santiago, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Agence Nationale de la Recherche (France), López-Madrona, Víctor J., and Canals, Santiago
- Abstract
Theta oscillations organize neuronal firing in the hippocampus during context exploration and memory formation. Recently, we have shown that multiple theta rhythms coexist in the hippocampus, reflecting the activity in their afferent regions in CA3 (Schaffer collaterals) and the entorhinal cortex layers II (EC-II, perforant pathway) and III (EC-III, temporoammonic pathway). Frequency and phase coupling between theta rhythms were modulated by the behavioral state, with synchronized theta rhythmicity preferentially occurring in tasks involving memory updating. However, information transmission between theta generators was not investigated. Here, we used source separation techniques to disentangle the current generators recorded in the hippocampus of rats exploring a known environment with or without a novel stimulus. We applied analytical tools based on Granger causality and transfer entropy to investigate linear and non-linear directed interactions, respectively, between the theta activities. Exploration in the novelty condition was associated with increased theta power in the generators with EC origin. We found a significant directed interaction from the Schaffer input over the EC-III input in CA1, and a bidirectional interaction between the inputs in the hippocampus originating in the EC, likely reflecting the connection between layers II and III. During novelty exploration, the influence of the EC-II over the EC-III generator increased, while the Schaffer influence decreased. These results associate the increase in hippocampal theta activity and synchrony during novelty exploration with an increase in the directed functional connectivity from EC-II to EC-III.
- Published
- 2021
28. Different pathway specific theta frameworks coexist in the hippocampus and are coordinated during exploratory and memory guided behaviors
- Author
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Pérez-Montoyo, Elena, López-Madrona, Víctor J., Herreras, Óscar, Mirasso, Claudio R., Canals Gamoneda, Santiago, Generalitat Valenciana, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), and European Commission
- Abstract
Trabajo presentado al 12th Federation of European Neuroscience Societies (FENS): Virtual Forum of NeuroScience, celebrado del 11 al 15 de julio de 2020., This work was supported in part by the Spanish Ministerio de Economía y Competitividad (and FEDER funds under the grant PGC2018-101055-B-I00 We acknowledge financial support from the Spanish State Research Agency, through the Severo Ochoa” Programme for Centres of Excellence in R&D ref SEV2017-0723 EPM was supported by a studentship from the Consellería de Educación Investigación Cultura y Deporte (ACIF/2016/110).
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- 2020
29. Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
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Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, European Commission, Ministerio de Economía y Empresa, Agencia Estatal de Investigación, European Regional Development Fund, Ministerio de Economía y Competitividad, López-Madrona, Víctor J., Pérez-Montoyo, Elena, Alvarez-Salvado, Efren, Moratal, David, Herreras, Oscar, Pereda, Ernesto, Mirasso, Claudio R., Canals, Santiago, Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, European Commission, Ministerio de Economía y Empresa, Agencia Estatal de Investigación, European Regional Development Fund, Ministerio de Economía y Competitividad, López-Madrona, Víctor J., Pérez-Montoyo, Elena, Alvarez-Salvado, Efren, Moratal, David, Herreras, Oscar, Pereda, Ernesto, Mirasso, Claudio R., and Canals, Santiago
- Abstract
[EN] Hippocampal firing is organized in theta sequences controlled by internal memory processes and by external sensory cues, but how these computations are coordinated is not fully understood. Although theta activity is commonly studied as a unique coherent oscillation, it is the result of complex interactions between different rhythm generators. Here, by separating hippocampal theta activity in three different current generators, we found epochs with variable theta frequency and phase coupling, suggesting flexible interactions between theta generators. We found that epochs of highly synchronized theta rhythmicity preferentially occurred during behavioral tasks requiring coordination between internal memory representations and incoming sensory information. In addition, we found that gamma oscillations were associated with specific theta generators and the strength of theta-gamma coupling predicted the synchronization between theta generators. We propose a mechanism for segregating or integrating hippocampal computations based on the flexible coordination of different theta frameworks to accommodate the cognitive needs.
- Published
- 2020
30. Different pathway specific theta frameworks coexist in the hippocampus and are coordinated during exploratory and memory guided behaviors
- Author
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Generalitat Valenciana, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Pérez-Montoyo, Elena, López-Madrona, Víctor J., Herreras, Óscar, Mirasso, Claudio R., Canals, Santiago, Generalitat Valenciana, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Pérez-Montoyo, Elena, López-Madrona, Víctor J., Herreras, Óscar, Mirasso, Claudio R., and Canals, Santiago
- Published
- 2020
31. Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
- Author
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Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Agencia Estatal de Investigación (España), Fundación la Caixa, López-Madrona, Víctor J., Pérez-Montoyo, Elena, Álvarez Salvado, Efrén, Moratal, David, Herreras, Óscar, Pereda, Ernesto, Mirasso, Claudio R., Canals, Santiago, Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Agencia Estatal de Investigación (España), Fundación la Caixa, López-Madrona, Víctor J., Pérez-Montoyo, Elena, Álvarez Salvado, Efrén, Moratal, David, Herreras, Óscar, Pereda, Ernesto, Mirasso, Claudio R., and Canals, Santiago
- Abstract
Hippocampal firing is organized in theta sequences controlled by internal memory processes and by external sensory cues, but how these computations are coordinated is not fully understood. Although theta activity is commonly studied as a unique coherent oscillation, it is the result of complex interactions between different rhythm generators. Here, by separating hippocampal theta activity in three different current generators, we found epochs with variable theta frequency and phase coupling, suggesting flexible interactions between theta generators. We found that epochs of highly synchronized theta rhythmicity preferentially occurred during behavioral tasks requiring coordination between internal memory representations and incoming sensory information. In addition, we found that gamma oscillations were associated with specific theta generators and the strength of theta-gamma coupling predicted the synchronization between theta generators. We propose a mechanism for segregating or integrating hippocampal computations based on the flexible coordination of different theta frameworks to accommodate the cognitive needs.
