1. Association of Specific Subtypes ofBorrelia burgdorferiwith Hematogenous Dissemination in Early Lyme Disease
- Author
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Gary P. Wormser, L F Cavaliere, Donna McKenna, Ira Schwartz, Dionysios Liveris, Diane Holmgren, John Nowakowski, and Robert B. Nadelman
- Subjects
Adult ,Biopsy ,Spirochaetaceae ,Polymerase Chain Reaction ,Lyme disease ,Borrelia burgdorferi Group ,parasitic diseases ,Genotype ,medicine ,Humans ,Immunology and Allergy ,Borrelia burgdorferi ,Phylogeny ,Skin ,Lyme Disease ,biology ,Genetic Variation ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease ,Virology ,Infectious Diseases ,Immunology ,Erythema chronicum migrans ,Erythema Chronicum Migrans ,Lyme disease microbiology ,Erythema migrans ,Restriction fragment length polymorphism ,medicine.symptom ,Polymorphism, Restriction Fragment Length - Abstract
To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classified into 3 groups by a polymerase chain reaction amplification and restriction fragment length polymorphism (RFLP) method. A highly significant association between infecting RFLP type in skin and the presence of spirochetemia was found (P
- Published
- 1999