- Published
- 2020
32. Extracting seizure onset from surface EEG with independent component analysis: Insights from simultaneous scalp and intracerebral EEG
- Author
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Barborica, Andrei, primary, Mindruta, Ioana, additional, Sheybani, Laurent, additional, Spinelli, Laurent, additional, Oane, Irina, additional, Pistol, Constantin, additional, Donos, Cristian, additional, López-Madrona, Víctor J, additional, Vulliemoz, Serge, additional, and Bénar, Christian-George, additional
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- 2021
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33. Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
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López-Madrona, Víctor J, primary, Pérez-Montoyo, Elena, additional, Álvarez-Salvado, Efrén, additional, Moratal, David, additional, Herreras, Oscar, additional, Pereda, Ernesto, additional, Mirasso, Claudio R, additional, and Canals, Santiago, additional
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- 2020
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34. Author response: Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
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López-Madrona, Víctor J, primary, Pérez-Montoyo, Elena, additional, Álvarez-Salvado, Efrén, additional, Moratal, David, additional, Herreras, Oscar, additional, Pereda, Ernesto, additional, Mirasso, Claudio R, additional, and Canals, Santiago, additional
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- 2020
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35. Slow-wave activity in the S1HL cortex Is contributed by different layer-specific field potential sources during development
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Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Cajal Blue Brain, European Commission, Ortuño, Tania, López-Madrona, Víctor J., Makarova, Julia, Tapia-González, Silvia, Muñoz, Alberto, DeFelipe, Javier, Herreras, Óscar, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Cajal Blue Brain, European Commission, Ortuño, Tania, López-Madrona, Víctor J., Makarova, Julia, Tapia-González, Silvia, Muñoz, Alberto, DeFelipe, Javier, and Herreras, Óscar
- Abstract
Spontaneous correlated activity in cortical columns is critical for postnatal circuit refinement. We used spatial discrimination techniques to explore the late maturation of synaptic pathways through the laminar distribution of the field potential (FP) generators underlying spontaneous and evoked activities of the S1HL cortex in juvenile (P14-P16) and adult anesthetized rats. Juveniles exhibit an intermittent FP pattern resembling Up/Down states in adults, but with much reduced power and different laminar distribution. Whereas FPs in active periods are dominated by a layer VI generator in juveniles, in adults a developing multipart generator takes over, displaying current sinks in middle layers (III-V). The blockade of excitatory transmission in upper and middle layers of adults recovered the juvenile-like FP profiles. In addition to the layer VI generator, a gamma-specific generator in supragranular layers was the same in both age groups. While searching for dynamical coupling among generators in juveniles we found significant cross-correlation in ∼one-half of the tested pairs, whereas excessive coherence hindered their efficient separation in adults. Also, potentials evoked by tactile and electrical stimuli showed different short-latency dipoles between the two age groups, and the juveniles lacked the characteristic long latency UP state currents in middle layers. In addition, the mean firing rate of neurons was lower in juveniles. Thus, cortical FPs originate from different intra-columnar segments as they become active postnatally. We suggest that although some cortical segments are active early postnatally, a functional sensory-motor control relies on a delayed maturation and network integration of synaptic connections in middle layers.SIGNIFICANCE STATEMENT Early postnatal activity in the rodent cortex is mostly endogenous, whereas it becomes driven by peripheral input at later stages. The precise schedule for the maturation of synaptic pathways is largely unkn
- Published
- 2019
36. Inferring correlations associated to causal interactions in brain signals using autoregressive models
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Ministerio de Economía y Competitividad (España), European Commission, Agencia Estatal de Investigación (España), National Science Foundation (US), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundación la Caixa, López-Madrona, Víctor J., Matias, Fernanda S., Mirasso, Claudio R., Canals, Santiago, Pereda, Ernesto, Ministerio de Economía y Competitividad (España), European Commission, Agencia Estatal de Investigación (España), National Science Foundation (US), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundación la Caixa, López-Madrona, Víctor J., Matias, Fernanda S., Mirasso, Claudio R., Canals, Santiago, and Pereda, Ernesto
- Abstract
The specific connectivity of a neuronal network is reflected in the dynamics of the signals recorded on its nodes. The analysis of how the activity in one node predicts the behaviour of another gives the directionality in their relationship. However, each node is composed of many different elements which define the properties of the links. For instance, excitatory and inhibitory neuronal subtypes determine the functionality of the connection. Classic indexes such as the Granger causality (GC) quantifies these interactions, but they do not infer into the mechanism behind them. Here, we introduce an extension of the well-known GC that analyses the correlation associated to the specific influence that a transmitter node has over the receiver. This way, the G-causal link has a positive or negative effect if the predicted activity follows directly or inversely, respectively, the dynamics of the sender. The method is validated in a neuronal population model, testing the paradigm that excitatory and inhibitory neurons have a differential effect in the connectivity. Our approach correctly infers the positive or negative coupling produced by different types of neurons. Our results suggest that the proposed approach provides additional information on the characterization of G-causal connections, which is potentially relevant when it comes to understanding interactions in the brain circuits.
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- 2019
37. Encoding of memories: effective connectivity on the hippocampus and the role of inhibition in the information flow
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López-Madrona, Víctor J., Matías, Fernanda S., Pereda, Ernesto, Mirasso, Claudio, and Canals, Santiago
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Computational Neuroscience ,Neurons, networks, dynamical systems - Published
- 2017
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38. On the role of the entorhinal cortex in the effective connectivity of the hippocampal formation
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Ministerio de Economía y Competitividad (España), López-Madrona, Víctor J., Matias, Fernanda S., Pereda, Ernesto, Canals, Santiago, Mirasso, Claudio R., Ministerio de Economía y Competitividad (España), López-Madrona, Víctor J., Matias, Fernanda S., Pereda, Ernesto, Canals, Santiago, and Mirasso, Claudio R.
- Abstract
Inferring effective connectivity from neurophysiological data is a challenging task. In particular, only a finite (and usually small) number of sites are simultaneously recorded, while the response of one of these sites can be influenced by other sites that are not being recorded. In the hippocampal formation, for instance, the connections between areas CA1-CA3, the dentate gyrus (DG), and the entorhinal cortex (EC) are well established. However, little is known about the relations within the EC layers, which might strongly affect the resulting effective connectivity estimations. In this work, we build excitatory/inhibitory neuronal populations representing the four areas CA1, CA3, the DG, and the EC and fix their connectivities. We model the EC by three layers (LII, LIII, and LV) and assume any possible connection between them. Our results, based on Granger Causality (GC) and Partial Transfer Entropy (PTE) measurements, reveal that the estimation of effective connectivity in the hippocampus strongly depends on the connectivities between EC layers. Moreover, we find, for certain EC configurations, very different results when comparing GC and PTE measurements. We further demonstrate that causal links can be robustly inferred regardless of the excitatory or inhibitory nature of the connection, adding complexity to their interpretation. Overall, our work highlights the importance of a careful analysis of the connectivity methods to prevent unrealistic conclusions when only partial information about the experimental system is available, as usually happens in brain networks. Our results suggest that the combination of causality measures with neuronal modeling based on precise neuroanatomical tracing may provide a powerful framework to disambiguate causal interactions in the brain.
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- 2017
39. 26th Annual Computational Neuroscience Meeting (CNS*2017): Part 2
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Rubchinsky, Leonid L., primary, Ahn, Sungwoo, additional, Klijn, Wouter, additional, Cumming, Ben, additional, Yates, Stuart, additional, Karakasis, Vasileios, additional, Peyser, Alexander, additional, Woodman, Marmaduke, additional, Diaz-Pier, Sandra, additional, Deraeve, James, additional, Vassena, Eliana, additional, Alexander, William, additional, Beeman, David, additional, Kudela, Pawel, additional, Boatman-Reich, Dana, additional, Anderson, William S., additional, Luque, Niceto R., additional, Naveros, Francisco, additional, Carrillo, Richard R., additional, Ros, Eduardo, additional, Arleo, Angelo, additional, Huth, Jacob, additional, Ichinose, Koki, additional, Park, Jihoon, additional, Kawai, Yuji, additional, Suzuki, Junichi, additional, Mori, Hiroki, additional, Asada, Minoru, additional, Oprisan, Sorinel A., additional, Dave, Austin I., additional, Babaie, Tahereh, additional, Robinson, Peter, additional, Tabas, Alejandro, additional, Andermann, Martin, additional, Rupp, André, additional, Balaguer-Ballester, Emili, additional, Lindén, Henrik, additional, Christensen, Rasmus K., additional, Nakamura, Mari, additional, Barkat, Tania R., additional, Tosi, Zach, additional, Beggs, John, additional, Lonardoni, Davide, additional, Boi, Fabio, additional, Di Marco, Stefano, additional, Maccione, Alessandro, additional, Berdondini, Luca, additional, Jędrzejewska-Szmek, Joanna, additional, Dorman, Daniel B., additional, Blackwell, Kim T., additional, Bauermeister, Christoph, additional, Keren, Hanna, additional, Braun, Jochen, additional, Dornas, João V., additional, Mavritsaki, Eirini, additional, Aldrovandi, Silvio, additional, Bridger, Emma, additional, Lim, Sukbin, additional, Brunel, Nicolas, additional, Buchin, Anatoly, additional, Kerr, Clifford Charles, additional, Chizhov, Anton, additional, Huberfeld, Gilles, additional, Miles, Richard, additional, Gutkin, Boris, additional, Spencer, Martin J., additional, Meffin, Hamish, additional, Grayden, David B., additional, Burkitt, Anthony N., additional, Davey, Catherine E., additional, Tao, Liangyu, additional, Tiruvadi, Vineet, additional, Ali, Rehman, additional, Mayberg, Helen, additional, Butera, Robert, additional, Gunay, Cengiz, additional, Lamb, Damon, additional, Calabrese, Ronald L., additional, Doloc-Mihu, Anca, additional, López-Madrona, Víctor J., additional, Matias, Fernanda S., additional, Pereda, Ernesto, additional, Mirasso, Claudio R., additional, Canals, Santiago, additional, Geminiani, Alice, additional, Pedrocchi, Alessandra, additional, D’Angelo, Egidio, additional, Casellato, Claudia, additional, Chauhan, Ankur, additional, Soman, Karthik, additional, Srinivasa Chakravarthy, V., additional, Muddapu, Vignayanandam R., additional, Chuang, Chao-Chun, additional, Chen, Nan-yow, additional, Bayati, Mehdi, additional, Melchior, Jan, additional, Wiskott, Laurenz, additional, Azizi, Amir Hossein, additional, Diba, Kamran, additional, Cheng, Sen, additional, Smirnova, Elena Y., additional, Yakimova, Elena G., additional, Chizhov, Anton V., additional, Chen, Nan-Yow, additional, Shih, Chi-Tin, additional, Florescu, Dorian, additional, Coca, Daniel, additional, Courtiol, Julie, additional, Jirsa, Viktor K., additional, Covolan, Roberto J. M., additional, Teleńczuk, Bartosz, additional, Kempter, Richard, additional, Curio, Gabriel, additional, Destexhe, Alain, additional, Parker, Jessica, additional, Klishko, Alexander N., additional, Prilutsky, Boris I., additional, Cymbalyuk, Gennady, additional, Franke, Felix, additional, Hierlemann, Andreas, additional, da Silveira, Rava Azeredo, additional, Casali, Stefano, additional, Masoli, Stefano, additional, Rizza, Martina, additional, Rizza, Martina Francesca, additional, Sun, Yinming, additional, Wong, Willy, additional, Farzan, Faranak, additional, Blumberger, Daniel M., additional, Daskalakis, Zafiris J., additional, Popovych, Svitlana, additional, Viswanathan, Shivakumar, additional, Rosjat, Nils, additional, Grefkes, Christian, additional, Daun, Silvia, additional, Gentiletti, Damiano, additional, Suffczynski, Piotr, additional, Gnatkovski, Vadym, additional, De Curtis, Marco, additional, Lee, Hyeonsu, additional, Paik, Se-Bum, additional, Choi, Woochul, additional, Jang, Jaeson, additional, Park, Youngjin, additional, Song, Jun Ho, additional, Song, Min, additional, Pallarés, Vicente, additional, Gilson, Matthieu, additional, Kühn, Simone, additional, Insabato, Andrea, additional, Deco, Gustavo, additional, Glomb, Katharina, additional, Ponce-Alvarez, Adrián, additional, Ritter, Petra, additional, Campo, Adria Tauste, additional, Thiele, Alexander, additional, Deeba, Farah, additional, Robinson, P. A., additional, van Albada, Sacha J., additional, Rowley, Andrew, additional, Hopkins, Michael, additional, Schmidt, Maximilian, additional, Stokes, Alan B., additional, Lester, David R., additional, Furber, Steve, additional, Diesmann, Markus, additional, Barri, Alessandro, additional, Wiechert, Martin T., additional, DiGregorio, David A., additional, Dimitrov, Alexander G., additional, Vich, Catalina, additional, Berg, Rune W., additional, Guillamon, Antoni, additional, Ditlevsen, Susanne, additional, Cazé, Romain D., additional, Girard, Benoît, additional, Doncieux, Stéphane, additional, Doyon, Nicolas, additional, Boahen, Frank, additional, Desrosiers, Patrick, additional, Laurence, Edward, additional, Dubé, Louis J., additional, Eleonora, Russo, additional, Durstewitz, Daniel, additional, Schmidt, Dominik, additional, Mäki-Marttunen, Tuomo, additional, Krull, Florian, additional, Bettella, Francesco, additional, Metzner, Christoph, additional, Devor, Anna, additional, Djurovic, Srdjan, additional, Dale, Anders M., additional, Andreassen, Ole A., additional, Einevoll, Gaute T., additional, Næss, Solveig, additional, Ness, Torbjørn V., additional, Halnes, Geir, additional, Halgren, Eric, additional, Pettersen, Klas H., additional, Sætra, Marte J., additional, Hagen, Espen, additional, Schiffer, Alina, additional, Grzymisch, Axel, additional, Persike, Malte, additional, Ernst, Udo, additional, Harnack, Daniel, additional, Ernst, Udo A., additional, Tomen, Nergis, additional, Zucca, Stefano, additional, Pasquale, Valentina, additional, Pica, Giuseppe, additional, Molano-Mazón, Manuel, additional, Chiappalone, Michela, additional, Panzeri, Stefano, additional, Fellin, Tommaso, additional, Oie, Kelvin S., additional, Boothe, David L., additional, Crone, Joshua C., additional, Yu, Alfred B., additional, Felton, Melvin A., additional, Zulfiqar, Isma, additional, Moerel, Michelle, additional, De Weerd, Peter, additional, Formisano, Elia, additional, Oie, Kelvin, additional, Franaszczuk, Piotr, additional, Diggelmann, Roland, additional, Fiscella, Michele, additional, Guarino, Domenico, additional, Antolík, Jan, additional, Davison, Andrew P., additional, Frègnac, Yves, additional, Etienne, Benjamin Xavier, additional, Frohlich, Flavio, additional, Lefebvre, Jérémie, additional, Marcos, Encarni, additional, Mattia, Maurizio, additional, Genovesio, Aldo, additional, Fedorov, Leonid A., additional, Dijkstra, Tjeerd M.H., additional, Sting, Louisa, additional, Hock, Howard, additional, Giese, Martin A., additional, Buhry, Laure, additional, Langlet, Clément, additional, Giovannini, Francesco, additional, Verbist, Christophe, additional, Salvadé, Stefano, additional, Giugliano, Michele, additional, Henderson, James A., additional, Wernecke, Hendrik, additional, Sándor, Bulcsú, additional, Gros, Claudius, additional, Voges, Nicole, additional, Dabrovska, Paulina, additional, Riehle, Alexa, additional, Brochier, Thomas, additional, Grün, Sonja, additional, Gu, Yifan, additional, Gong, Pulin, additional, Dumont, Grégory, additional, Novikov, Nikita A., additional, Gutkin, Boris S., additional, Tewatia, Parul, additional, Eriksson, Olivia, additional, Kramer, Andrei, additional, Santos, Joao, additional, Jauhiainen, Alexandra, additional, Kotaleski, Jeanette H., additional, Belić, Jovana J., additional, Kumar, Arvind, additional, Kotaleski, Jeanette Hellgren, additional, Shimono, Masanori, additional, Hatano, Naomichi, additional, Ahmad, Subutai, additional, Cui, Yuwei, additional, Hawkins, Jeff, additional, Senk, Johanna, additional, Korvasová, Karolína, additional, Tetzlaff, Tom, additional, Helias, Moritz, additional, Kühn, Tobias, additional, Denker, Michael, additional, Mana, PierGianLuca, additional, Dahmen, David, additional, Schuecker, Jannis, additional, Goedeke, Sven, additional, Keup, Christian, additional, Heuer, Katja, additional, Bakker, Rembrandt, additional, Tiesinga, Paul, additional, Toro, Roberto, additional, Qin, Wei, additional, Hadjinicolaou, Alex, additional, Ibbotson, Michael R., additional, Kameneva, Tatiana, additional, Lytton, William W., additional, Mulugeta, Lealem, additional, Drach, Andrew, additional, Myers, Jerry G., additional, Horner, Marc, additional, Vadigepalli, Rajanikanth, additional, Morrison, Tina, additional, Walton, Marlei, additional, Steele, Martin, additional, Anthony Hunt, C., additional, Tam, Nicoladie, additional, Amaducci, Rodrigo, additional, Muñiz, Carlos, additional, Reyes-Sánchez, Manuel, additional, Rodríguez, Francisco B., additional, Varona, Pablo, additional, Cronin, Joseph T., additional, Hennig, Matthias H., additional, Iavarone, Elisabetta, additional, Yi, Jane, additional, Shi, Ying, additional, Zandt, Bas-Jan, additional, Van Geit, Werner, additional, Rössert, Christian, additional, Markram, Henry, additional, Hill, Sean, additional, O’Reilly, Christian, additional, Perin, Rodrigo, additional, Lu, Huanxiang, additional, Bryson, Alexander, additional, Hadrava, Michal, additional, Hlinka, Jaroslav, additional, Hosaka, Ryosuke, additional, Olenik, Mark, additional, Houghton, Conor, additional, Iannella, Nicolangelo, additional, Launey, Thomas, additional, Kotsakidis, Rebecca, additional, Soriano, Jaymar, additional, Kubo, Takatomi, additional, Inoue, Takao, additional, Kida, Hiroyuki, additional, Yamakawa, Toshitaka, additional, Suzuki, Michiyasu, additional, Ikeda, Kazushi, additional, Abbasi, Samira, additional, Hudson, Amber E., additional, Heck, Detlef H., additional, Jaeger, Dieter, additional, Lee, Joel, additional, Janušonis, Skirmantas, additional, Saggio, Maria Luisa, additional, Spiegler, Andreas, additional, Stacey, William C., additional, Bernard, Christophe, additional, Lillo, Davide, additional, Petkoski, Spase, additional, Drakesmith, Mark, additional, Jones, Derek K., additional, Zadeh, Ali Sadegh, additional, Kambhampati, Chandra, additional, Karbowski, Jan, additional, Kaya, Zeynep Gokcen, additional, Lakretz, Yair, additional, Treves, Alessandro, additional, Li, Lily W., additional, Lizier, Joseph, additional, Kerr, Cliff C., additional, Masquelier, Timothée, additional, Kheradpisheh, Saeed Reza, additional, Kim, Hojeong, additional, Kim, Chang Sub, additional, Marakshina, Julia A., additional, Vartanov, Alexander V., additional, Neklyudova, Anastasia A., additional, Kozlovskiy, Stanislav A., additional, Kiselnikov, Andrey A., additional, Taniguchi, Kanako, additional, Kitano, Katsunori, additional, Schmitt, Oliver, additional, Lessmann, Felix, additional, Schwanke, Sebastian, additional, Eipert, Peter, additional, Meinhardt, Jennifer, additional, Beier, Julia, additional, Kadir, Kanar, additional, Karnitzki, Adrian, additional, Sellner, Linda, additional, Klünker, Ann-Christin, additional, Kuch, Lena, additional, Ruß, Frauke, additional, Jenssen, Jörg, additional, Wree, Andreas, additional, Sanz-Leon, Paula, additional, Knock, Stuart A., additional, Chien, Shih-Cheng, additional, Maess, Burkhard, additional, Knösche, Thomas R., additional, Cohen, Charles C., additional, Popovic, Marko A., additional, Klooster, Jan, additional, Kole, Maarten H.P., additional, Roberts, Erik A., additional, Kopell, Nancy J., additional, Kepple, Daniel, additional, Giaffar, Hamza, additional, Rinberg, Dima, additional, Koulakov, Alex, additional, Forlim, Caroline Garcia, additional, Klock, Leonie, additional, Bächle, Johanna, additional, Stoll, Laura, additional, Giemsa, Patrick, additional, Fuchs, Marie, additional, Schoofs, Nikola, additional, Montag, Christiane, additional, Gallinat, Jürgen, additional, Lee, Ray X., additional, Stephens, Greg J., additional, Kuhn, Bernd, additional, Tauffer, Luiz, additional, Isope, Philippe, additional, Inoue, Katsuma, additional, Ohmura, Yoshiyuki, additional, Yonekura, Shogo, additional, Kuniyoshi, Yasuo, additional, Jang, Hyun Jae, additional, Kwag, Jeehyun, additional, de Kamps, Marc, additional, Lai, Yi Ming, additional, dos Santos, Filipa, additional, Lam, K. P., additional, Andras, Peter, additional, Imperatore, Julia, additional, Helms, Jessica, additional, Tompa, Tamas, additional, Lavin, Antonieta, additional, Inkpen, Felicity H., additional, Ashby, Michael C., additional, Lepora, Nathan F., additional, Shifman, Aaron R., additional, Lewis, John E., additional, Zhang, Zhong, additional, Feng, Yeqian, additional, Tetzlaff, Christian, additional, Kulvicius, Tomas, additional, Li, Yinyun, additional, Pena, Rodrigo F. O., additional, Bernardi, Davide, additional, Roque, Antonio C., additional, Lindner, Benjamin, additional, Vellmer, Sebastian, additional, Saudargiene, Ausra, additional, Maninen, Tiina, additional, Havela, Riikka, additional, Linne, Marja-Leena, additional, Powanwe, Arthur, additional, Longtin, Andre, additional, Garrido, Jesús A., additional, Graham, Joe W., additional, Dura-Bernal, Salvador, additional, Angulo, Sergio L., additional, Neymotin, Samuel A., additional, and Antic, Srdjan D., additional
- Published
- 2017
- Full Text
- View/download PDF
40. 26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3
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Newton, Adam J. H., primary, Seidenstein, Alexandra H., additional, McDougal, Robert A., additional, Pérez-Cervera, Alberto, additional, Huguet, Gemma, additional, M-Seara, Tere, additional, Haimerl, Caroline, additional, Angulo-Garcia, David, additional, Torcini, Alessandro, additional, Cossart, Rosa, additional, Malvache, Arnaud, additional, Skiker, Kaoutar, additional, Maouene, Mounir, additional, Ragognetti, Gianmarco, additional, Lorusso, Letizia, additional, Viggiano, Andrea, additional, Marcelli, Angelo, additional, Senatore, Rosa, additional, Parziale, Antonio, additional, Stramaglia, S., additional, Pellicoro, M., additional, Angelini, L., additional, Amico, E., additional, Aerts, H., additional, Cortés, J., additional, Laureys, S., additional, Marinazzo, D., additional, Bassez, I., additional, Faes, L., additional, Almgren, Hannes, additional, Razi, Adeel, additional, Van de Steen, Frederik, additional, Krebs, Ruth, additional, Aerts, Hannelore, additional, Kanari, Lida, additional, Dlotko, Pawel, additional, Scolamiero, Martina, additional, Levi, Ran, additional, Shillcock, Julian, additional, de Kock, Christiaan P.J., additional, Hess, Kathryn, additional, Markram, Henry, additional, Ly, Cheng, additional, Marsat, Gary, additional, Gillespie, Tom, additional, Sandström, Malin, additional, Abrams, Mathew, additional, Grethe, Jeffrey S., additional, Martone, Maryann, additional, De Gernier, Robin, additional, Solinas, Sergio, additional, Rössert, Christian, additional, Haelterman, Marc, additional, Massar, Serge, additional, Pasquale, Valentina, additional, Pastore, Vito Paolo, additional, Martinoia, Sergio, additional, Massobrio, Paolo, additional, Capone, Cristiano, additional, Tort-Colet, Núria, additional, Sanchez-Vives, Maria V., additional, Mattia, Maurizio, additional, Almasi, Ali, additional, Cloherty, Shaun L., additional, Grayden, David B., additional, Wong, Yan T., additional, Ibbotson, Michael R., additional, Meffin, Hamish, additional, Prince, Luke Y., additional, Tsaneva-Atanasova, Krasimira, additional, Mellor, Jack R., additional, Mazzoni, Alberto, additional, Rosa, Manuela, additional, Carpaneto, Jacopo, additional, Romito, Luigi M., additional, Priori, Alberto, additional, Micera, Silvestro, additional, Migliore, Rosanna, additional, Lupascu, Carmen Alina, additional, Franchina, Francesco, additional, Bologna, Luca Leonardo, additional, Romani, Armando, additional, Saray, Sára, additional, Van Geit, Werner, additional, Káli, Szabolcs, additional, Thomson, Alex, additional, Mercer, Audrey, additional, Lange, Sigrun, additional, Falck, Joanne, additional, Muller, Eilif, additional, Schürmann, Felix, additional, Todorov, Dmitrii, additional, Capps, Robert, additional, Barnett, William, additional, Molkov, Yaroslav, additional, Devalle, Federico, additional, Pazó, Diego, additional, Montbrió, Ernest, additional, Mochol, Gabriela, additional, Azab, Habiba, additional, Hayden, Benjamin Y., additional, Moreno-Bote, Rubén, additional, Balasubramani, Pragathi Priyadharsini, additional, Chakravarthy, Srinivasa V., additional, Muddapu, Vignayanandam R., additional, Gheorghiu, Medorian D., additional, Mimica, Bartul, additional, Withlock, Jonathan, additional, Mureșan, Raul C., additional, Zick, Jennifer L., additional, Schultz, Kelsey, additional, Blackman, Rachael K., additional, Chafee, Matthew V., additional, Netoff, Theoden I., additional, Roberts, Nicholas, additional, Nagaraj, Vivek, additional, Lamperski, Andrew, additional, Grado, Logan L., additional, Johnson, Matthew D., additional, Darrow, David P., additional, Lonardoni, Davide, additional, Amin, Hayder, additional, Di Marco, Stefano, additional, Maccione, Alessandro, additional, Berdondini, Luca, additional, Nieus, Thierry, additional, Stimberg, Marcel, additional, Goodman, Dan F. M., additional, Nowotny, Thomas, additional, Koren, Veronika, additional, Dragoi, Valentin, additional, Obermayer, Klaus, additional, Castro, Samy, additional, Fernandez, Mariano, additional, El-Deredy, Wael, additional, Xu, Kesheng, additional, Maidana, Jean Paul, additional, Orio, Patricio, additional, Chen, Weiliang, additional, Hepburn, Iain, additional, Casalegno, Francesco, additional, Devresse, Adrien, additional, Ovcharenko, Aleksandr, additional, Pereira, Fernando, additional, Delalondre, Fabien, additional, De Schutter, Erik, additional, Bratby, Peter, additional, Gallimore, Andrew R., additional, Klingbeil, Guido, additional, Zamora, Criseida, additional, Zang, Yunliang, additional, Crotty, Patrick, additional, Palmerduca, Eric, additional, Antonietti, Alberto, additional, Casellato, Claudia, additional, Erö, Csaba, additional, D’Angelo, Egidio, additional, Gewaltig, Marc-Oliver, additional, Pedrocchi, Alessandra, additional, Bytschok, Ilja, additional, Dold, Dominik, additional, Schemmel, Johannes, additional, Meier, Karlheinz, additional, Petrovici, Mihai A., additional, Shen, Hui-An, additional, Surace, Simone Carlo, additional, Pfister, Jean-Pascal, additional, Lefebvre, Baptiste, additional, Marre, Olivier, additional, Yger, Pierre, additional, Papoutsi, Athanasia, additional, Park, Jiyoung, additional, Ash, Ryan, additional, Smirnakis, Stelios, additional, Poirazi, Panayiota, additional, Felix, Richard A., additional, Dimitrov, Alexander G., additional, Portfors, Christine, additional, Daun, Silvia, additional, Toth, Tibor I., additional, Jędrzejewska-Szmek, Joanna, additional, Kabbani, Nadine, additional, Blackwel, Kim T., additional, Moezzi, Bahar, additional, Schaworonkow, Natalie, additional, Plogmacher, Lukas, additional, Goldsworthy, Mitchell R., additional, Hordacre, Brenton, additional, McDonnell, Mark D., additional, Iannella, Nicolangelo, additional, Ridding, Michael C., additional, Triesch, Jochen, additional, Maex, Reinoud, additional, Safaryan, Karen, additional, Steuber, Volker, additional, Tang, Rongxiang, additional, Tang, Yi-Yuan, additional, Verveyko, Darya V., additional, Brazhe, Alexey R., additional, Verisokin, Andrey Yu, additional, Postnov, Dmitry E., additional, Günay, Cengiz, additional, Panuccio, Gabriella, additional, Giugliano, Michele, additional, Prinz, Astrid A., additional, Varona, Pablo, additional, Rabinovich, Mikhail I., additional, Denham, Jack, additional, Ranner, Thomas, additional, Cohen, Netta, additional, Reva, Maria, additional, Rebola, Nelson, additional, Kirizs, Tekla, additional, Nusser, Zoltan, additional, DiGregorio, David, additional, Mavritsaki, Eirini, additional, Rentzelas, Panos, additional, Ukani, Nikul H., additional, Tomkins, Adam, additional, Yeh, Chung-Heng, additional, Bruning, Wesley, additional, Fenichel, Allison L., additional, Zhou, Yiyin, additional, Huang, Yu-Chi, additional, Florescu, Dorian, additional, Ortiz, Carlos Luna, additional, Richmond, Paul, additional, Lo, Chung-Chuan, additional, Coca, Daniel, additional, Chiang, Ann-Shyn, additional, Lazar, Aurel A., additional, Creaser, Jennifer L., additional, Lin, Congping, additional, Ashwin, Peter, additional, Brown, Jonathan T., additional, Ridler, Thomas, additional, Levenstein, Daniel, additional, Watson, Brendon O., additional, Buzsáki, György, additional, Rinzel, John, additional, Curtu, Rodica, additional, Nguyen, Anh, additional, Assadzadeh, Sahand, additional, Robinson, Peter A., additional, Sanz-Leon, Paula, additional, Forlim, Caroline G., additional, de Almeida, Lírio O. B., additional, Pinto, Reynaldo D., additional, Rodríguez, Francisco B., additional, Lareo, Ángel, additional, Forlim, Caroline Garcia, additional, Montero, Aaron, additional, Mosqueiro, Thiago, additional, Huerta, Ramon, additional, Rodriguez, Francisco B., additional, Changoluisa, Vinicio, additional, Cordeiro, Vinícius L., additional, Ceballos, César C., additional, Kamiji, Nilton L., additional, Roque, Antonio C., additional, Lytton, William W., additional, Knox, Andrew, additional, Rosenthal, Joshua J. C., additional, Popovych, Svitlana, additional, Liu, Liqing, additional, Wang, Bin A., additional, Tóth, Tibor I., additional, Grefkes, Christian, additional, Fink, Gereon R., additional, Rosjat, Nils, additional, Perez-Trujillo, Abraham, additional, Espinal, Andres, additional, Sotelo-Figueroa, Marco A., additional, Cruz-Aceves, Ivan, additional, Rostro-Gonzalez, Horacio, additional, Zapotocky, Martin, additional, Hoskovcová, Martina, additional, Kopecká, Jana, additional, Ulmanová, Olga, additional, Růžička, Evžen, additional, Gärtner, Matthias, additional, Duvarci, Sevil, additional, Roeper, Jochen, additional, Schneider, Gaby, additional, Albert, Stefan, additional, Schmack, Katharina, additional, Remme, Michiel, additional, Schreiber, Susanne, additional, Migliore, Michele, additional, Lupascu, Carmen A., additional, Bologna, Luca L., additional, Antonel, Stefano M., additional, Courcol, Jean-Denis, additional, Çelikok, Sami Utku, additional, Navarro-López, Eva M., additional, Şengör, Neslihan Serap, additional, Elibol, Rahmi, additional, Sengor, Neslihan Serap, additional, Özdemir, Mustafa Yasir, additional, Li, Tianyi, additional, Arleo, Angelo, additional, Sheynikhovich, Denis, additional, Nakamura, Akihiro, additional, Shimono, Masanori, additional, Song, Youngjo, additional, Park, Sol, additional, Choi, Ilhwan, additional, Jeong, Jaeseung, additional, Shin, Hee-sup, additional, Sadeh, Sadra, additional, Gleeson, Padraig, additional, Angus Silver, R., additional, Chatzikalymniou, Alexandra Pierri, additional, Skinner, Frances K., additional, Sanchez-Rodriguez, Lazaro M., additional, Sotero, Roberto C., additional, Hertäg, Loreen, additional, Mackwood, Owen, additional, Sprekeler, Henning, additional, Puhlmann, Steffen, additional, Weber, Simon N., additional, Higgins, David, additional, Naumann, Laura B., additional, Iyer, Ramakrisnan, additional, Mihalas, Stefan, additional, Ticcinelli, Valentina, additional, Stankovski, Tomislav, additional, McClintock, Peter V. E., additional, Stefanovska, Aneta, additional, Janjić, Predrag, additional, Solev, Dimitar, additional, Seifert, Gerald, additional, Kocarev, Ljupčo, additional, Steinhäuser, Christian, additional, Salmasi, Mehrdad, additional, Glasauer, Stefan, additional, Stemmler, Martin, additional, Zhang, Danke, additional, Zhang, Chi, additional, Stepanyants, Armen, additional, Goncharenko, Julia, additional, Kros, Lieke, additional, Davey, Neil, additional, de Zeeuw, Chris, additional, Hoebeek, Freek, additional, Sinha, Ankur, additional, Adams, Roderick, additional, Schmuker, Michael, additional, Psarrou, Maria, additional, Schilstra, Maria, additional, Torben-Nielsen, Benjamin, additional, Metzner, Christoph, additional, Schweikard, Achim, additional, Mäki-Marttunen, Tuomo, additional, Zurowski, Bartosz, additional, Marinazzo, Daniele, additional, Faes, Luca, additional, Stramaglia, Sebastiano, additional, Jordan, Henry O. C., additional, Stringer, Simon M., additional, Gajewska-Dendek, Elżbieta, additional, Suffczyński, Piotr, additional, Tam, Nicoladie, additional, Zouridakis, George, additional, Pollonini, Luca, additional, Asl, Mojtaba Madadi, additional, Valizadeh, Alireza, additional, Tass, Peter A., additional, Nold, Andreas, additional, Fan, Wei, additional, Konrad, Sara, additional, Endle, Heiko, additional, Vogt, Johannes, additional, Tchumatchenko, Tatjana, additional, Herpich, Juliane, additional, Tetzlaff, Christian, additional, Luboeinski, Jannik, additional, Nachstedt, Timo, additional, Ciba, Manuel, additional, Bahmer, Andreas, additional, Thielemann, Christiane, additional, Kuebler, Eric S., additional, Tauskela, Joseph S., additional, Thivierge, Jean-Philippe, additional, Bakker, Rembrandt, additional, García-Amado, María, additional, Evangelio, Marian, additional, Clascá, Francisco, additional, Tiesinga, Paul, additional, Buckley, Christopher L., additional, Toyoizumi, Taro, additional, Dubreuil, Alexis M., additional, Monasson, Rémi, additional, Treves, Alessandro, additional, Spalla, Davide, additional, Rosay, Sophie, additional, Kleberg, Florence I., additional, Wong, Willy, additional, de Oliveira Floriano, Bruno, additional, Matsuo, Toshihiko, additional, Uchida, Tetsuya, additional, Dibenedetto, Domenica, additional, Uludağ, Kâmil, additional, Goodarzinick, Abdorreza, additional, Schmidt, Maximilian, additional, Hilgetag, Claus C., additional, Diesmann, Markus, additional, van Albada, Sacha J., additional, Fauth, Michael, additional, van Rossum, Mark, additional, Reyes-Sánchez, Manuel, additional, Amaducci, Rodrigo, additional, Muñiz, Carlos, additional, Elices, Irene, additional, Arroyo, David, additional, Levi, Rafael, additional, Cohen, Ben, additional, Chow, Carson, additional, Vattikuti, Shashaank, additional, Bertolotti, Elena, additional, Burioni, Raffaella, additional, di Volo, Matteo, additional, Vezzani, Alessandro, additional, Menzat, Bayar, additional, Vogels, Tim P., additional, Wagatsuma, Nobuhiko, additional, Saha, Susmita, additional, Kapoor, Reena, additional, Kerr, Robert, additional, Wagner, John, additional, del Molino, Luis C. Garcia, additional, Yang, Guangyu Robert, additional, Mejias, Jorge F., additional, Wang, Xiao-Jing, additional, Song, Hanbing, additional, Goodliffe, Joseph, additional, Luebke, Jennifer, additional, Weaver, Christina M., additional, Thomas, John, additional, Sinha, Nishant, additional, Shaju, Nikhita, additional, Maszczyk, Tomasz, additional, Jin, Jing, additional, Cash, Sydney S., additional, Dauwels, Justin, additional, Brandon Westover, M., additional, Karimian, Maryam, additional, Moerel, Michelle, additional, De Weerd, Peter, additional, Burwick, Thomas, additional, Westra, Ronald L., additional, Abeysuriya, Romesh, additional, Hadida, Jonathan, additional, Sotiropoulos, Stamatios, additional, Jbabdi, Saad, additional, Woolrich, Mark, additional, Bensmail, Chama, additional, Wrobel, Borys, additional, Zhou, Xiaolong, additional, Ji, Zilong, additional, Liu, Xiao, additional, Xia, Yan, additional, Wu, Si, additional, Wang, Xiao, additional, Zhang, Mingsha, additional, Ofer, Netanel, additional, Shefi, Orit, additional, Yaari, Gur, additional, Carnevale, Ted, additional, Majumdar, Amit, additional, Sivagnanam, Subhashini, additional, Yoshimoto, Kenneth, additional, Smirnova, Elena Y., additional, Amakhin, Dmitry V., additional, Malkin, Sergey L., additional, Zaitsev, Aleksey V., additional, Chizhov, Anton V., additional, Zaleshina, Margarita, additional, Zaleshin, Alexander, additional, Barranca, Victor J., additional, Zhu, George, additional, Skilling, Quinton M., additional, Maruyama, Daniel, additional, Ognjanovski, Nicolette, additional, Aton, Sara J., additional, Zochowski, Michal, additional, Wu, Jiaxing, additional, Aton, Sara, additional, Rich, Scott, additional, Booth, Victoria, additional, Budak, Maral, additional, Dura-Bernal, Salvador, additional, Neymotin, Samuel A., additional, Suter, Benjamin A., additional, Shepherd, Gordon M. G., additional, Felton, Melvin A., additional, Yu, Alfred B., additional, Boothe, David L., additional, Oie, Kelvin S., additional, Franaszczuk, Piotr J., additional, Shuvaev, Sergey A., additional, Başerdem, Batuhan, additional, Zador, Anthony, additional, Koulakov, Alexei A., additional, López-Madrona, Víctor J., additional, Pereda, Ernesto, additional, Mirasso, Claudio R., additional, Canals, Santiago, additional, Masoli, Stefano, additional, Rongala, Udaya B., additional, Spanne, Anton, additional, Jorntell, Henrik, additional, Oddo, Calogero M., additional, Vartanov, Alexander V., additional, Neklyudova, Anastasia K., additional, Kozlovskiy, Stanislav A., additional, Kiselnikov, Andrey A., additional, Marakshina, Julia A., additional, Teleńczuk, Maria, additional, Teleńczuk, Bartosz, additional, Destexhe, Alain, additional, Kuokkanen, Paula T., additional, Kraemer, Anna, additional, McColgan, Thomas, additional, Carr, Catherine E., additional, and Kempter, Richard, additional
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- 2017
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- View/download PDF
41. On the role of the entorhinal cortex in the effective connectivity of the hippocampal formation
- Author
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López-Madrona, Víctor J., primary, Matias, Fernanda S., additional, Pereda, Ernesto, additional, Canals, Santiago, additional, and Mirasso, Claudio R., additional
- Published
- 2017
- Full Text
- View/download PDF
42. Site-dependent shaping of field potential waveforms.
- Author
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Herreras O, Torres D, Martín-Vázquez G, Hernández-Recio S, López-Madrona VJ, Benito N, Makarov VA, and Makarova J
- Subjects
- Hippocampus, Neurons physiology, Attention
- Abstract
The activity of neuron populations gives rise to field potentials (FPs) that extend beyond the sources. Their mixing in the volume dilutes the original temporal motifs in a site-dependent manner, a fact that has received little attention. And yet, it potentially rids of physiological significance the time-frequency parameters of individual waves (amplitude, phase, duration). This is most likely to happen when a single source or a local origin is erroneously assumed. Recent studies using spatial treatment of these signals and anatomically realistic modeling of neuron aggregates provide convincing evidence for the multisource origin and site-dependent blend of FPs. Thus, FPs generated in primary structures like the neocortex and hippocampus reach far and cross-contaminate each other but also, they add and even impose their temporal traits on distant regions. Furthermore, both structures house neurons that act as spatially distinct (but overlapped) FP sources whose activation is state, region, and time dependent, making the composition of so-called local FPs highly volatile and strongly site dependent. Since the spatial reach cannot be predicted without source geometry, it is important to assess whether waveforms and temporal motifs arise from a single source; otherwise, those from each of the co-active sources should be sought., (© The Author(s) 2022. Published by Oxford University Press.)
- Published
- 2023
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- View/download PDF
43. On the role of the entorhinal cortex in the effective connectivity of the hippocampal formation.
- Author
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López-Madrona VJ, Matias FS, Pereda E, Canals S, and Mirasso CR
- Subjects
- Animals, Interneurons physiology, Models, Neurological, Rats, Time Factors, Entorhinal Cortex physiology, Hippocampus physiology, Nerve Net physiology
- Abstract
Inferring effective connectivity from neurophysiological data is a challenging task. In particular, only a finite (and usually small) number of sites are simultaneously recorded, while the response of one of these sites can be influenced by other sites that are not being recorded. In the hippocampal formation, for instance, the connections between areas CA1-CA3, the dentate gyrus (DG), and the entorhinal cortex (EC) are well established. However, little is known about the relations within the EC layers, which might strongly affect the resulting effective connectivity estimations. In this work, we build excitatory/inhibitory neuronal populations representing the four areas CA1, CA3, the DG, and the EC and fix their connectivities. We model the EC by three layers (LII, LIII, and LV) and assume any possible connection between them. Our results, based on Granger Causality (GC) and Partial Transfer Entropy (PTE) measurements, reveal that the estimation of effective connectivity in the hippocampus strongly depends on the connectivities between EC layers. Moreover, we find, for certain EC configurations, very different results when comparing GC and PTE measurements. We further demonstrate that causal links can be robustly inferred regardless of the excitatory or inhibitory nature of the connection, adding complexity to their interpretation. Overall, our work highlights the importance of a careful analysis of the connectivity methods to prevent unrealistic conclusions when only partial information about the experimental system is available, as usually happens in brain networks. Our results suggest that the combination of causality measures with neuronal modeling based on precise neuroanatomical tracing may provide a powerful framework to disambiguate causal interactions in the brain.
- Published
- 2017
- Full Text
- View/download PDF
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